+1 |BT| (S1 (S (NP (NP (NN Suppression)) (PP (IN of) (NP (NP (NN rat) (NN thromboxane) (NN synthase) (NN gene)) (NN transcription))) (PP (IN by) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN in) (NP (NNS macrophages))))) (PP (IN via) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (NP (NN Deletion) (NN analysis)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN element)) (ADJP (JJ responsible) (PP (IN for) (NP (DT the) (NN PPARgamma) (NN effect))))) (VP (VBZ is) (ADJP (JJ located) (PP (IN in) (NP (NP (DT a) (NN region)) (VP (VBG containing) (NP (NP (DT the) (JJ nuclear) (NN factor) (NN E2) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN _PROT2_) (NN site)) (PRN (-LRB- -LRB-) (NP (NN -98/-88)) (-RRB- -RRB-))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN indicated) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (JJ major) (NN promoter)) (PP (IN of) (NP (DT the) (NN TXS) (NN gene))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ electrophoretic) (NN mobility) (NN shift) (NN assay)) (VP (VBG using) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN site)) (CC and) (NP (NP (JJ nuclear) (NNS extracts)) (PP (IN from) (NP (NNS macrophages)))))))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ specific) (JJ protein-DNA) (NN complex) (NN formation)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (JJ specific) (NN antibody)) (PP (IN against) (NP (DT the) (NN transcription) (NN factor) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ electrophoretic) (NN mobility) (NN shift) (NN assay)) (VP (VBG using) (NP (NP (DT the) (NN _PROT1_) (NN site)) (CC and) (NP (NP (JJ nuclear) (NNS extracts)) (PP (IN from) (NP (NNS macrophages)))))))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ specific) (JJ protein-DNA) (NN complex) (NN formation)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (JJ specific) (NN antibody)) (PP (IN against) (NP (DT the) (NN transcription) (NN factor) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ electrophoretic) (NN mobility) (NN shift) (NN assay)) (VP (VBG using) (NP (NP (DT the) (NN _PROT1_) (NN site)) (CC and) (NP (NP (JJ nuclear) (NNS extracts)) (PP (IN from) (NP (NNS macrophages)))))))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ specific) (JJ protein-DNA) (NN complex) (NN formation)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (JJ specific) (NN antibody)) (PP (IN against) (NP (DT the) (NN transcription) (NN factor) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ electrophoretic) (NN mobility) (NN shift) (NN assay)) (VP (VBG using) (NP (NP (DT the) (NN _PROT1_) (NN site)) (CC and) (NP (NP (JJ nuclear) (NNS extracts)) (PP (IN from) (NP (NNS macrophages)))))))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ specific) (JJ protein-DNA) (NN complex) (NN formation)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (JJ specific) (NN antibody)) (PP (IN against) (NP (DT the) (NN transcription) (NN factor) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ electrophoretic) (NN mobility) (NN shift) (NN assay)) (VP (VBG using) (NP (NP (DT the) (NN _PROT1_) (NN site)) (CC and) (NP (NP (JJ nuclear) (NNS extracts)) (PP (IN from) (NP (NNS macrophages)))))))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ specific) (JJ protein-DNA) (NN complex) (NN formation)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (JJ specific) (NN antibody)) (PP (IN against) (NP (DT the) (NN transcription) (NN factor) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ electrophoretic) (NN mobility) (NN shift) (NN assay)) (VP (VBG using) (NP (NP (DT the) (NN _PROT_) (NN site)) (CC and) (NP (NP (JJ nuclear) (NNS extracts)) (PP (IN from) (NP (NNS macrophages)))))))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ specific) (JJ protein-DNA) (NN complex) (NN formation)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (JJ specific) (NN antibody)) (PP (IN against) (NP (DT the) (NN transcription) (NN factor) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (NN PPARgamma)) (CC and) (NP (NN _PROT1_))))) (VP (VBD was) (VP (VBN confirmed) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (JJ pull-down) (NN assay))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBD cloned)) (CC and) (VP (VBD characterized) (NP (NP (DT a) (NN mouse) (NN orthologue)) (PP (IN of) (NP (JJ human) (NN _PROT1_) (NN protein)))) (PP (IN as) (NP (DT an) (JJ atypical) (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (VBN named) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBD cloned)) (CC and) (VP (VBD characterized) (NP (NP (DT a) (NN mouse) (NN orthologue)) (PP (IN of) (NP (JJ human) (NN _PROT1_) (NN protein)))) (PP (IN as) (NP (DT an) (JJ atypical) (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (VBN named) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBD cloned)) (CC and) (VP (VBD characterized) (NP (NP (DT a) (NN mouse) (NN orthologue)) (PP (IN of) (NP (JJ human) (NN _PROT_) (NN protein)))) (PP (IN as) (NP (DT an) (JJ atypical) (NN _PROT1_))) (PRN (-LRB- -LRB-) (NP (VBN named) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Subcellular) (NN fractionation)) (CC and) (NP (JJ antibody-uptake) (NNS experiments))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_) (CD _PROT1_)) (VP (VP (VBZ is) (ADVP (RB indeed)) (NP (DT a) (JJ type-I) (NN membrane) (NN protein))) (, ,) (CC but) (, ,) (PP (IN unlike) (NP (JJ other) (NN _PROT2_) (NNS isoforms))) (, ,) (VP (VBZ lacks) (NP (DT an) (JJ N-terminal) (JJ extracellular) (NN domain))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Direct) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NN _PROT1_) (CD _PROT1_)))) (CC and) (NP (NP (DT the) (NN Src) (NN homology) (CD 3) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))) (VP (VBZ activates) (NP (NP (NN _PROT_) (NN _PROT_)) (PP (IN in) (NP (NN C2C12) (NNS cells))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Direct) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NN _PROT1_) (CD _PROT1_)))) (CC and) (NP (NP (DT the) (NN Src) (NN homology) (CD 3) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))) (VP (VBZ activates) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (IN in) (NP (NN C2C12) (NNS cells))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Direct) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (DT the) (NN Src) (NN homology) (CD 3) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))))) (VP (VBZ activates) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (IN in) (NP (NN C2C12) (NNS cells))))))) |ET|
+1 |BT| (S1 (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN transmembrane) (NN _PROT1_) (CD _PROT1_)) (, ,) (PP (IN by) (S (VP (VBG providing) (NP (NP (NN docking) (NNS sites)) (PP (IN for) (NP (NP (DT the) (NN Src) (NN homology) (CD 3) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))))) (, ,) (VP (VBZ activates) (NP (NN PI) (NN 3-kinase)) (PP (IN by) (S (VP (VBG mediating) (NP (NP (PRP$ its) (NN recruitment)) (PP (TO to) (NP (DT the) (NN membrane))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Modification)) (PP (IN of) (NP (ADJP (FW de) (FW novo)) (NN DNA) (NN methyltransferase) (NN 3a) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-))) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ modulates) (NP (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NP (NN histone) (NNS deacetylases)) (PRN (-LRB- -LRB-) (NP (NNS HDACs)) (-RRB- -RRB-))))) (CC and) (NP (PRP$ its) (NN capacity) (S (VP (TO to) (VP (VB repress) (NP (NN transcription)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT2_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT2_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT2_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (JJ multiple) (NNS components)) (PP (IN of) (NP (DT the) (NN sumoylation) (NN machinery)))) (, ,) (RB namely) (NP (NP (DT the) (NN E2) (NN sumo) (NN conjugating) (NN enzyme) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN E3) (NN sumo) (NNS ligases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG conjugating) (NP (NP (DT the) (NP (JJ small) (JJ ubiquitin-like) (NN modifier)) (NN polypeptide)) (, ,) (NP (NN _PROT2_)) (, ,)) (PP (TO to) (NP (PRP$ its) (NN target) (NNS proteins)))))))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN modified) (PP (IN by) (NP (NN _PROT2_))) (ADVP (ADVP (FW in) (FW vivo)) (CC and) (ADVP (FW in) (FW vitro)))))) (CC and) (S (NP (NP (DT the) (NN region)) (PP (IN of) (NP (NN _PROT_))) (ADJP (JJ responsible) (PP (IN for) (NP (NN interaction))))) (VP (VBZ maps) (PP (TO to) (NP (DT the) (JJ N-terminal) (JJ regulatory) (NN domain))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN modified) (PP (IN by) (NP (NN _PROT_))) (ADVP (ADVP (FW in) (FW vivo)) (CC and) (ADVP (FW in) (FW vitro)))))) (CC and) (S (NP (NP (DT the) (NN region)) (PP (IN of) (NP (NN _PROT2_))) (ADJP (JJ responsible) (PP (IN for) (NP (NN interaction))))) (VP (VBZ maps) (PP (TO to) (NP (DT the) (JJ N-terminal) (JJ regulatory) (NN domain))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN modified) (PP (IN by) (NP (NN _PROT1_))) (ADVP (ADVP (FW in) (FW vivo)) (CC and) (ADVP (FW in) (FW vitro)))))) (CC and) (S (NP (NP (DT the) (NN region)) (PP (IN of) (NP (NN _PROT2_))) (ADJP (JJ responsible) (PP (IN for) (NP (NN interaction))))) (VP (VBZ maps) (PP (TO to) (NP (DT the) (JJ N-terminal) (JJ regulatory) (NN domain))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Functionally)) (, ,) (NP (NP (NN sumoylation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ disrupts) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (PP (IN with) (NP (NP (NN histone) (NNS deacetylases)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT another) (NN interaction) (NN partner)) (, ,) (NP (NN _PROT_)))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Functionally)) (, ,) (NP (NP (NN sumoylation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ disrupts) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (PP (IN with) (NP (NP (NN histone) (NNS deacetylases)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT another) (NN interaction) (NN partner)) (, ,) (NP (NN _PROT2_)))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Functionally)) (, ,) (NP (NP (NN sumoylation)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ disrupts) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (PP (IN with) (NP (NP (NN histone) (NNS deacetylases)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT another) (NN interaction) (NN partner)) (, ,) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NN Syk)) (, ,) (CC and) (NP (NN phospholipase) (NN C-gamma))))) (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (PP (IN upon) (NP (NN B) (NN cell) (NN activation))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (VBN tyrosyl-phosphorylated) (NN _PROT1_)) (VP (MD may) (VP (VB be) (NP (DT a) (NN substrate)) (SBAR (IN for) (S (NP (NN _PROT2_)) (VP (VBZ regulates) (NP (NP (NN tyrosyl) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (VBN tyrosyl-phosphorylated) (NN _PROT1_)) (VP (MD may) (VP (VB be) (NP (DT a) (NN substrate)) (SBAR (IN for) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NP (NN tyrosyl) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (VBN tyrosyl-phosphorylated) (NN _PROT_)) (VP (MD may) (VP (VB be) (NP (DT a) (NN substrate)) (SBAR (IN for) (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NP (NN tyrosyl) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBD was) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ NH2-terminal) (NN Src) (NN homology) (CD 2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBD was) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ NH2-terminal) (NN Src) (NN homology) (CD 2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBD was) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ NH2-terminal) (NN Src) (NN homology) (CD 2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Complexes)) (PP (IN of) (NP (DT either) (NN _PROT1_AND_PROT2_)))) (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (VP (MD could) (VP (VB be) (VP (VBN isolated) (PP (IN from) (NP (NP (NN B) (NNS cells)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NP (NN BCR)) (NN engagement)) (CC or) (NP (NP (DT a) (NN mixture)) (PP (IN of) (NP (NP (NN hydrogen) (NN peroxidase)) (CC and) (NP (NN sodium) (NN orthovanadate)))))))))) (, ,) (ADVP (RB respectively))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Transient) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (DT a) (JJ null) (NN mutant)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN PTP-1CM)) (-RRB- -RRB-))))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NN tyrosyl) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN PTP-1CM))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Transient) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (DT a) (JJ null) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN PTP-1CM)) (-RRB- -RRB-))))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NN tyrosyl) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))))) (CC and) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN PTP-1CM))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Transient) (NN expression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (DT a) (JJ null) (NN mutant)) (PP (IN of) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN PTP-1CM)) (-RRB- -RRB-))))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NN tyrosyl) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))))) (CC and) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN PTP-1CM))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NN contrast))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBD was) (RB not) (ADJP (NN tyrosyl) (JJ phosphorylated))) (CC or) (VP (VBD associated) (PP (IN with) (NP (NN PTP-1CM))) (PP (IN in) (DT the) (NN presence) (IN of) (NP (JJ wild-type) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ C-terminal) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))))) (CC and) (VP (VBZ inhibits) (NP (PRP$ its) (JJ enzymatic) (NN activity)))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN report))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (NP (NP (DT the) (JJ stable) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT a) (JJ clathrin-coated) (NN vesicle) (NN complex)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (CONJP (RB not) (RB only)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ carboxyl-terminal) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CONJP (CC but) (RB also)) (VP (VBZ inhibits) (NP (PRP$ its) (JJ enzymatic) (NN activity)) (PP (IN in) (NP (DT a) (JJ dose-dependent) (NN manner)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN report))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (NP (NP (DT the) (JJ stable) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT a) (JJ clathrin-coated) (NN vesicle) (NN complex)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (CONJP (RB not) (RB only)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ carboxyl-terminal) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,) (CONJP (CC but) (RB also)) (VP (VBZ inhibits) (NP (PRP$ its) (JJ enzymatic) (NN activity)) (PP (IN in) (NP (DT a) (JJ dose-dependent) (NN manner)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN report))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (NP (NP (DT the) (JJ stable) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT a) (JJ clathrin-coated) (NN vesicle) (NN complex)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (CONJP (RB not) (RB only)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ carboxyl-terminal) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,) (CONJP (CC but) (RB also)) (VP (VBZ inhibits) (NP (PRP$ its) (JJ enzymatic) (NN activity)) (PP (IN in) (NP (DT a) (JJ dose-dependent) (NN manner)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN protein) (NN _PROT1_) (NNS functions)) (PP (IN in) (NP (DT a) (JJ multi-subunit) (NN E3) (NN ubiquitin) (NN ligase))) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (DT the) (JJ hypoxia-inducible) (NN transcription) (NN factor)) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN for) (NP (JJ proteasomal) (NN degradation))) (PP (IN during) (NP (NN normoxia))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP establish) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (NP (DT the) (NN 19S) (JJ regulatory) (NN complex)) (PP (IN of) (NP (DT the) (NN proteasome)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP establish) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (NP (DT the) (NN 19S) (JJ regulatory) (NN complex)) (PP (IN of) (NP (DT the) (NN proteasome)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP establish) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (NP (DT the) (NN 19S) (JJ regulatory) (NN complex)) (PP (IN of) (NP (DT the) (NN proteasome)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NP (DT the) (NN beta-domain)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (ADVP (FW in) (FW vivo))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NP (DT the) (NN beta-domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (ADVP (FW in) (FW vivo))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NP (DT the) (NN beta-domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (ADVP (FW in) (FW vivo))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NP (DT the) (NN beta-domain)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (ADVP (FW in) (FW vivo))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NP (DT the) (NN beta-domain)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (ADVP (FW in) (FW vivo))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NP (DT the) (NN beta-domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (ADVP (FW in) (FW vivo))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ promotes) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NP (DT a) (JJ pVHL-dependent) (NN manner)) (SBAR (WHNP (WDT that)) (S (VP (VBZ requires) (NP (NP (DT the) (NN ATPase) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ promotes) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (PP (IN in) (NP (NP (DT a) (JJ pVHL-dependent) (NN manner)) (SBAR (WHNP (WDT that)) (S (VP (VBZ requires) (NP (NP (DT the) (NN ATPase) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ promotes) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (PP (IN in) (NP (NP (DT a) (JJ pVHL-dependent) (NN manner)) (SBAR (WHNP (WDT that)) (S (VP (VBZ requires) (NP (NP (DT the) (NN ATPase) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Blockade)) (PP (IN of) (NP (NN _PROT1_) (NN expression))) (PP (IN by) (NP (NP (JJ small) (VBG interfering) (NN RNA)) (PRN (-LRB- -LRB-) (NP (NN siRNA)) (-RRB- -RRB-))))) (VP (VBZ causes) (NP (NP (JJ prolonged) (NN degradation) (NN kinetics)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Several) (JJ distinct) (NNS mutations)) (PP (IN in) (NP (NP (NN exon) (CD 2)) (PP (IN of) (NP (NNS _PROT1_)))))) (VP (VBP disrupt) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (NN _PROT_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Several) (JJ distinct) (NNS mutations)) (PP (IN in) (NP (NP (NN exon) (CD 2)) (PP (IN of) (NP (NNS _PROT1_)))))) (VP (VBP disrupt) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Several) (JJ distinct) (NNS mutations)) (PP (IN in) (NP (NP (NN exon) (CD 2)) (PP (IN of) (NP (NNS _PROT_)))))) (VP (VBP disrupt) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ _PROT1_) (NN mutant)) (VP (VBG containing) (NP (DT a) (NN P154L) (NN substitution)))) (VP (VP (VBZ coimmunoprecipitates) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,)))) (CC and) (VP (VBZ does) (RB not) (VP (VB promote) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ _PROT1_) (NN mutant)) (VP (VBG containing) (NP (DT a) (NN P154L) (NN substitution)))) (VP (VP (VBZ coimmunoprecipitates) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,)))) (CC and) (VP (VBZ does) (RB not) (VP (VB promote) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ _PROT1_) (NN mutant)) (VP (VBG containing) (NP (DT a) (NN P154L) (NN substitution)))) (VP (VP (VBZ coimmunoprecipitates) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,)))) (CC and) (VP (VBZ does) (RB not) (VP (VB promote) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ _PROT_) (NN mutant)) (VP (VBG containing) (NP (DT a) (NN P154L) (NN substitution)))) (VP (VP (VBZ coimmunoprecipitates) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,)))) (CC and) (VP (VBZ does) (RB not) (VP (VB promote) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ _PROT_) (NN mutant)) (VP (VBG containing) (NP (DT a) (NN P154L) (NN substitution)))) (VP (VP (VBZ coimmunoprecipitates) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,)))) (CC and) (VP (VBZ does) (RB not) (VP (VB promote) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ _PROT_) (NN mutant)) (VP (VBG containing) (NP (DT a) (NN P154L) (NN substitution)))) (VP (VP (VBZ coimmunoprecipitates) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)) (, ,)))) (CC and) (VP (VBZ does) (RB not) (VP (VB promote) (NP (NP (NN degradation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT2_) (NN _PROT2_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT_) (NNS tumors)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT_) (NN _PROT_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT_) (NN _PROT_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT_) (NN _PROT_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT2_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT1_) (NN _PROT1_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT1_) (NN _PROT1_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT1_) (NN _PROT1_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT2_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT_) (NN _PROT_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT1_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT_) (NNS tumors)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT_) (NN _PROT_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT1_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT2_) (NNS tumors)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB degrade) (NP (NN _PROT_) (NN _PROT_)))))) (VP (VP (VBZ depends) (PP (IN in) (NP (NN part))) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (CC and) (VP (VBZ suggests) (NP (NP (DT a) (JJ new) (NN mechanism)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN stabilization)) (PP (IN in) (NP (DT some) (JJ _PROT2_) (NNS tumors)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NP (DT the) (NN use)) (PP (IN of) (NP (DT the) (NN mAb) (NN MEM-53)))) (CC and) (NP (DT a) (JJ polyclonal) (NN sheep) (JJ anti-mouse) (NN Ig))))) (VP (VP (VBD promoted) (NP (NP (NN activation)) (PP (IN of) (NP (VBG resting) (NN B) (NNS cells))) (PP (IN into) (NP (NP (DT the) (NN G1) (NN phase)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle)))))) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (DT the) (JJ early) (NN activation) (NN Ag) (NN _PROT2_)))) (, ,) (NP (NP (NNS increases)) (PP (IN in) (NP (JJ cellular) (NN volume)))) (, ,) (NP (NN RNA) (NN synthesis)) (, ,) (CC and) (NP (NN _PROT_) (NN protein) (NNS levels)))))))) (, ,) (CC and) (VP (VBD enhanced) (NP (NP (NN binding)) (PP (IN of) (NP (NN 7-aminoactinomycin) (NN D)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NP (DT the) (NN use)) (PP (IN of) (NP (DT the) (NN mAb) (NN MEM-53)))) (CC and) (NP (DT a) (JJ polyclonal) (NN sheep) (JJ anti-mouse) (NN Ig))))) (VP (VP (VBD promoted) (NP (NP (NN activation)) (PP (IN of) (NP (VBG resting) (NN B) (NNS cells))) (PP (IN into) (NP (NP (DT the) (NN G1) (NN phase)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle)))))) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (DT the) (JJ early) (NN activation) (NN Ag) (NN _PROT_)))) (, ,) (NP (NP (NNS increases)) (PP (IN in) (NP (JJ cellular) (NN volume)))) (, ,) (NP (NN RNA) (NN synthesis)) (, ,) (CC and) (NP (NN _PROT2_) (NN protein) (NNS levels)))))))) (, ,) (CC and) (VP (VBD enhanced) (NP (NP (NN binding)) (PP (IN of) (NP (NN 7-aminoactinomycin) (NN D)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NP (DT the) (NN use)) (PP (IN of) (NP (DT the) (NN mAb) (NN MEM-53)))) (CC and) (NP (DT a) (JJ polyclonal) (NN sheep) (JJ anti-mouse) (NN Ig))))) (VP (VP (VBD promoted) (NP (NP (NN activation)) (PP (IN of) (NP (VBG resting) (NN B) (NNS cells))) (PP (IN into) (NP (NP (DT the) (NN G1) (NN phase)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle)))))) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (DT the) (JJ early) (NN activation) (NN Ag) (NN _PROT1_)))) (, ,) (NP (NP (NNS increases)) (PP (IN in) (NP (JJ cellular) (NN volume)))) (, ,) (NP (NN RNA) (NN synthesis)) (, ,) (CC and) (NP (NN _PROT2_) (NN protein) (NNS levels)))))))) (, ,) (CC and) (VP (VBD enhanced) (NP (NP (NN binding)) (PP (IN of) (NP (NN 7-aminoactinomycin) (NN D)))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NNS cytokines)) (, ,) (PP (IN in) (NP (JJ particular) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (VP (VBD potentiated) (NP (NP (DT the) (NN DNA) (NN synthesis)) (VP (VBN induced) (PP (IN by) (NP (NP (NN cross-linking)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NNS cytokines)) (, ,) (PP (IN in) (NP (JJ particular) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (VP (VBD potentiated) (NP (NP (DT the) (NN DNA) (NN synthesis)) (VP (VBN induced) (PP (IN by) (NP (NP (NN cross-linking)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NNS cytokines)) (, ,) (PP (IN in) (NP (JJ particular) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (VP (VBD potentiated) (NP (NP (DT the) (NN DNA) (NN synthesis)) (VP (VBN induced) (PP (IN by) (NP (NP (NN cross-linking)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NP (JJ human) (NN _PROT1_) (NN mRNA) (NN editing)) (NN protein)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT2_) (NN _PROT2_)) (VP (VBG showing) (NP (JJ structural) (NN homology)) (PP (TO to) (NP (DT some) (JJ known) (UCP (ADJP (JJ mammalian)) (CC and) (NP (NN bacteriophage))) (NN deoxycytidylate) (NNS deaminases)))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN fact) (SBAR (IN that) (S (NP (DT the) (NP (NN _PROT1_) (NN mRNA) (NN editing)) (NN protein)) (ADVP (RB also)) (VP (VBZ exists) (PP (IN as) (NP (DT a) (NN _PROT2_))))))) (VP (VBZ has) (NP (NP (JJ important) (NNS implications)) (PP (IN for) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NN _PROT_) (NN mRNA) (NN editing))) (PP (IN in) (NP (NNS humans))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN fact) (SBAR (IN that) (S (NP (DT the) (NP (NN _PROT1_) (NN mRNA) (NN editing)) (NN protein)) (ADVP (RB also)) (VP (VBZ exists) (PP (IN as) (NP (DT a) (NN _PROT_))))))) (VP (VBZ has) (NP (NP (JJ important) (NNS implications)) (PP (IN for) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NN _PROT2_) (NN mRNA) (NN editing))) (PP (IN in) (NP (NNS humans))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN fact) (SBAR (IN that) (S (NP (DT the) (NP (NN _PROT_) (NN mRNA) (NN editing)) (NN protein)) (ADVP (RB also)) (VP (VBZ exists) (PP (IN as) (NP (DT a) (NN _PROT1_))))))) (VP (VBZ has) (NP (NP (JJ important) (NNS implications)) (PP (IN for) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NN _PROT2_) (NN mRNA) (NN editing))) (PP (IN in) (NP (NNS humans))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NNS dimers)) (VP (VP (VBN formed) (PP (IN through) (NP (NP (NN self-association)) (PP (IN of) (NP (DT the) (JJ TATA-binding) (NN polypeptide) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN subunit)))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN _PROT_) (-LRB- _PROT_) (CD _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NP (DT the) (NN core) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NNS dimers)) (VP (VP (VBN formed) (PP (IN through) (NP (NP (NN self-association)) (PP (IN of) (NP (DT the) (JJ TATA-binding) (NN polypeptide) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN subunit)))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN _PROT2_) (-LRB- _PROT2_) (CD _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (, ,) (NP (NP (DT the) (NN core) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NNS dimers)) (VP (VP (VBN formed) (PP (IN through) (NP (NP (NN self-association)) (PP (IN of) (NP (DT the) (JJ TATA-binding) (NN polypeptide) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN subunit)))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN _PROT_) (-LRB- _PROT_) (CD _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NP (DT the) (NN core) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (NNS dimers)) (VP (VP (VBN formed) (PP (IN through) (NP (NP (NN self-association)) (PP (IN of) (NP (DT the) (JJ TATA-binding) (NN polypeptide) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN subunit)))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN _PROT2_) (-LRB- _PROT2_) (CD _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (, ,) (NP (NP (DT the) (NN core) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (NNS dimers)) (VP (VP (VBN formed) (PP (IN through) (NP (NP (NN self-association)) (PP (IN of) (NP (DT the) (JJ TATA-binding) (NN polypeptide) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN subunit)))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN _PROT_) (-LRB- _PROT_) (CD _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NP (DT the) (NN core) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_) (NNS dimers)) (VP (VP (VBN formed) (PP (IN through) (NP (NP (NN self-association)) (PP (IN of) (NP (DT the) (JJ TATA-binding) (NN polypeptide) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN subunit)))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (CD _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NP (DT the) (NN core) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NN beta-2) (JJ integrin-mediated) (NN adhesion)) (PP (IN through) (NP (CC both) (NP (JJ ARF-GEF) (NN function)) (CC and) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN of) (SBAR (WHADVP (WRB how)) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NP (DT an) (JJ integrin-binding) (NN protein)) (CC and) (NP (NP (JJ guanine-nucleotide) (NN exchange) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN GEF)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NNS GTPases)))) (, ,)) (VP (VBZ regulates) (NP (NN cell) (NN adhesion)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Mutational) (NNS analyses)) (PP (IN of) (NP (DT the) (NN beta-2) (JJ cytoplasmic) (NN domain)))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (DT the) (JJ adhesive) (NN function)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ depends) (PP (IN on) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (SBAR (IN unless) (S (NP (DT the) (NN integrin)) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (JJ exogenous) (JJ divalent) (NNS cations))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Secondly)) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (NP (NN expression)) (PP (IN of) (NP (NP (DT an) (JJ extracellular) (NN activation) (NN epitope)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,) (CC and) (S (NP (DT the) (NN exchange) (NN factor) (NN function)) (VP (VBZ is) (RB not) (ADJP (JJ essential) (PP (IN for) (NP (DT this) (NN activity))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NP (JJ LFA-1-mediated) (NN cell) (NN adhesion)) (CC and) (NP (NN spreading))) (PP (IN on) (NP (JJ intercellular) (NN cell) (NN adhesion) (NN molecule) (CD 1)))) (VP (VBZ is) (ADVP (RB strongly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (DT a) (NN _PROT1_) (NN mutant)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ fails) (S (VP (TO to) (VP (VB catalyze) (NP (NN _PROT2_) (NN GDP-GTP) (NN exchange)) (ADVP (FW in) (FW vitro)))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_))))) (, ,) (PP (ADVP (RBS most) (RB probably)) (IN through) (NP (NP (JJ direct) (NN interaction)) (PP (IN with) (NP (DT the) (NN integrin))))))) (, ,) (CC and) (VP (VBZ induces) (NP (NN cell) (NN spreading)) (PP (IN by) (NP (PRP$ its) (JJ ARF-GEF) (NN activity))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG constructing) (NP (NN deletion) (NNS mutants))))) (, ,) (NP (PRP we)) (VP (VBD identified) (SBAR (IN that) (S (S (NP (NP (NN amino) (NN acid) (NNS residues) (CD 229-309)) (PP (IN of) (NP (NN Akt)))) (VP (VBD were) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN binding)) (PP (TO to) (NP (NN _PROT1_)))))))) (CC and) (S (NP (NP (NN amino) (NN acid) (NNS residues) (CD 327-340)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD were) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN binding)) (PP (TO to) (NP (NN Akt))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (: :) (NP (JJ multifunctional) (JJ endocytic) (NNS receptors))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (NP (NP (CD two) (ADJP (RB structurally) (JJ different)) (JJ endocytic) (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (S (VP (TO to) (VP (VB serve) (NP (JJ such) (NNS functions)))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN MutS) (NN homolog) (CD 2)) (-RRB- -RRB-))) (NN protein)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN ATR) (PRN (-LRB- -LRB-) (ADJP (ADJP (JJ ATM-)) (CC and) (ADJP (JJ Rad3-related))) (-RRB- -RRB-)) (NN kinase))) (S (VP (TO to) (VP (VP (VP (VB form) (NP (DT a) (NN signaling) (NN module))) (CC and) (VP (VB regulate) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (PRN (-LRB- -LRB-) (NP (NP (NN structure) (NN maintenance)) (PP (IN of) (NP (NN chromosome) (CD 1)))) (-RRB- -RRB-))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN MutS) (NN homolog) (CD 2)) (-RRB- -RRB-))) (NN protein)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN ATR) (PRN (-LRB- -LRB-) (ADJP (ADJP (JJ ATM-)) (CC and) (ADJP (JJ Rad3-related))) (-RRB- -RRB-)) (NN kinase))) (S (VP (TO to) (VP (VP (VP (VB form) (NP (DT a) (NN signaling) (NN module))) (CC and) (VP (VB regulate) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (PRN (-LRB- -LRB-) (NP (NP (NN structure) (NN maintenance)) (PP (IN of) (NP (NN chromosome) (CD 1)))) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN MutS) (NN homolog) (CD 2)) (-RRB- -RRB-))) (NN protein)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN ATR) (PRN (-LRB- -LRB-) (ADJP (ADJP (JJ ATM-)) (CC and) (ADJP (JJ Rad3-related))) (-RRB- -RRB-)) (NN kinase))) (S (VP (TO to) (VP (VP (VP (VB form) (NP (DT a) (NN signaling) (NN module))) (CC and) (VP (VB regulate) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (PRN (-LRB- -LRB-) (NP (NP (NN structure) (NN maintenance)) (PP (IN of) (NP (NN chromosome) (CD 1)))) (-RRB- -RRB-))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN ATR)))) (ADVP (RB also)) (VP (VBZ requires) (NP (NN checkpoint) (NNS proteins) (CD _PROT2_) (CC and) (NP (NN replication) (NN protein) (NN A))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN ATR)))) (VP (VBZ is) (ADJP (JJ independent) (PP (IN of) (NP (NP (CD _PROT2_)) (CC and) (NP (NN replication) (NN protein) (NN A))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN signaling) (NN pathway)) (VP (VBG leading) (PP (TO to) (NP (NN _PROT_) (NN phosphorylation))))) (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN checkpoint) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN ATR)))) (VP (VBZ is) (ADJP (JJ independent) (PP (IN of) (NP (NP (CD _PROT_)) (CC and) (NP (NN replication) (NN protein) (NN A))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN signaling) (NN pathway)) (VP (VBG leading) (PP (TO to) (NP (NN _PROT2_) (NN phosphorylation))))) (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN checkpoint) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN ATR)))) (VP (VBZ is) (ADJP (JJ independent) (PP (IN of) (NP (NP (CD _PROT1_)) (CC and) (NP (NN replication) (NN protein) (NN A))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN signaling) (NN pathway)) (VP (VBG leading) (PP (TO to) (NP (NN _PROT2_) (NN phosphorylation))))) (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN checkpoint) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (S (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (CD _PROT2_))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NN S-phase) (NN checkpoint))) (S (VP (TO to) (VP (VB suppress) (NP (NN DNA) (NN synthesis)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN MNNG))))))))))))) (, ,) (CC and) (S (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (JJ cellular) (NN survival))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (S (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (CD _PROT_))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NN S-phase) (NN checkpoint))) (S (VP (TO to) (VP (VB suppress) (NP (NN DNA) (NN synthesis)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN MNNG))))))))))))) (, ,) (CC and) (S (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (JJ cellular) (NN survival))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (S (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (CD _PROT1_))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NN S-phase) (NN checkpoint))) (S (VP (TO to) (VP (VB suppress) (NP (NN DNA) (NN synthesis)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN MNNG))))))))))))) (, ,) (CC and) (S (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (JJ cellular) (NN survival))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Assignment)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN Etfa)))) (PP (TO to) (NP (NNS chromosomes) (QP (CD 3) (, ,) (CD 7) (, ,) (CC and) (CD 13))))) (: :) (NP (NP (DT the) (NN mouse) (NNS homologs)) (PP (IN of) (NP (NP (NNS genes)) (ADJP (JJ responsible) (PP (IN for) (NP (JJ glutaric) (NN acidemia) (NN type) (CD II)))))) (PP (IN in) (NP (JJ human)))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN cDNA) (NNS probes)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN Etfa))) (NNS genes)))) (S (VP (TO to) (VP (VB determine) (NP (NP (NN localization)) (PP (IN of) (NP (DT these) (NN mouse) (NNS genes))) (PP (TO to) (NP (NNS chromosomes) (NP (NP (CD 3)) (, ,) (NP (CD 7)) (, ,) (CC and) (NP (CD 13)))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VP (VBP demonstrate) (NP (NN colocalization))) (CC and) (VP (VBP direct) (NP (NP (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ results) (PP (IN in) (NP (NP (NP (DT a) (NN zinc) (JJ finger-dependent) (NN localization)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN isoform)))) (CC and) (NP (NP (NN dynactin)) (PP (TO to) (NP (NN MT) (NNS bundles)))))) (, ,) (S (VP (VBG raising) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP regulate) (NP (NP (NN dynein/dynactin) (NN binding)) (PP (TO to) (NP (NNS MTs))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ results) (PP (IN in) (NP (NP (NP (DT a) (NN zinc) (JJ finger-dependent) (NN localization)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN isoform)))) (CC and) (NP (NP (NN dynactin)) (PP (TO to) (NP (NN MT) (NNS bundles)))))) (, ,) (S (VP (VBG raising) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP regulate) (NP (NP (NN dynein/dynactin) (NN binding)) (PP (TO to) (NP (NNS MTs))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ results) (PP (IN in) (NP (NP (NP (DT a) (NN zinc) (JJ finger-dependent) (NN localization)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN isoform)))) (CC and) (NP (NP (NN dynactin)) (PP (TO to) (NP (NN MT) (NNS bundles)))))) (, ,) (S (VP (VBG raising) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP regulate) (NP (NP (NN dynein/dynactin) (NN binding)) (PP (TO to) (NP (NNS MTs))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (NP (DT a) (NN zinc) (JJ finger-dependent) (NN localization)) (PP (IN of) (NP (DT a) (NN _PROT1_) (NN isoform)))) (CC and) (NP (NP (NN dynactin)) (PP (TO to) (NP (NN MT) (NNS bundles)))))) (, ,) (S (VP (VBG raising) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP regulate) (NP (NP (NN dynein/dynactin) (NN binding)) (PP (TO to) (NP (NNS MTs))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (NP (DT a) (NN zinc) (JJ finger-dependent) (NN localization)) (PP (IN of) (NP (DT a) (NN _PROT1_) (NN isoform)))) (CC and) (NP (NP (NN dynactin)) (PP (TO to) (NP (NN MT) (NNS bundles)))))) (, ,) (S (VP (VBG raising) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP regulate) (NP (NP (NN dynein/dynactin) (NN binding)) (PP (TO to) (NP (NNS MTs))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (NP (DT a) (NN zinc) (JJ finger-dependent) (NN localization)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN isoform)))) (CC and) (NP (NP (NN dynactin)) (PP (TO to) (NP (NN MT) (NNS bundles)))))) (, ,) (S (VP (VBG raising) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP regulate) (NP (NP (NN dynein/dynactin) (NN binding)) (PP (TO to) (NP (NNS MTs))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ regulated) (NN adapter)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ cytoplasmic) (NN dynein)))) (PP (PP (IN at) (NP (NP (NNS sites)) (VP (VBN involved) (PP (IN in) (NP (NN cargo-MT) (NN loading)))))) (, ,) (CC and/or) (PP (IN in) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NN MT) (NNS dynamics))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN II) (NN isozyme)) (-RRB- -RRB-))) (VP (VBZ contains) (NP (NP (NP (DT a) (NN _PROT2_) (NN homology) (NN domain)) (PP (IN at) (NP (DT the) (NN N) (NN terminus)))) (CC and) (NP (NP (DT a) (JJ sterile) (NN alpha) (NN motif) (NN domain)) (PP (IN at) (NP (DT the) (NN C) (NN terminus)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN binding)) (PP (IN of) (NP (NP (JJ vascular) (JJ cell-derived) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (DT the) (NN beta-amyloid) (NN protein)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN binding)) (PP (IN of) (NP (NP (JJ vascular) (JJ cell-derived) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (DT the) (NN beta-amyloid) (NN protein)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN binding)) (PP (IN of) (NP (NP (JJ vascular) (JJ cell-derived) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (DT the) (NN beta-amyloid) (NN protein)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN binding)) (PP (IN of) (NP (NP (JJ vascular) (JJ cell-derived) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (DT the) (NN beta-amyloid) (NN protein)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN binding)) (PP (IN of) (NP (NP (JJ vascular) (JJ cell-derived) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (DT the) (NN beta-amyloid) (NN protein)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN binding)) (PP (IN of) (NP (NP (JJ vascular) (JJ cell-derived) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (DT the) (NN beta-amyloid) (NN protein)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (NP (NP (DT the) (NN immunolocalization)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ specific) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN protein) (PRN (-LRB- -LRB-) (NP (NN A) (NN beta)) (-RRB- -RRB-)) (JJ -containing) (NN _PROT_) (NNS deposits)) (PP (IN within) (NP (NP (DT the) (NNS walls)) (PP (IN of) (NP (NP (NN blood) (NNS vessels)) (PRN (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ congophilic) (NN angiopathy))) (-RRB- -RRB-)))))) (PP (IN in) (NP (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (NN brain)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (NP (NP (DT the) (NN immunolocalization)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ specific) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN protein) (PRN (-LRB- -LRB-) (NP (NN A) (NN beta)) (-RRB- -RRB-)) (JJ -containing) (NN _PROT_) (NNS deposits)) (PP (IN within) (NP (NP (DT the) (NNS walls)) (PP (IN of) (NP (NP (NN blood) (NNS vessels)) (PRN (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ congophilic) (NN angiopathy))) (-RRB- -RRB-)))))) (PP (IN in) (NP (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (NN brain)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (NP (NP (DT the) (NN immunolocalization)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ specific) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN protein) (PRN (-LRB- -LRB-) (NP (NN A) (NN beta)) (-RRB- -RRB-)) (JJ -containing) (NN _PROT2_) (NNS deposits)) (PP (IN within) (NP (NP (DT the) (NNS walls)) (PP (IN of) (NP (NP (NN blood) (NNS vessels)) (PRN (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ congophilic) (NN angiopathy))) (-RRB- -RRB-)))))) (PP (IN in) (NP (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (NN brain)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (NP (NP (DT the) (NN immunolocalization)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ specific) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN protein) (PRN (-LRB- -LRB-) (NP (NN A) (NN beta)) (-RRB- -RRB-)) (JJ -containing) (NN _PROT_) (NNS deposits)) (PP (IN within) (NP (NP (DT the) (NNS walls)) (PP (IN of) (NP (NP (NN blood) (NNS vessels)) (PRN (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ congophilic) (NN angiopathy))) (-RRB- -RRB-)))))) (PP (IN in) (NP (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (NN brain)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (NP (NP (DT the) (NN immunolocalization)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ specific) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN protein) (PRN (-LRB- -LRB-) (NP (NN A) (NN beta)) (-RRB- -RRB-)) (JJ -containing) (NN _PROT2_) (NNS deposits)) (PP (IN within) (NP (NP (DT the) (NNS walls)) (PP (IN of) (NP (NP (NN blood) (NNS vessels)) (PRN (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ congophilic) (NN angiopathy))) (-RRB- -RRB-)))))) (PP (IN in) (NP (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (NN brain)))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (NP (NP (DT the) (NN immunolocalization)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ specific) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,))) (PP (TO to) (NP (NP (DT the) (NN _PROT1_) (NN protein) (PRN (-LRB- -LRB-) (NP (NN A) (NN beta)) (-RRB- -RRB-)) (JJ -containing) (NN _PROT2_) (NNS deposits)) (PP (IN within) (NP (NP (DT the) (NNS walls)) (PP (IN of) (NP (NP (NN blood) (NNS vessels)) (PRN (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ congophilic) (NN angiopathy))) (-RRB- -RRB-)))))) (PP (IN in) (NP (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (NN brain)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (DT the) (NNS results)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (JJ specific) (JJ vascular) (JJ cell-derived) (NNS _PROT1_)) (ADVP (RB differentially)) (VP (VBP interact) (PP (IN with) (NP (NN A) (NN beta)))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (JJS highest) (NN affinity)))) (VP (VBP occur) (PP (IN between) (NP (NP (NP (NN A) (NN beta)) (CC and) (NP (NN binding) (NNS sites))) (PP (IN on) (NP (CC both) (NP (DT the) (NN core) (NN protein)) (CC and) (NP (NP (NN glycosaminoglycan) (NNS chains)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN investigation))) (, ,) (NP (NP (DT the) (JJ differential) (NN binding)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (ADJP (NP (NP (JJ endothelial) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN EC)) (-RRB- -RRB-)) (: -) (CC and) (NP (NP (JJ smooth) (NN muscle) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (JJ -derived)) (NNS _PROT2_))) (PP (TO to) (NP (NN A) (NN beta)))) (VP (VBD was) (VP (VBN examined) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN A) (NN beta))) (PP (IN in) (NP (JJ cerebrovascular) (NN _PROT_) (NNS deposits)))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (NN _PROT_))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN investigation))) (, ,) (NP (NP (DT the) (JJ differential) (NN binding)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (ADJP (NP (NP (JJ endothelial) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN EC)) (-RRB- -RRB-)) (: -) (CC and) (NP (NP (JJ smooth) (NN muscle) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (JJ -derived)) (NNS _PROT_))) (PP (TO to) (NP (NN A) (NN beta)))) (VP (VBD was) (VP (VBN examined) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN A) (NN beta))) (PP (IN in) (NP (JJ cerebrovascular) (NN _PROT2_) (NNS deposits)))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (NN _PROT_))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN investigation))) (, ,) (NP (NP (DT the) (JJ differential) (NN binding)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (ADJP (NP (NP (JJ endothelial) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN EC)) (-RRB- -RRB-)) (: -) (CC and) (NP (NP (JJ smooth) (NN muscle) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (JJ -derived)) (NNS _PROT_))) (PP (TO to) (NP (NN A) (NN beta)))) (VP (VBD was) (VP (VBN examined) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN A) (NN beta))) (PP (IN in) (NP (JJ cerebrovascular) (NN _PROT_) (NNS deposits)))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (NN _PROT2_))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN investigation))) (, ,) (NP (NP (DT the) (JJ differential) (NN binding)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (ADJP (NP (NP (JJ endothelial) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN EC)) (-RRB- -RRB-)) (: -) (CC and) (NP (NP (JJ smooth) (NN muscle) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (JJ -derived)) (NNS _PROT1_))) (PP (TO to) (NP (NN A) (NN beta)))) (VP (VBD was) (VP (VBN examined) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN A) (NN beta))) (PP (IN in) (NP (JJ cerebrovascular) (NN _PROT2_) (NNS deposits)))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (NN _PROT_))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN investigation))) (, ,) (NP (NP (DT the) (JJ differential) (NN binding)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (ADJP (NP (NP (JJ endothelial) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN EC)) (-RRB- -RRB-)) (: -) (CC and) (NP (NP (JJ smooth) (NN muscle) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (JJ -derived)) (NNS _PROT1_))) (PP (TO to) (NP (NN A) (NN beta)))) (VP (VBD was) (VP (VBN examined) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN A) (NN beta))) (PP (IN in) (NP (JJ cerebrovascular) (NN _PROT_) (NNS deposits)))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (NN _PROT2_))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN investigation))) (, ,) (NP (NP (DT the) (JJ differential) (NN binding)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (ADJP (NP (NP (JJ endothelial) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN EC)) (-RRB- -RRB-)) (: -) (CC and) (NP (NP (JJ smooth) (NN muscle) (NN cell)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (JJ -derived)) (NNS _PROT_))) (PP (TO to) (NP (NN A) (NN beta)))) (VP (VBD was) (VP (VBN examined) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN A) (NN beta))) (PP (IN in) (NP (JJ cerebrovascular) (NN _PROT1_) (NNS deposits)))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (NN _PROT2_))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN AA) (JJ amyloidotic) (UCP (ADJP (JJ splenic)) (CC and) (NP (NN liver))) (NN tissue) (NNS sections))) (PP (IN with) (NP (NP (JJ synthetic) (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-))))) (VP (VBD produced) (NP (JJ strong) (NN immunoreactivity)) (PP (IN with) (NP (NN A) (NN beta) (NNS antibodies))) (PP (IN at) (NP (NP (NN tissue) (NNS sites)) (VP (VBN enriched) (PP (IN in) (NP (NP (NN _PROT1_)) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADVP (RB partially)) (VP (VBN removed) (PP (PP (IN by) (NP (NP (NN pretreatment)) (PP (IN with) (NP (NN heparitinase))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NN chondroitin) (NN _PROT2_) (NN lyase)))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (LST (LS [35S) (-RRB- -RSB-)) (NP (JJ -Sulfate) (JJ labeled) (NNS proteoglycans)) (PRN (-LRB- -LRB-) (NP (NNS _PROT1_)) (-RRB- -RRB-)) (VP (VBN derived) (PP (IN from) (NP (VBN cultured) (NP (NNS ECs)) (CC and) (NP (NNS SMCs)))))) (VP (VBD bound) (PP (TO to) (NP (NP (NN affinity) (NNS columns)) (VP (VBG containing) (NP (NP (DT A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)) (CC or) (PRN (-LRB- -LRB-) (NP (NN 1-40)) (-RRB- -RRB-)))))) (, ,) (PP (IN with) (NP (NP (ADJP (RB virtually) (DT no)) (NN binding)) (PP (TO to) (NP (NP (NP (NP (DT A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 40-1)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN reverse) (NN peptide)) (-RRB- -RRB-))) (, ,) (NP (NP (NN beta-amyloid) (NN precursor) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN 410-429)) (-RRB- -RRB-))) (, ,) (CC or) (NP (JJ bovine) (NN _PROT2_) (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT1_))) (NNS _PROT2_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT1_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT2_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT1_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT1_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT1_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT1_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT2_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT1_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT1_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT1_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT1_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (NP (NN EC)) (CC and) (NP (NN _PROT_))) (NNS _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (NN A) (NN beta)) (PRN (-LRB- -LRB-) (NP (NN 1-28)) (-RRB- -RRB-)))))))) (VP (VBD revealed) (NP (NP (NP (JJ strong) (NN binding)) (PP (IN by) (NP (NN _PROT_)))) (, ,) (NP (NP (JJ weak) (NN binding)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (NP (CD two) (NN dermatan) (NN sulfate) (NNS proteoglycans)) (, ,) (CC and) (NP (NP (NN lack)) (PP (IN of) (NP (NP (NN binding)) (PP (IN by) (NP (NP (NN _PROT1_AND_PROT2_)) (, ,) (NP (DT a) (JJ large) (NN chondroitin) (NN sulfate) (NN proteoglycan))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Herein)) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT a) (JJ distinct) (NN IkappaB) (NN protein) (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN RXR))) (, ,) (SBAR (IN as) (S (VP (VBN shown) (PP (IN in) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NNS tests)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (JJ pull-down) (NNS assays))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (NN _PROT1_))))) (, ,) (NP (NN _PROT2_)) (VP (VBD did) (RB not) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN AF2) (NN domain)) (PP (IN of) (NP (NN RXR))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBD interacted) (PP (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NNS factors) (NP (NP (NN _PROT2_)) (, ,) (NP (NN TBP)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (PP (RB not) (IN with) (NP (NN TFIIEalpha)))) (PP (IN in) (NP (DT the) (NN _PROT_) (JJ pull-down) (NNS assays)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBD interacted) (PP (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NNS factors) (NP (NP (NN _PROT_)) (, ,) (NP (NN TBP)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (PP (RB not) (IN with) (NP (NN TFIIEalpha)))) (PP (IN in) (NP (DT the) (NN _PROT_) (JJ pull-down) (NNS assays)))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBD interacted) (PP (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NNS factors) (NP (NP (NN _PROT_)) (, ,) (NP (NN TBP)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (PP (RB not) (IN with) (NP (NN TFIIEalpha)))) (PP (IN in) (NP (DT the) (NN _PROT2_) (JJ pull-down) (NNS assays)))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBD interacted) (PP (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NNS factors) (NP (NP (NN _PROT1_)) (, ,) (NP (NN TBP)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (PP (RB not) (IN with) (NP (NN TFIIEalpha)))) (PP (IN in) (NP (DT the) (NN _PROT_) (JJ pull-down) (NNS assays)))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBD interacted) (PP (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NNS factors) (NP (NP (NN _PROT1_)) (, ,) (NP (NN TBP)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (PP (RB not) (IN with) (NP (NN TFIIEalpha)))) (PP (IN in) (NP (DT the) (NN _PROT2_) (JJ pull-down) (NNS assays)))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBD interacted) (PP (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NNS factors) (NP (NP (NN _PROT_)) (, ,) (NP (NN TBP)) (, ,) (CC and) (NP (NN _PROT1_))))) (CC but) (PP (RB not) (IN with) (NP (NN TFIIEalpha)))) (PP (IN in) (NP (DT the) (NN _PROT2_) (JJ pull-down) (NNS assays)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN TBP)) (CC and) (NP (NN _PROT1_))) (, ,) (ADVP (RB however)) (, ,) (VP (VBD were) (RB not) (ADJP (JJ able) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Accordingly)) (, ,) (NP (NN _PROT1_)) (VP (VBN coactivated) (NP (NP (DT the) (JJ 9-cis-RA-induced) (NNS transactivations)) (PP (IN of) (NP (NN RXR)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ inhibitory) (NNS actions)) (PP (IN of) (NP (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))))) (ADVP (RB further)) (VP (VBD stimulated) (NP (NP (DT the) (JJ Bcl3-mediated) (NN enhancement)) (PP (IN of) (NP (NP (DT the) (JJ 9-cis-RA-induced) (NNS transactivations)) (PP (IN of) (NP (NN RXR))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN solution))) (, ,) (NP (NN FGFR4ed)) (VP (VBD formed) (NP (NNS complexes)) (PP (PP (IN with) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))) (, ,) (CC both) (PP (IN in) (NP (NP (DT the) (NP (NN presence)) (CC and) (NP (NN absence))) (PP (IN of) (NP (NN heparin))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Immobilized) (NN _PROT1_)) (ADVP (RB also)) (VP (VBD bound) (NP (NN _PROT2_)) (PP (IN besides) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Immobilized) (NN _PROT1_)) (ADVP (RB also)) (VP (VBD bound) (NP (NN _PROT_)) (PP (IN besides) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Immobilized) (NN _PROT1_)) (ADVP (RB also)) (VP (VBD bound) (NP (NN _PROT_)) (PP (IN besides) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Immobilized) (NN _PROT_)) (ADVP (RB also)) (VP (VBD bound) (NP (NN _PROT1_)) (PP (IN besides) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Immobilized) (NN _PROT_)) (ADVP (RB also)) (VP (VBD bound) (NP (NN _PROT1_)) (PP (IN besides) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Immobilized) (NN _PROT_)) (ADVP (RB also)) (VP (VBD bound) (NP (NN _PROT_)) (PP (IN besides) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Physical) (NN association)) (PP (IN of) (NP (NN _PROT1_) (CD _PROT1_) (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ novel) (JJ glycosylphosphatidylinositol-anchored) (NN protein)) (PP (IN with) (NP (NN potential))) (PP (IN for) (S (VP (VBG regulating) (NP (NP (NN adhesion)) (CC and) (NP (NN migration)))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (VP (VB clarify) (NP (NP (DT the) (NNS mechanisms)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN on) (NP (NNS leukocytes)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD explored) (NP (NP (DT the) (NN possibility)) (PP (IN of) (NP (NP (PRP$ its) (JJ physical) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ important) (PP (IN for) (NP (NP (NN leukocyte) (NN adherence)) (, ,) (NP (NN locomotion)) (, ,) (CC and) (NP (NN extravasation))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN detected) (PP (IN by) (NP (JJ anti-CD18) (NN mAb)))) (, ,)) (VP (VBD was) (VP (VBD coprecipitated) (PP (IN with) (NP (NN _PROT2_))) (PP (IN from) (NP (JJ human) (NN neutrophil) (NNS lysates))) (PP (IN by) (NP (NP (DT a) (NN mAb)) (PP (TO to) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN detected) (PP (IN by) (NP (JJ anti-CD18) (NN mAb)))) (, ,)) (VP (VBD was) (VP (VBD coprecipitated) (PP (IN with) (NP (NN _PROT_))) (PP (IN from) (NP (JJ human) (NN neutrophil) (NNS lysates))) (PP (IN by) (NP (NP (DT a) (NN mAb)) (PP (TO to) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (CD _PROT_) (NN _PROT_)) (, ,) (VP (VBN detected) (PP (IN by) (NP (JJ anti-CD18) (NN mAb)))) (, ,)) (VP (VBD was) (VP (VBD coprecipitated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN from) (NP (JJ human) (NN neutrophil) (NNS lysates))) (PP (IN by) (NP (NP (DT a) (NN mAb)) (PP (TO to) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN immunoprecipitated) (PP (IN from) (NP (JJ human) (NN neutrophil) (NNS lysates))) (PP (IN by) (NP (JJ anti-human) (NN _PROT2_) (NN mAb))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB physically)) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PP (IN in) (NP (JJ human) (NNS neutrophils)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN orphan) (NN receptor)) (VP (VBZ functions) (PP (IN as) (NP (NP (JJ negative) (NN modulator)) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_))))) (PP (IN in) (NP (NN prostate) (NN cancer) (NNS cells))))) (NP (NN _PROT_))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN orphan) (NN receptor)) (VP (VBZ functions) (PP (IN as) (NP (NP (JJ negative) (NN modulator)) (PP (IN for) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN in) (NP (NN prostate) (NN cancer) (NNS cells))))) (NP (NN _PROT2_))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT_) (NN orphan) (NN receptor)) (VP (VBZ functions) (PP (IN as) (NP (NP (JJ negative) (NN modulator)) (PP (IN for) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN in) (NP (NN prostate) (NN cancer) (NNS cells))))) (NP (NN _PROT2_))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (NP (CC Both) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AR)) (-RRB- -RRB-))) (CC and) (NP (NP (NN orphan) (NN receptor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP belong) (PP (TO to) (NP (DT the) (NN steroid) (JJ nuclear) (NN receptor) (NN superfamily)))) (CC and) (VP (VBP are) (VP (VBN expressed) (PP (IN in) (NP (NP (NN prostate) (NN cancer) (NN tissue)) (CC and) (NP (NN cell) (NNS lines))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (NP (CC Both) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AR)) (-RRB- -RRB-))) (CC and) (NP (NP (NN orphan) (NN receptor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VP (VBP belong) (PP (TO to) (NP (DT the) (NN steroid) (JJ nuclear) (NN receptor) (NN superfamily)))) (CC and) (VP (VBP are) (VP (VBN expressed) (PP (IN in) (NP (NP (NN prostate) (NN cancer) (NN tissue)) (CC and) (NP (NN cell) (NNS lines))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (NP (CC Both) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN AR)) (-RRB- -RRB-))) (CC and) (NP (NP (NN orphan) (NN receptor) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VP (VBP belong) (PP (TO to) (NP (DT the) (NN steroid) (JJ nuclear) (NN receptor) (NN superfamily)))) (CC and) (VP (VBP are) (VP (VBN expressed) (PP (IN in) (NP (NP (NN prostate) (NN cancer) (NN tissue)) (CC and) (NP (NN cell) (NNS lines))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN AR)) (CC and) (NP (NN _PROT1_))))) (VP (VBD was) (VP (VBN assessed) (PP (IN by) (NP (NP (ADJP (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ pull-down)) (NN assay)) (CC and) (NP (JJ mammalian) (JJ two-hybrid) (NN system) (NN assay)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN AR)) (CC and) (NP (NN _PROT1_))))) (VP (VBD was) (VP (VBN assessed) (PP (IN by) (NP (NP (ADJP (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ pull-down)) (NN assay)) (CC and) (NP (JJ mammalian) (JJ two-hybrid) (NN system) (NN assay)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN AR)) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN assessed) (PP (IN by) (NP (NP (ADJP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ pull-down)) (NN assay)) (CC and) (NP (JJ mammalian) (JJ two-hybrid) (NN system) (NN assay)))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NP (NN PLZF)) (, ,) (CC and) (NP (NP (DT a) (ADJP (RB structurally) (JJ similar)) (JJ transcriptional) (NN repressor)) (, ,) (NP (NN _PROT1_)) (, ,))) (VP (MD can) (VP (VB interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ corepressor) (NNS proteins)) (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NN SMRT))))) (, ,) (PP (VBG including) (NP (NP (DT the) (NN mSin3A) (NN protein)) (CC and) (NP (PRN (-LRB- -LRB-) (PP (IN for) (NP (NN PLZF))) (-RRB- -RRB-)) (NN _PROT2_) (NN _PROT2_))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NP (CD two) (ADJP (RB evolutionarily) (VBN conserved)) (NNS subunits)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_)))))) (CC and) (NP (NP (PRP$ their) (NN involvement)) (PP (IN in) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (NN TFIIIB)) (CC and) (NP (NN RNA) (NN polymerase) (CD III)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NP (CD two) (ADJP (RB evolutionarily) (VBN conserved)) (NNS subunits)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT2_)))))) (CC and) (NP (NP (PRP$ their) (NN involvement)) (PP (IN in) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (NN TFIIIB)) (CC and) (NP (NN RNA) (NN polymerase) (CD III)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NP (CD two) (ADJP (RB evolutionarily) (VBN conserved)) (NNS subunits)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT2_)))))) (CC and) (NP (NP (PRP$ their) (NN involvement)) (PP (IN in) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (NN TFIIIB)) (CC and) (NP (NN RNA) (NN polymerase) (CD III)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT2_))) (VP (VBP are) (NP (NP (NN _PROT_) (NN kinase) (NNS inhibitors)) (PP (IN with) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (NP (NP (NP (NN S)) (CC and) (NP (NN G2/M))) (NN cell) (NN cycle) (NNS checkpoints)) (VP (VBN induced) (PP (IN by) (NP (JJ genotoxic) (NN stress)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT_))) (VP (VBP are) (NP (NP (NN _PROT2_) (NN kinase) (NNS inhibitors)) (PP (IN with) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (NP (NP (NP (NN S)) (CC and) (NP (NN G2/M))) (NN cell) (NN cycle) (NNS checkpoints)) (VP (VBN induced) (PP (IN by) (NP (JJ genotoxic) (NN stress)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT1_))) (VP (VBP are) (NP (NP (NN _PROT2_) (NN kinase) (NNS inhibitors)) (PP (IN with) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (NP (NP (NP (NN S)) (CC and) (NP (NN G2/M))) (NN cell) (NN cycle) (NNS checkpoints)) (VP (VBN induced) (PP (IN by) (NP (JJ genotoxic) (NN stress)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (NP (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (, ,) (CC and) (NP (NNP _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (, ,) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ acidic))) (, ,) (NP (JJ nuclear) (NNS proteins)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ terminal) (NN differentiation)) (, ,) (NP (NN growth) (NN suppression)) (, ,) (CC and) (NP (NN apoptosis))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Recent) (NN evidence)) (VP (VBZ has) (VP (VBN implicated) (NP (NN _PROT1_)) (PP (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NN _PROT2_) (NN kinase))))) (CC and) (PP (IN in) (NP (NN G2/M) (NN cell) (NN cycle) (NN arrest)))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Yet)) (, ,) (SBAR (IN whether) (S (NP (NP (NN _PROT1_)) (CC and/or) (NP (NNP _PROT2_))) (VP (VP (VBP function) (PP (IN as) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (NN _PROT_) (NN kinase)))))) (CC and/or) (VP (VBP play) (NP (DT a) (NN role)) (PP (IN in) (NP (NN G2/M) (NN cell) (NN cycle) (NN arrest))))))) (VP (VBZ has) (RB not) (VP (VBN been) (ADVP (RB fully)) (VP (VBN established)))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Yet)) (, ,) (SBAR (IN whether) (S (NP (NP (NN _PROT1_)) (CC and/or) (NP (NNP _PROT_))) (VP (VP (VBP function) (PP (IN as) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (NN _PROT2_) (NN kinase)))))) (CC and/or) (VP (VBP play) (NP (DT a) (NN role)) (PP (IN in) (NP (NN G2/M) (NN cell) (NN cycle) (NN arrest))))))) (VP (VBZ has) (RB not) (VP (VBN been) (ADVP (RB fully)) (VP (VBN established)))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Yet)) (, ,) (SBAR (IN whether) (S (NP (NP (NN _PROT_)) (CC and/or) (NP (NNP _PROT1_))) (VP (VP (VBP function) (PP (IN as) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (NN _PROT2_) (NN kinase)))))) (CC and/or) (VP (VBP play) (NP (DT a) (NN role)) (PP (IN in) (NP (NN G2/M) (NN cell) (NN cycle) (NN arrest))))))) (VP (VBZ has) (RB not) (VP (VBN been) (ADVP (RB fully)) (VP (VBN established)))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN work))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT2_))) (ADVP (RB specifically)) (VP (VBP interact) (PP (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))) (, ,) (CC but) (PP (RB not) (IN with) (NP (JJ other) (NN Cdk/Cyclin) (NNS complexes)))) (, ,) (ADVP (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN work))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT_))) (ADVP (RB specifically)) (VP (VBP interact) (PP (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex))) (, ,) (CC but) (PP (RB not) (IN with) (NP (JJ other) (NN Cdk/Cyclin) (NNS complexes)))) (, ,) (ADVP (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN work))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT1_))) (ADVP (RB specifically)) (VP (VBP interact) (PP (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex))) (, ,) (CC but) (PP (RB not) (IN with) (NP (JJ other) (NN Cdk/Cyclin) (NNS complexes)))) (, ,) (ADVP (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT2_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT2_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NNP _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT1_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT2_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT1_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT1_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT1_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT1_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Data)) (ADVP (RB also)) (VP (VBZ has) (VP (VBN been) (VP (VBN obtained) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NNP _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NN _PROT_)) (, ,)) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN cyclinB1)))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (DT the) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN kinase) (NN activity))) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB involve) (NP (NP (NN disruption)) (PP (IN of) (NP (DT the) (NN complex)))))))))) (, ,) (IN whereas) (S (NP (NNP _PROT_)) (VP (VBD did) (RB not) (VP (VB disrupt) (NP (DT the) (NN complex))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN kinase) (NN activity))) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB involve) (NP (NP (NN disruption)) (PP (IN of) (NP (DT the) (NN complex)))))))))) (, ,) (IN whereas) (S (NP (NNP _PROT_)) (VP (VBD did) (RB not) (VP (VB disrupt) (NP (DT the) (NN complex))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN kinase) (NN activity))) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB involve) (NP (NP (NN disruption)) (PP (IN of) (NP (DT the) (NN complex)))))))))) (, ,) (IN whereas) (S (NP (NNP _PROT2_)) (VP (VBD did) (RB not) (VP (VB disrupt) (NP (DT the) (NN complex))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT_) (NN kinase) (NN activity))) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB involve) (NP (NP (NN disruption)) (PP (IN of) (NP (DT the) (NN complex)))))))))) (, ,) (IN whereas) (S (NP (NNP _PROT_)) (VP (VBD did) (RB not) (VP (VB disrupt) (NP (DT the) (NN complex))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT_) (NN kinase) (NN activity))) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB involve) (NP (NP (NN disruption)) (PP (IN of) (NP (DT the) (NN complex)))))))))) (, ,) (IN whereas) (S (NP (NNP _PROT2_)) (VP (VBD did) (RB not) (VP (VB disrupt) (NP (DT the) (NN complex))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT_) (NN kinase) (NN activity))) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB involve) (NP (NP (NN disruption)) (PP (IN of) (NP (DT the) (NN complex)))))))))) (, ,) (IN whereas) (S (NP (NNP _PROT2_)) (VP (VBD did) (RB not) (VP (VB disrupt) (NP (DT the) (NN complex))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN tyrosine) (NN kinase) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB physically)) (VP (VBN associated) (PP (IN with) (NP (DT the) (NP (NP (NN Type) (CD I) (NN interferon)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN receptor) (NN complex))))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN activated) (PP (IN during) (NP (NN _PROT_) (NN _PROT_) (NN stimulation)))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN tyrosine) (NN kinase) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB physically)) (VP (VBN associated) (PP (IN with) (NP (DT the) (NP (NP (NN Type) (CD I) (NN interferon)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN receptor) (NN complex))))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN activated) (PP (IN during) (NP (NN _PROT2_) (NN _PROT2_) (NN stimulation)))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN tyrosine) (NN kinase) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB physically)) (VP (VBN associated) (PP (IN with) (NP (DT the) (NP (NP (NN Type) (CD I) (NN interferon)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN receptor) (NN complex))))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN activated) (PP (IN during) (NP (NN _PROT2_) (NN _PROT2_) (NN stimulation)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NN _PROT2_) (NN phosphatase) (NNS ties) (JJ mitogenic) (NN signal) (NN transduction))) (PP (TO to) (NP (NN cell) (NN cycle) (NN activation)))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_) (NN phosphatase)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ somatic) (JJ mammalian) (NNS cells))) (CC and) (PP (IN in) (NP (JJ meiotic) (NN frog) (NNS oocytes)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (SBAR (WHNP (WDT that)) (S (VP (NN contact) (NP (DT the) (NN MCP-1) (NN receptor) (, ,) (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN receptor) (NN binding) (NN site)) (PP (IN of) (NP (NN _PROT1_)))) (ADVP (RB also)) (VP (VBZ is) (ADJP (RB significantly) (JJ different) (PP (IN from) (NP (NP (DT the) (VBG binding) (NNS sites)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG providing) (NP (NP (NN insight)) (PP (IN into) (NP (NP (DT the) (NN issue)) (PP (IN of) (NP (NN receptor) (NN specificity))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN receptor) (NN binding) (NN site)) (PP (IN of) (NP (NN _PROT1_)))) (ADVP (RB also)) (VP (VBZ is) (ADJP (RB significantly) (JJ different) (PP (IN from) (NP (NP (DT the) (VBG binding) (NNS sites)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (S (VP (VBG providing) (NP (NP (NN insight)) (PP (IN into) (NP (NP (DT the) (NN issue)) (PP (IN of) (NP (NN receptor) (NN specificity))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN receptor) (NN binding) (NN site)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB also)) (VP (VBZ is) (ADJP (RB significantly) (JJ different) (PP (IN from) (NP (NP (DT the) (VBG binding) (NNS sites)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (S (VP (VBG providing) (NP (NP (NN insight)) (PP (IN into) (NP (NP (DT the) (NN issue)) (PP (IN of) (NP (NN receptor) (NN specificity))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBD was) (ADVP (RB previously)) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (NN N-terminus)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (VP (VB identify) (NP (NP (DT the) (NNS regions)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (SBAR (WHNP (WDT that)) (S (VP (NN contact) (NP (PRP$ its) (NN receptor)))))) (, ,) (NP (NN _PROT2_)))))))) (, ,) (S (NP (PRP we)) (VP (VBD substituted) (NP (NP (DT all) (JJ surface-exposed) (NNS residues)) (PP (IN with) (NP (NN alanine)))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ activates) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN apoptosis)) (PP (IN in) (NP (JJ human) (NN prostate) (NN cancer) (NN cell) (NNS lines))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN Tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN p85)))) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (CC both) (NP (NN LNCaP)) (CC and) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ promotes) (NP (NP (NN coprecipitation)) (PP (IN of) (NP (NN p85))) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT the) (JJ signal-transducing) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ promotes) (NP (NP (NN coprecipitation)) (PP (IN of) (NP (NN p85))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT the) (JJ signal-transducing) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VBZ promotes) (NP (NP (NN coprecipitation)) (PP (IN of) (NP (NN p85))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (JJ signal-transducing) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_AND_PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN SRrp130)))) (PP (IN in) (NP (NN corneal) (JJ epithelial) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN SRrp130)))) (PP (IN in) (NP (NN corneal) (JJ epithelial) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN SRrp130)))) (PP (IN in) (NP (NN corneal) (JJ epithelial) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN SRrp130)))) (PP (IN in) (NP (NN corneal) (JJ epithelial) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN SRrp130)))) (PP (IN in) (NP (NN corneal) (JJ epithelial) (NNS cells)))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN SRrp130)))) (PP (IN in) (NP (NN corneal) (JJ epithelial) (NNS cells)))))) |ET|
-1 |BT| (S1 (S (S (NP (CD Three) (JJ SR-rich) (NNS proteins)) (VP (VBD were) (VP (VBN identified) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (PP (IN with) (NP (NP (DT the) (NN C-terminus)) (PP (IN of) (NP (NNP Pnn))))))))))) (: :) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (JJ known) (NNS components)) (PP (IN of) (NP (NN spliceosome) (NN machinery)))) (, ,) (CC and) (NP (NP (DT a) (JJ novel) (JJ 130-kDa) (JJ nuclear) (NN protein)) (, ,) (NP (NN SRrp130)))))) |ET|
+1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT1_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT2_) (NN _PROT2_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT1_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT1_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT1_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT2_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT1_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT1_) (NN _PROT1_)))))))) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT1_) (NN _PROT1_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT1_) (NN _PROT1_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT2_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT1_) (NN _PROT1_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT2_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT2_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Subsequent) (NN amino) (NN acid) (NN sequencing)) (VP (VBD revealed) (NP (NP (JJ many) (NNS peptides)) (VP (VBG involving) (NP (NP (NP (NN _PROT_)) (VP (VBN cross-linked) (PP (CC either) (PP (TO to) (NP (PRP itself))) (CC or) (PP (TO to) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ other) (JJ known) (NN CE) (NN protein) (NNS components))) (, ,) (VP (VBG including) (NP (NN _PROT_) (NN _PROT_)))))))) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN keratins)) (, ,) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (JJ small) (JJ proline-rich) (NN superfamily)) (, ,) (NP (NN _PROT1_))))) (, ,) (CC and) (NP (NP (JJ unknown) (NNS proteins)) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN family))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Specific) (NNS glutamines)) (CC or) (NP (NNS lysines))) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD were) (VP (VBN used) (S (VP (TO to) (VP (VBP cross-link) (NP (NP (DT the) (JJ different) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NNS glutamines) (CD 495) (CC and) (CD 496)))) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (NN glutamine) (NN 288)) (PP (TO to) (NP (NN keratins)))) (, ,) (CC and) (NP (NP (NP (NNS lysines) (QP (CD 468) (, ,) (CD 485) (, ,) (CC and) (CD 508))) (CC and) (NP (NNS glutamines) (QP (CD 465) (CC and) (CD 489)))) (PP (IN for) (NP (NN interchain) (NN _PROT_) (NN cross-links))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Specific) (NNS glutamines)) (CC or) (NP (NNS lysines))) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD were) (VP (VBN used) (S (VP (TO to) (VP (VBP cross-link) (NP (NP (DT the) (JJ different) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NNS glutamines) (CD 495) (CC and) (CD 496)))) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN glutamine) (NN 288)) (PP (TO to) (NP (NN keratins)))) (, ,) (CC and) (NP (NP (NP (NNS lysines) (QP (CD 468) (, ,) (CD 485) (, ,) (CC and) (CD 508))) (CC and) (NP (NNS glutamines) (QP (CD 465) (CC and) (CD 489)))) (PP (IN for) (NP (NN interchain) (NN _PROT2_) (NN cross-links))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Specific) (NNS glutamines)) (CC or) (NP (NNS lysines))) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD were) (VP (VBN used) (S (VP (TO to) (VP (VBP cross-link) (NP (NP (DT the) (JJ different) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NNS glutamines) (CD 495) (CC and) (CD 496)))) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN glutamine) (NN 288)) (PP (TO to) (NP (NN keratins)))) (, ,) (CC and) (NP (NP (NP (NNS lysines) (QP (CD 468) (, ,) (CD 485) (, ,) (CC and) (CD 508))) (CC and) (NP (NNS glutamines) (QP (CD 465) (CC and) (CD 489)))) (PP (IN for) (NP (NN interchain) (NN _PROT2_) (NN cross-links))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN transmembrane) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN transmembrane) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN transmembrane) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT_)))) (, ,)) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB predominantly)) (PP (PP (IN in) (NP (JJ epithelial) (NNS cells))) (, ,) (PP (IN in) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NN tumor) (NN cell) (NNS lines))))) (, ,) (CC and) (PP (IN in) (NP (NNS lymphocytes)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT2_)))) (, ,)) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB predominantly)) (PP (PP (IN in) (NP (JJ epithelial) (NNS cells))) (, ,) (PP (IN in) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NN tumor) (NN cell) (NNS lines))))) (, ,) (CC and) (PP (IN in) (NP (NNS lymphocytes)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT2_)))) (, ,)) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB predominantly)) (PP (PP (IN in) (NP (JJ epithelial) (NNS cells))) (, ,) (PP (IN in) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NN tumor) (NN cell) (NNS lines))))) (, ,) (CC and) (PP (IN in) (NP (NNS lymphocytes)))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD interacted) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN catenin) (NN gene) (NN family))) (PP (VBG including) (NP (NP (NN _PROT2_)) (CC and) (NP (NN gamma-catenin))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))) (VP (VBZ is) (ADJP (JJ likely) (S (VP (TO to) (VP (VB be) (ADJP (JJ direct)))))) (, ,) (SBAR (IN as) (S (NP (DT the) (NN interaction)) (VP (VBZ occurs) (PP (IN in) (NP (NP (NN K562) (NNS cells)) (VP (VBG lacking) (NP (NP (JJ functional) (JJ adherens) (NNS junctions)) (CC and) (NP (NN _PROT2_) (NN expression)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Catalytic) (NNS domains)) (PP (IN of) (NP (DT the) (NN tyrosine) (NNS phosphatases) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN PTPbeta)))))) (VP (VBD did) (RB not) (VP (VB interact) (PP (IN with) (NP (NP (NNS proteins)) (PP (IN of) (NP (NP (DT the) (NN catenin) (NN family)) (PP (TO to) (NP (JJ detectable) (NNS levels)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (DT these) (NNS proteins)))) (VP (VBZ is) (VP (JJ specific)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Catalytic) (NNS domains)) (PP (IN of) (NP (DT the) (NN tyrosine) (NNS phosphatases) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN PTPbeta)))))) (VP (VBD did) (RB not) (VP (VB interact) (PP (IN with) (NP (NP (NNS proteins)) (PP (IN of) (NP (NP (DT the) (NN catenin) (NN family)) (PP (TO to) (NP (JJ detectable) (NNS levels)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (DT these) (NNS proteins)))) (VP (VBZ is) (VP (JJ specific)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Catalytic) (NNS domains)) (PP (IN of) (NP (DT the) (NN tyrosine) (NNS phosphatases) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN PTPbeta)))))) (VP (VBD did) (RB not) (VP (VB interact) (PP (IN with) (NP (NP (NNS proteins)) (PP (IN of) (NP (NP (DT the) (NN catenin) (NN family)) (PP (TO to) (NP (JJ detectable) (NNS levels)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (DT these) (NNS proteins)))) (VP (VBZ is) (VP (JJ specific)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_AND_PROT2_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBZ modulates) (NP (NP (NN co-operation)) (PP (IN between) (NP (NP (NP (JJ myocyte) (NN enhancer) (NN factor) (NN 2A)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN thyroid) (NN hormone) (JJ receptor-retinoid) (NN X) (NN receptor)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT2_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBZ modulates) (NP (NP (NN co-operation)) (PP (IN between) (NP (NP (NP (JJ myocyte) (NN enhancer) (NN factor) (NN 2A)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN thyroid) (NN hormone) (JJ receptor-retinoid) (NN X) (NN receptor)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBZ modulates) (NP (NP (NN co-operation)) (PP (IN between) (NP (NP (NP (JJ myocyte) (NN enhancer) (NN factor) (NN 2A)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN thyroid) (NN hormone) (JJ receptor-retinoid) (NN X) (NN receptor)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT2_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBZ modulates) (NP (NP (NN co-operation)) (PP (IN between) (NP (NP (NP (JJ myocyte) (NN enhancer) (NN factor) (NN 2A)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN thyroid) (NN hormone) (JJ receptor-retinoid) (NN X) (NN receptor)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBZ modulates) (NP (NP (NN co-operation)) (PP (IN between) (NP (NP (NP (JJ myocyte) (NN enhancer) (NN factor) (NN 2A)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN thyroid) (NN hormone) (JJ receptor-retinoid) (NN X) (NN receptor)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT1_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBZ modulates) (NP (NP (NN co-operation)) (PP (IN between) (NP (NP (NP (JJ myocyte) (NN enhancer) (NN factor) (NN 2A)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN thyroid) (NN hormone) (JJ receptor-retinoid) (NN X) (NN receptor)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_AND_PROT2_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBG interacting) (PP (IN with) (NP (NN transcription) (NNS factors))))) (VP (VBZ is) (ADJP (JJ able) (S (VP (TO to) (VP (VB increase) (NP (NP (PRP$ their) (NN activity)) (PP (IN on) (NP (NN target) (NN gene) (NNS promoters))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT2_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBG interacting) (PP (IN with) (NP (NN transcription) (NNS factors))))) (VP (VBZ is) (ADJP (JJ able) (S (VP (TO to) (VP (VB increase) (NP (NP (PRP$ their) (NN activity)) (PP (IN on) (NP (NN target) (NN gene) (NNS promoters))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (PRN (-LRB- -LRB-) (NP (`` ') (NN _PROT2_) ('' ')) (-RRB- -RRB-)) (JJ -binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN CBP)) (-RRB- -RRB-))) (VP (VBG interacting) (PP (IN with) (NP (NN transcription) (NNS factors))))) (VP (VBZ is) (ADJP (JJ able) (S (VP (TO to) (VP (VB increase) (NP (NP (PRP$ their) (NN activity)) (PP (IN on) (NP (NN target) (NN gene) (NNS promoters))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (DT the) (JJ same) (JJ C-terminal) (NN portion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ binds) (NP (NP (DT the) (JJ N-terminal) (NNS domains)) (PP (IN of) (NP (CC both) (NP (NN TR)) (CC and) (NP (NN _PROT2_))))))) (, ,) (CC and) (S (NP (PRP$ our) (ADJP (FW in) (FW vivo)) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN TR)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP form) (NP (DT a) (JJ ternary) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (DT the) (JJ same) (JJ C-terminal) (NN portion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ binds) (NP (NP (DT the) (JJ N-terminal) (NNS domains)) (PP (IN of) (NP (CC both) (NP (NN TR)) (CC and) (NP (NN _PROT_))))))) (, ,) (CC and) (S (NP (PRP$ our) (ADJP (FW in) (FW vivo)) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN TR)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP form) (NP (DT a) (JJ ternary) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (DT the) (JJ same) (JJ C-terminal) (NN portion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ binds) (NP (NP (DT the) (JJ N-terminal) (NNS domains)) (PP (IN of) (NP (CC both) (NP (NN TR)) (CC and) (NP (NN _PROT_))))))) (, ,) (CC and) (S (NP (PRP$ our) (ADJP (FW in) (FW vivo)) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN TR)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP form) (NP (DT a) (JJ ternary) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (DT the) (JJ same) (JJ C-terminal) (NN portion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ binds) (NP (NP (DT the) (JJ N-terminal) (NNS domains)) (PP (IN of) (NP (CC both) (NP (NN TR)) (CC and) (NP (NN _PROT1_))))))) (, ,) (CC and) (S (NP (PRP$ our) (ADJP (FW in) (FW vivo)) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN TR)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP form) (NP (DT a) (JJ ternary) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (DT the) (JJ same) (JJ C-terminal) (NN portion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ binds) (NP (NP (DT the) (JJ N-terminal) (NNS domains)) (PP (IN of) (NP (CC both) (NP (NN TR)) (CC and) (NP (NN _PROT1_))))))) (, ,) (CC and) (S (NP (PRP$ our) (ADJP (FW in) (FW vivo)) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN TR)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP form) (NP (DT a) (JJ ternary) (NN complex)))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (DT the) (JJ same) (JJ C-terminal) (NN portion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ binds) (NP (NP (DT the) (JJ N-terminal) (NNS domains)) (PP (IN of) (NP (CC both) (NP (NN TR)) (CC and) (NP (NN _PROT_))))))) (, ,) (CC and) (S (NP (PRP$ our) (ADJP (FW in) (FW vivo)) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN TR)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP form) (NP (DT a) (JJ ternary) (NN complex)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ human) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proteins)) (VP (VBP form) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN with) (NP (NN hMpp10))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB only)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN U3) (NN _PROT_)) (PP (IN in) (NP (NN 60-80S) (NN ribonucleoprotein) (NNS complexes)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ human) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS proteins)) (VP (VBP form) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN with) (NP (NN hMpp10))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB only)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN U3) (NN _PROT2_)) (PP (IN in) (NP (NN 60-80S) (NN ribonucleoprotein) (NNS complexes)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ human) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS proteins)) (VP (VBP form) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN with) (NP (NN hMpp10))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB only)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN U3) (NN _PROT2_)) (PP (IN in) (NP (NN 60-80S) (NN ribonucleoprotein) (NNS complexes)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (CC and) (NN mouse) (NNS homologs)) (PP (IN of) (NP (DT the) (NN yeast) (NN U3) (JJ snoRNP-associated) (NNS proteins) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN complementation) (NNS experiments)))) (VP (VBP show) (SBAR (IN that) (S (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NN mouse) (NN _PROT1_))) (, ,) (NP (NN mouse) (NN _PROT2_)) (VP (MD can) (ADVP (RB partially)) (VP (VB alleviate) (NP (NP (DT the) (NN growth) (NN defect)) (PP (IN of) (NP (DT the) (JJ corresponding) (NN yeast) (NN null) (NN strain)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN pre-rRNA) (NN processing)))) (VP (VBZ is) (ADVP (RB evolutionarily)) (VP (VBN conserved)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN complementation) (NNS experiments)))) (VP (VBP show) (SBAR (IN that) (S (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NN mouse) (NN _PROT1_))) (, ,) (NP (NN mouse) (NN _PROT_)) (VP (MD can) (ADVP (RB partially)) (VP (VB alleviate) (NP (NP (DT the) (NN growth) (NN defect)) (PP (IN of) (NP (DT the) (JJ corresponding) (NN yeast) (NN null) (NN strain)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NN pre-rRNA) (NN processing)))) (VP (VBZ is) (ADVP (RB evolutionarily)) (VP (VBN conserved)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN complementation) (NNS experiments)))) (VP (VBP show) (SBAR (IN that) (S (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NN mouse) (NN _PROT_))) (, ,) (NP (NN mouse) (NN _PROT1_)) (VP (MD can) (ADVP (RB partially)) (VP (VB alleviate) (NP (NP (DT the) (NN growth) (NN defect)) (PP (IN of) (NP (DT the) (JJ corresponding) (NN yeast) (NN null) (NN strain)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NN pre-rRNA) (NN processing)))) (VP (VBZ is) (ADVP (RB evolutionarily)) (VP (VBN conserved)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NP (NN density) (NN gradient) (NN centrifugation)) (NNS experiments)))) (VP (VBP show) (SBAR (IN that) (S (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NN hU3-55K))) (, ,) (NP (DT the) (JJ human) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proteins)) (ADVP (RB predominantly)) (VP (VBP interact) (PP (IN with) (NP (NP (DT the) (NN U3) (NN _PROT_)) (PP (IN in) (NP (NN 60-80S) (NN ribonucleoprotein) (NNS complexes))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NP (NN density) (NN gradient) (NN centrifugation)) (NNS experiments)))) (VP (VBP show) (SBAR (IN that) (S (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NN hU3-55K))) (, ,) (NP (DT the) (JJ human) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS proteins)) (ADVP (RB predominantly)) (VP (VBP interact) (PP (IN with) (NP (NP (DT the) (NN U3) (NN _PROT2_)) (PP (IN in) (NP (NN 60-80S) (NN ribonucleoprotein) (NNS complexes))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NP (NN density) (NN gradient) (NN centrifugation)) (NNS experiments)))) (VP (VBP show) (SBAR (IN that) (S (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NN hU3-55K))) (, ,) (NP (DT the) (JJ human) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS proteins)) (ADVP (RB predominantly)) (VP (VBP interact) (PP (IN with) (NP (NP (DT the) (NN U3) (NN _PROT2_)) (PP (IN in) (NP (NN 60-80S) (NN ribonucleoprotein) (NNS complexes))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Transient) (NN expression)) (PP (IN of) (NP (DT the) (JJ full-length) (NN _PROT1_))) (PP (IN without) (NP (NNS RSRS))) (PP (IN in) (NP (NN U1240MG) (NN glioblastoma) (NNS cells)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN promoter) (NN activity)))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ relative) (NN abundance)) (PP (IN of) (NP (NP (DT the) (CD two) (NN splice) (NNS variants)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN brain)))))) (VP (MD could) (VP (VB be) (NP (NP (DT an) (JJ important) (NN determinant)) (PP (IN for) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD tested) (NP (DT this) (NN point)) (PP (IN by) (S (VP (VBG cotransfecting) (NP (NN CHO) (NNS cells)) (PP (IN with) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN F) (NN beta) (NN alpha)) (CC and) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN subunit))) (CC or) (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_)) (NP (NN monomer))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD tested) (NP (DT this) (NN point)) (PP (IN by) (S (VP (VBG cotransfecting) (NP (NN CHO) (NNS cells)) (PP (IN with) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN F) (NN beta) (NN alpha)) (CC and) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN subunit))) (CC or) (NP (DT the) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)) (NP (NN monomer))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD tested) (NP (DT this) (NN point)) (PP (IN by) (S (VP (VBG cotransfecting) (NP (NN CHO) (NNS cells)) (PP (IN with) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN F) (NN beta) (NN alpha)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN subunit))) (CC or) (NP (DT the) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)) (NP (NN monomer))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN formation)) (PP (IN of) (NP (DT a) (JJ functional) (JJ single) (NN chain/subunit) (NN complex)))) (VP (VBD was) (RB not) (ADJP (JJ restricted) (PP (TO to) (NP (DT the) (NN FSH) (JJ single) (NN _PROT1_) (NN _PROT1_) (NN subunit)))) (SBAR (IN since) (S (NP (NN CG) (JJ single) (NN chain)) (VP (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ monomeric) (NN _PROT2_) (NN _PROT2_) (NN subunit)))) (CC and) (VP (VBZ exhibits) (NP (NN FSH) (NN activity))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This)) (VP (VBZ is) (ADJP (JJ relevant) (PP (IN for) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NP (NN LH)) (CC and) (NP (NN FSH))))))) (, ,) (SBAR (IN because) (S (S (NP (DT both)) (VP (VBP are) (VP (VBN synthesized) (PP (IN in) (NP (NP (DT the) (JJ same) (NN cell)) (-LRB- -LRB-) (PP (FW i.e.) (, ,) (NP (JJ pituitary) (NN gonadotrophs))) (-RRB- -RRB-)))))) (CC and) (S (NP (NP (JJ several)) (PP (IN of) (NP (NP (DT the) (NN alpha) (NN subunit) (NNS sequences)) (VP (VBN required) (PP (IN for) (NP (NP (NN association)) (PP (IN with) (NP (CC either) (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC or) (NP (NN _PROT2_) (NN _PROT2_))) (NNS subunits))))))))) (VP (VBP are) (JJ different)))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Previously)) (, ,) (NP (PRP we)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC or) (NP (NN _PROT2_) (NN _PROT2_))) (NN subunit) (NNS genes)) (VP (MD can) (VP (VB be) (VP (ADVP (RB genetically)) (VBN fused) (PP (TO to) (NP (DT the) (NN alpha) (NN gene))) (S (VP (TO to) (VP (VB produce) (NP (NP (ADJP (RB biologically) (JJ active)) (JJ single) (NNS chains)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN F) (NN beta) (NN alpha)))) (, ,) (ADVP (RB respectively))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Previously)) (, ,) (NP (PRP we)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC or) (NP (NN _PROT_) (NN _PROT_))) (NN subunit) (NNS genes)) (VP (MD can) (VP (VB be) (VP (ADVP (RB genetically)) (VBN fused) (PP (TO to) (NP (DT the) (NN alpha) (NN gene))) (S (VP (TO to) (VP (VB produce) (NP (NP (ADJP (RB biologically) (JJ active)) (JJ single) (NNS chains)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN F) (NN beta) (NN alpha)))) (, ,) (ADVP (RB respectively))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Previously)) (, ,) (NP (PRP we)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT1_) (NN _PROT1_))) (NN subunit) (NNS genes)) (VP (MD can) (VP (VB be) (VP (ADVP (RB genetically)) (VBN fused) (PP (TO to) (NP (DT the) (NN alpha) (NN gene))) (S (VP (TO to) (VP (VB produce) (NP (NP (ADJP (RB biologically) (JJ active)) (JJ single) (NNS chains)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN F) (NN beta) (NN alpha)))) (, ,) (ADVP (RB respectively))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (NN evidence)) (PP (IN of) (NP (NP (NN cross-talk)) (PP (IN between) (NP (NP (DT the) (JJ cannabinoid) (NN receptor) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (S (VP (VBG using) (NP (DT a) (JJ heterologous) (NN system))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (NN evidence)) (PP (IN of) (NP (NP (NN cross-talk)) (PP (IN between) (NP (NP (DT the) (JJ cannabinoid) (NN receptor) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (S (VP (VBG using) (NP (DT a) (JJ heterologous) (NN system))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (NN evidence)) (PP (IN of) (NP (NP (NN cross-talk)) (PP (IN between) (NP (NP (DT the) (JJ cannabinoid) (NN receptor) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (S (VP (VBG using) (NP (DT a) (JJ heterologous) (NN system))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NN contrast) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NP (DT the) (NN potency)) (PP (IN of) (NP (NP (JJ direct) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))))) (VP (VBD was) (RB not) (VP (VBN affected) (PP (IN by) (NP (NP (NN co-expression)) (PP (IN with) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NN contrast) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NP (DT the) (NN potency)) (PP (IN of) (NP (NP (JJ direct) (NN activation)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD was) (RB not) (VP (VBN affected) (PP (IN by) (NP (NP (NN co-expression)) (PP (IN with) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NN contrast) (TO to) (NP (NN _PROT_))) (, ,) (NP (NP (DT the) (NN potency)) (PP (IN of) (NP (NP (JJ direct) (NN activation)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD was) (RB not) (VP (VBN affected) (PP (IN by) (NP (NP (NN co-expression)) (PP (IN with) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN electron) (NN microscopy) (NNS experiments)) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (RB closely) (JJ apposed)) (PP (IN at) (NP (DT the) (NN plasma) (NN membrane) (NN level)))))))) (: ;) (S (NP (PRP they)) (VP (VBP are) (ADJP (JJ close) (S (ADVP (RB enough)) (VP (TO to) (VP (VB form) (NP (NNS hetero-oligomers)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN Rho) (NN family) (NN _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NN signaling) (NNS adapters) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN Rho) (NN family) (NN _PROT_) (NN _PROT_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NN signaling) (NNS adapters) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN Rho) (NN family) (NN _PROT_) (NN _PROT_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NN signaling) (NNS adapters) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN Rho) (NN family) (NN _PROT1_) (NN _PROT1_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NN signaling) (NNS adapters) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN Rho) (NN family) (NN _PROT1_) (NN _PROT1_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NN signaling) (NNS adapters) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN Rho) (NN family) (NN _PROT_) (NN _PROT_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NN signaling) (NNS adapters) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP are) (NP (NP (JJ scaffolding) (NNS proteins)) (VP (VBG acting) (ADVP (RB downstream) (PP (IN of) (NP (NN cell) (NN surface) (NNS receptors))))))) (CC and) (VP (VBP interact) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (JJ cytoplasmic) (NN signaling) (NNS proteins)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN Shc)) (, ,) (CC and) (NP (NN Crk)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (JJ several) (JJ classic) (JJ proline-rich) (NNS motifs)))) (, ,) (CC and) (S (NP (PRP it)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (JJ first) (NN SH3) (NN domain)) (PP (IN of) (NP (NP (NN Crk)) (CC and) (NP (JJ full-length) (NN _PROT2_)))))) (ADVP (FW in) (FW vitro))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cooperation)) (PP (IN with) (NP (JJ other) (NN adapter) (NNS molecules)))))) (VP (MD might) (VP (VB regulate) (NP (NP (DT the) (JJ cellular) (NN localization)) (PP (IN of) (NP (NN _PROT_))) (PP (IN under) (NP (JJ specific) (NNS stimuli)))))))) (, ,) (S (VP (VBG acting) (S (VP (TO to) (VP (VB regulate) (ADVP (RB precisely)) (NP (NP (NP (NN Rac)) (CC and) (NP (NN _PROT_))) (NNS activities)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cooperation)) (PP (IN with) (NP (JJ other) (NN adapter) (NNS molecules)))))) (VP (MD might) (VP (VB regulate) (NP (NP (DT the) (JJ cellular) (NN localization)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN under) (NP (JJ specific) (NNS stimuli)))))))) (, ,) (S (VP (VBG acting) (S (VP (TO to) (VP (VB regulate) (ADVP (RB precisely)) (NP (NP (NP (NN Rac)) (CC and) (NP (NN _PROT_))) (NNS activities)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cooperation)) (PP (IN with) (NP (JJ other) (NN adapter) (NNS molecules)))))) (VP (MD might) (VP (VB regulate) (NP (NP (DT the) (JJ cellular) (NN localization)) (PP (IN of) (NP (NN _PROT_))) (PP (IN under) (NP (JJ specific) (NNS stimuli)))))))) (, ,) (S (VP (VBG acting) (S (VP (TO to) (VP (VB regulate) (ADVP (RB precisely)) (NP (NP (NP (NN Rac)) (CC and) (NP (NN _PROT2_))) (NNS activities)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN cooperation)) (PP (IN with) (NP (JJ other) (NN adapter) (NNS molecules)))))) (VP (MD might) (VP (VB regulate) (NP (NP (DT the) (JJ cellular) (NN localization)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN under) (NP (JJ specific) (NNS stimuli)))))))) (, ,) (S (VP (VBG acting) (S (VP (TO to) (VP (VB regulate) (ADVP (RB precisely)) (NP (NP (NP (NN Rac)) (CC and) (NP (NN _PROT_))) (NNS activities)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN cooperation)) (PP (IN with) (NP (JJ other) (NN adapter) (NNS molecules)))))) (VP (MD might) (VP (VB regulate) (NP (NP (DT the) (JJ cellular) (NN localization)) (PP (IN of) (NP (NN _PROT_))) (PP (IN under) (NP (JJ specific) (NNS stimuli)))))))) (, ,) (S (VP (VBG acting) (S (VP (TO to) (VP (VB regulate) (ADVP (RB precisely)) (NP (NP (NP (NN Rac)) (CC and) (NP (NN _PROT2_))) (NNS activities)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cooperation)) (PP (IN with) (NP (JJ other) (NN adapter) (NNS molecules)))))) (VP (MD might) (VP (VB regulate) (NP (NP (DT the) (JJ cellular) (NN localization)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN under) (NP (JJ specific) (NNS stimuli)))))))) (, ,) (S (VP (VBG acting) (S (VP (TO to) (VP (VB regulate) (ADVP (RB precisely)) (NP (NP (NP (NN Rac)) (CC and) (NP (NN _PROT2_))) (NNS activities)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBD led) (PP (TO to) (NP (NP (NN identification)) (PP (IN of) (NP (NP (NP (DT a) (JJ novel) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN for) (NP (NN Rho) (NN family) (NNS GTPases)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN GAP) (NN domain)) (VP (VP (VBZ shows) (NP (NP (JJ high) (NN similarity)) (PP (TO to) (NP (DT the) (ADJP (RB recently) (VBN cloned)) (NN _PROT1_))))) (CC and) (VP (VBZ displays) (NP (NP (NN activity)) (PP (IN toward) (NP (NP (NN RhoA)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (ADVP (FW in) (FW vitro)))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN GAP) (NN domain)) (VP (VP (VBZ shows) (NP (NP (JJ high) (NN similarity)) (PP (TO to) (NP (DT the) (ADJP (RB recently) (VBN cloned)) (NN _PROT1_))))) (CC and) (VP (VBZ displays) (NP (NP (NN activity)) (PP (IN toward) (NP (NP (NN RhoA)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (ADVP (FW in) (FW vitro)))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN GAP) (NN domain)) (VP (VP (VBZ shows) (NP (NP (JJ high) (NN similarity)) (PP (TO to) (NP (DT the) (ADJP (RB recently) (VBN cloned)) (NN _PROT_))))) (CC and) (VP (VBZ displays) (NP (NP (NN activity)) (PP (IN toward) (NP (NP (NN RhoA)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (ADVP (FW in) (FW vitro)))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN protein)) (VP (VBD was) (VP (VBN named) (NP (NN _PROT1_)) (PP (IN for) (NP (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_) (NNS proteins))))))) (CC and) (NP (NP (PRP$ its) (NN activity)) (PP (IN toward) (NP (NP (NN Rac)) (CC and) (NP (NN _PROT_))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN protein)) (VP (VBD was) (VP (VBN named) (NP (NN _PROT1_)) (PP (IN for) (NP (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT_) (NNS proteins))))))) (CC and) (NP (NP (PRP$ its) (NN activity)) (PP (IN toward) (NP (NP (NN Rac)) (CC and) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN protein)) (VP (VBD was) (VP (VBN named) (NP (NN _PROT_)) (PP (IN for) (NP (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT1_) (NNS proteins))))))) (CC and) (NP (NP (PRP$ its) (NN activity)) (PP (IN toward) (NP (NP (NN Rac)) (CC and) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN 293T) (NNS cells)))) (VP (VBD led) (PP (TO to) (NP (NP (NP (DT a) (NN reduction)) (PP (IN in) (NP (JJ active) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS levels)))) (CONJP (CC but) (RB not)) (NP (NN RhoA))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN 293T) (NNS cells)))) (VP (VBD led) (PP (TO to) (NP (NP (NP (DT a) (NN reduction)) (PP (IN in) (NP (JJ active) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS levels)))) (CONJP (CC but) (RB not)) (NP (NN RhoA))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN 293T) (NNS cells)))) (VP (VBD led) (PP (TO to) (NP (NP (NP (DT a) (NN reduction)) (PP (IN in) (NP (JJ active) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS levels)))) (CONJP (CC but) (RB not)) (NP (NN RhoA))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Specific) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN c/EBPbeta))))) (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ transcriptional) (NN activation)) (PP (IN of) (NP (DT the) (JJ human) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN _PROT2_) (NN gene)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT The) (JJ sterol-independent) (JJ regulatory) (NN element)) (PRN (-LRB- -LRB-) (NP (VB SIRE)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN promoter)))) (VP (VBZ mediates) (NP (NP (ADJP (NP (NN _PROT_) (NN _PROT_)) (-LRB- -LRB-) (NN OM) (-RRB- -RRB-) (JJ -induced)) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene)))) (PP (IN through) (NP (DT a) (JJ cholesterol-independent) (NN pathway)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT The) (JJ sterol-independent) (JJ regulatory) (NN element)) (PRN (-LRB- -LRB-) (NP (VB SIRE)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN promoter)))) (VP (VBZ mediates) (NP (NP (ADJP (NP (NN _PROT2_) (NN _PROT2_)) (-LRB- -LRB-) (NN OM) (-RRB- -RRB-) (JJ -induced)) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene)))) (PP (IN through) (NP (DT a) (JJ cholesterol-independent) (NN pathway)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT The) (JJ sterol-independent) (JJ regulatory) (NN element)) (PRN (-LRB- -LRB-) (NP (VB SIRE)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN promoter)))) (VP (VBZ mediates) (NP (NP (ADJP (NP (NN _PROT_) (NN _PROT_)) (-LRB- -LRB-) (NN OM) (-RRB- -RRB-) (JJ -induced)) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene)))) (PP (IN through) (NP (DT a) (JJ cholesterol-independent) (NN pathway)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT The) (JJ sterol-independent) (JJ regulatory) (NN element)) (PRN (-LRB- -LRB-) (NP (VB SIRE)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN promoter)))) (VP (VBZ mediates) (NP (NP (ADJP (NP (NN _PROT2_) (NN _PROT2_)) (-LRB- -LRB-) (NN OM) (-RRB- -RRB-) (JJ -induced)) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene)))) (PP (IN through) (NP (DT a) (JJ cholesterol-independent) (NN pathway)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT The) (JJ sterol-independent) (JJ regulatory) (NN element)) (PRN (-LRB- -LRB-) (NP (VB SIRE)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN promoter)))) (VP (VBZ mediates) (NP (NP (ADJP (NP (NN _PROT_) (NN _PROT_)) (-LRB- -LRB-) (NN OM) (-RRB- -RRB-) (JJ -induced)) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene)))) (PP (IN through) (NP (DT a) (JJ cholesterol-independent) (NN pathway)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT The) (JJ sterol-independent) (JJ regulatory) (NN element)) (PRN (-LRB- -LRB-) (NP (VB SIRE)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN promoter)))) (VP (VBZ mediates) (NP (NP (ADJP (NP (NN _PROT1_) (NN _PROT1_)) (-LRB- -LRB-) (NN OM) (-RRB- -RRB-) (JJ -induced)) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene)))) (PP (IN through) (NP (DT a) (JJ cholesterol-independent) (NN pathway)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Regulation)) (PP (IN of) (NP (NN neutrophil) (NN adhesion))) (PP (IN by) (NP (JJ pituitary) (NN growth) (NN hormone)))) (VP (VBZ accompanies) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN p125FAK)) (, ,) (CC and) (NP (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (JJ pituitary) (NN GH)) (VP (VBZ modulates) (NP (NN neutrophil) (NN adhesion)) (PP (IN through) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN p125FAK)) (, ,) (CC and) (NP (NN _PROT2_)) (CC and) (NP (NN actin) (NN polymerization)))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Pituitary) (NN GH)) (VP (VBD triggered) (NP (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (CC and) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NNS neutrophils)))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Pituitary) (NN GH)) (VP (VBD triggered) (NP (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (CC and) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NNS neutrophils)))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Pituitary) (NN GH)) (VP (VBD triggered) (NP (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (CC and) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NNS neutrophils)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Preincubation)) (PP (IN with) (NP (NP (NN genistein)) (, ,) (NP (DT a) (NN tyrosine) (NN kinase) (NN inhibitor)) (, ,)))) (VP (VBD blocked) (NP (NP (DT the) (JJ GH-stimulated) (NN adhesion)) (CC and) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN p125FAK)) (, ,) (CC and) (NP (NN _PROT_) (NN phosphorylation))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Preincubation)) (PP (IN with) (NP (NP (NN genistein)) (, ,) (NP (DT a) (NN tyrosine) (NN kinase) (NN inhibitor)) (, ,)))) (VP (VBD blocked) (NP (NP (DT the) (JJ GH-stimulated) (NN adhesion)) (CC and) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN p125FAK)) (, ,) (CC and) (NP (NN _PROT2_) (NN phosphorylation))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Preincubation)) (PP (IN with) (NP (NP (NN genistein)) (, ,) (NP (DT a) (NN tyrosine) (NN kinase) (NN inhibitor)) (, ,)))) (VP (VBD blocked) (NP (NP (DT the) (JJ GH-stimulated) (NN adhesion)) (CC and) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN p125FAK)) (, ,) (CC and) (NP (NN _PROT2_) (NN phosphorylation))))))) |ET|
+1 |BT| (S1 (S (NP (NN Immunoprecipitation) (NNS experiments)) (VP (VBD revealed) (NP (NP (DT a) (JJ physical) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN p125FAK)))) (PP (IN via) (NP (NN _PROT2_))) (ADVP (FW in) (FW vivo))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Cutting) (NN edge)) (: :) (NP (NP (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN T) (NN cell) (NN counterreceptor)) (PP (IN for) (NP (DT the) (NN macrophage) (NN adhesion) (NN receptor) (NN _PROT2_))))))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Cutting) (NN edge)) (: :) (NP (NP (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN T) (NN cell) (NN counterreceptor)) (PP (IN for) (NP (DT the) (NN macrophage) (NN adhesion) (NN receptor) (NN _PROT_))))))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Cutting) (NN edge)) (: :) (NP (NP (NP (NN _PROT_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN T) (NN cell) (NN counterreceptor)) (PP (IN for) (NP (DT the) (NN macrophage) (NN adhesion) (NN receptor) (NN _PROT1_))))))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN 130-)) (CC and) (NP (JJ 240-kDa) (NN sialoadhesin-binding) (NNS glycoproteins))) (VP (VBD were) (VP (VBN identified) (PP (IN as) (NP (DT the) (NNS sialomucins) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN 130-)) (CC and) (NP (JJ 240-kDa) (NN sialoadhesin-binding) (NNS glycoproteins))) (VP (VBD were) (VP (VBN identified) (PP (IN as) (NP (DT the) (NNS sialomucins) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN 130-)) (CC and) (NP (JJ 240-kDa) (NN sialoadhesin-binding) (NNS glycoproteins))) (VP (VBD were) (VP (VBN identified) (PP (IN as) (NP (DT the) (NNS sialomucins) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells))))) (VP (VBD supported) (NP (NP (VBN increased) (NN binding)) (PP (TO to) (NP (JJ immobilized) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (NN _PROT1_)) (VP (VBD bound) (NP (NP (JJ different) (NNS glycoforms)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells)) (, ,) (PP (VBG including) (NP (NP (ADJP (ADJP (JJ unbranched)) (PRN (-LRB- -LRB-) (NP (NN core) (CD 1)) (-RRB- -RRB-)) (CC and) (ADJP (JJ branched)) (PRN (-LRB- -LRB-) (NP (NN core) (CD 2)) (-RRB- -RRB-))) (NN O) (: :) (JJ -linked) (NNS glycans)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADVP (RB normally)) (VP (VBN found) (PP (IN on) (NP (NP (NN _PROT_)) (PP (IN in) (NP (ADJP (ADJP (VBG resting)) (CC and) (ADJP (VBN activated))) (NN T) (NNS cells))))))))))))))))) (, ,) (ADVP (RB respectively))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (NN _PROT1_)) (VP (VBD bound) (NP (NP (JJ different) (NNS glycoforms)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells)) (, ,) (PP (VBG including) (NP (NP (ADJP (ADJP (JJ unbranched)) (PRN (-LRB- -LRB-) (NP (NN core) (CD 1)) (-RRB- -RRB-)) (CC and) (ADJP (JJ branched)) (PRN (-LRB- -LRB-) (NP (NN core) (CD 2)) (-RRB- -RRB-))) (NN O) (: :) (JJ -linked) (NNS glycans)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADVP (RB normally)) (VP (VBN found) (PP (IN on) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (ADJP (ADJP (VBG resting)) (CC and) (ADJP (VBN activated))) (NN T) (NNS cells))))))))))))))))) (, ,) (ADVP (RB respectively))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (NN _PROT_)) (VP (VBD bound) (NP (NP (JJ different) (NNS glycoforms)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells)) (, ,) (PP (VBG including) (NP (NP (ADJP (ADJP (JJ unbranched)) (PRN (-LRB- -LRB-) (NP (NN core) (CD 1)) (-RRB- -RRB-)) (CC and) (ADJP (JJ branched)) (PRN (-LRB- -LRB-) (NP (NN core) (CD 2)) (-RRB- -RRB-))) (NN O) (: :) (JJ -linked) (NNS glycans)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADVP (RB normally)) (VP (VBN found) (PP (IN on) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (ADJP (ADJP (VBG resting)) (CC and) (ADJP (VBN activated))) (NN T) (NNS cells))))))))))))))))) (, ,) (ADVP (RB respectively))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP identify) (NP (NN _PROT1_)) (PP (IN as) (NP (NP (DT a) (NN T) (NN cell) (NN counterreceptor)) (PP (IN for) (NP (NN _PROT2_)))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (PP (IN in) (NN addition) (TO to) (NP (PRP$ its) (JJ anti-adhesive) (NN role))) (NP (NN _PROT_)) (VP (MD may) (VP (VB promote) (NP (JJ cell-cell) (NNS interactions)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP identify) (NP (NN _PROT1_)) (PP (IN as) (NP (NP (DT a) (NN T) (NN cell) (NN counterreceptor)) (PP (IN for) (NP (NN _PROT_)))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (PP (IN in) (NN addition) (TO to) (NP (PRP$ its) (JJ anti-adhesive) (NN role))) (NP (NN _PROT2_)) (VP (MD may) (VP (VB promote) (NP (JJ cell-cell) (NNS interactions)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP identify) (NP (NN _PROT_)) (PP (IN as) (NP (NP (DT a) (NN T) (NN cell) (NN counterreceptor)) (PP (IN for) (NP (NN _PROT1_)))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (PP (IN in) (NN addition) (TO to) (NP (PRP$ its) (JJ anti-adhesive) (NN role))) (NP (NN _PROT2_)) (VP (MD may) (VP (VB promote) (NP (JJ cell-cell) (NNS interactions)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN role)) (PP (IN for) (NP (NP (NN _PROT1_) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN cytokinesis)))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT2_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT2_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ phosphorylates) (NP (NN _PROT2_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT1_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT1_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VP (VBP characterize) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ phosphorylates) (NP (NN _PROT_)) (PP (IN at) (NP (VBN conserved) (NP (NP (NN S274)) (CC and) (NP (NN S326))) (NNS residues))) (ADVP (FW in) (FW vitro)))))) (, ,) (CC and) (VP (VBP present) (NP (NN evidence) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN RNA) (NN interference)))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ multiple) (JJ mitotic) (NNS defects)) (, ,) (PP (VBG including) (NP (NP (NN multinucleation)) (CC and) (NP (NP (NNS cells)) (VP (VBN arrested) (PP (IN at) (NP (DT the) (NN midbody) (NN stage))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (VP (VBN rescued) (PP (PP (IN by) (NP (NP (JJ ectopic) (NN expression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT2_))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN phosphorylation) (NNS sites))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN RNA) (NN interference)))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ multiple) (JJ mitotic) (NNS defects)) (, ,) (PP (VBG including) (NP (NP (NN multinucleation)) (CC and) (NP (NP (NNS cells)) (VP (VBN arrested) (PP (IN at) (NP (DT the) (NN midbody) (NN stage))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (VP (VBN rescued) (PP (PP (IN by) (NP (NP (JJ ectopic) (NN expression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT_))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN phosphorylation) (NNS sites))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN RNA) (NN interference)))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ multiple) (JJ mitotic) (NNS defects)) (, ,) (PP (VBG including) (NP (NP (NN multinucleation)) (CC and) (NP (NP (NNS cells)) (VP (VBN arrested) (PP (IN at) (NP (DT the) (NN midbody) (NN stage))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (VP (VBN rescued) (PP (PP (IN by) (NP (NP (JJ ectopic) (NN expression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT_))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN phosphorylation) (NNS sites))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN RNA) (NN interference)))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ multiple) (JJ mitotic) (NNS defects)) (, ,) (PP (VBG including) (NP (NP (NN multinucleation)) (CC and) (NP (NP (NNS cells)) (VP (VBN arrested) (PP (IN at) (NP (DT the) (NN midbody) (NN stage))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (VP (VBN rescued) (PP (PP (IN by) (NP (NP (JJ ectopic) (NN expression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT1_))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN phosphorylation) (NNS sites))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN RNA) (NN interference)))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ multiple) (JJ mitotic) (NNS defects)) (, ,) (PP (VBG including) (NP (NP (NN multinucleation)) (CC and) (NP (NP (NNS cells)) (VP (VBN arrested) (PP (IN at) (NP (DT the) (NN midbody) (NN stage))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (VP (VBN rescued) (PP (PP (IN by) (NP (NP (JJ ectopic) (NN expression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT1_))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN phosphorylation) (NNS sites))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN RNA) (NN interference)))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ multiple) (JJ mitotic) (NNS defects)) (, ,) (PP (VBG including) (NP (NP (NN multinucleation)) (CC and) (NP (NP (NNS cells)) (VP (VBN arrested) (PP (IN at) (NP (DT the) (NN midbody) (NN stage))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (VP (VBN rescued) (PP (PP (IN by) (NP (NP (JJ ectopic) (NN expression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT_))))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT1_)) (PP (IN with) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN phosphorylation) (NNS sites))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (VP (MD may) (VP (VB influence) (NP (NN cytokinesis))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ prominent) (NN isolate)) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_AND_PROT2_)))) (, ,)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (PP (CONJP (RB not) (RB only)) (PP (IN in) (NP (FW vivo))) (CONJP (CC but) (RB also))))) (ADVP (FW in) (FW vitro))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ prominent) (NN isolate)) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (PP (CONJP (RB not) (RB only)) (PP (IN in) (NP (FW vivo))) (CONJP (CC but) (RB also))))) (ADVP (FW in) (FW vitro))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ prominent) (NN isolate)) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (PP (CONJP (RB not) (RB only)) (PP (IN in) (NP (FW vivo))) (CONJP (CC but) (RB also))))) (ADVP (FW in) (FW vitro))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN with) (NP (NP (DT a) (JJ characteristic) (NN distribution)) (PP (IN in) (NP (JJ large) (ADJP (RB irregularly) (VBN shaped)) (JJ nuclear) (NNS speckles))))))) (CC and) (VP (VBZ co-localizes) (ADVP (RB perfectly)) (PP (IN with) (NP (DT the) (JJ SR) (JJ domain-containing) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (S (VP (VBG Using) (NP (NN Cox) (NN univariate) (NN analysis)))) (, ,) (NP (PRP we)) (VP (VBD determined) (SBAR (SBAR (IN that) (S (NP (NP (JJ angiolymphatic) (NN tumor) (NNS emboli)) (CC and) (NP (JJ non-well-differentiated) (NN tumor) (NNS cells))) (VP (VBD were) (NP (NP (CD two) (JJ significant) (JJ conventional) (JJ pathologic) (NNS predictors)) (PP (IN of) (NP (NN tumor) (NN recurrence))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB also)) (NP (JJ significant) (NNS predictors)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ Several) (NNS genes)) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN process)))))) (, ,) (CC and) (S (NP (CD two)) (VP (VBP have) (VP (VBN been) (NP (NP (DT the) (NN focus)) (PP (IN of) (NP (JJ recent) (NN interest)))))))) (: :) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN gene)) (CC and) (NP (NP (DT the) (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ Several) (NNS genes)) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN process)))))) (, ,) (CC and) (S (NP (CD two)) (VP (VBP have) (VP (VBN been) (NP (NP (DT the) (NN focus)) (PP (IN of) (NP (JJ recent) (NN interest)))))))) (: :) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN gene)) (CC and) (NP (NP (DT the) (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ Several) (NNS genes)) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN process)))))) (, ,) (CC and) (S (NP (CD two)) (VP (VBP have) (VP (VBN been) (NP (NP (DT the) (NN focus)) (PP (IN of) (NP (JJ recent) (NN interest)))))))) (: :) (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN gene)) (CC and) (NP (NP (DT the) (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene)) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 1q23))) (, ,) (PP (IN near) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN TNF) (NN homolog) (NN _PROT2_) (NN _PROT_) (NN [5)))))) (-RRB- -RSB-)) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene)) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 1q23))) (, ,) (PP (IN near) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN TNF) (NN homolog) (NN _PROT2_) (NN _PROT2_) (NN [5)))))) (-RRB- -RSB-)) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene)) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 1q23))) (, ,) (PP (IN near) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN TNF) (NN homolog) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN [5)))))) (-RRB- -RSB-)) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD found) (NP (NN _PROT1_) (NN mRNA)) (PP (IN in) (NP (JJ several) (JJ peripheral) (NNS tissues)))) (, ,) (CC and) (VP (VBD detected) (NP (NN _PROT2_) (NN protein)) (PP (IN on) (NP (VBN cultured) (JJ vascular) (JJ endothelial) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS levels)) (PP (IN of) (NP (NN _PROT1_) (NN mRNA))) (PP (IN in) (NP (NNS tissues)))) (VP (VBD were) (ADJP (RB generally) (JJ low)))) (: ;) (S (PP (IN in) (NP (JJ peripheral) (NN blood) (NN T) (NNS cells))) (, ,) (ADVP (RB however)) (, ,) (NP (NN antigen-receptor) (NN stimulation)) (VP (VBD led) (PP (TO to) (NP (NP (DT a) (JJ substantial) (NN induction)) (PP (IN of) (NP (NN _PROT2_) (NNS transcripts))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT2_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT2_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN Jurkat) (NN T) (NN leukemia) (NNS cells)))) (VP (VBD inhibited) (NP (JJ antigen-receptor-induced) (NN cell) (NN death)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB modulate) (NP (NN T) (NN lymphocyte) (NN survival)) (PP (IN in) (NP (JJ peripheral) (NNS tissues)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (ADJP (RB newly) (VBN identified)) (NN member)) (PP (IN of) (NP (NP (NN tumor) (NN necrosis) (NN factor) (NN receptor) (NN superfamily)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ suppresses) (NP (JJ _PROT2_) (NN apoptosis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD inhibited) (NP (NP (JJ _PROT2_) (NN cytotoxicity)) (PP (IN in) (NP (NN HT29) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_AND_PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS mutations)) (VP (VBP account) (PP (IN for) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ early-onset) (JJ dominant) (NNS cases)) (PP (IN of) (NP (JJ familial) (NN Alzheimer) (POS 's) (NN disease))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NP (NP (JJ human) (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (JJ hydrophilic) (NN loop)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (JJ small) (NN GTPase)) (VP (VBG belonging) (PP (TO to) (NP (DT the) (JJ Ras-related) (NN superfamily)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NP (NP (JJ human) (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (JJ hydrophilic) (NN loop)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (DT a) (JJ small) (NN GTPase)) (VP (VBG belonging) (PP (TO to) (NP (DT the) (JJ Ras-related) (NN superfamily)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NP (NP (JJ human) (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (JJ hydrophilic) (NN loop)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (DT a) (JJ small) (NN GTPase)) (VP (VBG belonging) (PP (TO to) (NP (DT the) (JJ Ras-related) (NN superfamily)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Interaction) (NNS domains)) (VP (VBD were) (VP (VBN mapped) (PP (PP (TO to) (NP (NP (NNS codons) (CD 374-400)) (PP (IN for) (NP (NN _PROT1_))))) (CC and) (PP (TO to) (NP (NP (NNS codons) (CD 106-179)) (PP (IN for) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN region)) (VP (VBG including) (NP (DT the) (JJ fourth) (JJ GTP-binding) (NN domain)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (VP (VBD was) (VP (VBN derived) (PP (IN by) (S (VP (VP (VBG linking) (NP (NP (DT the) (CD two) (NN peptide) (NNS chains)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN dimer)))) (PP (IN by) (NP (DT a) (JJ seven-residue) (NN linker)))) (CC and) (VP (VBG changing) (NP (NP (NN His111)) (PP (IN in) (NP (DT the) (JJ first) (NN chain)))) (PP (TO to) (NP (DT an) (JJ aspartic) (NN acid) (NN residue)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT_)) (VP (VBD was) (VP (VBN derived) (PP (IN by) (S (VP (VP (VBG linking) (NP (NP (DT the) (CD two) (NN peptide) (NNS chains)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN dimer)))) (PP (IN by) (NP (DT a) (JJ seven-residue) (NN linker)))) (CC and) (VP (VBG changing) (NP (NP (NN His111)) (PP (IN in) (NP (DT the) (JJ first) (NN chain)))) (PP (TO to) (NP (DT an) (JJ aspartic) (NN acid) (NN residue)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (VP (VBN derived) (PP (IN by) (S (VP (VP (VBG linking) (NP (NP (DT the) (CD two) (NN peptide) (NNS chains)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN dimer)))) (PP (IN by) (NP (DT a) (JJ seven-residue) (NN linker)))) (CC and) (VP (VBG changing) (NP (NP (NN His111)) (PP (IN in) (NP (DT the) (JJ first) (NN chain)))) (PP (TO to) (NP (DT an) (JJ aspartic) (NN acid) (NN residue)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (NP (CD 2.9) (DT A) (NN resolution)) (PP (IN from) (NP (NP (NNS crystals)) (VP (VBN grown) (PP (IN in) (NP (ADJP (CD 1.4) (NN M)) (NN citrate) (NNS solutions))) (PP (IN at) (NP (NN pH) (CD 7.6)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (DT the) (JJ wild-type) (JJ receptor-binding) (NN domain)) (CC and) (NP (NP (DT the) (JJ Asp111-containing) (NN domain)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))) (VP (VBP show) (SBAR (IN that) (S (NP (PRP they)) (VP (VP (VBP are) (ADJP (RB structurally) (JJ equivalent))) (CC but) (VP (VBP have) (NP (ADJP (RB very) (JJ different)) (JJ electrostatic) (NN surface) (NNS potentials)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN binding)) (VP (VBZ does) (RB not) (VP (VB result) (PP (IN in) (NP (NP (DT a) (JJ large) (JJ conformational) (NN change)) (PP (IN in) (NP (DT the) (NN AB) (NN loop))))) (SBAR (IN as) (S (ADVP (RB previously)) (VP (VBN suggested))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (ADVP (RB also)) (VP (VBZ reveals) (NP (NP (DT the) (JJ final) (CD six) (JJ C-terminal) (NN amino) (NN acid) (NNS residues)) (PP (IN of) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 253-258))) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN observed) (PP (IN in) (NP (DT any) (JJ other) (VBN reported) (NN _PROT_) (NNS structures))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (ADVP (RB also)) (VP (VBZ reveals) (NP (NP (DT the) (JJ final) (CD six) (JJ C-terminal) (NN amino) (NN acid) (NNS residues)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 253-258))) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN observed) (PP (IN in) (NP (DT any) (JJ other) (VBN reported) (NN _PROT2_) (NNS structures))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (ADVP (RB also)) (VP (VBZ reveals) (NP (NP (DT the) (JJ final) (CD six) (JJ C-terminal) (NN amino) (NN acid) (NNS residues)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 253-258))) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN observed) (PP (IN in) (NP (DT any) (JJ other) (VBN reported) (NN _PROT2_) (NNS structures))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Despite) (NP (NP (NN binding)) (PP (TO to) (NP (QP (RB only) (CD one)) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_))))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (ADJP (RB biologically) (JJ active) (PP (IN in) (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NP (NN MHC) (NN class) (CD I)) (NN induction)) (, ,) (CC and) (NP (JJ anti-viral) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Despite) (NP (NP (NN binding)) (PP (TO to) (NP (QP (RB only) (CD one)) (NN _PROT1_) (NN _PROT_) (NN _PROT_))))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (VP (VBZ is) (ADJP (RB biologically) (JJ active) (PP (IN in) (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NP (NN MHC) (NN class) (CD I)) (NN induction)) (, ,) (CC and) (NP (JJ anti-viral) (NNS assays))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Despite) (NP (NP (NN binding)) (PP (TO to) (NP (QP (RB only) (CD one)) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (VP (VBZ is) (ADJP (RB biologically) (JJ active) (PP (IN in) (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NP (NN MHC) (NN class) (CD I)) (NN induction)) (, ,) (CC and) (NP (JJ anti-viral) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ current) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (S (NP (NP (DT the) (JJ main) (NN role)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN dimer)))) (VP (VBG being) (S (VP (TO to) (VP (VB decrease) (NP (NP (DT the) (NN dissociation) (NN constant)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN for) (NP (PRP$ its) (JJ cellular) (NNS receptors))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Human) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ new) (NN cyclin)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (CD two) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene) (NN family))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD showed) (NP (NP (JJ genetic) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN gene)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD functioned) (PP (IN at) (NP (NN START))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (DT the) (NN _PROT_) (NN protein))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD showed) (NP (NP (JJ genetic) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN gene)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD functioned) (PP (IN at) (NP (NN START))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN protein))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBD showed) (NP (NP (JJ genetic) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN gene)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD functioned) (PP (IN at) (NP (NN START))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN protein))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD Two) (JJ human) (NNS genes)) (VP (VBD were) (VP (VBN identified) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB interact) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (S (VP (TO to) (VP (VB perform) (NP (NN START)) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG containing) (NP (DT a) (NN _PROT2_) (NN mutation))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN One)) (VP (VBD was) (NP (NN _PROT1_AND_PROT2_)))) (, ,) (CC and) (S (NP (DT the) (JJ second)) (VP (VBD was) (NP (NP (DT the) (JJ human) (NN homolog)) (PP (IN of) (NP (NN Xenopus) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN One)) (VP (VBD was) (NP (NN _PROT1_)))) (, ,) (CC and) (S (NP (DT the) (JJ second)) (VP (VBD was) (NP (NP (DT the) (JJ human) (NN homolog)) (PP (IN of) (NP (NN Xenopus) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN One)) (VP (VBD was) (NP (NN _PROT1_)))) (, ,) (CC and) (S (NP (DT the) (JJ second)) (VP (VBD was) (NP (NP (DT the) (JJ human) (NN homolog)) (PP (IN of) (NP (NN Xenopus) (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBN produced) (PP (IN in) (NP (FW E.) (FW coli))))) (VP (VP (VBD bound)) (CC and) (VP (VBD activated) (NP (DT the) (NN _PROT2_) (NN protein)) (PP (IN in) (NP (NP (NNS extracts)) (PP (IN from) (NP (JJ human) (NN G1) (NNS cells)))))))) (, ,) (CC and) (S (NP (NP (NNS antibodies)) (PP (IN against) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD immunoprecipitated) (NP (NP (DT a) (NN histone) (NN H1) (NN kinase)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBN produced) (PP (IN in) (NP (FW E.) (FW coli))))) (VP (VP (VBD bound)) (CC and) (VP (VBD activated) (NP (DT the) (NN _PROT_) (NN protein)) (PP (IN in) (NP (NP (NNS extracts)) (PP (IN from) (NP (JJ human) (NN G1) (NNS cells)))))))) (, ,) (CC and) (S (NP (NP (NNS antibodies)) (PP (IN against) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBD immunoprecipitated) (NP (NP (DT a) (NN histone) (NN H1) (NN kinase)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_) (NN _PROT_)) (VP (VBN produced) (PP (IN in) (NP (FW E.) (FW coli))))) (VP (VP (VBD bound)) (CC and) (VP (VBD activated) (NP (DT the) (NN _PROT1_) (NN protein)) (PP (IN in) (NP (NP (NNS extracts)) (PP (IN from) (NP (JJ human) (NN G1) (NNS cells)))))))) (, ,) (CC and) (S (NP (NP (NNS antibodies)) (PP (IN against) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBD immunoprecipitated) (NP (NP (DT a) (NN histone) (NN H1) (NN kinase)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_)) (, ,) (CC or) (NP (NN _PROT_)) (, ,))))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN at) (NP (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)) (PP (IN in) (NP (JJ human) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT2_)) (, ,))))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN at) (NP (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)) (PP (IN in) (NP (JJ human) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (, ,) (CC or) (NP (NN _PROT2_)) (, ,))))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN at) (NP (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)) (PP (IN in) (NP (JJ human) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD mapped) (NP (NP (DT the) (JJ specific) (NNS domains)) (PP (IN of) (NP (NP (DT the) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBG participating) (PP (IN in) (NP (DT these) (NNS interactions))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP highlight) (NP (NP (DT the) (JJ crucial) (NN role)) (PP (IN of) (NP (DT the) (NN juxtamembrane) (NN domain))) (PP (IN in) (NP (NP (NN signaling)) (PP (IN by) (NP (CC both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT the) (NN calibration))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (CD two) (NNS sets)) (PP (IN of) (NP (NP (NNS proteins)) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ helix-loop-helix) (NNS proteins)) (, ,) (CC and) (NP (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ dimerization-defective))) (NNS versions)) (PP (IN of) (NP (DT the) (NN lambda) (NN cI) (NN repressor))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT the) (NN calibration))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (CD two) (NNS sets)) (PP (IN of) (NP (NP (NNS proteins)) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ helix-loop-helix) (NNS proteins)) (, ,) (CC and) (NP (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ dimerization-defective))) (NNS versions)) (PP (IN of) (NP (DT the) (NN lambda) (NN cI) (NN repressor))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT the) (NN calibration))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (CD two) (NNS sets)) (PP (IN of) (NP (NP (NNS proteins)) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ helix-loop-helix) (NNS proteins)) (, ,) (CC and) (NP (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ dimerization-defective))) (NNS versions)) (PP (IN of) (NP (DT the) (NN lambda) (NN cI) (NN repressor))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (NNS ties) (NP (JJ mitogenic) (NN signal) (NN transduction)) (PP (TO to) (NP (NN cell) (NN cycle) (NN activation))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proto-oncogenes)) (VP (VBP transduce) (NP (NP (JJ extracellular) (NNS signals)) (SBAR (WHNP (WDT that)) (S (VP (VBP promote) (NP (NN cell) (NN growth)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ somatic) (JJ mammalian) (NNS cells))) (CC and) (PP (IN in) (NP (JJ meiotic) (NN frog) (NNS oocytes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (MD can) (VP (VB be) (VP (VBN activated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (DT a) (JJ _PROT2_) (NN manner))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle))) (PP (IN by) (NP (DT the) (NN _PROT1_AND_PROT2_) (NNS pathways)))) (VP (MD might) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle))) (PP (IN by) (NP (DT the) (NN _PROT1_) (NNS pathways)))) (VP (MD might) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle))) (PP (IN by) (NP (DT the) (NN _PROT1_) (NNS pathways)))) (VP (MD might) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN serine/threonine) (NN protein) (NN kinase)) (VP (VBN positioned) (ADVP (RB downstream) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN cascade))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN serine/threonine) (NN protein) (NN kinase)) (VP (VBN positioned) (ADVP (RB downstream) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN cascade))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN serine/threonine) (NN protein) (NN kinase)) (VP (VBN positioned) (ADVP (RB downstream) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN cascade))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN yeast) (JJ two-hybrid) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (JJ other) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP interact) (PP (IN with))) (CC and) (VP (ADVP (RB potentially)) (VBP regulate) (NP (NN _PROT1_))))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD isolated) (NP (NP (DT a) (NN clone)) (VP (VBG encoding) (NP (NP (DT the) (JJ carboxyl-terminal) (NN half)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PP (IN of) (NP (JJ heterotrimeric) (NNS G-proteins)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (FW In) (FW vitro)) (, ,) (NP (VBN purified) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN GST) (NN fusion) (NN protein)) (VP (VBG encoding) (NP (NP (NN amino) (NNS acids) (CD 1-330)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (FW In) (FW vitro)) (, ,) (NP (VBN purified) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN GST) (NN fusion) (NN protein)) (VP (VBG encoding) (NP (NP (NN amino) (NNS acids) (CD 1-330)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (FW In) (FW vitro)) (, ,) (NP (VBN purified) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NNS subunits)) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN GST) (NN fusion) (NN protein)) (VP (VBG encoding) (NP (NP (NN amino) (NNS acids) (CD 1-330)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Binding) (NNS assays)) (PP (IN with) (NP (NP (NN truncation) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN region)) (ADJP (JJ located) (PP (IN between) (NP (NN amino) (NNS acids) (CD 136) (CC and) (CD 239))))) (VP (VBZ is) (NP (NP (DT a) (JJ primary) (NN determinant)) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT2_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT2_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT1_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN formation)) (PP (IN of) (NP (JJ native) (JJ heterotrimeric) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS complexes))) (, ,) (SBAR (IN as) (S (VP (VBN measured) (PP (IN by) (NP (NP (NP (NN pertussis) (NN toxin)) (NN ADP-ribosylation)) (PP (IN of) (NP (NN G) (NN alpha)))))))) (, ,)) (VP (MD could) (VP (VB be) (VP (VBN disrupted) (PP (IN by) (NP (NP (VBG increasing) (NNS amounts)) (PP (IN of) (NP (NN _PROT2_))))) (, ,) (PP (IN with) (NP (NP (DT an) (NN EC50)) (PP (IN of) (NP (QP (RB approximately) (CD 200)) (NN nM))))) (, ,) (PP (IN in) (NP (NP (JJ close) (NN agreement)) (PP (IN with) (NP (DT the) (VBN estimated) (NN binding) (NN affinity))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ human) (JJ embryonic) (NN kidney) (JJ 293-T) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ epitope-tagged) (NN _PROT_) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ human) (JJ embryonic) (NN kidney) (JJ 293-T) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ epitope-tagged) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ human) (JJ embryonic) (NN kidney) (JJ 293-T) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ epitope-tagged) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NP (DT a) (JJ human) (NN G1)) (CC and) (NP (NN S)) (NP (NN phase) (NN protein) (NN phosphatase))) (SBAR (WHNP (WDT that)) (S (VP (VBZ associates) (PP (IN with) (NP (NN _PROT2_))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (DT the) (NN interaction) (NN trap)) (, ,) (NP (NP (DT a) (NN yeast) (JJ genetic) (NN selection)) (PP (IN for) (NP (NN interacting) (NNS proteins)))) (, ,)) (S (VP (TO to) (VP (VB isolate) (NP (NP (NP (JJ human) (JJ _PROT1_) (NN _PROT1_)) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN HeLa) (NNS cells))) (, ,) (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN expressed) (PP (IN at) (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)))))) (, ,) (CC and) (S (NP (DT the) (NN protein)) (VP (VBZ forms) (NP (NP (JJ stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT1_)))) (VP (VBZ delays) (NP (NN progression)) (PP (IN through) (NP (DT the) (NN cell) (NN cycle))) (PP (IN in) (NP (NP (NN yeast)) (CC and) (NP (NN HeLa) (NNS cells)))))) (: ;) (S (NP (NN delay)) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NN _PROT2_) (NN phosphatase) (NN activity)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT the) (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT the) (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT the) (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (CD _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT2_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
+1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT1_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT1_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT2_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT2_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT1_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ SREBP) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN mediated) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT an) (JJ unbiased) (NN search)) (PP (IN for) (NP (NP (JJ potential) (NNS coactivators)) (PP (IN of) (NP (NN SREBP))))))) (, ,) (NP (PRP we)) (VP (VBD isolated) (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (CD 265) (NN kD)))) (PP (IN from) (NP (NP (NN HeLa) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBD bound) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN sequencing)) (CC and) (NP (NN Western) (NN blot) (NN analysis))) (VP (VBD established) (SBAR (IN that) (S (NP (DT the) (JJ 265-kD) (NN protein)) (VP (VBD was) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (ADJP (RB recently) (VBN identified)) (JJ transcriptional) (NN coactivator)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ putative) (NN activation) (NN domain)) (PP (IN of) (NP (NN SREBP)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (JJ amino-terminal) (NNS domains)) (PP (IN of) (NP (NP (JJ recombinant) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (DT a) (JJ _PROT_) (NN protein)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ putative) (NN activation) (NN domain)) (PP (IN of) (NP (NN SREBP)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (JJ amino-terminal) (NNS domains)) (PP (IN of) (NP (NP (JJ recombinant) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (DT a) (JJ _PROT2_) (NN protein)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ putative) (NN activation) (NN domain)) (PP (IN of) (NP (NN SREBP)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (JJ amino-terminal) (NNS domains)) (PP (IN of) (NP (NP (JJ recombinant) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (DT a) (JJ _PROT2_) (NN protein)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT2_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS interactions)) (VP (VBP are) (ADJP (JJ _PROT1_)) (, ,) (SBAR (IN since) (S (NP (NP (DT another) (NN DNA) (JJ repair-related) (NN ubiquitin-conjugating) (NN enzyme)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (DT these) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS interactions)) (VP (VBP are) (ADJP (JJ _PROT1_)) (, ,) (SBAR (IN since) (S (NP (NP (DT another) (NN DNA) (JJ repair-related) (NN ubiquitin-conjugating) (NN enzyme)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (DT these) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS interactions)) (VP (VBP are) (ADJP (JJ _PROT_)) (, ,) (SBAR (IN since) (S (NP (NP (DT another) (NN DNA) (JJ repair-related) (NN ubiquitin-conjugating) (NN enzyme)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (DT these) (NNS proteins))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_) (POS 's)) (NN self-association) (NN region)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_) (POS 's)) (NN self-association) (NN region)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_) (POS 's)) (NN self-association) (NN region)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NNS processes)) (, ,) (NP (NN cell) (NN cycle) (NN control)) (, ,) (NP (JJ _PROT2_) (NN pathway) (-LRB- -LRB-) (NNS s) (-RRB- -RRB-)) (, ,) (CC and) (NP (NN ubiquitination))) (VP (VBP interact) (PP (IN through) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NNS processes)) (, ,) (NP (NN cell) (NN cycle) (NN control)) (, ,) (NP (JJ _PROT_) (NN pathway) (-LRB- -LRB-) (NNS s) (-RRB- -RRB-)) (, ,) (CC and) (NP (NN ubiquitination))) (VP (VBP interact) (PP (IN through) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT_) (NNS processes)) (, ,) (NP (NN cell) (NN cycle) (NN control)) (, ,) (NP (JJ _PROT1_) (NN pathway) (-LRB- -LRB-) (NNS s) (-RRB- -RRB-)) (, ,) (CC and) (NP (NN ubiquitination))) (VP (VBP interact) (PP (IN through) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP find) (SBAR (IN that) (S (NP (NN HIV-1)) (VP (VBZ begins) (NP (JJ reverse) (NN transcription)) (ADVP (RB much) (RBR more) (RB efficiently)) (PP (IN in) (NP (NP (NNS DCs)) (PP (IN than) (NP (NN T) (NNS cells))))) (, ,) (SBAR (RB even) (IN though) (S (NP (NN T) (NNS cells)) (VP (VBP have) (NP (NP (JJR higher) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN binding))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_) (NNS receptors))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS DCs)) (VP (VBP express) (NP (NP (RBR more) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN mRNA)))) (PP (IN than) (NP (NN T) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ transcriptional) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ communicates) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ transcriptional) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ communicates) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ transcriptional) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ communicates) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ transactivates) (NP (ADJP (ADJP (JJ viral)) (CC and) (ADJP (JJ cellular))) (NNS genes)) (PP (IN through) (NP (NP (DT a) (JJ wide) (NN variety)) (PP (IN of) (NP (NNS cis-elements))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN context))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP interact) (PP (IN with) (NP (JJ other) (JJ general) (NN transcription) (NNS factors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Delineation)) (PP (IN of) (NP (NP (DT the) (NN binding) (NNS regions)) (PP (IN of) (NP (DT these) (CD three) (NNS proteins)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NP (DT each))) (VP (VBZ has) (NP (NP (CD two) (NN binding) (NNS regions)) (PP (IN for) (NP (DT the) (JJ other) (CD two) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Delineation)) (PP (IN of) (NP (NP (DT the) (NN binding) (NNS regions)) (PP (IN of) (NP (DT these) (CD three) (NNS proteins)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NP (DT each))) (VP (VBZ has) (NP (NP (CD two) (NN binding) (NNS regions)) (PP (IN for) (NP (DT the) (JJ other) (CD two) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Delineation)) (PP (IN of) (NP (NP (DT the) (NN binding) (NNS regions)) (PP (IN of) (NP (DT these) (CD three) (NNS proteins)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (NP (DT each))) (VP (VBZ has) (NP (NP (CD two) (NN binding) (NNS regions)) (PP (IN for) (NP (DT the) (JJ other) (CD two) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT2_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT1_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT1_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (JJ new) (JJ cytokine-receptor) (NN binding) (NN mode)) (VP (VBN revealed) (PP (IN by) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (PP (IN with) (NP (DT an) (NN antagonist))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Inflammation)) (, ,) (ADVP (RB regardless) (PP (IN of) (SBAR (IN whether) (S (NP (PRP it)) (VP (VBZ is) (VP (VBD provoked) (PP (PP (IN by) (NP (NN infection))) (CC or) (PP (IN by) (NP (NN tissue) (NN damage)))))))))) (, ,) (VP (VBZ starts) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (NNS macrophages)) (SBAR (WHNP (WDT which)) (S (VP (VBP initiate) (NP (NP (DT a) (NN cascade)) (PP (IN of) (NP (JJ inflammatory) (NNS responses)))) (PP (IN by) (S (VP (VBG producing) (NP (NP (DT the) (NNS cytokines)) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 1)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Inflammation)) (, ,) (ADVP (RB regardless) (PP (IN of) (SBAR (IN whether) (S (NP (PRP it)) (VP (VBZ is) (VP (VBD provoked) (PP (PP (IN by) (NP (NN infection))) (CC or) (PP (IN by) (NP (NN tissue) (NN damage)))))))))) (, ,) (VP (VBZ starts) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (NNS macrophages)) (SBAR (WHNP (WDT which)) (S (VP (VBP initiate) (NP (NP (DT a) (NN cascade)) (PP (IN of) (NP (JJ inflammatory) (NNS responses)))) (PP (IN by) (S (VP (VBG producing) (NP (NP (DT the) (NNS cytokines)) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 1)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Inflammation)) (, ,) (ADVP (RB regardless) (PP (IN of) (SBAR (IN whether) (S (NP (PRP it)) (VP (VBZ is) (VP (VBD provoked) (PP (PP (IN by) (NP (NN infection))) (CC or) (PP (IN by) (NP (NN tissue) (NN damage)))))))))) (, ,) (VP (VBZ starts) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (NNS macrophages)) (SBAR (WHNP (WDT which)) (S (VP (VBP initiate) (NP (NP (DT a) (NN cascade)) (PP (IN of) (NP (JJ inflammatory) (NNS responses)))) (PP (IN by) (S (VP (VBG producing) (NP (NP (DT the) (NNS cytokines)) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 1)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN at) (NP (NP (CD 2.7) (DT A) (NN resolution)) (PP (IN of) (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NN part)) (PP (IN of) (NP (NP (JJ _PROT2_) (NN _PROT1_AND_PROT2_)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN at) (NP (NP (CD 2.7) (DT A) (NN resolution)) (PP (IN of) (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NN part)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT1_)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN at) (NP (NP (CD 2.7) (DT A) (NN resolution)) (PP (IN of) (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NN part)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ important) (PP (IN for) (NP (NP (JJ biological) (NN function)) (PP (IN in) (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (`` ') (NN receptor) (NN trigger) (NN site) ('' '))))))))))) (VP (VBZ is) (RB not) (PP (IN in) (NP (NP (JJ direct) (NN contact)) (PP (IN with) (NP (NP (DT the) (NN receptor)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN interaction)) (PP (IN between) (NP (DT the) (NN bHLHZip) (NN _PROT1_) (CC and) (NN bZip) (NN _PROT2_) (NNS proteins)))) (VP (VBZ results) (PP (IN in) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NN _PROT_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN interaction)) (PP (IN between) (NP (DT the) (NN bHLHZip) (NN _PROT1_) (CC and) (NN bZip) (NN _PROT_) (NNS proteins)))) (VP (VBZ results) (PP (IN in) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN interaction)) (PP (IN between) (NP (DT the) (NN bHLHZip) (NN _PROT_) (CC and) (NN bZip) (NN _PROT1_) (NNS proteins)))) (VP (VBZ results) (PP (IN in) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (ADVP (RB further)) (VP (VB examine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (DT the) (NN bHLHZip) (NN protein)) (, ,) (NP (NN _PROT1_)))))))) (, ,) (NP (PRP we)) (VP (VBD screened) (PP (IN for) (NP (NP (JJ cellular) (NNS proteins)) (SBAR (WHNP (WDT which)) (S (VP (MD could) (ADVP (RB directly)) (VP (VB interact) (PP (IN with) (NP (NP (NN _PROT2_)) (VP (VBG using) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN bZip) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (ADVP (RB efficiently)) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT2_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN bHLHZip)) (CC and) (NP (NP (DT the) (JJ N-terminal) (NNS regions)) (PP (IN of) (NP (NN _PROT1_))))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ efficient) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NN association)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBZ has) (VP (VBN been) (VP (VBN demonstrated) (PP (IN by) (NP (NN co-immunoprecipitation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (JJ exogenous) (NN _PROT1_)))) (VP (VBD led) (PP (TO to) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (JJ _PROT2_) (NN transcription)) (PP (IN in) (NP (NN F9) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (JJ exogenous) (NN _PROT1_)))) (VP (VBD restored) (NP (DT the) (NN _PROT2_) (NN activity)) (PP (IN in) (NP (DT a) (JJ dose-dependent) (NN manner))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (ADVP (RB physically)) (CC and) (ADVP (RB functionally))) (VP (VBP interact) (S (VP (VBG demonstrating) (SBAR (IN that) (S (NP (NN cross-talk)) (VP (VBZ occurs) (PP (IN between) (NP (NP (NNS factors)) (PP (IN of) (NP (ADJP (RB distantly) (JJ related)) (NN transcription) (NNS families))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN between) (NP (NP (NN _PROT1_) (NN protein)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN DNA) (NN damage))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN gene)) (VP (VBN mutated) (PP (IN in) (NP (NP (DT the) (JJ autosomal) (JJ recessive) (NN disorder)) (NP (NP (NN ataxia) (NN telangiectasia)) (PRN (-LRB- -LRB-) (NP (NN AT)) (-RRB- -RRB-))))))) (, ,) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (PP (IN for) (ADJP (`` ') (NN _PROT2_) (JJ _PROT2_) ('' '))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ phosphatidylinositol-3-kinase-like) (NNS enzymes)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (NP (JJ cell-cycle) (NN control)) (, ,) (NP (JJ meiotic) (NN recombination)) (, ,) (NP (NN telomere) (NN length) (NN monitoring)) (CC and) (NP (NN DNA-damage) (NN response))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (NNS cells)) (VP (VBG lacking) (NP (DT the) (NP (NN protein) (NN tyrosine) (NN kinase)) (NN _PROT1_)))) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ defective) (PP (IN in) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD might) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN radiation) (NN damage)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (NNS cells)) (VP (VBG lacking) (NP (DT the) (NP (NN protein) (NN tyrosine) (NN kinase)) (NN _PROT1_)))) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ defective) (PP (IN in) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD might) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN radiation) (NN damage)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (NNS cells)) (VP (VBG lacking) (NP (DT the) (NP (NN protein) (NN tyrosine) (NN kinase)) (NN _PROT_)))) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ defective) (PP (IN in) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD might) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN radiation) (NN damage)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NN _PROT2_)) (ADVP (RB constitutively)) (PP (PP (IN in) (NP (NN control) (NNS cells))) (CC but) (PP (RB not) (IN in) (NP (NN AT) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT the) (NN SH3) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (DT a) (NN DPAPNPPHFP) (NN motif)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 1,373-1,382))) (-RRB- -RRB-))) (PP (IN of) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN DNA) (NN damage)))))))) (CC and) (S (NP (DT this) (NN interaction)) (VP (MD may) (PP (IN in) (NP (NN part))) (VP (VB mediate) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT2_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT2_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT2_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NP (NP (DT the) (JJ first) (CD 82) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (NP (NN AAs)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN AAs) (CD 265-346)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (DT the) (JJ betaL) (NN chain)))))) (VP (VBP are) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT1_) (NN pathway))) (CC and) (VP (VB trigger) (NP (DT an) (JJ antiviral) (NN state)) (PP (IN after) (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (DT the) (NN receptor))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN region)) (PP (IN of) (NP (DT the) (JJ betaL) (NN chain))) (, ,) (VP (VBN required) (PP (IN for) (NP (NP (NN _PROT1_) (NN binding)) (CC and) (NP (NN activation))))) (, ,)) (VP (VBZ contains) (NP (NP (DT the) (NN Box) (CD 1) (NN motif)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT some) (NN cytokine) (NNS receptors))) (PP (IN with) (NP (NN _PROT2_) (NNS kinases)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN between) (NP (NP (NN cell) (NN cycle) (NN regulator)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBZ mediates) (NP (NP (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN gene) (NN transcription)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_AND_PROT2_) (NN family)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBZ is) (NP (NP (CD one)) (PP (IN of) (NP (NP (DT the) (JJ main) (NNS targets)) (PP (IN of) (NP (NP (NNS cytokines)) (CC and) (NP (JJ other) (NNS agents)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP induce) (NP (NN HIV-1) (NN gene) (NN expression)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT Some)) (PP (IN of) (NP (DT these) (JJ extracellular) (NNS stimuli)))) (VP (VP (VB arrest) (NP (NP (NNS cells)) (PP (IN in) (NP (NP (DT the) (NN G1) (NN phase)) (PP (IN of) (NP (DT the) (JJ mitotic) (NN division) (NN cycle))))))) (CC and) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN tumor) (NN suppressor) (NP (NN protein) (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN partner)) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT_) (NN subunit) (, ,) (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN subunit) (, ,) (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT_) (NN subunit) (, ,) (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN subunit) (, ,) (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT_) (NN subunit) (, ,) (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN subunit) (, ,) (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Gel) (NN retardation)) (CC and) (NP (NN methylation) (NN interference))) (NNS assays)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ able) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT a) (NN site)) (ADJP (JJ embedded) (PP (IN within) (NP (DT the) (CD two) (NN _PROT2_) (NNS elements))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Gel) (NN retardation/immunoblot) (NN analysis)) (VP (VBG using) (NP (VBN purified) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS homodimers)))) (VP (VBZ reveals) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NNS complexes)) (VP (VBG containing) (NP (DT both) (NNS proteins)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Affinity) (NN chromatography)) (CC and) (NP (NN co-immunoprecipitation) (NNS assays))) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN for) (NP (NP (JJ direct) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (PRP$ their) (NN DNA) (NN target) (NNS sequences)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN transcription) (NN assay)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ represses) (NP (NN _PROT2_) (JJ mediated) (NN transcription)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NNS studies)) (PP (IN in) (NP (NN Jurkat) (NN T) (JJ lymphocytic) (NNS cells)))) (VP (VBP point) (PP (TO to) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (CC both) (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NN binding) (NNS sites))) (PP (IN in) (NP (NP (NN _PROT_) (JJ mediated) (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN promoter))))))) (, ,) (ADVP (FW in) (FW vivo)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NNS studies)) (PP (IN in) (NP (NN Jurkat) (NN T) (JJ lymphocytic) (NNS cells)))) (VP (VBP point) (PP (TO to) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (CC both) (DT the) (NN _PROT1_) (CC and) (NN _PROT_) (NN binding) (NNS sites))) (PP (IN in) (NP (NP (NN _PROT2_) (JJ mediated) (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN promoter))))))) (, ,) (ADVP (FW in) (FW vivo)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NNS studies)) (PP (IN in) (NP (NN Jurkat) (NN T) (JJ lymphocytic) (NNS cells)))) (VP (VBP point) (PP (TO to) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (CC both) (DT the) (NN _PROT_) (CC and) (NN _PROT1_) (NN binding) (NNS sites))) (PP (IN in) (NP (NP (NN _PROT2_) (JJ mediated) (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN promoter))))))) (, ,) (ADVP (FW in) (FW vivo)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activity)) (VP (MD may) (VP (VB be) (VP (VBN regulated) (PP (IN by) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein)) (, ,) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NP (NN glucocorticoid) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NNS GRs)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (DT the) (JJ nasal) (NNS polyps)) (PP (IN of) (NP (JJ nonallergic) (NNS patients)))))) (SBAR (IN as) (S (VP (VBN compared) (PP (IN with) (NP (JJ normal) (NNS controls)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (S (PP (IN in) (NP (JJ normal) (JJ nasal) (NNS tissues))) (, ,) (NP (NN _PROT1_) (NN labeling)) (VP (VBD was) (ADVP (RB only)) (VP (VBN found) (PP (IN in) (NP (DT the) (JJ vascular) (NN wall)))))) (, ,) (CC and) (S (NP (DT the) (NN expression)) (VP (VBD was) (NP (JJ weaker--a) (NN finding)) (S (VP (VBG demonstrating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN in) (NP (JJ nasal) (NNS polyps)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Therefore)) (, ,) (NP (LST (LS 1) (-RRB- -RRB-)) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NNS GRs)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (JJ nasal) (NNS polyps)) (PP (IN from) (NP (JJ nonallergic) (NNS patients)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN upregulation)) (PP (IN of) (NP (NN _PROT2_) (NN expression)))) (, ,)) (VP (VBZ suggests) (SBAR (IN that) (S (S (NP (NN inflammation)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (DT the) (NN pathophysiology)) (PP (IN of) (NP (JJ nasal) (NNS polyps)))))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN glucocorticoid)) (VP (MD could) (VP (VB be) (NP (NP (DT a) (JJ potential) (NN treatment) (NN method)) (PP (IN for) (S (VP (VBG suppressing) (NP (JJ inflammatory) (NNS processes)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN superfamily)))) (, ,)) (VP (VBZ has) (NP (JJ various) (NNS effects)) (PP (IN on) (NP (NP (JJ diverse) (JJ biological) (NNS systems)) (, ,) (PP (VBG including) (NP (NP (NN cell) (NN growth) (NN inhibition)) (PP (IN in) (NP (JJ many) (NN cell) (NNS types))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Native) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD formed) (NP (NP (DT a) (NN heterodimer)) (PP (IN in) (NP (NN solution))) (PP (IN of) (NP (JJ physiological) (JJ ionic) (NN strength)))) (PP (IN with) (NP (NP (NP (DT a) (JJ free-energy) (NN change) (NN DeltaG) (NNS degrees)) (PP (IN of) (NP (CD -8.3) (NN kcal/mol)))) (CC and) (NP (NP (NP (DT a) (NN dissociation) (NN constant)) (NN Kd)) (PP (IN of) (NP (NP (NP (CD 0.6) (NN microM)) (PRN (-LRB- -LRB-) (PP (IN at) (NP (CD 20) (NNS degrees) (NN C))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (NP (NP (JJ ionic) (NN strength-)) (CC and) (NP (NN temperature-dependent)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ va) (ADJP (RB n't) (JJ Hoff)) (NN plot)) (PP (IN of) (NP (NP (DT the) (NN change)) (PP (IN in) (NP (NN Kd)))))) (VP (VP (VBD was) (ADJP (JJ linear) (PP (IN between) (NP (CD 10) (CC and) (CD 37) (NNS degrees) (NN C))))) (CC and) (VP (VBD yielded) (NP (NP (NNS values)) (PP (IN of) (NP (NP (NP (NP (JJ DeltaH) (NNS degrees)) (VP (VBG =) (NP (CD -12.9) (NN kcal/mol)))) (CC and) (NP (NN DeltaS) (NNS degrees))) (VP (JJ =) (NP (CD -15.9) (JJ cal) (NN mol-1) (NN deg-1))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (JJ electrostatic) (NNS forces)) (VP (VBP play) (NP (DT a) (JJ prominent) (NN role)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (JJ Native) (NN _PROT1_)) (ADVP (RB also)) (VP (VBD formed) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NN _PROT2_)))))) (, ,) (CC and) (S (NP (NP (JJ low) (NNS concentrations)) (PP (IN of) (NP (NP (JJ polyionic) (NNS ligands)) (PP (JJ such) (IN as) (NP (NP (NN protamine)) (CC and) (NP (NN suramin))))))) (VP (VBD inhibited) (NP (DT the) (NN interaction))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Suramin)) (VP (VBD induced) (NP (NP (JJ high-affinity) (NN trimerization)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 0.10) (NN microM)) (PP (IN at) (NP (CD 20) (NNS degrees) (NN C))) (-RRB- -RRB-))) (CC and) (NP (NP (NN dimerization) (IN of) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 0.86) (NN microM)) (PP (IN at) (NP (CD 20) (NNS degrees) (NN C))) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Analysis)) (PP (PP (IN of) (NP (NN sedimentation) (NNS equilibria))) (CC and) (ADVP (RB also)) (PP (IN of) (NP (NP (DT the) (NN fluorescence) (NN enhancement)) (PP (IN of) (NP (NN suramin)))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN bound) (PP (TO to) (NP (NN protein))))))) (VP (VBD provided) (NP (NP (NN evidence)) (PP (IN for) (NP (NP (CD two) (JJ suramin-binding) (NNS sites)) (PP (IN on) (NP (NP (DT each) (NP (NN _PROT1_)) (CC and) (NP (CD three))) (PP (IN on) (NP (DT each) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NNS oligomers))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN ectodomain) (NN complex))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Bone) (NN morphogenetic) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN BMPs)) (-RRB- -RRB-))) (VP (VBP belong) (PP (TO to) (NP (NP (DT the) (JJ large) (NP (NP (VBG _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN superfamily)) (PP (IN of) (NP (JJ multifunctional) (NNS cytokines))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT1_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (JJ _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT1_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT1_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT_) (NN _PROT_) (NN _PROT_) (JJ _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN receptor) (NNS chains)) (VP (VBP bind) (PP (TO to) (NP (NP (DT the) (`` ') (NN wrist) (POS ') (NNS epitopes)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN dimer) (CC and) (NN contact) (CC both) (NN _PROT2_) (NNS monomers))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN ectodomain))) (PP (IN in) (NP (NP (DT a) (JJ dimeric) (NN form)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN induced) (PP (IN by) (NP (NP (JJ simultaneous) (NN binding)) (PP (TO to) (NP (NP (NN _PROT2_)) (CC and) (NP (DT a) (NN heparin)) (NP (NN decasaccharide))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT1_AND_PROT2_) (JJ ternary) (NN complex)))) (VP (VBZ provides) (NP (NP (DT a) (JJ structural) (NN basis)) (PP (IN for) (NP (NP (DT the) (JJ essential) (NN role)) (PP (IN of) (NP (NN heparan) (NN sulphate))) (PP (IN in) (NP (NN FGF) (NN signalling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Kaposi) (POS 's) (JJ sarcoma-associated) (NN herpesvirus)) (VP (VBZ encodes) (NP (NP (DT a) (JJ functional) (NN homolog)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Kaposi) (POS 's) (JJ sarcoma-associated) (NN herpesvirus)) (VP (VBZ encodes) (NP (NP (DT a) (JJ functional) (NN homolog)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Kaposi) (POS 's) (JJ sarcoma-associated) (NN herpesvirus)) (VP (VBZ encodes) (NP (NP (DT a) (JJ functional) (NN homolog)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT1_)) (CC and) (NP (JJ human) (NN _PROT2_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT1_)) (CC and) (NP (JJ human) (NN _PROT_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT1_)) (CC and) (NP (JJ human) (NN _PROT_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT_)) (CC and) (NP (JJ human) (NN _PROT1_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT_)) (CC and) (NP (JJ human) (NN _PROT1_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT_)) (CC and) (NP (JJ human) (NN _PROT_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT1_AND_PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cross-reactivity)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (RB apparently) (JJ due) (PP (TO to) (NP (NP (DT a) (JJ chemical) (NN plasticity)) (ADJP (JJ evident) (PP (IN in) (NP (DT the) (JJ amphipathic) (NN _PROT2_) (JJ cytokine-binding) (NNS sites))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (DT the) (NN oligomerization)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS products)) (ADJP (FW in) (FW vivo))))))) (VP (VBG using) (NP (DT a) (JJ two-hybrid) (NN assay) (NN system))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT2_) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT_) (NN gene) (NNS products)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT_) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT1_) (NN gene) (NNS products)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT1_) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT_) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (S (NP (NN _PROT1_)) (VP (VBZ heterodimerizes) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ does) (RB not) (VP (VB homodimerize) (PP (TO to) (NP (DT a) (JJ measurable) (NN extent)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (S (NP (NN _PROT1_)) (VP (VBZ heterodimerizes) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ does) (RB not) (VP (VB homodimerize) (PP (TO to) (NP (DT a) (JJ measurable) (NN extent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (S (NP (NN _PROT_)) (VP (VBZ heterodimerizes) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ does) (RB not) (VP (VB homodimerize) (PP (TO to) (NP (DT a) (JJ measurable) (NN extent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT2_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT2_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT2_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (JJ cysteine-rich) (NN domain)) (PP (IN of) (NP (DT the) (NN TNF-R)))) (VP (VBZ is) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (NP (NN nerve) (NN growth) (NN factor)) (NN receptor)) (CC and) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Unlabeled) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADJP (RB equally) (JJ effective) (PP (IN at) (S (VP (VBG displacing) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (JJ labeled) (NN _PROT_))) (PP (TO to) (NP (NN TNF-R) (NN expressing) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Unlabeled) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADJP (RB equally) (JJ effective) (PP (IN at) (S (VP (VBG displacing) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (JJ labeled) (NN _PROT2_))) (PP (TO to) (NP (NN TNF-R) (NN expressing) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Unlabeled) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADJP (RB equally) (JJ effective) (PP (IN at) (S (VP (VBG displacing) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (JJ labeled) (NN _PROT2_))) (PP (TO to) (NP (NN TNF-R) (NN expressing) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Identification)) (PP (IN of) (NP (NP (DT an) (JJ 11-kDa) (JJ _PROT1_) (NN domain)) (PP (IN within) (NP (DT the) (JJ 289-kDa) (JJ _PROT2_) (NN _PROT2_)))))) (CC and) (NP (NP (NN characterization)) (PP (IN of) (NP (DT a) (JJ critical) (NN serine) (NN residue))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (S (ADVP (RB Previously)) (, ,) (NP (NP (DT a) (JJ mammalian) (NN protein)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT1_))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN identified))))) (CC and) (NP (PRP$ its) (VBG encoding) (NN gene)) (VP (VBZ has) (VP (VBN been) (VP (VBN cloned) (PP (IN from) (NP (DT both) (JJ human) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT2_)) (-RRB- -RRB-)) (NN [Brown))) (PRN (, ,) (NP (NP (NNP E.J.) (, ,) (NNP Albers) (, ,) (NN M.W.) (, ,) (NP (NNP Shin) (, ,) (NNP T.B.) (, ,) (NNP Ichikawa) (, ,) (NNP K.) (, ,) (NNP Keith) (, ,) (NNP C.T.) (, ,) (NNP Lane) (, ,) (NNP W.S.) (NNP &) (NNP Schreiber) (, ,) (NNP S.L.))) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Nature) (-LRB- -LRB-) (NNP London) (-RRB- -RRB-) (: 369)) (, ,) (NP (CD 756-758) (-RRB- -RSB-) (CC and) (NN rat) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT_)) (-RRB- -RRB-)) (NNS [Sabatini)) (, ,) (NP (NNP D.M.) (, ,) (NN Erdjument-Bromage) (, ,) (NNP H.) (, ,) (NNP Lui) (, ,) (NNP M.) (, ,) (NNP Tempst) (, ,) (NNP P.) (NNP &) (NNP Snyder) (, ,) (NNP S.H.)) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Cell) (CD 78)) (, ,) (NP (NN 35-43))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Previously)) (, ,) (NP (NP (DT a) (JJ mammalian) (NN protein)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT1_))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN identified))))) (CC and) (NP (PRP$ its) (VBG encoding) (NN gene)) (VP (VBZ has) (VP (VBN been) (VP (VBN cloned) (PP (IN from) (NP (DT both) (JJ human) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT_)) (-RRB- -RRB-)) (NN [Brown))) (PRN (, ,) (NP (NP (NNP E.J.) (, ,) (NNP Albers) (, ,) (NN M.W.) (, ,) (NP (NNP Shin) (, ,) (NNP T.B.) (, ,) (NNP Ichikawa) (, ,) (NNP K.) (, ,) (NNP Keith) (, ,) (NNP C.T.) (, ,) (NNP Lane) (, ,) (NNP W.S.) (NNP &) (NNP Schreiber) (, ,) (NNP S.L.))) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Nature) (-LRB- -LRB-) (NNP London) (-RRB- -RRB-) (: 369)) (, ,) (NP (CD 756-758) (-RRB- -RSB-) (CC and) (NN rat) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT2_)) (-RRB- -RRB-)) (NNS [Sabatini)) (, ,) (NP (NNP D.M.) (, ,) (NN Erdjument-Bromage) (, ,) (NNP H.) (, ,) (NNP Lui) (, ,) (NNP M.) (, ,) (NNP Tempst) (, ,) (NNP P.) (NNP &) (NNP Snyder) (, ,) (NNP S.H.)) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Cell) (CD 78)) (, ,) (NP (NN 35-43))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Previously)) (, ,) (NP (NP (DT a) (JJ mammalian) (NN protein)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT_))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN identified))))) (CC and) (NP (PRP$ its) (VBG encoding) (NN gene)) (VP (VBZ has) (VP (VBN been) (VP (VBN cloned) (PP (IN from) (NP (DT both) (JJ human) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT1_)) (-RRB- -RRB-)) (NN [Brown))) (PRN (, ,) (NP (NP (NNP E.J.) (, ,) (NNP Albers) (, ,) (NN M.W.) (, ,) (NP (NNP Shin) (, ,) (NNP T.B.) (, ,) (NNP Ichikawa) (, ,) (NNP K.) (, ,) (NNP Keith) (, ,) (NNP C.T.) (, ,) (NNP Lane) (, ,) (NNP W.S.) (NNP &) (NNP Schreiber) (, ,) (NNP S.L.))) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Nature) (-LRB- -LRB-) (NNP London) (-RRB- -RRB-) (: 369)) (, ,) (NP (CD 756-758) (-RRB- -RSB-) (CC and) (NN rat) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT2_)) (-RRB- -RRB-)) (NNS [Sabatini)) (, ,) (NP (NNP D.M.) (, ,) (NN Erdjument-Bromage) (, ,) (NNP H.) (, ,) (NNP Lui) (, ,) (NNP M.) (, ,) (NNP Tempst) (, ,) (NNP P.) (NNP &) (NNP Snyder) (, ,) (NNP S.H.)) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Cell) (CD 78)) (, ,) (NP (NN 35-43))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription/translation) (NN assay) (NN method)) (VP (VBN coupled) (PP (IN with) (NP (NN proteolysis) (NNS studies))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT an) (JJ 11-kDa) (JJ _PROT1_) (NN domain)) (PP (IN within) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT_)) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_AND_PROT2_) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT_)) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (NN protein) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN tumor-suppressor) (NN gene)))) (, ,)) (VP (VBZ regulates) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (JJ specific) (NN transcription) (NNS factors)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription))) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (ADVP (RB partially)) (VP (VBN abrogated) (PP (IN at) (NP (NP (DT the) (JJ nonpermissive) (NN temperature)) (PP (IN in) (NP (NN ts13) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NN _PROT_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT_)) (NP (NN _PROT2_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT_)) (NP (NN _PROT_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT1_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN stimulation)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription))) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN ts13) (NNS cells)) (PP (IN at) (NP (DT the) (JJ nonpermissive) (NN temperature)))))) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN introduction)) (PP (IN of) (NP (JJ wild-type) (JJ human) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN stimulation)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription))) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN ts13) (NNS cells)) (PP (IN at) (NP (DT the) (JJ nonpermissive) (NN temperature)))))) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN introduction)) (PP (IN of) (NP (JJ wild-type) (JJ human) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN stimulation)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN ts13) (NNS cells)) (PP (IN at) (NP (DT the) (JJ nonpermissive) (NN temperature)))))) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN introduction)) (PP (IN of) (NP (JJ wild-type) (JJ human) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (CD _PROT2_))) (ADVP (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB confer) (NP (NP (JJ transcriptional) (NN regulation)) (CC and) (ADVP (RB possibly)) (NP (NN cell) (NN cycle) (NN control)) (CC and) (NP (NN tumor) (NN suppression))) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (PP (IN in) (NP (NP (JJ particular)) (PP (IN with) (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB confer) (NP (NP (JJ transcriptional) (NN regulation)) (CC and) (ADVP (RB possibly)) (NP (NN cell) (NN cycle) (NN control)) (CC and) (NP (NN tumor) (NN suppression))) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT_))))) (, ,) (PP (IN in) (NP (NP (JJ particular)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD can) (VP (VB confer) (NP (NP (JJ transcriptional) (NN regulation)) (CC and) (ADVP (RB possibly)) (NP (NN cell) (NN cycle) (NN control)) (CC and) (NP (NN tumor) (NN suppression))) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT1_))))) (, ,) (PP (IN in) (NP (NP (JJ particular)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN inhibitor)) (PP (IN of) (NP (JJ cyclin-dependent) (NNS kinases)))) (VP (VBZ controls) (NP (NN DNA) (NN replication)) (PP (IN by) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN tumour-suppressor) (NN protein)) (VP (VBZ controls) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN gene)) (VP (VBG encoding) (NP (DT the) (NP (NP (NN _PROT2_) (JJ cyclin-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NN regulator)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NN _PROT1_) (NN protein)))) (VP (VBP are) (VP (VBN increased) (PP (IN in) (NP (JJ senescent) (NNS cells)))))) (CC and) (S (NP (NN _PROT2_) (NN overexpression)) (VP (VBZ blocks) (NP (NP (DT the) (NN growth)) (PP (IN of) (NP (NN tumour) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (PP (IN In) (NP (JJ normal) (JJ human) (NNS cells))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ many) (NN tumour) (NNS cells)))) (, ,) (NP (NN _PROT1_)) (VP (VBZ exists) (PP (IN in) (NP (NP (DT a) (JJ quaternary) (NN complex)) (PP (IN with) (NP (NP (DT a) (NN cyclin)) (, ,) (NP (DT a) (NN CDK)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (PP (IN In) (NP (JJ normal) (JJ human) (NNS cells))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ many) (NN tumour) (NNS cells)))) (, ,) (NP (NN _PROT1_)) (VP (VBZ exists) (PP (IN in) (NP (NP (DT a) (JJ quaternary) (NN complex)) (PP (IN with) (NP (NP (DT a) (NN cyclin)) (, ,) (NP (DT a) (NN CDK)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (PP (IN In) (NP (JJ normal) (JJ human) (NNS cells))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ many) (NN tumour) (NNS cells)))) (, ,) (NP (NN _PROT_)) (VP (VBZ exists) (PP (IN in) (NP (NP (DT a) (JJ quaternary) (NN complex)) (PP (IN with) (NP (NP (DT a) (NN cyclin)) (, ,) (NP (DT a) (NN CDK)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ controls) (NP (NN CDK) (NN activity)) (, ,) (S (ADVP (RB thereby)) (VP (VBG affecting) (NP (JJ cell-cycle) (NN control)))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VBZ functions) (PP (IN in) (NP (CC both) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP use) (NP (NP (JJ simian) (NN virus) (CD 40)) (NN DNA) (NN replication)) (ADVP (FW in) (FW vitro)) (S (VP (TO to) (VP (VB show) (SBAR (IN than) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ inhibits) (NP (JJ _PROT2_) (NN DNA) (NN replication)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN a) (CD cyclin/CDK)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT1_)) (VP (VBZ blocks) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (DT the) (JJ principal) (JJ replicative) (NN DNA) (NN polymerase))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT1_)) (VP (VBZ blocks) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT the) (JJ principal) (JJ replicative) (NN DNA) (NN polymerase))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT_)) (VP (VBZ blocks) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT the) (JJ principal) (JJ replicative) (NN DNA) (NN polymerase))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN regulation)) (VP (VBZ results) (PP (IN from) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (NP (JJ _PROT1_) (NN suppression)) (PP (IN of) (NP (NN cell) (NN proliferation))))) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN for) (S (VP (VBG coordinating) (NP (NP (NP (JJ cell-cycle) (NN progression)) (, ,) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))) (PP (IN of) (NP (JJ damaged) (NN DNA))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (NP (JJ _PROT1_) (NN suppression)) (PP (IN of) (NP (NN cell) (NN proliferation))))) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN for) (S (VP (VBG coordinating) (NP (NP (NP (JJ cell-cycle) (NN progression)) (, ,) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))) (PP (IN of) (NP (JJ damaged) (NN DNA))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (NP (JJ _PROT_) (NN suppression)) (PP (IN of) (NP (NN cell) (NN proliferation))))) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN for) (S (VP (VBG coordinating) (NP (NP (NP (JJ cell-cycle) (NN progression)) (, ,) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))) (PP (IN of) (NP (JJ damaged) (NN DNA))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Nuclear) (NN protein) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (DT the) (NN transcription) (NN factor) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN of) (NP (NN M) (-LRB- -LRB-) (NN r) (-RRB- -RRB-) (CD 265K)))) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT the) (JJ _PROT2_) (NN form)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN of) (NP (NN M) (-LRB- -LRB-) (NN r) (-RRB- -RRB-) (CD 265K)))) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT the) (JJ _PROT_) (NN form)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN of) (NP (NN M) (-LRB- -LRB-) (NN r) (-RRB- -RRB-) (CD 265K)))) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT the) (JJ _PROT1_) (NN form)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NN fluorescence) (NN anisotropy) (NNS measurements)) (S (VP (VP (TO to) (VP (VB define) (NP (NP (DT the) (NN equilibrium) (NN binding) (NNS parameters)) (PP (IN of) (NP (DT the) (NN _PROT1_) (: :) (NN _PROT2_) (NN interaction)))))) (CC and) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD can) (VP (VB activate) (NP (NN transcription)) (PP (IN through) (NP (NP (DT a) (NN region)) (PP (IN in) (NP (PRP$ its) (NN carboxy) (NN terminus))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NN fluorescence) (NN anisotropy) (NNS measurements)) (S (VP (VP (TO to) (VP (VB define) (NP (NP (DT the) (NN equilibrium) (NN binding) (NNS parameters)) (PP (IN of) (NP (DT the) (NN _PROT1_) (: :) (NN _PROT_) (NN interaction)))))) (CC and) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD can) (VP (VB activate) (NP (NN transcription)) (PP (IN through) (NP (NP (DT a) (NN region)) (PP (IN in) (NP (PRP$ its) (NN carboxy) (NN terminus))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NN fluorescence) (NN anisotropy) (NNS measurements)) (S (VP (VP (TO to) (VP (VB define) (NP (NP (DT the) (NN equilibrium) (NN binding) (NNS parameters)) (PP (IN of) (NP (DT the) (NN _PROT_) (: :) (NN _PROT1_) (NN interaction)))))) (CC and) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD can) (VP (VB activate) (NP (NN transcription)) (PP (IN through) (NP (NP (DT a) (NN region)) (PP (IN in) (NP (PRP$ its) (NN carboxy) (NN terminus))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ basal) (NN transcription) (NN factor) (NN _PROT2_))) (PP (IN through) (NP (NP (DT a) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN in) (NP (NP (DT the) (NN yeast) (NN coactivator) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 8)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ basal) (NN transcription) (NN factor) (NN _PROT_))) (PP (IN through) (NP (NP (DT a) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN in) (NP (NP (DT the) (NN yeast) (NN coactivator) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 8)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ basal) (NN transcription) (NN factor) (NN _PROT1_))) (PP (IN through) (NP (NP (DT a) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN in) (NP (NP (DT the) (NN yeast) (NN coactivator) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 8)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (ADJP (JJ Consistent) (PP (IN with) (NP (NP (PRP$ its) (NN role)) (PP (IN as) (NP (DT a) (NN coactivator))))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ augments) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (VBN phosphorylated) (NN _PROT2_)))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (JJ cAMP-responsive) (NNS genes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Cloning)) (PP (IN of) (NP (NP (DT the) (JJ complete) (NN coding) (NN region)) (PP (IN for) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (VP (VBG using) (NP (NP (DT the) (CD two) (NN hybrid) (NN system)) (CC and) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT2_) (CD _PROT2_))) (PP (IN in) (NP (FW E.) (FW coli)))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (JJ catalytic) (NN subunit))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ many) (JJ cellular) (NNS proteins)) (PP (IN in) (NP (NP (NNS complexes)) (ADJP (RB potentially) (JJ important) (PP (IN for) (NP (PRP$ its) (JJ growth-suppressing) (NN function)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD One) (NN clone)) (VP (VBZ encodes) (NP (NP (NP (DT a) (JJ novel) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ catalytic) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ differs) (PP (IN from) (NP (DT the) (ADJP (RB originally) (VBN defined)) (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (DT an) (JJ amino-terminal) (JJ 11-amino-acid) (NN insert))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD One) (NN clone)) (VP (VBZ encodes) (NP (NP (NP (DT a) (JJ novel) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ catalytic) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ differs) (PP (IN from) (NP (DT the) (ADJP (RB originally) (VBN defined)) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (DT an) (JJ amino-terminal) (JJ 11-amino-acid) (NN insert))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD One) (NN clone)) (VP (VBZ encodes) (NP (NP (NP (DT a) (JJ novel) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_) (JJ catalytic) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ differs) (PP (IN from) (NP (DT the) (ADJP (RB originally) (VBN defined)) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (DT an) (JJ amino-terminal) (JJ 11-amino-acid) (NN insert))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (JJ vitro-binding) (NNS assays))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_) (NNS isoforms)) (ADVP (RB preferentially)) (VP (VBP bind) (NP (NP (DT the) (VBN hypophosphorylated) (NN form)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (JJ similar) (NN _PROT1_) (NNS sequences)) (VP (VBP are) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (JJ similar) (NN _PROT1_) (NNS sequences)) (VP (VBP are) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (JJ similar) (NN _PROT_) (NNS sequences)) (VP (VBP are) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ novel) (NN fold)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN structure)))) (VP (VBZ is) (ADJP (JJ likely) (S (VP (TO to) (VP (VB be) (ADJP (JJ representative) (PP (IN of) (NP (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN /TNF) (NN receptor) (NN family)) (PP (IN as) (NP (DT a) (JJ whole)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NP (NN _PROT1_) (NN binding) (NNS proteins)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NP (NN _PROT1_) (NN binding) (NNS proteins)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NP (NN _PROT_) (NN binding) (NNS proteins)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (, ,) (NP (NN _PROT2_)) (, ,)) (VP (VBZ regulates) (NP (NN cell) (NN proliferation)) (PP (IN by) (S (VP (VP (VBG binding) (PP (TO to))) (CC and) (VP (VBG inhibiting) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (JJ key) (NN growth) (VBG promoting) (NNS proteins)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB now)) (VP (VBN isolated) (NP (NP (NN cDNA) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (DT the) (JJ full-length) (NN coding) (NN sequence)) (PP (IN of) (NP (NP (NP (CD two) (JJ other) (NNS proteins)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,)) (VP (VBN cloned) (ADVP (RB originally)) (PP (IN by) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB now)) (VP (VBN isolated) (NP (NP (NN cDNA) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (DT the) (JJ full-length) (NN coding) (NN sequence)) (PP (IN of) (NP (NP (NP (CD two) (JJ other) (NNS proteins)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBN cloned) (ADVP (RB originally)) (PP (IN by) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB now)) (VP (VBN isolated) (NP (NP (NN cDNA) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (DT the) (JJ full-length) (NN coding) (NN sequence)) (PP (IN of) (NP (NP (NP (CD two) (JJ other) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,)) (VP (VBN cloned) (ADVP (RB originally)) (PP (IN by) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT2_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT2_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT2_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (NP (PRP we)) (VP (VBP have) (VP (VBN been) (ADJP (JJ able) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (ADVP (FW in) (FW vivo)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN dissociated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (VBN purified) (JJ human) (NN papillomavirus) (NN _PROT_) (NN protein))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (NP (PRP we)) (VP (VBP have) (VP (VBN been) (ADJP (JJ able) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (ADVP (FW in) (FW vivo)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN dissociated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (VBN purified) (JJ human) (NN papillomavirus) (NN _PROT2_) (NN protein))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (NP (PRP we)) (VP (VBP have) (VP (VBN been) (ADJP (JJ able) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (ADVP (FW in) (FW vivo)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN dissociated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (VBN purified) (JJ human) (NN papillomavirus) (NN _PROT2_) (NN protein))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NP (JJ vascular) (JJ endothelial) (NN growth) (NN factor)) (NNS determinants)) (PP (IN for) (S (VP (VBG binding) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN receptors.) (NN Generation))) (PP (IN of) (NP (JJ receptor-selective) (NN _PROT_) (NNS variants))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NP (JJ vascular) (JJ endothelial) (NN growth) (NN factor)) (NNS determinants)) (PP (IN for) (S (VP (VBG binding) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)) (NP (NN receptors.) (NN Generation))) (PP (IN of) (NP (JJ receptor-selective) (NN _PROT2_) (NNS variants))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NP (JJ vascular) (JJ endothelial) (NN growth) (NN factor)) (NNS determinants)) (PP (IN for) (S (VP (VBG binding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)) (NP (NN receptors.) (NN Generation))) (PP (IN of) (NP (JJ receptor-selective) (NN _PROT2_) (NNS variants))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN expression)) (PP (IN in) (NP (JJ various) (NN cell) (NNS types)))) (VP (VBZ is) (VP (VBN induced) (PP (IN by) (NP (NP (NN hypoxia)) (CC and) (NP (JJ other) (NNS stimuli))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Alanine-scanning) (NN mutagenesis)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (DT a) (ADJP (RB positively) (JJ charged)) (NN surface)) (PP (IN in) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ mediates) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Alanine-scanning) (NN mutagenesis)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (DT a) (ADJP (RB positively) (JJ charged)) (NN surface)) (PP (IN in) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ mediates) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Alanine-scanning) (NN mutagenesis)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (DT a) (ADJP (RB positively) (JJ charged)) (NN surface)) (PP (IN in) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ mediates) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT1_AND_PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Arg82)) (, ,) (NP (NP (NNP Lys84)) (CC and) (NP (NNP His86))) (, ,) (ADJP (JJ located) (PP (IN in) (NP (DT a) (NN hairpin) (NN loop)))) (, ,)) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT1_AND_PROT2_)))))) (, ,) (SBAR (IN while) (S (NP (NP (ADJP (RB negatively) (JJ charged)) (NNS residues)) (, ,) (NP (NP (NNP Asp63)) (, ,) (NP (NNP Glu64)) (, ,) (CC and) (NP (NNP Glu67))) (, ,)) (VP (VBD were) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_) (NN binding))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Arg82)) (, ,) (NP (NP (NNP Lys84)) (CC and) (NP (NNP His86))) (, ,) (ADJP (JJ located) (PP (IN in) (NP (DT a) (NN hairpin) (NN loop)))) (, ,)) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT1_)))))) (, ,) (SBAR (IN while) (S (NP (NP (ADJP (RB negatively) (JJ charged)) (NNS residues)) (, ,) (NP (NP (NNP Asp63)) (, ,) (NP (NNP Glu64)) (, ,) (CC and) (NP (NNP Glu67))) (, ,)) (VP (VBD were) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_) (NN binding))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Arg82)) (, ,) (NP (NP (NNP Lys84)) (CC and) (NP (NNP His86))) (, ,) (ADJP (JJ located) (PP (IN in) (NP (DT a) (NN hairpin) (NN loop)))) (, ,)) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT1_)))))) (, ,) (SBAR (IN while) (S (NP (NP (ADJP (RB negatively) (JJ charged)) (NNS residues)) (, ,) (NP (NP (NNP Asp63)) (, ,) (NP (NNP Glu64)) (, ,) (CC and) (NP (NNP Glu67))) (, ,)) (VP (VBD were) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_) (NN binding))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN _PROT1_) (NN model)) (VP (VBN based) (PP (IN on) (NP (NN _PROT2_))))) (VP (VBD indicated) (S (NP (DT these) (ADJP (ADVP (ADVP (RB positively)) (CC and) (ADVP (RB negatively))) (JJ charged)) (NNS regions)) (VP (VP (VBP are) (ADJP (JJ distal) (PP (IN in) (NP (DT the) (NN monomer))))) (CC but) (VP (VBP are) (ADJP (RB spatially) (JJ close) (PP (IN in) (NP (DT the) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT2_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT2_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT2_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT1_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT2_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT1_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT2_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT1_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT2_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Endothelial) (NN cell) (NN mitogenesis)) (VP (VBD was) (VP (VBN abolished) (PP (IN in) (NP (NP (NNS mutants)) (VP (VBG lacking) (NP (NN _PROT1_) (NN affinity)))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NN _PROT2_) (JJ deficient) (NNS mutants)) (VP (VBD induced) (NP (JJ normal) (NN proliferation)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (DT this) (JJ mutational) (NN analysis)) (VP (VBZ implicates) (NP (NP (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))) (, ,) (PP (IN in) (NP (NP (NN _PROT_) (NN induction)) (PP (IN of) (NP (JJ endothelial) (NN cell) (NN proliferation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (DT this) (JJ mutational) (NN analysis)) (VP (VBZ implicates) (NP (NP (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_))) (, ,) (PP (IN in) (NP (NP (NN _PROT2_) (NN induction)) (PP (IN of) (NP (JJ endothelial) (NN cell) (NN proliferation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (DT this) (JJ mutational) (NN analysis)) (VP (VBZ implicates) (NP (NP (NN _PROT_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_))) (, ,) (PP (IN in) (NP (NP (NN _PROT2_) (NN induction)) (PP (IN of) (NP (JJ endothelial) (NN cell) (NN proliferation))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN splicing) (NN factor) (NN U2AF)) (PRN (-LRB- -LRB-) (NP (NN U2) (NN snRNP) (NN auxiliary) (NN factor)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (NNS subunits)) (PP (IN of) (NP (NP (NP (CD 65)) (CC and) (NP (CD 35) (NN kD))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (CD 3) ('' ') (NN splice) (NNS sites))))) (, ,) (CC but) (S (NP (JJ previous) (NNS studies)) (VP (VBD failed) (S (VP (TO to) (VP (VB demonstrate) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Nuclear) (NNS extracts)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT1_))))) (VP (VBD were) (ADJP (JJ inactive)))) (: ;) (S (ADVP (RB however)) (, ,) (NP (ADJP (CC both) (ADJP (JJ constitutive)) (CC and) (ADJP (JJ enhancer-dependent))) (NN splicing)) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (VBN purified) (JJ recombinant) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vitro)) (JJ protein-RNA) (NN interaction) (NNS studies)) (PP (IN with) (NP (NP (NNS pre-mRNAs)) (VP (VBG containing) (NP (CC either) (DT a) (ADJP (ADJP (JJ constitutive)) (CC or) (ADJP (JJ regulated))) (NN splicing) (NN enhancer)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ mediates) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NNS proteins))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NNS enhancers)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN bridge)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN enhancer) (NN complex)))))) (S (VP (TO to) (VP (VB recruit) (NP (NN _PROT_)) (PP (TO to) (NP (DT the) (JJ adjacent) (NN intron)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN bridge)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN enhancer) (NN complex)))))) (S (VP (TO to) (VP (VB recruit) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (JJ adjacent) (NN intron)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN bridge)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN enhancer) (NN complex)))))) (S (VP (TO to) (VP (VB recruit) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (JJ adjacent) (NN intron)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (CD _PROT2_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ growth-promoting) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ neoplastic))) (JJ gastrointestinal) (NNS tissues)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ belongs) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (ADJP (NN G) (JJ protein-coupled)) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ growth-promoting) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ neoplastic))) (JJ gastrointestinal) (NNS tissues)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ belongs) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (ADJP (NN G) (JJ protein-coupled)) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ growth-promoting) (NNS effects)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ neoplastic))) (JJ gastrointestinal) (NNS tissues)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ belongs) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (ADJP (NN G) (JJ protein-coupled)) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT1_) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD was) (ADJP (ADJP (JJ rapid)) (CC and) (ADJP (JJ transient))) (, ,) (S (VP (VP (VBG occurring) (PP (IN within) (NP (NP (CD 30) (NN s)) (PP (IN of) (NP (NN treatment)))))) (CC and) (VP (VBG diminishing) (ADVP (RB thereafter))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT2_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT2_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT2_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT1_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT1_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (JJ tyrosine-phosphorylated) (NN _PROT2_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (JJ tyrosine-phosphorylated) (NN _PROT_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (JJ tyrosine-phosphorylated) (NN _PROT1_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT2_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT2_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT2_) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN oncoprotein)))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NP (NN _PROT2_) (NN tumor) (NN suppressor)) (NN transactivation) (NN domain))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN oncoprotein)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN tumor) (NN suppressor))) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (MD can) (VP (VP (VB bind) (NP (NP (DT the) (NN transactivation) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (CC and) (VP (VB downregulate) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB activate) (NP (NN transcription)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN oncoprotein)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN tumor) (NN suppressor))) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (MD can) (VP (VP (VB bind) (NP (NP (DT the) (NN transactivation) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (CC and) (VP (VB downregulate) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB activate) (NP (NN transcription)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN oncoprotein)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN tumor) (NN suppressor))) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (MD can) (VP (VP (VB bind) (NP (NP (DT the) (NN transactivation) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (CC and) (VP (VB downregulate) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB activate) (NP (NN transcription)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (JJ certain) (NNS cancers))) (, ,) (NP (NN _PROT1_) (NN amplification)) (VP (VP (VBZ is) (NP (DT a) (JJ common) (NN event))) (CC and) (VP (VBZ contributes) (PP (TO to) (NP (NP (DT the) (NN inactivation)) (PP (IN of) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT2_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT2_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT1_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT1_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT2_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT2_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT1_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT1_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT2_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT1_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT2_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT2_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT2_) (NN cleft))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT1_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT2_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (JJ same) (NN _PROT1_) (NNS residues)) (VP (VBP are) (ADVP (RB also)) (VP (VBN involved) (PP (IN in) (NP (NN transactivation))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ inactivates) (NP (NN _PROT_)) (PP (IN by) (NP (NN concealing) (PRP$ its) (NN transactivation) (NN domain)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (JJ same) (NN _PROT1_) (NNS residues)) (VP (VBP are) (ADVP (RB also)) (VP (VBN involved) (PP (IN in) (NP (NN transactivation))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inactivates) (NP (NN _PROT2_)) (PP (IN by) (NP (NN concealing) (PRP$ its) (NN transactivation) (NN domain)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (JJ same) (NN _PROT_) (NNS residues)) (VP (VBP are) (ADVP (RB also)) (VP (VBN involved) (PP (IN in) (NP (NN transactivation))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inactivates) (NP (NN _PROT2_)) (PP (IN by) (NP (NN concealing) (PRP$ its) (NN transactivation) (NN domain)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Lipopolysaccharide-activated) (JJ _PROT1_) (-LRB- -LRB-) (JJ ICE-/-) (-RRB- -RRB-) (NN Kupffer) (NNS cells)) (VP (VP (VBD synthesized) (NP (DT the) (NN _PROT2_) (NN precursor))) (CC but) (VP (VBD failed) (S (VP (TO to) (VP (VB process) (NP (PRP it)) (PP (IN into) (NP (DT the) (JJ active) (NN form))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN diminished) (PP (IN in) (NP (NP (DT the) (NN sera)) (PP (IN of) (NP (NP (JJ _PROT_) (NNS mice)) (VP (VBN exposed) (PP (TO to) (NP (NP (NN Propionibacterium) (NNS acnes)) (CC and) (NP (NN lipopolysaccharide)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN diminished) (PP (IN in) (NP (NP (DT the) (NN sera)) (PP (IN of) (NP (NP (JJ _PROT2_) (NNS mice)) (VP (VBN exposed) (PP (TO to) (NP (NP (NN Propionibacterium) (NNS acnes)) (CC and) (NP (NN lipopolysaccharide)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (VP (VBN diminished) (PP (IN in) (NP (NP (DT the) (NN sera)) (PP (IN of) (NP (NP (JJ _PROT2_) (NNS mice)) (VP (VBN exposed) (PP (TO to) (NP (NP (NN Propionibacterium) (NNS acnes)) (CC and) (NP (NN lipopolysaccharide)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Through) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN ErbB) (NN family)) (PP (IN of) (NP (NP (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)))))))) (, ,) (NP (NNS neuregulins)) (VP (VB help) (S (VP (TO to) (VP (VB regulate) (NP (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN in) (NP (JJ many) (NNS tissues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Through) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN ErbB) (NN family)) (PP (IN of) (NP (NP (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))) (, ,) (NP (NNS neuregulins)) (VP (VB help) (S (VP (TO to) (VP (VB regulate) (NP (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN in) (NP (JJ many) (NNS tissues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Through) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN ErbB) (NN family)) (PP (IN of) (NP (NP (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))) (, ,) (NP (NNS neuregulins)) (VP (VB help) (S (VP (TO to) (VP (VB regulate) (NP (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN in) (NP (JJ many) (NNS tissues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN encoded) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene)))) (VP (VBZ has) (NP (NP (DT a) (NN motif) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (PP (IN of) (NP (NNS neuregulins))))))))) (CC and) (S (NP (NP (DT an) (JJ alternative) (NN splicing) (NN site)) (PP (IN in) (NP (DT the) (ADJP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -like)) (NN domain)))) (VP (VBZ gives) (NP (NN rise)) (PP (TO to) (NP (NP (CD two) (NNS isoforms)) (PRN (-LRB- -LRB-) (NP (NP (NN alpha)) (CC and) (NP (NN beta))) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN encoded) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene)))) (VP (VBZ has) (NP (NP (DT a) (NN motif) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (PP (IN of) (NP (NNS neuregulins))))))))) (CC and) (S (NP (NP (DT an) (JJ alternative) (NN splicing) (NN site)) (PP (IN in) (NP (DT the) (ADJP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -like)) (NN domain)))) (VP (VBZ gives) (NP (NN rise)) (PP (TO to) (NP (NP (CD two) (NNS isoforms)) (PRN (-LRB- -LRB-) (NP (NP (NN alpha)) (CC and) (NP (NN beta))) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN encoded) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene)))) (VP (VBZ has) (NP (NP (DT a) (NN motif) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (PP (IN of) (NP (NNS neuregulins))))))))) (CC and) (S (NP (NP (DT an) (JJ alternative) (NN splicing) (NN site)) (PP (IN in) (NP (DT the) (ADJP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -like)) (NN domain)))) (VP (VBZ gives) (NP (NN rise)) (PP (TO to) (NP (NP (CD two) (NNS isoforms)) (PRN (-LRB- -LRB-) (NP (NP (NN alpha)) (CC and) (NP (NN beta))) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT2_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT2_))) (NN _PROT_) (NN surface) (NN expression)) (VP (VBZ correlates) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT an) (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN peptide))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT_))) (NN _PROT2_) (NN surface) (NN expression)) (VP (VBZ correlates) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT an) (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN peptide))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ _PROT1_))) (NN _PROT2_) (NN surface) (NN expression)) (VP (VBZ correlates) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT an) (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN peptide))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_) (NN surface) (NN expression)) (VP (VBZ is) (VP (VBN correlated) (PP (IN with) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NN MHC) (NN class) (NN I) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VBP provide) (NP (NP (JJ suitable) (NN leader) (NN sequence) (NNS peptides)) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (VP (VBN _PROT2_) (PP (IN _PROT2_) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (VP (VBN _PROT2_) (PP (IN _PROT2_) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT1_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBZ dissociates) (PP (IN from) (NP (NN _PROT2_))) (PP (IN upon) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN sequence) (NNS peptides))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN MHC) (NN class) (CD I)) (NN surface) (NN expression))))) (VP (MD might) (VP (VB be) (ADJP (JJ relevant) (PP (TO to) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (, ,) (SBAR (IN although) (S (NP (DT these) (JJ _PROT1_) (NN binding) (NNS peptides)) (VP (VBP are) (VP (VBN derived) (PP (IN from) (NP (NN signal) (NNS sequences))))))) (, ,) (NP (PRP they)) (VP (MD may) (VP (VB be) (VP (VP (VBN released) (ADVP (RB back)) (PP (IN into) (NP (DT the) (NN cytosol)))) (CC and) (VP (ADVP (RB subsequently)) (VBN translocated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBN loaded) (PP (IN onto) (NP (JJ _PROT_) (NNS molecules))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (, ,) (SBAR (IN although) (S (NP (DT these) (JJ _PROT1_) (NN binding) (NNS peptides)) (VP (VBP are) (VP (VBN derived) (PP (IN from) (NP (NN signal) (NNS sequences))))))) (, ,) (NP (PRP they)) (VP (MD may) (VP (VB be) (VP (VP (VBN released) (ADVP (RB back)) (PP (IN into) (NP (DT the) (NN cytosol)))) (CC and) (VP (ADVP (RB subsequently)) (VBN translocated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN complex)))) (CC and) (VP (VBN loaded) (PP (IN onto) (NP (JJ _PROT2_) (NNS molecules))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (, ,) (SBAR (IN although) (S (NP (DT these) (JJ _PROT_) (NN binding) (NNS peptides)) (VP (VBP are) (VP (VBN derived) (PP (IN from) (NP (NN signal) (NNS sequences))))))) (, ,) (NP (PRP they)) (VP (MD may) (VP (VB be) (VP (VP (VBN released) (ADVP (RB back)) (PP (IN into) (NP (DT the) (NN cytosol)))) (CC and) (VP (ADVP (RB subsequently)) (VBN translocated) (PP (IN by) (NP (DT the) (NN _PROT1_) (NN complex)))) (CC and) (VP (VBN loaded) (PP (IN onto) (NP (JJ _PROT2_) (NNS molecules))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NP (JJ calcium-stimulated) (NN _PROT1_) (NN release)) (PP (IN from) (NP (NN gastrinoma) (NNS cells)))))) (ADVP (FW in) (FW vitro)) (PP (IN with) (NP (NP (DT a) (JJ particular) (NN focus)) (PP (IN on) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NP (JJ calcium-stimulated) (NN _PROT1_) (NN release)) (PP (IN from) (NP (NN gastrinoma) (NNS cells)))))) (ADVP (FW in) (FW vitro)) (PP (IN with) (NP (NP (DT a) (JJ particular) (NN focus)) (PP (IN on) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NP (JJ calcium-stimulated) (NN _PROT_) (NN release)) (PP (IN from) (NP (NN gastrinoma) (NNS cells)))))) (ADVP (FW in) (FW vitro)) (PP (IN with) (NP (NP (DT a) (JJ particular) (NN focus)) (PP (IN on) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBD was) (VP (VBN expressed) (PP (IN in) (NP (JJ human) (NN gastrinoma) (NNS cells))))) (CC and) (VP (MD could) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (JJ calcium-evoked) (NN _PROT2_) (NN release))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NN dopamine) (JJ synthetic) (NNS enzymes)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (NN enzyme)) (ADJP (JJ critical) (PP (IN for) (NP (NN tetrahydrobiopterin) (NN synthesis)))))) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN contransduced) (PP (IN into) (NP (CD 293) (NNS cells))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Expressions)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (NN Western) (NN blot) (NN analysis)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Expressions)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (NN Western) (NN blot) (NN analysis)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Expressions)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (NN Western) (NN blot) (NN analysis)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB effectively)) (VP (VBN coexpressed) (PP (IN in) (NP (VBN transduced) (NNS cells))) (PP (IN with) (NP (NP (CD three) (JJ separate) (NN AAV) (NNS vectors)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NP (DT The) (JJ triple) (NN transduction)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NNS genes)))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))) (VP (VBZ is) (ADJP (JJ effective)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD might) (VP (VB be) (ADJP (JJ important) (PP (TO to) (NP (NP (NN gene) (NN therapy)) (PP (IN for) (NP (NP (NN Parkinson) (POS 's)) (NN disease)))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NP (DT The) (JJ triple) (NN transduction)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NNS genes)))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))) (VP (VBZ is) (ADJP (JJ effective)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD might) (VP (VB be) (ADJP (JJ important) (PP (TO to) (NP (NP (NN gene) (NN therapy)) (PP (IN for) (NP (NP (NN Parkinson) (POS 's)) (NN disease)))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NP (DT The) (JJ triple) (NN transduction)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NNS genes)))) (PP (IN with) (NP (JJ separate) (NN AAV) (NNS vectors)))) (VP (VBZ is) (ADJP (JJ effective)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD might) (VP (VB be) (ADJP (JJ important) (PP (TO to) (NP (NP (NN gene) (NN therapy)) (PP (IN for) (NP (NP (NN Parkinson) (POS 's)) (NN disease)))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Cytokines) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNP Immunotech) (, ,) (NNP France)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NNS _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN sP-)) (CC and) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN R&D)) (, ,) (NP (NN UK)) (-RRB- -RRB-))))) (VP (VBP have) (VP (VBN been) (VP (VBN determined) (S (VP (VBG using) (NP (NP (NN ELISA) (NNS kits)) (PRN (-LRB- -LRB-) (NP (NP (NN photometer)) (, ,) (NP (NN Biomek-1000)) (, ,) (NP (NN Beckman)) (, ,) (NP (NN USA))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN sP-)) (CC and) (NP (NN _PROT2_)))) (NNS levels)) (VP (VBD were) (RB not) (ADJP (JJ related) (PP (TO to) (NP (NP (NN function)) (PP (IN of) (NP (NP (NNS lymphocytes)) (PRN (-LRB- -LRB-) (PP (IN by) (NP (NN MDM) (NNS data))) (-RRB- -RRB-))))))) (SBAR (IN as) (S (S (VP (VBN seen) (PP (IN in) (NP (DT both) (NNS tests))))) (: ;) (S (NP (PRP it)) (VP (VBZ is) (ADJP (JJ probable)) (SBAR (IN that) (S (NP (DT another) (JJ cell-cell) (NN communication) (NN mechanism)) (VP (VBD had) (VP (VBN been) (VP (VBN switched) (PRT (IN on))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD established) (NP (NP (DT a) (JJ strong) (NN correlation)) (PP (IN between) (NP (NP (NP (NN chromatin) (NN activity)) (PP (IN of) (NP (NNS lymphocytes)))) (CC and) (NP (NP (DT the) (NN serum) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (NP (NP (DT the) (JJ active) (NNS participants)) (PP (IN in) (NP (NP (DT the) (ADJP (ADJP (JJ pro-)) (CC and) (ADJP (JJ anti-inflammatory))) (NN program)) (PP (IN in) (NP (NN atherogenesis))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD established) (NP (NP (DT a) (JJ strong) (NN correlation)) (PP (IN between) (NP (NP (NP (NN chromatin) (NN activity)) (PP (IN of) (NP (NNS lymphocytes)))) (CC and) (NP (NP (DT the) (NN serum) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (NP (NP (DT the) (JJ active) (NNS participants)) (PP (IN in) (NP (NP (DT the) (ADJP (ADJP (JJ pro-)) (CC and) (ADJP (JJ anti-inflammatory))) (NN program)) (PP (IN in) (NP (NN atherogenesis))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD established) (NP (NP (DT a) (JJ strong) (NN correlation)) (PP (IN between) (NP (NP (NP (NN chromatin) (NN activity)) (PP (IN of) (NP (NNS lymphocytes)))) (CC and) (NP (NP (DT the) (NN serum) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (NP (NP (DT the) (JJ active) (NNS participants)) (PP (IN in) (NP (NP (DT the) (ADJP (ADJP (JJ pro-)) (CC and) (ADJP (JJ anti-inflammatory))) (NN program)) (PP (IN in) (NP (NN atherogenesis))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (NN _PROT2_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ Shared)) (CC and) (ADJP (JJ unique))) (NNS determinants)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT1_) (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (NN Phe93)) (PP (IN in) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ is) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (NN Phe93))) (PP (IN with) (NP (NP (NN alanine)) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ dramatic) (NN decrease)) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NP (DT the) (ADJP (FW Escherichia) (JJ coli-expressed)) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (CC and) (NP (NP (DT no) (JJ detectable) (NN binding)) (PP (TO to) (NP (NP (JJ full-length) (JJ mutant) (NN receptor)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells)))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Remarkably)) (, ,) (NP (NN Phe93)) (VP (VBZ forms) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (DT a) (NN peptide) (NN ligand)) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_)) (VP (VBN bound) (PP (TO to) (NP (NP (DT an) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN alanine) (NN substitution)) (PP (IN of) (NP (NP (JJ _PROT1_) (NNS residues)) (PP (IN that) (NP (NN contact) (NN _PROT2_))))) (PP (IN in) (NP (DT the) (NN crystal) (NN structure)))) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (DT these) (NNS residues))) (PP (IN in) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN alanine) (NN substitution)) (PP (IN of) (NP (NP (JJ _PROT1_) (NNS residues)) (PP (IN that) (NP (NN contact) (NN _PROT_))))) (PP (IN in) (NP (DT the) (NN crystal) (NN structure)))) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (DT these) (NNS residues))) (PP (IN in) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN alanine) (NN substitution)) (PP (IN of) (NP (NP (JJ _PROT1_) (NNS residues)) (PP (IN that) (NP (NN contact) (NN _PROT_))))) (PP (IN in) (NP (DT the) (NN crystal) (NN structure)))) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (DT these) (NNS residues))) (PP (IN in) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN alanine) (NN substitution)) (PP (IN of) (NP (NP (JJ _PROT_) (NNS residues)) (PP (IN that) (NP (NN contact) (NN _PROT1_))))) (PP (IN in) (NP (DT the) (NN crystal) (NN structure)))) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (DT these) (NNS residues))) (PP (IN in) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN alanine) (NN substitution)) (PP (IN of) (NP (NP (JJ _PROT_) (NNS residues)) (PP (IN that) (NP (NN contact) (NN _PROT1_))))) (PP (IN in) (NP (DT the) (NN crystal) (NN structure)))) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (DT these) (NNS residues))) (PP (IN in) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (NN alanine) (NN substitution)) (PP (IN of) (NP (NP (JJ _PROT_) (NNS residues)) (PP (IN that) (NP (NN contact) (NN _PROT_))))) (PP (IN in) (NP (DT the) (NN crystal) (NN structure)))) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (DT these) (NNS residues))) (PP (IN in) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN binding)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NN binding)))))) (, ,) (S (NP (NN Met150)) (VP (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding))))) (CC but) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT_) (NN binding))))))) (, ,) (CC and) (S (NP (NN Thr151)) (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NP (NN binding)) (CC either) (NP (NN ligand))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NN binding)))))) (, ,) (S (NP (NN Met150)) (VP (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT2_) (NN binding))))) (CC but) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT_) (NN binding))))))) (, ,) (CC and) (S (NP (NN Thr151)) (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NP (NN binding)) (CC either) (NP (NN ligand))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NN binding)))))) (, ,) (S (NP (NN Met150)) (VP (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding))))) (CC but) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT2_) (NN binding))))))) (, ,) (CC and) (S (NP (NN Thr151)) (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NP (NN binding)) (CC either) (NP (NN ligand))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (NP (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NN binding)))))) (, ,) (S (NP (NN Met150)) (VP (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT2_) (NN binding))))) (CC but) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT_) (NN binding))))))) (, ,) (CC and) (S (NP (NN Thr151)) (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NP (NN binding)) (CC either) (NP (NN ligand))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (NP (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NN binding)))))) (, ,) (S (NP (NN Met150)) (VP (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT_) (NN binding))))) (CC but) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT2_) (NN binding))))))) (, ,) (CC and) (S (NP (NN Thr151)) (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NP (NN binding)) (CC either) (NP (NN ligand))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (ADJP (JJ important) (PP (IN for) (NP (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NN binding)))))) (, ,) (S (NP (NN Met150)) (VP (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NN _PROT1_) (NN binding))))) (CC but) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT2_) (NN binding))))))) (, ,) (CC and) (S (NP (NN Thr151)) (VP (VBZ is) (RB not) (ADJP (JJ important) (PP (IN for) (NP (NP (NN binding)) (CC either) (NP (NN ligand))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (NP (NP (JJ important) (NN binding) (NNS determinants)) (PP (IN for) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (SBAR (RB even) (IN though) (S (NP (DT these) (NNS ligands)) (VP (VBP share) (NP (DT no) (NN sequence) (CC or) (JJ structural) (NN homology)) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (DT these) (NNS residues)) (VP (MD may) (VP (VB represent) (NP (NP (DT a) (JJ minimum) (NN epitope)) (PP (IN on) (NP (DT the) (NN _PROT_))) (PP (IN for) (NP (JJ productive) (NN ligand) (NN binding))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (NP (NP (JJ important) (NN binding) (NNS determinants)) (PP (IN for) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (SBAR (RB even) (IN though) (S (NP (DT these) (NNS ligands)) (VP (VBP share) (NP (DT no) (NN sequence) (CC or) (JJ structural) (NN homology)) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (DT these) (NNS residues)) (VP (MD may) (VP (VB represent) (NP (NP (DT a) (JJ minimum) (NN epitope)) (PP (IN on) (NP (DT the) (NN _PROT2_))) (PP (IN for) (NP (JJ productive) (NN ligand) (NN binding))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NNP Phe93)) (CC and) (NP (NNP Phe205))) (VP (VBP are) (NP (NP (JJ important) (NN binding) (NNS determinants)) (PP (IN for) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (SBAR (RB even) (IN though) (S (NP (DT these) (NNS ligands)) (VP (VBP share) (NP (DT no) (NN sequence) (CC or) (JJ structural) (NN homology)) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (DT these) (NNS residues)) (VP (MD may) (VP (VB represent) (NP (NP (DT a) (JJ minimum) (NN epitope)) (PP (IN on) (NP (DT the) (NN _PROT2_))) (PP (IN for) (NP (JJ productive) (NN ligand) (NN binding))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN crystallized) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (NP (DT a) (JJ two-domain) (JJ extracellular) (NN fragment)) (PP (IN of) (NP (JJ human) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN cDNA) (NN clone)) (VP (VBG encoding) (NP (NP (NP (DT a) (ADJP (ADJP (JJ novel)) (, ,) (ADJP (RB widely) (VBN expressed))) (NN protein)) (PRN (-LRB- -LRB-) (NP (NP (VBN called) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (CD one) (NN src) (NN homology) (CD 2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN domain)) (CC and) (NP (CD two) (NN SH3) (NNS domains))))))) (VP (VBD was) (VP (VBN isolated)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN While) (S (NP (NP (NN injection)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (NNS proteins)) (ADVP (RB alone)))) (PP (IN into) (NP (JJ quiescent) (NN rat) (NNS fibroblasts)))) (VP (VBD did) (RB not) (VP (VB have) (NP (JJ mitogenic) (NN effect)))))) (, ,) (NP (NP (NN microinjection)) (PP (IN of) (NP (NN _PROT_))) (PP (ADVP (RB together)) (IN with) (NP (NN _PROT_) (NN protein)))) (VP (VBD stimulated) (NP (NN DNA) (NN synthesis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN While) (S (NP (NP (NN injection)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (NNS proteins)) (ADVP (RB alone)))) (PP (IN into) (NP (JJ quiescent) (NN rat) (NNS fibroblasts)))) (VP (VBD did) (RB not) (VP (VB have) (NP (JJ mitogenic) (NN effect)))))) (, ,) (NP (NP (NN microinjection)) (PP (IN of) (NP (NN _PROT2_))) (PP (ADVP (RB together)) (IN with) (NP (NN _PROT_) (NN protein)))) (VP (VBD stimulated) (NP (NN DNA) (NN synthesis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN While) (S (NP (NP (NN injection)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (NNS proteins)) (ADVP (RB alone)))) (PP (IN into) (NP (JJ quiescent) (NN rat) (NNS fibroblasts)))) (VP (VBD did) (RB not) (VP (VB have) (NP (JJ mitogenic) (NN effect)))))) (, ,) (NP (NP (NN microinjection)) (PP (IN of) (NP (NN _PROT_))) (PP (ADVP (RB together)) (IN with) (NP (NN _PROT2_) (NN protein)))) (VP (VBD stimulated) (NP (NN DNA) (NN synthesis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN While) (S (NP (NP (NN injection)) (PP (IN of) (NP (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (NNS proteins)) (ADVP (RB alone)))) (PP (IN into) (NP (JJ quiescent) (NN rat) (NNS fibroblasts)))) (VP (VBD did) (RB not) (VP (VB have) (NP (JJ mitogenic) (NN effect)))))) (, ,) (NP (NP (NN microinjection)) (PP (IN of) (NP (NN _PROT2_))) (PP (ADVP (RB together)) (IN with) (NP (NN _PROT_) (NN protein)))) (VP (VBD stimulated) (NP (NN DNA) (NN synthesis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN While) (S (NP (NP (NN injection)) (PP (IN of) (NP (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (NNS proteins)) (ADVP (RB alone)))) (PP (IN into) (NP (JJ quiescent) (NN rat) (NNS fibroblasts)))) (VP (VBD did) (RB not) (VP (VB have) (NP (JJ mitogenic) (NN effect)))))) (, ,) (NP (NP (NN microinjection)) (PP (IN of) (NP (NN _PROT_))) (PP (ADVP (RB together)) (IN with) (NP (NN _PROT2_) (NN protein)))) (VP (VBD stimulated) (NP (NN DNA) (NN synthesis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN While) (S (NP (NP (NN injection)) (PP (IN of) (NP (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (NNS proteins)) (ADVP (RB alone)))) (PP (IN into) (NP (JJ quiescent) (NN rat) (NNS fibroblasts)))) (VP (VBD did) (RB not) (VP (VB have) (NP (JJ mitogenic) (NN effect)))))) (, ,) (NP (NP (NN microinjection)) (PP (IN of) (NP (NN _PROT1_))) (PP (ADVP (RB together)) (IN with) (NP (NN _PROT2_) (NN protein)))) (VP (VBD stimulated) (NP (NN DNA) (NN synthesis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_AND_PROT2_)) (VP (VBZ plays) (NP (DT a) (JJ crucial) (NN role)) (PP (IN in) (NP (NP (DT a) (ADJP (RB highly) (VBN conserved)) (NN mechanism)) (PP (IN for) (NP (NP (NN growth) (NN factor) (NN control)) (PP (IN of) (NP (NN ras) (NN signaling)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN expression) (NN plasmid)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (JJ 75-kDa) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB generate) (NP (NP (NP (DT a) (JJ stable) (JJ human) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG overexpressing) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN expression) (NN plasmid)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (JJ 75-kDa) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB generate) (NP (NP (NP (DT a) (JJ stable) (JJ human) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG overexpressing) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN expression) (NN plasmid)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (JJ 75-kDa) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB generate) (NP (NP (NP (DT a) (JJ stable) (JJ human) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG overexpressing) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN expression) (NN plasmid)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (JJ 75-kDa) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB generate) (NP (NP (NP (DT a) (JJ stable) (JJ human) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG overexpressing) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN expression) (NN plasmid)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (JJ 75-kDa) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB generate) (NP (NP (NP (DT a) (JJ stable) (JJ human) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG overexpressing) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN expression) (NN plasmid)) (VP (VBG encoding) (NP (NP (DT the) (JJ human) (JJ 75-kDa) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB generate) (NP (NP (NP (DT a) (JJ stable) (JJ human) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBG overexpressing) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Ligand) (NN binding) (NN analysis)) (VP (VBD revealed) (NP (NP (JJ high) (NN affinity) (NN binding)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 0.2) (NN nM)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (QP (RB approximately) (CD 94,000) (CC +/-) (CD 7,500)) (NNS sites/cell)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (ADJP (ADVP (RB approximately) (RB 5-fold)) (JJR lower)) (NN affinity)) (PP (IN for) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 1.1) (NN nM)) (-RRB- -RRB-))))))) (PP (IN with) (NP (QP (CD 264,000) (CC +/-) (CD 2,000)) (NNS sites/cell))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT2_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT2_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT2_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT2_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT1_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT1_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT1_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT2_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT2_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cross-linking)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_) (NNS cells)))) (VP (VBD yielded) (NP (NP (JJ predominant) (NNS complexes)) (PP (IN with) (NP (NP (JJ apparent) (JJ molecular) (NNS weights)) (PP (IN of) (NP (NP (NP (CD 211,000)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN 205,000))))) (CC and) (NP (NP (CD 244,000)) (PP (IN for) (NP (NN _PROT1_))))))))) (, ,) (S (VP (VBG suggesting) (S (NP (DT these) (NNS complexes)) (VP (VBP contain) (NP (QP (CD two) (CC or) (CD three)) (NN _PROT2_) (NNS molecules)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN from) (NP (JJ 32P-labeled) (NN _PROT2_) (NNS cells)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (DT the) (NN receptor)) (VP (VBZ is) (VP (VBN phosphorylated))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (NN _PROT2_) (NNS cells)))) (VP (VBD did) (RB not) (ADVP (RB significantly)) (VP (VB affect) (NP (NP (DT the) (NP (NN degree)) (CC or) (NP (NN pattern))) (PP (IN of) (NP (NN phosphorylation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Shedding)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD was) (VP (VBN induced) (PP (PP (IN by) (NP (CD 4) (NN beta-phorbol) (NN 12-myristate) (NN 13-acetate))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Shedding)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD was) (VP (VBN induced) (PP (PP (IN by) (NP (CD 4) (NN beta-phorbol) (NN 12-myristate) (NN 13-acetate))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Shedding)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD was) (VP (VBN induced) (PP (PP (IN by) (NP (CD 4) (NN beta-phorbol) (NN 12-myristate) (NN 13-acetate))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD Two) (ADJP (RB previously) (JJ unidentified)) (JJ human) (NN _PROT1_) (NNS genes)) (VP (VBP have) (VP (VBN been) (VP (VBN isolated) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD Two) (ADJP (RB previously) (JJ unidentified)) (JJ human) (NN _PROT1_) (NNS genes)) (VP (VBP have) (VP (VBN been) (VP (VBN isolated) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD Two) (ADJP (RB previously) (JJ unidentified)) (JJ human) (NN _PROT_) (NNS genes)) (VP (VBP have) (VP (VBN been) (VP (VBN isolated) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Microinjection)) (PP (IN of) (NP (NN _PROT1_) (NNS antibodies))) (PP (IN into) (NP (NN HeLa) (NNS cells)))) (VP (VBZ causes) (NP (PRP$ their) (NN arrest)) (PP (IN in) (S (VP (VBG mitosis.) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP display) (NP (NP (NP (JJ endogenous) (NN tyrosine) (NN phosphatase)) (NN activity)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN stimulated) (ADVP (RB several-fold)) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cdc2))))) (, ,) (PP (IN by) (NP (NP (JJ stoichiometric) (NN addition)) (PP (IN of) (NP (CC either) (NP (NN _PROT_) (NN _PROT_)) (CC or) (NP (NN B2)) (CONJP (CC but) (RB not)) (NP (NP (NN A)) (CC or) (NP (NN D1)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Microinjection)) (PP (IN of) (NP (NN _PROT1_) (NNS antibodies))) (PP (IN into) (NP (NN HeLa) (NNS cells)))) (VP (VBZ causes) (NP (PRP$ their) (NN arrest)) (PP (IN in) (S (VP (VBG mitosis.) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP display) (NP (NP (NP (JJ endogenous) (NN tyrosine) (NN phosphatase)) (NN activity)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN stimulated) (ADVP (RB several-fold)) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cdc2))))) (, ,) (PP (IN by) (NP (NP (JJ stoichiometric) (NN addition)) (PP (IN of) (NP (CC either) (NP (NN _PROT_) (NN _PROT_)) (CC or) (NP (NN B2)) (CONJP (CC but) (RB not)) (NP (NP (NN A)) (CC or) (NP (NN D1)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Microinjection)) (PP (IN of) (NP (NN _PROT1_) (NNS antibodies))) (PP (IN into) (NP (NN HeLa) (NNS cells)))) (VP (VBZ causes) (NP (PRP$ their) (NN arrest)) (PP (IN in) (S (VP (VBG mitosis.) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP display) (NP (NP (NP (JJ endogenous) (NN tyrosine) (NN phosphatase)) (NN activity)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN stimulated) (ADVP (RB several-fold)) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cdc2))))) (, ,) (PP (IN by) (NP (NP (JJ stoichiometric) (NN addition)) (PP (IN of) (NP (CC either) (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN B2)) (CONJP (CC but) (RB not)) (NP (NP (NN A)) (CC or) (NP (NN D1)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Microinjection)) (PP (IN of) (NP (NN _PROT_) (NNS antibodies))) (PP (IN into) (NP (NN HeLa) (NNS cells)))) (VP (VBZ causes) (NP (PRP$ their) (NN arrest)) (PP (IN in) (S (VP (VBG mitosis.) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP display) (NP (NP (NP (JJ endogenous) (NN tyrosine) (NN phosphatase)) (NN activity)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN stimulated) (ADVP (RB several-fold)) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cdc2))))) (, ,) (PP (IN by) (NP (NP (JJ stoichiometric) (NN addition)) (PP (IN of) (NP (CC either) (NP (NN _PROT_) (NN _PROT_)) (CC or) (NP (NN B2)) (CONJP (CC but) (RB not)) (NP (NP (NN A)) (CC or) (NP (NN D1)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Microinjection)) (PP (IN of) (NP (NN _PROT_) (NNS antibodies))) (PP (IN into) (NP (NN HeLa) (NNS cells)))) (VP (VBZ causes) (NP (PRP$ their) (NN arrest)) (PP (IN in) (S (VP (VBG mitosis.) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP display) (NP (NP (NP (JJ endogenous) (NN tyrosine) (NN phosphatase)) (NN activity)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN stimulated) (ADVP (RB several-fold)) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cdc2))))) (, ,) (PP (IN by) (NP (NP (JJ stoichiometric) (NN addition)) (PP (IN of) (NP (CC either) (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN B2)) (CONJP (CC but) (RB not)) (NP (NP (NN A)) (CC or) (NP (NN D1)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Microinjection)) (PP (IN of) (NP (NN _PROT_) (NNS antibodies))) (PP (IN into) (NP (NN HeLa) (NNS cells)))) (VP (VBZ causes) (NP (PRP$ their) (NN arrest)) (PP (IN in) (S (VP (VBG mitosis.) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP display) (NP (NP (NP (JJ endogenous) (NN tyrosine) (NN phosphatase)) (NN activity)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN stimulated) (ADVP (RB several-fold)) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cdc2))))) (, ,) (PP (IN by) (NP (NP (JJ stoichiometric) (NN addition)) (PP (IN of) (NP (CC either) (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN B2)) (CONJP (CC but) (RB not)) (NP (NP (NN A)) (CC or) (NP (NN D1)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (DT the) (NN HeLa) (NNS cells)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT2_))))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (DT the) (NN HeLa) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_))))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (DT the) (NN HeLa) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN B-type) (NNS cyclins)) (VP (VBP are) (NP (NP (JJ multifunctional) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (CONJP (RB not) (RB only)) (VP (VBP act) (PP (IN as) (NP (NP (NN M) (NN phase) (NP (JJ regulatory) (NNS subunits))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein) (NN kinase)))))) (, ,) (CONJP (CC but) (RB also)) (VP (VBP activate) (NP (NP (DT the) (NN _PROT2_) (NN tyrosine) (NN phosphatase)) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (DT the) (JJ physiological) (NN substrate)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN B-type) (NNS cyclins)) (VP (VBP are) (NP (NP (JJ multifunctional) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (CONJP (RB not) (RB only)) (VP (VBP act) (PP (IN as) (NP (NP (NN M) (NN phase) (NP (JJ regulatory) (NNS subunits))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein) (NN kinase)))))) (, ,) (CONJP (CC but) (RB also)) (VP (VBP activate) (NP (NP (DT the) (NN _PROT_) (NN tyrosine) (NN phosphatase)) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (DT the) (JJ physiological) (NN substrate)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN B-type) (NNS cyclins)) (VP (VBP are) (NP (NP (JJ multifunctional) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (CONJP (RB not) (RB only)) (VP (VBP act) (PP (IN as) (NP (NP (NN M) (NN phase) (NP (JJ regulatory) (NNS subunits))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein) (NN kinase)))))) (, ,) (CONJP (CC but) (RB also)) (VP (VBP activate) (NP (NP (DT the) (NN _PROT1_) (NN tyrosine) (NN phosphatase)) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (DT the) (JJ physiological) (NN substrate)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN motif)) (VP (MD may) (VP (VB represent) (NP (NP (DT an) (NN activating) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (S (VP (TO to) (VP (VB be) (VP (VBN provided) (PP (TO to) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (JJ intermolecular) (NN interaction)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (JJ rational) (NN mutagenesis)) (, ,) (NP (JJ receptor-specific) (JJ functional) (NN analysis)) (, ,) (CC and) (NP (NP (NN visualization)) (PP (IN of) (NP (NN complex) (NN formation))) (PP (IN in) (NP (NN solution)))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (JJ individual) (NN amino) (NN acid) (JJ side) (NNS chains)) (VP (VBN involved) (ADVP (RB specifically)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (CC and) (PP (RB not) (IN with) (NP (NP (DT the) (NNS beta-components)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Superposition)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN growth) (NN hormone))) (NNS structures)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN location)) (PP (IN of) (NP (DT these) (NNS epitopes))) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBZ is) (ADJP (JJ analogous) (PP (TO to) (NP (NP (DT the) (NN location)) (PP (IN of) (NP (NP (DT the) (ADJP (ADJP (JJ first)) (CC and) (ADJP (JJ second))) (NN receptor) (NNS epitopes)) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN growth) (NN hormone))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NNS Eosinophils)) (VP (VP (VBP undergo) (NP (NN chemotaxis))) (, ,) (VP (VB degranulate)) (, ,) (CC and) (VP (VBP exhibit) (NP (NP (JJ [C2+) (-RRB- -RSB-) (NN i) (NNS changes)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (DT the) (JJ human) (NN CC) (NNS chemokines)) (NP (NP (NN macrophage) (JJ inflammatory) (NN protein) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN regulated) (PP (IN on) (NP (NP (NN activation)) (, ,) (NP (NP (NP (JJ normal) (NN T)) (VP (VP (VBN expressed)) (CC and) (VP (VBN secreted)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (NNS receptors)) (VP (VBN involved))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN defined)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NNS Eosinophils)) (VP (VP (VBP undergo) (NP (NN chemotaxis))) (, ,) (VP (VB degranulate)) (, ,) (CC and) (VP (VBP exhibit) (NP (NP (JJ [C2+) (-RRB- -RSB-) (NN i) (NNS changes)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (DT the) (JJ human) (NN CC) (NNS chemokines)) (NP (NP (NN macrophage) (JJ inflammatory) (NN protein) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN regulated) (PP (IN on) (NP (NP (NN activation)) (, ,) (NP (NP (NP (JJ normal) (NN T)) (VP (VP (VBN expressed)) (CC and) (VP (VBN secreted)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (NNS receptors)) (VP (VBN involved))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN defined)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NNS Eosinophils)) (VP (VP (VBP undergo) (NP (NN chemotaxis))) (, ,) (VP (VB degranulate)) (, ,) (CC and) (VP (VBP exhibit) (NP (NP (JJ [C2+) (-RRB- -RSB-) (NN i) (NNS changes)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (DT the) (JJ human) (NN CC) (NNS chemokines)) (NP (NP (NN macrophage) (JJ inflammatory) (NN protein) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN regulated) (PP (IN on) (NP (NP (NN activation)) (, ,) (NP (NP (NP (JJ normal) (NN T)) (VP (VP (VBN expressed)) (CC and) (VP (VBN secreted)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (NNS receptors)) (VP (VBN involved))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN defined)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NNS Eosinophils)) (VP (VP (VBP undergo) (NP (NN chemotaxis))) (, ,) (VP (VB degranulate)) (, ,) (CC and) (VP (VBP exhibit) (NP (NP (JJ [C2+) (-RRB- -RSB-) (NN i) (NNS changes)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (DT the) (JJ human) (NN CC) (NNS chemokines)) (NP (NP (NN macrophage) (JJ inflammatory) (NN protein) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (, ,) (VP (VBN regulated) (PP (IN on) (NP (NP (NN activation)) (, ,) (NP (NP (NP (JJ normal) (NN T)) (VP (VP (VBN expressed)) (CC and) (VP (VBN secreted)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (NNS receptors)) (VP (VBN involved))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN defined)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NNS Eosinophils)) (VP (VP (VBP undergo) (NP (NN chemotaxis))) (, ,) (VP (VB degranulate)) (, ,) (CC and) (VP (VBP exhibit) (NP (NP (JJ [C2+) (-RRB- -RSB-) (NN i) (NNS changes)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (DT the) (JJ human) (NN CC) (NNS chemokines)) (NP (NP (NN macrophage) (JJ inflammatory) (NN protein) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (, ,) (VP (VBN regulated) (PP (IN on) (NP (NP (NN activation)) (, ,) (NP (NP (NP (JJ normal) (NN T)) (VP (VP (VBN expressed)) (CC and) (VP (VBN secreted)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (NNS receptors)) (VP (VBN involved))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN defined)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NNS Eosinophils)) (VP (VP (VBP undergo) (NP (NN chemotaxis))) (, ,) (VP (VB degranulate)) (, ,) (CC and) (VP (VBP exhibit) (NP (NP (JJ [C2+) (-RRB- -RSB-) (NN i) (NNS changes)) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (DT the) (JJ human) (NN CC) (NNS chemokines)) (NP (NP (NN macrophage) (JJ inflammatory) (NN protein) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (, ,) (VP (VBN regulated) (PP (IN on) (NP (NP (NN activation)) (, ,) (NP (NP (NP (JJ normal) (NN T)) (VP (VP (VBN expressed)) (CC and) (VP (VBN secreted)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (NNS receptors)) (VP (VBN involved))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN defined)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN isolated) (NP (NP (DT a) (JJ human) (NN cDNA)) (VP (VBG encoding) (NP (NP (DT the) (JJ first) (JJ eosinophil-selective) (NN chemokine) (NN receptor)) (, ,) (VP (VBN designated) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ seven-transmembrane) (ADJP (NN domain) (NN G) (JJ protein-coupled)) (NN receptor)) (ADJP (ADVP (RBS most) (RB closely)) (JJ related) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN reported)) (NN monocyte-)) (CC and) (NP (NP (JJ neutrophil-selective) (NN receptor) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN receptor)))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ seven-transmembrane) (ADJP (NN domain) (NN G) (JJ protein-coupled)) (NN receptor)) (ADJP (ADVP (RBS most) (RB closely)) (JJ related) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN reported)) (NN monocyte-)) (CC and) (NP (NP (JJ neutrophil-selective) (NN receptor) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN receptor)))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ seven-transmembrane) (ADJP (NN domain) (NN G) (JJ protein-coupled)) (NN receptor)) (ADJP (ADVP (RBS most) (RB closely)) (JJ related) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN reported)) (NN monocyte-)) (CC and) (NP (NP (JJ neutrophil-selective) (NN receptor) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (DT the) (NN _PROT_) (NN _PROT2_) (NN receptor)))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ seven-transmembrane) (ADJP (NN domain) (NN G) (JJ protein-coupled)) (NN receptor)) (ADJP (ADVP (RBS most) (RB closely)) (JJ related) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN reported)) (NN monocyte-)) (CC and) (NP (NP (JJ neutrophil-selective) (NN receptor) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN receptor)))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ seven-transmembrane) (ADJP (NN domain) (NN G) (JJ protein-coupled)) (NN receptor)) (ADJP (ADVP (RBS most) (RB closely)) (JJ related) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN reported)) (NN monocyte-)) (CC and) (NP (NP (JJ neutrophil-selective) (NN receptor) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (DT the) (NN _PROT_) (NN _PROT2_) (NN receptor)))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ seven-transmembrane) (ADJP (NN domain) (NN G) (JJ protein-coupled)) (NN receptor)) (ADJP (ADVP (RBS most) (RB closely)) (JJ related) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN reported)) (NN monocyte-)) (CC and) (NP (NP (JJ neutrophil-selective) (NN receptor) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (DT the) (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN receptor)))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_))) (CC and) (NP (NN _PROT_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NP (NN _PROT_))) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NP (NN _PROT_))) (CC and) (NP (NN _PROT_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NP (NN _PROT_))) (CC and) (NP (NN _PROT_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (NP (NN _PROT1_))) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (NP (NN _PROT1_))) (CC and) (NP (NN _PROT_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (NP (NN _PROT1_))) (CC and) (NP (NN _PROT_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (NP (NN _PROT_))) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (NP (NN _PROT_))) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (LST (LS [Ca2+) (-RRB- -RSB-)) (NN i) (NNS changes)) (VP (VBD were) (VP (VBN monitored) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NP (JJ human) (JJ embryonic) (NN kidney) (CD 293)) (NNS cells))))))) (, ,) (NP (NP (NP (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_) (NN _PROT_)) (NP (NN _PROT_))) (CC and) (NP (NN _PROT_))) (VP (VBD were) (NP (NP (DT both) (JJ potent) (NNS agonists)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT2_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT2_) (NP (NP (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT2_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT2_) (NP (NP (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT1_) (NN _PROT1_))))))) (: ;) (S (NP (NN _PROT2_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT1_) (NN _PROT1_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT2_) (NP (NP (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT1_) (NN _PROT1_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT1_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT2_) (NP (NP (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT1_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT_) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT an) (NN agonist)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_))))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD was) (NP (NP (DT an) (NN agonist)) (PP (IN for) (S (VP (VBG _PROT1_) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN gamma) (NN c))) (NNS chains))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN XSCID)) (CC and) (NP (NN XCID))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN gamma) (NN c))) (NNS chains))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN XSCID)) (CC and) (NP (NN XCID))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c))) (NNS chains))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN XSCID)) (CC and) (NP (NN XCID))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling)) (VP (VBZ requires) (NP (NP (DT the) (NN dimerization)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NP (JJ common) (NN gamma)) (PRN (-LRB- -LRB-) (NP (NN gamma) (NN c)) (-RRB- -RRB-)))) (NNS chains)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NNS receptors)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-)) (, ,) (CC and) (NP (NP (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WP$ whose) (NN receptor)) (S (VP (VBZ is) (VP (VBN shown) (ADVP (RB here)) (S (VP (TO to) (VP (VB contain) (NP (NN gamma) (NN c))))))))) (-RRB- -RRB-))) (VP (VBD induced) (NP (NP (DT the) (NP (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (NN activation)))) (PP (IN of) (NP (NP (DT the) (NN Janus) (NN family) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT2_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT2_) (NN c))) (NNS associations))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT2_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT2_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT2_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT2_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT2_) (NN c))) (NNS associations))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (CC and) (NP (VBN increased) (NN _PROT_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (VBN increased) (NN _PROT2_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN gamma) (NN c)) (, ,) (ADVP (RB respectively)))))) (: ;) (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (VBN increased) (NN _PROT2_) (NN c))) (NNS associations))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN gamma) (NN c) (NNS mutations)) (PP (IN in) (NP (NP (NP (QP (IN at) (JJS least) (DT some)) (NN XSCID)) (CC and) (NP (NN XCID))) (NNS patients)))) (VP (VBP prevent) (NP (JJ normal) (NN _PROT1_) (NN activation)) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NNS mutations)) (PP (IN of) (NP (NN _PROT2_)))) (VP (MD may) (VP (VB result) (PP (IN in) (NP (DT an) (JJ XSCID-like) (NN phenotype))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (CD Two) (ADJP (RB potentially) (JJ oncogenic)) (NNS cyclins)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (VP (VBP share) (NP (NP (JJ common) (NNS properties)) (PP (IN of) (NP (NP (NN subunit) (NN configuration)) (, ,) (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (JJ physical) (NN association))))) (PP (IN with) (NP (DT the) (NN _PROT_) (NN protein)))))) |ET|
+1 |BT| (S1 (S (NP (NP (CD Two) (ADJP (RB potentially) (JJ oncogenic)) (NNS cyclins)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (VP (VBP share) (NP (NP (JJ common) (NNS properties)) (PP (IN of) (NP (NP (NN subunit) (NN configuration)) (, ,) (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (JJ physical) (NN association))))) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN protein)))))) |ET|
+1 |BT| (S1 (S (NP (NP (CD Two) (ADJP (RB potentially) (JJ oncogenic)) (NNS cyclins)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (, ,)) (VP (VBP share) (NP (NP (JJ common) (NNS properties)) (PP (IN of) (NP (NP (NN subunit) (NN configuration)) (, ,) (NP (NN tyrosine) (NN phosphorylation)) (CC and) (NP (JJ physical) (NN association))))) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN protein)))))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB .Originally)) (VP (VBN identified) (PP (IN as) (NP (DT a) (`` ') (JJ mitotic) (NN cyclin) ('' '))))) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ exhibits) (NP (NP (NP (NNS properties)) (PP (IN of) (NP (NP (NN growth) (NN factor)) (NN sensitivity)))) (, ,) (NP (NP (NN susceptibility)) (PP (TO to) (NP (JJ viral) (NN subversion)))) (CC and) (NP (NP (NN association)) (PP (IN with) (NP (NP (DT a) (JJ tumor-suppressor) (NN protein)) (, ,) (NP (NP (NNS properties)) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ indicative) (PP (IN of) (NP (NP (NP (DT an) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CONJP (RB as) (RB well) (IN as)) (NP (DT a) (NN candidate) (NN proto-oncogene)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB .Originally)) (VP (VBN identified) (PP (IN as) (NP (DT a) (`` ') (JJ mitotic) (NN cyclin) ('' '))))) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ exhibits) (NP (NP (NP (NNS properties)) (PP (IN of) (NP (NP (NN growth) (NN factor)) (NN sensitivity)))) (, ,) (NP (NP (NN susceptibility)) (PP (TO to) (NP (JJ viral) (NN subversion)))) (CC and) (NP (NP (NN association)) (PP (IN with) (NP (NP (DT a) (JJ tumor-suppressor) (NN protein)) (, ,) (NP (NP (NNS properties)) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ indicative) (PP (IN of) (NP (NP (NP (DT an) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CONJP (RB as) (RB well) (IN as)) (NP (DT a) (NN candidate) (NN proto-oncogene)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB .Originally)) (VP (VBN identified) (PP (IN as) (NP (DT a) (`` ') (JJ mitotic) (NN cyclin) ('' '))))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ exhibits) (NP (NP (NP (NNS properties)) (PP (IN of) (NP (NP (NN growth) (NN factor)) (NN sensitivity)))) (, ,) (NP (NP (NN susceptibility)) (PP (TO to) (NP (JJ viral) (NN subversion)))) (CC and) (NP (NP (NN association)) (PP (IN with) (NP (NP (DT a) (JJ tumor-suppressor) (NN protein)) (, ,) (NP (NP (NNS properties)) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ indicative) (PP (IN of) (NP (NP (NP (DT an) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CONJP (RB as) (RB well) (IN as)) (NP (DT a) (NN candidate) (NN proto-oncogene)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Other) (JJ recent) (NNS studies)) (VP (VBP have) (VP (VBN identified) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN as) (NP (NP (DT a) (JJ putative) (NN G1) (NN cyclin)) (CC and) (NP (NN candidate) (NN proto-oncogene))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (VP (VBN found) (S (VP (VP (TO to) (VP (VB be) (VP (VBN phosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (ADVP (FW in) (FW vivo))))) (CC and) (, ,) (PP (IN like) (NP (NN _PROT2_) (NN _PROT2_))) (, ,) (VP (VBD was) (ADVP (RB readily)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (VP (VBN found) (S (VP (VP (TO to) (VP (VB be) (VP (VBN phosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (ADVP (FW in) (FW vivo))))) (CC and) (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (VP (VBD was) (ADVP (RB readily)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBD was) (VP (VBN found) (S (VP (VP (TO to) (VP (VB be) (VP (VBN phosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (ADVP (FW in) (FW vivo))))) (CC and) (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (VP (VBD was) (ADVP (RB readily)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (JJ synchronized) (JJ human) (NN osteosarcoma) (NNS cells))) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN induced) (PP (IN in) (NP (JJ early) (NN G1))))) (CC and) (VP (VBZ becomes) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ Cdk-binding) (NN subunit)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (PP (IN with) (NP (NP (JJ human) (NN osteosarcoma) (NNS cells)) (CC and) (NP (NP (NN Ewing) (POS 's)) (NN sarcoma) (NNS cells))))) (VP (VBD demonstrated) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN _PROT_)) (JJ immune) (NNS complexes)) (VP (VBP exhibit) (NP (JJ appreciable) (NN histone) (NN H1) (NN kinase) (NN activity)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (PP (IN with) (NP (NP (JJ human) (NN osteosarcoma) (NNS cells)) (CC and) (NP (NP (NN Ewing) (POS 's)) (NN sarcoma) (NNS cells))))) (VP (VBD demonstrated) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN _PROT_)) (JJ immune) (NNS complexes)) (VP (VBP exhibit) (NP (JJ appreciable) (NN histone) (NN H1) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (PP (IN with) (NP (NP (JJ human) (NN osteosarcoma) (NNS cells)) (CC and) (NP (NP (NN Ewing) (POS 's)) (NN sarcoma) (NNS cells))))) (VP (VBD demonstrated) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (JJ immune) (NNS complexes)) (VP (VBP exhibit) (NP (JJ appreciable) (NN histone) (NN H1) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (PP (IN with) (NP (NP (JJ human) (NN osteosarcoma) (NNS cells)) (CC and) (NP (NP (NN Ewing) (POS 's)) (NN sarcoma) (NNS cells))))) (VP (VBD demonstrated) (SBAR (SBAR (IN that) (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN _PROT_)) (JJ immune) (NNS complexes)) (VP (VBP exhibit) (NP (JJ appreciable) (NN histone) (NN H1) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (PP (IN with) (NP (NP (JJ human) (NN osteosarcoma) (NNS cells)) (CC and) (NP (NP (NN Ewing) (POS 's)) (NN sarcoma) (NNS cells))))) (VP (VBD demonstrated) (SBAR (SBAR (IN that) (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (JJ immune) (NNS complexes)) (VP (VBP exhibit) (NP (JJ appreciable) (NN histone) (NN H1) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (PP (IN with) (NP (NP (JJ human) (NN osteosarcoma) (NNS cells)) (CC and) (NP (NP (NN Ewing) (POS 's)) (NN sarcoma) (NNS cells))))) (VP (VBD demonstrated) (SBAR (SBAR (IN that) (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (JJ immune) (NNS complexes)) (VP (VBP exhibit) (NP (JJ appreciable) (NN histone) (NN H1) (NN kinase) (NN activity)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (DT the) (CD two) (NN hybrid) (NN system)))) (VP (TO to) (VP (VB detect) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NP (DT the) (NN protein-tyrosine-phosphatase)) (, ,) (NP (NN _PROT1_)) (, ,))) (PP (IN with) (NP (NP (DT another) (JJ SH2-containing) (NN protein)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))) (PP (IN after) (NP (NN ligand) (NN stimulation))))) (, ,) (CC and) (S (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT this) (NN receptor)))) (VP (VBZ promotes) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VP (VBG Using) (NP (NN _PROT1_)) (PP (IN as) (NP (NN bait)))) (CC and) (VP (VBG supplying) (NP (NP (DT an) (JJ exogenous) (NN tyrosine) (NN kinase)) (NN gene)) (PP (TO to) (NP (DT the) (NN yeast) (NNS cells)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN found) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT another) (NN signaling) (NN protein)) (, ,) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VP (VBG Using) (NP (NN _PROT1_)) (PP (IN as) (NP (NN bait)))) (CC and) (VP (VBG supplying) (NP (NP (DT an) (JJ exogenous) (NN tyrosine) (NN kinase)) (NN gene)) (PP (TO to) (NP (DT the) (NN yeast) (NNS cells)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT another) (NN signaling) (NN protein)) (, ,) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VP (VBG Using) (NP (NN _PROT_)) (PP (IN as) (NP (NN bait)))) (CC and) (VP (VBG supplying) (NP (NP (DT an) (JJ exogenous) (NN tyrosine) (NN kinase)) (NN gene)) (PP (TO to) (NP (DT the) (NN yeast) (NNS cells)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN found) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT another) (NN signaling) (NN protein)) (, ,) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN localized) (NP (NP (DT the) (NN region)) (PP (IN of) (NP (NN interaction))) (PP (TO to) (NP (NN tyrosine) (CD 580)))) (PP (IN in) (NP (NP (DT the) (JJ carboxyl) (NN end)) (PP (IN of) (NP (NN _PROT1_))))) (CC and) (PP (TO to) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN in) (NP (NP (DT the) (NN carboxy-terminus)) (PP (IN of) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro)) (PP (IN under) (NP (NP (NNS conditions)) (SBAR (WHADVP (WRB where)) (S (NP (DT the) (JJ latter)) (VP (VBZ is) (VP (VBN tyrosine-phosphorylated)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Interactions)) (VP (VBG involving) (NP (NP (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II)) (NP (NN transcription/nucleotide) (NN excision) (NN repair) (NN complex) (NN _PROT1_))) (, ,) (NP (NP (DT the) (NN nucleotide) (NN excision) (NN repair)) (NN protein) (NN _PROT2_)) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Interactions)) (VP (VBG involving) (NP (NP (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II)) (NP (NN transcription/nucleotide) (NN excision) (NN repair) (NN complex) (NN _PROT1_))) (, ,) (NP (NP (DT the) (NN nucleotide) (NN excision) (NN repair)) (NN protein) (NN _PROT_)) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Interactions)) (VP (VBG involving) (NP (NP (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II)) (NP (NN transcription/nucleotide) (NN excision) (NN repair) (NN complex) (NN _PROT1_))) (, ,) (NP (NP (DT the) (NN nucleotide) (NN excision) (NN repair)) (NN protein) (NN _PROT_)) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NNS Interactions)) (VP (VBG involving) (NP (NP (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II)) (NP (NN transcription/nucleotide) (NN excision) (NN repair) (NN complex) (NN _PROT_))) (, ,) (NP (NP (DT the) (NN nucleotide) (NN excision) (NN repair)) (NN protein) (NN _PROT1_)) (, ,) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Interactions)) (VP (VBG involving) (NP (NP (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II)) (NP (NN transcription/nucleotide) (NN excision) (NN repair) (NN complex) (NN _PROT_))) (, ,) (NP (NP (DT the) (NN nucleotide) (NN excision) (NN repair)) (NN protein) (NN _PROT1_)) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS Interactions)) (VP (VBG involving) (NP (NP (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II)) (NP (NN transcription/nucleotide) (NN excision) (NN repair) (NN complex) (NN _PROT_))) (, ,) (NP (NP (DT the) (NN nucleotide) (NN excision) (NN repair)) (NN protein) (NN _PROT_)) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (QP (IN At) (JJS least) (CD two)) (PP (IN of) (NP (NP (DT the) (NNS subunits)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)) (NP (NNS proteins))) (-RRB- -RRB-))))))) (VP (VBP are) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN disease) (NN xeroderma) (NN pigmentosum)) (PRN (-LRB- -LRB-) (NP (NN XP)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (QP (IN At) (JJS least) (CD two)) (PP (IN of) (NP (NP (DT the) (NNS subunits)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)) (NP (NNS proteins))) (-RRB- -RRB-))))))) (VP (VBP are) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN disease) (NN xeroderma) (NN pigmentosum)) (PRN (-LRB- -LRB-) (NP (NN XP)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (QP (IN At) (JJS least) (CD two)) (PP (IN of) (NP (NP (DT the) (NNS subunits)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NNS proteins))) (-RRB- -RRB-))))))) (VP (VBP are) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN disease) (NN xeroderma) (NN pigmentosum)) (PRN (-LRB- -LRB-) (NP (NN XP)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN exploited) (NP (NP (DT the) (NN availability)) (PP (IN of) (NP (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_))) (NNS genes)) (-LRB- -LRB-) (SBAR (WHNP (NP (DT all)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP encode) (NP (NP (NN polypeptide) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB examine) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (ADJP (FW in) (VBN vitro-translated)) (NNS polypeptides)) (PP (IN by) (NP (NN co-immunoprecipitation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Additionally)) (NP (PRP we)) (VP (VBP have) (VP (VBN examined) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_) (NNS components)) (, ,) (NP (DT the) (JJ human) (NN NER) (NN protein) (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT_) (NN protein)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN implicated) (PP (IN in) (NP (NP (NN Cockayne) (NN syndrome)) (PRN (-LRB- -LRB-) (NP (NN CS)) (-RRB- -RRB-))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Additionally)) (NP (PRP we)) (VP (VBP have) (VP (VBN examined) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_) (NNS components)) (, ,) (NP (DT the) (JJ human) (NN NER) (NN protein) (NN _PROT_)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT2_) (NN protein)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN implicated) (PP (IN in) (NP (NP (NN Cockayne) (NN syndrome)) (PRN (-LRB- -LRB-) (NP (NN CS)) (-RRB- -RRB-))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Additionally)) (NP (PRP we)) (VP (VBP have) (VP (VBN examined) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_) (NNS components)) (, ,) (NP (DT the) (JJ human) (NN NER) (NN protein) (NN _PROT1_)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT2_) (NN protein)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN implicated) (PP (IN in) (NP (NP (NN Cockayne) (NN syndrome)) (PRN (-LRB- -LRB-) (NP (NN CS)) (-RRB- -RRB-))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS analyses)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (DT each) (JJ other)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS analyses)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (DT each) (JJ other)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS analyses)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (DT each) (JJ other)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS analyses)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (DT each) (JJ other)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS analyses)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (DT each) (JJ other)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS analyses)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (DT each) (JJ other)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN protein)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ multiple) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))) (CC and) (PP (IN with) (NP (NN _PROT_) (NN protein)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN protein)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ multiple) (NNS subunits)) (PP (IN of) (NP (NN _PROT_))))) (CC and) (PP (IN with) (NP (NN _PROT2_) (NN protein)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN protein)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ multiple) (NNS subunits)) (PP (IN of) (NP (NN _PROT1_))))) (CC and) (PP (IN with) (NP (NN _PROT2_) (NN protein)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Physical) (NN interaction)) (PP (IN of) (NP (JJ mammalian) (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBD was) (ADVP (RB originally)) (VP (VBN identified) (PP (IN as) (NP (DT a) (NN Start) (NN gene))) (PP (IN in) (NP (JJ budding) (NN yeast))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NP (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NNS cyclins)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ controls) (NP (NN progression)) (PP (IN through) (NP (NP (NN G1)) (PP (IN of) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN detected) (NP (NP (NP (DT a) (JJ specific) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (DT the) (JJ molecular) (NN chaperon) (NN _PROT2_)))) (CC and) (NP (NP (DT a) (JJ 44-kDa) (NN protein)) (SBAR (WHNP (WDT that)) (S (NP (PRP we)) (VP (VB identify) (PP (IN as) (NP (JJ mammalian) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN detected) (NP (NP (NP (DT a) (JJ specific) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (DT the) (JJ molecular) (NN chaperon) (NN _PROT_)))) (CC and) (NP (NP (DT a) (JJ 44-kDa) (NN protein)) (SBAR (WHNP (WDT that)) (S (NP (PRP we)) (VP (VB identify) (PP (IN as) (NP (JJ mammalian) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN detected) (NP (NP (NP (DT a) (JJ specific) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (DT the) (JJ molecular) (NN chaperon) (NN _PROT1_)))) (CC and) (NP (NP (DT a) (JJ 44-kDa) (NN protein)) (SBAR (WHNP (WDT that)) (S (NP (PRP we)) (VP (VB identify) (PP (IN as) (NP (JJ mammalian) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle)) (PP (IN through) (NP (NP (DT a) (JJ direct) (NN effect)) (PP (IN on) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD may) (VP (VB regulate) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle)) (PP (IN through) (NP (NP (DT a) (JJ direct) (NN effect)) (PP (IN on) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle)) (PP (IN through) (NP (NP (DT a) (JJ direct) (NN effect)) (PP (IN on) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD may) (VP (VB regulate) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle)) (PP (IN through) (NP (NP (DT a) (JJ direct) (NN effect)) (PP (IN on) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle)) (PP (IN through) (NP (NP (DT a) (JJ direct) (NN effect)) (PP (IN on) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (DT the) (JJ mammalian) (NN cell) (NN cycle)) (PP (IN through) (NP (NP (DT a) (JJ direct) (NN effect)) (PP (IN on) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (MD may) (ADVP (RB also)) (VP (VBP imply) (NP (NP (DT a) (JJ mechanistic) (NN link)) (PP (IN between) (NP (NP (DT the) (NNS functions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (NN recruitment) (PP (IN by) (NP (NP (CD two) (JJ distinct) (ADJP (ADJP (JJ ligand-induced)) (, ,) (ADJP (JJ tyrosine-phosphorylated))) (NN docking) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN _PROT_) (JJ intracellular) (NN domain))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (NN recruitment) (PP (IN by) (NP (NP (CD two) (JJ distinct) (ADJP (ADJP (JJ ligand-induced)) (, ,) (ADJP (JJ tyrosine-phosphorylated))) (NN docking) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (JJ intracellular) (NN domain))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (NN recruitment) (PP (IN by) (NP (NP (CD two) (JJ distinct) (ADJP (ADJP (JJ ligand-induced)) (, ,) (ADJP (JJ tyrosine-phosphorylated))) (NN docking) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (JJ intracellular) (NN domain))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB define) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (NP (NP (NP (NP (NN signal) (NN transducer)) (CC and) (NP (NN activator))) (PP (IN of) (NP (NN transcription)))) (PRN (-LRB- -LRB-) (NP (NN STAT)) (-RRB- -RRB-))) (NN protein) (NN recruitment)) (PP (TO to) (NP (DT the) (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_))))))))) (, ,) (NP (NP (DT the) (NN STAT) (NNS proteins)) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (JJ different) (NN cell) (NNS populations))))) (VP (VBD were) (ADVP (RB first)) (VP (VBN defined) (S (VP (VBG using) (NP (JJ electrophoretic) (NN mobility) (NN shift) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB define) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (NP (NP (NP (NP (NN signal) (NN transducer)) (CC and) (NP (NN activator))) (PP (IN of) (NP (NN transcription)))) (PRN (-LRB- -LRB-) (NP (NN STAT)) (-RRB- -RRB-))) (NN protein) (NN recruitment)) (PP (TO to) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_))))))))) (, ,) (NP (NP (DT the) (NN STAT) (NNS proteins)) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (JJ different) (NN cell) (NNS populations))))) (VP (VBD were) (ADVP (RB first)) (VP (VBN defined) (S (VP (VBG using) (NP (JJ electrophoretic) (NN mobility) (NN shift) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB define) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (NP (NP (NP (NP (NN signal) (NN transducer)) (CC and) (NP (NN activator))) (PP (IN of) (NP (NN transcription)))) (PRN (-LRB- -LRB-) (NP (NN STAT)) (-RRB- -RRB-))) (NN protein) (NN recruitment)) (PP (TO to) (NP (DT the) (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_))))))))) (, ,) (NP (NP (DT the) (NN STAT) (NNS proteins)) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ different) (NN cell) (NNS populations))))) (VP (VBD were) (ADVP (RB first)) (VP (VBN defined) (S (VP (VBG using) (NP (JJ electrophoretic) (NN mobility) (NN shift) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB define) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (NP (NP (NP (NP (NN signal) (NN transducer)) (CC and) (NP (NN activator))) (PP (IN of) (NP (NN transcription)))) (PRN (-LRB- -LRB-) (NP (NN STAT)) (-RRB- -RRB-))) (NN protein) (NN recruitment)) (PP (TO to) (NP (DT the) (NP (NP (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_))))))))) (, ,) (NP (NP (DT the) (NN STAT) (NNS proteins)) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (JJ different) (NN cell) (NNS populations))))) (VP (VBD were) (ADVP (RB first)) (VP (VBN defined) (S (VP (VBG using) (NP (JJ electrophoretic) (NN mobility) (NN shift) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB define) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (NP (NP (NP (NP (NN signal) (NN transducer)) (CC and) (NP (NN activator))) (PP (IN of) (NP (NN transcription)))) (PRN (-LRB- -LRB-) (NP (NN STAT)) (-RRB- -RRB-))) (NN protein) (NN recruitment)) (PP (TO to) (NP (DT the) (NP (NP (NN _PROT_) (CD _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_))))))))) (, ,) (NP (NP (DT the) (NN STAT) (NNS proteins)) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ different) (NN cell) (NNS populations))))) (VP (VBD were) (ADVP (RB first)) (VP (VBN defined) (S (VP (VBG using) (NP (JJ electrophoretic) (NN mobility) (NN shift) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB define) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (NP (NP (NP (NP (NN signal) (NN transducer)) (CC and) (NP (NN activator))) (PP (IN of) (NP (NN transcription)))) (PRN (-LRB- -LRB-) (NP (NN STAT)) (-RRB- -RRB-))) (NN protein) (NN recruitment)) (PP (TO to) (NP (DT the) (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_))))))))) (, ,) (NP (NP (DT the) (NN STAT) (NNS proteins)) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ different) (NN cell) (NNS populations))))) (VP (VBD were) (ADVP (RB first)) (VP (VBN defined) (S (VP (VBG using) (NP (JJ electrophoretic) (NN mobility) (NN shift) (NNS assays))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT all) (NNS cells)) (VP (VBN tested)))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBD activated) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (CC and) (VP (VBD induced) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (CD three) (JJ distinct) (NN DNA) (NN binding) (NNS complexes)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (JJ different) (NNS combinations)) (PP (IN of) (NP (DT these) (CD two) (NN transcription) (NNS factors))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT all) (NNS cells)) (VP (VBN tested)))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBD activated) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (CC and) (VP (VBD induced) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (CD three) (JJ distinct) (NN DNA) (NN binding) (NNS complexes)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (JJ different) (NNS combinations)) (PP (IN of) (NP (DT these) (CD two) (NN transcription) (NNS factors))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT all) (NNS cells)) (VP (VBN tested)))) (, ,) (NP (NN _PROT_)) (VP (VP (VBD activated) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (CC and) (VP (VBD induced) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (CD three) (JJ distinct) (NN DNA) (NN binding) (NNS complexes)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (JJ different) (NNS combinations)) (PP (IN of) (NP (DT these) (CD two) (NN transcription) (NNS factors))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NN Ba/F3) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB stably)) (VP (VBD expressed) (NP (DT the) (JJ murine) (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT_)) (PP (IN in) (NP (NP (NN Ba/F3) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB stably)) (VP (VBD expressed) (NP (DT the) (JJ murine) (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT_)) (PP (IN in) (NP (NP (NN Ba/F3) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB stably)) (VP (VBD expressed) (NP (DT the) (JJ murine) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT1_)) (PP (IN in) (NP (NP (NN Ba/F3) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB stably)) (VP (VBD expressed) (NP (DT the) (JJ murine) (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT1_)) (PP (IN in) (NP (NP (NN Ba/F3) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB stably)) (VP (VBD expressed) (NP (DT the) (JJ murine) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT_)) (PP (IN in) (NP (NP (NN Ba/F3) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB stably)) (VP (VBD expressed) (NP (DT the) (JJ murine) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (JJ structure-function) (NN mutagenesis) (NN approach)))) (, ,) (NP (NP (NP (CD two) (NN tyrosine) (NNS residues)) (PRN (-LRB- -LRB-) (NP (NP (NN Tyr427)) (CC and) (NP (NN Tyr477))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (DT the) (JJ murine) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB redundantly)) (VP (VBN required) (PP (IN for) (NP (NN receptor) (NN function))) (PP (CC and) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_))))) (CC but) (PP (RB not) (IN for) (NP (NP (NN _PROT_)) (CC or) (NP (NN Stat5)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (JJ structure-function) (NN mutagenesis) (NN approach)))) (, ,) (NP (NP (NP (CD two) (NN tyrosine) (NNS residues)) (PRN (-LRB- -LRB-) (NP (NP (NN Tyr427)) (CC and) (NP (NN Tyr477))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (DT the) (JJ murine) (NN _PROT1_) (NN _PROT_)))))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB redundantly)) (VP (VBN required) (PP (IN for) (NP (NN receptor) (NN function))) (PP (CC and) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_))))) (CC but) (PP (RB not) (IN for) (NP (NP (NN _PROT_)) (CC or) (NP (NN Stat5)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (JJ structure-function) (NN mutagenesis) (NN approach)))) (, ,) (NP (NP (NP (CD two) (NN tyrosine) (NNS residues)) (PRN (-LRB- -LRB-) (NP (NP (NN Tyr427)) (CC and) (NP (NN Tyr477))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (DT the) (JJ murine) (NN _PROT1_) (NN _PROT_)))))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB redundantly)) (VP (VBN required) (PP (IN for) (NP (NN receptor) (NN function))) (PP (CC and) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_))))) (CC but) (PP (RB not) (IN for) (NP (NP (NN _PROT2_)) (CC or) (NP (NN Stat5)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (JJ structure-function) (NN mutagenesis) (NN approach)))) (, ,) (NP (NP (NP (CD two) (NN tyrosine) (NNS residues)) (PRN (-LRB- -LRB-) (NP (NP (NN Tyr427)) (CC and) (NP (NN Tyr477))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (DT the) (JJ murine) (NN _PROT1_) (NN _PROT1_)))))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB redundantly)) (VP (VBN required) (PP (IN for) (NP (NN receptor) (NN function))) (PP (CC and) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_))))) (CC but) (PP (RB not) (IN for) (NP (NP (NN _PROT_)) (CC or) (NP (NN Stat5)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (JJ structure-function) (NN mutagenesis) (NN approach)))) (, ,) (NP (NP (NP (CD two) (NN tyrosine) (NNS residues)) (PRN (-LRB- -LRB-) (NP (NP (NN Tyr427)) (CC and) (NP (NN Tyr477))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (DT the) (JJ murine) (NN _PROT1_) (NN _PROT1_)))))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB redundantly)) (VP (VBN required) (PP (IN for) (NP (NN receptor) (NN function))) (PP (CC and) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_))))) (CC but) (PP (RB not) (IN for) (NP (NP (NN _PROT2_)) (CC or) (NP (NN Stat5)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (JJ structure-function) (NN mutagenesis) (NN approach)))) (, ,) (NP (NP (NP (CD two) (NN tyrosine) (NNS residues)) (PRN (-LRB- -LRB-) (NP (NP (NN Tyr427)) (CC and) (NP (NN Tyr477))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (DT the) (JJ murine) (NN _PROT_) (NN _PROT_)))))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB redundantly)) (VP (VBN required) (PP (IN for) (NP (NN receptor) (NN function))) (PP (CC and) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_))))) (CC but) (PP (RB not) (IN for) (NP (NP (NN _PROT2_)) (CC or) (NP (NN Stat5)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Twelve) (NN amino) (NN acid) (NNS peptides)) (VP (VBG encompassing) (NP (NP (DT either)) (PP (IN of) (NP (NP (DT these) (CD two) (NN tyrosine) (NNS residues)) (PP (IN in) (NP (JJ phosphorylated) (NN form)))))))) (VP (VP (VBD coprecipitated) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)))) (CC and) (VP (VBD blocked) (NP (JJ _PROT_) (NN _PROT_) (NN phosphorylation)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Twelve) (NN amino) (NN acid) (NNS peptides)) (VP (VBG encompassing) (NP (NP (DT either)) (PP (IN of) (NP (NP (DT these) (CD two) (NN tyrosine) (NNS residues)) (PP (IN in) (NP (JJ phosphorylated) (NN form)))))))) (VP (VP (VBD coprecipitated) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_)))) (CC and) (VP (VBD blocked) (NP (JJ _PROT2_) (NN _PROT_) (NN phosphorylation)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Twelve) (NN amino) (NN acid) (NNS peptides)) (VP (VBG encompassing) (NP (NP (DT either)) (PP (IN of) (NP (NP (DT these) (CD two) (NN tyrosine) (NNS residues)) (PP (IN in) (NP (JJ phosphorylated) (NN form)))))))) (VP (VP (VBD coprecipitated) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_)))) (CC and) (VP (VBD blocked) (NP (JJ _PROT_) (NN _PROT2_) (NN phosphorylation)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Twelve) (NN amino) (NN acid) (NNS peptides)) (VP (VBG encompassing) (NP (NP (DT either)) (PP (IN of) (NP (NP (DT these) (CD two) (NN tyrosine) (NNS residues)) (PP (IN in) (NP (JJ phosphorylated) (NN form)))))))) (VP (VP (VBD coprecipitated) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)))) (CC and) (VP (VBD blocked) (NP (JJ _PROT2_) (NN _PROT_) (NN phosphorylation)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Twelve) (NN amino) (NN acid) (NNS peptides)) (VP (VBG encompassing) (NP (NP (DT either)) (PP (IN of) (NP (NP (DT these) (CD two) (NN tyrosine) (NNS residues)) (PP (IN in) (NP (JJ phosphorylated) (NN form)))))))) (VP (VP (VBD coprecipitated) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)))) (CC and) (VP (VBD blocked) (NP (JJ _PROT_) (NN _PROT2_) (NN phosphorylation)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Twelve) (NN amino) (NN acid) (NNS peptides)) (VP (VBG encompassing) (NP (NP (DT either)) (PP (IN of) (NP (NP (DT these) (CD two) (NN tyrosine) (NNS residues)) (PP (IN in) (NP (JJ phosphorylated) (NN form)))))))) (VP (VP (VBD coprecipitated) (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_)))) (CC and) (VP (VBD blocked) (NP (JJ _PROT1_) (NN _PROT2_) (NN phosphorylation)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (JJ tyrosine-phosphorylated) (NNS peptides)) (VP (VBG containing) (NP (NP (NN Tyr374)) (CC or) (NP (NN Tyr396))))) (VP (VBD did) (RB not) (VP (VP (VB interact) (PP (IN with) (NP (NN _PROT1_)))) (CC or) (VP (VB block) (NP (NN _PROT2_) (NN activation)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT_) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT_) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT2_) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT_) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT2_) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT2_) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN recruited) (PP (TO to) (NP (DT the) (JJ ligand-activated) (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (ADJP (ADJP (JJ specific)) (CC but) (ADJP (JJ redundant))) (NN receptor) (JJ intracellular) (NN domain) (NNS sequences)) (VP (VBG containing) (NP (NN phosphotyrosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Competitive) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (TO to) (NP (DT the) (JJ _PROT_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Competitive) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (DT the) (JJ _PROT2_) (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Competitive) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (DT the) (JJ _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT2_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT2_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT2_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT2_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT2_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT2_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT2_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT2_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT2_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT2_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT2_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT2_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT1_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT2_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT1_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT2_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT1_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT2_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT1_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT1_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT1_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT1_) (NN _PROT2_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT1_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT2_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT1_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT1_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT1_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT1_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT2_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT1_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT1_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT1_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT1_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT1_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT1_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT1_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN NMDA) (-LRB- -LRB-) (NN N-methyl-D-aspartate) (-RRB- -RRB-) (NNS receptors)))) (VP (VBZ is) (ADJP (ADJP (JJ mechanosensitive)) (CC and) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (VP (VBG suggesting) (NP (NP (NP (DT a) (ADJP (RB functionally) (JJ important)) (NN interaction)) (PP (IN between) (NP (JJ NMDA) (NNS receptors)))) (CC and) (NP (NP (DT the) (JJ postsynaptic) (NN cytoskeleton.) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN of) (NP (JJ _PROT_) (NNS proteins)))))) (, ,))) (VP (VBZ is) (VP (VBN identified) (ADVP (RB here)) (PP (IN as) (NP (NP (DT a) (NN brain) (JJ postsynaptic) (NN density) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ colocalizes) (PP (IN in) (NP (JJ dendritic) (NNS spines))) (PP (IN with) (NP (JJ NMDA) (NNS receptors)))))))))))))) (CC and) (S (NP (DT the) (JJ putative) (JJ NMDA) (JJ receptor-clustering) (NN molecule) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ binds) (PP (IN by) (NP (PRP$ its) (JJ central) (NN rod) (NN domain))) (PP (TO to) (NP (NP (DT the) (JJ cytoplasmic) (NN tail)) (PP (IN of) (NP (NP (DT both) (NN _PROT_) (CC and) (NN _PROT_) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN _PROT1_)))))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN immunoprecipitated) (PP (IN with) (NP (NP (JJ NMDA) (NNS receptors)) (CC and) (NP (NP (NN _PROT2_)) (PP (IN from) (NP (NN rat) (NN brain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Intriguingly)) (, ,) (NP (NN _PROT1_AND_PROT2_) (NN binding)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN antagonized) (PP (IN by) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Intriguingly)) (, ,) (NP (NN _PROT1_) (NN binding)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN antagonized) (PP (IN by) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Intriguingly)) (, ,) (NP (NN _PROT1_) (NN binding)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN antagonized) (PP (IN by) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (JJ activated) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (PRP$ its) (JJ specific) (NN inhibitor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (PP (IN _PROT_) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (JJ activated) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (PRP$ its) (JJ specific) (NN inhibitor)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (IN _PROT2_) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (JJ activated) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (PRP$ its) (JJ specific) (NN inhibitor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (PP (IN _PROT_) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (JJ activated) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (PRP$ its) (JJ specific) (NN inhibitor)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (IN _PROT2_) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (JJ activated) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (PRP$ its) (JJ specific) (NN inhibitor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (PP (IN _PROT_) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (JJ activated) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (PRP$ its) (JJ specific) (NN inhibitor)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PP (IN _PROT1_) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN _PROT1_) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ mutant))) (NP (NP (JJ human) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NNS proteins)))) (PP (IN in) (NP (NN SF9) (NNS cells))) (PP (IN by) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN _PROT1_) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ mutant))) (NP (NP (JJ human) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NNS proteins)))) (PP (IN in) (NP (NN SF9) (NNS cells))) (PP (IN by) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN _PROT1_) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ mutant))) (NP (NP (JJ human) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS proteins)))) (PP (IN in) (NP (NN SF9) (NNS cells))) (PP (IN by) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PP (IN _PROT_) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ mutant))) (NP (NP (JJ human) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NNS proteins)))) (PP (IN in) (NP (NN SF9) (NNS cells))) (PP (IN by) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PP (IN _PROT_) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ mutant))) (NP (NP (JJ human) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS proteins)))) (PP (IN in) (NP (NN SF9) (NNS cells))) (PP (IN by) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PP (IN _PROT_) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ mutant))) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS proteins)))) (PP (IN in) (NP (NN SF9) (NNS cells))) (PP (IN by) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Wild-type) (NN _PROT1_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN _PROT2_) (NN mutant)) (VP (VBG lacking) (NP (NP (DT the) (JJ C-terminal) (JJ hemopexin-like) (NN domain) (JJ [des-)) (PRN (-LRB- -LRB-) (NP (CD 248-450) (-RRB- -RRB-) (NN _PROT_)) (-RRB- -RSB-))))) (, ,)) (VP (VBP exhibit) (NP (JJ enzymatic) (NN activity)) (PP (IN upon) (NP (NP (NN cleavage)) (PP (IN of) (NP (DT the) (NN prodomain))) (PP (IN by) (NP (NP (NN treatment)) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (JJ 4-aminophenylmercuric) (NN acetate)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Wild-type) (NN _PROT1_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN _PROT_) (NN mutant)) (VP (VBG lacking) (NP (NP (DT the) (JJ C-terminal) (JJ hemopexin-like) (NN domain) (JJ [des-)) (PRN (-LRB- -LRB-) (NP (CD 248-450) (-RRB- -RRB-) (NN _PROT2_)) (-RRB- -RSB-))))) (, ,)) (VP (VBP exhibit) (NP (JJ enzymatic) (NN activity)) (PP (IN upon) (NP (NP (NN cleavage)) (PP (IN of) (NP (DT the) (NN prodomain))) (PP (IN by) (NP (NP (NN treatment)) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (JJ 4-aminophenylmercuric) (NN acetate)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Wild-type) (NN _PROT1_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN _PROT_) (NN mutant)) (VP (VBG lacking) (NP (NP (DT the) (JJ C-terminal) (JJ hemopexin-like) (NN domain) (JJ [des-)) (PRN (-LRB- -LRB-) (NP (CD 248-450) (-RRB- -RRB-) (NN _PROT_)) (-RRB- -RSB-))))) (, ,)) (VP (VBP exhibit) (NP (JJ enzymatic) (NN activity)) (PP (IN upon) (NP (NP (NN cleavage)) (PP (IN of) (NP (DT the) (NN prodomain))) (PP (IN by) (NP (NP (NN treatment)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (JJ 4-aminophenylmercuric) (NN acetate)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Wild-type) (NN _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN _PROT1_) (NN mutant)) (VP (VBG lacking) (NP (NP (DT the) (JJ C-terminal) (JJ hemopexin-like) (NN domain) (JJ [des-)) (PRN (-LRB- -LRB-) (NP (CD 248-450) (-RRB- -RRB-) (NN _PROT2_)) (-RRB- -RSB-))))) (, ,)) (VP (VBP exhibit) (NP (JJ enzymatic) (NN activity)) (PP (IN upon) (NP (NP (NN cleavage)) (PP (IN of) (NP (DT the) (NN prodomain))) (PP (IN by) (NP (NP (NN treatment)) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (JJ 4-aminophenylmercuric) (NN acetate)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Wild-type) (NN _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN _PROT1_) (NN mutant)) (VP (VBG lacking) (NP (NP (DT the) (JJ C-terminal) (JJ hemopexin-like) (NN domain) (JJ [des-)) (PRN (-LRB- -LRB-) (NP (CD 248-450) (-RRB- -RRB-) (NN _PROT_)) (-RRB- -RSB-))))) (, ,)) (VP (VBP exhibit) (NP (JJ enzymatic) (NN activity)) (PP (IN upon) (NP (NP (NN cleavage)) (PP (IN of) (NP (DT the) (NN prodomain))) (PP (IN by) (NP (NP (NN treatment)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (JJ 4-aminophenylmercuric) (NN acetate)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Wild-type) (NN _PROT_)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN _PROT_) (NN mutant)) (VP (VBG lacking) (NP (NP (DT the) (JJ C-terminal) (JJ hemopexin-like) (NN domain) (JJ [des-)) (PRN (-LRB- -LRB-) (NP (CD 248-450) (-RRB- -RRB-) (NN _PROT1_)) (-RRB- -RSB-))))) (, ,)) (VP (VBP exhibit) (NP (JJ enzymatic) (NN activity)) (PP (IN upon) (NP (NP (NN cleavage)) (PP (IN of) (NP (DT the) (NN prodomain))) (PP (IN by) (NP (NP (NN treatment)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (JJ 4-aminophenylmercuric) (NN acetate)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Deletion)) (PP (IN of) (NP (NP (DT the) (JJ complete) (JJ active-site) (NN [des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT1_) (-RRB- -RSB-)) (PP (IN within) (NP (DT the) (JJ catalytic) (NN domain)))))) (, ,) (CC or) (NP (NP (NN mutation)) (PP (IN of) (NP (NP (DT a) (JJ single) (NN His) (NN residue)) (PP (IN of) (NP (NP (DT the) (NN Zn2+) (NN binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN His199)) (-RRB- -RRB-))))))) (, ,)) (VP (VBZ generates) (NP (NP (JJ stable) (NNS forms)) (PP (IN of) (NP (NN _PROT2_) (NNS proteins))) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB digest) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC or) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Deletion)) (PP (IN of) (NP (NP (DT the) (JJ complete) (JJ active-site) (NN [des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT1_) (-RRB- -RSB-)) (PP (IN within) (NP (DT the) (JJ catalytic) (NN domain)))))) (, ,) (CC or) (NP (NP (NN mutation)) (PP (IN of) (NP (NP (DT a) (JJ single) (NN His) (NN residue)) (PP (IN of) (NP (NP (DT the) (NN Zn2+) (NN binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN His199)) (-RRB- -RRB-))))))) (, ,)) (VP (VBZ generates) (NP (NP (JJ stable) (NNS forms)) (PP (IN of) (NP (NN _PROT_) (NNS proteins))) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB digest) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC or) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Deletion)) (PP (IN of) (NP (NP (DT the) (JJ complete) (JJ active-site) (NN [des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT1_) (-RRB- -RSB-)) (PP (IN within) (NP (DT the) (JJ catalytic) (NN domain)))))) (, ,) (CC or) (NP (NP (NN mutation)) (PP (IN of) (NP (NP (DT a) (JJ single) (NN His) (NN residue)) (PP (IN of) (NP (NP (DT the) (NN Zn2+) (NN binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN His199)) (-RRB- -RRB-))))))) (, ,)) (VP (VBZ generates) (NP (NP (JJ stable) (NNS forms)) (PP (IN of) (NP (NN _PROT_) (NNS proteins))) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB digest) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC or) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Deletion)) (PP (IN of) (NP (NP (DT the) (JJ complete) (JJ active-site) (NN [des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT_) (-RRB- -RSB-)) (PP (IN within) (NP (DT the) (JJ catalytic) (NN domain)))))) (, ,) (CC or) (NP (NP (NN mutation)) (PP (IN of) (NP (NP (DT a) (JJ single) (NN His) (NN residue)) (PP (IN of) (NP (NP (DT the) (NN Zn2+) (NN binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN His199)) (-RRB- -RRB-))))))) (, ,)) (VP (VBZ generates) (NP (NP (JJ stable) (NNS forms)) (PP (IN of) (NP (NN _PROT1_) (NNS proteins))) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB digest) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC or) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Deletion)) (PP (IN of) (NP (NP (DT the) (JJ complete) (JJ active-site) (NN [des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT_) (-RRB- -RSB-)) (PP (IN within) (NP (DT the) (JJ catalytic) (NN domain)))))) (, ,) (CC or) (NP (NP (NN mutation)) (PP (IN of) (NP (NP (DT a) (JJ single) (NN His) (NN residue)) (PP (IN of) (NP (NP (DT the) (NN Zn2+) (NN binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN His199)) (-RRB- -RRB-))))))) (, ,)) (VP (VBZ generates) (NP (NP (JJ stable) (NNS forms)) (PP (IN of) (NP (NN _PROT1_) (NNS proteins))) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB digest) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC or) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Deletion)) (PP (IN of) (NP (NP (DT the) (JJ complete) (JJ active-site) (NN [des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT_) (-RRB- -RSB-)) (PP (IN within) (NP (DT the) (JJ catalytic) (NN domain)))))) (, ,) (CC or) (NP (NP (NN mutation)) (PP (IN of) (NP (NP (DT a) (JJ single) (NN His) (NN residue)) (PP (IN of) (NP (NP (DT the) (NN Zn2+) (NN binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN His199)) (-RRB- -RRB-))))))) (, ,)) (VP (VBZ generates) (NP (NP (JJ stable) (NNS forms)) (PP (IN of) (NP (NN _PROT_) (NNS proteins))) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB digest) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC or) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NN addition) (TO to) (NP (NN co-immunoprecipitation) (NN analysis))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN established) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (CC and) (ADJP (JJ sensitive))) (NN ELISA) (NN assay)) (VP (VBG using) (NP (JJ immobilized) (NN _PROT1_)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (JJ structural) (NNS requirements)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB form) (NP (NNS complexes)) (PP (IN with) (NP (PRP$ its) (NN inhibitor)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (RB Only) (DT the) (VBN activated) (CC and) (RB not) (DT the) (JJ latent) (NNS forms)) (PP (IN of) (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ C-terminal))) (JJ mutant) (NN des-) (-LRB- -LRB-) (NN 248-450) (-RRB- -RRB-) (NN _PROT1_) (NNS proteins)))) (VP (VBP are) (ADJP (JJ able) (S (VP (TO to) (VP (VB form) (NP (NP (NNS complexes)) (PP (IN with) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Neither) (NP (NP (NN mutation)) (PP (IN of) (NP (NN His199)))) (, ,) (CC nor) (NP (NP (NN deletion) (NNS mutants)) (NP (NP (NN des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT1_)) (CC and) (NP (NN des-) (-LRB- -LRB-) (CD 161-228/248-450) (-RRB- -RRB-) (NN _PROT2_)))) (, ,)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Neither) (NP (NP (NN mutation)) (PP (IN of) (NP (NN His199)))) (, ,) (CC nor) (NP (NP (NN deletion) (NNS mutants)) (NP (NP (NN des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT1_)) (CC and) (NP (NN des-) (-LRB- -LRB-) (CD 161-228/248-450) (-RRB- -RRB-) (NN _PROT_)))) (, ,)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Neither) (NP (NP (NN mutation)) (PP (IN of) (NP (NN His199)))) (, ,) (CC nor) (NP (NP (NN deletion) (NNS mutants)) (NP (NP (NN des-) (-LRB- -LRB-) (CD 161-228) (-RRB- -RRB-) (NN _PROT_)) (CC and) (NP (NN des-) (-LRB- -LRB-) (CD 161-228/248-450) (-RRB- -RRB-) (NN _PROT1_)))) (, ,)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (DT the) (JJ C-terminal) (NN hemopexin) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ corresponding) (NNS regions)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (DT the) (JJ C-terminal) (NN hemopexin) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ corresponding) (NNS regions)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))) (, ,) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (DT the) (JJ C-terminal) (NN hemopexin) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ corresponding) (NNS regions)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (DT the) (JJ C-terminal) (NN hemopexin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ corresponding) (NNS regions)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))) (, ,) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (DT the) (JJ C-terminal) (NN hemopexin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ corresponding) (NNS regions)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (DT the) (JJ C-terminal) (NN hemopexin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (PP (IN in) (NN contrast) (TO to) (NP (NP (DT the) (JJ corresponding) (NNS regions)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_)))))) (, ,) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NP (DT the) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN Zn2+))))))))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN complex) (NN formation)) (PP (IN with) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB further)) (VP (VBZ underlines) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (DT this) (NN region))) (PP (IN for) (NP (NP (JJ proper) (NN regulation)) (PP (IN of) (NP (NP (JJ enzymatic) (NN activity)) (PP (IN of) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NP (DT the) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN Zn2+))))))))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN complex) (NN formation)) (PP (IN with) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB further)) (VP (VBZ underlines) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (DT this) (NN region))) (PP (IN for) (NP (NP (JJ proper) (NN regulation)) (PP (IN of) (NP (NP (JJ enzymatic) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (NN integrity)) (PP (IN of) (NP (NP (DT the) (JJ catalytic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN Zn2+))))))))))) (VP (VBZ is) (ADVP (RB absolutely)) (VP (VBN required) (PP (IN for) (NP (NP (NN complex) (NN formation)) (PP (IN with) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB further)) (VP (VBZ underlines) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (DT this) (NN region))) (PP (IN for) (NP (NP (JJ proper) (NN regulation)) (PP (IN of) (NP (NP (JJ enzymatic) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Thymocyte) (NN activation)) (VP (VBZ induces) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Thymocyte) (NN activation)) (VP (VBZ induces) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Thymocyte) (NN activation)) (VP (VBZ induces) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Antibody-mediated) (NN cross-linking) (NNS studies)) (CC or) (NP (NNS studies))) (PP (IN on) (NP (NN _PROT1_) (JJ knockout) (NNS mice)))) (VP (VBP implicate) (NP (NN _PROT2_)) (PP (IN as) (NP (DT a) (JJ co-stimulatory) (CC or) (JJ negative) (JJ regulatory) (NN molecule))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Y429)) (CC and) (NP (NN Y441))) (VP (VBP occur) (PP (IN in) (NP (DT an) (JJ imperfect) (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (JJ -like) (NN sequence))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (JJ tyrosine-phosphorylated) (NNS _PROT2_)))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (VBG following) (NN T) (NN cell) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (JJ tyrosine-phosphorylated) (NNS _PROT_)))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_) (VBG following) (NN T) (NN cell) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (JJ tyrosine-phosphorylated) (NNS _PROT1_)))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_) (VBG following) (NN T) (NN cell) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (NN activity)) (CC and) (NP (NP (DT the) (JJ regulatory) (NN _PROT2_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD associated) (PP (IN with) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ pervanadate-stimulated))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ unstimulated) (NNS thymocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (NN activity)) (CC and) (NP (NP (DT the) (JJ regulatory) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))) (VP (VBD associated) (PP (IN with) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ pervanadate-stimulated))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ unstimulated) (NNS thymocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (NN activity)) (CC and) (NP (NP (DT the) (JJ regulatory) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD associated) (PP (IN with) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ pervanadate-stimulated))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ unstimulated) (NNS thymocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_) (NN _PROT_)) (NN activity)) (CC and) (NP (NP (DT the) (JJ regulatory) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))) (VP (VBD associated) (PP (IN with) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ pervanadate-stimulated))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ unstimulated) (NNS thymocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_) (NN _PROT_)) (NN activity)) (CC and) (NP (NP (DT the) (JJ regulatory) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD associated) (PP (IN with) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ pervanadate-stimulated))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ unstimulated) (NNS thymocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_) (NN _PROT_)) (NN activity)) (CC and) (NP (NP (DT the) (JJ regulatory) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VBD associated) (PP (IN with) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ pervanadate-stimulated))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ unstimulated) (NNS thymocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cellular) (NN _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ recombinant) (NN Src) (NN homology) (CD 2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NNS domains)) (PP (IN of) (NP (NN _PROT2_))))) (VP (VBD bound) (NP (NP (DT a) (JJ tyrosine-phosphorylated) (NN peptide)) (VP (VBG encompassing) (NP (NP (NN Y463)) (PP (IN with) (NP (NP (ADJP (RB approximately) (RB threefold) (JJR greater)) (NN affinity)) (PP (IN than) (NP (DT a) (ADJP (RB doubly) (JJ tyrosine-phosphorylated)) (NN Y429-Y441) (NN peptide)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBD associated) (PP (PP (IN with) (NP (NN _PROT_))) (CC and) (ADVP (RB specifically)) (PP (IN with) (NP (NP (DT the) (NN Y429-Y441) (NN phosphopeptide)) (PP (IN in) (NP (VBN stimulated) (NNS thymocytes)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD associated) (PP (PP (IN with) (NP (NN _PROT2_))) (CC and) (ADVP (RB specifically)) (PP (IN with) (NP (NP (DT the) (NN Y429-Y441) (NN phosphopeptide)) (PP (IN in) (NP (VBN stimulated) (NNS thymocytes)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD associated) (PP (PP (IN with) (NP (NN _PROT2_))) (CC and) (ADVP (RB specifically)) (PP (IN with) (NP (NP (DT the) (NN Y429-Y441) (NN phosphopeptide)) (PP (IN in) (NP (VBN stimulated) (NNS thymocytes)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (NNS thymocytes))) (PP (IN with) (NP (NN pervanadate)))) (VP (VBZ induces) (NP (NP (DT the) (NN recruitment)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (TO to) (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (NNS thymocytes))) (PP (IN with) (NP (NN pervanadate)))) (VP (VBZ induces) (NP (NP (DT the) (NN recruitment)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (NNS thymocytes))) (PP (IN with) (NP (NN pervanadate)))) (VP (VBZ induces) (NP (NP (DT the) (NN recruitment)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN As) (S (S (NP (NN _PROT1_)) (VP (VBZ forms) (NP (NP (NNS complexes)) (PP (IN with) (NP (NN beta) (CD 1) (NNS integrins)))))) (CC and) (S (NP (DT the) (NNS integrins)) (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB regulate) (NP (JJ keratinocyte) (NN behaviour)))))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (NP (VBN _PROT2_) (NP (NN expression)) (CC and) (NP (NN function))) (PP (IN in) (NP (JJ human) (JJ epidermal) (NNS keratinocytes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (EX There)) (VP (VBD was) (NP (NP (JJ extensive) (NN co-localisation)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN beta))) (CD 1) (NNS integrins))) (PP (PP (IN on) (NP (NN microvilli))) (CC and) (PP (IN at) (NP (NP (JJ cell-cell) (NNS borders)) (PP (IN of) (NP (JJ basal) (NNS keratinocytes))))))))) (: ;) (S (ADVP (RB however)) (, ,) (PP (IN in) (NP (NP (NN contrast)) (PP (TO to) (NP (DT the) (NNS integrins))))) (, ,) (NP (NN _PROT2_)) (VP (VBD was) (RB not) (VP (VBN found) (PP (IN in) (NP (JJ focal) (NNS adhesions)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN detected) (PP (PP (IN in) (NP (NP (NN beta) (CD 1) (NN integrin)) (NNS immunoprecipitates))) (CC and) (ADVP (RB also)) (PP (IN in) (NP (NP (NNS immunoprecipitates)) (PP (IN of) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (CONJP (CC but) (RB not)) (PP (IN of) (NP (NNS cadherins))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN detected) (PP (PP (IN in) (NP (NP (NN beta) (CD 1) (NN integrin)) (NNS immunoprecipitates))) (CC and) (ADVP (RB also)) (PP (IN in) (NP (NP (NNS immunoprecipitates)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (CONJP (CC but) (RB not)) (PP (IN of) (NP (NNS cadherins))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN detected) (PP (PP (IN in) (NP (NP (NN beta) (CD 1) (NN integrin)) (NNS immunoprecipitates))) (CC and) (ADVP (RB also)) (PP (IN in) (NP (NP (NNS immunoprecipitates)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (CONJP (CC but) (RB not)) (PP (IN of) (NP (NNS cadherins))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN alpha) (CD 3) (NN beta) (CD 1)) (CONJP (CC but) (RB not)) (NP (NN alpha) (CD 5) (NN beta) (CD 1))))))) (: ;) (S (NP (NP (JJ small) (NNS amounts)) (PP (IN of) (NP (NN _PROT2_)))) (ADVP (RB also)) (VP (VBN co-immunoprecipitated) (PP (IN with) (NP (NP (NNS antibodies)) (PP (TO to) (NP (NP (NN alpha) (CD 2) (NN beta) (CD 1)) (CC and) (NP (NN alpha) (CD 6) (NN beta) (CD 4)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBD did) (RB not) (VP (VB affect) (NP (NP (DT the) (NN proportion)) (PP (IN of) (NP (NP (NNS keratinocytes)) (SBAR (WHNP (WDT that)) (S (ADJP (JJ adhered) (PP (TO to) (NP (NP (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NN _PROT_) (CD _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (, ,) (CC but) (VP (VBD did) (VP (VB inhibit) (NP (NP (NN motility)) (PP (IN of) (NP (NNS keratinocytes))) (PP (IN on) (NP (NN tissue) (NN culture) (NN plastic)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBD did) (RB not) (VP (VB affect) (NP (NP (DT the) (NN proportion)) (PP (IN of) (NP (NP (NNS keratinocytes)) (SBAR (WHNP (WDT that)) (S (ADJP (JJ adhered) (PP (TO to) (NP (NP (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (, ,) (CC but) (VP (VBD did) (VP (VB inhibit) (NP (NP (NN motility)) (PP (IN of) (NP (NNS keratinocytes))) (PP (IN on) (NP (NN tissue) (NN culture) (NN plastic)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBD did) (RB not) (VP (VB affect) (NP (NP (DT the) (NN proportion)) (PP (IN of) (NP (NP (NNS keratinocytes)) (SBAR (WHNP (WDT that)) (S (ADJP (JJ adhered) (PP (TO to) (NP (NP (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_) (CD _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (, ,) (CC but) (VP (VBD did) (VP (VB inhibit) (NP (NP (NN motility)) (PP (IN of) (NP (NNS keratinocytes))) (PP (IN on) (NP (NN tissue) (NN culture) (NN plastic)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBD did) (RB not) (VP (VB affect) (NP (NP (DT the) (NN proportion)) (PP (IN of) (NP (NP (NNS keratinocytes)) (SBAR (WHNP (WDT that)) (S (ADJP (JJ adhered) (PP (TO to) (NP (NP (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (, ,) (CC but) (VP (VBD did) (VP (VB inhibit) (NP (NP (NN motility)) (PP (IN of) (NP (NNS keratinocytes))) (PP (IN on) (NP (NN tissue) (NN culture) (NN plastic)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBD did) (RB not) (VP (VB affect) (NP (NP (DT the) (NN proportion)) (PP (IN of) (NP (NP (NNS keratinocytes)) (SBAR (WHNP (WDT that)) (S (ADJP (JJ adhered) (PP (TO to) (NP (NP (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_) (CD _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (, ,) (CC but) (VP (VBD did) (VP (VB inhibit) (NP (NP (NN motility)) (PP (IN of) (NP (NNS keratinocytes))) (PP (IN on) (NP (NN tissue) (NN culture) (NN plastic)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBD did) (RB not) (VP (VB affect) (NP (NP (DT the) (NN proportion)) (PP (IN of) (NP (NP (NNS keratinocytes)) (SBAR (WHNP (WDT that)) (S (ADJP (JJ adhered) (PP (TO to) (NP (NP (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))) (, ,) (CC but) (VP (VBD did) (VP (VB inhibit) (NP (NP (NN motility)) (PP (IN of) (NP (NNS keratinocytes))) (PP (IN on) (NP (NN tissue) (NN culture) (NN plastic)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Like) (NP (NP (NNS antibodies)) (PP (TO to) (NP (DT the) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN subunit))))) (, ,) (NP (NN _PROT2_)) (VP (VBD inhibited) (NP (JJ suspension-induced) (JJ terminal) (NN differentiation)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Human) (NN _PROT1_)) (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NNS properties)) (PP (IN of) (NP (PRP$ its) (JJ carboxyl-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Human) (NN _PROT1_)) (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NNS properties)) (PP (IN of) (NP (PRP$ its) (JJ carboxyl-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Human) (NN _PROT_)) (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NNS properties)) (PP (IN of) (NP (PRP$ its) (JJ carboxyl-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP show) (SBAR (IN that) (S (NP (JJ full-length) (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (VBN activated) (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))) (CC and) (VP (VBZ defines) (NP (NP (DT a) (JJ minimum) (NN region)) (PP (IN of) (NP (CD 434) (NN aa))) (VP (VBN required) (PP (IN for) (NP (JJ efficient) (NN _PROT_) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP show) (SBAR (IN that) (S (NP (JJ full-length) (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (VBN activated) (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))) (CC and) (VP (VBZ defines) (NP (NP (DT a) (JJ minimum) (NN region)) (PP (IN of) (NP (CD 434) (NN aa))) (VP (VBN required) (PP (IN for) (NP (JJ efficient) (NN _PROT2_) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP show) (SBAR (IN that) (S (NP (JJ full-length) (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (VBN activated) (NN _PROT1_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))) (CC and) (VP (VBZ defines) (NP (NP (DT a) (JJ minimum) (NN region)) (PP (IN of) (NP (CD 434) (NN aa))) (VP (VBN required) (PP (IN for) (NP (JJ efficient) (NN _PROT2_) (NN binding))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (NN _PROT_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT2_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (NN _PROT_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ known) (NN _PROT_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (NN _PROT2_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT2_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (NN _PROT_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ known) (NN _PROT_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (NN _PROT2_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT1_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ known) (NN _PROT_) (NN effector)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT1_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (NN _PROT2_) (NN effector)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (`` ``) (NN effector) (NN domain) (NN '')) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ employs) (NP (NP (NP (NP (DT some) (NN _PROT_) (NNS determinants)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ common) (PP (TO to))))))) (, ,) (CC and) (NP (NP (NNS others)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from)))))))) (, ,) (NP (NP (DT those)) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ known) (NN _PROT2_) (NN effector)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ same) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT2_)))))) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))) (, ,) (S (VP (VBG extending) (NP (NP (DT the) (NN similarity)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (JJ other) (NN _PROT_) (NNS effectors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ same) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT_)))))) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))) (, ,) (S (VP (VBG extending) (NP (NP (DT the) (NN similarity)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ other) (NN _PROT_) (NNS effectors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ same) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT_)))))) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))) (, ,) (S (VP (VBG extending) (NP (NP (DT the) (NN similarity)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (JJ other) (NN _PROT2_) (NNS effectors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ same) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT1_)))))) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))) (, ,) (S (VP (VBG extending) (NP (NP (DT the) (NN similarity)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ other) (NN _PROT_) (NNS effectors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ same) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT1_)))))) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))) (, ,) (S (VP (VBG extending) (NP (NP (DT the) (NN similarity)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (JJ other) (NN _PROT2_) (NNS effectors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ same) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT_)))))) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))) (, ,) (S (VP (VBG extending) (NP (NP (DT the) (NN similarity)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ other) (NN _PROT2_) (NNS effectors))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN binding) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (MD can) (VP (VB act) (PP (IN as) (NP (DT a) (ADJP (ADJP (JJ dominant)) (ADJP (JJ negative))) (NN signal) (NN transduction) (NN blocker)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN sequence)) (VP (VBZ shows) (NP (NP (JJ preferential) (NN binding)) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN domain)))) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (ADVP (RB directly)) (VP (VP (VBZ associates) (PP (IN with))) (, ,) (CC and) (VP (VBZ is) (ADJP (NN tyrosine) (JJ phosphorylated) (PP (IN by) (NP (, ,) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Genetic) (NN profile)) (PP (IN of) (NP (CD 22) (JJ pancreatic) (NN carcinoma) (NN cell) (NNS lines.)))) (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS genes)) (VP (VBP are) (PP (IN among) (NP (NP (DT those)) (VP (ADVP (RBS most) (RB frequently)) (VBN altered) (PP (IN in) (NP (JJ pancreatic) (JJ ductal) (NN carcinoma)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS genes)) (VP (VBP are) (PP (IN among) (NP (NP (DT those)) (VP (ADVP (RBS most) (RB frequently)) (VBN altered) (PP (IN in) (NP (JJ pancreatic) (JJ ductal) (NN carcinoma)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS genes)) (VP (VBP are) (PP (IN among) (NP (NP (DT those)) (VP (ADVP (RBS most) (RB frequently)) (VBN altered) (PP (IN in) (NP (JJ pancreatic) (JJ ductal) (NN carcinoma)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS genes)) (VP (VBP are) (PP (IN among) (NP (NP (DT those)) (VP (ADVP (RBS most) (RB frequently)) (VBN altered) (PP (IN in) (NP (JJ pancreatic) (JJ ductal) (NN carcinoma)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS genes)) (VP (VBP are) (PP (IN among) (NP (NP (DT those)) (VP (ADVP (RBS most) (RB frequently)) (VBN altered) (PP (IN in) (NP (JJ pancreatic) (JJ ductal) (NN carcinoma)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS genes)) (VP (VBP are) (PP (IN among) (NP (NP (DT those)) (VP (ADVP (RBS most) (RB frequently)) (VBN altered) (PP (IN in) (NP (JJ pancreatic) (JJ ductal) (NN carcinoma)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NN cell) (NNS lines)) (VP (VBD showed) (NP (NP (NNS mutations)) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN at) (NP (NP (NNS frequencies)) (PP (IN of) (NP (NP (CD 91) (NN %)) (CC and) (NP (CD 95) (NN %)) (, ,) (ADVP (RB respectively)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (ADJP (RBS most) (JJ typical)) (JJ mutational) (NN profile)) (VP (VBD involved) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)) (, ,) (ADVP (RB concurrently)) (VP (VBN aberrated) (PP (IN in) (NP (NP (CD 20) (NNS cases)) (PRN (-LRB- -LRB-) (NP (CD 91) (NN %)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (ADJP (RBS most) (JJ typical)) (JJ mutational) (NN profile)) (VP (VBD involved) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)) (, ,) (ADVP (RB concurrently)) (VP (VBN aberrated) (PP (IN in) (NP (NP (CD 20) (NNS cases)) (PRN (-LRB- -LRB-) (NP (CD 91) (NN %)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (ADJP (RBS most) (JJ typical)) (JJ mutational) (NN profile)) (VP (VBD involved) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)) (, ,) (ADVP (RB concurrently)) (VP (VBN aberrated) (PP (IN in) (NP (NP (CD 20) (NNS cases)) (PRN (-LRB- -LRB-) (NP (CD 91) (NN %)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN binding) (NN domain))) (PP (IN on) (NP (NP (DT the) (JJ human) (NN _PROT2_) (NN molecule)) (VP (VBG using) (NP (NN _PROT_) (NNS antibodies))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN binding) (NN domain))) (PP (IN on) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN molecule)) (VP (VBG using) (NP (NN _PROT2_) (NNS antibodies))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN binding) (NN domain))) (PP (IN on) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN molecule)) (VP (VBG using) (NP (NN _PROT2_) (NNS antibodies))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (PRP$ its) (NN counter-receptor) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (VP (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN superfamily))))) (CC and) (VP (VBP function) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN lymphocyte) (NN survival)) (CC and) (NP (NN differentiation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_AND_PROT2_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT2_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT2_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT1_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT1_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT1_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (DT a) (JJ soluble) (NN _PROT_) (JJ chimeric) (NN protein)))) (, ,) (NP (PRP we)) (VP (VBD assessed) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB inhibit) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN by) (NP (DT the) (JJ CD30+) (NN Karpas) (NN 299) (NN cell) (NN line)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN binding)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN MAb)) (SBAR (WHNP (WDT that)) (S (VP (VBP recognize) (NP (NP (NNS epitopes)) (VP (VBG belonging) (PP (TO to) (NP (NP (NP (NN cluster) (NN Group) (NN A)) (PRN (-LRB- -LRB-) (PP (IN like) (NP (NP (NN Ber-H2)) (, ,) (NP (NN Ber-H8)) (, ,) (CC and) (NP (NN HRS-4)))) (-RRB- -RRB-))) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN cluster) (NN Group) (NN C)) (PRN (-LRB- -LRB-) (PP (IN like) (NP (NP (NN HeFi-1)) (CC and) (NP (NN M44)))) (-RRB- -RRB-))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Cluster) (NN Group) (NN B) (NNS antibodies)) (, ,) (PP (VBG including) (NP (NP (NN M67)) (CC and) (NP (NN Ki-1)))) (, ,)) (VP (VBP do) (RB not) (VP (VB affect) (NP (NP (NN _PROT1_) (NN binding)) (PP (TO to) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN pattern)) (PP (IN of) (NP (NN _PROT1_) (NN binding) (NN inhibition)))) (VP (VBZ shows) (NP (NP (ADJP (RB only) (JJ limited)) (NN correspondence)) (PP (TO to) (NP (NP (DT the) (JJ functional) (NN capacity)) (PP (IN of) (NP (DT some) (CD _PROT2_) (NN MAb))) (S (VP (TO to) (VP (VB trigger) (NP (NN _PROT_) (NN signaling))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN pattern)) (PP (IN of) (NP (NN _PROT1_) (NN binding) (NN inhibition)))) (VP (VBZ shows) (NP (NP (ADJP (RB only) (JJ limited)) (NN correspondence)) (PP (TO to) (NP (NP (DT the) (JJ functional) (NN capacity)) (PP (IN of) (NP (DT some) (CD _PROT_) (NN MAb))) (S (VP (TO to) (VP (VB trigger) (NP (NN _PROT2_) (NN signaling))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN pattern)) (PP (IN of) (NP (NN _PROT_) (NN binding) (NN inhibition)))) (VP (VBZ shows) (NP (NP (ADJP (RB only) (JJ limited)) (NN correspondence)) (PP (TO to) (NP (NP (DT the) (JJ functional) (NN capacity)) (PP (IN of) (NP (DT some) (CD _PROT1_) (NN MAb))) (S (VP (TO to) (VP (VB trigger) (NP (NN _PROT2_) (NN signaling))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (JJ _PROT1_) (NN MAb) (NN M81)) (ADVP (RB also)) (ADVP (RB completely)) (VP (VBZ inhibits) (NP (NN _PROT2_) (NN interaction)))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (JJ _PROT1_) (NN MAb) (NN M81)) (ADVP (RB also)) (ADVP (RB completely)) (VP (VBZ inhibits) (NP (NN _PROT2_) (NN interaction)))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (JJ _PROT_) (NN MAb) (NN M81)) (ADVP (RB also)) (ADVP (RB completely)) (VP (VBZ inhibits) (NP (NN _PROT1_AND_PROT2_) (NN interaction)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN information)) (VP (VBZ is) (ADJP (JJ useful) (PP (PP (IN for) (S (VP (VBG applying) (NP (DT these) (NNS MAbs)) (PP (IN in) (NP (JJ functional) (NNS studies) (S (VP (TO to) (ADVP (RB further)) (VP (VB investigate) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN system)))))))))) (CC and) (PP (IN for) (S (VP (VBG designing) (NP (NNS assays)) (PP (IN for) (NP (JJ soluble) (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN information)) (VP (VBZ is) (ADJP (JJ useful) (PP (PP (IN for) (S (VP (VBG applying) (NP (DT these) (NNS MAbs)) (PP (IN in) (NP (JJ functional) (NNS studies) (S (VP (TO to) (ADVP (RB further)) (VP (VB investigate) (NP (DT the) (NN _PROT1_) (NN system)))))))))) (CC and) (PP (IN for) (S (VP (VBG designing) (NP (NNS assays)) (PP (IN for) (NP (JJ soluble) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN information)) (VP (VBZ is) (ADJP (JJ useful) (PP (PP (IN for) (S (VP (VBG applying) (NP (DT these) (NNS MAbs)) (PP (IN in) (NP (JJ functional) (NNS studies) (S (VP (TO to) (ADVP (RB further)) (VP (VB investigate) (NP (DT the) (NN _PROT1_) (NN system)))))))))) (CC and) (PP (IN for) (S (VP (VBG designing) (NP (NNS assays)) (PP (IN for) (NP (JJ soluble) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VP (VBN isolated)) (CC and) (VP (VBN characterized) (NP (NP (NP (DT a) (NN cDNA) (NN clone)) (, ,) (NP (NN _PROT1_)) (, ,)) (VP (VBG encoding) (NP (NP (DT a) (NP (NP (JJ human) (NN fibroblast) (NN growth) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN FGF)) (-RRB- -RRB-))) (NN receptor.) (NN _PROT2_)) (VP (VBZ contains) (NP (NP (DT an) (JJ open) (NN reading) (NN frame)) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (DT an) (CD 820) (NN amino) (NN acid) (NN polypeptide)) (PP (IN with) (NP (NP (NP (CD three) (JJ immunoglobulin-like) (NNS domains)) (PP (IN in) (NP (DT the) (JJ extracellular) (NN part)))) (CC and) (NP (DT an) (JJ intracellular) (JJ split) (NN tyrosine) (NN kinase) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Transient) (NN expression)) (PP (IN in) (NP (NP (NN COS-1) (NNS cells)) (CC and) (NP (NP (NN immunoprecipitation)) (VP (VBG using) (NP (NP (DT an) (NN antiserum)) (VP (VBN raised) (PP (IN against) (NP (DT a) (JJ C-terminal) (NN peptide))))))))) (, ,)) (VP (VBD gave) (NP (NN rise)) (PP (TO to) (NP (CD two) (NNS components))) (, ,) (S (VP (VBG representing) (NP (NP (JJ mature) (PRN (-LRB- -LRB-) (NP (CD 130) (NN kDa)) (-RRB- -RRB-)) (CC and) (NN precursor) (PRN (-LRB- -LRB-) (NP (CD 115) (NN kDa)) (-RRB- -RRB-)) (NNS forms)) (PP (IN of) (NP (NP (DT the) (ADJP (NN _PROT1_) (VBN encoded)) (NN polypeptide)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN denoted) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NP (NP (JJ iodinated) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (TO to) (NP (RB transiently) (VBG expressing) (NN COS-1) (NNS cells)))) (VP (VBD revealed) (NP (NP (DT a) (JJ major) (NN band)) (PP (IN of) (NP (NP (CD 95) (NN kDa)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (VP (VBN competed) (PRT (IN for)) (PP (IN by) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN From) (NP (NN Scatchard) (NNS analyses))) (, ,) (NP (NP (DT the) (ADJP (NP (NN Kd)) (: :)) (NN s)) (PP (IN for) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (TO to) (NP (NN _PROT_)))))) (VP (VBD were) (VP (VBN estimated) (PP (TO to) (NP (NP (CD 25) (NN pM)) (CC and) (NP (CD 41) (NN pM)))) (, ,) (ADVP (RB respectively))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN From) (NP (NN Scatchard) (NNS analyses))) (, ,) (NP (NP (DT the) (ADJP (NP (NN Kd)) (: :)) (NN s)) (PP (IN for) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT2_)))))) (VP (VBD were) (VP (VBN estimated) (PP (TO to) (NP (NP (CD 25) (NN pM)) (CC and) (NP (CD 41) (NN pM)))) (, ,) (ADVP (RB respectively))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN From) (NP (NN Scatchard) (NNS analyses))) (, ,) (NP (NP (DT the) (ADJP (NP (NN Kd)) (: :)) (NN s)) (PP (IN for) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT2_)))))) (VP (VBD were) (VP (VBN estimated) (PP (TO to) (NP (NP (CD 25) (NN pM)) (CC and) (NP (CD 41) (NN pM)))) (, ,) (ADVP (RB respectively))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ human) (NN FGF) (NN receptor)) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ human) (NN FGF) (NN receptor)) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ human) (NN FGF) (NN receptor)) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN dimerization)) (PP (IN of) (NP (NP (NN transcription) (NNS factors)) (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBZ alters) (NP (NN DNA) (NN binding) (NN specificity)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN dimerization)) (PP (IN of) (NP (NP (NN transcription) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBZ alters) (NP (NN DNA) (NN binding) (NN specificity)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN dimerization)) (PP (IN of) (NP (NP (NN transcription) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBZ alters) (NP (NN DNA) (NN binding) (NN specificity)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN dimerization)) (PP (IN of) (NP (NP (NN transcription) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBZ alters) (NP (NN DNA) (NN binding) (NN specificity)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN dimerization)) (PP (IN of) (NP (NP (NN transcription) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBZ alters) (NP (NN DNA) (NN binding) (NN specificity)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN dimerization)) (PP (IN of) (NP (NP (NN transcription) (NNS factors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_)))))) (VP (VBZ alters) (NP (NN DNA) (NN binding) (NN specificity)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_AND_PROT2_) (CC and) (NN _PROT_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP function) (PP (IN in) (NP (NP (NN coupling) (JJ extracellular) (NNS signals)) (PP (TO to) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (JJ specific) (NN target) (NNS genes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP function) (PP (IN in) (NP (NP (NN coupling) (JJ extracellular) (NNS signals)) (PP (TO to) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (JJ specific) (NN target) (NNS genes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP function) (PP (IN in) (NP (NP (NN coupling) (JJ extracellular) (NNS signals)) (PP (TO to) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (JJ specific) (NN target) (NNS genes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP function) (PP (IN in) (NP (NP (NN coupling) (JJ extracellular) (NNS signals)) (PP (TO to) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (JJ specific) (NN target) (NNS genes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP function) (PP (IN in) (NP (NP (NN coupling) (JJ extracellular) (NNS signals)) (PP (TO to) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (JJ specific) (NN target) (NNS genes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (CC and) (NN _PROT1_AND_PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP function) (PP (IN in) (NP (NP (NN coupling) (JJ extracellular) (NNS signals)) (PP (TO to) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (JJ specific) (NN target) (NNS genes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADVP (RB previously)) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (ADVP (RB preferentially)) (PP (IN with) (NP (NP (JJ different) (NN DNA) (JJ regulatory) (NNS elements)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (NN AP-1/TRE)) (CC and) (NP (NN ATF/CRE))) (NNS sites)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))))))))))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (CD two) (NNS families)))) (VP (VBP form) (NP (JJ selective) (JJ cross-family) (NNS heterodimers)))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB previously)) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (ADVP (RB preferentially)) (PP (IN with) (NP (NP (JJ different) (NN DNA) (JJ regulatory) (NNS elements)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (NN AP-1/TRE)) (CC and) (NP (NN ATF/CRE))) (NNS sites)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))))))))))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (CD two) (NNS families)))) (VP (VBP form) (NP (JJ selective) (JJ cross-family) (NNS heterodimers)))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB previously)) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (ADVP (RB preferentially)) (PP (IN with) (NP (NP (JJ different) (NN DNA) (JJ regulatory) (NNS elements)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (NN AP-1/TRE)) (CC and) (NP (NN ATF/CRE))) (NNS sites)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))))))))))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (CD two) (NNS families)))) (VP (VBP form) (NP (JJ selective) (JJ cross-family) (NNS heterodimers)))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB previously)) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (ADVP (RB preferentially)) (PP (IN with) (NP (NP (JJ different) (NN DNA) (JJ regulatory) (NNS elements)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (NN AP-1/TRE)) (CC and) (NP (NN ATF/CRE))) (NNS sites)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))))))))))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (CD two) (NNS families)))) (VP (VBP form) (NP (JJ selective) (JJ cross-family) (NNS heterodimers)))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB previously)) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (ADVP (RB preferentially)) (PP (IN with) (NP (NP (JJ different) (NN DNA) (JJ regulatory) (NNS elements)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (NN AP-1/TRE)) (CC and) (NP (NN ATF/CRE))) (NNS sites)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))))))))))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (CD two) (NNS families)))) (VP (VBP form) (NP (JJ selective) (JJ cross-family) (NNS heterodimers)))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))) (VP (VBD were) (ADVP (RB previously)) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (ADVP (RB preferentially)) (PP (IN with) (NP (NP (JJ different) (NN DNA) (JJ regulatory) (NNS elements)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (NN AP-1/TRE)) (CC and) (NP (NN ATF/CRE))) (NNS sites)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))))))))))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (CD two) (NNS families)))) (VP (VBP form) (NP (JJ selective) (JJ cross-family) (NNS heterodimers)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (CC and) (NN _PROT_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP are) (RB not) (ADJP (RB as) (JJ distinct)) (SBAR (IN as) (S (VP (VBD was) (ADVP (RB previously)) (VP (VBN thought)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP are) (RB not) (ADJP (RB as) (JJ distinct)) (SBAR (IN as) (S (VP (VBD was) (ADVP (RB previously)) (VP (VBN thought)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP are) (RB not) (ADJP (RB as) (JJ distinct)) (SBAR (IN as) (S (VP (VBD was) (ADVP (RB previously)) (VP (VBN thought)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP are) (RB not) (ADJP (RB as) (JJ distinct)) (SBAR (IN as) (S (VP (VBD was) (ADVP (RB previously)) (VP (VBN thought)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP are) (RB not) (ADJP (RB as) (JJ distinct)) (SBAR (IN as) (S (VP (VBD was) (ADVP (RB previously)) (VP (VBN thought)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT1_AND_PROT2_) (NNS families)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBP are) (RB not) (ADJP (RB as) (JJ distinct)) (SBAR (IN as) (S (VP (VBD was) (ADVP (RB previously)) (VP (VBN thought)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (PP (IN with) (NP (JJ _PROT_) (NNS proteins)))) (VP (VBZ occurs) (PP (IN through) (NP (DT an) (JJ amphipathic) (NN helix) (NN binding) (NN motif))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (JJ _PROT2_) (NNS proteins)))) (VP (VBZ occurs) (PP (IN through) (NP (DT an) (JJ amphipathic) (NN helix) (NN binding) (NN motif))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (JJ _PROT2_) (NNS proteins)))) (VP (VBZ occurs) (PP (IN through) (NP (DT an) (JJ amphipathic) (NN helix) (NN binding) (NN motif))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CD _PROT1_) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBZ is) (VP (JJ localized) (PP (TO to) (NP (JJ specific) (JJ subcellular) (NNS environments))) (PP (IN through) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT the) (NP (NP (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN dimer))) (PP (TO to) (NP (JJ _PROT_) (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CD _PROT1_) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBZ is) (VP (JJ localized) (PP (TO to) (NP (JJ specific) (JJ subcellular) (NNS environments))) (PP (IN through) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT the) (NP (NP (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN dimer))) (PP (TO to) (NP (JJ _PROT2_) (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CD _PROT_) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBZ is) (VP (JJ localized) (PP (TO to) (NP (JJ specific) (JJ subcellular) (NNS environments))) (PP (IN through) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT the) (NP (NP (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN dimer))) (PP (TO to) (NP (JJ _PROT2_) (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT1_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT_)) (NP (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT1_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT_)) (NP (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT1_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT2_)) (NP (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT1_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT_)) (NP (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT2_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT_)) (NP (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT2_)) (NP (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT_)) (NP (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT2_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT2_)) (NP (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT_)) (NP (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT2_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Computer-aided) (NN analysis)) (PP (IN of) (NP (JJ secondary) (NN structure))) (, ,) (VP (VBN performed) (PP (IN on) (NP (NP (CD four) (JJ _PROT_) (NN protein) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD two) (NN thyroid) (NNS proteins))) (NN _PROT1_)) (NP (NP (CD _PROT1_)) (CC and) (NP (NN _PROT2_) (CD _PROT2_)))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ has) (VP (VBN identified) (NP (NP (JJ common) (NNS regions)) (PP (IN of) (NP (QP (RB approximately) (CD 14)) (NNS residues))) (SBAR (WHNP (WDT which)) (S (VP (VBP display) (NP (NP (JJ high) (NNS probabilities)) (PP (IN of) (S (VP (VBG forming) (NP (JJ amphipathic) (NNS helices))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT A) (ADJP (RB bacterially) (VBN expressed)) (NN 318-amino) (NN acid) (NN fragment)) (, ,) (NP (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (CD 418-736) (-RRB- -RRB-))) (, ,) (VP (VBG containing) (NP (DT the) (JJ amphipathic) (NN helix) (NN region))) (, ,)) (VP (VBD was) (ADJP (JJ able) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT A) (ADJP (RB bacterially) (VBN expressed)) (NN 318-amino) (NN acid) (NN fragment)) (, ,) (NP (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (CD 418-736) (-RRB- -RRB-))) (, ,) (VP (VBG containing) (NP (DT the) (JJ amphipathic) (NN helix) (NN region))) (, ,)) (VP (VBD was) (ADJP (JJ able) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT A) (ADJP (RB bacterially) (VBN expressed)) (NN 318-amino) (NN acid) (NN fragment)) (, ,) (NP (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (CD 418-736) (-RRB- -RRB-))) (, ,) (VP (VBG containing) (NP (DT the) (JJ amphipathic) (NN helix) (NN region))) (, ,)) (VP (VBD was) (ADJP (JJ able) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Specifically)) (, ,) (NP (NP (NN substitution)) (PP (IN of) (NP (NN proline))) (PP (IN for) (NP (NN Ala-498)))) (ADVP (RB significantly)) (VP (VBD diminished) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN binding)))) (, ,) (CC and) (S (NP (NP (JJ similar) (NN mutation)) (PP (IN of) (NP (NP (NN Ile-502)) (CC or) (NP (NN Ile-507))))) (VP (VBD abolished) (NP (NN interaction))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutation)) (PP (IN of) (NP (NN Ala-522))) (PP (TO to) (NP (NN proline))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ located) (PP (IN outside) (NP (DT the) (VBN predicted) (JJ amphipathic) (NN helix) (NN region))))))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN binding))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN anchoring) (NNS proteins)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (PP (IN via) (NP (DT an) (JJ amphipathic) (NN helix) (NN binding) (NN motif)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN proto-oncogene) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN transcription) (NN factor) (NN family)) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN mediation)) (PP (IN of) (NP (NP (JJ nuclear) (NNS events)) (VP (VBN elicited) (PP (IN by) (NP (JJ extracellular) (NNS stimuli)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (NP (NN evidence) (SBAR (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBP phosphorylate) (NP (DT these) (NNS sites))))) (CC and) (SBAR (IN that) (S (NP (PRP$ their) (NN phosphorylation)) (ADVP (RB positively)) (VP (VBZ regulates) (NP (NP (DT the) (VBG transacting) (NN activity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (NP (NN evidence) (SBAR (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBP phosphorylate) (NP (DT these) (NNS sites))))) (CC and) (SBAR (IN that) (S (NP (PRP$ their) (NN phosphorylation)) (ADVP (RB positively)) (VP (VBZ regulates) (NP (NP (DT the) (VBG transacting) (NN activity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (NP (NN evidence) (SBAR (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBP phosphorylate) (NP (DT these) (NNS sites))))) (CC and) (SBAR (IN that) (S (NP (PRP$ their) (NN phosphorylation)) (ADVP (RB positively)) (VP (VBZ regulates) (NP (NP (DT the) (VBG transacting) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (NP (NN evidence) (SBAR (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBP phosphorylate) (NP (DT these) (NNS sites))))) (CC and) (SBAR (IN that) (S (NP (PRP$ their) (NN phosphorylation)) (ADVP (RB positively)) (VP (VBZ regulates) (NP (NP (DT the) (VBG transacting) (NN activity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (NP (NN evidence) (SBAR (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBP phosphorylate) (NP (DT these) (NNS sites))))) (CC and) (SBAR (IN that) (S (NP (PRP$ their) (NN phosphorylation)) (ADVP (RB positively)) (VP (VBZ regulates) (NP (NP (DT the) (VBG transacting) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (NP (NN evidence) (SBAR (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBP phosphorylate) (NP (DT these) (NNS sites))))) (CC and) (SBAR (IN that) (S (NP (PRP$ their) (NN phosphorylation)) (ADVP (RB positively)) (VP (VBZ regulates) (NP (NP (DT the) (VBG transacting) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NNS enzymes)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (NP (NN tyrosine)) (CONJP (RB as) (RB well) (IN as)) (NP (NN serine/threonine) (NN phosphorylation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NNS enzymes)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (NP (NN tyrosine)) (CONJP (RB as) (RB well) (IN as)) (NP (NN serine/threonine) (NN phosphorylation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN _PROT_) (NNS enzymes)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (NP (NN tyrosine)) (CONJP (RB as) (RB well) (IN as)) (NP (NN serine/threonine) (NN phosphorylation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))) (VP (MD may) (VP (VB underlie) (NP (NP (DT the) (JJ common) (NN stimulation)) (PP (IN of) (NP (DT this) (NN transcription) (NN factor))) (PP (IN by) (NP (NP (NNS mitogens)) (, ,) (NP (NN growth) (NNS factors)) (CC and) (NP (NNS oncogenes)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN T-cell) (NN antigen) (NN _PROT1_)) (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (NN receptor) (CC and) (NN substrate)) (PP (IN for) (NP (DT the) (NN protein-tyrosine) (NN kinase) (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ T-cell-specific) (NN antigen)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN B-cell) (NN antigen) (NN _PROT2_)))) (CC and) (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (NN coreceptor)) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN T-cell) (NN growth)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT1_AND_PROT2_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT1_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT1_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT_) (NN _PROT2_) (NN ligation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_) (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN complex)))) (CC and) (VP (VBZ is) (ADVP (RB rapidly)) (VP (VBN phosphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN ligation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN coupled) (PP (TO to) (NP (DT the) (NP (NN protein-tyrosine) (NN kinase)) (NP (NN _PROT2_)))))) (CC and) (VP (MD can) (VP (VB act) (PP (IN as) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN coupled) (PP (TO to) (NP (DT the) (NP (NN protein-tyrosine) (NN kinase)) (NP (NN _PROT_)))))) (CC and) (VP (MD can) (VP (VB act) (PP (IN as) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ is) (VP (VBN coupled) (PP (TO to) (NP (DT the) (NP (NN protein-tyrosine) (NN kinase)) (NP (NN _PROT1_)))))) (CC and) (VP (MD can) (VP (VB act) (PP (IN as) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (JJ baculovirus) (NN expression) (NN system)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NN tyrosine) (NNS residues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (JJ baculovirus) (NN expression) (NN system)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN on) (NP (NN tyrosine) (NNS residues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (JJ baculovirus) (NN expression) (NN system)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN on) (NP (NN tyrosine) (NNS residues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Further)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD coprecipitated) (NP (DT each) (JJ other)) (PP (IN in) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NNS detergents))) (, ,) (PP (VBG including) (NP (NP (NN Nonidet) (NN P-40)) (CC and) (NP (NN Triton) (NN X-100)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD precipitated) (NP (DT the) (NN kinase)) (PP (IN from) (NP (NP (JJ various) (NN T) (NNS cells)) (ADJP (JJ irrespective) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD precipitated) (NP (DT the) (NN kinase)) (PP (IN from) (NP (NP (JJ various) (NN T) (NNS cells)) (ADJP (JJ irrespective) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT_) (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD precipitated) (NP (DT the) (NN kinase)) (PP (IN from) (NP (NP (JJ various) (NN T) (NNS cells)) (ADJP (JJ irrespective) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT_) (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD precipitated) (NP (DT the) (NN kinase)) (PP (IN from) (NP (NP (JJ various) (NN T) (NNS cells)) (ADJP (JJ irrespective) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT1_) (NP (NN _PROT1_AND_PROT2_)) (CC or) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD precipitated) (NP (DT the) (NN kinase)) (PP (IN from) (NP (NP (JJ various) (NN T) (NNS cells)) (ADJP (JJ irrespective) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT1_) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD precipitated) (NP (DT the) (NN kinase)) (PP (IN from) (NP (NP (JJ various) (NN T) (NNS cells)) (ADJP (JJ irrespective) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT_) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT No) (NN binding)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN T)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NN T) (NNS cells)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VBD induced) (NP (NP (DT a) (ADJP (CD 10-) (TO to) (JJ 15-fold)) (NN increase)) (PP (IN in) (NP (NN _PROT_) (JJ catalytic) (NN activity)))) (, ,) (SBAR (IN as) (S (VP (VBN measured) (PP (IN by) (NP (ADJP (FW in) (FW vitro)) (NN kinase) (NN analysis)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_)))) (VP (VBD induced) (NP (NP (DT a) (ADJP (CD 10-) (TO to) (JJ 15-fold)) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (JJ catalytic) (NN activity)))) (, ,) (SBAR (IN as) (S (VP (VBN measured) (PP (IN by) (NP (ADJP (FW in) (FW vitro)) (NN kinase) (NN analysis)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_)))) (VP (VBD induced) (NP (NP (DT a) (ADJP (CD 10-) (TO to) (JJ 15-fold)) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (JJ catalytic) (NN activity)))) (, ,) (SBAR (IN as) (S (VP (VBN measured) (PP (IN by) (NP (ADJP (FW in) (FW vitro)) (NN kinase) (NN analysis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NN labelling)) (PP (IN with) (NP (NP (NN 32P)) (PRN (-LRB- -LRB-) (NP (NN i)) (-RRB- -RRB-))))) (ADVP (RB also)) (VP (VBD showed) (NP (NP (DT a) (ADJP (JJ four-) (TO to) (JJ fivefold)) (NN increase)) (PP (IN in) (NP (NN Y-394) (NN occupancy))) (PP (IN in) (NP (NN _PROT1_)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN use)) (PP (IN of) (NP (NP (NN glutathione) (NN S-transferase-Lck) (NN fusion) (NNS proteins)) (PP (IN in) (NP (NN precipitation) (NN analysis)))))) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (MD could) (VP (VB recognize) (NP (NP (NN _PROT2_)) (VP (RB as) (VBN expressed) (PP (IN in) (NP (DT the) (JJ baculovirus) (NN expression) (NN system))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN _PROT2_) (NP (NN _PROT_)))) (VP (VBZ represents) (NP (NP (NP (DT a) (JJ novel) (NN variant)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN receptor)) (VP (MD can) (ADVP (RB also)) (VP (VB serve) (PP (IN as) (NP (NN substrate))))))))) (. .)) (PRN (-LRB- -LRB-) (NP (NP (NN ABSTRACT)) (VP (VBN TRUNCATED) (PP (IN AT) (NP (CD 250) (NNS WORDS))))) (-RRB- -RRB-)))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN _PROT_) (NP (NN _PROT2_)))) (VP (VBZ represents) (NP (NP (NP (DT a) (JJ novel) (NN variant)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN receptor)) (VP (MD can) (ADVP (RB also)) (VP (VB serve) (PP (IN as) (NP (NN substrate))))))))) (. .)) (PRN (-LRB- -LRB-) (NP (NP (NN ABSTRACT)) (VP (VBN TRUNCATED) (PP (IN AT) (NP (CD 250) (NNS WORDS))))) (-RRB- -RRB-)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN _PROT_) (NP (NN _PROT_)))) (VP (VBZ represents) (NP (NP (NP (DT a) (JJ novel) (NN variant)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN receptor)) (VP (MD can) (ADVP (RB also)) (VP (VB serve) (PP (IN as) (NP (NN substrate))))))))) (. .)) (PRN (-LRB- -LRB-) (NP (NP (NN ABSTRACT)) (VP (VBN TRUNCATED) (PP (IN AT) (NP (CD 250) (NNS WORDS))))) (-RRB- -RRB-)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN _PROT1_) (NP (NN _PROT2_)))) (VP (VBZ represents) (NP (NP (NP (DT a) (JJ novel) (NN variant)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN receptor)) (VP (MD can) (ADVP (RB also)) (VP (VB serve) (PP (IN as) (NP (NN substrate))))))))) (. .)) (PRN (-LRB- -LRB-) (NP (NP (NN ABSTRACT)) (VP (VBN TRUNCATED) (PP (IN AT) (NP (CD 250) (NNS WORDS))))) (-RRB- -RRB-)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN _PROT1_) (NP (NN _PROT_)))) (VP (VBZ represents) (NP (NP (NP (DT a) (JJ novel) (NN variant)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN receptor)) (VP (MD can) (ADVP (RB also)) (VP (VB serve) (PP (IN as) (NP (NN substrate))))))))) (. .)) (PRN (-LRB- -LRB-) (NP (NP (NN ABSTRACT)) (VP (VBN TRUNCATED) (PP (IN AT) (NP (CD 250) (NNS WORDS))))) (-RRB- -RRB-)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN _PROT_) (NP (NN _PROT1_)))) (VP (VBZ represents) (NP (NP (NP (DT a) (JJ novel) (NN variant)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN receptor)) (VP (MD can) (ADVP (RB also)) (VP (VB serve) (PP (IN as) (NP (NN substrate))))))))) (. .)) (PRN (-LRB- -LRB-) (NP (NP (NN ABSTRACT)) (VP (VBN TRUNCATED) (PP (IN AT) (NP (CD 250) (NNS WORDS))))) (-RRB- -RRB-)))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN protein)) (VP (VBZ binds) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN zinc-finger) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (NP (DT an) (NN epitope)) (PP (IN with) (NP (DT the) (NN adenovirus) (NN _PROT_) (NN protein)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN protein)) (VP (VBZ binds) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN zinc-finger) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (NP (DT an) (NN epitope)) (PP (IN with) (NP (DT the) (NN adenovirus) (NN _PROT2_) (NN protein)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN protein)) (VP (VBZ binds) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN zinc-finger) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (NP (DT an) (NN epitope)) (PP (IN with) (NP (DT the) (NN adenovirus) (NN _PROT2_) (NN protein)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN target)) (PP (IN of) (NP (JJ viral) (NNS oncoproteins)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ contains) (NP (NP (DT an) (NN _PROT1_) (NN motif)) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (DT an) (JJ antigenic) (NN epitope)) (PP (IN with) (NP (NP (DT the) (NN C) (NN terminus)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (NN domain)) (VP (VBZ is) (VP (VBN conserved) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN differentiation) (NN factor))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (NN domain)) (VP (VBZ is) (VP (VBN conserved) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN differentiation) (NN factor))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (NN domain)) (VP (VBZ is) (VP (VBN conserved) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN differentiation) (NN factor))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (RB not) (ADVP (RB yet)) (ADJP (JJ clear))))) (, ,) (NP (NP (NP (PRP$ its) (NN structure)) (CC and) (NP (NN pattern))) (PP (IN of) (NP (NN expression)))) (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (JJ transcriptional) (NN regulation)) (PP (IN during) (NP (NP (NP (JJ neuronal) (NN differentiation)) (CC and) (NP (NN pathogenesis))) (PP (IN of) (NP (NN retinoblastoma))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ novel) (NN death) (JJ domain-containing) (NN protein)) (, ,)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (NN death) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ initiates) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT2_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ novel) (NN interacting) (NN protein)) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (NP (NP (DT a) (NN mutant)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBG possessing) (NP (NP (VBN enhanced) (NN killing) (NN activity)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (DT the) (ADJP (RB functionally) (JJ inactive)) (NNS mutants)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT a) (NN death) (NN domain)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (NN death) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT a) (NN death) (NN domain)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (NN death) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ contains) (NP (NP (DT a) (NN death) (NN domain)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (NN death) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN point) (NN mutation)) (PP (IN in) (NP (NN _PROT1_))) (, ,) (ADJP (JJ analogous) (PP (TO to) (NP (NP (DT the) (NN lpr) (NN mutation)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,)) (VP (VBZ abolishes) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN death) (NN domain)) (PP (TO to) (NP (NN death) (NN domain) (NN interaction)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN point) (NN mutation)) (PP (IN in) (NP (NN _PROT1_))) (, ,) (ADJP (JJ analogous) (PP (TO to) (NP (NP (DT the) (NN lpr) (NN mutation)) (PP (IN of) (NP (NN _PROT_)))))) (, ,)) (VP (VBZ abolishes) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN death) (NN domain)) (PP (TO to) (NP (NN death) (NN domain) (NN interaction)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN point) (NN mutation)) (PP (IN in) (NP (NN _PROT_))) (, ,) (ADJP (JJ analogous) (PP (TO to) (NP (NP (DT the) (NN lpr) (NN mutation)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,)) (VP (VBZ abolishes) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN death) (NN domain)) (PP (TO to) (NP (NN death) (NN domain) (NN interaction)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT2_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT1_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT1_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT1_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN MCF7)) (CC and) (NP (NN BJAB) (NNS cells))))) (VP (VBZ induces) (NP (NP (NN apoptosis)) (, ,) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (JJ _PROT_) (NN apoptosis))) (, ,) (VP (VBZ is) (VP (VBN blocked) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (DT the) (JJ proximal) (NN signal) (NN transduction)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (PRP It)) (VP (VBZ binds) (ADVP (RB homophilically)) (, ,) (PP (FW i.e.)))) (, ,) (S (NP (NP (NN _PROT1_)) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (CD one) (NN cell)))))) (VP (VBZ binds) (PP (TO to) (NP (NN _PROT2_))) (PP (IN on) (NP (DT an) (JJ apposing) (NN cell))))) (, ,) (CC and) (S (NP (DT the) (NN binding) (NN site)) (VP (VBZ lies) (PP (IN within) (NP (DT the) (NN immunoglobulin) (NN domain)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN article))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT a) (NN complex)) (VP (VBG containing) (NP (NP (NNS _PROT2_)) (, _PROT2_) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (PP (IN in) (NP (JJ mink) (NN lung) (-LRB- -LRB-) (NN MvLu) (-RRB- -RRB-) (NNS cells))) (, ,) (CC and) (PP (IN in) (NP (NP (NP (NN rat) (NN heart)) (, ,) (NP (NN lung)) (, ,) (CC and) (NP (NN brain))) (NNS tissues)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN article))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT a) (NN complex)) (VP (VBG containing) (NP (NP (NNS _PROT_)) (, _PROT_) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (PP (IN in) (NP (JJ mink) (NN lung) (-LRB- -LRB-) (NN MvLu) (-RRB- -RRB-) (NNS cells))) (, ,) (CC and) (PP (IN in) (NP (NP (NP (NN rat) (NN heart)) (, ,) (NP (NN lung)) (, ,) (CC and) (NP (NN brain))) (NNS tissues)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN article))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT a) (NN complex)) (VP (VBG containing) (NP (NP (NNS _PROT1_)) (, _PROT1_) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (PP (IN in) (NP (JJ mink) (NN lung) (-LRB- -LRB-) (NN MvLu) (-RRB- -RRB-) (NNS cells))) (, ,) (CC and) (PP (IN in) (NP (NP (NP (NN rat) (NN heart)) (, ,) (NP (NN lung)) (, ,) (CC and) (NP (NN brain))) (NNS tissues)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN binding) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (JJ intracellular) (NN segment)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ binds) (ADVP (RB directly)) (PP (PP (TO to) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (, ,) (CC but) (PP (RB not) (TO to) (NP (NP (NN alpha-)) (CC or) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN binding) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (JJ intracellular) (NN segment)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ binds) (ADVP (RB directly)) (PP (PP (TO to) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (CC but) (PP (RB not) (TO to) (NP (NP (NN alpha-)) (CC or) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN binding) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (JJ intracellular) (NN segment)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ binds) (ADVP (RB directly)) (PP (PP (TO to) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (CC but) (PP (RB not) (TO to) (NP (NP (NN alpha-)) (CC or) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN After) (NP (NP (NN pervanadate) (NN treatment)) (PP (IN of) (NP (NN MvLu) (NNS cells))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (JJ cellular) (NN tyrosine) (NN phosphatase)) (NN activity)) (PP (VBG including) (NP (NN _PROT1_))))))))) (, ,) (NP (NP (DT the) (NNS cadherins)) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VBP are) (ADVP (RB now)) (VP (VBN found) (PP (IN in) (NP (DT a) (JJ tyrosine-phosphorylated) (NN form)))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (NNS cadherins)) (VP (MD may) (VP (VB be) (NP (NP (DT an) (JJ endogenous) (NN substrate)) (PP (IN for) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN After) (NP (NP (NN pervanadate) (NN treatment)) (PP (IN of) (NP (NN MvLu) (NNS cells))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (JJ cellular) (NN tyrosine) (NN phosphatase)) (NN activity)) (PP (VBG including) (NP (NN _PROT1_))))))))) (, ,) (NP (NP (DT the) (NNS cadherins)) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBP are) (ADVP (RB now)) (VP (VBN found) (PP (IN in) (NP (DT a) (JJ tyrosine-phosphorylated) (NN form)))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (NNS cadherins)) (VP (MD may) (VP (VB be) (NP (NP (DT an) (JJ endogenous) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN After) (NP (NP (NN pervanadate) (NN treatment)) (PP (IN of) (NP (NN MvLu) (NNS cells))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (JJ cellular) (NN tyrosine) (NN phosphatase)) (NN activity)) (PP (VBG including) (NP (NN _PROT_))))))))) (, ,) (NP (NP (DT the) (NNS cadherins)) (VP (VBN associated) (PP (IN with) (NP (NN _PROT1_))))) (VP (VBP are) (ADVP (RB now)) (VP (VBN found) (PP (IN in) (NP (DT a) (JJ tyrosine-phosphorylated) (NN form)))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (NNS cadherins)) (VP (MD may) (VP (VB be) (NP (NP (DT an) (JJ endogenous) (NN substrate)) (PP (IN for) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB bind) (NP (NN 14-3-3) (NNS proteins))))))))) (, ,)) (VP (VBZ has) (ADVP (RB recently)) (VP (VBN been) (VP (VBN shown) (S (VP (VP (TO to) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_))))) (CC and) (VP (TO to) (VP (VB stimulate) (NP (PRP$ its) (NN phosphatase) (NN activity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN 14-3-3) (NN protein)) (, ,) (ADVP (RB however)) (, ,) (VP (VBZ has) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (DT the) (JJ _PROT1_) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Instead)) (, ,) (NP (NN 14-3-3)) (VP (MD may) (VP (VB facilitate) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)) (, ,) (S (VP (VBG participating) (PP (IN in) (NP (NP (DT the) (NN linkage)) (PP (IN between) (NP (NP (JJ mitogenic) (NN signaling)) (CC and) (NP (DT the) (NN cell) (NN cycle) (NN machinery))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN bZIP) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBP mediate) (NP (NP (DT a) (JJ physical) (NN association)) (PP (IN with) (NP (DT the) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN bZIP) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBP mediate) (NP (NP (DT a) (JJ physical) (NN association)) (PP (IN with) (NP (DT the) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN bZIP) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBP mediate) (NP (NP (DT a) (JJ physical) (NN association)) (PP (IN with) (NP (DT the) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS oncoproteins)) (VP (VBP form) (NP (NP (DT a) (NN complex)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (NP (NN transcription)) (PP (IN from) (NP (NP (NNS promoters)) (VP (VBG containing) (NP (NN AP-1) (NN binding) (NNS sites)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proteins))) (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NP (DT the) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ general) (NN transcription) (NN factor)) (VP (VBN required) (PP (IN for) (S (VP (VBG initiating) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NN transcription) (NNS complexes))))))))) (, ,)))))) (VP (VBD was) (VP (VBN investigated)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS proteins))) (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NP (DT the) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ general) (NN transcription) (NN factor)) (VP (VBN required) (PP (IN for) (S (VP (VBG initiating) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NN transcription) (NNS complexes))))))))) (, ,)))))) (VP (VBD was) (VP (VBN investigated)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS proteins))) (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NP (DT the) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ general) (NN transcription) (NN factor)) (VP (VBN required) (PP (IN for) (S (VP (VBG initiating) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NN transcription) (NNS complexes))))))))) (, ,)))))) (VP (VBD was) (VP (VBN investigated)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS proteins))) (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NP (DT the) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ general) (NN transcription) (NN factor)) (VP (VBN required) (PP (IN for) (S (VP (VBG initiating) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NN transcription) (NNS complexes))))))))) (, ,)))))) (VP (VBD was) (VP (VBN investigated)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS proteins))) (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NP (DT the) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ general) (NN transcription) (NN factor)) (VP (VBN required) (PP (IN for) (S (VP (VBG initiating) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NN transcription) (NNS complexes))))))))) (, ,)))))) (VP (VBD was) (VP (VBN investigated)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS proteins))) (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NP (DT the) (ADJP (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ general) (NN transcription) (NN factor)) (VP (VBN required) (PP (IN for) (S (VP (VBG initiating) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NN transcription) (NNS complexes))))))))) (, ,)))))) (VP (VBD was) (VP (VBN investigated)))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT2_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT2_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT1_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT1_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT1_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (NN co-immunoprecipitation)) (CC and) (NP (JJ protein-protein) (NN association) (NNS assays))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (ADVP (ADVP (RB specifically)) (CC and) (ADVP (RB stably))) (PP (TO to) (NP (JJ _PROT_) (NN analysis))) (S (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (CC both) (DT the) (NP (NP (JJ basic) (NN region)) (CC and) (NP (NN leucine) (NN zipper))) (NNS domains)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (JJ stable) (NN association)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ 51-residue) (NN region)) (PP (IN from) (NP (NP (DT the) (VBN conserved) (JJ C-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (JJ viral) (NN activator) (NN protein) (NN _PROT2_)))))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS proteins))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ 51-residue) (NN region)) (PP (IN from) (NP (NP (DT the) (VBN conserved) (JJ C-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (JJ viral) (NN activator) (NN protein) (NN _PROT_)))))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS proteins))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ 51-residue) (NN region)) (PP (IN from) (NP (NP (DT the) (VBN conserved) (JJ C-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (JJ viral) (NN activator) (NN protein) (NN _PROT_)))))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS proteins))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ 51-residue) (NN region)) (PP (IN from) (NP (NP (DT the) (VBN conserved) (JJ C-terminal) (NN region)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (JJ viral) (NN activator) (NN protein) (NN _PROT1_)))))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS proteins))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ 51-residue) (NN region)) (PP (IN from) (NP (NP (DT the) (VBN conserved) (JJ C-terminal) (NN region)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (JJ viral) (NN activator) (NN protein) (NN _PROT1_)))))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS proteins))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ 51-residue) (NN region)) (PP (IN from) (NP (NP (DT the) (VBN conserved) (JJ C-terminal) (NN region)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (JJ viral) (NN activator) (NN protein) (NN _PROT_)))))))) (, ,)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proteins))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proteins)) (VP (VBP function) (PP (IN as) (NP (NP (JJ transcriptional) (NNS activators)) (, ,) (PP (IN in) (NP (NN part))))) (PP (IN by) (S (VP (VBG recruiting) (NP (NN _PROT_)) (S (VP (TO to) (VP (VB form) (NP (NNS complexes)) (S (VP (TO to) (VP (VB initiate) (NP (NN RNA) (NN synthesis)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS proteins)) (VP (VBP function) (PP (IN as) (NP (NP (JJ transcriptional) (NNS activators)) (, ,) (PP (IN in) (NP (NN part))))) (PP (IN by) (S (VP (VBG recruiting) (NP (NN _PROT2_)) (S (VP (TO to) (VP (VB form) (NP (NNS complexes)) (S (VP (TO to) (VP (VB initiate) (NP (NN RNA) (NN synthesis)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS proteins)) (VP (VBP function) (PP (IN as) (NP (NP (JJ transcriptional) (NNS activators)) (, ,) (PP (IN in) (NP (NN part))))) (PP (IN by) (S (VP (VBG recruiting) (NP (NN _PROT2_)) (S (VP (TO to) (VP (VB form) (NP (NNS complexes)) (S (VP (TO to) (VP (VB initiate) (NP (NN RNA) (NN synthesis)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation)) (PP (IN of) (NP (JJ unactivated) (JJ avian) (NN progesterone) (NN receptor)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN copurification)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (CD three) (JJ additional) (NNS proteins)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (JJ immunoaffinity-purified) (NN _PROT2_) (NNS complexes)))) (PP (IN along) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT another) (NN protein)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (JJ immunoaffinity-purified) (NN _PROT_) (NNS complexes)))) (PP (IN along) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT another) (NN protein)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (JJ immunoaffinity-purified) (NN _PROT_) (NNS complexes)))) (PP (IN along) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT another) (NN protein)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (JJ immunoaffinity-purified) (NN _PROT1_) (NNS complexes)))) (PP (IN along) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT another) (NN protein)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (JJ immunoaffinity-purified) (NN _PROT1_) (NNS complexes)))) (PP (IN along) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT another) (NN protein)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (JJ immunoaffinity-purified) (NN _PROT_) (NNS complexes)))) (PP (IN along) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT another) (NN protein)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBP detect) (NP (NP (JJ similar) (NNS levels)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT all) (NNS tissues)) (VP (VBN tested)))))) (CC and) (VP (VB cross-react) (PP (IN with) (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN size)) (PP (IN in) (NP (NP (NNS mice)) (, ,) (NP (NNS rabbits)) (, ,) (NP (NN guinea) (NNS pigs)) (, ,) (NP (NNS humans)) (, ,) (CC and) (NP (FW Saccharomyces) (FW cerevisiae))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (VBN conserved) (NN protein)) (PP (IN of) (NP (JJ broad) (NN tissue) (NN distribution))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBP detect) (NP (NP (JJ similar) (NNS levels)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT all) (NNS tissues)) (VP (VBN tested)))))) (CC and) (VP (VB cross-react) (PP (IN with) (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN size)) (PP (IN in) (NP (NP (NNS mice)) (, ,) (NP (NNS rabbits)) (, ,) (NP (NN guinea) (NNS pigs)) (, ,) (NP (NNS humans)) (, ,) (CC and) (NP (FW Saccharomyces) (FW cerevisiae))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (VBN conserved) (NN protein)) (PP (IN of) (NP (JJ broad) (NN tissue) (NN distribution))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Antibodies)) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBP detect) (NP (NP (JJ similar) (NNS levels)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT all) (NNS tissues)) (VP (VBN tested)))))) (CC and) (VP (VB cross-react) (PP (IN with) (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN size)) (PP (IN in) (NP (NP (NNS mice)) (, ,) (NP (NNS rabbits)) (, ,) (NP (NN guinea) (NNS pigs)) (, ,) (NP (NNS humans)) (, ,) (CC and) (NP (FW Saccharomyces) (FW cerevisiae))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (VBN conserved) (NN protein)) (PP (IN of) (NP (JJ broad) (NN tissue) (NN distribution))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Bacterially) (VBN overexpressed)) (JJ human) (NN _PROT1_)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB raise) (NP (NP (JJ several) (JJ monoclonal) (NNS antibodies)) (PP (TO to) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS antibodies)) (ADVP (RB specifically)) (VP (VP (NN immunoprecipitate) (NP (NP (NN _PROT1_)) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NN _PROT2_)))))) (PP (IN in) (NP (NP (DT all) (NNS tissues)) (VP (VBN tested))))) (CC and) (VP (MD can) (VP (VB be) (VP (VBN used) (S (VP (TO to) (S (NP (NN immunoaffinity)) (VP (VB isolate) (NP (NN progesterone) (NN receptor) (NNS complexes)) (PP (IN from) (NP (NN chicken) (NN oviduct) (NN cytosol)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NN participation)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN chain))) (PP (IN in) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NN participation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN chain))) (PP (IN in) (NP (NN _PROT2_) (NN _PROT_) (NNS complexes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NN participation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN chain))) (PP (IN in) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NN participation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN chain))) (PP (IN in) (NP (NN _PROT2_) (NN _PROT_) (NNS complexes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NN participation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN chain))) (PP (IN in) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NN participation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN chain))) (PP (IN in) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NNS complexes))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT2_) (NN _PROT_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT2_) (NN _PROT_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT2_) (NN _PROT_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN gamma) (NN chain)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VP (VBZ is) (VP (VBN shared) (PP (IN with) (NP (DT the) (JJ functional) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ is) (ADVP (RB causatively)) (ADJP (JJ related) (PP (TO to) (NP (NP (NP (JJ X-linked) (JJ severe) (JJ combined) (NN immunodeficiency)) (PRN (-LRB- -LRB-) (NP (NN XSCID)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN ascribed) (PP (TO to) (NP (DT a) (JJ profound) (NN T) (NN cell) (NN defect))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN with) (NP (NP (JJ monoclonal) (NNS antibodies)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN _PROT1_) (NN receptor) (NN gamma) (NN chain))))))) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (NN gamma) (NN chain)) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (JJ functional) (JJ high-affinity) (NN receptor) (NNS complexes)) (PP (IN for) (NP (NP (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN differentiation)) (PP (IN of) (NP (NP (NP (NN T)) (CC and) (NP (NN B))) (NNS cells)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Tumor) (NN necrosis) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN TNF)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (VBN secreted)) (CC and) (NP (NN cell) (NN surface) (NNS cytokines)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP participate) (PP (IN in) (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (ADJP (ADJP (JJ immune)) (CC and) (ADJP (JJ inflammatory))) (NNS responses))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN cell) (NN surface) (NN form)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN assembled) (PP (IN during) (NP (NN biosynthesis))) (PP (IN as) (NP (NP (DT a) (JJ heteromeric) (NN complex)) (PP (IN with) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN type) (CD II) (NN transmembrane) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (NP (NP (DT another) (NN member)) (PP (IN of) (NP (DT the) (NN TNF) (NN ligand) (NN family))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN cell) (NN surface) (NN form)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN assembled) (PP (IN during) (NP (NN biosynthesis))) (PP (IN as) (NP (NP (DT a) (JJ heteromeric) (NN complex)) (PP (IN with) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN type) (CD II) (NN transmembrane) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (NP (NP (DT another) (NN member)) (PP (IN of) (NP (DT the) (NN TNF) (NN ligand) (NN family))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cell) (NN surface) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN assembled) (PP (IN during) (NP (NN biosynthesis))) (PP (IN as) (NP (NP (DT a) (JJ heteromeric) (NN complex)) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN type) (CD II) (NN transmembrane) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (NP (NP (DT another) (NN member)) (PP (IN of) (NP (DT the) (NN TNF) (NN ligand) (NN family))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Secreted) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN homotrimer)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (PP (TO to) (NP (NP (JJ distinct) (NN TNF) (NNS receptors)) (PP (IN of) (NP (QP (CD 60) (CC and) (CD 80)) (NNS kilodaltons))))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (DT these) (NNS receptors)) (VP (VBP do) (RB not) (VP (VB recognize) (NP (DT the) (JJ major) (NN cell) (NN surface) (NN _PROT2_) (NN complex))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Secreted) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN homotrimer)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (PP (TO to) (NP (NP (JJ distinct) (NN TNF) (NNS receptors)) (PP (IN of) (NP (QP (CD 60) (CC and) (CD 80)) (NNS kilodaltons))))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (DT these) (NNS receptors)) (VP (VBP do) (RB not) (VP (VB recognize) (NP (DT the) (JJ major) (NN cell) (NN surface) (NN _PROT2_) (NN complex))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Secreted) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN homotrimer)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (PP (TO to) (NP (NP (JJ distinct) (NN TNF) (NNS receptors)) (PP (IN of) (NP (QP (CD 60) (CC and) (CD 80)) (NNS kilodaltons))))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (DT these) (NNS receptors)) (VP (VBP do) (RB not) (VP (VB recognize) (NP (DT the) (JJ major) (NN cell) (NN surface) (NN _PROT1_AND_PROT2_) (NN complex))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN receptor)) (ADJP (JJ specific) (PP (IN for) (NP (JJ human) (NN _PROT1_))))) (VP (VBD was) (VP (VBN identified) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN cell) (NN surface) (NN LT)) (VP (MD may) (VP (VBP have) (NP (NP (NNS functions)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (PP (IN of) (NP (JJ secreted) (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (DT a) (JJ novel) (JJ high) (NN affinity) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN Expression)) (PP (IN on) (NP (NN T) (NNS cells)))) (CC and) (NP (NP (NN association)) (PP (IN with) (NP (ADJP (NN _PROT_) (VBN driven)) (NN proliferation)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (DT a) (JJ novel) (JJ high) (NN affinity) (JJ human) (NN _PROT1_) (NN _PROT_) (NN Expression)) (PP (IN on) (NP (NN T) (NNS cells)))) (CC and) (NP (NP (NN association)) (PP (IN with) (NP (ADJP (NN _PROT2_) (VBN driven)) (NN proliferation)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NP (DT a) (JJ novel) (JJ high) (NN affinity) (JJ human) (NN _PROT1_) (NN _PROT1_) (NN Expression)) (PP (IN on) (NP (NN T) (NNS cells)))) (CC and) (NP (NP (NN association)) (PP (IN with) (NP (ADJP (NN _PROT2_) (VBN driven)) (NN proliferation)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBP have) (ADVP (RB previously)) (VP (VBN demonstrated) (NP (JJ such) (NNS changes)) (PP (IN by) (NP (NN affinity) (NN cross-linking) (NNS studies))))) (, ,) (CC and) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (S (NP (JJ unstimulated) (JJ human) (NN T) (NNS cells)) (VP (VBP express) (NP (NP (DT a) (JJ single) (NN _PROT1_)) (PP (IN of) (NP (CD 90) (NN kDa)))))) (, ,) (IN whereas) (S (NP (VBN activated) (NN T) (NNS cells)) (VP (VBP express) (NP (DT an) (JJ additional) (JJ 76-kDa) (NN _PROT2_) (NN binding) (NN protein)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (NP (NP (DT the) (NP (NP (NN origin)) (CC and) (NP (NN function)))) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS molecules)))) (VP (VBP have) (VP (VBN been) (VP (VBN investigated))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NP (DT each)) (PP (IN of) (NP (DT these) (NNS receptors))))) (PP (IN in) (NP (ADJP (NN _PROT1_) (VBN driven)) (NN proliferation))))))) (, ,) (NP (NP (NN _PROT2_) (NN expression)) (CC and) (NP (NN proliferative) (NN capacity))) (VP (VBD were) (VP (VBN monitored) (PP (IN during) (NP (JJ mitogenic) (NN stimulation)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT1_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT1_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT2_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT1_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT1_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT2_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT1_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT1_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PBMC))) (S (VP (TO to) (VP (VB proliferate) (PP (TO to) (NP (NN _PROT_))))))) (VP (VBD correlated) (PP (PP (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (, ,) (CC and) (PP (RB not) (IN with) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT1_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT2_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT1_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT2_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT1_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT2_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT1_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT2_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT1_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT2_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT1_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT1_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT2_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT1_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT2_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT1_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT2_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT1_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT2_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT1_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT1_) (NN _PROT2_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT1_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT2_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT1_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT2_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT1_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT1_))) (, ,) (NP (DT the) (NN _PROT2_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT1_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT2_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT1_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT1_) (NN _PROT2_)) (VP (VBD bound) (NP (NP (NN _PROT_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT1_) (NN _PROT_)) (VP (VBD bound) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ _PROT_) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN via) (NP (JJ high) (NN affinity) (NN _PROT_)))))) (, ,) (CC and) (S (ADVP (RB accordingly)) (, ,) (NP (NN Scatchard) (NN analysis)) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN _PROT_))) (, ,) (NP (DT the) (NN _PROT_) (NN _PROT1_)) (VP (VBD bound) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (JJ dual) (PRN (-LRB- -LRB-) (NP (JJ high) (: ;) (NP (NP (NN Kd)) (ADJP (ADJP (CD 38) (NN pM)) (CC and) (ADJP (JJ low)))) (: ;) (NP (NN Kd) (CD 360) (NN pM))) (-RRB- -RRB-)) (NN affinity)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deglycosylation) (NNS studies)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (VP (VBP are) (RB not) (ADVP (RB simply)) (VP (ADVP (RB differently)) (VBN glycosylated) (NP (NP (NNS isoforms)) (PP (IN of) (NP (DT a) (JJ single) (NN receptor)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deglycosylation) (NNS studies)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT2_))) (VP (VBP are) (RB not) (ADVP (RB simply)) (VP (ADVP (RB differently)) (VBN glycosylated) (NP (NP (NNS isoforms)) (PP (IN of) (NP (DT a) (JJ single) (NN receptor)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deglycosylation) (NNS studies)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT2_))) (VP (VBP are) (RB not) (ADVP (RB simply)) (VP (ADVP (RB differently)) (VBN glycosylated) (NP (NP (NNS isoforms)) (PP (IN of) (NP (DT a) (JJ single) (NN receptor)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT1_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT2_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT1_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT_) (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT1_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT1_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT1_) (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT1_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT1_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN agreement))) (, ,) (NP (NP (NN mAb)) (PP (TO to) (NP (DT the) (ADJP (RB previously) (VBN cloned)) (NN _PROT_)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB stain) (NP (NP (JJ unstimulated) (NN T) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (NP (RB only) (DT the) (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NP (NN T-cell) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (RB predominantly) (DT the) (NN _PROT1_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS antibodies)) (ADVP (RB also)) (VP (VP (VBD immunoprecipitated) (NP (DT the) (VBN cloned) (NN _PROT1_)) (PP (IN as) (NP (NP (DT a) (JJ 90-kDa) (NNS species)) (PP (IN from) (NP (DT both) (JJ 125-I-surface-labeled) (ADJP (ADJP (VBG resting)) (CC and) (ADJP (VBN activated))) (NN T) (NNS cells)))))) (, ,) (CC but) (VP (VBD were) (ADJP (JJ unable) (S (VP (TO to) (VP (VB precipitate) (NP (DT the) (JJ 76-kDa) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT1_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT1_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT1_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT1_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT1_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT1_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT1_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN PCR) (NN analysis)) (PP (IN of) (NP (JJ _PROT_) (NNS cells)))) (VP (MD could) (RB not) (VP (VB detect) (NP (NP (NN splicing)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG excluding) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB previously) (JJ undescribed)) (NN splice) (NN variant)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT2_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT2_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT2_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT1_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT1_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT1_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT2_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT2_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN T-cell) (NN homologue)) (PP (IN of) (NP (DT the) (VBN cloned) (NN _PROT_)))))))) (, ,) (CC and) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT2_))) (VP (VBP have) (NP (JJ different) (JJ extracellular) (NNS domains)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (JJ 76-kDa) (NN receptor)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (JJ high) (NN affinity) (NN _PROT1_)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (VP (VB be) (ADJP (JJ necessary) (PP (IN for) (NP (NP (ADJP (NN _PROT2_) (VBN driven)) (NN proliferation)) (PP (IN in) (NP (JJ human) (NN T) (NNS cells)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT2_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT2_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (VP (MD _PROT2_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT1_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT1_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Similarly)) (, ,) (PP (IN in) (NP (JJ mammalian) (NNS cells))) (NP (NP (NP (DT the) (JJ cyclic) (NN adenosine) (CD 3)) ('' ')) (, ,) (NP (NP (JJ 5'-monophosphate-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (VP (MD _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-)))) (VP (VBP are) (VP (VBN complexed) (PP (IN by) (NP (DT an) (NP (NP (DT _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT_)))) (CC or) (VP (MD _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT_)))) (CC or) (VP (MD _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT2_)))) (CC or) (VP (MD _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT_)))) (CC or) (VP (MD _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT_)))) (CC or) (VP (MD _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT2_)))) (CC or) (VP (MD _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT_)))) (CC or) (VP (MD _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT1_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT2_)))) (CC or) (VP (MD _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT1_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT_)))) (CC or) (VP (MD _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion) (NN analysis)) (CC and) (NP (NN binding) (NNS studies))) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT a) (JJ third) (NN enzyme)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN at) (NP (NP (DT a) (NN site)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT those)) (VP (VP (VBN bound) (PP (IN by) (NP (NN _PROT1_)))) (CC or) (VP (MD _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ subcellular) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (ADJP (JJ similar)) (PP (IN in) (NP (NNS neurons))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (ADJP (JJ crucial) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (CC both) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN R)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_))))))))))) (VP (VBD were) (VP (VBN identified) (PP (IN by) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NN alanine) (NN scanning) (NNS mutants)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NNS assays)) (PP (IN for) (NP (CC both) (NP (NN receptor) (NN binding)) (CC and) (NP (NN bioactivity))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN region)) (PP (IN of) (NP (NN _PROT1_))) (ADJP (RBS most) (JJ important) (PP (IN for) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN _PROT2_))))))) (VP (VBZ is) (VP (VBN composed) (PP (IN of) (NP (NP (NNS residues)) (PP (IN from) (NP (NP (NP (DT the) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN D-helix)))) (, ,) (NP (NP (NN carboxyl) (NN terminus)) (PP (IN of) (NP (DT the) (NN B-helix)))) (, ,) (CC and) (NP (NN C-D) (NN loop))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (CD two) (NNS residues)) (PP (IN of) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBP contribute) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ free) (NN energy)) (PP (IN for) (NP (NP (NN _PROT2_) (NN binding)) (, ,) (NP (NP (CD Phe-156)) (CC and) (NP (CD Lys-159)))))))))))) (VP (VBP are) (VP (VBN surrounded) (PP (IN by) (NP (NP (JJ other) (NNS residues)) (SBAR (WHNP (WDT which)) (S (VP (VBP have) (NP (RB only) (DT a) (JJ moderate) (NN impact)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ second) (NN region)) (PP (IN of) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (NNS residues)) (PP (IN from) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (DT the) (NN D-helix) (CC and) (NN A-B) (NN loop)))))))))) (ADVP (RB also)) (VP (VBD had) (NP (DT a) (JJ weak) (NN influence)) (PP (IN on) (NP (NN _PROT2_) (NN binding))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Residues)) (PP (IN in) (NP (NP (NN _PROT1_)) (PP (IN from) (NP (CC both) (DT the) (NP (NN A-)) (CC and) (NP (NN C-helices))))))) (VP (VBP are) (VP (VBN involved) (PP (IN in) (S (VP (VBG binding) (NP (DT the) (NN _PROT2_) (NN co-receptor)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Abolition)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN binding) (NN site)) (PP (IN in) (NP (NN _PROT2_)))))) (VP (VBD created) (NP (NP (NNS antagonists)) (PP (IN of) (NP (NN _PROT_) (NN action)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Abolition)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN binding) (NN site)) (PP (IN in) (NP (NN _PROT_)))))) (VP (VBD created) (NP (NP (NNS antagonists)) (PP (IN of) (NP (NN _PROT2_) (NN action)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Abolition)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN binding) (NN site)) (PP (IN in) (NP (NN _PROT1_)))))) (VP (VBD created) (NP (NP (NNS antagonists)) (PP (IN of) (NP (NN _PROT2_) (NN action)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS kinetics)) (PP (IN of) (NP (NP (JJ amyloid) (NN fibril) (NN formation)) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBP are) (ADJP (JJ typical) (PP (IN of) (NP (DT a) (JJ nucleation-dependent) (NN polymerization) (NN mechanism)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Fusion) (NNS proteins)) (VP (VBD were) (VP (VBN created) (PP (IN by) (S (VP (VBG linking) (NP (DT the) (NN _PROT1_) (NN fragment)) (PP (PP (TO to) (NP (DT a) (NP (NP (NN _PROT2_) (JJ DNA-binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN bait)) (-RRB- -RRB-))))) (CC and) (PP (ADVP (RB also)) (TO to) (NP (NP (DT a) (NN _PROT_) (NN transactivation) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN prey)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Fusion) (NNS proteins)) (VP (VBD were) (VP (VBN created) (PP (IN by) (S (VP (VBG linking) (NP (DT the) (NN _PROT1_) (NN fragment)) (PP (PP (TO to) (NP (DT a) (NP (NP (NN _PROT_) (JJ DNA-binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN bait)) (-RRB- -RRB-))))) (CC and) (PP (ADVP (RB also)) (TO to) (NP (NP (DT a) (NN _PROT2_) (NN transactivation) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN prey)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Fusion) (NNS proteins)) (VP (VBD were) (VP (VBN created) (PP (IN by) (S (VP (VBG linking) (NP (DT the) (NN _PROT_) (NN fragment)) (PP (PP (TO to) (NP (DT a) (NP (NP (NN _PROT1_) (JJ DNA-binding) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN bait)) (-RRB- -RRB-))))) (CC and) (PP (ADVP (RB also)) (TO to) (NP (NP (DT a) (NN _PROT2_) (NN transactivation) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN prey)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Protein-protein) (NNS interactions)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (NP (NN expression)) (PP (IN of) (NP (DT these) (NN fusion) (NNS proteins))) (PP (IN in) (NP (NP (FW Saccharomyces) (FW cerevisiae)) (VP (VBG harboring) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (NP (NNS genes))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (JJ LexA-dependent) (NNS operators))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Protein-protein) (NNS interactions)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (NP (NN expression)) (PP (IN of) (NP (DT these) (NN fusion) (NNS proteins))) (PP (IN in) (NP (NP (FW Saccharomyces) (FW cerevisiae)) (VP (VBG harboring) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (NP (NNS genes))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (JJ LexA-dependent) (NNS operators))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Protein-protein) (NNS interactions)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (NP (NN expression)) (PP (IN of) (NP (DT these) (NN fusion) (NNS proteins))) (PP (IN in) (NP (NP (FW Saccharomyces) (FW cerevisiae)) (VP (VBG harboring) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (NP (NNS genes))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (JJ LexA-dependent) (NNS operators))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Protein-protein) (NNS interactions)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (NP (NN expression)) (PP (IN of) (NP (DT these) (NN fusion) (NNS proteins))) (PP (IN in) (NP (NP (FW Saccharomyces) (FW cerevisiae)) (VP (VBG harboring) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (NP (NNS genes))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (JJ LexA-dependent) (NNS operators))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Protein-protein) (NNS interactions)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (NP (NN expression)) (PP (IN of) (NP (DT these) (NN fusion) (NNS proteins))) (PP (IN in) (NP (NP (FW Saccharomyces) (FW cerevisiae)) (VP (VBG harboring) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (NP (NNS genes))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (JJ LexA-dependent) (NNS operators))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Protein-protein) (NNS interactions)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (NP (NN expression)) (PP (IN of) (NP (DT these) (NN fusion) (NNS proteins))) (PP (IN in) (NP (NP (FW Saccharomyces) (FW cerevisiae)) (VP (VBG harboring) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (NP (NNS genes))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (JJ LexA-dependent) (NNS operators))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT2_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT1_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT1_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN protein)) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN Drosophila) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD failed) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN fragment)) (VP (VBN fused) (PP (TO to) (NP (NN _PROT_))))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT the) (VBN observed) (NN _PROT1_AND_PROT2_) (NN interaction)) (VP (VBD was) (ADJP (JJ specific))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Specificity)) (VP (VBD was) (ADVP (RB further)) (VP (VBN shown) (PP (IN by) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (DT no) (JJ significant) (NN interaction)) (VP (VBD was) (VP (VBN observed) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG expressing) (NP (NN _PROT1_AND_PROT2_) (NN bait)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NN _PROT_) (NN transactivation) (NN domain)) (VP (VBD was) (VP (VBN fused) (PP (TO to) (NP (NP (DT an) (NN _PROT_) (NN fragment)) (PP (IN with) (NP (NN Phe-Phe))))) (PP (IN at) (NP (NP (NNS residues) (CD 19) (CC and) (CD 20)) (VP (VBN replaced) (PP (IN by) (NP (NP (NP (NN Thr-Thr)) (PRN (-LRB- -LRB-) (NP (NN AbetaTT)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN finding)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ consistent) (PP (IN with) (NP (NP (ADJP (FW in) (FW vitro)) (NNS observations)) (VP (VBN made) (PP (IN by) (NP (NNS others)))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Specificity)) (VP (VBD was) (ADVP (RB further)) (VP (VBN shown) (PP (IN by) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (DT no) (JJ significant) (NN interaction)) (VP (VBD was) (VP (VBN observed) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG expressing) (NP (NN _PROT1_) (NN bait)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NN _PROT2_) (NN transactivation) (NN domain)) (VP (VBD was) (VP (VBN fused) (PP (TO to) (NP (NP (DT an) (NN _PROT_) (NN fragment)) (PP (IN with) (NP (NN Phe-Phe))))) (PP (IN at) (NP (NP (NNS residues) (CD 19) (CC and) (CD 20)) (VP (VBN replaced) (PP (IN by) (NP (NP (NP (NN Thr-Thr)) (PRN (-LRB- -LRB-) (NP (NN AbetaTT)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN finding)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ consistent) (PP (IN with) (NP (NP (ADJP (FW in) (FW vitro)) (NNS observations)) (VP (VBN made) (PP (IN by) (NP (NNS others)))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Specificity)) (VP (VBD was) (ADVP (RB further)) (VP (VBN shown) (PP (IN by) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (DT no) (JJ significant) (NN interaction)) (VP (VBD was) (VP (VBN observed) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG expressing) (NP (NN _PROT1_) (NN bait)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NN _PROT_) (NN transactivation) (NN domain)) (VP (VBD was) (VP (VBN fused) (PP (TO to) (NP (NP (DT an) (NN _PROT2_) (NN fragment)) (PP (IN with) (NP (NN Phe-Phe))))) (PP (IN at) (NP (NP (NNS residues) (CD 19) (CC and) (CD 20)) (VP (VBN replaced) (PP (IN by) (NP (NP (NP (NN Thr-Thr)) (PRN (-LRB- -LRB-) (NP (NN AbetaTT)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN finding)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ consistent) (PP (IN with) (NP (NP (ADJP (FW in) (FW vitro)) (NNS observations)) (VP (VBN made) (PP (IN by) (NP (NNS others)))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Specificity)) (VP (VBD was) (ADVP (RB further)) (VP (VBN shown) (PP (IN by) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (DT no) (JJ significant) (NN interaction)) (VP (VBD was) (VP (VBN observed) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG expressing) (NP (NN _PROT1_) (NN bait)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NN _PROT2_) (NN transactivation) (NN domain)) (VP (VBD was) (VP (VBN fused) (PP (TO to) (NP (NP (DT an) (NN _PROT_) (NN fragment)) (PP (IN with) (NP (NN Phe-Phe))))) (PP (IN at) (NP (NP (NNS residues) (CD 19) (CC and) (CD 20)) (VP (VBN replaced) (PP (IN by) (NP (NP (NP (NN Thr-Thr)) (PRN (-LRB- -LRB-) (NP (NN AbetaTT)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN finding)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ consistent) (PP (IN with) (NP (NP (ADJP (FW in) (FW vitro)) (NNS observations)) (VP (VBN made) (PP (IN by) (NP (NNS others)))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Specificity)) (VP (VBD was) (ADVP (RB further)) (VP (VBN shown) (PP (IN by) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (DT no) (JJ significant) (NN interaction)) (VP (VBD was) (VP (VBN observed) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG expressing) (NP (NN _PROT1_) (NN bait)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NN _PROT_) (NN transactivation) (NN domain)) (VP (VBD was) (VP (VBN fused) (PP (TO to) (NP (NP (DT an) (NN _PROT2_) (NN fragment)) (PP (IN with) (NP (NN Phe-Phe))))) (PP (IN at) (NP (NP (NNS residues) (CD 19) (CC and) (CD 20)) (VP (VBN replaced) (PP (IN by) (NP (NP (NP (NN Thr-Thr)) (PRN (-LRB- -LRB-) (NP (NN AbetaTT)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN finding)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ consistent) (PP (IN with) (NP (NP (ADJP (FW in) (FW vitro)) (NNS observations)) (VP (VBN made) (PP (IN by) (NP (NNS others)))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Specificity)) (VP (VBD was) (ADVP (RB further)) (VP (VBN shown) (PP (IN by) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (DT no) (JJ significant) (NN interaction)) (VP (VBD was) (VP (VBN observed) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG expressing) (NP (NN _PROT_) (NN bait)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NN _PROT1_) (NN transactivation) (NN domain)) (VP (VBD was) (VP (VBN fused) (PP (TO to) (NP (NP (DT an) (NN _PROT2_) (NN fragment)) (PP (IN with) (NP (NN Phe-Phe))))) (PP (IN at) (NP (NP (NNS residues) (CD 19) (CC and) (CD 20)) (VP (VBN replaced) (PP (IN by) (NP (NP (NP (NN Thr-Thr)) (PRN (-LRB- -LRB-) (NP (NN AbetaTT)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN finding)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ consistent) (PP (IN with) (NP (NP (ADJP (FW in) (FW vitro)) (NNS observations)) (VP (VBN made) (PP (IN by) (NP (NNS others)))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN dimerization))) (PP (IN on) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ high) (NN affinity) (JJ hexameric) (NN _PROT_) (NN complex))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN dimerization))) (PP (IN on) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ high) (NN affinity) (JJ hexameric) (NN _PROT2_) (NN complex))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN dimerization))) (PP (IN on) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ high) (NN affinity) (JJ hexameric) (NN _PROT2_) (NN complex))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN dimerization))) (PP (IN on) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ high) (NN affinity) (JJ hexameric) (NN _PROT2_) (NN complex))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN dimerization))) (PP (IN on) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ high) (NN affinity) (JJ hexameric) (NN _PROT2_) (NN complex))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN dimerization))) (PP (IN on) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ high) (NN affinity) (JJ hexameric) (NN _PROT1_AND_PROT2_) (NN complex))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT2_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT2_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT2_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT1_) (NN _PROT_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (JJ high) (NN affinity) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN signaling) (NN complex)) (VP (VBZ consists) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (JJ membrane-associated) (NN receptor) (NNS components)) (: :) (NP (NP (DT a) (JJ low) (NN affinity)) (CC but) (NP (NP (NP (JJ specific) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (DT the) (NN affinity))) (JJ converter/signal) (NN transducing) (NN protein) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT2_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT1_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT2_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (ADJP (ADJP (ADJP (JJ Monomeric)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_)) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ dimeric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS forms)) (PP (IN of) (NP (FW Escherichia) (JJ coli-derived) (JJ human) (NN _PROT_)))) (CC and) (NP (NP (DT the) (ADJP (ADJP (JJ extracellular)) (PRN (-LRB- -LRB-) (NP (`` ``) (JJ soluble) (NNS '')) (-RRB- -RRB-))) (NNS portions)) (PP (IN of) (NP (DT the) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_))))))) (VP (VBP have) (VP (VBN been) (VP (VBN purified) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_) (NN dimerization))) (PP (IN on) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN receptor) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NP (DT a) (JJR higher) (NN binding) (NN affinity)) (PP (IN for) (NP (JJ immobilized) (NN _PROT2_)))) (, ,) (SBAR (IN as) (S (VP (VBN determined) (PP (IN by) (NP (NP (JJ biosensor) (NN analysis)) (VP (VBG employing) (NP (NP (NN surface) (NN plasmon) (NN resonance)) (NN detection))))))))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (CD _PROT_))) (PP (IN in) (NP (DT a) (NN STAT3) (NN phosphorylation) (NN assay)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NP (DT a) (JJR higher) (NN binding) (NN affinity)) (PP (IN for) (NP (JJ immobilized) (NN _PROT_)))) (, ,) (SBAR (IN as) (S (VP (VBN determined) (PP (IN by) (NP (NP (JJ biosensor) (NN analysis)) (VP (VBG employing) (NP (NP (NN surface) (NN plasmon) (NN resonance)) (NN detection))))))))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (CD _PROT_))) (PP (IN in) (NP (DT a) (NN STAT3) (NN phosphorylation) (NN assay)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NP (DT a) (JJR higher) (NN binding) (NN affinity)) (PP (IN for) (NP (JJ immobilized) (NN _PROT_)))) (, ,) (SBAR (IN as) (S (VP (VBN determined) (PP (IN by) (NP (NP (JJ biosensor) (NN analysis)) (VP (VBG employing) (NP (NP (NN surface) (NN plasmon) (NN resonance)) (NN detection))))))))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (CD _PROT2_))) (PP (IN in) (NP (DT a) (NN STAT3) (NN phosphorylation) (NN assay)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJR higher) (NN binding) (NN affinity)) (PP (IN for) (NP (JJ immobilized) (NN _PROT1_)))) (, ,) (SBAR (IN as) (S (VP (VBN determined) (PP (IN by) (NP (NP (JJ biosensor) (NN analysis)) (VP (VBG employing) (NP (NP (NN surface) (NN plasmon) (NN resonance)) (NN detection))))))))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (CD _PROT_))) (PP (IN in) (NP (DT a) (NN STAT3) (NN phosphorylation) (NN assay)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJR higher) (NN binding) (NN affinity)) (PP (IN for) (NP (JJ immobilized) (NN _PROT1_)))) (, ,) (SBAR (IN as) (S (VP (VBN determined) (PP (IN by) (NP (NP (JJ biosensor) (NN analysis)) (VP (VBG employing) (NP (NP (NN surface) (NN plasmon) (NN resonance)) (NN detection))))))))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (CD _PROT2_))) (PP (IN in) (NP (DT a) (NN STAT3) (NN phosphorylation) (NN assay)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJR higher) (NN binding) (NN affinity)) (PP (IN for) (NP (JJ immobilized) (NN _PROT_)))) (, ,) (SBAR (IN as) (S (VP (VBN determined) (PP (IN by) (NP (NP (JJ biosensor) (NN analysis)) (VP (VBG employing) (NP (NP (NN surface) (NN plasmon) (NN resonance)) (NN detection))))))))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (CD _PROT2_))) (PP (IN in) (NP (DT a) (NN STAT3) (NN phosphorylation) (NN assay)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (VBN increased) (NN binding) (NN affinity)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VBP cross-link) (NP (NP (CD two) (JJ _PROT2_) (NNS molecules)) (PP (IN on) (NP (DT the) (NN biosensor) (NN surface))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT1_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT1_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT1_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT1_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ ternary) (NN complex) (NN formation)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (VBN reduced) (JJ biological) (NN potency)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN from) (NP (NP (DT a) (VBN decreased) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (CD 2) (NN complex))) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NP (DT the) (JJ soluble) (NN portion)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN dimerization)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN dimerization)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN dimerization)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT2_) (NN _PROT_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN dimerization)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN dimerization)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN dimerization)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT2_) (NN _PROT_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN dimerization)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN dimerization)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT2_) (NN _PROT_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN dimerization)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT2_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN dimerization)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (RB not) (NP (NP (DT the) (VBG driving) (NN force)) (PP (IN in) (S (VP (VBG promoting) (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (ADJP (ADJP (JJ hexameric)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT1_) (NN _PROT2_)) (-RRB- -RRB-))) (CD 2) (NN complex))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT A) (NN model)) (VP (VBZ is) (VP (VBN presented) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (DT the) (JJ trimeric) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBZ forms) (PP (IN before) (NP (DT the) (JJ functional) (NN hexamer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (NN model)) (VP (VBZ is) (VP (VBN presented) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (DT the) (JJ trimeric) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBZ forms) (PP (IN before) (NP (DT the) (JJ functional) (NN hexamer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (NN model)) (VP (VBZ is) (VP (VBN presented) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (DT the) (JJ trimeric) (NN complex)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBZ forms) (PP (IN before) (NP (DT the) (JJ functional) (NN hexamer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (JJ Due) (TO to) (NP (NP (NP (PRP$ its) (VBN increased) (NN affinity)) (PP (IN for) (NP (DT the) (NN _PROT1_)))) (CC but) (NP (NP (PRP$ its) (VBN decreased) (NN ability)) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NN _PROT2_))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT a) (JJ stable) (NN _PROT_) (NN dimer)) (VP (MD may) (VP (VB be) (NP (DT an) (JJ efficient) (NN _PROT_) (NN antagonist)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (JJ Due) (TO to) (NP (NP (NP (PRP$ its) (VBN increased) (NN affinity)) (PP (IN for) (NP (DT the) (NN _PROT1_)))) (CC but) (NP (NP (PRP$ its) (VBN decreased) (NN ability)) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NN _PROT_))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT a) (JJ stable) (NN _PROT2_) (NN dimer)) (VP (MD may) (VP (VB be) (NP (DT an) (JJ efficient) (NN _PROT_) (NN antagonist)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (JJ Due) (TO to) (NP (NP (NP (PRP$ its) (VBN increased) (NN affinity)) (PP (IN for) (NP (DT the) (NN _PROT1_)))) (CC but) (NP (NP (PRP$ its) (VBN decreased) (NN ability)) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NN _PROT_))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT a) (JJ stable) (NN _PROT_) (NN dimer)) (VP (MD may) (VP (VB be) (NP (DT an) (JJ efficient) (NN _PROT2_) (NN antagonist)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (JJ Due) (TO to) (NP (NP (NP (PRP$ its) (VBN increased) (NN affinity)) (PP (IN for) (NP (DT the) (NN _PROT_)))) (CC but) (NP (NP (PRP$ its) (VBN decreased) (NN ability)) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NN _PROT1_))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT a) (JJ stable) (NN _PROT2_) (NN dimer)) (VP (MD may) (VP (VB be) (NP (DT an) (JJ efficient) (NN _PROT_) (NN antagonist)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (JJ Due) (TO to) (NP (NP (NP (PRP$ its) (VBN increased) (NN affinity)) (PP (IN for) (NP (DT the) (NN _PROT_)))) (CC but) (NP (NP (PRP$ its) (VBN decreased) (NN ability)) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NN _PROT1_))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT a) (JJ stable) (NN _PROT_) (NN dimer)) (VP (MD may) (VP (VB be) (NP (DT an) (JJ efficient) (NN _PROT2_) (NN antagonist)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (JJ Due) (TO to) (NP (NP (NP (PRP$ its) (VBN increased) (NN affinity)) (PP (IN for) (NP (DT the) (NN _PROT_)))) (CC but) (NP (NP (PRP$ its) (VBN decreased) (NN ability)) (S (VP (TO to) (VP (VB couple) (PP (IN with) (NP (NN _PROT_))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT a) (JJ stable) (NN _PROT1_) (NN dimer)) (VP (MD may) (VP (VB be) (NP (DT an) (JJ efficient) (NN _PROT2_) (NN antagonist)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN assembly)))) (, ,))) (PP (IN with) (NP (NP (NN heat) (NN shock) (NNS proteins)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN assembly)))) (, ,))) (PP (IN with) (NP (NP (NN heat) (NN shock) (NNS proteins)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN assembly)))) (, ,))) (PP (IN with) (NP (NP (NN heat) (NN shock) (NNS proteins)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN assembly)))) (, ,))) (PP (IN with) (NP (NP (NN heat) (NN shock) (NNS proteins)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN assembly)))) (, ,))) (PP (IN with) (NP (NP (NN heat) (NN shock) (NNS proteins)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN assembly)))) (, ,))) (PP (IN with) (NP (NP (NN heat) (NN shock) (NNS proteins)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Previous) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS complexes))))) (ADVP (FW in) (FW vitro))) (VP (VBP have) (VP (VBN suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN assembly)) (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ dynamic)) (, ,) (ADJP (VBN ordered))) (NN process)) (VP (VBG involving) (NP (QP (IN at) (JJS least) (CD eight)) (JJ nonreceptor) (NNS proteins)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Previous) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NNS complexes))))) (ADVP (FW in) (FW vitro))) (VP (VBP have) (VP (VBN suggested) (SBAR (IN that) (S (NP (NN _PROT2_) (NN assembly)) (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ dynamic)) (, ,) (ADJP (VBN ordered))) (NN process)) (VP (VBG involving) (NP (QP (IN at) (JJS least) (CD eight)) (JJ nonreceptor) (NNS proteins)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Previous) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NNS complexes))))) (ADVP (FW in) (FW vitro))) (VP (VBP have) (VP (VBN suggested) (SBAR (IN that) (S (NP (NN _PROT2_) (NN assembly)) (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ dynamic)) (, ,) (ADJP (VBN ordered))) (NN process)) (VP (VBG involving) (NP (QP (IN at) (JJS least) (CD eight)) (JJ nonreceptor) (NNS proteins)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (CD One)) (PP (IN of) (NP (DT these) (NNS proteins)))) (, ,) (NP (NN _PROT1_)) (, ,)) (VP (VP (VBZ appears) (ADVP (RB transiently)) (PP (IN during) (NP (NN assembly)))) (CC and) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (ADJP (RB functionally) (JJ mature)) (NN _PROT2_) (NNS complexes))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT2_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT1_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBP observe) (SBAR (IN that) (S (NP (NP (DT a) (JJ monoclonal) (NN antibody)) (ADJP (JJ specific) (PP (IN for) (NP (NN _PROT_))))) (VP (VP (MD can) (, ,) (PP (IN on) (NP (DT the) (CD one) (NN hand))) (, ,) (VP (VB inhibit) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS immunophilins))))))))) (CC and) (, ,) (PP (IN on) (NP (DT the) (JJ other))) (, ,) (VP (VBP enhance) (NP (NP (NN recovery)) (PP (IN of) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN observation)) (VP (VBZ supports) (NP (NP (DT a) (NN model)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN at) (NP (NP (DT an) (JJ intermediate) (NN stage)) (PP (IN of) (NP (NN _PROT2_) (NN assembly))))) (S (VP (TO to) (VP (VB facilitate) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ subsequent) (NN _PROT_) (NNS complexes)) (VP (VBG lacking) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN observation)) (VP (VBZ supports) (NP (NP (DT a) (NN model)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN at) (NP (NP (DT an) (JJ intermediate) (NN stage)) (PP (IN of) (NP (NN _PROT_) (NN assembly))))) (S (VP (TO to) (VP (VB facilitate) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ subsequent) (NN _PROT2_) (NNS complexes)) (VP (VBG lacking) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN observation)) (VP (VBZ supports) (NP (NP (DT a) (NN model)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN at) (NP (NP (DT an) (JJ intermediate) (NN stage)) (PP (IN of) (NP (NN _PROT_) (NN assembly))))) (S (VP (TO to) (VP (VB facilitate) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ subsequent) (NN _PROT_) (NNS complexes)) (VP (VBG lacking) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN observation)) (VP (VBZ supports) (NP (NP (DT a) (NN model)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ functions) (PP (IN at) (NP (NP (DT an) (JJ intermediate) (NN stage)) (PP (IN of) (NP (NN _PROT1_) (NN assembly))))) (S (VP (TO to) (VP (VB facilitate) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ subsequent) (NN _PROT2_) (NNS complexes)) (VP (VBG lacking) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN observation)) (VP (VBZ supports) (NP (NP (DT a) (NN model)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ functions) (PP (IN at) (NP (NP (DT an) (JJ intermediate) (NN stage)) (PP (IN of) (NP (NN _PROT1_) (NN assembly))))) (S (VP (TO to) (VP (VB facilitate) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ subsequent) (NN _PROT_) (NNS complexes)) (VP (VBG lacking) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN observation)) (VP (VBZ supports) (NP (NP (DT a) (NN model)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ functions) (PP (IN at) (NP (NP (DT an) (JJ intermediate) (NN stage)) (PP (IN of) (NP (NN _PROT_) (NN assembly))))) (S (VP (TO to) (VP (VB facilitate) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ subsequent) (NN _PROT1_) (NNS complexes)) (VP (VBG lacking) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB typically)) (VP (VBN found) (PP (IN in) (NP (NP (DT a) (NN complex)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (ADVP (RB further)) (VP (VBN characterized) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (DT these) (NNS proteins))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB typically)) (VP (VBN found) (PP (IN in) (NP (NP (DT a) (NN complex)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (ADVP (RB further)) (VP (VBN characterized) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (DT these) (NNS proteins))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB typically)) (VP (VBN found) (PP (IN in) (NP (NP (DT a) (NN complex)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (ADVP (RB further)) (VP (VBN characterized) (NP (NP (PRP$ its) (NNS interactions)) (PP (IN with) (NP (DT these) (NNS proteins))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB bind) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (UCP (ADVP (RB independently)) (CC and) (PP (IN in) (NP (DT an) (JJ ATP-independent) (NN manner))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB bind) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (UCP (ADVP (RB independently)) (CC and) (PP (IN in) (NP (DT an) (JJ ATP-independent) (NN manner))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (MD can) (VP (VB bind) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (UCP (ADVP (RB independently)) (CC and) (PP (IN in) (NP (DT an) (JJ ATP-independent) (NN manner))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT1_AND_PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT1_AND_PROT2_) (NN complex))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Since) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP do) (RB not) (ADVP (RB readily)) (VP (VB associate) (PP (IN on) (NP (PRP$ their) (JJ own))))))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT the) (JJ central) (NN organizing) (NN component)) (PP (IN of) (NP (DT an) (NN _PROT1_AND_PROT2_) (NN complex))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Mutational) (NN analysis)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ indicates) (SBAR (IN that) (S (S (NP (DT the) (NN N) (NN terminus)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN binding)))))) (, ,) (CC and) (S (NP (NP (DT a) (JJ central) (NN region)) (VP (VBG containing) (NP (NN tetratricopeptide) (NN repeat) (NNS motifs)))) (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Mutational) (NN analysis)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ indicates) (SBAR (IN that) (S (S (NP (DT the) (NN N) (NN terminus)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN binding)))))) (, ,) (CC and) (S (NP (NP (DT a) (JJ central) (NN region)) (VP (VBG containing) (NP (NN tetratricopeptide) (NN repeat) (NNS motifs)))) (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Mutational) (NN analysis)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ indicates) (SBAR (IN that) (S (S (NP (DT the) (NN N) (NN terminus)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN binding)))))) (, ,) (CC and) (S (NP (NP (DT a) (JJ central) (NN region)) (VP (VBG containing) (NP (NN tetratricopeptide) (NN repeat) (NNS motifs)))) (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Mutational) (NN analysis)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ indicates) (SBAR (IN that) (S (S (NP (DT the) (NN N) (NN terminus)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NN _PROT1_) (NN binding)))))) (, ,) (CC and) (S (NP (NP (DT a) (JJ central) (NN region)) (VP (VBG containing) (NP (NN tetratricopeptide) (NN repeat) (NNS motifs)))) (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Mutational) (NN analysis)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ indicates) (SBAR (IN that) (S (S (NP (DT the) (NN N) (NN terminus)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NN _PROT1_) (NN binding)))))) (, ,) (CC and) (S (NP (NP (DT a) (JJ central) (NN region)) (VP (VBG containing) (NP (NN tetratricopeptide) (NN repeat) (NNS motifs)))) (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Mutational) (NN analysis)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ indicates) (SBAR (IN that) (S (S (NP (DT the) (NN N) (NN terminus)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN binding)))))) (, ,) (CC and) (S (NP (NP (DT a) (JJ central) (NN region)) (VP (VBG containing) (NP (NN tetratricopeptide) (NN repeat) (NNS motifs)))) (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_AND_PROT2_) (NN multichaperone) (NN complex)) (VP (VP (VBZ is) (ADVP (RB highly)) (ADJP (JJ dynamic))) (CC and) (VP (VBZ does) (RB not) (VP (VB appear) (S (VP (TO to) (VP (VB be) (VP (VBN affected) (PP (IN by) (NP (DT the) (JJ _PROT_) (NN drug) (NN geldanamycin))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_AND_PROT2_) (NN multichaperone) (NN complex)) (VP (VP (VBZ is) (ADVP (RB highly)) (ADJP (JJ dynamic))) (CC and) (VP (VBZ does) (RB not) (VP (VB appear) (S (VP (TO to) (VP (VB be) (VP (VBN affected) (PP (IN by) (NP (DT the) (JJ _PROT_) (NN drug) (NN geldanamycin))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN multichaperone) (NN complex)) (VP (VP (VBZ is) (ADVP (RB highly)) (ADJP (JJ dynamic))) (CC and) (VP (VBZ does) (RB not) (VP (VB appear) (S (VP (TO to) (VP (VB be) (VP (VBN affected) (PP (IN by) (NP (DT the) (JJ _PROT2_) (NN drug) (NN geldanamycin))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_AND_PROT2_) (NN multichaperone) (NN complex)) (VP (VP (VBZ is) (ADVP (RB highly)) (ADJP (JJ dynamic))) (CC and) (VP (VBZ does) (RB not) (VP (VB appear) (S (VP (TO to) (VP (VB be) (VP (VBN affected) (PP (IN by) (NP (DT the) (JJ _PROT_) (NN drug) (NN geldanamycin))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN multichaperone) (NN complex)) (VP (VP (VBZ is) (ADVP (RB highly)) (ADJP (JJ dynamic))) (CC and) (VP (VBZ does) (RB not) (VP (VB appear) (S (VP (TO to) (VP (VB be) (VP (VBN affected) (PP (IN by) (NP (DT the) (JJ _PROT2_) (NN drug) (NN geldanamycin))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN multichaperone) (NN complex)) (VP (VP (VBZ is) (ADVP (RB highly)) (ADJP (JJ dynamic))) (CC and) (VP (VBZ does) (RB not) (VP (VB appear) (S (VP (TO to) (VP (VB be) (VP (VBN affected) (PP (IN by) (NP (DT the) (JJ _PROT2_) (NN drug) (NN geldanamycin))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT2_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT2_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT1_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT1_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT1_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT1_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT1_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN intermediate) (NN _PROT_) (NNS complexes)))) (VP (VBP are) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ distinct) (PP (IN from) (NP (NP (PRP$ their) (JJ separate) (NNS interactions)) (PP (PP (IN in) (NP (NP (JJ early) (NN _PROT_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (CC or) (PP (IN in) (NP (NP (JJ mature) (NN _PROT2_) (NNS complexes)) (PRN (-LRB- -LRB-) (NP (NN hsp90)) (-RRB- -RRB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (, ,) (NP (PRP it)) (VP (VBZ appears) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ key) (NN mediator)) (PP (IN in) (NP (NP (DT the) (VBN chaperoned) (NP (NP (NN assembly)) (CC and) (NP (JJ functional) (NN maturation)))) (PP (IN of) (NP (NN _PROT2_) (NNS complexes))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ prevents) (NP (NP (NP (NN _PROT2_) (NN containing) (NN _PROT_) (NNS complexes)) (NN formation)) (PP (IN in) (NP (ADJP (RB terminally) (VBN differentiated)) (NNS myocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ prevents) (NP (NP (NP (NN _PROT2_) (NN containing) (NN _PROT_) (NNS complexes)) (NN formation)) (PP (IN in) (NP (ADJP (RB terminally) (VBN differentiated)) (NNS myocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ prevents) (NP (NP (NP (NN _PROT_) (NN containing) (NN _PROT2_) (NNS complexes)) (NN formation)) (PP (IN in) (NP (ADJP (RB terminally) (VBN differentiated)) (NNS myocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ prevents) (NP (NP (NP (NN _PROT1_AND_PROT2_) (NN containing) (NN _PROT_) (NNS complexes)) (NN formation)) (PP (IN in) (NP (ADJP (RB terminally) (VBN differentiated)) (NNS myocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ prevents) (NP (NP (NP (NN _PROT1_) (NN containing) (NN _PROT2_) (NNS complexes)) (NN formation)) (PP (IN in) (NP (ADJP (RB terminally) (VBN differentiated)) (NNS myocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ prevents) (NP (NP (NP (NN _PROT1_) (NN containing) (NN _PROT2_) (NNS complexes)) (NN formation)) (PP (IN in) (NP (ADJP (RB terminally) (VBN differentiated)) (NNS myocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (-LRB- -LRB-) (JJ _PROT2_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT2_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT1_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT2_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT1_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT1_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT1_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT1_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT1_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT1_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT1_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT1_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Withdrawal)) (PP (IN from) (NP (DT the) (NN cell) (NN cycle))) (PP (IN of) (NP (JJ differentiating) (NNS myocytes)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (JJ _PROT_) (-LRB- -LRB-) (JJ _PROT_) (-RRB- -RRB-) (NN protein)) (NP (NN _PROT_))) (CC and) (NP (NP (DT the) (NN pocket) (NNS proteins)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT1_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT1_AND_PROT2_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT1_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT1_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT1_)) (VP (VBG containing) (NP (NP (NP (NN _PROT2_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT1_)) (VP (VBG containing) (NP (NP (NP (NN _PROT_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT An) (NN _PROT_) (NN complex)) (VP (VBG containing) (ADVP (RB mainly)) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN complex)) (-RRB- -RRB-)))))) (VP (VBZ appears) (SBAR (WHADVP (WRB when)) (S (NP (NN DNA) (NN synthesis)) (VP (VBZ arrests)) (, ,) (VP (VBG replacing) (NP (NP (DT the) (NN _PROT_)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_) (NN complex)) (PP (IN of) (NP (VBG proliferating) (NNS myoblasts)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN complex)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ differentiating) (NN C2C12) (NNS cells))) (, ,) (NP (NP (NP (NN _PROT1_) (NNS complexes)) (NP (NP (NN switch)) (CC and) (NP (NN DNA) (NN synthesis)))) (PP (IN in) (NN response) (TO to) (NP (NN serum)))) (VP (VBP are) (VP (VBN prevented) (SBAR (WHADVP (WRB when)) (S (NP (NP (NN _PROT2_) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (DT the) (NN cdks) (NN inhibitor) (NN _PROT_) (JJ downstream) (NN effector) (NN _PROT_))) (VP (VBP are) (VP (VBN induced))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ differentiating) (NN C2C12) (NNS cells))) (, ,) (NP (NP (NP (NN _PROT1_) (NNS complexes)) (NP (NP (NN switch)) (CC and) (NP (NN DNA) (NN synthesis)))) (PP (IN in) (NN response) (TO to) (NP (NN serum)))) (VP (VBP are) (VP (VBN prevented) (SBAR (WHADVP (WRB when)) (S (NP (NP (NN _PROT_) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (DT the) (NN cdks) (NN inhibitor) (NN _PROT2_) (JJ downstream) (NN effector) (NN _PROT_))) (VP (VBP are) (VP (VBN induced))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ differentiating) (NN C2C12) (NNS cells))) (, ,) (NP (NP (NP (NN _PROT1_) (NNS complexes)) (NP (NP (NN switch)) (CC and) (NP (NN DNA) (NN synthesis)))) (PP (IN in) (NN response) (TO to) (NP (NN serum)))) (VP (VBP are) (VP (VBN prevented) (SBAR (WHADVP (WRB when)) (S (NP (NP (NN _PROT_) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (DT the) (NN cdks) (NN inhibitor) (NN _PROT_) (JJ downstream) (NN effector) (NN _PROT2_))) (VP (VBP are) (VP (VBN induced))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ differentiating) (NN C2C12) (NNS cells))) (, ,) (NP (NP (NP (NN _PROT_) (NNS complexes)) (NP (NP (NN switch)) (CC and) (NP (NN DNA) (NN synthesis)))) (PP (IN in) (NN response) (TO to) (NP (NN serum)))) (VP (VBP are) (VP (VBN prevented) (SBAR (WHADVP (WRB when)) (S (NP (NP (NN _PROT1_) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (DT the) (NN cdks) (NN inhibitor) (NN _PROT2_) (JJ downstream) (NN effector) (NN _PROT_))) (VP (VBP are) (VP (VBN induced))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ differentiating) (NN C2C12) (NNS cells))) (, ,) (NP (NP (NP (NN _PROT_) (NNS complexes)) (NP (NP (NN switch)) (CC and) (NP (NN DNA) (NN synthesis)))) (PP (IN in) (NN response) (TO to) (NP (NN serum)))) (VP (VBP are) (VP (VBN prevented) (SBAR (WHADVP (WRB when)) (S (NP (NP (NN _PROT1_) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (DT the) (NN cdks) (NN inhibitor) (NN _PROT_) (JJ downstream) (NN effector) (NN _PROT2_))) (VP (VBP are) (VP (VBN induced))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ differentiating) (NN C2C12) (NNS cells))) (, ,) (NP (NP (NP (NN _PROT_) (NNS complexes)) (NP (NP (NN switch)) (CC and) (NP (NN DNA) (NN synthesis)))) (PP (IN in) (NN response) (TO to) (NP (NN serum)))) (VP (VBP are) (VP (VBN prevented) (SBAR (WHADVP (WRB when)) (S (NP (NP (NN _PROT_) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (DT the) (NN cdks) (NN inhibitor) (NN _PROT1_) (JJ downstream) (NN effector) (NN _PROT2_))) (VP (VBP are) (VP (VBN induced))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (JJ myogenic) (NN differentiation))) (, ,) (NP (NP (NN formation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN containing) (NNS complexes))))) (VP (VP (VBZ is) (NP (DT an) (JJ early) (NN event))) (, ,) (CC but) (RB not) (ADVP (RB enough)) (PP (IN on) (NP (PRP$ its) (JJ own))) (S (VP (TO to) (VP (VB prevent) (NP (NP (DT the) (NN reactivation)) (PP (IN of) (NP (NN DNA) (NN synthesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (JJ myogenic) (NN differentiation))) (, ,) (NP (NP (NN formation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN containing) (NNS complexes))))) (VP (VP (VBZ is) (NP (DT an) (JJ early) (NN event))) (, ,) (CC but) (RB not) (ADVP (RB enough)) (PP (IN on) (NP (PRP$ its) (JJ own))) (S (VP (TO to) (VP (VB prevent) (NP (NP (DT the) (NN reactivation)) (PP (IN of) (NP (NN DNA) (NN synthesis)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (JJ myogenic) (NN differentiation))) (, ,) (NP (NP (NN formation)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN containing) (NNS complexes))))) (VP (VP (VBZ is) (NP (DT an) (JJ early) (NN event))) (, ,) (CC but) (RB not) (ADVP (RB enough)) (PP (IN on) (NP (PRP$ its) (JJ own))) (S (VP (TO to) (VP (VB prevent) (NP (NP (DT the) (NN reactivation)) (PP (IN of) (NP (NN DNA) (NN synthesis)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT2_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT2_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT2_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT2_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT1_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT1_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT1_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT1_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN subclone)) (PP (IN of) (NP (NP (NN C3H10T1/2) (NN mouse) (NNS fibroblasts)) (VP (ADVP (RB stably)) (VBG expressing) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN chimerae)))))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (S (NP (NN estrogen) (JJ directed) (NN _PROT_) (NN activation)) (VP (VBZ prevents) (NP (NP (DT the) (NN reassociation)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN containing) (NN complex)))) (PP (VBG following) (NP (NN serum) (NN stimulation))))) (CC and) (S (NP (DT this)) (VP (VBZ correlates) (PP (IN with) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NN _PROT2_) (NN activity)))) (CC and) (NP (NP (DT the) (NN inability)) (PP (IN of) (NP (NNS cells))) (S (VP (TO to) (VP (VB re-enter) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (JJ differentiating) (NNS myocytes))) (, ,) (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (JJ permanent) (NN cell) (NN cycle) (NN arrest)))))) (VP (VBZ involves) (NP (NP (NN _PROT2_) (NN upregulation)) (CC and) (NP (NP (NN suppression)) (PP (IN of) (NP (DT the) (JJ proliferation-associated) (JJ cdks-containing) (NN _PROT_) (NNS complexes)))) (NP (NN formation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (JJ differentiating) (NNS myocytes))) (, ,) (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (JJ permanent) (NN cell) (NN cycle) (NN arrest)))))) (VP (VBZ involves) (NP (NP (NN _PROT_) (NN upregulation)) (CC and) (NP (NP (NN suppression)) (PP (IN of) (NP (DT the) (JJ proliferation-associated) (JJ cdks-containing) (NN _PROT2_) (NNS complexes)))) (NP (NN formation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (JJ differentiating) (NNS myocytes))) (, ,) (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ induces) (NP (JJ permanent) (NN cell) (NN cycle) (NN arrest)))))) (VP (VBZ involves) (NP (NP (NN _PROT1_) (NN upregulation)) (CC and) (NP (NP (NN suppression)) (PP (IN of) (NP (DT the) (JJ proliferation-associated) (JJ cdks-containing) (NN _PROT2_) (NNS complexes)))) (NP (NN formation)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT2_) (NN activity)) (PP (IN by) (NP (NP (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT_) (JJ cysteine-rich) (NN domain))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT_) (NN activity)) (PP (IN by) (NP (NP (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT2_) (JJ cysteine-rich) (NN domain))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT1_) (NN activity)) (PP (IN by) (NP (NP (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT2_) (JJ cysteine-rich) (NN domain))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN effector)) (PP (IN of) (NP (NP (NN _PROT2_) (NN signaling)) (CC and) (NP (NN transformation)))))))) (, ,) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ promotes) (NP (NN _PROT_) (NN activation)))))) (VP (VP (VBZ is) (ADJP (JJ complex))) (CC and) (VP (VBZ remains) (ADVP (RB poorly)) (VP (VBN understood))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN effector)) (PP (IN of) (NP (NP (NN _PROT_) (NN signaling)) (CC and) (NP (NN transformation)))))))) (, ,) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ promotes) (NP (NN _PROT_) (NN activation)))))) (VP (VP (VBZ is) (ADJP (JJ complex))) (CC and) (VP (VBZ remains) (ADVP (RB poorly)) (VP (VBN understood))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN effector)) (PP (IN of) (NP (NP (NN _PROT_) (NN signaling)) (CC and) (NP (NN transformation)))))))) (, ,) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ promotes) (NP (NN _PROT2_) (NN activation)))))) (VP (VP (VBZ is) (ADJP (JJ complex))) (CC and) (VP (VBZ remains) (ADVP (RB poorly)) (VP (VBN understood))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN effector)) (PP (IN of) (NP (NP (NN _PROT1_) (NN signaling)) (CC and) (NP (NN transformation)))))))) (, ,) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ promotes) (NP (NN _PROT_) (NN activation)))))) (VP (VP (VBZ is) (ADJP (JJ complex))) (CC and) (VP (VBZ remains) (ADVP (RB poorly)) (VP (VBN understood))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN effector)) (PP (IN of) (NP (NP (NN _PROT1_) (NN signaling)) (CC and) (NP (NN transformation)))))))) (, ,) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ promotes) (NP (NN _PROT2_) (NN activation)))))) (VP (VP (VBZ is) (ADJP (JJ complex))) (CC and) (VP (VBZ remains) (ADVP (RB poorly)) (VP (VBN understood))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN effector)) (PP (IN of) (NP (NP (NN _PROT_) (NN signaling)) (CC and) (NP (NN transformation)))))))) (, ,) (NP (NP (DT the) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ promotes) (NP (NN _PROT2_) (NN activation)))))) (VP (VP (VBZ is) (ADJP (JJ complex))) (CC and) (VP (VBZ remains) (ADVP (RB poorly)) (VP (VBN understood))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN activation)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN activation)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB recently)) (VP (VBD reported) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NNS residues) (CD 139-184))) (-RRB- -RRB-))))) (VP (MD may) (VP (VB be) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_)) (VP (VP (VBZ is) (ADJP (JJ located) (PP (IN in) (NP (NP (DT the) (JJ NH2-terminal) (JJ negative) (JJ regulatory) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (VP (VBZ is) (ADJP (RB highly) (JJ homologous) (PP (TO to) (NP (NP (JJ cysteine-rich) (NNS domains)) (VP (VBN found) (PP (IN in) (NP (NP (NN protein) (NN kinase) (NN C)) (NN family) (NNS members)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recent) (NNS studies)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ structural) (NN integrity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADVP (RB also)) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN _PROT2_) (NN interaction)) (PP (IN with) (NP (NN 14-3-3) (NNS proteins))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (SBAR (SBAR (IN whether) (S (NP (NN 14-3-3) (NNS proteins)) (VP (VBP interact) (ADVP (RB directly)) (PP (IN with) (NP (DT the) (NN _PROT1_)))))) (CC and) (SBAR (WHADVP (WRB how)) (S (NP (DT this) (NN interaction)) (VP (MD may) (VP (VB mediate) (NP (NN _PROT2_) (NN function))))))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN determined))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (VBN isolated) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (NN mutation)) (PP (IN of) (NP (NN _PROT1_) (NNS residues) (CD 143-145)))) (VP (VBZ impairs) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN 14-3-3)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,))) (PP (TO to) (NP (DT the) (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (NN mutation)) (PP (IN of) (NP (NN _PROT1_) (NNS residues) (CD 143-145)))) (VP (VBZ impairs) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN 14-3-3)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,))) (PP (TO to) (NP (DT the) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (NN mutation)) (PP (IN of) (NP (NN _PROT_) (NNS residues) (CD 143-145)))) (VP (VBZ impairs) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN 14-3-3)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)) (, ,))) (PP (TO to) (NP (DT the) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN 14-3-3) (NN interaction)) (PP (IN with) (NP (DT the) (NN _PROT1_)))) (VP (MD may) (VP (VB serve) (PP (IN in) (NP (NP (JJ negative) (NN regulation)) (PP (IN of) (NP (NN _PROT2_) (NN function))) (PP (IN by) (S (VP (VBG facilitating) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN 14-3-3))) (PP (IN from) (NP (NP (DT the) (NN NH2) (NN terminus)) (PP (IN of) (NP (NN _PROT_)))))) (S (VP (TO to) (VP (VB promote) (NP (NP (JJ subsequent) (NNS events)) (ADJP (JJ necessary) (PP (IN for) (NP (NP (JJ full) (NN activation)) (PP (IN of) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN 14-3-3) (NN interaction)) (PP (IN with) (NP (DT the) (NN _PROT1_)))) (VP (MD may) (VP (VB serve) (PP (IN in) (NP (NP (JJ negative) (NN regulation)) (PP (IN of) (NP (NN _PROT_) (NN function))) (PP (IN by) (S (VP (VBG facilitating) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN 14-3-3))) (PP (IN from) (NP (NP (DT the) (NN NH2) (NN terminus)) (PP (IN of) (NP (NN _PROT2_)))))) (S (VP (TO to) (VP (VB promote) (NP (NP (JJ subsequent) (NNS events)) (ADJP (JJ necessary) (PP (IN for) (NP (NP (JJ full) (NN activation)) (PP (IN of) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN 14-3-3) (NN interaction)) (PP (IN with) (NP (DT the) (NN _PROT1_)))) (VP (MD may) (VP (VB serve) (PP (IN in) (NP (NP (JJ negative) (NN regulation)) (PP (IN of) (NP (NN _PROT_) (NN function))) (PP (IN by) (S (VP (VBG facilitating) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN 14-3-3))) (PP (IN from) (NP (NP (DT the) (NN NH2) (NN terminus)) (PP (IN of) (NP (NN _PROT_)))))) (S (VP (TO to) (VP (VB promote) (NP (NP (JJ subsequent) (NNS events)) (ADJP (JJ necessary) (PP (IN for) (NP (NP (JJ full) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN 14-3-3) (NN interaction)) (PP (IN with) (NP (DT the) (NN _PROT_)))) (VP (MD may) (VP (VB serve) (PP (IN in) (NP (NP (JJ negative) (NN regulation)) (PP (IN of) (NP (NN _PROT1_) (NN function))) (PP (IN by) (S (VP (VBG facilitating) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN 14-3-3))) (PP (IN from) (NP (NP (DT the) (NN NH2) (NN terminus)) (PP (IN of) (NP (NN _PROT2_)))))) (S (VP (TO to) (VP (VB promote) (NP (NP (JJ subsequent) (NNS events)) (ADJP (JJ necessary) (PP (IN for) (NP (NP (JJ full) (NN activation)) (PP (IN of) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN 14-3-3) (NN interaction)) (PP (IN with) (NP (DT the) (NN _PROT_)))) (VP (MD may) (VP (VB serve) (PP (IN in) (NP (NP (JJ negative) (NN regulation)) (PP (IN of) (NP (NN _PROT1_) (NN function))) (PP (IN by) (S (VP (VBG facilitating) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN 14-3-3))) (PP (IN from) (NP (NP (DT the) (NN NH2) (NN terminus)) (PP (IN of) (NP (NN _PROT_)))))) (S (VP (TO to) (VP (VB promote) (NP (NP (JJ subsequent) (NNS events)) (ADJP (JJ necessary) (PP (IN for) (NP (NP (JJ full) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN 14-3-3) (NN interaction)) (PP (IN with) (NP (DT the) (NN _PROT_)))) (VP (MD may) (VP (VB serve) (PP (IN in) (NP (NP (JJ negative) (NN regulation)) (PP (IN of) (NP (NN _PROT_) (NN function))) (PP (IN by) (S (VP (VBG facilitating) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN 14-3-3))) (PP (IN from) (NP (NP (DT the) (NN NH2) (NN terminus)) (PP (IN of) (NP (NN _PROT1_)))))) (S (VP (TO to) (VP (VB promote) (NP (NP (JJ subsequent) (NNS events)) (ADJP (JJ necessary) (PP (IN for) (NP (NP (JJ full) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (JJ Soluble) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (JJ toxic) (JJ epidermal) (NNS necrolysis)))) (: :) (NP (NP (DT a) (JJ comparative) (NN analysis)) (PP (IN of) (NP (NP (NP (NN serum)) (CC and) (NP (NN blister) (NN fluid))) (NNS samples)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (JJ Soluble) (NN _PROT1_) (CD _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (JJ toxic) (JJ epidermal) (NNS necrolysis)))) (: :) (NP (NP (DT a) (JJ comparative) (NN analysis)) (PP (IN of) (NP (NP (NP (NN serum)) (CC and) (NP (NN blister) (NN fluid))) (NNS samples)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (JJ Soluble) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (JJ toxic) (JJ epidermal) (NNS necrolysis)))) (: :) (NP (NP (DT a) (JJ comparative) (NN analysis)) (PP (IN of) (NP (NP (NP (NN serum)) (CC and) (NP (NN blister) (NN fluid))) (NNS samples)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ MAIN) (NN OUTCOME) (NNS MEASURES)) (: :) (NP (NP (NP (NN Measurement)) (PP (IN of) (NP (NP (NP (NP (JJ soluble) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (CC and) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (NN serum) (NNS samples) (CC and) (NP (NN fluid))) (PP (IN of) (NP (JJ recent) (NNS blisters))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ MAIN) (NN OUTCOME) (NNS MEASURES)) (: :) (NP (NP (NP (NN Measurement)) (PP (IN of) (NP (NP (NP (NP (JJ soluble) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (CC and) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NN serum) (NNS samples) (CC and) (NP (NN fluid))) (PP (IN of) (NP (JJ recent) (NNS blisters))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ MAIN) (NN OUTCOME) (NNS MEASURES)) (: :) (NP (NP (NP (NN Measurement)) (PP (IN of) (NP (NP (NP (NP (JJ soluble) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (CC and) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NN serum) (NNS samples) (CC and) (NP (NN fluid))) (PP (IN of) (NP (JJ recent) (NNS blisters))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (PP (IN In) (NP (NP (DT the) (JJ blister) (NN fluid)) (PP (IN of) (NP (NP (NNS patients)) (PP (IN with) (NP (CD TEN))))))) (, ,) (NP (PRP we)) (VP (VBD found) (NP (NP (ADJP (RB significantly) (JJR higher)) (NNS levels)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN than) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (NN burns)))))) (, ,) (SBAR (IN whereas) (S (NP (NN _PROT2_) (NNS levels)) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN in) (NP (NP (DT the) (JJ blister) (NN fluid)) (PP (IN of) (NP (JJ burned) (NNS patients))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (DT No) (JJ significant) (NNS differences)) (VP (VBD were) (VP (VBN found) (PP (IN in) (NP (NP (NN serum) (NNS samples)) (PP (IN of) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (CD TEN)) (CC and) (NP (NN burns)))))))) (, ,) (PP (IN in) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (CD TEN))) (NP (PRP we)) (ADVP (RB also)) (VP (VBD found) (NP (NP (ADJP (RB significantly) (JJR higher)) (NNS levels)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT the) (NN blister) (NN fluid))) (PP (VBN compared) (PP (IN with) (NP (NN serum) (NNS samples)))) (, ,) (S (VP (VBG pointing) (PP (TO to) (NP (NP (DT a) (ADJP (RB predominantly) (JJ local)) (NN production)) (VP (VBG contrasting) (PP (IN with) (NP (NP (DT the) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (JJ blister) (NN fluid)) (PP (IN of) (NP (JJ burned) (NNS patients))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN overview)) (VP (VBZ summarizes) (NP (NP (DT the) (JJ current) (NN knowledge)) (PP (IN on) (NP (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN progression)) (PP (IN of) (NP (NN atherosclerosis)))))) (CC and) (NP (NP (DT the) (NN influence)) (PP (IN of) (NP (NN MMPs))) (PP (IN in) (NP (NN aneurysm) (NN formation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (DT a) (JJ possible) (NN role)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (NN product)) (PP (IN of) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)))) (, ,))) (PP (IN in) (NP (JJ atherosclerotic) (NN lesion) (NN development)))) (VP (VBZ is) (VP (VBP put) (PP (IN into) (NP (NN perspective)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ hereditary) (NN haemochromatosis) (NN protein) (NNS _PROT1_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ hereditary) (NN haemochromatosis) (NN protein) (NNS _PROT1_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ hereditary) (NN haemochromatosis) (NN protein) (NNS _PROT_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT a) (NN receptor)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NNS cells)) (VP (VBP acquire) (NP (JJ iron-loaded) (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (CD 2.8) (NN A) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (DT the) (JJ extracellular) (NNS portions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (VP (VBZ shows) (NP (NP (CD two) (NN _PROT_) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VB grasp) (NP (NP (DT each) (NN side)) (PP (IN of) (NP (DT a) (ADJP (RB twofold) (JJ symmetric)) (NN _PROT_) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (CD 2.8) (NN A) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (DT the) (JJ extracellular) (NNS portions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (VP (VBZ shows) (NP (NP (CD two) (NN _PROT2_) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VB grasp) (NP (NP (DT each) (NN side)) (PP (IN of) (NP (DT a) (ADJP (RB twofold) (JJ symmetric)) (NN _PROT_) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (CD 2.8) (NN A) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (DT the) (JJ extracellular) (NNS portions)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (VP (VBZ shows) (NP (NP (CD two) (NN _PROT_) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VB grasp) (NP (NP (DT each) (NN side)) (PP (IN of) (NP (DT a) (ADJP (RB twofold) (JJ symmetric)) (NN _PROT2_) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (CD 2.8) (NN A) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (DT the) (JJ extracellular) (NNS portions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (VP (VBZ shows) (NP (NP (CD two) (NN _PROT2_) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VB grasp) (NP (NP (DT each) (NN side)) (PP (IN of) (NP (DT a) (ADJP (RB twofold) (JJ symmetric)) (NN _PROT_) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (CD 2.8) (NN A) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (DT the) (JJ extracellular) (NNS portions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (VP (VBZ shows) (NP (NP (CD two) (NN _PROT_) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VB grasp) (NP (NP (DT each) (NN side)) (PP (IN of) (NP (DT a) (ADJP (RB twofold) (JJ symmetric)) (NN _PROT2_) (NN dimer))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (CD 2.8) (NN A) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN complex)) (PP (IN between) (NP (NP (DT the) (JJ extracellular) (NNS portions)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (VP (VBZ shows) (NP (NP (CD two) (NN _PROT1_) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VB grasp) (NP (NP (DT each) (NN side)) (PP (IN of) (NP (DT a) (ADJP (RB twofold) (JJ symmetric)) (NN _PROT2_) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN On) (NP (NP (DT a) (NN cell) (NN membrane)) (VP (VBG containing) (NP (DT both) (NNS proteins))))) (, ,) (NP (NN _PROT1_)) (VP (MD would) (VP (`` ') (VBP lie) (ADVP (RB down)) (ADJP (`` ') (JJ parallel) (PP (TO to) (NP (DT the) (NN membrane)))) (, ,) (SBAR (JJ such) (IN that) (S (NP (NP (DT the) (JJ _PROT2_) (NNS helices)) (SBAR (WHNP (WDT that)) (S (VP (VBP delineate) (NP (NP (DT the) (NN counterpart)) (PP (IN of) (NP (DT the) (NN MHC) (JJ peptide-binding) (NN groove)))))))) (VP (VBP make) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (NNS helices)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN dimerization) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN On) (NP (NP (DT a) (NN cell) (NN membrane)) (VP (VBG containing) (NP (DT both) (NNS proteins))))) (, ,) (NP (NN _PROT1_)) (VP (MD would) (VP (`` ') (VBP lie) (ADVP (RB down)) (ADJP (`` ') (JJ parallel) (PP (TO to) (NP (DT the) (NN membrane)))) (, ,) (SBAR (JJ such) (IN that) (S (NP (NP (DT the) (JJ _PROT_) (NNS helices)) (SBAR (WHNP (WDT that)) (S (VP (VBP delineate) (NP (NP (DT the) (NN counterpart)) (PP (IN of) (NP (DT the) (NN MHC) (JJ peptide-binding) (NN groove)))))))) (VP (VBP make) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (NNS helices)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN dimerization) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN On) (NP (NP (DT a) (NN cell) (NN membrane)) (VP (VBG containing) (NP (DT both) (NNS proteins))))) (, ,) (NP (NN _PROT_)) (VP (MD would) (VP (`` ') (VBP lie) (ADVP (RB down)) (ADJP (`` ') (JJ parallel) (PP (TO to) (NP (DT the) (NN membrane)))) (, ,) (SBAR (JJ such) (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NNS helices)) (SBAR (WHNP (WDT that)) (S (VP (VBP delineate) (NP (NP (DT the) (NN counterpart)) (PP (IN of) (NP (DT the) (NN MHC) (JJ peptide-binding) (NN groove)))))))) (VP (VBP make) (NP (NP (JJ extensive) (NNS contacts)) (PP (IN with) (NP (NP (NNS helices)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN dimerization) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS structures)) (PP (IN of) (NP (NN _PROT1_))) (ADVP (RB alone)) (VP (CC and) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_)))))) (VP (VBP differ) (PP (IN in) (NP (NP (PRP$ their) (NN domain) (NN arrangement)) (CC and) (NP (NN dimer) (NNS interfaces)))) (, ,) (S (VP (VBG providing) (NP (NP (DT a) (NN mechanism)) (PP (IN for) (NP (NP (JJ communicating) (NN binding) (NNS events)) (PP (IN between) (NP (NN _PROT_) (NNS chains))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS structures)) (PP (IN of) (NP (NN _PROT1_))) (ADVP (RB alone)) (VP (CC and) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_)))))) (VP (VBP differ) (PP (IN in) (NP (NP (PRP$ their) (NN domain) (NN arrangement)) (CC and) (NP (NN dimer) (NNS interfaces)))) (, ,) (S (VP (VBG providing) (NP (NP (DT a) (NN mechanism)) (PP (IN for) (NP (NP (JJ communicating) (NN binding) (NNS events)) (PP (IN between) (NP (NN _PROT2_) (NNS chains))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS structures)) (PP (IN of) (NP (NN _PROT_))) (ADVP (RB alone)) (VP (CC and) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT1_)))))) (VP (VBP differ) (PP (IN in) (NP (NP (PRP$ their) (NN domain) (NN arrangement)) (CC and) (NP (NN dimer) (NNS interfaces)))) (, ,) (S (VP (VBG providing) (NP (NP (DT a) (NN mechanism)) (PP (IN for) (NP (NP (JJ communicating) (NN binding) (NNS events)) (PP (IN between) (NP (NN _PROT2_) (NNS chains))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_AND_PROT2_) (NN complex)) (VP (VP (VBZ suggests) (NP (NP (DT a) (VBG binding) (NN site)) (PP (IN for) (NP (NN transferrin))) (PP (IN on) (NP (NN _PROT_))))) (CC and) (VP (VBZ sheds) (NP (NN light)) (PP (IN upon) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (S (VP (VBG regulating) (NP (NN iron) (NN homeostasis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (VP (VP (VBZ suggests) (NP (NP (DT a) (VBG binding) (NN site)) (PP (IN for) (NP (NN transferrin))) (PP (IN on) (NP (NN _PROT2_))))) (CC and) (VP (VBZ sheds) (NP (NN light)) (PP (IN upon) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (S (VP (VBG regulating) (NP (NN iron) (NN homeostasis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (VP (VP (VBZ suggests) (NP (NP (DT a) (VBG binding) (NN site)) (PP (IN for) (NP (NN transferrin))) (PP (IN on) (NP (NN _PROT_))))) (CC and) (VP (VBZ sheds) (NP (NN light)) (PP (IN upon) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (S (VP (VBG regulating) (NP (NN iron) (NN homeostasis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (VP (VP (VBZ suggests) (NP (NP (DT a) (VBG binding) (NN site)) (PP (IN for) (NP (NN transferrin))) (PP (IN on) (NP (NN _PROT2_))))) (CC and) (VP (VBZ sheds) (NP (NN light)) (PP (IN upon) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (S (VP (VBG regulating) (NP (NN iron) (NN homeostasis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (VP (VP (VBZ suggests) (NP (NP (DT a) (VBG binding) (NN site)) (PP (IN for) (NP (NN transferrin))) (PP (IN on) (NP (NN _PROT_))))) (CC and) (VP (VBZ sheds) (NP (NN light)) (PP (IN upon) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (S (VP (VBG regulating) (NP (NN iron) (NN homeostasis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN complex)) (VP (VP (VBZ suggests) (NP (NP (DT a) (VBG binding) (NN site)) (PP (IN for) (NP (NN transferrin))) (PP (IN on) (NP (NN _PROT1_))))) (CC and) (VP (VBZ sheds) (NP (NN light)) (PP (IN upon) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (S (VP (VBG regulating) (NP (NN iron) (NN homeostasis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NNP S252W) (NN mutation)) (VP (VBZ allows) (NP (NP (NP (DT the) (JJ mesenchymal) (NN splice) (NN form)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (TO to) (VP (VB bind))) (CC and) (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (DT the) (ADJP (RB mesenchymally) (VBN expressed)) (NNS ligands)) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))) (CC and) (NP (NP (NP (DT the) (JJ epithelial) (NN splice) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (S (VP (TO to) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBZ decreases) (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN at) (NP (NP (NNS sites)) (SBAR (WHNP (WDT that)) (S (ADVP (RB negatively)) (VP (VBP regulate) (NP (PRP$ its) (JJ DNA-binding) (NN activity))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (VBG resting) (JJ human) (ADJP (ADJP (JJ epithelial)) (CC and) (ADJP (JJ fibroblastic))) (NNS cells))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN on) (NP (NP (NN serine)) (CC and) (NP (NN threonine)))) (PP (IN at) (NP (NP (CD five) (NNS sites)) (, ,) (SBAR (WHNP (NP (CD three)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN phosphorylated) (ADVP (FW in) (FW vitro)) (PP (IN by) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (VBG resting) (JJ human) (ADJP (ADJP (JJ epithelial)) (CC and) (ADJP (JJ fibroblastic))) (NNS cells))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN on) (NP (NP (NN serine)) (CC and) (NP (NN threonine)))) (PP (IN at) (NP (NP (CD five) (NNS sites)) (, ,) (SBAR (WHNP (NP (CD three)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN phosphorylated) (ADVP (FW in) (FW vitro)) (PP (IN by) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (VBG resting) (JJ human) (ADJP (ADJP (JJ epithelial)) (CC and) (ADJP (JJ fibroblastic))) (NNS cells))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN on) (NP (NP (NN serine)) (CC and) (NP (NN threonine)))) (PP (IN at) (NP (NP (CD five) (NNS sites)) (, ,) (SBAR (WHNP (NP (CD three)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN phosphorylated) (ADVP (FW in) (FW vitro)) (PP (IN by) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VP (VBZ results) (PP (IN in) (NP (NP (ADJP (ADJP (JJ rapid)) (, ,) (ADJP (JJ site-specific))) (NN dephosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN at) (NP (NP (NP (CD one)) (CC or) (NP (JJR more))) (PP (IN of) (NP (DT these) (CD three) (NNS sites)))))))) (CC and) (VP (VBZ is) (ADJP (JJ coincident) (PP (IN with) (NP (VBN increased) (NN _PROT_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VP (VBZ results) (PP (IN in) (NP (NP (ADJP (ADJP (JJ rapid)) (, ,) (ADJP (JJ site-specific))) (NN dephosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN at) (NP (NP (NP (CD one)) (CC or) (NP (JJR more))) (PP (IN of) (NP (DT these) (CD three) (NNS sites)))))))) (CC and) (VP (VBZ is) (ADJP (JJ coincident) (PP (IN with) (NP (VBN increased) (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (VP (VP (VBZ results) (PP (IN in) (NP (NP (ADJP (ADJP (JJ rapid)) (, ,) (ADJP (JJ site-specific))) (NN dephosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN at) (NP (NP (NP (CD one)) (CC or) (NP (JJR more))) (PP (IN of) (NP (DT these) (CD three) (NNS sites)))))))) (CC and) (VP (VBZ is) (ADJP (JJ coincident) (PP (IN with) (NP (VBN increased) (NN _PROT2_) (NN activity))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Phosphorylation)) (PP (IN of) (NP (JJ recombinant) (JJ human) (NN _PROT1_) (NNS proteins))) (ADVP (FW in) (FW vitro)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ decreases) (NP (PRP$ their) (JJ DNA-binding) (NN activity)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ present) (PP (IN in) (NP (VBG resting) (NNS cells))) (PP (IN in) (NP (NP (DT a) (JJ latent) (, ,) (JJ phosphorylated) (NN form)) (SBAR (WHNP (WDT that)) (S (VP (MD can) (VP (VB be) (VP (VBN activated) (PP (IN by) (NP (JJ site-specific) (NN dephosphorylation))) (PP (IN in) (NN response) (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Two) (NN cDNA) (NNS clones)) (VP (VBG encoding) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (JJ human) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN isolated) (PP (IN by) (NP (NP (NN expression) (NN screening)) (PP (IN of) (NP (NP (DT a) (NN library)) (VP (VBN made) (PP (IN from) (NP (JJ human) (JJ placental) (NN mRNA))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VP (VBZ does) (RB not) (VP (VP (VB contain) (NP (DT a) (NN tyrosine) (NN kinase) (NN domain))) (CC nor) (VP (VB show) (NP (NP (NN homology)) (PP (IN with) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN immunoglobulin) (NN super) (NN gene) (NN family))))))))) (, ,) (CC but) (VP (VBZ does) (VP (VB show) (NP (NP (DT some) (JJ significant) (NN sequence) (NNS homologies)) (PP (IN with) (NP (NP (NNS receptors)) (PP (IN for) (NP (NP (JJ several) (JJ other) (JJ haemopoietic) (NN growth) (NNS factors)) (, ,) (PP (VBG including) (NP (NP (DT those)) (PP (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (-LRB- -LRB-) (NN beta-chain) (-RRB- -RRB-)))) (CC and) (ADVP (RB also)) (PP (TO to) (NP (DT the) (NN prolactin) (NN receptor))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VP (VBZ does) (RB not) (VP (VP (VB contain) (NP (DT a) (NN tyrosine) (NN kinase) (NN domain))) (CC nor) (VP (VB show) (NP (NP (NN homology)) (PP (IN with) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN immunoglobulin) (NN super) (NN gene) (NN family))))))))) (, ,) (CC but) (VP (VBZ does) (VP (VB show) (NP (NP (DT some) (JJ significant) (NN sequence) (NNS homologies)) (PP (IN with) (NP (NP (NNS receptors)) (PP (IN for) (NP (NP (JJ several) (JJ other) (JJ haemopoietic) (NN growth) (NNS factors)) (, ,) (PP (VBG including) (NP (NP (DT those)) (PP (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (-LRB- -LRB-) (NN beta-chain) (-RRB- -RRB-)))) (CC and) (ADVP (RB also)) (PP (TO to) (NP (DT the) (NN prolactin) (NN receptor))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VP (VBZ does) (RB not) (VP (VP (VB contain) (NP (DT a) (NN tyrosine) (NN kinase) (NN domain))) (CC nor) (VP (VB show) (NP (NP (NN homology)) (PP (IN with) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN immunoglobulin) (NN super) (NN gene) (NN family))))))))) (, ,) (CC but) (VP (VBZ does) (VP (VB show) (NP (NP (DT some) (JJ significant) (NN sequence) (NNS homologies)) (PP (IN with) (NP (NP (NNS receptors)) (PP (IN for) (NP (NP (JJ several) (JJ other) (JJ haemopoietic) (NN growth) (NNS factors)) (, ,) (PP (VBG including) (NP (NP (DT those)) (PP (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (-LRB- -LRB-) (NN beta-chain) (-RRB- -RRB-)))) (CC and) (ADVP (RB also)) (PP (TO to) (NP (DT the) (NN prolactin) (NN receptor))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN transfected) (PP (IN into) (NP (NN COS) (NNS cells)))))) (NP (DT the) (VBN cloned) (NN cDNA)) (VP (VBD directed) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN _PROT1_)) (VP (VBG showing) (NP (NP (DT a) (JJ single) (NN class)) (PP (IN of) (NP (NP (NP (NN affinity)) (PRN (-LRB- -LRB-) (NP (NP (NN KD)) (ADJP (JJ =) (NP (CD 2) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN nM)))) (-RRB- -RRB-))) (CC and) (NP (NP (NN specificity)) (PP (IN for) (NP (NP (JJ human) (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN transfected) (PP (IN into) (NP (NN COS) (NNS cells)))))) (NP (DT the) (VBN cloned) (NN cDNA)) (VP (VBD directed) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN _PROT1_)) (VP (VBG showing) (NP (NP (DT a) (JJ single) (NN class)) (PP (IN of) (NP (NP (NP (NN affinity)) (PRN (-LRB- -LRB-) (NP (NP (NN KD)) (ADJP (JJ =) (NP (CD 2) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN nM)))) (-RRB- -RRB-))) (CC and) (NP (NP (NN specificity)) (PP (IN for) (NP (NP (JJ human) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN transfected) (PP (IN into) (NP (NN COS) (NNS cells)))))) (NP (DT the) (VBN cloned) (NN cDNA)) (VP (VBD directed) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN _PROT_)) (VP (VBG showing) (NP (NP (DT a) (JJ single) (NN class)) (PP (IN of) (NP (NP (NP (NN affinity)) (PRN (-LRB- -LRB-) (NP (NP (NN KD)) (ADJP (JJ =) (NP (CD 2) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN nM)))) (-RRB- -RRB-))) (CC and) (NP (NP (NN specificity)) (PP (IN for) (NP (NP (JJ human) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)) (NP (NNS receptors))))) (VP (VBD analysed) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)) (NP (NNS receptors))))) (VP (VBD analysed) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)) (NP (NNS receptors))))) (VP (VBD analysed) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)) (NP (NNS receptors))))) (VP (VBD analysed) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)) (NP (NNS receptors))))) (VP (VBD analysed) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NNS receptors))))) (VP (VBD analysed) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))))) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN investigated) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)) (PP (IN by) (S (VP (VBG assessing) (PP (IN for) (NP (NP (NP (NP (NN his3)) (CC and) (NP (NN lacZ))) (NN activation)) (PP (IN in) (NP (FW S.) (FW cerevisiae))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS experiments)) (VP (VBD were) (VP (VBN performed) (PP (IN with) (NP (NP (NP (DT the) (JJ cytoplasmic) (NN beta) (NN domain)) (PRN (-LRB- -LRB-) (UCP (NP (JJ wild) (NN type)) (CC or) (ADJP (JJ mutated))) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (PRP$ its) (NNS subdomains))) (PRN (-LRB- -LRB-) (NP (NP (NP (NN N)) (CC +) (NP (NN C-SH2))) (, ,) (NP (NP (NN N-SH2)) (, ,) (NP (NN C-SH2)) (, ,) (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS experiments)) (VP (VBD were) (VP (VBN performed) (PP (IN with) (NP (NP (NP (DT the) (JJ cytoplasmic) (NN beta) (NN domain)) (PRN (-LRB- -LRB-) (UCP (NP (JJ wild) (NN type)) (CC or) (ADJP (JJ mutated))) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (CC and) (NP (NP (NP (NN _PROT2_)) (CC or) (NP (PRP$ its) (NNS subdomains))) (PRN (-LRB- -LRB-) (NP (NP (NP (NN N)) (CC +) (NP (NN C-SH2))) (, ,) (NP (NP (NN N-SH2)) (, ,) (NP (NN C-SH2)) (, ,) (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS experiments)) (VP (VBD were) (VP (VBN performed) (PP (IN with) (NP (NP (NP (DT the) (JJ cytoplasmic) (NN beta) (NN domain)) (PRN (-LRB- -LRB-) (UCP (NP (JJ wild) (NN type)) (CC or) (ADJP (JJ mutated))) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (CC and) (NP (NP (NP (NN _PROT2_)) (CC or) (NP (PRP$ its) (NNS subdomains))) (PRN (-LRB- -LRB-) (NP (NP (NP (NN N)) (CC +) (NP (NN C-SH2))) (, ,) (NP (NP (NN N-SH2)) (, ,) (NP (NN C-SH2)) (, ,) (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (NN his3) (NN activation)))) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN N)) (CC +) (NP (NN C-SH2))) (CC and) (NP (NN C-SH2))) (VP (VBP interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (IN whereas) (S (NP (NP (NN N-SH2)) (CC and) (NP (NP (NN SH3)) (CC +) (NP (NN N-SH2)))) (VP (VBP interact) (PP (ADVP (RB only)) (IN with) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN N+C-SH2)))) (PP (IN with) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NP (DT the) (JJ C-terminal) (CD 43) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (VP (VBG including) (NP (DT the) (NN YXXM) (NN motif))) (-RRB- -RRB-))) (VP (VBD were) (VP (VBN deleted))))))) (, ,)) (VP (VBD persisted))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ internal) (NN binding) (NN site)) (ADVP (RB thus)) (VP (VBD revealed) (VP (VBD was) (RB not) (VP (VBN altered) (PP (IN by) (S (ADVP (RB further)) (VP (VBG mutating) (NP (NP (NN Y960/F)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC or) (NP (NN Y950/F)))) (PP (IN for) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN lacZ))) (PP (IN upon) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN lacZ))) (PP (IN upon) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN lacZ))) (PP (IN upon) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN lacZ))) (PP (IN upon) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN lacZ))) (PP (IN upon) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN lacZ))) (PP (IN upon) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN activation)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))) (VP (VBD was) (ADJP (RB 4-fold) (JJR less)) (SBAR (IN as) (S (VP (VP (VBN compared) (PP (TO to) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (VP (VBD was) (ADVP (RB somewhat)) (VP (VBN increased) (PRN (-LRB- -LRB-) (ADVP (RB 2-fold)) (-RRB- -RRB-)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (JJ C-terminal) (NN domain)) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBZ appears) (S (VP (TO to) (VP (VB exert) (NP (NP (DT a) (JJ negative) (NN control)) (PP (IN on) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT2_)))))) (S (ADVP (RB thereby)) (VP (VBG providing) (NP (NP (DT a) (JJ possible) (JJ regulatory) (NN mechanism)) (PP (IN for) (NP (NP (JJ direct) (NN activation)) (PP (IN of) (NP (DT the) (NP (NN _PROT_) (NN _PROT_)) (NN pathway))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (JJ C-terminal) (NN domain)) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBZ appears) (S (VP (TO to) (VP (VB exert) (NP (NP (DT a) (JJ negative) (NN control)) (PP (IN on) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_)))))) (S (ADVP (RB thereby)) (VP (VBG providing) (NP (NP (DT a) (JJ possible) (JJ regulatory) (NN mechanism)) (PP (IN for) (NP (NP (JJ direct) (NN activation)) (PP (IN of) (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_)) (NN pathway))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (DT the) (JJ C-terminal) (NN domain)) (PP (IN in) (NP (NN _PROT_)))) (VP (VBZ appears) (S (VP (TO to) (VP (VB exert) (NP (NP (DT a) (JJ negative) (NN control)) (PP (IN on) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_)))))) (S (ADVP (RB thereby)) (VP (VBG providing) (NP (NP (DT a) (JJ possible) (JJ regulatory) (NN mechanism)) (PP (IN for) (NP (NP (JJ direct) (NN activation)) (PP (IN of) (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_)) (NN pathway))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ multisubunit) (NN protein) (NN complex)) (VP (VBN comprised) (PP (IN of) (NP (DT the) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ multiple) (JJ TBP-associated) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ multisubunit) (NN protein) (NN complex)) (VP (VBN comprised) (PP (IN of) (NP (DT the) (NP (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ multiple) (JJ TBP-associated) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ multisubunit) (NN protein) (NN complex)) (VP (VBN comprised) (PP (IN of) (NP (DT the) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ multiple) (JJ TBP-associated) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (DT a) (JJ complementary) (NN DNA)) (VP (VBG encoding) (NP (NP (DT a) (JJ human) (NN _PROT1_) (NN TAF)) (, ,) (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (NP (DT no) (JJ known) (NN homolog)) (PP (IN in) (NP (NN Drosophila) (NN _PROT_))))))))))) (VP (VBZ is) (ADVP (RB now)) (VP (VBN described)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (DT a) (JJ complementary) (NN DNA)) (VP (VBG encoding) (NP (NP (DT a) (JJ human) (NN _PROT1_) (NN TAF)) (, ,) (NP (NN _PROT_)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (NP (DT no) (JJ known) (NN homolog)) (PP (IN in) (NP (NN Drosophila) (NN _PROT2_))))))))))) (VP (VBZ is) (ADVP (RB now)) (VP (VBN described)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (DT a) (JJ complementary) (NN DNA)) (VP (VBG encoding) (NP (NP (DT a) (JJ human) (NN _PROT_) (NN TAF)) (, ,) (NP (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (NP (DT no) (JJ known) (NN homolog)) (PP (IN in) (NP (NN Drosophila) (NN _PROT2_))))))))))) (VP (VBZ is) (ADVP (RB now)) (VP (VBN described)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT2_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT2_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT1_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT1_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT1_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT1_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT1_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT1_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (JJ adenoviral) (NN _PROT2_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (JJ adenoviral) (NN _PROT_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (NP (DT the) (JJS largest) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (JJ human) (NN _PROT_))))) (PP (PP (IN through) (NP (PRP$ its) (JJ central) (NN region))) (CC and) (PP (IN with) (NP (NP (JJ multiple) (JJ activators--including) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (JJ adenoviral) (NN _PROT1_)) (, ,) (CC and) (NP (JJ human) (NN immunodeficiency) (JJ virus-type) (CD 1) (NN _PROT2_) (NN proteins--through)) (NP (DT a) (JJ distinct) (JJ amino-terminal) (NN domain))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT1_) (NN region)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD was) (VP (VBN localized) (PP (TO to) (NP (NP (PRP$ its) (JJ DNA-binding) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT the) (JJ glutamine-rich) (NN activation) (NNS domains)) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT1_) (NN region)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD was) (VP (VBN localized) (PP (TO to) (NP (NP (PRP$ its) (JJ DNA-binding) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT the) (JJ glutamine-rich) (NN activation) (NNS domains)) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN Drosophila) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT_) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD was) (VP (VBN localized) (PP (TO to) (NP (NP (PRP$ its) (JJ DNA-binding) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT the) (JJ glutamine-rich) (NN activation) (NNS domains)) (VP (ADVP (RB previously)) (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN Drosophila) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN exon)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD expressed) (NP (NP (NP (DT the) (NN cDNA)) (PP (IN of) (NP (JJ human) (NN _PROT1_) (NN _PROT1_)))) (CC and) (NP (NP (DT the) (NN COOH) (NN terminus)) (PP (IN of) (NP (NP (JJ human) (NN _PROT2_)) (PP (IN in) (NP (NN reticulocyte) (NNS lysates))))))) (S (VP (VBG using) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription/translation) (NN system)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT the) (CD 53) (NN amino) (NNS acids)) (VP (VBN encoded) (PP (IN on) (NP (NP (NP (NN exon) (CD 74)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN exon)) (, ,))))) (VP (VBP are) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (PRP$ our) (NN assay))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (JJ recombinant) (NN expression) (NN system))) (, ,) (NP (NP (DT the) (NN _PROT_) (NNS relatives)) (, ,) (NP (NP (NP (JJ human) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PP (IN from) (NP (JJ Torpedo) (JJ electric) (NN organ))))) (, ,)) (ADVP (RB also)) (VP (VBP bind) (PP (TO to) (NP (VBN translated) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN found) (NP (NP (DT a) (JJ COOH-terminal) (JJ 37-kD) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (VBN translated) (NN _PROT2_)) (CC and) (NP (PRP$ its) (NNS homologues)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (NN binding) (NN site)) (PP (IN on) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBZ occurs) (PP (IN on) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN among) (NP (DT the) (CD three) (NN syntrophin) (NNS homologues)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN found) (NP (NP (DT a) (JJ COOH-terminal) (JJ 37-kD) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (VBN translated) (NN _PROT_)) (CC and) (NP (PRP$ its) (NNS homologues)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_) (NN binding) (NN site)) (PP (IN on) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBZ occurs) (PP (IN on) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN among) (NP (DT the) (CD three) (NN syntrophin) (NNS homologues)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN found) (NP (NP (DT a) (JJ COOH-terminal) (JJ 37-kD) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (VBN translated) (NN _PROT_)) (CC and) (NP (PRP$ its) (NNS homologues)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (NN binding) (NN site)) (PP (IN on) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBZ occurs) (PP (IN on) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN among) (NP (DT the) (CD three) (NN syntrophin) (NNS homologues)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN found) (NP (NP (DT a) (JJ COOH-terminal) (JJ 37-kD) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (VBN translated) (NN _PROT1_)) (CC and) (NP (PRP$ its) (NNS homologues)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_) (NN binding) (NN site)) (PP (IN on) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBZ occurs) (PP (IN on) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN among) (NP (DT the) (CD three) (NN syntrophin) (NNS homologues)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN found) (NP (NP (DT a) (JJ COOH-terminal) (JJ 37-kD) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (VBN translated) (NN _PROT1_)) (CC and) (NP (PRP$ its) (NNS homologues)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (NN binding) (NN site)) (PP (IN on) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBZ occurs) (PP (IN on) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN among) (NP (DT the) (CD three) (NN syntrophin) (NNS homologues)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN found) (NP (NP (DT a) (JJ COOH-terminal) (JJ 37-kD) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (VBN translated) (NN _PROT_)) (CC and) (NP (PRP$ its) (NNS homologues)))))))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (NN binding) (NN site)) (PP (IN on) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBZ occurs) (PP (IN on) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN among) (NP (DT the) (CD three) (NN syntrophin) (NNS homologues)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activity)) (PP (IN of) (NP (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT1_)))) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT2_) (NN gene) (NN product))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein)) (VP (VBN encoded) (PP (IN by) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN tumour) (NN suppressor)) (CC and) (NP (JJ negative) (NN growth) (NN regulator)))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT2_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT2_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT2_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT2_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT1_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT2_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT1_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT1_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (EX there)) (VP (VBZ is) (NP (DT an) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN protein))) (PP (IN in) (NP (DT the) (ADJP (JJ nucleoli) (PP (IN of) (NP (NP (VBN differentiated) (NN U937) (NNS cells)) (SBAR (WHNP (WDT which)) (S (VP (VBZ correlates) (PP (IN with) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (NN rDNA) (NN transcription)) (: ;) (S (NP (NP (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription) (NN system)))) (VP (VBZ inhibits) (NP (NN transcription)) (PP (IN by) (NP (NN RNA) (NN polymerase) (CD I))))))))))))))))))) (: ;) (S (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT this) (NN inhibition)) (VP (VBZ requires) (NP (DT a) (JJ functional) (NN _PROT_) (NN pocket)))) (: ;) (CC and) (S (NP (LST (-LRB- -LRB-) (LS 4) (-RRB- -RRB-)) (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ inhibits) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (DT the) (NN RNA) (NN polymerase) (NN I) (NN transcription) (NN factor) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (FW vitro))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (JJ last) (NN observation)) (VP (VBD was) (VP (VBN confirmed) (PP (IN by) (NP (NP (NP (NN affinity) (NN chromatography)) (CC and) (NP (NN immunoprecipitation))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD demonstrated) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT an) (JJ additional) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN cell) (NN growth)) (, ,) (SBAR (RB namely) (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ represses) (NP (NP (NN transcription)) (PP (IN of) (NP (DT the) (NN rRNA) (NNS genes)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS rates)) (PP (IN of) (NP (NP (NN commitment)) (PP (TO to) (NP (NP (NN renaturation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (DT the) (NN groE) (NNS chaperonins))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN immunoprecipitation) (NNS techniques)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NNS rates)) (SBAR (WHPP (IN at) (WHNP (WDT which))) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (VP (VBN released) (PP (IN from) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN form)) (VP (VBN committed) (PP (TO to) (NP (NP (NN refold)) (PP (TO to) (NP (JJ active) (NN enzyme)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN immunoprecipitation) (NNS techniques)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NNS rates)) (SBAR (WHPP (IN at) (WHNP (WDT which))) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (VP (VBN released) (PP (IN from) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN form)) (VP (VBN committed) (PP (TO to) (NP (NP (NN refold)) (PP (TO to) (NP (JJ active) (NN enzyme)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN immunoprecipitation) (NNS techniques)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NNS rates)) (SBAR (WHPP (IN at) (WHNP (WDT which))) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (VP (VBN released) (PP (IN from) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN form)) (VP (VBN committed) (PP (TO to) (NP (NP (NN refold)) (PP (TO to) (NP (JJ active) (NN enzyme)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN immunoprecipitation) (NNS techniques)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NNS rates)) (SBAR (WHPP (IN at) (WHNP (WDT which))) (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (VP (VBN released) (PP (IN from) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN form)) (VP (VBN committed) (PP (TO to) (NP (NP (NN refold)) (PP (TO to) (NP (JJ active) (NN enzyme)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN immunoprecipitation) (NNS techniques)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NNS rates)) (SBAR (WHPP (IN at) (WHNP (WDT which))) (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (VP (VBN released) (PP (IN from) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN form)) (VP (VBN committed) (PP (TO to) (NP (NP (NN refold)) (PP (TO to) (NP (JJ active) (NN enzyme)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN immunoprecipitation) (NNS techniques)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NNS rates)) (SBAR (WHPP (IN at) (WHNP (WDT which))) (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (VP (VBP are) (VP (VBN released) (PP (IN from) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN form)) (VP (VBN committed) (PP (TO to) (NP (NP (NN refold)) (PP (TO to) (NP (JJ active) (NN enzyme)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (VP (VBD were) (VP (VBN chosen) (PP (IN as) (NP (NNS substrates))) (SBAR (IN because) (S (S (NP (PRP they)) (VP (VBP exhibit) (NP (NP (JJ different) (NN solution) (NNS requirements)) (PP (IN for) (NP (DT the) (NN chaperonin) (NN system)))))) (CC and) (S (NP (PRP they)) (VP (VBP form) (NP (NP (JJ stable) (`` ``) (ADJP (NN folding) (VBN arrested)) (NN '') (NNS complexes)) (PP (IN with) (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBD were) (VP (VBN chosen) (PP (IN as) (NP (NNS substrates))) (SBAR (IN because) (S (S (NP (PRP they)) (VP (VBP exhibit) (NP (NP (JJ different) (NN solution) (NNS requirements)) (PP (IN for) (NP (DT the) (NN chaperonin) (NN system)))))) (CC and) (S (NP (PRP they)) (VP (VBP form) (NP (NP (JJ stable) (`` ``) (ADJP (NN folding) (VBN arrested)) (NN '') (NNS complexes)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBD were) (VP (VBN chosen) (PP (IN as) (NP (NNS substrates))) (SBAR (IN because) (S (S (NP (PRP they)) (VP (VBP exhibit) (NP (NP (JJ different) (NN solution) (NNS requirements)) (PP (IN for) (NP (DT the) (NN chaperonin) (NN system)))))) (CC and) (S (NP (PRP they)) (VP (VBP form) (NP (NP (JJ stable) (`` ``) (ADJP (NN folding) (VBN arrested)) (NN '') (NNS complexes)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN At) (NP (CD 25) (NNS degrees) (NN C))) (, ,) (S (NP (DT the) (NN rate) (NNS profiles)) (VP (VBP indicate) (NP (DT the) (NN release)))) (CC and) (S (NP (NP (NN commitment)) (PP (TO to) (NP (NP (NN folding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (PRP$ its) (JJ native) (NN state)))))) (VP (VBZ occurs) (ADJP (ADJP (ADJP (ADJP (RB far) (JJR earlier)) (PRN (-LRB- -LRB-) (NP (NP (NN t1/2)) (ADJP (QP (RB <) (CD 1)) (NN min))) (-RRB- -RRB-))) (PP (IN than) (PP (IN for) (NP (NN _PROT2_))))) (PRN (-LRB- -LRB-) (NP (NP (NN t1/2)) (ADJP (JJ =) (NP (CD 5) (NN min)))) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN renaturation) (NN rate)) (PP (IN for) (NP (NN _PROT1_))) (PP (IN with) (NP (DT the) (NN groE) (NNS chaperonins)))) (VP (VBD mirrored) (NP (DT the) (VBN committed) (NN renaturation) (NNS rates)) (PP (VBG following) (NP (NN _PROT2_) (NN depletion))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD must) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (PP (IN throughout) (NP (NP (JJS most)) (PP (IN of) (NP (PRP$ its) (NN folding) (NN reaction)))))) (SBAR (IN before) (S (NP (PRP it)) (VP (VBZ acquires) (NP (DT a) (ADJP (ADJP (NN folding) (JJ competent)) (PRN (-LRB- -LRB-) (ADJP (NN groE) (JJ independent)) (-RRB- -RRB-))) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN If) (S (NP (NP (JJ current) (NNS models)) (PP (IN of) (NP (NN chaperonin) (NN mechanism)))) (VP (VBP are) (ADJP (JJ correct))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ undergoes) (NP (ADJP (ADJP (RBR more) (JJ rebinding)) (CC and) (ADJP (NN release))) (NNS cycles) (SBAR (IN than) (SINV (VBZ does) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cytokine)) (, ,) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (, ,)) (VP (VP (VBZ is) (VP (VBN produced) (PP (IN by) (NP (NP (DT a) (JJ wide) (NN variety)) (PP (IN of) (NP (NP (NNS cells)) (CC and) (NP (NNS tissues)))))))) (CC and) (VP (VBZ shares) (NP (JJ many) (JJ biological) (NNS properties)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cytokine)) (, ,) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (VP (VP (VBZ is) (VP (VBN produced) (PP (IN by) (NP (NP (DT a) (JJ wide) (NN variety)) (PP (IN of) (NP (NP (NNS cells)) (CC and) (NP (NNS tissues)))))))) (CC and) (VP (VBZ shares) (NP (JJ many) (JJ biological) (NNS properties)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cytokine)) (, ,) (VP (VBN designated) (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (, ,)) (VP (VP (VBZ is) (VP (VBN produced) (PP (IN by) (NP (NP (DT a) (JJ wide) (NN variety)) (PP (IN of) (NP (NP (NNS cells)) (CC and) (NP (NNS tissues)))))))) (CC and) (VP (VBZ shares) (NP (JJ many) (JJ biological) (NNS properties)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT2_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT2_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT1_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT1_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT1_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (JJ Monoclonal) (NNS antibodies)) (PP (TO to) (NP (NP (DT the) (NN beta) (NN chain)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN receptor)))))) (VP (VBD inhibited) (NP (NP (DT the) (JJ biological) (NN activity)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBD competed) (PP (IN for) (S (VP (VBG binding) (PP (IN with) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ uses) (NP (NP (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN zinc-finger) (NN transcription) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (ADJP (RB recently) (VBN cloned)) (NN _PROT1_)) (VP (VBZ is) (NP (PDT such) (DT an) (JJ _PROT2_) (NN _PROT2_)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB initiate) (NP (NN transcription)))))) (VP (VBZ is) (VP (VBN augmented) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NP (DT a) (NN TATA) (NN motif)) (CC or) (NP (NN binding) (NNS sites))) (PP (IN for) (NP (NN transcription) (NN factor) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NN mechanism)) (VP (VBG underlying) (NP (NP (DT the) (JJ apparent) (JJ functional) (NN cooperation)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (NP (PRP we)) (VP (VBD explored) (NP (NP (DT the) (NN possibility)) (PP (IN of) (NP (NP (JJ protein-protein) (NNS interactions)) (PP (IN between) (NP (DT these) (CD two) (NN transcription) (NNS factors)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB form) (NP (DT a) (JJ physical) (NN complex)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS domains)) (PP (IN within) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (NP (PRP$ their) (NNS interactions)) (PP (IN with) (NP (DT each) (JJ other)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (MD may) (ADVP (RB thus)) (VP (VB form) (NP (NP (DT the) (NN basis)) (PP (IN for) (NP (NP (DT the) (JJ functional) (NN interplay)) (VP (VBN observed) (ADVP (RB previously))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBG binding) (PP (TO to) (NP (NP (NP (JJ human) (NN _PROT2_)) (PP (IN on) (NP (NN T) (NNS cells)))) (CC and) (NP (NP (PRP$ its) (JJ biologic) (NN role)) (PP (IN in) (NP (JJ immune) (NN response)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN T) (NN cell) (NN activation) (NN Ag)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))))) (, ,)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN associated) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NP (NN T) (NNS cells)) (CC and) (NP (NN T) (NN cell) (NNS lines))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN T) (NN cell) (NN activation) (NN Ag)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_))))) (, ,)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN associated) (PP (IN with) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NP (NN T) (NNS cells)) (CC and) (NP (NN T) (NN cell) (NNS lines))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN T) (NN cell) (NN activation) (NN Ag)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_))))) (, ,)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN associated) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NP (NN T) (NNS cells)) (CC and) (NP (NN T) (NN cell) (NNS lines))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN T) (NN cell) (NN activation) (NN Ag)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))))) (, ,)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN associated) (PP (IN with) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NP (NN T) (NNS cells)) (CC and) (NP (NN T) (NN cell) (NNS lines))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN T) (NN cell) (NN activation) (NN Ag)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))))) (, ,)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN associated) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NP (NN T) (NNS cells)) (CC and) (NP (NN T) (NN cell) (NNS lines))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN T) (NN cell) (NN activation) (NN Ag)) (, ,) (VP (ADVP (RB also)) (VBN known) (PP (IN as) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_))))) (, ,)) (VP (VBZ is) (ADVP (RB directly)) (VP (VBN associated) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NP (NN T) (NNS cells)) (CC and) (NP (NN T) (NN cell) (NNS lines))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (CC both) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (CC and) (NP (NP (DT the) (JJ functional) (NNS consequences)) (PP (IN of) (NP (DT this) (NN interaction))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT2_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT1_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (NN _PROT_)) (PP (IN on) (NP (NP (NN T) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (JJ enzymatic) (NN activity)))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD did) (RB not) (VP (VB require) (NP (JJ enzymatic) (NN activity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (S (VP (VBG using) (NP (NN immunoelectron) (NN microscopy)))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD co-localized) (PP (IN on) (NP (NP (DT the) (NN cell) (NN surface)) (, ,) (CONJP (CC but) (RB not)) (NP (NN inside) (NNS cells)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD did) (RB not) (VP (VBP transport) (NP (NN _PROT_)) (PP (TO to) (NP (DT the) (NN surface)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (S (VP (VBG using) (NP (NN immunoelectron) (NN microscopy)))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD co-localized) (PP (IN on) (NP (NP (DT the) (NN cell) (NN surface)) (, ,) (CONJP (CC but) (RB not)) (NP (NN inside) (NNS cells)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBD did) (RB not) (VP (VBP transport) (NP (NN _PROT_)) (PP (TO to) (NP (DT the) (NN surface)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (S (VP (VBG using) (NP (NN immunoelectron) (NN microscopy)))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD co-localized) (PP (IN on) (NP (NP (DT the) (NN cell) (NN surface)) (, ,) (CONJP (CC but) (RB not)) (NP (NN inside) (NNS cells)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD did) (RB not) (VP (VBP transport) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (NN surface)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (S (VP (VBG using) (NP (NN immunoelectron) (NN microscopy)))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD co-localized) (PP (IN on) (NP (NP (DT the) (NN cell) (NN surface)) (, ,) (CONJP (CC but) (RB not)) (NP (NN inside) (NNS cells)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBD did) (RB not) (VP (VBP transport) (NP (NN _PROT_)) (PP (TO to) (NP (DT the) (NN surface)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (S (VP (VBG using) (NP (NN immunoelectron) (NN microscopy)))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD co-localized) (PP (IN on) (NP (NP (DT the) (NN cell) (NN surface)) (, ,) (CONJP (CC but) (RB not)) (NP (NN inside) (NNS cells)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD did) (RB not) (VP (VBP transport) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (NN surface)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (S (VP (VBG using) (NP (NN immunoelectron) (NN microscopy)))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD co-localized) (PP (IN on) (NP (NP (DT the) (NN cell) (NN surface)) (, ,) (CONJP (CC but) (RB not)) (NP (NN inside) (NNS cells)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD did) (RB not) (VP (VBP transport) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (NN surface)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (S (VP (VBG keeping) (PP (IN with) (NP (DT this) (NN observation)))))) (, ,) (NP (PRP we)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (JJ human) (JJ _PROT1_) (JJ murine) (NN pre-B) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (JJ human) (NN _PROT2_)))) (VP (VBD acquired) (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ extracellular) (NN source)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (S (VP (VBG keeping) (PP (IN with) (NP (DT this) (NN observation)))))) (, ,) (NP (PRP we)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (JJ human) (JJ _PROT1_) (JJ murine) (NN pre-B) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (JJ human) (NN _PROT_)))) (VP (VBD acquired) (NP (NN _PROT2_)) (PP (IN from) (NP (DT an) (JJ extracellular) (NN source)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (S (VP (VBG keeping) (PP (IN with) (NP (DT this) (NN observation)))))) (, ,) (NP (PRP we)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (JJ human) (JJ _PROT_) (JJ murine) (NN pre-B) (NN cell) (NNS lines)) (VP (VBG lacking) (NP (JJ human) (NN _PROT1_)))) (VP (VBD acquired) (NP (NN _PROT2_)) (PP (IN from) (NP (DT an) (JJ extracellular) (NN source)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RBR More) (RB importantly)) (, ,) (NP (NP (NN adenosine)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN cell) (NN surface) (NN _PROT1_)))))) (VP (VBD inhibited) (NP (NP (NP (NN T) (NN cell) (NN proliferation)) (CC and) (NP (NN _PROT2_) (NN production))) (VP (VBN induced) (PP (IN by) (NP (JJ various) (NNS stimuli))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN On) (NP (DT the) (JJ other) (NN hand))) (, ,) (NP (NP (NNS cells)) (VP (VBG expressing) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN on) (NP (DT the) (NN surface))))) (VP (VBD were) (ADJP (ADVP (RB much) (RBR more)) (JJ resistant) (PP (TO to) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (NN adenosine)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (PP (IN on) (NP (DT the) (NN cell) (NN surface)))) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT an) (ADJP (ADJP (JJ important)) (ADJP (JJ immunoregulatory))) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (VBN released) (NN _PROT2_)) (VP (VBZ binds) (PP (TO to) (NP (NN cell) (NN surface) (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (DT this) (NN complex)) (VP (VBZ is) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG reducing) (NP (NP (DT the) (JJ local) (NN concentration)) (PP (IN of) (NP (NN adenosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (PP (IN on) (NP (DT the) (NN cell) (NN surface)))) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT an) (ADJP (ADJP (JJ important)) (ADJP (JJ immunoregulatory))) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (VBN released) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NN cell) (NN surface) (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (DT this) (NN complex)) (VP (VBZ is) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG reducing) (NP (NP (DT the) (JJ local) (NN concentration)) (PP (IN of) (NP (NN adenosine)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (PP (IN on) (NP (DT the) (NN cell) (NN surface)))) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT an) (ADJP (ADJP (JJ important)) (ADJP (JJ immunoregulatory))) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (VBN released) (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NN cell) (NN surface) (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (DT this) (NN complex)) (VP (VBZ is) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG reducing) (NP (NP (DT the) (JJ local) (NN concentration)) (PP (IN of) (NP (NN adenosine)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ TNF-dependent) (NN recruitment)) (PP (IN of) (NP (DT the) (NN protein) (NN kinase) (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN signaling) (NN complex))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN death) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ triggers) (NP (NP (JJ distinct) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (NN activation)))))) (PP (IN through) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (DT the) (NN death) (NN domain) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN death) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ triggers) (NP (NP (JJ distinct) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)))))) (PP (IN through) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (DT the) (NN death) (NN domain) (NN protein) (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN death) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ triggers) (NP (NP (JJ distinct) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (NN activation)))))) (PP (IN through) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (DT the) (NN death) (NN domain) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN death) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ triggers) (NP (NP (JJ distinct) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)))))) (PP (IN through) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (DT the) (NN death) (NN domain) (NN protein) (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN death) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ triggers) (NP (NP (JJ distinct) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (NN activation)))))) (PP (IN through) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (DT the) (NN death) (NN domain) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN death) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ triggers) (NP (NP (JJ distinct) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (NN activation)))))) (PP (IN through) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (DT the) (NN death) (NN domain) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (ADVP (RB strongly)) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT another) (NN death) (NN domain) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN shown) (ADVP (RB previously)) (S (VP (TO to) (VP (VB associate) (PP (IN with) (NP (NN _PROT_) (NN antigen)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (ADVP (RB strongly)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT another) (NN death) (NN domain) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN shown) (ADVP (RB previously)) (S (VP (TO to) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_) (NN antigen)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ interacts) (ADVP (RB strongly)) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT another) (NN death) (NN domain) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN shown) (ADVP (RB previously)) (S (VP (TO to) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_) (NN antigen)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ serine-threonine) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN recruited) (PP (IN by) (NP (NN _PROT2_))) (PP (TO to) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ TNF-dependent) (NN process))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ serine-threonine) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN recruited) (PP (IN by) (NP (NN _PROT_))) (PP (TO to) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ TNF-dependent) (NN process))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ serine-threonine) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN recruited) (PP (IN by) (NP (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ TNF-dependent) (NN process))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (DT the) (JJ intact) (NN _PROT1_) (NN protein)))) (VP (VBZ induces) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (NP (DT the) (NN death) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VP (VBZ Induces) (NP (NN apoptosis))) (, ,) (CC but) (ADVP (RB potently)) (VP (VBZ inhibits) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)) (PP (IN by) (NP (NN TNF)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBP participate) (PP (IN in) (NP (NP (DT the) (NN TNF) (NN signaling) (NNS cascades)) (VP (VBG leading) (PP (TO to) (NP (NP (NN apoptosis)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (ADVP (RB physically)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT_))) (PP (IN via) (NP (PRP$ its) (NN DNA) (NN binding) (NN domain)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (ADVP (RB physically)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT2_))) (PP (IN via) (NP (PRP$ its) (NN DNA) (NN binding) (NN domain)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (ADVP (RB physically)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT2_))) (PP (IN via) (NP (PRP$ its) (NN DNA) (NN binding) (NN domain)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN As) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (DT this) (JJ physical) (NN interaction))))) (, ,) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))) (PP (TO to) (NP (NP (PRP$ its) (NN hormone) (NN response) (NNS elements)) (PP (CC either) (PP (IN as) (NP (NN homodimer))) (CC or) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))) (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ concentration-dependent) (NN manner)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN As) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (DT this) (JJ physical) (NN interaction))))) (, ,) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))) (PP (TO to) (NP (NP (PRP$ its) (NN hormone) (NN response) (NNS elements)) (PP (CC either) (PP (IN as) (NP (NN homodimer))) (CC or) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))) (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ concentration-dependent) (NN manner)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN As) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (DT this) (JJ physical) (NN interaction))))) (, ,) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_))) (PP (TO to) (NP (NP (PRP$ its) (NN hormone) (NN response) (NNS elements)) (PP (CC either) (PP (IN as) (NP (NN homodimer))) (CC or) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_))))))))) (VP (VBD was) (VP (VBN inhibited) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ concentration-dependent) (NN manner)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (JJ transfected) (NNS cells))) (, ,) (NP (JJ wild-type) (NN _PROT1_)) (VP (VBD repressed) (NP (NP (DT the) (JJ hormone-dependent) (JJ transcriptional) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ mutant) (NN _PROT1_)) (VP (CC either) (VP (VBD had) (NP (DT no) (NN effect))) (CC or) (VP (VBD activated) (NP (NP (DT the) (JJ transcriptional) (NN activity)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))) (PP (VBG depending) (PP (IN on) (NP (NP (DT the) (NN type)) (PP (IN of) (NP (NN hormone) (NN response) (NNS elements)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (VBN Enhanced) (NN degradation)) (PP (IN of) (NP (NN _PROT1_) (NNS receptors))) (PP (IN by) (NP (NP (DT a) (NN sorting) (NN _PROT2_)) (, ,) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (VBN Enhanced) (NN degradation)) (PP (IN of) (NP (NN _PROT1_) (NNS receptors))) (PP (IN by) (NP (NP (DT a) (NN sorting) (NN _PROT_)) (, ,) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (VBN Enhanced) (NN degradation)) (PP (IN of) (NP (NN _PROT_) (NNS receptors))) (PP (IN by) (NP (NP (DT a) (NN sorting) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NP (DT a) (JJ human) (NN cell) (NN line)) (SBAR (WHNP (WDT that)) (S (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (DT the) (JJ lysosomal) (NN targeting)) (VP (VBP code)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NP (DT a) (JJ human) (NN cell) (NN line)) (SBAR (WHNP (WDT that)) (S (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (DT the) (JJ lysosomal) (NN targeting)) (VP (VBP code)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NP (DT a) (JJ human) (NN cell) (NN line)) (SBAR (WHNP (WDT that)) (S (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (DT the) (JJ lysosomal) (NN targeting)) (VP (VBP code)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NP (DT a) (JJ human) (NN cell) (NN line)) (SBAR (WHNP (WDT that)) (S (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (DT the) (JJ lysosomal) (NN targeting)) (VP (VBP code)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NP (DT a) (JJ human) (NN cell) (NN line)) (SBAR (WHNP (WDT that)) (S (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (DT the) (JJ lysosomal) (NN targeting)) (VP (VBP code)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NP (DT a) (JJ human) (NN cell) (NN line)) (SBAR (WHNP (WDT that)) (S (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (DT the) (JJ lysosomal) (NN targeting)) (VP (VBP code)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NN homology)) (PP (TO to) (NP (DT a) (NN yeast) (NN vacuolar) (NN sorting) (NN protein)))))))) (, ,) (CC and) (S (NP (NP (NN overexpression)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD decreased) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (DT the) (NN cell) (NN surface)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (VBN enhanced) (NNS rates)) (PP (IN of) (NP (ADJP (ADJP (JJ constitutive)) (CC and) (ADJP (JJ ligand-induced))) (NN degradation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NN homology)) (PP (TO to) (NP (DT a) (NN yeast) (NN vacuolar) (NN sorting) (NN protein)))))))) (, ,) (CC and) (S (NP (NP (NN overexpression)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD decreased) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN on) (NP (DT the) (NN cell) (NN surface)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (VBN enhanced) (NNS rates)) (PP (IN of) (NP (ADJP (ADJP (JJ constitutive)) (CC and) (ADJP (JJ ligand-induced))) (NN degradation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ contains) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (NP (NN homology)) (PP (TO to) (NP (DT a) (NN yeast) (NN vacuolar) (NN sorting) (NN protein)))))))) (, ,) (CC and) (S (NP (NP (NN overexpression)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD decreased) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN on) (NP (DT the) (NN cell) (NN surface)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (VBN enhanced) (NNS rates)) (PP (IN of) (NP (ADJP (ADJP (JJ constitutive)) (CC and) (ADJP (JJ ligand-induced))) (NN degradation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ likely) (S (VP (TO to) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (NP (NP (NN sorting) (NN _PROT2_)) (PP (TO to) (NP (NNS lysosomes))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (NP (VBN selected) (JJ such) (NNS mutations)) (PP (IN in) (NP (NP (DT the) (NN transcription) (NN factor) (NN _PROT1_)) (SBAR (WHNP (WDT that)) (S (VP (VBP affect) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB heterodimerize) (PP (IN with) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (ADJP (ADJP (JJ Physical)) (CC and) (ADJP (JJ functional))) (NNS interactions)) (PP (IN between) (NP (NP (DT the) (JJ transcriptional) (NNS inhibitors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN Evidence))))) (PP (IN toward) (NP (NP (DT a) (JJ novel) (NN mechanism)) (VP (VBG regulating) (NP (JJ muscle-specific) (NN gene) (NN expression))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (DT an) (NN interaction) (NN cloning) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (DT an) (JJ inhibitory) (NN isoform)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT2_)) (, ,))) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ transcriptional) (NN inhibitor) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (DT an) (NN interaction) (NN cloning) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (DT an) (JJ inhibitory) (NN isoform)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT_)) (, ,))) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ transcriptional) (NN inhibitor) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (DT an) (NN interaction) (NN cloning) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (DT an) (JJ inhibitory) (NN isoform)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT_)) (, ,))) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ transcriptional) (NN inhibitor) (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (DT an) (NN interaction) (NN cloning) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (DT an) (JJ inhibitory) (NN isoform)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT1_)) (, ,))) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ transcriptional) (NN inhibitor) (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (DT an) (NN interaction) (NN cloning) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (DT an) (JJ inhibitory) (NN isoform)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT1_)) (, ,))) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ transcriptional) (NN inhibitor) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (DT an) (NN interaction) (NN cloning) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (DT an) (JJ inhibitory) (NN isoform)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT_)) (, ,))) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ transcriptional) (NN inhibitor) (NN _PROT1_AND_PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_AND_PROT2_)) (CC or) (NP (NN _PROT_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT_) (NN _PROT_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT_) (NN _PROT_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT2_) (NN _PROT2_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT_) (NN _PROT_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT_) (NN _PROT_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT2_) (NN _PROT2_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT_) (NN _PROT_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT2_) (NN _PROT2_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT_) (NN _PROT_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN expected)))) (, ,) (NP (NP (NN overexpression)) (PP (IN of) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))))) (ADVP (RB effectively)) (VP (VBD inhibited) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (JJ muscle-specific) (NN _PROT1_) (NN _PROT1_) (NN promoter))) (PP (IN by) (NP (DT the) (JJ myogenic) (NN transcription) (NN factor) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (SBAR (IN while) (S (NP (NN _PROT1_)) (VP (VBD inhibited) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN promoter))))) (, ,) (NP (PRP it)) (VP (VBD acted) (PP (IN as) (NP (NP (DT a) (JJ weak) (NN transactivator)) (PP (IN on) (NP (NP (DT an) (JJ artificial) (NN promoter)) (VP (VBG consisting) (PP (IN of) (NP (NP (CD three) (JJ tandem) (NNS copies)) (PP (IN of) (NP (DT the) (NN consensus) (JJ myogenic) (NN factor) (NN DNA) (NN binding) (NN site)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Further) (NN investigation)) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (DT the) (NN _PROT1_AND_PROT2_) (NN heterodimer)) (VP (VBD bound) (PP (TO to) (NP (PRP$ its) (JJ specific) (NN DNA) (NN binding) (NN site))) (ADVP (FW in) (FW vitro)))) (, ,) (CC and) (S (NP (DT the) (NN DNA) (NN binding)) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Further) (NN investigation)) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (DT the) (NN _PROT1_) (NN heterodimer)) (VP (VBD bound) (PP (TO to) (NP (PRP$ its) (JJ specific) (NN DNA) (NN binding) (NN site))) (ADVP (FW in) (FW vitro)))) (, ,) (CC and) (S (NP (DT the) (NN DNA) (NN binding)) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Further) (NN investigation)) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (DT the) (NN _PROT1_) (NN heterodimer)) (VP (VBD bound) (PP (TO to) (NP (PRP$ its) (JJ specific) (NN DNA) (NN binding) (NN site))) (ADVP (FW in) (FW vitro)))) (, ,) (CC and) (S (NP (DT the) (NN DNA) (NN binding)) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Further) (NN investigation)) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (DT the) (NN _PROT1_) (NN heterodimer)) (VP (VBD bound) (PP (TO to) (NP (PRP$ its) (JJ specific) (NN DNA) (NN binding) (NN site))) (ADVP (FW in) (FW vitro)))) (, ,) (CC and) (S (NP (DT the) (NN DNA) (NN binding)) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Further) (NN investigation)) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (DT the) (NN _PROT1_) (NN heterodimer)) (VP (VBD bound) (PP (TO to) (NP (PRP$ its) (JJ specific) (NN DNA) (NN binding) (NN site))) (ADVP (FW in) (FW vitro)))) (, ,) (CC and) (S (NP (DT the) (NN DNA) (NN binding)) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Further) (NN investigation)) (VP (VBD indicated) (SBAR (IN that) (S (S (NP (DT the) (NN _PROT_) (NN heterodimer)) (VP (VBD bound) (PP (TO to) (NP (PRP$ its) (JJ specific) (NN DNA) (NN binding) (NN site))) (ADVP (FW in) (FW vitro)))) (, ,) (CC and) (S (NP (DT the) (NN DNA) (NN binding)) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN blocked) (PP (IN by) (NP (NN _PROT1_AND_PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Additional) (NN analysis)) (VP (VBD revealed) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NNS transcripts)) (PP (IN for) (NP (CC both) (DT the) (ADJP (ADJP (JJ activating)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)) (CC and) (ADJP (JJ inhibitory)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS isoforms))))) (PP (IN in) (NP (VBG differentiating) (NN C2C12) (NNS cultures)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (DT both) (NNS isoforms)) (VP (MD might) (VP (VB participate) (PP (IN in) (S (VP (VBG regulating) (NP (DT the) (NN differentiation) (NN process))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Stimulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ results) (PP (IN in) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ functional) (NNS effects))) (, ,) (PP (VBG including) (NP (NP (NN regulation)) (PP (IN of) (NP (JJ epithelial) (NN cell) (NP (NP (NN growth)) (CC and) (NP (NN differentiation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB characterize) (NP (NP (DT the) (NN signaling) (NN pathway)) (SBAR (WHPP (IN through) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ regulates) (NP (NN cell) (NN growth)))))))))) (, ,) (NP (NP (NN L6) (NNS cells)) (VP (VBG lacking) (NP (DT any) (JJ endogenous) (NN FGFR)))) (VP (VBD were) (VP (ADVP (RB stably)) (VBN transfected) (PP (IN with) (NP (NP (NP (DT the) (CD two) (JJ different) (JJ human) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBP result) (PP (IN from) (NP (NP (JJ alternative) (NN splicing)) (PP (IN of) (NP (NP (NN exon) (CD III)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (VP (VBG encoding) (NP (DT the) (NN ligand) (NN binding) (NN domain))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT2_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT2_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT2_) (JJ _PROT2_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT2_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT2_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT2_) (JJ _PROT2_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT2_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT2_) (JJ _PROT2_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT1_) (JJ _PROT_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (ADJP (RB stably) (VBN transfected)) (NN L6) (NNS cells)))) (VP (VBD conferred) (NP (NN growth) (NNS responses)) (PP (TO to) (NP (NP (JJ several) (NNS members)) (PP (IN of) (NP (NP (DT the) (NN FGF) (NN family)) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (QP (CD -2) (, ,) (CD -4) (, ,) (CC and) (CD -6)))))))) (, ,) (SBAR (IN while) (S (NP (NN _PROT1_) (JJ _PROT1_) (NNS cells)) (VP (VBD responded) (ADVP (RB only)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN upon) (NP (NN ligand) (NN binding)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN activation)) (PP (IN of) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ utilizes) (NP (NP (CD two) (JJ different) (NNS pools)) (PP (IN of) (NP (NN adapter) (NN protein) (NN _PROT2_)))) (S (VP (TO to) (VP (VB link) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ utilizes) (NP (NP (CD two) (JJ different) (NNS pools)) (PP (IN of) (NP (NN adapter) (NN protein) (NN _PROT_)))) (S (VP (TO to) (VP (VB link) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ utilizes) (NP (NP (CD two) (JJ different) (NNS pools)) (PP (IN of) (NP (NN adapter) (NN protein) (NN _PROT1_)))) (S (VP (TO to) (VP (VB link) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (VBN Activated) (NN _PROT1_)) (ADVP (RB predominantly)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (PP (IN in) (NP (NN complex))) (PP (IN with) (NP (NP (DT a) (ADJP (RB previously) (VBN identified)) (JJ 90-kDa) (NN protein)) (CC and) (NP (VBN designated) (NN protein) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Tyrosine) (NN phophorylation)) (PP (IN of) (NP (DT the) (JJ 66-kDa) (NN protein)))) (VP (VBD was) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (DT the) (JJ 66-kDa) (NN protein)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (JJ _PROT2_) (NN signaling))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NN addition) (TO to) (NP (DT this) (JJ unique) (NN pathway))) (, ,) (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ links) (PP (TO to) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (JJ complex) (PP (IN via) (NP (DT the) (NN adapter) (NN protein) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (VBN activated) (NN _PROT1_)) (VP (VBD was) (RB not) (ADJP (JJ able) (S (VP (TO to) (VP (VB induce) (NP (NP (NN dissociation)) (PP (IN of) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (JJ complex) (NP (JJ following) (NN _PROT2_) (NN phosphorylation)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN summary))) (, ,) (NP (NN _PROT1_) (NN signaling) (NN pathway)) (VP (VBZ utilizes) (NP (CD two) (JJ _PROT2_) (NNS complexes))) (: ;) (NP (NN _PROT_))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN summary))) (, ,) (NP (NN _PROT1_) (NN signaling) (NN pathway)) (VP (VBZ utilizes) (NP (CD two) (JJ _PROT_) (NNS complexes))) (: ;) (NP (NN _PROT2_))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN summary))) (, ,) (NP (NN _PROT_) (NN signaling) (NN pathway)) (VP (VBZ utilizes) (NP (CD two) (JJ _PROT1_) (NNS complexes))) (: ;) (NP (NN _PROT2_))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: ;) (S (NP (DT these) (CD two) (NNS complexes)) (VP (MD may) (ADVP (RB alternatively)) (VP (VB link) (NP (NN _PROT2_)) (PP (TO to) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: ;) (S (NP (DT these) (CD two) (NNS complexes)) (VP (MD may) (ADVP (RB alternatively)) (VP (VB link) (NP (NN _PROT_)) (PP (TO to) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: ;) (S (NP (DT these) (CD two) (NNS complexes)) (VP (MD may) (ADVP (RB alternatively)) (VP (VB link) (NP (NN _PROT1_)) (PP (TO to) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (VBN activated) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB result) (PP (IN in) (NP (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (CC but) (NP (NP (VBN reduced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (VBN activated) (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB result) (PP (IN in) (NP (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (CC but) (NP (NP (VBN reduced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (VBN activated) (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB result) (PP (IN in) (NP (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (CC but) (NP (NP (VBN reduced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN cloning)) (PP (IN of) (NP (NP (NNS members)) (PP (IN of) (NP (DT these) (NN gene) (NNS families)))))) (CC and) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ protein-interaction) (NNS motifs)) (VP (VBN found) (PP (IN within) (NP (PRP$ their) (NN gene) (NNS products)))))))) (VP (VBZ has) (VP (VBN initiated) (NP (NP (DT the) (JJ molecular) (NN identity)) (PP (IN of) (NP (NP (NP (NNS factors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NNS TRAFs))) (-RRB- -RRB-))) (VP (VBN associated) (PP (PP (IN with) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS forms)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor))))))) (CC and) (PP (IN with) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN superfamily))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (NNS _PROT_) (NP (NN _PROT_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (NNS _PROT_) (NP (NN _PROT_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (NNS _PROT2_) (NP (NN _PROT_) (NN interaction)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (NNS _PROT2_) (NP (NN _PROT2_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (NNS _PROT_) (NP (NN _PROT_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (NNS _PROT2_) (NP (NN _PROT_) (NN interaction)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (NNS _PROT2_) (NP (NN _PROT2_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (NNS _PROT2_) (NP (NN _PROT_) (NN interaction)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (NNS _PROT2_) (NP (NN _PROT2_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (NNS _PROT1_AND_PROT2_) (NP (NN _PROT2_) (NN interaction)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ death-inducing) (NN receptor) (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (SBAR (WHADVP (WRB when)) (S (VP (VBN cross-linked) (PP (IN by) (NP (NP (DT the) (NN type) (CD II) (NN membrane) (NN protein) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ death-inducing) (NN receptor) (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (SBAR (WHADVP (WRB when)) (S (VP (VBN cross-linked) (PP (IN by) (NP (NP (DT the) (NN type) (CD II) (NN membrane) (NN protein) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ death-inducing) (NN receptor) (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (SBAR (WHADVP (WRB when)) (S (VP (VBN cross-linked) (PP (IN by) (NP (NP (DT the) (NN type) (CD II) (NN membrane) (NN protein) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ death-inducing) (NN receptor) (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (SBAR (WHADVP (WRB when)) (S (VP (VBN cross-linked) (PP (IN by) (NP (NP (DT the) (NN type) (CD II) (NN membrane) (NN protein) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ death-inducing) (NN receptor) (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (SBAR (WHADVP (WRB when)) (S (VP (VBN cross-linked) (PP (IN by) (NP (NP (DT the) (NN type) (CD II) (NN membrane) (NN protein) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ death-inducing) (NN receptor) (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (SBAR (WHADVP (WRB when)) (S (VP (VBN cross-linked) (PP (IN by) (NP (NP (DT the) (NN type) (CD II) (NN membrane) (NN protein) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (JJ human) (JJ soluble) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN sFasL)) (, ,) (VP (VBG containing) (NP (DT the) (JJ extracellular) (NN portion)))) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN expressed) (PP (IN in) (NP (JJ human) (NN embryo) (NN kidney) (CD 293) (NNS cells))))))) (, ,) (NP (NP (DT the) (CD three) (JJ N-linked) (NNS glycans)) (PP (IN of) (NP (DT each) (NN _PROT2_) (NN monomer)))) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ essential) (PP (IN for) (NP (JJ efficient) (NN secretion)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT the) (ADJP (RB closely) (JJ related)) (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN complex)))))) (, ,) (NP (NP (DT a) (JJ molecular) (NN model)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN homotrimer)) (VP (VBD bound) (PP (TO to) (NP (CD three) (NN _PROT_) (NNS molecules))))))) (VP (VBD was) (VP (VBN generated) (S (VP (VBG using) (NP (JJ knowledge-based) (NN protein) (NN modeling) (NNS methods)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT the) (ADJP (RB closely) (JJ related)) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN complex)))))) (, ,) (NP (NP (DT a) (JJ molecular) (NN model)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN homotrimer)) (VP (VBD bound) (PP (TO to) (NP (CD three) (NN _PROT_) (NNS molecules))))))) (VP (VBD was) (VP (VBN generated) (S (VP (VBG using) (NP (JJ knowledge-based) (NN protein) (NN modeling) (NNS methods)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT the) (ADJP (RB closely) (JJ related)) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN complex)))))) (, ,) (NP (NP (DT a) (JJ molecular) (NN model)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN homotrimer)) (VP (VBD bound) (PP (TO to) (NP (CD three) (NN _PROT2_) (NNS molecules))))))) (VP (VBD was) (VP (VBN generated) (S (VP (VBG using) (NP (JJ knowledge-based) (NN protein) (NN modeling) (NNS methods)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT the) (ADJP (RB closely) (JJ related)) (NN _PROT_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN complex)))))) (, ,) (NP (NP (DT a) (JJ molecular) (NN model)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN homotrimer)) (VP (VBD bound) (PP (TO to) (NP (CD three) (NN _PROT_) (NNS molecules))))))) (VP (VBD was) (VP (VBN generated) (S (VP (VBG using) (NP (JJ knowledge-based) (NN protein) (NN modeling) (NNS methods)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT the) (ADJP (RB closely) (JJ related)) (NN _PROT_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN complex)))))) (, ,) (NP (NP (DT a) (JJ molecular) (NN model)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN homotrimer)) (VP (VBD bound) (PP (TO to) (NP (CD three) (NN _PROT2_) (NNS molecules))))))) (VP (VBD was) (VP (VBN generated) (S (VP (VBG using) (NP (JJ knowledge-based) (NN protein) (NN modeling) (NNS methods)))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT the) (ADJP (RB closely) (JJ related)) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN complex)))))) (, ,) (NP (NP (DT a) (JJ molecular) (NN model)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN homotrimer)) (VP (VBD bound) (PP (TO to) (NP (CD three) (NN _PROT2_) (NNS molecules))))))) (VP (VBD was) (VP (VBN generated) (S (VP (VBG using) (NP (JJ knowledge-based) (NN protein) (NN modeling) (NNS methods)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Mutants)) (NP (NP (NNP P206R)) (, ,) (NP (NNP P206D)) (, ,) (CC and) (NP (NNP P206F)))) (VP (VBD displayed) (NP (NP (VBN reduced) (NN cytotoxicity)) (PP (IN toward) (NP (JJ _PROT1_) (NNS cells)))) (PP (IN with) (NP (NP (DT a) (JJ concomitant) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (IN for) (NP (DT the) (JJ recombinant) (NN _PROT2_) (NN Fc) (NN fusion) (NNS proteins))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (DT the) (JJ cytotoxic) (NN activity)) (PP (IN of) (NP (JJ mutant) (NN Y218D)))) (VP (VBD was) (ADJP (JJ unaltered))))) (, ,) (NP (JJ mutant) (NN Y218R)) (VP (VBD was) (ADJP (JJ inactive)) (, ,) (S (VP (VBG correlating) (PP (IN with) (NP (DT the) (NN prediction) (SBAR (IN that) (S (NP (NP (NN Tyr-218)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT a) (NN cluster)) (PP (IN of) (NP (NP (CD three) (JJ basic) (NN amino) (NN acid) (JJ side) (NNS chains)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Assaying) (UCP (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN complement) (NNS factors)))) (, ,) (CC and) (ADJP (JJ _PROT2_) (PP (IN in) (NP (NP (DT the) (NN diagnosis)) (PP (IN of) (NP (JJ malignant) (JJ serous) (NNS effusions))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN objective)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB measure) (NP (NP (DT the) (NNS concentrations)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (JJ pleural) (CC and) (JJ peritoneal) (NNS effusions)) (PP (IN of) (NP (JJ different) (NNS causes)))))))) (CC and) (VP (TO to) (VP (VB verify) (SBAR (IN whether) (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN complement) (NNS factors))) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (VP (VB be) (VP (VBN used) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NN effusion))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN complement) (NNS factors)) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS concentrations))) (VP (VBD were) (VP (VBN measured) (ADVP (RB simultaneously)) (PP (IN in) (NP (NP (NN blood)) (CC and) (NP (NN serous) (NN effusion)))) (S (VP (VBG using) (NP (ADJP (RB commercially) (JJ available)) (NNS methods))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN complement) (NNS factors)) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS concentrations))) (VP (VBD were) (VP (VBN measured) (ADVP (RB simultaneously)) (PP (IN in) (NP (NP (NN blood)) (CC and) (NP (NN serous) (NN effusion)))) (S (VP (VBG using) (NP (ADJP (RB commercially) (JJ available)) (NNS methods))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN complement) (NNS factors)) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS concentrations))) (VP (VBD were) (VP (VBN measured) (ADVP (RB simultaneously)) (PP (IN in) (NP (NP (NN blood)) (CC and) (NP (NN serous) (NN effusion)))) (S (VP (VBG using) (NP (ADJP (RB commercially) (JJ available)) (NNS methods))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN complement) (NNS factors)) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS concentrations))) (VP (VBD were) (VP (VBN measured) (ADVP (RB simultaneously)) (PP (IN in) (NP (NP (NN blood)) (CC and) (NP (NN serous) (NN effusion)))) (S (VP (VBG using) (NP (ADJP (RB commercially) (JJ available)) (NNS methods))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN complement) (NNS factors)) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS concentrations))) (VP (VBD were) (VP (VBN measured) (ADVP (RB simultaneously)) (PP (IN in) (NP (NP (NN blood)) (CC and) (NP (NN serous) (NN effusion)))) (S (VP (VBG using) (NP (ADJP (RB commercially) (JJ available)) (NNS methods))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN complement) (NNS factors)) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS concentrations))) (VP (VBD were) (VP (VBN measured) (ADVP (RB simultaneously)) (PP (IN in) (NP (NP (NN blood)) (CC and) (NP (NN serous) (NN effusion)))) (S (VP (VBG using) (NP (ADJP (RB commercially) (JJ available)) (NNS methods))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Their) (NN order)) (PP (IN of) (NP (NN selection)))) (VP (VBD was) (NP (NP (NN _PROT1_) (NN effusion)) (, ,) (NP (NN _PROT2_) (NN serum)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN effusion))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Their) (NN order)) (PP (IN of) (NP (NN selection)))) (VP (VBD was) (NP (NP (NN _PROT1_) (NN effusion)) (, ,) (NP (NN _PROT_) (NN serum)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN effusion))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Their) (NN order)) (PP (IN of) (NP (NN selection)))) (VP (VBD was) (NP (NP (NN _PROT1_) (NN effusion)) (, ,) (NP (NN _PROT_) (NN serum)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN effusion))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Their) (NN order)) (PP (IN of) (NP (NN selection)))) (VP (VBD was) (NP (NP (NN _PROT_) (NN effusion)) (, ,) (NP (NN _PROT1_) (NN serum)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN effusion))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Their) (NN order)) (PP (IN of) (NP (NN selection)))) (VP (VBD was) (NP (NP (NN _PROT_) (NN effusion)) (, ,) (NP (NN _PROT1_) (NN serum)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN effusion))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Their) (NN order)) (PP (IN of) (NP (NN selection)))) (VP (VBD was) (NP (NP (NN _PROT_) (NN effusion)) (, ,) (NP (NN _PROT_) (NN serum)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN effusion))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Determination)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN complement) (NNS factors)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (, ,) (CC and) (NP (NN _PROT_))))) (VP (MD may) (VP (VB be) (NP (DT a) (JJ significant) (NN parameter)) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NNS effusions))))) (, ,) (PP (ADVP (RB particularly)) (IN in) (NP (NP (DT those) (NNS patients)) (PP (IN with) (NP (JJ malignant) (NN disease)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Determination)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN complement) (NNS factors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (, ,) (CC and) (NP (NN _PROT_))))) (VP (MD may) (VP (VB be) (NP (DT a) (JJ significant) (NN parameter)) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NNS effusions))))) (, ,) (PP (ADVP (RB particularly)) (IN in) (NP (NP (DT those) (NNS patients)) (PP (IN with) (NP (JJ malignant) (NN disease)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Determination)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN complement) (NNS factors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (MD may) (VP (VB be) (NP (DT a) (JJ significant) (NN parameter)) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NNS effusions))))) (, ,) (PP (ADVP (RB particularly)) (IN in) (NP (NP (DT those) (NNS patients)) (PP (IN with) (NP (JJ malignant) (NN disease)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Determination)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN complement) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (, ,) (CC and) (NP (NN _PROT_))))) (VP (MD may) (VP (VB be) (NP (DT a) (JJ significant) (NN parameter)) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NNS effusions))))) (, ,) (PP (ADVP (RB particularly)) (IN in) (NP (NP (DT those) (NNS patients)) (PP (IN with) (NP (JJ malignant) (NN disease)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Determination)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN complement) (NNS factors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (MD may) (VP (VB be) (NP (DT a) (JJ significant) (NN parameter)) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NNS effusions))))) (, ,) (PP (ADVP (RB particularly)) (IN in) (NP (NP (DT those) (NNS patients)) (PP (IN with) (NP (JJ malignant) (NN disease)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Determination)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN complement) (NNS factors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (MD may) (VP (VB be) (NP (DT a) (JJ significant) (NN parameter)) (PP (IN in) (NP (NP (DT the) (JJ differential) (NN diagnosis)) (PP (IN of) (NP (JJ serous) (NNS effusions))))) (, ,) (PP (ADVP (RB particularly)) (IN in) (NP (NP (DT those) (NNS patients)) (PP (IN with) (NP (JJ malignant) (NN disease)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Most) (NP (JJ familial) (JJ early-onset) (NN Alzheimer) (POS 's) (NN disease)) (NNS cases)) (VP (VBP are) (VP (VBN caused) (PP (IN by) (NP (NP (NNS mutations)) (PP (IN in) (NP (DT the) (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN gene)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (JJ numerous) (NNS studies)) (VP (VBD revealed) (NP (NP (JJ predominant) (NN localization)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NP (JJ endoplasmic) (NN reticulum)) (CC and) (NP (NN Golgi)))))))) (, ,) (NP (EX there)) (VP (VBP are) (NP (NP (VBG conflicting) (NNS reports)) (PP (IN on) (NP (NP (DT the) (NN localization)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (DT the) (NN cell) (NN surface)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Cell) (NN surface) (NN _PROT1_)) (VP (VBD formed) (NP (NNS complexes)) (ADVP (FW in) (FW vivo)) (PP (IN with) (NP (NP (NP (JJ actin-binding) (NN protein) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD _PROT_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VP (VB form) (NP (NP (NNS bridges)) (PP (IN between) (NP (NP (NN cell) (NN surface) (NNS receptors)) (CC and) (NP (NN cytoskeleton)))))) (CC and) (VP (VB mediate) (NP (NP (NN cell) (NN adhesion)) (CC and) (NP (NN cell) (NN motility))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Cell) (NN surface) (NN _PROT1_)) (VP (VBD formed) (NP (NNS complexes)) (ADVP (FW in) (FW vivo)) (PP (IN with) (NP (NP (NP (JJ actin-binding) (NN protein) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD _PROT2_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VP (VB form) (NP (NP (NNS bridges)) (PP (IN between) (NP (NP (NN cell) (NN surface) (NNS receptors)) (CC and) (NP (NN cytoskeleton)))))) (CC and) (VP (VB mediate) (NP (NP (NN cell) (NN adhesion)) (CC and) (NP (NN cell) (NN motility))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Cell) (NN surface) (NN _PROT_)) (VP (VBD formed) (NP (NNS complexes)) (ADVP (FW in) (FW vivo)) (PP (IN with) (NP (NP (NP (JJ actin-binding) (NN protein) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD _PROT2_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VP (VB form) (NP (NP (NNS bridges)) (PP (IN between) (NP (NP (NN cell) (NN surface) (NNS receptors)) (CC and) (NP (NN cytoskeleton)))))) (CC and) (VP (VB mediate) (NP (NP (NN cell) (NN adhesion)) (CC and) (NP (NN cell) (NN motility))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Molecular) (NNS determinants)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (DT the) (JJ C-terminal) (NN domain)) (PP (IN of) (NP (NP (NP (NN Alzheimer) (POS 's)) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS alpha-helices)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT a) (JJ previous) (NN work))) (, ,) (NP (PRP we)) (VP (VP (VBN predicted)) (CC and) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (JJ 29-42-residue) (NN fragment)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ has) (NP (NP (ADJP (FW in) (FW vitro)) (NNS capacities)) (ADJP (JJ close) (PP (TO to) (NP (NP (DT those)) (PP (IN of) (NP (NP (DT the) (JJ tilted) (NN fragment)) (PP (IN of) (NP (JJ viral) (NN fusion) (NNS proteins))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN E3)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (MD can) (VP (VB decrease) (NP (NP (DT the) (JJ fusogenic) (NN activity)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN 29-42)) (-RRB- -RRB-))))) (PP (IN via) (NP (DT a) (JJ direct) (NN interaction))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN E3)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_)))) (VP (MD can) (VP (VB decrease) (NP (NP (DT the) (JJ fusogenic) (NN activity)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN 29-42)) (-RRB- -RRB-))))) (PP (IN via) (NP (DT a) (JJ direct) (NN interaction))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN E3)) (CONJP (CC but) (RB not)) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (MD can) (VP (VB decrease) (NP (NP (DT the) (JJ fusogenic) (NN activity)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN 29-42)) (-RRB- -RRB-))))) (PP (IN via) (NP (DT a) (JJ direct) (NN interaction))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (PRP we)) (VP (VBD suggested) (SBAR (IN that) (S (NP (DT this) (NN fragment)) (VP (VBZ is) (VP (VBN implicated) (PP (PP (IN in) (NP (NP (DT the) (NN neurotoxicity)) (PP (IN of) (NP (NN _PROT1_))))) (CC and) (PP (IN in) (NP (NP (DT the) (JJ protective) (NNS effects)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (NN Alzheimer) (POS 's) (NN disease)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (JJ simulated) (NP (NP (NNS interactions)) (PP (IN of) (NP (NP (DT all) (JJ amphipathic) (NNS helices)) (PP (IN of) (NP (NNS _PROT1_) (NP (NP (NN _PROT1_)) (CC and) (NP (NN A-I))))))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))) (NP (JJ fusogenic) (NNS fragments))))) (PP (IN by) (NP (JJ molecular) (NN modeling)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (CD _PROT1_)) (VP (VBZ suppresses) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_) (NNS homodimers)))) (PP (IN via) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (CD _PROT1_)) (VP (VBZ suppresses) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_) (NNS homodimers)))) (PP (IN via) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (CD _PROT1_)) (VP (VBZ suppresses) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_) (NNS homodimers)))) (PP (IN via) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (CD _PROT_)) (VP (VBZ suppresses) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT1_) (NNS homodimers)))) (PP (IN via) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (CD _PROT_)) (VP (VBZ suppresses) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT1_) (NNS homodimers)))) (PP (IN via) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (CD _PROT_)) (VP (VBZ suppresses) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_) (NNS homodimers)))) (PP (IN via) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT1_AND_PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT the) (JJ causative) (NN gene)) (PP (IN for) (NP (NP (NP (DT an) (JJ autosomal) (JJ dominant) (JJ familial) (NN Alzheimer) (POS 's) (NN disease)) (PRN (-LRB- -LRB-) (NP (NN AD)) (-RRB- -RRB-))) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 14))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (, ,) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (NN _PROT_)))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN candidate)) (S (VP (TO to) (VP (VB mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN cell))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (NN _PROT2_)))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN candidate)) (S (VP (TO to) (VP (VB mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN cell))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (NN _PROT_)))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN candidate)) (S (VP (TO to) (VP (VB mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN cell))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (NN _PROT2_)))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN candidate)) (S (VP (TO to) (VP (VB mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT the) (NN cell))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (NN _PROT_)))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN candidate)) (S (VP (TO to) (VP (VB mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN cell))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (NN _PROT1_)))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN candidate)) (S (VP (TO to) (VP (VB mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN cell))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD screened) (PP (IN for) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP bind) (PP (TO to) (NP (NN _PROT1_))) (PP (IN from) (NP (NP (DT a) (JJ human) (JJ embryonic) (NN brain) (NN cDNA) (NN library)) (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN method))))))))))) (CC and) (VP (VBD isolated) (NP (NP (CD one) (NN clone)) (VP (VBG encoding) (NP (DT the) (NN _PROT2_) (NN gene))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD screened) (PP (IN for) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP bind) (PP (TO to) (NP (NN _PROT1_))) (PP (IN from) (NP (NP (DT a) (JJ human) (JJ embryonic) (NN brain) (NN cDNA) (NN library)) (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN method))))))))))) (CC and) (VP (VBD isolated) (NP (NP (CD one) (NN clone)) (VP (VBG encoding) (NP (DT the) (NN _PROT2_) (NN gene))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD screened) (PP (IN for) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP bind) (PP (TO to) (NP (NN _PROT_))) (PP (IN from) (NP (NP (DT a) (JJ human) (JJ embryonic) (NN brain) (NN cDNA) (NN library)) (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN method))))))))))) (CC and) (VP (VBD isolated) (NP (NP (CD one) (NN clone)) (VP (VBG encoding) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN gene))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_))) (PP (TO to) (NP (JJ full-length) (NN _PROT_)))) (VP (VBD was) (VP (VBN confirmed) (ADVP (FW in) (FW vitro)) (PP (PP (IN by) (NP (JJ pull-down) (NN assay))) (, ,) (CC and) (ADVP (FW in) (FW vivo)) (PP (IN by) (NP (NP (NN immunoprecipitation) (NNS assays)) (PP (IN with) (NP (JJ human) (NNS samples))) (, ,) (PP (VBG including) (NP (NN AD) (NNS brains))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (JJ full-length) (NN _PROT2_)))) (VP (VBD was) (VP (VBN confirmed) (ADVP (FW in) (FW vitro)) (PP (PP (IN by) (NP (JJ pull-down) (NN assay))) (, ,) (CC and) (ADVP (FW in) (FW vivo)) (PP (IN by) (NP (NP (NN immunoprecipitation) (NNS assays)) (PP (IN with) (NP (JJ human) (NNS samples))) (, ,) (PP (VBG including) (NP (NN AD) (NNS brains))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (JJ full-length) (NN _PROT2_)))) (VP (VBD was) (VP (VBN confirmed) (ADVP (FW in) (FW vitro)) (PP (PP (IN by) (NP (JJ pull-down) (NN assay))) (, ,) (CC and) (ADVP (FW in) (FW vivo)) (PP (IN by) (NP (NP (NN immunoprecipitation) (NNS assays)) (PP (IN with) (NP (JJ human) (NNS samples))) (, ,) (PP (VBG including) (NP (NN AD) (NNS brains))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Immunoelectronmicroscopic) (NN analysis)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (VP (VBD colocalized) (PP (IN at) (NP (NP (DT the) (JJ endoplasmic) (NN reticulum)) (, ,) (CC and) (NP (DT the) (JJ nuclear) (NN matrix)))) (PP (IN in) (NP (JJ human) (NN brain) (NNS neurons))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Immunoelectronmicroscopic) (NN analysis)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (VP (VBD colocalized) (PP (IN at) (NP (NP (DT the) (JJ endoplasmic) (NN reticulum)) (, ,) (CC and) (NP (DT the) (JJ nuclear) (NN matrix)))) (PP (IN in) (NP (JJ human) (NN brain) (NNS neurons))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Immunoelectronmicroscopic) (NN analysis)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (VP (VBD colocalized) (PP (IN at) (NP (NP (DT the) (JJ endoplasmic) (NN reticulum)) (, ,) (CC and) (NP (DT the) (JJ nuclear) (NN matrix)))) (PP (IN in) (NP (JJ human) (NN brain) (NNS neurons))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT2_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT2_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_AND_PROT2_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT1_AND_PROT2_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT1_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT1_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT1_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT1_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Chloramphenicol) (NN acetyltransferase)) (NNS assays)) (PP (IN in) (NP (NN F9) (NNS cells)))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ suppresses) (NP (NN transactivation)) (PP (PP (IN by) (NP (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NN _PROT_) (NNS heterodimers)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (VBN reported) (NN function)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (PP (IN By) (S (VP (VBG monitoring) (NP (JJ fluorescent) (JJ recombinant) (NN protein))))) (CC and) (PP (IN by) (NP (NN gel) (NN mobility) (NN shift) (NNS assays)))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN shown) (S (VP (VP (TO to) (VP (VB accelerate) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN from) (NP (DT the) (NN cytoplasm))) (PP (TO to) (NP (DT the) (NN nucleus)))))) (CC and) (VP (TO to) (ADVP (RB thereby)) (VP (VB suppress) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN homodimer))) (PP (TO to) (NP (NP (ADJP (NP (NP (NN 12-O-tetradecanoylphorbol-13-) (NN acetate)) (PRN (-LRB- -LRB-) (NP (NN TPA)) (-RRB- -RRB-))) (JJ -responsive)) (NN element)) (PRN (-LRB- -LRB-) (NP (NN TRE)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (PP (IN By) (S (VP (VBG monitoring) (NP (JJ fluorescent) (JJ recombinant) (NN protein))))) (CC and) (PP (IN by) (NP (NN gel) (NN mobility) (NN shift) (NNS assays)))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN shown) (S (VP (VP (TO to) (VP (VB accelerate) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN from) (NP (DT the) (NN cytoplasm))) (PP (TO to) (NP (DT the) (NN nucleus)))))) (CC and) (VP (TO to) (ADVP (RB thereby)) (VP (VB suppress) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_) (NN homodimer))) (PP (TO to) (NP (NP (ADJP (NP (NP (NN 12-O-tetradecanoylphorbol-13-) (NN acetate)) (PRN (-LRB- -LRB-) (NP (NN TPA)) (-RRB- -RRB-))) (JJ -responsive)) (NN element)) (PRN (-LRB- -LRB-) (NP (NN TRE)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (PP (IN By) (S (VP (VBG monitoring) (NP (JJ fluorescent) (JJ recombinant) (NN protein))))) (CC and) (PP (IN by) (NP (NN gel) (NN mobility) (NN shift) (NNS assays)))) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN shown) (S (VP (VP (TO to) (VP (VB accelerate) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN from) (NP (DT the) (NN cytoplasm))) (PP (TO to) (NP (DT the) (NN nucleus)))))) (CC and) (VP (TO to) (ADVP (RB thereby)) (VP (VB suppress) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_) (NN homodimer))) (PP (TO to) (NP (NP (ADJP (NP (NP (NN 12-O-tetradecanoylphorbol-13-) (NN acetate)) (PRN (-LRB- -LRB-) (NP (NN TPA)) (-RRB- -RRB-))) (JJ -responsive)) (NN element)) (PRN (-LRB- -LRB-) (NP (NN TRE)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD suppressed) (NP (JJ _PROT2_) (NN apoptosis)) (PP (IN by) (NP (NP (JJ retinoic) (NN acid)) (PP (IN in) (NP (NN F9) (JJ embryonic) (NN carcinoma) (NNS cells))))) (, ,) (SBAR (IN whereas) (S (NP (NP (DT this) (NN suppression)) (PP (IN of) (NP (NN apoptosis)))) (VP (VBZ is) (VP (VBN attenuated) (PP (IN by) (NP (NP (NN mutation)) (PP (IN in) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD suppressed) (NP (JJ _PROT_) (NN apoptosis)) (PP (IN by) (NP (NP (JJ retinoic) (NN acid)) (PP (IN in) (NP (NN F9) (JJ embryonic) (NN carcinoma) (NNS cells))))) (, ,) (SBAR (IN whereas) (S (NP (NP (DT this) (NN suppression)) (PP (IN of) (NP (NN apoptosis)))) (VP (VBZ is) (VP (VBN attenuated) (PP (IN by) (NP (NP (NN mutation)) (PP (IN in) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD suppressed) (NP (JJ _PROT1_) (NN apoptosis)) (PP (IN by) (NP (NP (JJ retinoic) (NN acid)) (PP (IN in) (NP (NN F9) (JJ embryonic) (NN carcinoma) (NNS cells))))) (, ,) (SBAR (IN whereas) (S (NP (NP (DT this) (NN suppression)) (PP (IN of) (NP (NN apoptosis)))) (VP (VBZ is) (VP (VBN attenuated) (PP (IN by) (NP (NP (NN mutation)) (PP (IN in) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NP (DT the) (JJ novel) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN via) (NP (NN _PROT2_)))) (VP (VBZ influences) (NP (NP (JJ _PROT_) (NN transcription)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NP (DT the) (JJ novel) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN via) (NP (NN _PROT2_)))) (VP (VBZ influences) (NP (NP (JJ _PROT_) (NN transcription)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NP (DT the) (JJ novel) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN via) (NP (NN _PROT_)))) (VP (VBZ influences) (NP (NP (JJ _PROT2_) (NN transcription)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NP (DT the) (JJ novel) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN via) (NP (NN _PROT1_AND_PROT2_)))) (VP (VBZ influences) (NP (NP (JJ _PROT_) (NN transcription)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NP (DT the) (JJ novel) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN via) (NP (NN _PROT1_)))) (VP (VBZ influences) (NP (NP (JJ _PROT2_) (NN transcription)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NP (DT the) (JJ novel) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN via) (NP (NN _PROT1_)))) (VP (VBZ influences) (NP (NP (JJ _PROT2_) (NN transcription)) (CC and) (NP (NN apoptosis))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN BMP) (NNS receptors)) (VP (VBP belong) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (NP (NN serine/threonine) (NN kinase) (NNS receptors)) (, ,) (SBAR (WHNP (WP$ whose) (NN activation)) (S (VP (VBZ has) (VP (VBN been) (VP (VBN investigated) (ADVP (RB intensively)) (PP (IN for) (NP (DT the) (NP (NP (VBG _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN receptor) (NN subfamily)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (JJ several) (JJ complementary) (NNS approaches)))) (, ,) (S (NP (PRP we)) (VP (VBD investigated) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (ADJP (ADJP (JJ homomeric)) (CC and) (ADJP (JJ heteromeric))) (NNS complexes))) (PP (IN between) (NP (NP (NP (DT the) (CD two) (JJ known) (NN BMP) (NN type) (NN I) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (JJ several) (JJ complementary) (NNS approaches)))) (, ,) (S (NP (PRP we)) (VP (VBD investigated) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (ADJP (ADJP (JJ homomeric)) (CC and) (ADJP (JJ heteromeric))) (NNS complexes))) (PP (IN between) (NP (NP (NP (DT the) (CD two) (JJ known) (NN BMP) (NN type) (NN I) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (JJ several) (JJ complementary) (NNS approaches)))) (, ,) (S (NP (PRP we)) (VP (VBD investigated) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (ADJP (ADJP (JJ homomeric)) (CC and) (ADJP (JJ heteromeric))) (NNS complexes))) (PP (IN between) (NP (NP (NP (DT the) (CD two) (JJ known) (NN BMP) (NN type) (NN I) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (JJ several) (JJ complementary) (NNS approaches)))) (, ,) (S (NP (PRP we)) (VP (VBD investigated) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (ADJP (ADJP (JJ homomeric)) (CC and) (ADJP (JJ heteromeric))) (NNS complexes))) (PP (IN between) (NP (NP (NP (DT the) (CD two) (JJ known) (NN BMP) (NN type) (NN I) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (JJ several) (JJ complementary) (NNS approaches)))) (, ,) (S (NP (PRP we)) (VP (VBD investigated) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (ADJP (ADJP (JJ homomeric)) (CC and) (ADJP (JJ heteromeric))) (NNS complexes))) (PP (IN between) (NP (NP (NP (DT the) (CD two) (JJ known) (NN BMP) (NN type) (NN I) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (JJ several) (JJ complementary) (NNS approaches)))) (, ,) (S (NP (PRP we)) (VP (VBD investigated) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (ADJP (ADJP (JJ homomeric)) (CC and) (ADJP (JJ heteromeric))) (NNS complexes))) (PP (IN between) (NP (NP (NP (DT the) (CD two) (JJ known) (NN BMP) (NN type) (NN I) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_AND_PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT2_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT2_) (NN _PROT_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ antibody-mediated) (NN immunofluorescence) (NN copatching)) (PP (IN of) (NP (JJ epitope-tagged) (NNS receptors)))))) (, ,) (NP (PRP we)) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN in) (NP (JJ live) (NNS cells))) (PP (IN for) (S (VP (VBG preexisting) (NP (ADJP (ADJP (JJ heteromeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)) (CC and) (ADJP (JJ homomeric)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (ADVP (RB also)) (NP (NN _PROT1_) (NN _PROT2_))) (-RRB- -RRB-))) (NNS oligomers)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN ligand)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN binding)) (ADVP (RB significantly)) (VP (VBD increased) (NP (NP (NN hetero-)) (CC and) (NP (NN homo-oligomerization))) (-LRB- -LRB-) (PP (IN except) (PP (IN for) (NP (NP (DT the) (NN _PROT2_) (NN homo-oligomer)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NN ligand)) (ADVP (RB poorly)) (PP (IN in) (DT the) (NN absence) (IN of) (NP (NN _PROT_))))))))) (-RRB- -RRB-))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN binding)) (ADVP (RB significantly)) (VP (VBD increased) (NP (NP (NN hetero-)) (CC and) (NP (NN homo-oligomerization))) (-LRB- -LRB-) (PP (IN except) (PP (IN for) (NP (NP (DT the) (NN _PROT_) (NN homo-oligomer)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NN ligand)) (ADVP (RB poorly)) (PP (IN in) (DT the) (NN absence) (IN of) (NP (NN _PROT2_))))))))) (-RRB- -RRB-))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_) (NN binding)) (ADVP (RB significantly)) (VP (VBD increased) (NP (NP (NN hetero-)) (CC and) (NP (NN homo-oligomerization))) (-LRB- -LRB-) (PP (IN except) (PP (IN for) (NP (NP (DT the) (NN _PROT1_) (NN homo-oligomer)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (NP (NN ligand)) (ADVP (RB poorly)) (PP (IN in) (DT the) (NN absence) (IN of) (NP (NN _PROT2_))))))))) (-RRB- -RRB-))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (NP (NN chemotaxis)) (CC and) (NP (NN adhesion))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (NP (NN chemotaxis)) (CC and) (NP (NN adhesion))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ induces) (NP (NP (NN chemotaxis)) (CC and) (NP (NN adhesion))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (ADJP (RB unusually) (JJ large)) (NN CC) (NN chemokine)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (VP (VBN known) (PP (IN as) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (NN chemotaxis)) (CC and) (NP (NP (JJ competitive) (NN binding) (NNS studies)) (SBAR (WHNP (WDT that)) (S (VP (VBP show) (NP (NNS _PROT1_)) (VP (VP (VBZ binds) (PP (TO to))) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (JJ transfected) (NN HEK-293) (NNS cells))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (NN chemotaxis)) (CC and) (NP (NP (JJ competitive) (NN binding) (NNS studies)) (SBAR (WHNP (WDT that)) (S (VP (VBP show) (NP (NNS _PROT1_)) (VP (VP (VBZ binds) (PP (TO to))) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (JJ transfected) (NN HEK-293) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (NN chemotaxis)) (CC and) (NP (NP (JJ competitive) (NN binding) (NNS studies)) (SBAR (WHNP (WDT that)) (S (VP (VBP show) (NP (NNS _PROT_)) (VP (VP (VBZ binds) (PP (TO to))) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (JJ transfected) (NN HEK-293) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (NP (JJ maximal) (NN migration)) (PP (IN of) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VBN transfected) (NNS cells))) (PP (IN at) (NP (CD 89.3) (NN nmol/L)))) (CC and) (NP (NN cell) (NN adhesion))) (PP (IN at) (NP (CD 5.6) (NN nmol/L))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (NP (JJ maximal) (NN migration)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VBN transfected) (NNS cells))) (PP (IN at) (NP (CD 89.3) (NN nmol/L)))) (CC and) (NP (NN cell) (NN adhesion))) (PP (IN at) (NP (CD 5.6) (NN nmol/L))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD induced) (NP (NP (NP (JJ maximal) (NN migration)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VBN transfected) (NNS cells))) (PP (IN at) (NP (CD 89.3) (NN nmol/L)))) (CC and) (NP (NN cell) (NN adhesion))) (PP (IN at) (NP (CD 5.6) (NN nmol/L))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN concentration)) (PP (IN of) (NP (NNS _PROT1_))) (VP (VBN required) (S (VP (TO to) (VP (VB induce) (NP (NN maximum) (NN cell) (NN migration))))))) (VP (VBZ is) (ADJP (NP (CD 20-) (TO to) (RB 200-fold)) (JJR greater) (PP (IN than) (NP (NP (DT that)) (VP (VBN required) (PP (IN for) (NP (NP (NN _PROT2_)) (CC or) (NP (NNP _PROT_)) (, ,) (ADVP (RB respectively)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN concentration)) (PP (IN of) (NP (NNS _PROT1_))) (VP (VBN required) (S (VP (TO to) (VP (VB induce) (NP (NN maximum) (NN cell) (NN migration))))))) (VP (VBZ is) (ADJP (NP (CD 20-) (TO to) (RB 200-fold)) (JJR greater) (PP (IN than) (NP (NP (DT that)) (VP (VBN required) (PP (IN for) (NP (NP (NN _PROT_)) (CC or) (NP (NNP _PROT2_)) (, ,) (ADVP (RB respectively)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN concentration)) (PP (IN of) (NP (NNS _PROT_))) (VP (VBN required) (S (VP (TO to) (VP (VB induce) (NP (NN maximum) (NN cell) (NN migration))))))) (VP (VBZ is) (ADJP (NP (CD 20-) (TO to) (RB 200-fold)) (JJR greater) (PP (IN than) (NP (NP (DT that)) (VP (VBN required) (PP (IN for) (NP (NP (NN _PROT1_)) (CC or) (NP (NNP _PROT2_)) (, ,) (ADVP (RB respectively)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (VBG neutralizing) (JJ polyclonal) (NN antibody)) (PP (TO to) (NP (NNS _PROT1_)))) (VP (VBD was) (VP (VBN developed) (S (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP (NP (DT the) (ADJP (RB unusually) (JJ high)) (NN concentration)) (PP (IN of) (NP (NNS _PROT2_))) (VP (VBN required) (S (VP (TO to) (VP (VB induce) (NP (NN chemotaxis))))))) (VP (VP (VBD was) (NP (NP (DT a) (NN property)) (PP (IN of) (NP (NNS _PROT_))))) (CC and) (VP (ADVP (RB not)) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (DT an) (JJ irrelevant) (NN protein) (NN contamination))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (VBG neutralizing) (JJ polyclonal) (NN antibody)) (PP (TO to) (NP (NNS _PROT1_)))) (VP (VBD was) (VP (VBN developed) (S (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP (NP (DT the) (ADJP (RB unusually) (JJ high)) (NN concentration)) (PP (IN of) (NP (NNS _PROT_))) (VP (VBN required) (S (VP (TO to) (VP (VB induce) (NP (NN chemotaxis))))))) (VP (VP (VBD was) (NP (NP (DT a) (NN property)) (PP (IN of) (NP (NNS _PROT2_))))) (CC and) (VP (ADVP (RB not)) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (DT an) (JJ irrelevant) (NN protein) (NN contamination))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (VBG neutralizing) (JJ polyclonal) (NN antibody)) (PP (TO to) (NP (NNS _PROT_)))) (VP (VBD was) (VP (VBN developed) (S (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP (NP (DT the) (ADJP (RB unusually) (JJ high)) (NN concentration)) (PP (IN of) (NP (NNS _PROT1_))) (VP (VBN required) (S (VP (TO to) (VP (VB induce) (NP (NN chemotaxis))))))) (VP (VP (VBD was) (NP (NP (DT a) (NN property)) (PP (IN of) (NP (NNS _PROT2_))))) (CC and) (VP (ADVP (RB not)) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (DT an) (JJ irrelevant) (NN protein) (NN contamination))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ recognizes) (NP (NP (CD one) (NN FGFR) (NN isoform)) (VP (VBN known) (PP (IN as) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN isoform)) (CC or) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (, ,) (IN whereas) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB well)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_))))) (CC but) (VP (VBZ interacts) (ADVP (RB poorly)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT this) (JJ primary) (NN site)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT a) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ restricts) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS sequences)) (SBAR (WHNP (WDT that)) (S (VP (VBP confer) (PP (IN on) (NP (NN _PROT1_))) (NP (NP (PRP$ its) (JJ specific) (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))) (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN identified))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN By) (S (VP (VBG utilizing) (NP (NP (NN domain) (NN swapping)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))) (NP (PRP we)) (VP (VBP have) (VP (VBN found) (SBAR (IN that) (S (NP (NP (DT the) (NN loop)) (VP (VBG connecting) (NP (NP (DT the) (NN beta4-beta5) (NNS strands)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VP (VBZ contributes) (PP (TO to) (NP (JJ high) (NN affinity) (NN receptor) (NN binding)))) (CC and) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NN _PROT2_) (NN recognition))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (DT this) (NN loop))) (PP (IN with) (NP (NP (DT the) (JJ homologous) (NN loop)) (PP (IN from) (NP (NN _PROT1_)))))) (ADVP (RB dramatically)) (VP (VP (VBD reduced) (NP (CC both) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (PRP$ its) (JJ biological) (NN potency)))) (CC but) (VP (VBD did) (RB not) (VP (VB result) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (DT this) (NN loop))) (PP (IN with) (NP (NP (DT the) (JJ homologous) (NN loop)) (PP (IN from) (NP (NN _PROT1_)))))) (ADVP (RB dramatically)) (VP (VP (VBD reduced) (NP (CC both) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (PRP$ its) (JJ biological) (NN potency)))) (CC but) (VP (VBD did) (RB not) (VP (VB result) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (DT this) (NN loop))) (PP (IN with) (NP (NP (DT the) (JJ homologous) (NN loop)) (PP (IN from) (NP (NN _PROT1_)))))) (ADVP (RB dramatically)) (VP (VP (VBD reduced) (NP (CC both) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (PRP$ its) (JJ biological) (NN potency)))) (CC but) (VP (VBD did) (RB not) (VP (VB result) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (DT this) (NN loop))) (PP (IN with) (NP (NP (DT the) (JJ homologous) (NN loop)) (PP (IN from) (NP (NN _PROT_)))))) (ADVP (RB dramatically)) (VP (VP (VBD reduced) (NP (CC both) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (PRP$ its) (JJ biological) (NN potency)))) (CC but) (VP (VBD did) (RB not) (VP (VB result) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (DT this) (NN loop))) (PP (IN with) (NP (NP (DT the) (JJ homologous) (NN loop)) (PP (IN from) (NP (NN _PROT_)))))) (ADVP (RB dramatically)) (VP (VP (VBD reduced) (NP (CC both) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (PRP$ its) (JJ biological) (NN potency)))) (CC but) (VP (VBD did) (RB not) (VP (VB result) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (DT this) (NN loop))) (PP (IN with) (NP (NP (DT the) (JJ homologous) (NN loop)) (PP (IN from) (NP (NN _PROT_)))))) (ADVP (RB dramatically)) (VP (VP (VBD reduced) (NP (CC both) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (PRP$ its) (JJ biological) (NN potency)))) (CC but) (VP (VBD did) (RB not) (VP (VB result) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ reciprocal) (NN loop) (NN replacement) (NN mutant)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD retained) (NP (NN _PROT2_)) (PP (IN like) (NP (NP (NN affinity)) (PP (PP (IN for) (NP (NN _PROT_))) (CC and) (PP (IN for) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ reciprocal) (NN loop) (NN replacement) (NN mutant)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD retained) (NP (NN _PROT_)) (PP (IN like) (NP (NP (NN affinity)) (PP (PP (IN for) (NP (NN _PROT2_))) (CC and) (PP (IN for) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ reciprocal) (NN loop) (NN replacement) (NN mutant)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD retained) (NP (NN _PROT_)) (PP (IN like) (NP (NP (NN affinity)) (PP (PP (IN for) (NP (NN _PROT_))) (CC and) (PP (IN for) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ reciprocal) (NN loop) (NN replacement) (NN mutant)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD retained) (NP (NN _PROT1_)) (PP (IN like) (NP (NP (NN affinity)) (PP (PP (IN for) (NP (NN _PROT2_))) (CC and) (PP (IN for) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ reciprocal) (NN loop) (NN replacement) (NN mutant)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD retained) (NP (NN _PROT1_)) (PP (IN like) (NP (NP (NN affinity)) (PP (PP (IN for) (NP (NN _PROT_))) (CC and) (PP (IN for) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ reciprocal) (NN loop) (NN replacement) (NN mutant)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD retained) (NP (NN _PROT_)) (PP (IN like) (NP (NP (NN affinity)) (PP (PP (IN for) (NP (NN _PROT1_))) (CC and) (PP (IN for) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Type) (NN I) (NNS interferons)) (VP (VBP bind) (PP (TO to) (NP (NP (CD two) (NN cell) (NN surface) (NNS receptors)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,))) (PP (IN as) (NP (NP (DT the) (JJ first) (NN step)) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (JJ several) (NN signal) (NN transduction) (NNS pathways)) (SBAR (WHNP (WDT that)) (S (VP (VBP elicit) (NP (NP (DT an) (JJ anti-viral) (NN state)) (CC and) (NP (DT an) (JJ anti-proliferative) (NN response)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (ADVP (RB quantitatively)) (VP (VBD mapped) (NP (NP (DT the) (JJ complete) (NN binding) (NN region)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))) (PP (IN by) (NP (CD 35) (JJ individual) (NNS mutations))) (PP (TO to) (NP (NP (NN alanine)) (CC and) (NP (JJ isosteric) (NNS residues))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (DT the) (NN _PROT1_) (NN binding) (NN site)) (VP (VBZ overlaps) (NP (NP (DT the) (JJS largest) (JJ continuous) (JJ hydrophobic) (NN patch)) (PP (IN on) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Relating) (S (NP (NP (DT the) (ADJP (ADJP (JJ anti-viral)) (CC and) (ADJP (JJ anti-proliferative))) (NN activity)) (PP (IN of) (NP (DT the) (JJ various) (NN interferon) (NNS mutants))) (PP (IN with) (NP (NP (PRP$ their) (NN affinity)) (PP (IN toward) (NP (NN _PROT1_)))))) (VP (VBZ results) (PP (IN in) (NP (NP (JJ linear) (NN function)) (PP (IN over) (NP (NP (DT the) (JJ whole) (NN range)) (PP (IN of) (NP (NP (NNS affinities)) (VP (VBN investigated)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN binding)) (VP (VBZ is) (NP (NP (DT the) (JJ rate-determining) (NN step)) (PP (IN in) (NP (JJ cellular) (NN activation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ novel) (NN growth) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN beta) (NN receptor)))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ novel) (NN growth) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN beta) (NN receptor)))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ novel) (NN growth) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN beta) (NN receptor)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN multidomain) (NN protein)) (PP (IN with) (NP (NP (DT the) (JJ N-terminal) (NN region)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN CUB) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ C-terminal) (NN region)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (DT a) (NN growth) (NN factor) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN GFD)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NP (NP (JJ vascular) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 25) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 23) (NN %)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN multidomain) (NN protein)) (PP (IN with) (NP (NP (DT the) (JJ N-terminal) (NN region)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN CUB) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ C-terminal) (NN region)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (DT a) (NN growth) (NN factor) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN GFD)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NP (NP (JJ vascular) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 25) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 23) (NN %)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN multidomain) (NN protein)) (PP (IN with) (NP (NP (DT the) (JJ N-terminal) (NN region)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN CUB) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ C-terminal) (NN region)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (DT a) (NN growth) (NN factor) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN GFD)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NP (NP (JJ vascular) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 25) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 23) (NN %)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN multidomain) (NN protein)) (PP (IN with) (NP (NP (DT the) (JJ N-terminal) (NN region)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN CUB) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ C-terminal) (NN region)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (DT a) (NN growth) (NN factor) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN GFD)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NP (NP (JJ vascular) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 25) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 23) (NN %)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN multidomain) (NN protein)) (PP (IN with) (NP (NP (DT the) (JJ N-terminal) (NN region)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN CUB) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ C-terminal) (NN region)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (DT a) (NN growth) (NN factor) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN GFD)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NP (NP (JJ vascular) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 25) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 23) (NN %)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN multidomain) (NN protein)) (PP (IN with) (NP (NP (DT the) (JJ N-terminal) (NN region)) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN CUB) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ C-terminal) (NN region)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (DT a) (NN growth) (NN factor) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN GFD)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NP (NP (JJ vascular) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 25) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 23) (NN %)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Competition) (NN binding) (CC and) (NN immunoprecipitation) (NNS studies)) (PP (IN on) (NP (NP (NNS cells)) (VP (VBG bearing) (NP (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (NNS receptors)))))) (VP (VBP reveal) (NP (NP (DT a) (JJ high) (NN affinity) (NN binding)) (PP (IN of) (NP (NP (JJ recombinant) (NN GFD)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (NNS homodimers)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS heterodimers))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Competition) (NN binding) (CC and) (NN immunoprecipitation) (NNS studies)) (PP (IN on) (NP (NP (NNS cells)) (VP (VBG bearing) (NP (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (NNS receptors)))))) (VP (VBP reveal) (NP (NP (DT a) (JJ high) (NN affinity) (NN binding)) (PP (IN of) (NP (NP (JJ recombinant) (NN GFD)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (NNS homodimers)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS heterodimers))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Competition) (NN binding) (CC and) (NN immunoprecipitation) (NNS studies)) (PP (IN on) (NP (NP (NNS cells)) (VP (VBG bearing) (NP (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (NNS receptors)))))) (VP (VBP reveal) (NP (NP (DT a) (JJ high) (NN affinity) (NN binding)) (PP (IN of) (NP (NP (JJ recombinant) (NN GFD)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (NNS homodimers)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS heterodimers))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Competition) (NN binding) (CC and) (NN immunoprecipitation) (NNS studies)) (PP (IN on) (NP (NP (NNS cells)) (VP (VBG bearing) (NP (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (NNS receptors)))))) (VP (VBP reveal) (NP (NP (DT a) (JJ high) (NN affinity) (NN binding)) (PP (IN of) (NP (NP (JJ recombinant) (NN GFD)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (NNS homodimers)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS heterodimers))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Competition) (NN binding) (CC and) (NN immunoprecipitation) (NNS studies)) (PP (IN on) (NP (NP (NNS cells)) (VP (VBG bearing) (NP (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (NNS receptors)))))) (VP (VBP reveal) (NP (NP (DT a) (JJ high) (NN affinity) (NN binding)) (PP (IN of) (NP (NP (JJ recombinant) (NN GFD)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (NNS homodimers)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS heterodimers))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Competition) (NN binding) (CC and) (NN immunoprecipitation) (NNS studies)) (PP (IN on) (NP (NP (NNS cells)) (VP (VBG bearing) (NP (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (NNS receptors)))))) (VP (VBP reveal) (NP (NP (DT a) (JJ high) (NN affinity) (NN binding)) (PP (IN of) (NP (NP (JJ recombinant) (NN GFD)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (NNS homodimers)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS heterodimers))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ exhibits) (NP (NP (JJR greater) (JJ mitogenic) (NN potency)) (PP (IN than) (NP (NP (NN _PROT2_)) (CC and) (NP (ADJP (ADJP (JJ comparable)) (CC or) (ADJP (JJR greater))) (JJ mitogenic) (NN activity)))) (PP (IN than) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (PP (IN on) (NP (JJ several) (JJ mesenchymal) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ exhibits) (NP (NP (JJR greater) (JJ mitogenic) (NN potency)) (PP (IN than) (NP (NP (NN _PROT_)) (CC and) (NP (ADJP (ADJP (JJ comparable)) (CC or) (ADJP (JJR greater))) (JJ mitogenic) (NN activity)))) (PP (IN than) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (PP (IN on) (NP (JJ several) (JJ mesenchymal) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ exhibits) (NP (NP (JJR greater) (JJ mitogenic) (NN potency)) (PP (IN than) (NP (NP (NN _PROT_)) (CC and) (NP (ADJP (ADJP (JJ comparable)) (CC or) (ADJP (JJR greater))) (JJ mitogenic) (NN activity)))) (PP (IN than) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (PP (IN on) (NP (JJ several) (JJ mesenchymal) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ exhibits) (NP (NP (JJR greater) (JJ mitogenic) (NN potency)) (PP (IN than) (NP (NP (NN _PROT1_)) (CC and) (NP (ADJP (ADJP (JJ comparable)) (CC or) (ADJP (JJR greater))) (JJ mitogenic) (NN activity)))) (PP (IN than) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (PP (IN on) (NP (JJ several) (JJ mesenchymal) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ exhibits) (NP (NP (JJR greater) (JJ mitogenic) (NN potency)) (PP (IN than) (NP (NP (NN _PROT1_)) (CC and) (NP (ADJP (ADJP (JJ comparable)) (CC or) (ADJP (JJR greater))) (JJ mitogenic) (NN activity)))) (PP (IN than) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (PP (IN on) (NP (JJ several) (JJ mesenchymal) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ exhibits) (NP (NP (JJR greater) (JJ mitogenic) (NN potency)) (PP (IN than) (NP (NP (NN _PROT_)) (CC and) (NP (ADJP (ADJP (JJ comparable)) (CC or) (ADJP (JJR greater))) (JJ mitogenic) (NN activity)))) (PP (IN than) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN on) (NP (JJ several) (JJ mesenchymal) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NN _PROT1_))) (ADVP (FW in) (FW vivo)) (PP (IN in) (NP (NP (DT a) (JJ diabetic) (NN mouse) (NN model)) (PP (IN of) (NP (VBN delayed) (NN wound) (NN healing)))))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB significantly)) (VP (VBD enhanced) (NP (NP (NN repair)) (PP (IN of) (NP (DT a) (JJ full-thickness) (NN skin) (NN excision))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Together)) (, ,) (NP (DT these) (NNS studies)) (VP (VBP describe) (NP (NP (DT a) (JJ third) (NN member)) (PP (IN of) (NP (NP (DT the) (NN PDGF) (NN family)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN as) (NP (NP (DT a) (JJ potent) (NN mitogen)) (PP (IN for) (NP (NP (NNS cells)) (PP (IN of) (NP (JJ mesenchymal) (NN origin))) (PP (IN in) (NP (NP (ADJP (ADJP (FW in) (FW vitro)) (CC and) (ADJP (FW in) (FW vivo))) (NNS systems)) (PP (IN with) (NP (NP (DT a) (NN binding) (NN pattern)) (ADJP (JJ similar) (PP (TO to) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Cloning)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN on) (NP (JJ human) (NN T) (NNS cells)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN cDNA) (NN clone)) (, ,) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN isolated) (PP (IN from) (NP (NP (DT a) (NN collection)) (PP (IN of) (NP (NN T) (NN cell) (NN activation) (NNS genes)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (RB highly) (JJ similar) (PP (PP (TO to) (NP (DT an) (VBN identified) (JJ murine) (NN _PROT2_) (NN _PROT2_))) (CC both) (PP (IN at) (NP (NP (NP (DT the) (NN cDNA)) (PRN (-LRB- -LRB-) (NP (CD 82.8) (NN %) (NN identity)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 77.4) (NN %) (NN identity)) (-RRB- -RRB-))) (NNS levels)))) (, ,) (CC and) (PP (JJ related) (TO to) (NP (NN tumor) (NN necrosis) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (RB highly) (JJ similar) (PP (PP (TO to) (NP (DT an) (VBN identified) (JJ murine) (NN _PROT_) (NN _PROT_))) (CC both) (PP (IN at) (NP (NP (NP (DT the) (NN cDNA)) (PRN (-LRB- -LRB-) (NP (CD 82.8) (NN %) (NN identity)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 77.4) (NN %) (NN identity)) (-RRB- -RRB-))) (NNS levels)))) (, ,) (CC and) (PP (JJ related) (TO to) (NP (NN tumor) (NN necrosis) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VBZ is) (ADJP (RB highly) (JJ similar) (PP (PP (TO to) (NP (DT an) (VBN identified) (JJ murine) (NN _PROT1_) (NN _PROT1_))) (CC both) (PP (IN at) (NP (NP (NP (DT the) (NN cDNA)) (PRN (-LRB- -LRB-) (NP (CD 82.8) (NN %) (NN identity)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 77.4) (NN %) (NN identity)) (-RRB- -RRB-))) (NNS levels)))) (, ,) (CC and) (PP (JJ related) (TO to) (NP (NN tumor) (NN necrosis) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Expressed) (PP (IN in) (NP (DT a) (JJ murine) (NN myeloma))))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN identified) (PP (IN as) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (DT a) (JJ soluble) (NN _PROT_) (NN construct))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Expressed) (PP (IN in) (NP (DT a) (JJ murine) (NN myeloma))))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN identified) (PP (IN as) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (DT a) (JJ soluble) (NN _PROT2_) (NN construct))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Expressed) (PP (IN in) (NP (DT a) (JJ murine) (NN myeloma))))) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN identified) (PP (IN as) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (NN _PROT1_))))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (DT a) (JJ soluble) (NN _PROT2_) (NN construct))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Activation)) (PP (IN of) (NP (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (PP (IN by) (NP (NN _PROT_))) (PP (PP (IN in) (NP (NN NIH) (NN 3T3) (NNS cells))) (CC and) (PP (IN in) (NP (FW vitro)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Activation)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_))) (PP (IN by) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (NN NIH) (NN 3T3) (NNS cells))) (CC and) (PP (IN in) (NP (FW vitro)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Activation)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (IN by) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (NN NIH) (NN 3T3) (NNS cells))) (CC and) (PP (IN in) (NP (FW vitro)))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN protein) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (PRP it))))))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBD were) (ADVP (RB constitutively)) (VP (VBN activated) (PP (IN in) (NP (NP (NN NIH) (NN 3T3) (NNS cells)) (VP (VBN infected) (PP (IN with) (NP (NP (NNS viruses)) (VP (VBG containing) (NP (NP (DT either)) (PP (IN of) (NP (NP (NP (CD two) (JJ oncogenic) (NNS forms)) (PRN (-LRB- -LRB-) (NP (NP (NN p35EC12)) (, ,) (NP (NN p3722W))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein) (NN kinase))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN protein) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (PRP it))))))) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD were) (ADVP (RB constitutively)) (VP (VBN activated) (PP (IN in) (NP (NP (NN NIH) (NN 3T3) (NNS cells)) (VP (VBN infected) (PP (IN with) (NP (NP (NNS viruses)) (VP (VBG containing) (NP (NP (DT either)) (PP (IN of) (NP (NP (NP (CD two) (JJ oncogenic) (NNS forms)) (PRN (-LRB- -LRB-) (NP (NP (NN p35EC12)) (, ,) (NP (NN p3722W))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN protein) (NN kinase))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN protein) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (PRP it))))))) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD were) (ADVP (RB constitutively)) (VP (VBN activated) (PP (IN in) (NP (NP (NN NIH) (NN 3T3) (NNS cells)) (VP (VBN infected) (PP (IN with) (NP (NP (NNS viruses)) (VP (VBG containing) (NP (NP (DT either)) (PP (IN of) (NP (NP (NP (CD two) (JJ oncogenic) (NNS forms)) (PRN (-LRB- -LRB-) (NP (NP (NN p35EC12)) (, ,) (NP (NN p3722W))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN protein) (NN kinase))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NNS proteins)) (VP (VBN purified) (PP (IN from) (NP (NP (NNS cells)) (VP (VBN infected) (PP (IN with) (NP (NP (NN EC12)) (CC or) (NP (NN 22W)) (NP (NNS viruses))))))))) (VP (VBD activated) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PP (IN from) (NP (JJ skeletal) (NN muscle)))) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NNS proteins)) (VP (VBN purified) (PP (IN from) (NP (NP (NNS cells)) (VP (VBN infected) (PP (IN with) (NP (NP (NN EC12)) (CC or) (NP (NN 22W)) (NP (NNS viruses))))))))) (VP (VBD activated) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ skeletal) (NN muscle)))) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NNS proteins)) (VP (VBN purified) (PP (IN from) (NP (NP (NNS cells)) (VP (VBN infected) (PP (IN with) (NP (NP (NN EC12)) (CC or) (NP (NN 22W)) (NP (NNS viruses))))))))) (VP (VBD activated) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PP (IN from) (NP (JJ skeletal) (NN muscle)))) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (ADJP (RB bacterially) (VBN expressed)) (NN _PROT1_) (NN fusion) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN glutathione) (NN S-transferase-p3722W)) (-RRB- -RRB-))) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (ADJP (RB bacterially) (VBN expressed)) (NN _PROT1_) (NN fusion) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN glutathione) (NN S-transferase-p3722W)) (-RRB- -RRB-))) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (ADJP (RB bacterially) (VBN expressed)) (NN _PROT_) (NN fusion) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN glutathione) (NN S-transferase-p3722W)) (-RRB- -RRB-))) (ADVP (RB also)) (VP (VBD activated) (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (JJ mitogenic) (NN signaling)))) (VP (VBZ is) (S (VP (TO to) (VP (VP (VB phosphorylate)) (CC and) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (JJ mitogenic) (NN signaling)))) (VP (VBZ is) (S (VP (TO to) (VP (VP (VB phosphorylate)) (CC and) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mitogenic) (NN signaling)))) (VP (VBZ is) (S (VP (TO to) (VP (VP (VB phosphorylate)) (CC and) (VP (VB activate) (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBN cloned) (NN _PROT1_) (NN gene)) (VP (VBZ encodes) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT a) (NN protein) (NN family))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (DT the) (NN yeast) (NN _PROT2_) (NN protein)) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (DT the) (JJ transcriptional) (NN regulator) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBN cloned) (NN _PROT1_) (NN gene)) (VP (VBZ encodes) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT a) (NN protein) (NN family))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (DT the) (NN yeast) (NN _PROT_) (NN protein)) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (DT the) (JJ transcriptional) (NN regulator) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBN cloned) (NN _PROT1_) (NN gene)) (VP (VBZ encodes) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT a) (NN protein) (NN family))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (DT the) (NN yeast) (NN _PROT_) (NN protein)) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (DT the) (JJ transcriptional) (NN regulator) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBN cloned) (NN _PROT_) (NN gene)) (VP (VBZ encodes) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT a) (NN protein) (NN family))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (DT the) (NN yeast) (NN _PROT1_) (NN protein)) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (DT the) (JJ transcriptional) (NN regulator) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBN cloned) (NN _PROT_) (NN gene)) (VP (VBZ encodes) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT a) (NN protein) (NN family))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (DT the) (NN yeast) (NN _PROT1_) (NN protein)) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (DT the) (JJ transcriptional) (NN regulator) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBN cloned) (NN _PROT_) (NN gene)) (VP (VBZ encodes) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT a) (NN protein) (NN family))) (SBAR (WHNP (WDT that)) (S (VP (VBZ includes) (NP (NP (DT the) (NN yeast) (NN _PROT_) (NN protein)) (, ,) (NP (NP (DT a) (NN component)) (PP (IN of) (NP (DT the) (JJ transcriptional) (NN regulator) (NN _PROT1_AND_PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN protein)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT2_) (NN protein))) (CC and) (PP (IN with) (NP (NP (NN _PROT_) (NN protein)) (, ,) (NP (NP (DT a) (NN subunit)) (PP (IN of) (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II) (NP (NN transcription) (NN factor) (NN IIH)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN protein)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_) (NN protein))) (CC and) (PP (IN with) (NP (NP (NN _PROT2_) (NN protein)) (, ,) (NP (NP (DT a) (NN subunit)) (PP (IN of) (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II) (NP (NN transcription) (NN factor) (NN IIH)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN protein)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_) (NN protein))) (CC and) (PP (IN with) (NP (NP (NN _PROT2_) (NN protein)) (, ,) (NP (NP (DT a) (NN subunit)) (PP (IN of) (NP (DT the) (JJ human) (NN RNA) (NN polymerase) (CD II) (NP (NN transcription) (NN factor) (NN IIH)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS observations)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS genes)))) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_))))) (: :) (NP (NP (CD three) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ human) (NN transcription) (NN factor) (NN _PROT_)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_))))) (: :) (NP (NP (CD three) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ human) (NN transcription) (NN factor) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))) (: :) (NP (NP (CD three) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ human) (NN transcription) (NN factor) (NN _PROT2_)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (CD _PROT2_))))) (: :) (NP (NP (CD three) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ human) (NN transcription) (NN factor) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (CD _PROT_))))) (: :) (NP (NP (CD three) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ human) (NN transcription) (NN factor) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (CD _PROT1_))))) (: :) (NP (NP (CD three) (NNS subunits)) (PP (IN of) (NP (DT the) (JJ human) (NN transcription) (NN factor) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT2_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT2_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT2_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT2_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT2_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT2_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT2_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT2_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT1_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT2_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT2_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT2_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT1_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT2_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT2_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT1_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT2_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT1_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT2_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT1_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT2_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT1_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT1_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (CD three) (JJ novel) (NN TAFIIs) (NN _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -associated) (NNS factors))) (-RRB- -RSB-)) (PP (IN from) (NP (DT the) (ADJP (ADJP (JJ human)) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-))) (NN HeLa) (NN cell) (NN _PROT_) (NNS complexes) (NP (NP (CD _PROT_)) (, ,) (NP (CD _PROT_)) (CC and) (NP (NN _PROT_) (CD _PROT_)))))))) (VP (VP (VBZ is) (NP (NP (DT a) (NN core) (NN _PROT_)) (ADJP (JJ present) (PP (IN in) (NP (NP (DT both)) (PP (IN of) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN _PROT_) (NNS species)) (SBAR (WHNP (WDT which)) (S (VP (CC either) (VP (VBP lack)) (CC or) (VP (VBP contain) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (ADVP (RB respectively))) (-RRB- -RRB-)))))))))))))) (, ,) (CC and) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN Drosophila) (-LRB- -LRB-) (NN d) (-RRB- -RRB-) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN _PROT1_)) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ shows) (NP (NP (NN homology)) (PP (TO to) (NP (NP (DT the) (JJ N-terminal) (NN region)) (PP (IN of) (NP (DT the) (NN yeast) (NN _PROT2_))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (JJ known) (NN Drosophila) (NN counterpart))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT2_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT2_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT1_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT2_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT2_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT_) (NN _PROT2_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT_) (NN _PROT_) (CD _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT2_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT_) (CD _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT1_) (CD _PROT2_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT1_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT1_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT1_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN contrast)) (PP (TO to) (NP (CD _PROT_))))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (VP (VBZ is) (NP (NP (DT the) (NN homologue)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (S (NP (CD _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (RB intracellularly))))) (: ;) (S (PP (IN in) (NN contrast) (TO to) (NP (PRP$ its) (NN Drosophila) (NN homologue))) (, ,) (NP (CD _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (S (NP (CD _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (RB intracellularly))))) (: ;) (S (PP (IN in) (NN contrast) (TO to) (NP (PRP$ its) (NN Drosophila) (NN homologue))) (, ,) (NP (CD _PROT2_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (S (NP (CD _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (RB intracellularly))))) (: ;) (S (PP (IN in) (NN contrast) (TO to) (NP (PRP$ its) (NN Drosophila) (NN homologue))) (, ,) (NP (CD _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (S (NP (CD _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (RB intracellularly))))) (: ;) (S (PP (IN in) (NN contrast) (TO to) (NP (PRP$ its) (NN Drosophila) (NN homologue))) (, ,) (NP (CD _PROT2_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (S (NP (CD _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (RB intracellularly))))) (: ;) (S (PP (IN in) (NN contrast) (TO to) (NP (PRP$ its) (NN Drosophila) (NN homologue))) (, ,) (NP (CD _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (S (NP (CD _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (RB intracellularly))))) (: ;) (S (PP (IN in) (NN contrast) (TO to) (NP (PRP$ its) (NN Drosophila) (NN homologue))) (, ,) (NP (CD _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT2_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT2_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT2_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT2_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT1_) (S (S (NP (NN _PROT2_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT1_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT1_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT1_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Deletion) (NN analysis)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (S (VP (VBG _PROT_) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_))))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ interacts) (ADVP (RBR more) (RB strongly)) (PP (IN with) (NP (NP (CD _PROT1_)) (CC and) (NP (CD _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (CD _PROT1_)) (CC and) (NP (CD _PROT2_))))) (VP (VBZ requires) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (CD _PROT1_)) (CC and) (NP (CD _PROT_))))) (VP (VBZ requires) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT1_))))) (VP (VBZ requires) (NP (NP (JJ distinct) (NNS domains)) (PP (IN of) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT1_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT2_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_)) (CC or) (NP (CD _PROT_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT1_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_)) (CC or) (NP (CD _PROT_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT1_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_)) (CC or) (NP (CD _PROT_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT1_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_)) (CC or) (NP (CD _PROT2_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT1_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT2_)) (CC and) (NP (CD _PROT_)) (CC or) (NP (CD _PROT_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT1_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT2_)) (CC or) (NP (CD _PROT_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT1_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT_)) (CC or) (NP (CD _PROT2_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT1_)) (CC and) (NP (CD _PROT2_)) (CC or) (NP (CD _PROT_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT1_)) (CC and) (NP (CD _PROT_)) (CC or) (NP (CD _PROT2_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN As) (S (VP (VBN observed) (PP (IN with) (NP (DT the) (JJ homologous) (NN Drosophila) (NNS proteins)))))) (, ,) (NP (CD _PROT_)) (VP (VBZ interacts) (ADVP (RB directly)) (PP (IN with) (NP (NN _PROT_))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (JJ additional) (NNS interactions)) (PP (IN between) (NP (NP (CD _PROT_)) (CC and) (NP (CD _PROT1_)) (CC or) (NP (CD _PROT2_))))) (VP (VBD were) (VP (VBN detected)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP reveal) (NP (NP (NNS differences)) (PP (CONJP (RB not) (RB only)) (PP (IN in) (NP (NN subunit) (NN composition))) (, ,) (CONJP (CC but) (RB also)) (PP (IN in) (NP (NP (DT the) (NN organization)) (PP (IN of) (NP (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT2_))) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (JJ transcriptional) (NN activation)) (VP (VBN mediated) (PP (IN by) (NP (NNS coactivators) (CD _PROT2_) (CC and) (CD _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (JJ transcriptional) (NN activation)) (VP (VBN mediated) (PP (IN by) (NP (NNS coactivators) (CD _PROT_) (CC and) (CD _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (JJ transcriptional) (NN activation)) (VP (VBN mediated) (PP (IN by) (NP (NNS coactivators) (CD _PROT1_) (CC and) (CD _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ multisubunit) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB be) (NP (NP (DT a) (JJ primary) (NN target)) (PP (IN for) (NP (NP (JJ site-specific) (NNS activators)) (PP (IN of) (NP (NN transcription)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (CD two) (NNS subunits)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,))))))) (VP (VBZ is) (VP (VBN reported)))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (CD two) (NNS subunits)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,))))))) (VP (VBZ is) (VP (VBN reported)))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (CD two) (NNS subunits)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,))))))) (VP (VBZ is) (VP (VBN reported)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (CD two) (NNS subunits)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN complex)))) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,))))))) (VP (VBZ is) (VP (VBN reported)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (CD two) (NNS subunits)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN complex)))) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,))))))) (VP (VBZ is) (VP (VBN reported)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (CD two) (NNS subunits)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,))))))) (VP (VBZ is) (VP (VBN reported)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ double) (NN point) (NN mutation)) (PP (IN in) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD impaired) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (DT this) (NN domain))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (CC and) (, ,) (ADVP (RB simultaneously)) (, ,) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ double) (NN point) (NN mutation)) (PP (IN in) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD impaired) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (DT this) (NN domain))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (CC and) (, ,) (ADVP (RB simultaneously)) (, ,) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ double) (NN point) (NN mutation)) (PP (IN in) (NP (NP (DT the) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD impaired) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (DT this) (NN domain))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (CC and) (, ,) (ADVP (RB simultaneously)) (, ,) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT2_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT2_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT2_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT2_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT2_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT2_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT1_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT1_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT a) (JJ partial) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NP (NP (NN Drosophila) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD supported) (NP (NP (NN activation)) (PP (IN by) (NP (DT a) (NN Gal4-p53) (NN fusion) (NN protein)))) (ADVP (FW in) (FW vitro)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN subcomplex)) (VP (VBG lacking) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (VP (VBD did) (RB not))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Together)) (, ,) (NP (DT these) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (NP (NP (JJ important) (NNS targets)) (PP (IN for) (S (VP (VBG transmitting) (NP (NP (NN activation) (NNS signals)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN initiation) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Together)) (, ,) (NP (DT these) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (NP (NP (JJ important) (NNS targets)) (PP (IN for) (S (VP (VBG transmitting) (NP (NP (NN activation) (NNS signals)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN initiation) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Together)) (, ,) (NP (DT these) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP are) (NP (NP (JJ important) (NNS targets)) (PP (IN for) (S (VP (VBG transmitting) (NP (NP (NN activation) (NNS signals)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN initiation) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN beta) (: :) (NN _PROT1_) (NN _PROT1_) (NN homodimer)) (CC and) (NP (NN alpha) (: :) (NN _PROT2_) (NN _PROT2_) (NN heterodimer))) (VP (VBP are) (NP (NP (JJ mutual) (NNS antagonists)) (SBAR (WHNP (WDT which)) (S (VP (VBP share) (NP (DT a) (JJ common) (NN beta) (NN subunit)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activin) (NN type) (NN I) (NNS receptors)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,)) (VP (VBD were) (ADVP (RB first)) (VP (VBN cloned) (PP (IN from) (NP (ADJP (RB well) (VBN differentiated)) (NP (NP (JJ human) (NN hepatoma) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN HepG2)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT2_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT2_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT2_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT2_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT2_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT2_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN beta) (: :) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT which)) (S (VP (VBZ induces) (NP (NP (NN activin) (NN binding)) (PP (TO to) (NP (DT the) (NN type) (NN I) (NN receptor) (NN kinase) (NN _PROT1_)))) (S (VP (TO to) (VP (VB form) (NP (NP (NN _PROT2_)) (: :) (NP (NN beta))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NNS complexes)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (DT an) (NN _PROT2_) (NN _PROT2_) (NN chain)) (VP (VBZ occupies) (NP (DT each) (NN receptor) (NN subunit))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VP (VBZ binds) (PP (TO to) (NP (NN _PROT2_))) (PP (IN through) (NP (PRP$ its) (NN beta) (NN subunit)))) (, ,) (VP (VBZ competes) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN activin))) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC but) (VP (VBZ fails) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VP (VBZ binds) (PP (TO to) (NP (NN _PROT_))) (PP (IN through) (NP (PRP$ its) (NN beta) (NN subunit)))) (, ,) (VP (VBZ competes) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN activin))) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC but) (VP (VBZ fails) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VP (VBZ binds) (PP (TO to) (NP (NN _PROT_))) (PP (IN through) (NP (PRP$ its) (NN beta) (NN subunit)))) (, ,) (VP (VBZ competes) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN activin))) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC but) (VP (VBZ fails) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VP (VBZ binds) (PP (TO to) (NP (NN _PROT1_))) (PP (IN through) (NP (PRP$ its) (NN beta) (NN subunit)))) (, ,) (VP (VBZ competes) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN activin))) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC but) (VP (VBZ fails) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VP (VBZ binds) (PP (TO to) (NP (NN _PROT1_))) (PP (IN through) (NP (PRP$ its) (NN beta) (NN subunit)))) (, ,) (VP (VBZ competes) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN activin))) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC but) (VP (VBZ fails) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VP (VBZ binds) (PP (TO to) (NP (NN _PROT_))) (PP (IN through) (NP (PRP$ its) (NN beta) (NN subunit)))) (, ,) (VP (VBZ competes) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN activin))) (PP (TO to) (NP (NN _PROT1_)))))) (, ,) (CC but) (VP (VBZ fails) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Several) (JJ hydrophobic) (NN amino) (NNS acids)) (PP (IN in) (NP (DT the) (NN _PROT1_) (JJ amino-terminal) (NN domain)))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))) (CC and) (NP (DT the) (NP (NN adenovirus) (CD _PROT_) (NN _PROT_) (JJ 55-kD) (NN protein)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Several) (JJ hydrophobic) (NN amino) (NNS acids)) (PP (IN in) (NP (DT the) (NN _PROT1_) (JJ amino-terminal) (NN domain)))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))) (CC and) (NP (DT the) (NP (NN adenovirus) (CD _PROT_) (NN _PROT2_) (JJ 55-kD) (NN protein)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Several) (JJ hydrophobic) (NN amino) (NNS acids)) (PP (IN in) (NP (DT the) (NN _PROT1_) (JJ amino-terminal) (NN domain)))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))) (CC and) (NP (DT the) (NP (NN adenovirus) (CD _PROT2_) (NN _PROT2_) (JJ 55-kD) (NN protein)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Several) (JJ hydrophobic) (NN amino) (NNS acids)) (PP (IN in) (NP (DT the) (NN _PROT_) (JJ amino-terminal) (NN domain)))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT1_)))) (CC and) (NP (DT the) (NP (NN adenovirus) (CD _PROT_) (NN _PROT2_) (JJ 55-kD) (NN protein)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Several) (JJ hydrophobic) (NN amino) (NNS acids)) (PP (IN in) (NP (DT the) (NN _PROT_) (JJ amino-terminal) (NN domain)))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT1_)))) (CC and) (NP (DT the) (NP (NN adenovirus) (CD _PROT2_) (NN _PROT2_) (JJ 55-kD) (NN protein)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Several) (JJ hydrophobic) (NN amino) (NNS acids)) (PP (IN in) (NP (DT the) (NN _PROT_) (JJ amino-terminal) (NN domain)))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))) (CC and) (NP (DT the) (NP (NN adenovirus) (CD _PROT2_) (NN _PROT1_AND_PROT2_) (JJ 55-kD) (NN protein)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ acidic) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein)))) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB contain) (NP (NP (DT this) (NN trans-activation) (NN activity)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NNS domains)) (PP (IN for) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN adenovirus) (CD _PROT_) (NN _PROT_) (JJ 55-kD) (NN protein))) (NN binding)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ acidic) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein)))) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB contain) (NP (NP (DT this) (NN trans-activation) (NN activity)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NNS domains)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN adenovirus) (CD _PROT_) (NN _PROT2_) (JJ 55-kD) (NN protein))) (NN binding)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ acidic) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein)))) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB contain) (NP (NP (DT this) (NN trans-activation) (NN activity)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NNS domains)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN adenovirus) (CD _PROT2_) (NN _PROT2_) (JJ 55-kD) (NN protein))) (NN binding)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ acidic) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein)))) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB contain) (NP (NP (DT this) (NN trans-activation) (NN activity)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NNS domains)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN adenovirus) (CD _PROT_) (NN _PROT2_) (JJ 55-kD) (NN protein))) (NN binding)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ acidic) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein)))) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB contain) (NP (NP (DT this) (NN trans-activation) (NN activity)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NNS domains)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN adenovirus) (CD _PROT2_) (NN _PROT2_) (JJ 55-kD) (NN protein))) (NN binding)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ acidic) (NN amino) (NN terminus)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein)))) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB contain) (NP (NP (DT this) (NN trans-activation) (NN activity)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NNS domains)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN adenovirus) (CD _PROT2_) (NN _PROT1_AND_PROT2_) (JJ 55-kD) (NN protein))) (NN binding)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Rather)) (, ,) (NP (NP (DT the) (JJ hydrophobic) (NN amino) (NN acid) (NNS residues) (NP (NP (CD Leu-22)) (CC and) (NP (CD Trp-23)))) (PP (IN of) (NP (JJ human) (NN _PROT1_)))) (VP (VBP are) (DT both) (VP (VBN required) (PP (IN for) (NP (NP (NN trans-activation) (NN activity)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN adenovirus) (NN _PROT2_) (JJ 55-kD) (NN protein)))) (CC and) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)))) (ADVP (FW in) (FW vitro))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Rather)) (, ,) (NP (NP (DT the) (JJ hydrophobic) (NN amino) (NN acid) (NNS residues) (NP (NP (CD Leu-22)) (CC and) (NP (CD Trp-23)))) (PP (IN of) (NP (JJ human) (NN _PROT1_)))) (VP (VBP are) (DT both) (VP (VBN required) (PP (IN for) (NP (NP (NN trans-activation) (NN activity)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN adenovirus) (NN _PROT_) (JJ 55-kD) (NN protein)))) (CC and) (NP (DT the) (JJ human) (NN _PROT2_) (NN protein)))) (ADVP (FW in) (FW vitro))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Rather)) (, ,) (NP (NP (DT the) (JJ hydrophobic) (NN amino) (NN acid) (NNS residues) (NP (NP (CD Leu-22)) (CC and) (NP (CD Trp-23)))) (PP (IN of) (NP (JJ human) (NN _PROT1_)))) (VP (VBP are) (DT both) (VP (VBN required) (PP (IN for) (NP (NP (NN trans-activation) (NN activity)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN adenovirus) (NN _PROT_) (JJ 55-kD) (NN protein)))) (CC and) (NP (DT the) (JJ human) (NN _PROT2_) (NN protein)))) (ADVP (FW in) (FW vitro))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Rather)) (, ,) (NP (NP (DT the) (JJ hydrophobic) (NN amino) (NN acid) (NNS residues) (NP (NP (CD Leu-22)) (CC and) (NP (CD Trp-23)))) (PP (IN of) (NP (JJ human) (NN _PROT_)))) (VP (VBP are) (DT both) (VP (VBN required) (PP (IN for) (NP (NP (NN trans-activation) (NN activity)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN adenovirus) (NN _PROT1_) (JJ 55-kD) (NN protein)))) (CC and) (NP (DT the) (JJ human) (NN _PROT2_) (NN protein)))) (ADVP (FW in) (FW vitro))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Rather)) (, ,) (NP (NP (DT the) (JJ hydrophobic) (NN amino) (NN acid) (NNS residues) (NP (NP (CD Leu-22)) (CC and) (NP (CD Trp-23)))) (PP (IN of) (NP (JJ human) (NN _PROT_)))) (VP (VBP are) (DT both) (VP (VBN required) (PP (IN for) (NP (NP (NN trans-activation) (NN activity)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN adenovirus) (NN _PROT1_) (JJ 55-kD) (NN protein)))) (CC and) (NP (DT the) (JJ human) (NN _PROT2_) (NN protein)))) (ADVP (FW in) (FW vitro))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Rather)) (, ,) (NP (NP (DT the) (JJ hydrophobic) (NN amino) (NN acid) (NNS residues) (NP (NP (CD Leu-22)) (CC and) (NP (CD Trp-23)))) (PP (IN of) (NP (JJ human) (NN _PROT_)))) (VP (VBP are) (DT both) (VP (VBN required) (PP (IN for) (NP (NP (NN trans-activation) (NN activity)) (, ,) (NP (NP (NN binding)) (PP (TO to) (NP (DT the) (NN adenovirus) (NN _PROT_) (JJ 55-kD) (NN protein)))) (CC and) (NP (DT the) (JJ human) (NN _PROT1_AND_PROT2_) (NN protein)))) (ADVP (FW in) (FW vitro))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (JJ hydrophobic) (NNS residues)) (NP (NP (NN Leu-14)) (CC and) (NP (NN Phe-19)))) (VP (VBP are) (ADJP (JJ crucial) (PP (IN for) (NP (NP (DT the) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ human) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (JJ hydrophobic) (NNS residues)) (NP (NP (NN Leu-14)) (CC and) (NP (NN Phe-19)))) (VP (VBP are) (ADJP (JJ crucial) (PP (IN for) (NP (NP (DT the) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (JJ hydrophobic) (NNS residues)) (NP (NP (NN Leu-14)) (CC and) (NP (NN Phe-19)))) (VP (VBP are) (ADJP (JJ crucial) (PP (IN for) (NP (NP (DT the) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS mutations)) (VP (VBP have) (NP (DT no) (NN impact)) (PP (IN on) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein))) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (DT a) (JJ _PROT2_) (NN DNA) (NN element)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT These) (RB very) (JJ same) (JJ hydrophobic) (NNS residues)) (VP (NN contact) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN Ad5))) (NN _PROT2_) (JJ 55-kD) (NN oncogene) (NNS products))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ previous) (NNS studies)) (PRN (-LRB- -LRB-) (NP (NP (NP (NP (NP (NNP Scott) (, ,) (NNP J.) (NNP D.)) (, ,) (NP (NNP Stofko) (, ,) (NNP R.) (NNP E.) (, ,) (NNP McDonald) (, ,) (NNP J.) (NNP R.) (, ,) (NNP Comer) (, ,) (NNP J.) (NNP D.)) (, ,) (NP (NNP Vitalis) (, ,) (NNP E.) (NNP A.)) (, ,) (CC and) (NP (NNP Mangili) (NNP J)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1990)) (-RRB- -RRB-))) (NNP J.) (NNP Biol.) (NNP Chem.) (CD 265)) (, ,) (NP (CD 21561-21566))) (-RRB- -RRB-)))) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (PP (IN that) (S (NP (NP (NN dimerization)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN required) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (JJ cytoskeletal) (NN component) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Measurement)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (NP (NP (NNP I3A) (, ,) (NNP I5A) (NN interaction)) (PP (IN with) (NP (NP (DT the) (JJ human) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (CD _PROT_)) (, ,)))))) (PP (IN by) (NP (CD two) (JJ independent) (NNS methods)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN mutation)) (PP (IN of) (NP (NNS isoleucines) (CD 3) (CC and) (CD 5)))) (VP (VBZ decreases) (NP (NN affinity)) (PP (IN by) (ADVP (ADVP (IN at) (JJS least)) (RB 6-fold)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Measurement)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (NP (NP (NNP I3A) (, ,) (NNP I5A) (NN interaction)) (PP (IN with) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (CD _PROT2_)) (, ,)))))) (PP (IN by) (NP (CD two) (JJ independent) (NNS methods)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN mutation)) (PP (IN of) (NP (NNS isoleucines) (CD 3) (CC and) (CD 5)))) (VP (VBZ decreases) (NP (NN affinity)) (PP (IN by) (ADVP (ADVP (IN at) (JJS least)) (RB 6-fold)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Measurement)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (NP (NP (NNP I3A) (, ,) (NNP I5A) (NN interaction)) (PP (IN with) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (CD _PROT2_)) (, ,)))))) (PP (IN by) (NP (CD two) (JJ independent) (NNS methods)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN mutation)) (PP (IN of) (NP (NNS isoleucines) (CD 3) (CC and) (CD 5)))) (VP (VBZ decreases) (NP (NN affinity)) (PP (IN by) (ADVP (ADVP (IN at) (JJS least)) (RB 6-fold)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN protein))) (PP (IN with) (NP (NP (PRP itself)) (CC and) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family))) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))))) (VP (VBD were) (VP (VBN explored) (PP (IN with) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (CC and) (PP (IN with) (NP (NP (DT the) (JJ dominant) (NNS inhibitors)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD displayed) (NP (NP (DT the) (JJ same) (NN pattern)) (PP (IN of) (NP (NP (JJ combinatorial) (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT2_) (NN family) (NNS proteins)) (PP (IN as) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD displayed) (NP (NP (DT the) (JJ same) (NN pattern)) (PP (IN of) (NP (NP (JJ combinatorial) (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT_) (NN family) (NNS proteins)) (PP (IN as) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD displayed) (NP (NP (DT the) (JJ same) (NN pattern)) (PP (IN of) (NP (NP (JJ combinatorial) (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT1_) (NN family) (NNS proteins)) (PP (IN as) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT2_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT2_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT1_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT2_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT1_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT1_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT1_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT1_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT1_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Use)) (PP (IN of) (NP (NP (NN deletion) (NNS mutants)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD suggested) (SBAR (IN that) (S (NP (NN _PROT_) (NN homodimerization)) (VP (VBZ involves) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN protein)))))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN LexA) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT_) (NN amino) (NNS acids)) (CD 83-218)))) (VP (VP (VBD mediated) (NP (NP (JJ functional) (NNS interactions)) (PP (IN with) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT1_) (NN amino) (NNS acids)) (CD 1-81))))))) (CC but) (VP (VBD did) (RB not) (VP (VB complement) (NP (NP (DT a) (NN B42) (NN fusion) (NN protein)) (VP (VBG containing) (NP (NP (NN _PROT2_) (NN amino) (NNS acids)) (CD 83-218)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NN contrast) (TO to) (NP (NN _PROT1_) (NN fusion) (NNS proteins))) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN protein)))) (VP (VBD was) (ADJP (JJ lethal) (PP (TO to) (NP (NN yeast)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC or) (NP (NN _PROT_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT2_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT2_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC or) (NP (NN _PROT2_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC or) (NP (NN _PROT_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT2_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC or) (NP (NN _PROT_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT1_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT2_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT1_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN cytotoxicity)) (VP (MD could) (VP (VB be) (VP (VBN abrogated) (PP (IN by) (NP (NP (NN B42) (NN fusion) (NNS proteins)) (VP (VBG containing) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT_))) (CONJP (CC but) (RB not)) (NP (NP (NP (DT those)) (VP (VBG containing) (NP (NN _PROT1_)))) (-LRB- -LRB-) (NP (NP (DT an) (ADJP (RB alternatively) (VBN spliced)) (NN form)) (PP (IN of) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ lacks) (NP (DT a) (JJ well-conserved) (JJ 63-amino) (NN acid) (NN region)))))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT2_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT2_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT1_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT1_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT1_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT1_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT1_AND_PROT2_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT1_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT1_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT1_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT1_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP suggest) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB differentially)) (VP (VBP regulate) (NP (NN _PROT_) (NN function))))))) (, ,) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS requirements)) (PP (IN for) (NP (NN _PROT_) (NN heterodimerization)))) (VP (MD may) (VP (VB be) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (PP (IN for) (NP (NN _PROT1_AND_PROT2_) (NN homodimerization))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Expression) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT a) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN cDNA) (NNS clones)) (VP (VBG encoding) (NP (NP (DT a) (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN from) (NP (NP (DT a) (NN Burkitt) (NN lymphoma) (NN cell) (NN line)) (, ,) (NP (NN BJAB)) (, ,))))) (VP (VBP express) (NP (NP (DT a) (ADJP (QP (CD 90) (TO to) (CD 110)) (NN kDa)) (NN polypeptide)) (PP (IN in) (NP (NN COS7) (NNS cells))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT_)) (ADVP (RB specifically)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN cDNA) (NNS clones)) (VP (VBG encoding) (NP (NP (DT a) (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN from) (NP (NP (DT a) (NN Burkitt) (NN lymphoma) (NN cell) (NN line)) (, ,) (NP (NN BJAB)) (, ,))))) (VP (VBP express) (NP (NP (DT a) (ADJP (QP (CD 90) (TO to) (CD 110)) (NN kDa)) (NN polypeptide)) (PP (IN in) (NP (NN COS7) (NNS cells))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT2_)) (ADVP (RB specifically)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN cDNA) (NNS clones)) (VP (VBG encoding) (NP (NP (DT a) (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN from) (NP (NP (DT a) (NN Burkitt) (NN lymphoma) (NN cell) (NN line)) (, ,) (NP (NN BJAB)) (, ,))))) (VP (VBP express) (NP (NP (DT a) (ADJP (QP (CD 90) (TO to) (CD 110)) (NN kDa)) (NN polypeptide)) (PP (IN in) (NP (NN COS7) (NNS cells))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN _PROT2_)) (ADVP (RB specifically)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT2_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT2_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT2_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT2_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT1_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT1_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN predicted) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (ADJP (NP (CD 60) (NN %)) (JJ identical)) (CC and) (ADJP (NP (CD 73) (NN %)) (JJ similar) (PP (TO to) (NP (NP (NN mouse) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .)) (S (S (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (NP (DT an) (JJ _PROT_) (NN mouse) (JJ pro-B) (NN cell) (NN line)) (PRN (-LRB- -LRB-) (NP (NN Ba/F3)) (-RRB- -RRB-)))))) (VP (VBZ binds) (NP (NP (NN _PROT1_)) (PP (IN with) (NP (NP (JJ high) (NN affinity)) (PRN (-LRB- -LRB-) (NP (QP (CD 200) (TO to) (CD 250)) (NN pM)) (-RRB- -RRB-))))))) (, ,) (CC and) (S (NP (DT the) (VBN transfected) (NNS cells)) (VP (VBP exhibit) (NP (NP (DT a) (JJ proliferative) (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN Mouse) (NN _PROT1_)) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC and) (S (NP (NN _PROT_) (NN Ba/F3) (NNS cells)) (VP (VBP do) (RB not) (VP (VB respond) (PP (TO to) (NP (DT the) (NN mouse) (NN cytokine))) (, ,) (S (NP (NNS observations)) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ known) (NNS species) (NN specificity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN Mouse) (NN _PROT1_)) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT2_) (NN Ba/F3) (NNS cells)) (VP (VBP do) (RB not) (VP (VB respond) (PP (TO to) (NP (DT the) (NN mouse) (NN cytokine))) (, ,) (S (NP (NNS observations)) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ known) (NNS species) (NN specificity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN Mouse) (NN _PROT1_)) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT_) (NN Ba/F3) (NNS cells)) (VP (VBP do) (RB not) (VP (VB respond) (PP (TO to) (NP (DT the) (NN mouse) (NN cytokine))) (, ,) (S (NP (NNS observations)) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ known) (NNS species) (NN specificity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN Mouse) (NN _PROT_)) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT2_) (NN Ba/F3) (NNS cells)) (VP (VBP do) (RB not) (VP (VB respond) (PP (TO to) (NP (DT the) (NN mouse) (NN cytokine))) (, ,) (S (NP (NNS observations)) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ known) (NNS species) (NN specificity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN Mouse) (NN _PROT_)) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (NN _PROT_) (NN Ba/F3) (NNS cells)) (VP (VBP do) (RB not) (VP (VB respond) (PP (TO to) (NP (DT the) (NN mouse) (NN cytokine))) (, ,) (S (NP (NNS observations)) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ known) (NNS species) (NN specificity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN Mouse) (NN _PROT_)) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (NN _PROT1_) (NN Ba/F3) (NNS cells)) (VP (VBP do) (RB not) (VP (VB respond) (PP (TO to) (NP (DT the) (NN mouse) (NN cytokine))) (, ,) (S (NP (NNS observations)) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ known) (NNS species) (NN specificity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ human) (NN T) (NN cell) (NNS clones))))) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT1_) (NN mRNA)))) (VP (VBZ is) (VP (VBN down-regulated) (PP (IN after) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NNS cells))) (PP (IN with) (NP (NP (JJ _PROT2_) (NN Ab)) (CC and) (NP (NN phorbol) (NN ester))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Like) (NP (NN _PROT1_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (RB structurally) (JJ related) (PP (TO to) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Like) (NP (NN _PROT1_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (RB structurally) (JJ related) (PP (TO to) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (RB structurally) (JJ related) (PP (TO to) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NN macrophage) (NN activation)) (PP (IN by) (NP (NN _PROT2_)))))) (, ,) (NP (DT this) (NN relationship)) (VP (VBZ suggests) (NP (NP (JJ possible) (JJ shared) (NN receptor)) (CC or) (NP (NN signal) (NN transduction)) (NP (NN pathway) (NNS components))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS interactions)) (VP (VBP define) (NP (CD two) (JJ distinct) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN signal) (NN transduction) (NNS pathways)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Tumor) (NN necrosis) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN TNF)) (-RRB- -RRB-))) (VP (MD can) (VP (VP (VP (VB induce) (NP (NN apoptosis))) (CC and) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_)))) (PP (IN through) (NP (NP (NN signaling) (NNS cascades)) (VP (VBG emanating) (PP (IN from) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Tumor) (NN necrosis) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN TNF)) (-RRB- -RRB-))) (VP (MD can) (VP (VP (VP (VB induce) (NP (NN apoptosis))) (CC and) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_)))) (PP (IN through) (NP (NP (NN signaling) (NNS cascades)) (VP (VBG emanating) (PP (IN from) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Tumor) (NN necrosis) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN TNF)) (-RRB- -RRB-))) (VP (MD can) (VP (VP (VP (VB induce) (NP (NN apoptosis))) (CC and) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))) (PP (IN through) (NP (NP (NN signaling) (NNS cascades)) (VP (VBG emanating) (PP (IN from) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ _PROT2_) (NN signal) (NN transducer)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN involved) (PP (IN in) (S (VP (VBG activating) (NP (DT both) (NNS pathways)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (NN signal) (NNS transducers)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP activate) (NP (NN _PROT_) (NN _PROT_))) (CC and) (VP (VBP induce) (NP (NN apoptosis)) (, ,) (ADVP (RB respectively))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (NN signal) (NNS transducers)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP activate) (NP (NN _PROT_) (NN _PROT_))) (CC and) (VP (VBP induce) (NP (NN apoptosis)) (, ,) (ADVP (RB respectively))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (NN signal) (NNS transducers)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP activate) (NP (NN _PROT2_) (NN _PROT2_))) (CC and) (VP (VBP induce) (NP (NN apoptosis)) (, ,) (ADVP (RB respectively))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (NN signal) (NNS transducers)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP activate) (NP (NN _PROT_) (NN _PROT_))) (CC and) (VP (VBP induce) (NP (NN apoptosis)) (, ,) (ADVP (RB respectively))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (NN signal) (NNS transducers)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP activate) (NP (NN _PROT2_) (NN _PROT2_))) (CC and) (VP (VBP induce) (NP (NN apoptosis)) (, ,) (ADVP (RB respectively))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,) (NP (NP (NN signal) (NNS transducers)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP activate) (NP (NN _PROT2_) (NN _PROT2_))) (CC and) (VP (VBP induce) (NP (NN apoptosis)) (, ,) (ADVP (RB respectively))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN _PROT1_) (NN mutant)) (VP (VBG lacking) (NP (PRP$ its) (JJ N-terminal) (NN RING) (NN finger) (NN domain)))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ dominant-negative) (NN inhibitor)) (PP (IN of) (NP (JJ TNF-mediated) (NN _PROT2_) (NN _PROT2_) (NN activation))))) (, ,) (CC but) (VP (VBZ does) (RB not) (VP (VB affect) (NP (JJ TNF-induced) (NN apoptosis)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Conversely)) (, ,) (NP (NP (DT a) (NN _PROT1_) (NN mutant)) (VP (VBG lacking) (NP (PRP$ its) (JJ N-terminal) (CD 79) (NN amino) (NNS acids)))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ dominant-negative) (NN inhibitor)) (PP (IN of) (NP (JJ TNF-induced) (NN apoptosis))))) (, ,) (CC but) (VP (VBZ does) (RB not) (VP (VB inhibit) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (DT these) (CD two) (NN _PROT1_AND_PROT2_) (NN signaling) (NNS cascades)) (VP (VBP appear) (S (VP (TO to) (VP (VB bifurcate) (PP (IN at) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (DT these) (CD two) (NN _PROT1_) (NN signaling) (NNS cascades)) (VP (VBP appear) (S (VP (TO to) (VP (VB bifurcate) (PP (IN at) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (DT these) (CD two) (NN _PROT1_) (NN signaling) (NNS cascades)) (VP (VBP appear) (S (VP (TO to) (VP (VB bifurcate) (PP (IN at) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN cyclin-dependent-kinase) (NN inhibitor)))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN complex))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN cyclin-dependent-kinase) (NN inhibitor)))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT2_) (NN complex))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN cyclin-dependent-kinase) (NN inhibitor)))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN complex))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (JJ inhibitory) (NN domain)) (VP (VBD bound) (PP (TO to) (NP (NP (NP (DT the) (VBN phosphorylated) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN complex))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN angstrom))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (JJ inhibitory) (NN domain)) (VP (VBD bound) (PP (TO to) (NP (NP (NP (DT the) (VBN phosphorylated) (NN _PROT_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN complex))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN angstrom))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (JJ inhibitory) (NN domain)) (VP (VBD bound) (PP (TO to) (NP (NP (NP (DT the) (VBN phosphorylated) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN complex))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN angstrom))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_) (JJ inhibitory) (NN domain)) (VP (VBD bound) (PP (TO to) (NP (NP (NP (DT the) (VBN phosphorylated) (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN complex))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN angstrom))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_) (JJ inhibitory) (NN domain)) (VP (VBD bound) (PP (TO to) (NP (NP (NP (DT the) (VBN phosphorylated) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN complex))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN angstrom))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_) (JJ inhibitory) (NN domain)) (VP (VBD bound) (PP (TO to) (NP (NP (NP (DT the) (VBN phosphorylated) (NN _PROT_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN complex))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN angstrom))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (DT the) (NN complex)) (PP (IN as) (NP (NP (DT an) (VBN extended) (NN structure)) (VP (VBG interacting) (PP (IN with) (NP (CC both) (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (DT the) (NN complex)) (PP (IN as) (NP (NP (DT an) (VBN extended) (NN structure)) (VP (VBG interacting) (PP (IN with) (NP (CC both) (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (DT the) (NN complex)) (PP (IN as) (NP (NP (DT an) (VBN extended) (NN structure)) (VP (VBG interacting) (PP (IN with) (NP (CC both) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Cytokines) (NNS measurements)) (PP (IN during) (NP (NN _PROT1_) (NN treatment)))) (VP (VBD showed) (NP (NP (DT a) (NN trend)) (PP (TO to) (NP (NP (VBG decreasing) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))))) (PP (IN at) (NP (QP (CD 4) (, ,) (CD 12) (, ,) (CC and) (CD 24)) (NNS weeks))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD were) (ADVP (RB slightly)) (VP (VBN increased) (PP (VBG following) (NP (NP (NN _PROT2_) (NN treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.09)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (PP (IN In) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (DT a) (JJ complete) (NN response)) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD were) (ADJP (JJR higher) (PP (IN at) (NP (NP (CD 24) (NNS weeks)) (VP (VBG following) (NP (NN _PROT_) (NN treatment)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pre-treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.04)) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD decreased) (ADVP (RB markedly)) (PP (IN at) (NP (QP (CD 12) (CC and) (CD 24)) (NNS weeks))) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.02)) (, ,) (NP (NP (CD 0.03)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (. .)) (S (NP (NN mRNA) (NN expression)) (ADVP (RB positively)) (VP (VBD correlated) (PP (IN with) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN Th1/Th2) (NN type) (NNS cytokines))) (PP (IN in) (NP (DT the) (NN supernatant)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (PP (IN In) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (DT a) (JJ complete) (NN response)) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD were) (ADJP (JJR higher) (PP (IN at) (NP (NP (CD 24) (NNS weeks)) (VP (VBG following) (NP (NN _PROT2_) (NN treatment)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pre-treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.04)) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD decreased) (ADVP (RB markedly)) (PP (IN at) (NP (QP (CD 12) (CC and) (CD 24)) (NNS weeks))) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.02)) (, ,) (NP (NP (CD 0.03)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (. .)) (S (NP (NN mRNA) (NN expression)) (ADVP (RB positively)) (VP (VBD correlated) (PP (IN with) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN Th1/Th2) (NN type) (NNS cytokines))) (PP (IN in) (NP (DT the) (NN supernatant)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (PP (IN In) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (DT a) (JJ complete) (NN response)) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD were) (ADJP (JJR higher) (PP (IN at) (NP (NP (CD 24) (NNS weeks)) (VP (VBG following) (NP (NN _PROT_) (NN treatment)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pre-treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.04)) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD decreased) (ADVP (RB markedly)) (PP (IN at) (NP (QP (CD 12) (CC and) (CD 24)) (NNS weeks))) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.02)) (, ,) (NP (NP (CD 0.03)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (. .)) (S (NP (NN mRNA) (NN expression)) (ADVP (RB positively)) (VP (VBD correlated) (PP (IN with) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN Th1/Th2) (NN type) (NNS cytokines))) (PP (IN in) (NP (DT the) (NN supernatant)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (PP (IN In) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (DT a) (JJ complete) (NN response)) (PP (TO to) (NP (NN _PROT_))))))) (, ,) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD were) (ADJP (JJR higher) (PP (IN at) (NP (NP (CD 24) (NNS weeks)) (VP (VBG following) (NP (NN _PROT2_) (NN treatment)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pre-treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.04)) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD decreased) (ADVP (RB markedly)) (PP (IN at) (NP (QP (CD 12) (CC and) (CD 24)) (NNS weeks))) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.02)) (, ,) (NP (NP (CD 0.03)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (. .)) (S (NP (NN mRNA) (NN expression)) (ADVP (RB positively)) (VP (VBD correlated) (PP (IN with) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN Th1/Th2) (NN type) (NNS cytokines))) (PP (IN in) (NP (DT the) (NN supernatant)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (PP (IN In) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (DT a) (JJ complete) (NN response)) (PP (TO to) (NP (NN _PROT_))))))) (, ,) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD were) (ADJP (JJR higher) (PP (IN at) (NP (NP (CD 24) (NNS weeks)) (VP (VBG following) (NP (NN _PROT_) (NN treatment)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pre-treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.04)) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD decreased) (ADVP (RB markedly)) (PP (IN at) (NP (QP (CD 12) (CC and) (CD 24)) (NNS weeks))) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.02)) (, ,) (NP (NP (CD 0.03)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (. .)) (S (NP (NN mRNA) (NN expression)) (ADVP (RB positively)) (VP (VBD correlated) (PP (IN with) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN Th1/Th2) (NN type) (NNS cytokines))) (PP (IN in) (NP (DT the) (NN supernatant)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (PP (IN In) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (DT a) (JJ complete) (NN response)) (PP (TO to) (NP (NN _PROT_))))))) (, ,) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD were) (ADJP (JJR higher) (PP (IN at) (NP (NP (CD 24) (NNS weeks)) (VP (VBG following) (NP (NN _PROT1_) (NN treatment)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pre-treatment)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.04)) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD decreased) (ADVP (RB markedly)) (PP (IN at) (NP (QP (CD 12) (CC and) (CD 24)) (NNS weeks))) (PRN (-LRB- -LRB-) (NP (NN P) (JJ =) (CD 0.02)) (, ,) (NP (NP (CD 0.03)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (. .)) (S (NP (NN mRNA) (NN expression)) (ADVP (RB positively)) (VP (VBD correlated) (PP (IN with) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN Th1/Th2) (NN type) (NNS cytokines))) (PP (IN in) (NP (DT the) (NN supernatant)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NNS antagonists)) (VP (VB emerge) (PP (IN from) (NP (NP (NNS alterations)) (PP (IN in) (NP (NP (DT the) (JJ low-affinity) (NN binding) (NN epitope)) (PP (IN for) (NP (NN receptor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VP (VBZ induces) (NP (NP (NN bone) (NN formation)) (CC and) (NP (NN regeneration))) (PP (IN in) (NP (JJ adult) (NNS vertebrates)))) (CC and) (VP (VBZ regulates) (NP (JJ important) (JJ developmental) (NNS processes)) (PP (IN in) (NP (DT all) (NNS animals)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ homodimeric) (NN cysteine) (NN knot) (NN protein)) (SBAR (WHNP (WDT that)) (S (, ,) (PP (IN as) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (NP (DT the) (VBG _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN superfamily))))) (, ,) (VP (VBZ signals) (PP (IN by) (S (VP (VBG oligomerizing) (NP (NP (NP (NP (NN type) (CD I)) (CC and) (NP (NN type) (CD II))) (NN receptor) (NNS serine-kinases)) (PP (IN in) (NP (DT the) (NN cell) (NN membrane))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ homodimeric) (NN cysteine) (NN knot) (NN protein)) (SBAR (WHNP (WDT that)) (S (, ,) (PP (IN as) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (NP (DT the) (VBG _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN superfamily))))) (, ,) (VP (VBZ signals) (PP (IN by) (S (VP (VBG oligomerizing) (NP (NP (NP (NP (NN type) (CD I)) (CC and) (NP (NN type) (CD II))) (NN receptor) (NNS serine-kinases)) (PP (IN in) (NP (DT the) (NN cell) (NN membrane))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ homodimeric) (NN cysteine) (NN knot) (NN protein)) (SBAR (WHNP (WDT that)) (S (, ,) (PP (IN as) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (NP (DT the) (VBG _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN superfamily))))) (, ,) (VP (VBZ signals) (PP (IN by) (S (VP (VBG oligomerizing) (NP (NP (NP (NP (NN type) (CD I)) (CC and) (NP (NN type) (CD II))) (NN receptor) (NNS serine-kinases)) (PP (IN in) (NP (DT the) (NN cell) (NN membrane))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN for) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT2_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT2_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT2_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding) (NNS epitopes)) (PP (IN of) (NP (NN _PROT_))) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN type) (NN I)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (PRN (-LRB- -LRB-) (NP (NN type) (NN II)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN characterized) (S (VP (VBG using) (NP (JJ _PROT2_) (JJ mutant) (NNS proteins)) (PP (IN for) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (NNS interactions)) (PP (IN with) (NP (NN receptor) (NNS ectodomains)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ large) (NN epitope) (CD 1)) (PP (IN for) (NP (JJ high-affinity) (NN _PROT1_) (NN binding)))) (VP (VBD was) (VP (VBN detected) (S (VP (VBG spanning) (NP (NP (DT the) (NN interface)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN dimer))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Reconstitution)) (PP (IN of) (NP (NP (DT the) (JJ multiprotein) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Reconstitution)) (PP (IN of) (NP (NP (DT the) (JJ multiprotein) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Reconstitution)) (PP (IN of) (NP (NP (DT the) (JJ multiprotein) (NN complex)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))))) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NP (NN rabbit) (NN reticulocyte) (NN lysate)) (NN system)) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (VP (VBN been) (VP (VBN used) (S (VP (TO to) (VP (VB reconstitute) (NP (NP (JJ functional) (NNS complexes)) (PP (IN between) (NP (NP (NN steroid) (NNS receptors)) (CC and) (NP (NP (DT the) (JJ 90-kDa) (NN heat) (NN shock) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN used) (ADVP (RB here)) (S (VP (TO to) (VP (VB form) (NP (NP (NNS complexes)) (PP (IN between) (NP (NP (DT the) (NN _PROT2_) (NN tyrosine) (NN kinase)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NP (NN rabbit) (NN reticulocyte) (NN lysate)) (NN system)) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (VP (VBN been) (VP (VBN used) (S (VP (TO to) (VP (VB reconstitute) (NP (NP (JJ functional) (NNS complexes)) (PP (IN between) (NP (NP (NN steroid) (NNS receptors)) (CC and) (NP (NP (DT the) (JJ 90-kDa) (NN heat) (NN shock) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))))))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN used) (ADVP (RB here)) (S (VP (TO to) (VP (VB form) (NP (NP (NNS complexes)) (PP (IN between) (NP (NP (DT the) (NN _PROT_) (NN tyrosine) (NN kinase)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NP (NN rabbit) (NN reticulocyte) (NN lysate)) (NN system)) (SBAR (WHNP (WDT that)) (S (VP (VBZ has) (VP (VBN been) (VP (VBN used) (S (VP (TO to) (VP (VB reconstitute) (NP (NP (JJ functional) (NNS complexes)) (PP (IN between) (NP (NP (NN steroid) (NNS receptors)) (CC and) (NP (NP (DT the) (JJ 90-kDa) (NN heat) (NN shock) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN used) (ADVP (RB here)) (S (VP (TO to) (VP (VB form) (NP (NP (NNS complexes)) (PP (IN between) (NP (NP (DT the) (NN _PROT1_) (NN tyrosine) (NN kinase)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN Reticulocyte) (NN lysate)) (VP (VBZ forms) (NP (NP (NNS complexes)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutant)) (PP (IN of) (NP (NP (NN Rous) (NN sarcoma) (NN virus)) (NN _PROT2_))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB normally)) (ADJP (JJ present) (PP (IN in) (NP (NN cytosol))) (PP (ADVP (RB virtually) (RB entirely)) (IN in) (NP (NP (DT the) (JJ multiprotein) (NN complex)) (NN form))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN _PROT1_)) (PP (IN in) (NP (NP (DT the) (NN lysate) (NNS complexes)) (PP (IN with) (NP (JJ wild-type) (NN _PROT2_))) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (RB only) (DT a) (JJ small) (NN portion)) (VP (VBZ is) (ADVP (RB normally)) (VP (VBN recovered) (PP (PP (IN in) (NP (NP (NN cytosol)) (PP (IN in) (NP (DT the) (JJ native) (JJ multiprotein) (NN complex))))) (, ,) (CC and) (PP (IN with) (NP (NP (DT the) (JJ cellular) (NN homolog)) (, ,) (NP (NN _PROT_)) (, ,)))))))))) (SBAR (WHNP (WDT which)) (S (VP (VBZ has) (ADVP (RB never)) (VP (VBN been) (VP (VBN recovered) (PP (IN in) (NP (NN cytosol))) (PP (IN in) (NP (NP (DT the) (NN form)) (PP (IN of) (NP (NP (DT a) (JJ native) (JJ multiprotein) (NN complex)) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN _PROT1_)) (PP (IN in) (NP (NP (DT the) (NN lysate) (NNS complexes)) (PP (IN with) (NP (JJ wild-type) (NN _PROT_))) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (RB only) (DT a) (JJ small) (NN portion)) (VP (VBZ is) (ADVP (RB normally)) (VP (VBN recovered) (PP (PP (IN in) (NP (NP (NN cytosol)) (PP (IN in) (NP (DT the) (JJ native) (JJ multiprotein) (NN complex))))) (, ,) (CC and) (PP (IN with) (NP (NP (DT the) (JJ cellular) (NN homolog)) (, ,) (NP (NN _PROT2_)) (, ,)))))))))) (SBAR (WHNP (WDT which)) (S (VP (VBZ has) (ADVP (RB never)) (VP (VBN been) (VP (VBN recovered) (PP (IN in) (NP (NN cytosol))) (PP (IN in) (NP (NP (DT the) (NN form)) (PP (IN of) (NP (NP (DT a) (JJ native) (JJ multiprotein) (NN complex)) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN _PROT1_)) (PP (IN in) (NP (NP (DT the) (NN lysate) (NNS complexes)) (PP (IN with) (NP (JJ wild-type) (NN _PROT_))) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (RB only) (DT a) (JJ small) (NN portion)) (VP (VBZ is) (ADVP (RB normally)) (VP (VBN recovered) (PP (PP (IN in) (NP (NP (NN cytosol)) (PP (IN in) (NP (DT the) (JJ native) (JJ multiprotein) (NN complex))))) (, ,) (CC and) (PP (IN with) (NP (NP (DT the) (JJ cellular) (NN homolog)) (, ,) (NP (NN _PROT_)) (, ,)))))))))) (SBAR (WHNP (WDT which)) (S (VP (VBZ has) (ADVP (RB never)) (VP (VBN been) (VP (VBN recovered) (PP (IN in) (NP (NN cytosol))) (PP (IN in) (NP (NP (DT the) (NN form)) (PP (IN of) (NP (NP (DT a) (JJ native) (JJ multiprotein) (NN complex)) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (DT the) (NN lysate) (NNS complexes)) (PP (IN with) (NP (JJ wild-type) (NN _PROT1_))) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (RB only) (DT a) (JJ small) (NN portion)) (VP (VBZ is) (ADVP (RB normally)) (VP (VBN recovered) (PP (PP (IN in) (NP (NP (NN cytosol)) (PP (IN in) (NP (DT the) (JJ native) (JJ multiprotein) (NN complex))))) (, ,) (CC and) (PP (IN with) (NP (NP (DT the) (JJ cellular) (NN homolog)) (, ,) (NP (NN _PROT2_)) (, ,)))))))))) (SBAR (WHNP (WDT which)) (S (VP (VBZ has) (ADVP (RB never)) (VP (VBN been) (VP (VBN recovered) (PP (IN in) (NP (NN cytosol))) (PP (IN in) (NP (NP (DT the) (NN form)) (PP (IN of) (NP (NP (DT a) (JJ native) (JJ multiprotein) (NN complex)) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (DT the) (NN lysate) (NNS complexes)) (PP (IN with) (NP (JJ wild-type) (NN _PROT1_))) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (RB only) (DT a) (JJ small) (NN portion)) (VP (VBZ is) (ADVP (RB normally)) (VP (VBN recovered) (PP (PP (IN in) (NP (NP (NN cytosol)) (PP (IN in) (NP (DT the) (JJ native) (JJ multiprotein) (NN complex))))) (, ,) (CC and) (PP (IN with) (NP (NP (DT the) (JJ cellular) (NN homolog)) (, ,) (NP (NN _PROT_)) (, ,)))))))))) (SBAR (WHNP (WDT which)) (S (VP (VBZ has) (ADVP (RB never)) (VP (VBN been) (VP (VBN recovered) (PP (IN in) (NP (NN cytosol))) (PP (IN in) (NP (NP (DT the) (NN form)) (PP (IN of) (NP (NP (DT a) (JJ native) (JJ multiprotein) (NN complex)) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN _PROT_)) (PP (IN in) (NP (NP (DT the) (NN lysate) (NNS complexes)) (PP (IN with) (NP (JJ wild-type) (NN _PROT_))) (, ,) (SBAR (WHPP (IN of) (WHNP (WDT which))) (S (NP (RB only) (DT a) (JJ small) (NN portion)) (VP (VBZ is) (ADVP (RB normally)) (VP (VBN recovered) (PP (PP (IN in) (NP (NP (NN cytosol)) (PP (IN in) (NP (DT the) (JJ native) (JJ multiprotein) (NN complex))))) (, ,) (CC and) (PP (IN with) (NP (NP (DT the) (JJ cellular) (NN homolog)) (, ,) (NP (NN _PROT1_)) (, ,)))))))))) (SBAR (WHNP (WDT which)) (S (VP (VBZ has) (ADVP (RB never)) (VP (VBN been) (VP (VBN recovered) (PP (IN in) (NP (NN cytosol))) (PP (IN in) (NP (NP (DT the) (NN form)) (PP (IN of) (NP (NP (DT a) (JJ native) (JJ multiprotein) (NN complex)) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (DT The) (ADJP (ADJP (JJ native)) (CC and) (ADJP (JJ reconstituted))) (NN _PROT1_AND_PROT2_) (NNS complexes)) (VP (VBP have) (NP (JJ similar) (JJ thermal) (NN stability)))) (CC and) (S (, ,) (PP (IN like) (NP (NN steroid) (NN receptor) (NNS heterocomplexes))) (, ,) (NP (PRP they)) (VP (VBP are) (VP (VBN stabilized) (PP (IN by) (NP (NN molybdate))))))) (. .))) |ET|
+1 |BT| (S1 (S (SBAR (IN As) (S (ADVP (RB previously)) (VP (VBN shown) (PP (IN with) (NP (NN reticulocyte) (JJ lysate-reconstituted) (NN steroid) (NN receptor) (NN heteroprotein) (NNS complexes)))))) (, ,) (NP (DT the) (JJ reconstituted) (NN _PROT1_) (JJ multiprotein) (NN complex)) (VP (VBZ contains) (NP (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN candidate)) (PP (IN for) (S (VP (VBG providing) (NP (NP (DT the) (NN protein) (NN unfoldase) (NN activity)) (VP (VBN required) (PP (IN for) (NP (NN _PROT_) (NN association)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN As) (S (ADVP (RB previously)) (VP (VBN shown) (PP (IN with) (NP (NN reticulocyte) (JJ lysate-reconstituted) (NN steroid) (NN receptor) (NN heteroprotein) (NNS complexes)))))) (, ,) (NP (DT the) (JJ reconstituted) (NN _PROT1_) (JJ multiprotein) (NN complex)) (VP (VBZ contains) (NP (NP (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN candidate)) (PP (IN for) (S (VP (VBG providing) (NP (NP (DT the) (NN protein) (NN unfoldase) (NN activity)) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN association)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN As) (S (ADVP (RB previously)) (VP (VBN shown) (PP (IN with) (NP (NN reticulocyte) (JJ lysate-reconstituted) (NN steroid) (NN receptor) (NN heteroprotein) (NNS complexes)))))) (, ,) (NP (DT the) (JJ reconstituted) (NN _PROT_) (JJ multiprotein) (NN complex)) (VP (VBZ contains) (NP (NP (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN candidate)) (PP (IN for) (S (VP (VBG providing) (NP (NP (DT the) (NN protein) (NN unfoldase) (NN activity)) (VP (VBN required) (PP (IN for) (NP (NN _PROT2_) (NN association)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Coassociation)) (PP (IN of) (NP (NP (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (JJ human) (NN T) (NNS lymphocytes))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Coassociation)) (PP (IN of) (NP (NP (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (JJ human) (NN T) (NNS lymphocytes))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Coassociation)) (PP (IN of) (NP (NP (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (JJ human) (NN T) (NNS lymphocytes))))) (. .)))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN report))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN modulation)) (PP (IN of) (NP (NP (CD _PROT1_)) (PP (IN from) (NP (NN T) (NN cell) (NN surface))))) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN 1F7)) (-RRB- -RRB-)))))) (VP (VBD led) (PP (TO to) (NP (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN zeta) (NN tyrosine) (NNS residues)))) (CC and) (NP (VBN increased) (NN _PROT_) (JJ associated) (NN p56lck) (NN tyrosine) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN report))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN modulation)) (PP (IN of) (NP (NP (CD _PROT1_)) (PP (IN from) (NP (NN T) (NN cell) (NN surface))))) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN 1F7)) (-RRB- -RRB-)))))) (VP (VBD led) (PP (TO to) (NP (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN zeta) (NN tyrosine) (NNS residues)))) (CC and) (NP (VBN increased) (NN _PROT_) (JJ associated) (NN p56lck) (NN tyrosine) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN report))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN modulation)) (PP (IN of) (NP (NP (CD _PROT1_)) (PP (IN from) (NP (NN T) (NN cell) (NN surface))))) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN 1F7)) (-RRB- -RRB-)))))) (VP (VBD led) (PP (TO to) (NP (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN zeta) (NN tyrosine) (NNS residues)))) (CC and) (NP (VBN increased) (NN _PROT2_) (JJ associated) (NN p56lck) (NN tyrosine) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN report))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN modulation)) (PP (IN of) (NP (NP (CD _PROT_)) (PP (IN from) (NP (NN T) (NN cell) (NN surface))))) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN 1F7)) (-RRB- -RRB-)))))) (VP (VBD led) (PP (TO to) (NP (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN zeta) (NN tyrosine) (NNS residues)))) (CC and) (NP (VBN increased) (NN _PROT_) (JJ associated) (NN p56lck) (NN tyrosine) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN report))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN modulation)) (PP (IN of) (NP (NP (CD _PROT_)) (PP (IN from) (NP (NN T) (NN cell) (NN surface))))) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN 1F7)) (-RRB- -RRB-)))))) (VP (VBD led) (PP (TO to) (NP (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN zeta) (NN tyrosine) (NNS residues)))) (CC and) (NP (VBN increased) (NN _PROT2_) (JJ associated) (NN p56lck) (NN tyrosine) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN report))) (, ,) (NP (PRP we)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN modulation)) (PP (IN of) (NP (NP (CD _PROT_)) (PP (IN from) (NP (NN T) (NN cell) (NN surface))))) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN 1F7)) (-RRB- -RRB-)))))) (VP (VBD led) (PP (TO to) (NP (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN zeta) (NN tyrosine) (NNS residues)))) (CC and) (NP (VBN increased) (NN _PROT2_) (JJ associated) (NN p56lck) (NN tyrosine) (NN kinase) (NN activity)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD showed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN comodulated) (PP (IN on) (NP (DT the) (NN T) (NN cell) (NN surface))) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (DT a) (JJ known) (JJ membrane-linked) (NN protein) (NN tyrosine) (NN phosphatase)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG precipitating) (NP (NN _PROT_)) (PP (IN from) (NP (NN T) (NN cell) (NNS lysates))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD showed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN comodulated) (PP (IN on) (NP (DT the) (NN T) (NN cell) (NN surface))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (JJ membrane-linked) (NN protein) (NN tyrosine) (NN phosphatase)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG precipitating) (NP (NN _PROT_)) (PP (IN from) (NP (NN T) (NN cell) (NNS lysates))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD showed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN comodulated) (PP (IN on) (NP (DT the) (NN T) (NN cell) (NN surface))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (JJ membrane-linked) (NN protein) (NN tyrosine) (NN phosphatase)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG precipitating) (NP (NN _PROT2_)) (PP (IN from) (NP (NN T) (NN cell) (NNS lysates))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD showed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN comodulated) (PP (IN on) (NP (DT the) (NN T) (NN cell) (NN surface))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ known) (JJ membrane-linked) (NN protein) (NN tyrosine) (NN phosphatase)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG precipitating) (NP (NN _PROT_)) (PP (IN from) (NP (NN T) (NN cell) (NNS lysates))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD showed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN comodulated) (PP (IN on) (NP (DT the) (NN T) (NN cell) (NN surface))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (DT a) (JJ known) (JJ membrane-linked) (NN protein) (NN tyrosine) (NN phosphatase)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG precipitating) (NP (NN _PROT2_)) (PP (IN from) (NP (NN T) (NN cell) (NNS lysates))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB further)) (VP (VBD showed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN comodulated) (PP (IN on) (NP (DT the) (NN T) (NN cell) (NN surface))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (DT a) (JJ known) (JJ membrane-linked) (NN protein) (NN tyrosine) (NN phosphatase)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG precipitating) (NP (NN _PROT2_)) (PP (IN from) (NP (NN T) (NN cell) (NNS lysates))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (ADVP (RB strongly)) (VP (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB be) (ADVP (RB closely)) (VP (VBN associated) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (NN protein) (NN tyrosine) (NN phosphatase)) (PP (IN on) (NP (NN T) (NN cell) (NN surface))))))))))) (CC and) (VP (ADVP (RB further)) (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (CD _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (VBN enhanced) (NN tyrosine) (NN kinase) (NN activity)) (, ,) (NP (NN zeta) (NN chain) (NN phosphorylation)) (, ,) (CC and) (NP (NN T) (NN cell) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (ADVP (RB strongly)) (VP (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB be) (ADVP (RB closely)) (VP (VBN associated) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN protein) (NN tyrosine) (NN phosphatase)) (PP (IN on) (NP (NN T) (NN cell) (NN surface))))))))))) (CC and) (VP (ADVP (RB further)) (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (CD _PROT2_))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (VBN enhanced) (NN tyrosine) (NN kinase) (NN activity)) (, ,) (NP (NN zeta) (NN chain) (NN phosphorylation)) (, ,) (CC and) (NP (NN T) (NN cell) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (ADVP (RB strongly)) (VP (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB be) (ADVP (RB closely)) (VP (VBN associated) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN protein) (NN tyrosine) (NN phosphatase)) (PP (IN on) (NP (NN T) (NN cell) (NN surface))))))))))) (CC and) (VP (ADVP (RB further)) (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (CD _PROT_))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ results) (PP (IN in) (NP (NP (VBN enhanced) (NN tyrosine) (NN kinase) (NN activity)) (, ,) (NP (NN zeta) (NN chain) (NN phosphorylation)) (, ,) (CC and) (NP (NN T) (NN cell) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (ADVP (RB strongly)) (VP (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB be) (ADVP (RB closely)) (VP (VBN associated) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (NN protein) (NN tyrosine) (NN phosphatase)) (PP (IN on) (NP (NN T) (NN cell) (NN surface))))))))))) (CC and) (VP (ADVP (RB further)) (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (CD _PROT2_))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (VBN enhanced) (NN tyrosine) (NN kinase) (NN activity)) (, ,) (NP (NN zeta) (NN chain) (NN phosphorylation)) (, ,) (CC and) (NP (NN T) (NN cell) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (ADVP (RB strongly)) (VP (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB be) (ADVP (RB closely)) (VP (VBN associated) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (NN protein) (NN tyrosine) (NN phosphatase)) (PP (IN on) (NP (NN T) (NN cell) (NN surface))))))))))) (CC and) (VP (ADVP (RB further)) (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (CD _PROT_))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ results) (PP (IN in) (NP (NP (VBN enhanced) (NN tyrosine) (NN kinase) (NN activity)) (, ,) (NP (NN zeta) (NN chain) (NN phosphorylation)) (, ,) (CC and) (NP (NN T) (NN cell) (NN activation)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (ADVP (RB strongly)) (VP (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB be) (ADVP (RB closely)) (VP (VBN associated) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (NN protein) (NN tyrosine) (NN phosphatase)) (PP (IN on) (NP (NN T) (NN cell) (NN surface))))))))))) (CC and) (VP (ADVP (RB further)) (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (CD _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ results) (PP (IN in) (NP (NP (VBN enhanced) (NN tyrosine) (NN kinase) (NN activity)) (, ,) (NP (NN zeta) (NN chain) (NN phosphorylation)) (, ,) (CC and) (NP (NN T) (NN cell) (NN activation)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ desmosomal) (NN component)) (VP (VBG lacking) (NP (DT a) (NN transmembrane) (NN domain)))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (DT this) (NN interaction))))) (, ,) (SBAR (IN although) (S (S (NP (JJS most) (NNS studies)) (VP (VBP have) (VP (VBN been) (VP (VBN conducted) (PP (IN with) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (ADJP (JJ few))) (CC or) (NP (DT no)) (NP (NNS desmosomes)))))))))))) (, ,) (CC and) (S (NP (NP (NNS efforts)) (VP (TO to) (VP (VB demonstrate) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NN desmoplakin)) (CC and) (NP (JJ intermediate) (NNS filaments)))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADJP (JJ successful))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ carboxy) (JJ terminal) (`` ``) (NN tail) (NN '')) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ associates) (ADVP (RB directly)) (PP (IN with) (NP (NP (DT the) (NN amino) (JJ terminal) (`` ``) (NN head) (NN '')) (PP (IN of) (NP (NP (NN type) (NN II) (JJ epidermal) (NNS keratins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VP (VBN engineered)) (CC and) (VP (VBN purified) (NP (NP (JJ recombinant) (NN _PROT1_) (NN head)) (CC and) (NP (NN _PROT2_)) (NP (NN tail))))))) (, ,) (CC and) (S (NP (PRP we)) (VP (VBP demonstrate) (NP (JJ direct) (NN interaction)) (ADVP (FW in) (FW vitro)) (PP (PP (IN by) (NP (JJ solution-binding) (NNS assays))) (CC and) (PP (IN by) (NP (NN ligand) (NN blot) (NNS assays)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT an) (JJ 18-amino) (NN acid) (NN residue) (NN stretch)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN head))) (SBAR (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (ADVP (RB only)) (IN among) (NP (NN type) (NN II) (JJ epidermal) (NNS keratins))))))) (CC and) (SBAR (WHNP (WDT that)) (S (VP (VBZ appears) (S (VP (TO to) (VP (VB play) (NP (DT some) (NN role)) (PP (IN in) (NP (NN _PROT2_) (NN tail) (NN binding)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (ADJP (RB newly) (VBN identified)) (NN member)) (PP (IN of) (NP (NP (NN tumor) (NN necrosis) (NN factor) (NN receptor) (NN superfamily)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ suppresses) (NP (JJ _PROT2_) (NN apoptosis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (: _PROT2_) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (: _PROT2_) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (: _PROT1_) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (: _PROT1_) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (: _PROT1_) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (: _PROT1_) (NP (NN _PROT1_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (: /) (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (: /) (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (: _PROT_) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (: /) (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD inhibited) (NP (NP (JJ _PROT2_) (NN cytotoxicity)) (PP (IN in) (NP (NN HT29) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (: /) (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (: /) (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_) (: /) (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (: /) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_)))) (: /) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Multiple) (NNS proteins)) (ADVP (RB physically)) (VP (VBP interact) (PP (IN with) (S (VP (VBG _PROT1_) (NP (NP (JJ Transcriptional) (NN synergy)) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Multiple) (NNS proteins)) (ADVP (RB physically)) (VP (VBP interact) (PP (IN with) (S (VP (VBG _PROT1_) (NP (NP (JJ Transcriptional) (NN synergy)) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Multiple) (NNS proteins)) (ADVP (RB physically)) (VP (VBP interact) (PP (IN with) (S (VP (VBG _PROT1_) (NP (NP (JJ Transcriptional) (NN synergy)) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Multiple) (NNS proteins)) (ADVP (RB physically)) (VP (VBP interact) (PP (IN with) (S (VP (VBG _PROT_) (NP (NP (JJ Transcriptional) (NN synergy)) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Multiple) (NNS proteins)) (ADVP (RB physically)) (VP (VBP interact) (PP (IN with) (S (VP (VBG _PROT_) (NP (NP (JJ Transcriptional) (NN synergy)) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Multiple) (NNS proteins)) (ADVP (RB physically)) (VP (VBP interact) (PP (IN with) (S (VP (VBG _PROT_) (NP (NP (JJ Transcriptional) (NN synergy)) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (VBN radiolabeled) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (DT a) (NN probe))))) (, ,) (NP (PRP we)) (VP (VP (VBD screened) (NP (DT a) (NN B) (NN cell) (NN cDNA) (NN expression) (NN library))) (CC and) (VP (VBD isolated) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NP (NNS clones)) (VP (VBG encoding) (NP (NN _PROT2_) (NN interacting) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three)) (PP (IN of) (NP (DT these) (NNS clones)))) (VP (VBP encode) (NP (NP (NN DNA) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (S (S (NP (CD one) (NN clone)) (VP (VBZ encodes) (NP (DT a) (NN chaperone) (NN protein)))) (, ,) (CC and) (S (NP (DT another) (NN clone)) (VP (VBZ encodes) (NP (DT a) (JJ multifunctional) (NN phosphatase))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three)) (PP (IN of) (NP (DT these) (NNS clones)))) (VP (VBP encode) (NP (NP (NN DNA) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,) (S (S (NP (CD one) (NN clone)) (VP (VBZ encodes) (NP (DT a) (NN chaperone) (NN protein)))) (, ,) (CC and) (S (NP (DT another) (NN clone)) (VP (VBZ encodes) (NP (DT a) (JJ multifunctional) (NN phosphatase))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three)) (PP (IN of) (NP (DT these) (NNS clones)))) (VP (VBP encode) (NP (NP (NN DNA) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,) (S (S (NP (CD one) (NN clone)) (VP (VBZ encodes) (NP (DT a) (NN chaperone) (NN protein)))) (, ,) (CC and) (S (NP (DT another) (NN clone)) (VP (VBZ encodes) (NP (DT a) (JJ multifunctional) (NN phosphatase))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN characterized) (NP (NP (DT the) (ADJP (ADJP (JJ physical)) (CC and) (ADJP (JJ functional))) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,) (NP (NP (DT a) (NP (NN leucine) (NN zipper)) (NN transcription) (NN factor)) (VP (VBN implicated) (PP (IN in) (NP (JJ inflammatory) (NNS responses))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (NN deletion)) (PP (IN of) (NP (NP (DT the) (JJ carboxyl-terminal) (CD 28) (NN amino) (NNS acids)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD disrupted) (NP (NN _PROT2_) (NN _PROT_) (JJ physical) (NN interaction))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (NN deletion)) (PP (IN of) (NP (NP (DT the) (JJ carboxyl-terminal) (CD 28) (NN amino) (NNS acids)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD disrupted) (NP (NN _PROT2_) (NN _PROT2_) (JJ physical) (NN interaction))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (NN deletion)) (PP (IN of) (NP (NP (DT the) (JJ carboxyl-terminal) (CD 28) (NN amino) (NNS acids)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBD disrupted) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (JJ physical) (NN interaction))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (JJ transient) (NN expression) (NNS assays))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (VP (MD can) (ADVP (RB functionally)) (VP (VB cooperate) (S (VP (TO to) (ADVP (RB synergistically)) (VP (VB activate) (NP (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Electrophoretic) (NN mobility) (NN shift) (NNS assays)) (VP (VBD showed) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (PP (TO to) (NP (JJ adjacent) (NN DNA) (NN binding) (NNS sites)))))) (, ,) (CC but) (S (ADVP (RB apparently)) (VP (VBP do) (RB not) (VP (VB influence) (NP (NP (DT the) (NP (NP (NN kinetics)) (CC or) (NP (NN affinity)))) (PP (IN of) (NP (NP (DT each) (JJ other) (POS 's)) (NN DNA) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN association)) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC or) (NP (NP (PRP$ its) (NNS relatives)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN association)) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (PRP$ its) (NNS relatives)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN association)) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (PRP$ its) (NNS relatives)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN association)) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC or) (NP (NP (PRP$ its) (NNS relatives)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN association)) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC or) (NP (NP (PRP$ its) (NNS relatives)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN association)) (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC or) (NP (NP (PRP$ its) (NNS relatives)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (JJ first) (NN cDNA)) (PP (IN from) (NP (DT the) (NN _PROT1_) (NN family))) (S (VP (TO to) (VP (VB be) (VP (VBN cloned)))))) (VP (VBD was) (VP (VBN designated) (S (NP (NN _PROT2_)))))) (, ,) (CC and) (S (NP (JJ multiple) (NN _PROT_) (NN family) (NNS members)) (VP (VBP have) (ADVP (RB now)) (VP (VBN been) (VP (VBN identified)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (JJ first) (NN cDNA)) (PP (IN from) (NP (DT the) (NN _PROT1_) (NN family))) (S (VP (TO to) (VP (VB be) (VP (VBN cloned)))))) (VP (VBD was) (VP (VBN designated) (S (NP (NN _PROT_)))))) (, ,) (CC and) (S (NP (JJ multiple) (NN _PROT2_) (NN family) (NNS members)) (VP (VBP have) (ADVP (RB now)) (VP (VBN been) (VP (VBN identified)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (JJ first) (NN cDNA)) (PP (IN from) (NP (DT the) (NN _PROT_) (NN family))) (S (VP (TO to) (VP (VB be) (VP (VBN cloned)))))) (VP (VBD was) (VP (VBN designated) (S (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (JJ multiple) (NN _PROT2_) (NN family) (NNS members)) (VP (VBP have) (ADVP (RB now)) (VP (VBN been) (VP (VBN identified)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN DP)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NNS polypeptides)) (PP (IN with) (NP (NP (QP (IN at) (JJS least) (CD two)) (NNS members)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT all) (NN _PROT_) (NN family) (NNS members))) (ADVP (FW in) (FW vivo)))) (, ,) (CC and) (S (NP (DT each) (NN complex)) (VP (VBZ is) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG activating) (NP (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT all) (NN _PROT2_) (NN family) (NNS members))) (ADVP (FW in) (FW vivo)))) (, ,) (CC and) (S (NP (DT each) (NN complex)) (VP (VBZ is) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG activating) (NP (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CC Both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT all) (NN _PROT2_) (NN family) (NNS members))) (ADVP (FW in) (FW vivo)))) (, ,) (CC and) (S (NP (DT each) (NN complex)) (VP (VBZ is) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG activating) (NP (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT1_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT1_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT1_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT1_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT1_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN subunit))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ various) (NN _PROT_) (NNS complexes)) (VP (VBP display) (NP (NP (JJ strong) (NNS differences)) (PP (IN in) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))))))))) (, ,) (CC and) (S (NP (NP (DT the) (NN specificity)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)) (NP (NN binding))))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN subunit))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Two) (ADJP (ADJP (JJ distinct)) (CC and) (ADJP (JJ independent))) (NNS sites)) (PP (IN on) (NP (NN _PROT1_)))) (VP (VBP trigger) (NP (NP (NN _PROT2_) (CD _PROT2_) (NN dimer) (NN formation)) (CC and) (NP (NN signalling))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (JJ helical) (NN cytokine) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CD _PROT1_)) (CC and) (NP (PRP$ its) (JJ specific) (NN binding) (NN subunit) (NN _PROT2_) (NN _PROT2_))) (VP (VBP form) (NP (NP (DT a) (JJ 1:1) (NN complex)) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN by) (S (VP (VBG promoting) (NP (NP (NN homodimerization)) (PP (IN of) (NP (DT the) (NN signalling) (NN subunit) (NN _PROT_)))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN target) (NNS cells)))))))) (, ,) (VP (VBZ triggers) (NP (JJ intracellular) (NNS responses)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (JJ helical) (NN cytokine) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CD _PROT1_)) (CC and) (NP (PRP$ its) (JJ specific) (NN binding) (NN subunit) (NN _PROT_) (NN _PROT_))) (VP (VBP form) (NP (NP (DT a) (JJ 1:1) (NN complex)) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN by) (S (VP (VBG promoting) (NP (NP (NN homodimerization)) (PP (IN of) (NP (DT the) (NN signalling) (NN subunit) (NN _PROT2_)))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN target) (NNS cells)))))))) (, ,) (VP (VBZ triggers) (NP (JJ intracellular) (NNS responses)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (JJ helical) (NN cytokine) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CD _PROT_)) (CC and) (NP (PRP$ its) (JJ specific) (NN binding) (NN subunit) (NN _PROT1_) (NN _PROT1_))) (VP (VBP form) (NP (NP (DT a) (JJ 1:1) (NN complex)) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN by) (S (VP (VBG promoting) (NP (NP (NN homodimerization)) (PP (IN of) (NP (DT the) (NN signalling) (NN subunit) (NN _PROT2_)))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN target) (NNS cells)))))))) (, ,) (VP (VBZ triggers) (NP (JJ intracellular) (NNS responses)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD expressed) (NP (NP (ADJP (RB differently) (VBN tagged)) (NNS forms)) (PP (IN of) (NP (NN _PROT1_))))) (CC and) (VP (VBD used) (NP (PRP them)) (PP (IN in) (NP (NP (JJ solution-phase) (NN binding) (NNS assays)) (VP (TO to) (VP (VB show) (SBAR (IN that) (S (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NNS domains)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBP undergo) (NP (NN dimerization)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NNS membranes))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (ADVP (RB here)) (SBAR (IN that) (S (S (NP (NP (DT both) (NP (DT the) (NP (NN site) (CD 2)) (CC and) (NP (NN site) (CD 3))) (NN _PROT1_) (NNS variants)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))))) (VP (VP (VBP bind) (NP (DT a) (JJ single) (NN _PROT_) (NN molecule))) (CC but) (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB dimerize) (NP (PRP it))))))))) (, ,) (IN whereas) (S (NP (DT the) (JJ combined) (NN site) (CD 2/3) (NNS variants)) (VP (VB lose) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (ADVP (RB here)) (SBAR (IN that) (S (S (NP (NP (DT both) (NP (DT the) (NP (NN site) (CD 2)) (CC and) (NP (NN site) (CD 3))) (NN _PROT1_) (NNS variants)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))))) (VP (VP (VBP bind) (NP (DT a) (JJ single) (NN _PROT2_) (NN molecule))) (CC but) (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB dimerize) (NP (PRP it))))))))) (, ,) (IN whereas) (S (NP (DT the) (JJ combined) (NN site) (CD 2/3) (NNS variants)) (VP (VB lose) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (ADVP (RB here)) (SBAR (IN that) (S (S (NP (NP (DT both) (NP (DT the) (NP (NN site) (CD 2)) (CC and) (NP (NN site) (CD 3))) (NN _PROT1_) (NNS variants)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))))) (VP (VP (VBP bind) (NP (DT a) (JJ single) (NN _PROT_) (NN molecule))) (CC but) (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB dimerize) (NP (PRP it))))))))) (, ,) (IN whereas) (S (NP (DT the) (JJ combined) (NN site) (CD 2/3) (NNS variants)) (VP (VB lose) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (ADVP (RB here)) (SBAR (IN that) (S (S (NP (NP (DT both) (NP (DT the) (NP (NN site) (CD 2)) (CC and) (NP (NN site) (CD 3))) (NN _PROT_) (NNS variants)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VP (VBP bind) (NP (DT a) (JJ single) (NN _PROT2_) (NN molecule))) (CC but) (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB dimerize) (NP (PRP it))))))))) (, ,) (IN whereas) (S (NP (DT the) (JJ combined) (NN site) (CD 2/3) (NNS variants)) (VP (VB lose) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (ADVP (RB here)) (SBAR (IN that) (S (S (NP (NP (DT both) (NP (DT the) (NP (NN site) (CD 2)) (CC and) (NP (NN site) (CD 3))) (NN _PROT_) (NNS variants)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))))) (VP (VP (VBP bind) (NP (DT a) (JJ single) (NN _PROT_) (NN molecule))) (CC but) (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB dimerize) (NP (PRP it))))))))) (, ,) (IN whereas) (S (NP (DT the) (JJ combined) (NN site) (CD 2/3) (NNS variants)) (VP (VB lose) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (ADVP (RB here)) (SBAR (IN that) (S (S (NP (NP (DT both) (NP (DT the) (NP (NN site) (CD 2)) (CC and) (NP (NN site) (CD 3))) (NN _PROT_) (NNS variants)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))))) (VP (VP (VBP bind) (NP (DT a) (JJ single) (NN _PROT1_) (NN molecule))) (CC but) (VP (VBP are) (ADJP (JJ unable) (S (VP (TO to) (VP (VB dimerize) (NP (PRP it))))))))) (, ,) (IN whereas) (S (NP (DT the) (JJ combined) (NN site) (CD 2/3) (NNS variants)) (VP (VB lose) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN binding) (NNS properties)) (PP (IN of) (NP (DT these) (NNS variants))) (ADVP (FW in) (FW vitro))) (, ,) (CC and) (NP (NP (DT the) (NN result)) (PP (IN of) (S (VP (VBG using) (NP (NP (DT a) (VBG neutralizing) (JJ monoclonal) (NN antibody)) (VP (VBN directed) (PP (IN against) (NP (NN site) (CD 3))))))))) (, ,)) (VP (VBP lead) (PP (TO to) (NP (DT the) (NN conclusion) (SBAR (IN that) (S (NP (NN _PROT1_) (NN dimer)) (VP (VBZ is) (VP (VBN formed) (PP (IN through) (NP (NP (JJ direct) (NN binding)) (PP (IN at) (NP (NP (CD two) (ADJP (ADJP (JJ independent)) (CC and) (ADJP (RB differently) (VBN oriented))) (NNS sites)) (PP (IN on) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS experiments)) (ADVP (RB further)) (VP (VBP reveal) (SBAR (IN that) (S (NP (DT the) (ADJP (RB fully) (VBN assembled)) (NN receptor) (NN complex)) (VP (VBZ is) (VP (VBN composed) (PP (IN of) (NP (CD two) (NN _PROT1_) (, ,) (CD two) (NN _PROT2_) (NN _PROT2_) (CC and) (CD two) (NN _PROT_) (NNS molecules))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS experiments)) (ADVP (RB further)) (VP (VBP reveal) (SBAR (IN that) (S (NP (DT the) (ADJP (RB fully) (VBN assembled)) (NN receptor) (NN complex)) (VP (VBZ is) (VP (VBN composed) (PP (IN of) (NP (CD two) (NN _PROT1_) (, ,) (CD two) (NN _PROT_) (NN _PROT_) (CC and) (CD two) (NN _PROT2_) (NNS molecules))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS experiments)) (ADVP (RB further)) (VP (VBP reveal) (SBAR (IN that) (S (NP (DT the) (ADJP (RB fully) (VBN assembled)) (NN receptor) (NN complex)) (VP (VBZ is) (VP (VBN composed) (PP (IN of) (NP (CD two) (NN _PROT_) (, ,) (CD two) (NN _PROT1_) (NN _PROT1_) (CC and) (CD two) (NN _PROT2_) (NNS molecules))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN spleen) (NN tyrosine) (NN kinase)) (NP (NN _PROT1_))) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN Src-family) (NN kinase) (NN _PROT2_)) (CC and) (NP (DT a) (JJ _PROT_) (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN spleen) (NN tyrosine) (NN kinase)) (NP (NN _PROT1_))) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN Src-family) (NN kinase) (NN _PROT2_)) (CC and) (NP (DT a) (JJ _PROT_) (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN spleen) (NN tyrosine) (NN kinase)) (NP (NN _PROT1_))) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN Src-family) (NN kinase) (NN _PROT_)) (CC and) (NP (DT a) (JJ _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN spleen) (NN tyrosine) (NN kinase)) (NP (NN _PROT_))) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN Src-family) (NN kinase) (NN _PROT1_AND_PROT2_)) (CC and) (NP (DT a) (JJ _PROT_) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN spleen) (NN tyrosine) (NN kinase)) (NP (NN _PROT_))) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN Src-family) (NN kinase) (NN _PROT1_)) (CC and) (NP (DT a) (JJ _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN spleen) (NN tyrosine) (NN kinase)) (NP (NN _PROT_))) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN Src-family) (NN kinase) (NN _PROT1_)) (CC and) (NP (DT a) (JJ _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 72-kDa) (NN spleen) (NN tyrosine) (NN kinase) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NN Src-family) (NN kinase) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP contribute) (PP (TO to) (NP (NP (NN signaling)) (PP (IN via) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor) (NN complex))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 72-kDa) (NN spleen) (NN tyrosine) (NN kinase) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NN Src-family) (NN kinase) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP contribute) (PP (TO to) (NP (NP (NN signaling)) (PP (IN via) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor) (NN complex))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 72-kDa) (NN spleen) (NN tyrosine) (NN kinase) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NN Src-family) (NN kinase) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP contribute) (PP (TO to) (NP (NP (NN signaling)) (PP (IN via) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor) (NN complex))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 72-kDa) (NN spleen) (NN tyrosine) (NN kinase) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN Src-family) (NN kinase) (NN _PROT1_AND_PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))) (VP (VBP contribute) (PP (TO to) (NP (NP (NN signaling)) (PP (IN via) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor) (NN complex))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 72-kDa) (NN spleen) (NN tyrosine) (NN kinase) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN Src-family) (NN kinase) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP contribute) (PP (TO to) (NP (NP (NN signaling)) (PP (IN via) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor) (NN complex))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 72-kDa) (NN spleen) (NN tyrosine) (NN kinase) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN Src-family) (NN kinase) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))) (VP (VBP contribute) (PP (TO to) (NP (NP (NN signaling)) (PP (IN via) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor) (NN complex))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN from) (NP (JJ human) (NN B) (NNS lymphocytes)))) (VP (MD can) (VP (VB interact) (ADVP (RB directly)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD coimmunoprecipitated) (PP (IN from) (NP (ADJP (ADJP (JJ mature)) (CC and) (ADJP (JJ activated))) (NN B-cell) (NNS lines))))) (, ,) (CC and) (S (NP (NP (JJ gel-purified) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD reassociated) (PP (IN in) (NP (FW vitro))) (, ,) (S (VP (VBG demonstrating) (NP (PRP$ their) (JJ direct) (NN interaction))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD coimmunoprecipitated) (PP (IN from) (NP (ADJP (ADJP (JJ mature)) (CC and) (ADJP (JJ activated))) (NN B-cell) (NNS lines))))) (, ,) (CC and) (S (NP (NP (JJ gel-purified) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBD reassociated) (PP (IN in) (NP (FW vitro))) (, ,) (S (VP (VBG demonstrating) (NP (PRP$ their) (JJ direct) (NN interaction))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD coimmunoprecipitated) (PP (IN from) (NP (ADJP (ADJP (JJ mature)) (CC and) (ADJP (JJ activated))) (NN B-cell) (NNS lines))))) (, ,) (CC and) (S (NP (NP (JJ gel-purified) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBD reassociated) (PP (IN in) (NP (FW vitro))) (, ,) (S (VP (VBG demonstrating) (NP (PRP$ their) (JJ direct) (NN interaction))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD coimmunoprecipitated) (PP (IN from) (NP (ADJP (ADJP (JJ mature)) (CC and) (ADJP (JJ activated))) (NN B-cell) (NNS lines))))) (, ,) (CC and) (S (NP (NP (JJ gel-purified) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBD reassociated) (PP (IN in) (NP (FW vitro))) (, ,) (S (VP (VBG demonstrating) (NP (PRP$ their) (JJ direct) (NN interaction))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD coimmunoprecipitated) (PP (IN from) (NP (ADJP (ADJP (JJ mature)) (CC and) (ADJP (JJ activated))) (NN B-cell) (NNS lines))))) (, ,) (CC and) (S (NP (NP (JJ gel-purified) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBD reassociated) (PP (IN in) (NP (FW vitro))) (, ,) (S (VP (VBG demonstrating) (NP (PRP$ their) (JJ direct) (NN interaction))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD coimmunoprecipitated) (PP (IN from) (NP (ADJP (ADJP (JJ mature)) (CC and) (ADJP (JJ activated))) (NN B-cell) (NNS lines))))) (, ,) (CC and) (S (NP (NP (JJ gel-purified) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD reassociated) (PP (IN in) (NP (FW vitro))) (, ,) (S (VP (VBG demonstrating) (NP (PRP$ their) (JJ direct) (NN interaction))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_AND_PROT2_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT2_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT2_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT2_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT2_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT2_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT2_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT1_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN _PROT_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT1_AND_PROT2_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT1_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT2_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT1_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT1_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT2_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT1_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN _PROT_) (NN interaction)) (VP (MD may) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN stage)) (PP (IN of) (NP (NN B-cell) (NN differentiation)))))) (, ,) (SBAR (IN since) (S (S (NP (NN _PROT_) (NNS associations)) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN pre-B)) (CC and) (NP (NN myeloma) (NN cell) (NNS lines))))))) (CC and) (S (NP (NP (NN _PROT1_)) (PP (IN from) (NP (DT an) (JJ immature) (NN B-cell) (NN line)))) (VP (VBD did) (RB not) (VP (VB reassociate) (PP (IN with) (NP (NN _PROT2_))) (ADVP (FW in) (FW vitro)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Crosslinking)) (PP (IN of) (NP (NN cell) (NN surface) (NP (NN IgM))))) (VP (VBD led) (PP (TO to) (NP (NP (JJ rapid) (NN activation)) (PP (IN of) (NP (NP (DT both) (NP (NN tyrosine) (CC and) (NN serine/threonine) (NN protein) (NN kinase)) (NNS activities)) (SBAR (WHNP (WDT that)) (S (VP (VBD resulted) (PP (IN in) (NP (NN phosphorylation))) (ADVP (FW in) (FW vitro))))))) (PP (IN of) (NP (NP (NNS proteins)) (ADJP (JJ coprecipitating) (PP (IN with) (NP (NP (NN _PROT1_) (JJ particular)) (, ,) (NP (NP (DT a) (NN serine/threonine) (JJ phosphorylated) (NN protein) (CD 120) (NN kDa)) (PP (IN in) (NP (NP (NN size)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Several) (NNS phosphoproteins)) (, ,) (PP (VBG including) (NP (NP (NP (CD one)) (PP (IN of) (NP (CD 72) (NN kDa)))) (CC and) (NP (NP (CD one)) (PP (IN of) (NP (CD 120) (NN kDa)))))) (, ,)) (VP (VBD coprecipitated) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Sequential) (NN immunoprecipitation)) (VP (VBD identified) (NP (NP (DT the) (JJ 72-kDa) (NN protein)) (VP (VBN associated) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))))) (PP (IN as) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 120-kDa) (NN serine/threonine) (JJ phosphorylated) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBD coprecipitated) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))))))) (VP (VBD resembled) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (PP (IN by) (NP (JJ several) (NNS criteria)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 120-kDa) (NN serine/threonine) (JJ phosphorylated) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBD coprecipitated) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_))))))) (VP (VBD resembled) (NP (NP (DT the) (JJ _PROT_) (NN _PROT2_)) (PP (IN by) (NP (JJ several) (NNS criteria)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ 120-kDa) (NN serine/threonine) (JJ phosphorylated) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBD coprecipitated) (PP (IN with) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_))))))) (VP (VBD resembled) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT2_)) (PP (IN by) (NP (JJ several) (NNS criteria)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (NN link)) (PP (IN between) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_))) (, ,) (NP (NP (NN coupling)) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor)) (PP (TO to) (NP (DT the) (NN phosphatidylinositol) (NN pathway))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (NN link)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))) (, ,) (NP (NP (NN coupling)) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor)) (PP (TO to) (NP (DT the) (NN phosphatidylinositol) (NN pathway))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (NN link)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))) (, ,) (NP (NP (NN coupling)) (NP (DT the) (NN B-cell) (NN antigen) (NN receptor)) (PP (TO to) (NP (DT the) (NN phosphatidylinositol) (NN pathway))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN transglutaminase)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,))) (PP (TO to) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (NN identity)) (PP (IN of) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_)))))))))) (VP (VBP remain) (ADJP (JJ unknown)))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB identify) (NP (JJ specific) (JJ _PROT1_) (NNS interactions))))) (, ,) (NP (NP (DT a) (JJ recombinant) (NN fusion) (NN protein)) (NP (NN affinity) (NN reagent))) (VP (VBD was) (VP (VP (VBN constructed)) (CC and) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS proteins)) (VP (VBG associating) (PP (IN with) (NP (NN _PROT2_))) (PP (IN from) (NP (NP (JJ human) (NN platelet) (NNS lysates)) (CC and) (NP (NN erythroleukemia) (NNS cells))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Immunoblotting) (NNS studies)) (VP (VBD were) (VP (VBN used) (S (VP (TO to) (VP (VB confirm) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN from) (NP (JJ fresh) (NN platelet) (NNS lysates))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN fusion) (NN protein)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD was) (VP (VBN shown) (S (VP (VP (TO to) (VP (VBP coprecipitate) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NN immunoprecipitation) (NNS studies))))) (CC and) (VP (TO to) (VP (VB colocalize) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN immunofluorescence) (NNS studies)) (PP (IN of) (NP (JJ intact) (JJ glass-activated) (NNS platelets)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD was) (VP (VBN shown) (S (VP (VP (TO to) (VP (VBP coprecipitate) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NN immunoprecipitation) (NNS studies))))) (CC and) (VP (TO to) (VP (VB colocalize) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN immunofluorescence) (NNS studies)) (PP (IN of) (NP (JJ intact) (JJ glass-activated) (NNS platelets)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBD was) (VP (VBN shown) (S (VP (VP (TO to) (VP (VBP coprecipitate) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (NN immunoprecipitation) (NNS studies))))) (CC and) (VP (TO to) (VP (VB colocalize) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN immunofluorescence) (NNS studies)) (PP (IN of) (NP (JJ intact) (JJ glass-activated) (NNS platelets)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS data)) (ADVP (RB thus)) (VP (VP (VBP demonstrate) (NP (NP (JJ specific) (NN binding)) (PP (IN of) (NP (NN platelet) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB participate) (PP (IN in) (NP (NP (DT the) (NP (JJ cellular) (NN localization)) (CC and/or) (NP (JJ enzymatic) (NN regulation))) (PP (IN of) (NP (NN platelet) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS data)) (ADVP (RB thus)) (VP (VP (VBP demonstrate) (NP (NP (JJ specific) (NN binding)) (PP (IN of) (NP (NN platelet) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD may) (VP (VB participate) (PP (IN in) (NP (NP (DT the) (NP (JJ cellular) (NN localization)) (CC and/or) (NP (JJ enzymatic) (NN regulation))) (PP (IN of) (NP (NN platelet) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS data)) (ADVP (RB thus)) (VP (VP (VBP demonstrate) (NP (NP (JJ specific) (NN binding)) (PP (IN of) (NP (NN platelet) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB participate) (PP (IN in) (NP (NP (DT the) (NP (JJ cellular) (NN localization)) (CC and/or) (NP (JJ enzymatic) (NN regulation))) (PP (IN of) (NP (NN platelet) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS data)) (ADVP (RB thus)) (VP (VP (VBP demonstrate) (NP (NP (JJ specific) (NN binding)) (PP (IN of) (NP (NN platelet) (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD may) (VP (VB participate) (PP (IN in) (NP (NP (DT the) (NP (JJ cellular) (NN localization)) (CC and/or) (NP (JJ enzymatic) (NN regulation))) (PP (IN of) (NP (NN platelet) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS data)) (ADVP (RB thus)) (VP (VP (VBP demonstrate) (NP (NP (JJ specific) (NN binding)) (PP (IN of) (NP (NN platelet) (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB participate) (PP (IN in) (NP (NP (DT the) (NP (JJ cellular) (NN localization)) (CC and/or) (NP (JJ enzymatic) (NN regulation))) (PP (IN of) (NP (NN platelet) (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS data)) (ADVP (RB thus)) (VP (VP (VBP demonstrate) (NP (NP (JJ specific) (NN binding)) (PP (IN of) (NP (NN platelet) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB participate) (PP (IN in) (NP (NP (DT the) (NP (JJ cellular) (NN localization)) (CC and/or) (NP (JJ enzymatic) (NN regulation))) (PP (IN of) (NP (NN platelet) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN X-ray) (NN structure)) (PP (IN of) (NP (DT a) (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN receptor) (NN complex))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ human) (NN pituitary) (NNS hormones)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP regulate) (NP (NP (DT a) (JJ large) (NN variety)) (PP (IN of) (NP (JJ physiological) (NNS processes))) (, ,) (SBAR (WHPP (IN among) (WHNP (WDT which))) (S (VP (VBP are) (NP (NP (NP (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN of) (NP (NP (NN muscle)) (, ,) (NP (NP (NP (NN bone)) (CC and) (NP (NN cartilage))) (NNS cells)) (, ,) (CC and) (NP (NN lactation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ human) (NN pituitary) (NNS hormones)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP regulate) (NP (NP (DT a) (JJ large) (NN variety)) (PP (IN of) (NP (JJ physiological) (NNS processes))) (, ,) (SBAR (WHPP (IN among) (WHNP (WDT which))) (S (VP (VBP are) (NP (NP (NP (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN of) (NP (NP (NN muscle)) (, ,) (NP (NP (NP (NN bone)) (CC and) (NP (NN cartilage))) (NNS cells)) (, ,) (CC and) (NP (NN lactation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ human) (NN pituitary) (NNS hormones)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP regulate) (NP (NP (DT a) (JJ large) (NN variety)) (PP (IN of) (NP (JJ physiological) (NNS processes))) (, ,) (SBAR (WHPP (IN among) (WHNP (WDT which))) (S (VP (VBP are) (NP (NP (NP (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN of) (NP (NP (NN muscle)) (, ,) (NP (NP (NP (NN bone)) (CC and) (NP (NN cartilage))) (NNS cells)) (, ,) (CC and) (NP (NN lactation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ human) (NN pituitary) (NNS hormones)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP regulate) (NP (NP (DT a) (JJ large) (NN variety)) (PP (IN of) (NP (JJ physiological) (NNS processes))) (, ,) (SBAR (WHPP (IN among) (WHNP (WDT which))) (S (VP (VBP are) (NP (NP (NP (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN of) (NP (NP (NN muscle)) (, ,) (NP (NP (NP (NN bone)) (CC and) (NP (NN cartilage))) (NNS cells)) (, ,) (CC and) (NP (NN lactation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ human) (NN pituitary) (NNS hormones)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP regulate) (NP (NP (DT a) (JJ large) (NN variety)) (PP (IN of) (NP (JJ physiological) (NNS processes))) (, ,) (SBAR (WHPP (IN among) (WHNP (WDT which))) (S (VP (VBP are) (NP (NP (NP (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN of) (NP (NP (NN muscle)) (, ,) (NP (NP (NP (NN bone)) (CC and) (NP (NN cartilage))) (NNS cells)) (, ,) (CC and) (NP (NN lactation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ human) (NN pituitary) (NNS hormones)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP regulate) (NP (NP (DT a) (JJ large) (NN variety)) (PP (IN of) (NP (JJ physiological) (NNS processes))) (, ,) (SBAR (WHPP (IN among) (WHNP (WDT which))) (S (VP (VBP are) (NP (NP (NP (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN of) (NP (NP (NN muscle)) (, ,) (NP (NP (NP (NN bone)) (CC and) (NP (NN cartilage))) (NNS cells)) (, ,) (CC and) (NP (NN lactation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (VP (VBP are) (NP (NP (NN single-pass) (NN transmembrane) (NNS receptors)) (PP (IN from) (NP (NP (NN class) (CD 1)) (PP (IN of) (NP (DT the) (JJ haematopoietic) (NN receptor) (NN superfamily)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (VP (VBP are) (NP (NP (NN single-pass) (NN transmembrane) (NNS receptors)) (PP (IN from) (NP (NP (NN class) (CD 1)) (PP (IN of) (NP (DT the) (JJ haematopoietic) (NN receptor) (NN superfamily)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (VP (VBP are) (NP (NP (NN single-pass) (NN transmembrane) (NNS receptors)) (PP (IN from) (NP (NP (NN class) (CD 1)) (PP (IN of) (NP (DT the) (JJ haematopoietic) (NN receptor) (NN superfamily)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (VP (VBP are) (NP (NP (NN single-pass) (NN transmembrane) (NNS receptors)) (PP (IN from) (NP (NP (NN class) (CD 1)) (PP (IN of) (NP (DT the) (JJ haematopoietic) (NN receptor) (NN superfamily)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (VP (VBP are) (NP (NP (NN single-pass) (NN transmembrane) (NNS receptors)) (PP (IN from) (NP (NP (NN class) (CD 1)) (PP (IN of) (NP (DT the) (JJ haematopoietic) (NN receptor) (NN superfamily)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (VP (VBP are) (NP (NP (NN single-pass) (NN transmembrane) (NNS receptors)) (PP (IN from) (NP (NP (NN class) (CD 1)) (PP (IN of) (NP (DT the) (JJ haematopoietic) (NN receptor) (NN superfamily)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT2_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT2_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT1_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT1_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT2_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT1_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT1_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT1_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT2_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBP overlap))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBP overlap))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NN activation)) (VP (VBZ involves) (NP (NN receptor) (NN homodimerization)) (PP (IN in) (NP (DT a) (JJ sequential) (NN process))))) (: :) (S (NP (NP (DT the) (JJ active) (JJ ternary) (NN complex)) (VP (VBG containing) (NP (NP (CD one) (NN ligand)) (CC and) (NP (CD two) (NN receptor) (NNS molecules))))) (VP (VBZ is) (VP (VBN formed) (PP (IN by) (S (S (NP (NP (NN association)) (PP (IN of) (NP (DT a) (NN receptor) (NN molecule))) (PP (TO to) (NP (DT an) (JJ intermediate) (NN 1:1) (NN complex.) (NN _PROT_)))) (VP (VBZ does) (RB not) (VP (VB bind) (PP (TO to) (NP (DT the) (NN _PROT_) (NN receptor)))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBZ binds) (PP (TO to) (NP (CC both) (DT the) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))))) (, ,) (CC and) (S (NP (NN mutagenesis) (NNS studies)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ receptor-binding) (NNS sites)) (PP (IN on) (NP (NN _PROT2_)))) (VP (VBP overlap))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP present) (ADVP (RB here)) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 1:1) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Comparisons)) (PP (IN with) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN complex)))) (VP (VBP reveal) (SBAR (WHADVP (WRB how)) (S (NP (NN _PROT_)) (VP (MD can) (VP (VB bind) (PP (TO to) (NP (DT the) (CD two) (ADJP (RB distinctly) (JJ different)) (NN receptor) (NN binding) (NNS surfaces))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Comparisons)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex)))) (VP (VBP reveal) (SBAR (WHADVP (WRB how)) (S (NP (NN _PROT2_)) (VP (MD can) (VP (VB bind) (PP (TO to) (NP (DT the) (CD two) (ADJP (RB distinctly) (JJ different)) (NN receptor) (NN binding) (NNS surfaces))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Comparisons)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex)))) (VP (VBP reveal) (SBAR (WHADVP (WRB how)) (S (NP (NN _PROT2_)) (VP (MD can) (VP (VB bind) (PP (TO to) (NP (DT the) (CD two) (ADJP (RB distinctly) (JJ different)) (NN receptor) (NN binding) (NNS surfaces))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ _PROT1_) (NP (NP (DT an) (JJ Ala-->Gly) (NN substitution)) (PP (IN in) (NP (NP (NN helix) (CD 1)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN repeat) (CD 17))))) (SBAR (WHNP (WDT that)) (S (ADVP (RB severely)) (VP (VBZ disrupts) (NP (NP (DT the) (NP (NN structure)) (CC and) (NP (NN self-association))) (PP (IN of) (NP (DT the) (NN erythrocyte) (NN spectrin) (NN heterodimer))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN self-association) (NN site)) (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (VP (VBN formed) (PP (IN by) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (NNS helices) (CD 1) (CC and) (CD 2)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN repeat) (CD 17)) (PP (IN of) (NP (NP (CD one) (NN dimer)) (PP (IN with) (NP (NP (NN helix) (CD 3)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN repeat) (CD 1)) (PP (IN of) (NP (DT the) (JJ other) (NN dimer))) (S (VP (TO to) (VP (VB form) (NP (CD two) (JJ combined) (NN alpha-beta) (JJ triple-helical) (NNS segments)))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NP (NN linkage) (NNS studies)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (ADJP (RBS most) (JJ consistent) (PP (IN with) (NP (DT a) (NN _PROT1_) (NN _PROT1_) (NN gene) (NN mutation))))))))) (, ,) (NP (DT a) (NN nucleotide) (NN change)) (VP (VBD was) (VP (VBN identified) (PP (IN in) (NP (NN codon) (CD 2018))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (DT an) (JJ Ala-->Gly) (NN substitution)) (PP (IN in) (NP (NP (DT the) (JJ first) (JJ helical) (NN domain)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NP (NN repeat) (CD 17))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Involvement)) (PP (IN of) (NP (NN _PROT1_) (NN signal) (NN transducer) (NN _PROT2_))) (PP (IN in) (NP (JJ _PROT_) (NN signal) (NN transduction))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Involvement)) (PP (IN of) (NP (NN _PROT1_) (NN signal) (NN transducer) (NN _PROT_))) (PP (IN in) (NP (JJ _PROT2_) (NN signal) (NN transduction))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Involvement)) (PP (IN of) (NP (NN _PROT_) (NN signal) (NN transducer) (NN _PROT1_))) (PP (IN in) (NP (JJ _PROT2_) (NN signal) (NN transduction))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN cytokine)) (PP (IN with) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (NP (NNS biofunctions)) (SBAR (WHNP (WDT which)) (S (VP (VBP overlap) (PP (IN with) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NN _PROT1_) (JJ specific) (NN binding) (NN protein)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN cell) (NNS lines))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (NNS similarities)) (PP (IN in) (NP (NNS biofunctions)))) (CC and) (NP (NP (NNS differences)) (PP (IN in) (NP (NN ligand) (NN binding) (NNS proteins))))) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD prompted) (S (NP (PRP us)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ shares) (NP (JJ common) (NN signal) (NN transduction) (NNS mechanisms)) (PP (IN with) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (NNS similarities)) (PP (IN in) (NP (NNS biofunctions)))) (CC and) (NP (NP (NNS differences)) (PP (IN in) (NP (NN ligand) (NN binding) (NNS proteins))))) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD prompted) (S (NP (PRP us)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NN _PROT2_)) (VP (VBZ shares) (NP (JJ common) (NN signal) (NN transduction) (NNS mechanisms)) (PP (IN with) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (NNS similarities)) (PP (IN in) (NP (NNS biofunctions)))) (CC and) (NP (NP (NNS differences)) (PP (IN in) (NP (NN ligand) (NN binding) (NNS proteins))))) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD prompted) (S (NP (PRP us)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ shares) (NP (JJ common) (NN signal) (NN transduction) (NNS mechanisms)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (NNS similarities)) (PP (IN in) (NP (NNS biofunctions)))) (CC and) (NP (NP (NNS differences)) (PP (IN in) (NP (NN ligand) (NN binding) (NNS proteins))))) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD prompted) (S (NP (PRP us)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NN _PROT2_)) (VP (VBZ shares) (NP (JJ common) (NN signal) (NN transduction) (NNS mechanisms)) (PP (IN with) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (NNS similarities)) (PP (IN in) (NP (NNS biofunctions)))) (CC and) (NP (NP (NNS differences)) (PP (IN in) (NP (NN ligand) (NN binding) (NNS proteins))))) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD prompted) (S (NP (PRP us)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ shares) (NP (JJ common) (NN signal) (NN transduction) (NNS mechanisms)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (DT The) (NNS similarities)) (PP (IN in) (NP (NNS biofunctions)))) (CC and) (NP (NP (NNS differences)) (PP (IN in) (NP (NN ligand) (NN binding) (NNS proteins))))) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD prompted) (S (NP (PRP us)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ shares) (NP (JJ common) (NN signal) (NN transduction) (NNS mechanisms)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN examined) (NP (NP (JJ early) (NNS signals)) (VP (VBN triggered) (PP (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT a) (JJ multifactor-dependent) (JJ human) (JJ erythroleukemic) (NN cell) (NN line)) (, ,) (NP (NN TF-1))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD can) (ADVP (DT both)) (VP (VP (VB stimulate) (NP (NN cell) (NN proliferation))) (, ,) (VP (VB induce) (NP (NP (JJ similar) (NN pattern)) (PP (IN of) (NP (NN protein) (NN tyrosine) (NN phosphorylation))))) (, ,) (CC and) (VP (VB activate) (NP (NP (DT the) (JJ same) (NN proto-oncogene) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN expression)) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (MD can) (ADVP (DT both)) (VP (VP (VB stimulate) (NP (NN cell) (NN proliferation))) (, ,) (VP (VB induce) (NP (NP (JJ similar) (NN pattern)) (PP (IN of) (NP (NN protein) (NN tyrosine) (NN phosphorylation))))) (, ,) (CC and) (VP (VB activate) (NP (NP (DT the) (JJ same) (NN proto-oncogene) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN expression)) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (MD can) (ADVP (DT both)) (VP (VP (VB stimulate) (NP (NN cell) (NN proliferation))) (, ,) (VP (VB induce) (NP (NP (JJ similar) (NN pattern)) (PP (IN of) (NP (NN protein) (NN tyrosine) (NN phosphorylation))))) (, ,) (CC and) (VP (VB activate) (NP (NP (DT the) (JJ same) (NN proto-oncogene) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN expression)) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP share) (NP (JJ similar) (JJ early) (NN signaling) (NNS events)) (PP (IN with) (NP (NP (DT the) (NN possibility)) (PP (IN of) (S (VP (VBG using) (NP (NP (DT the) (JJ same) (NN signal) (NN transducer)) (, ,) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP share) (NP (JJ similar) (JJ early) (NN signaling) (NNS events)) (PP (IN with) (NP (NP (DT the) (NN possibility)) (PP (IN of) (S (VP (VBG using) (NP (NP (DT the) (JJ same) (NN signal) (NN transducer)) (, ,) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP imply) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP share) (NP (JJ similar) (JJ early) (NN signaling) (NNS events)) (PP (IN with) (NP (NP (DT the) (NN possibility)) (PP (IN of) (S (VP (VBG using) (NP (NP (DT the) (JJ same) (NN signal) (NN transducer)) (, ,) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB next)) (VP (VBD tested) (SBAR (IN whether) (S (NP (ADJP (NN _PROT1_) (JJ induced)) (NN signaling)) (VP (MD can) (VP (VB be) (VP (VBN inhibited) (PP (IN by) (NP (NP (JJ _PROT2_) (NNS antibodies)) (SBAR (WHNP (WDT which)) (S (VP (VBD blocked) (NP (JJ _PROT_) (NNS functions)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB next)) (VP (VBD tested) (SBAR (IN whether) (S (NP (ADJP (NN _PROT1_) (JJ induced)) (NN signaling)) (VP (MD can) (VP (VB be) (VP (VBN inhibited) (PP (IN by) (NP (NP (JJ _PROT_) (NNS antibodies)) (SBAR (WHNP (WDT which)) (S (VP (VBD blocked) (NP (JJ _PROT2_) (NNS functions)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB next)) (VP (VBD tested) (SBAR (IN whether) (S (NP (ADJP (NN _PROT_) (JJ induced)) (NN signaling)) (VP (MD can) (VP (VB be) (VP (VBN inhibited) (PP (IN by) (NP (NP (JJ _PROT1_) (NNS antibodies)) (SBAR (WHNP (WDT which)) (S (VP (VBD blocked) (NP (JJ _PROT2_) (NNS functions)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (NP (JJ _PROT1_) (NNS antibodies)) (VP (VBD abolished) (NP (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NN protein) (NN tyrosine) (NN phosphorylation)) (, ,) (CC and) (NP (NN _PROT2_) (NN gene) (NN expression))) (VP (VBN elicited) (PP (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (NP (JJ _PROT1_) (NNS antibodies)) (VP (VBD abolished) (NP (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NN protein) (NN tyrosine) (NN phosphorylation)) (, ,) (CC and) (NP (NN _PROT_) (NN gene) (NN expression))) (VP (VBN elicited) (PP (IN by) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (NP (JJ _PROT1_) (NNS antibodies)) (VP (VBD abolished) (NP (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NN protein) (NN tyrosine) (NN phosphorylation)) (, ,) (CC and) (NP (NN _PROT_) (NN gene) (NN expression))) (VP (VBN elicited) (PP (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (NP (JJ _PROT_) (NNS antibodies)) (VP (VBD abolished) (NP (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NN protein) (NN tyrosine) (NN phosphorylation)) (, ,) (CC and) (NP (NN _PROT1_) (NN gene) (NN expression))) (VP (VBN elicited) (PP (IN by) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (NP (JJ _PROT_) (NNS antibodies)) (VP (VBD abolished) (NP (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NN protein) (NN tyrosine) (NN phosphorylation)) (, ,) (CC and) (NP (NN _PROT1_) (NN gene) (NN expression))) (VP (VBN elicited) (PP (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (NP (JJ _PROT_) (NNS antibodies)) (VP (VBD abolished) (NP (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NN protein) (NN tyrosine) (NN phosphorylation)) (, ,) (CC and) (NP (NN _PROT_) (NN gene) (NN expression))) (VP (VBN elicited) (PP (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN TF-1) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (NN _PROT1_) (NN antibody)) (VP (VBD inhibited) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,))) (S (VP (TO to) (VP (VB transduce) (NP (NP (JJ early) (NNS signals)) (PP (IN in) (NP (NN TF-1) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (NN _PROT1_) (NN antibody)) (VP (VBD inhibited) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,))) (S (VP (TO to) (VP (VB transduce) (NP (NP (JJ early) (NNS signals)) (PP (IN in) (NP (NN TF-1) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (NN _PROT_) (NN antibody)) (VP (VBD inhibited) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,))) (S (VP (TO to) (VP (VB transduce) (NP (NP (JJ early) (NNS signals)) (PP (IN in) (NP (NN TF-1) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VP (VBP utilize) (NP (JJ different) (NN ligand) (NN binding) (NNS proteins))) (, ,) (CC but) (VP (VBP share) (NP (NP (NP (JJ common) (NN signal) (NN transducer)) (, ,) (NP (NN _PROT_)) (, ,)) (PP (IN in) (NP (NN TF-1) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VP (VBP utilize) (NP (JJ different) (NN ligand) (NN binding) (NNS proteins))) (, ,) (CC but) (VP (VBP share) (NP (NP (NP (JJ common) (NN signal) (NN transducer)) (, ,) (NP (NN _PROT2_)) (, ,)) (PP (IN in) (NP (NN TF-1) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VP (VBP utilize) (NP (JJ different) (NN ligand) (NN binding) (NNS proteins))) (, ,) (CC but) (VP (VBP share) (NP (NP (NP (JJ common) (NN signal) (NN transducer)) (, ,) (NP (NN _PROT2_)) (, ,)) (PP (IN in) (NP (NN TF-1) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NP (DT a) (JJ specific) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (NN binding) (NN protein)) (ADJP (RB structurally) (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN alpha) (NN chain)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NP (DT a) (JJ specific) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (NN binding) (NN protein)) (ADJP (RB structurally) (JJ related) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN alpha) (NN chain)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NP (DT a) (JJ specific) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (NN binding) (NN protein)) (ADJP (RB structurally) (JJ related) (PP (TO to) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN alpha) (NN chain)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN cytokine)) (VP (VBN secreted) (PP (IN by) (NP (VBN activated) (NN T) (NNS lymphocytes)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (NP (ADJP (JJ many))) (, ,) (CONJP (CC but) (RB not)) (NP (DT all)) (, ,) (NP (JJ biological) (NNS activities))) (PP (IN with) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN cytokine)) (VP (VBN secreted) (PP (IN by) (NP (VBN activated) (NN T) (NNS lymphocytes)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (NP (ADJP (JJ many))) (, ,) (CONJP (CC but) (RB not)) (NP (DT all)) (, ,) (NP (JJ biological) (NNS activities))) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN cytokine)) (VP (VBN secreted) (PP (IN by) (NP (VBN activated) (NN T) (NNS lymphocytes)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ shares) (NP (NP (ADJP (JJ many))) (, ,) (CONJP (CC but) (RB not)) (NP (DT all)) (, ,) (NP (JJ biological) (NNS activities))) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD Two) (NNS proteins)) (VP (VBP have) (VP (VBN been) (VP (VBN described) (PP (IN as) (NP (NP (NNS constituents)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN receptor)) (, ,) (NP (NP (NP (DT a) (ADJP (RB approximately) (JJ 140-kDa)) (NN glycoprotein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (DT the) (NN gamma) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN gammac)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))))))))))) (, ,) (CC but) (S (NP (NP (DT neither)) (PP (IN of) (NP (DT these) (NNS proteins)))) (VP (VBZ binds) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (DT a) (NN cDNA)) (VP (VBG encoding) (NP (NP (NP (DT an) (NN _PROT1_) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN from) (NP (DT the) (NN Caki-1) (JJ human) (JJ renal) (NN carcinoma) (NN cell) (NN line))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_)) (VP (VBZ shows) (NP (NP (NN homology)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN receptor)))) (, ,) (CC and) (PP (TO to) (NP (DT a) (JJR lesser) (NN extent))) (, ,) (PP (IN with) (NP (DT the) (NN prolactin) (NN receptor))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN cDNA))))) (VP (VP (VBP bind) (NP (NN _PROT2_)) (PP (IN with) (NP (JJ high) (NN affinity)))) (CC but) (VP (VBP do) (RB not) (VP (VB bind) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN cDNA))))) (VP (VP (VBP bind) (NP (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))) (CC but) (VP (VBP do) (RB not) (VP (VB bind) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (DT the) (NN _PROT_) (NN cDNA))))) (VP (VP (VBP bind) (NP (NN _PROT1_)) (PP (IN with) (NP (JJ high) (NN affinity)))) (CC but) (VP (VBP do) (RB not) (VP (VB bind) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN co-transfected) (PP (IN with) (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_) (NN cDNA)) (CC and) (NP (NN _PROT2_) (NN cDNA))))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN reconstitution)) (PP (IN of) (NP (NP (DT a) (JJ small) (NN number)) (PP (IN of) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBD recognized) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN co-transfected) (PP (IN with) (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_) (NN cDNA)) (CC and) (NP (NN _PROT_) (NN cDNA))))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN reconstitution)) (PP (IN of) (NP (NP (DT a) (JJ small) (NN number)) (PP (IN of) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBD recognized) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN co-transfected) (PP (IN with) (NP (DT the) (VBN cloned) (NP (NP (NN _PROT1_) (NN cDNA)) (CC and) (NP (NN _PROT_) (NN cDNA))))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN reconstitution)) (PP (IN of) (NP (NP (DT a) (JJ small) (NN number)) (PP (IN of) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBD recognized) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN co-transfected) (PP (IN with) (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_) (NN cDNA)) (CC and) (NP (NN _PROT1_) (NN cDNA))))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN reconstitution)) (PP (IN of) (NP (NP (DT a) (JJ small) (NN number)) (PP (IN of) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBD recognized) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN co-transfected) (PP (IN with) (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_) (NN cDNA)) (CC and) (NP (NN _PROT1_) (NN cDNA))))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN reconstitution)) (PP (IN of) (NP (NP (DT a) (JJ small) (NN number)) (PP (IN of) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBD recognized) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN COS-7) (NNS cells)) (VP (VBN co-transfected) (PP (IN with) (NP (DT the) (VBN cloned) (NP (NP (NN _PROT_) (NN cDNA)) (CC and) (NP (NN _PROT_) (NN cDNA))))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN reconstitution)) (PP (IN of) (NP (NP (DT a) (JJ small) (NN number)) (PP (IN of) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBD recognized) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN interaction)) (PP (IN of) (NP (JJ primary) (NN HIV-1) (NN _PROT2_) (NNS glycoproteins))) (PP (IN with) (NP (DT the) (NN chemokine) (NN receptor) (NN _PROT_))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN interaction)) (PP (IN of) (NP (JJ primary) (NN HIV-1) (NN _PROT_) (NNS glycoproteins))) (PP (IN with) (NP (DT the) (NN chemokine) (NN receptor) (NN _PROT2_))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ _PROT_) (NN interaction)) (PP (IN of) (NP (JJ primary) (NN HIV-1) (NN _PROT1_) (NNS glycoproteins))) (PP (IN with) (NP (DT the) (NN chemokine) (NN receptor) (NN _PROT2_))) (. .)))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (NP (JJ efficient) (NN entry)) (PP (IN into) (NP (NN target) (NNS cells))))) (, ,) (NP (NP (JJ primary) (ADJP (ADJP (JJ macrophage-tropic)) (CC and) (ADJP (JJ laboratory-adapted))) (JJ human) (NN immunodeficiency) (NNS viruses)) (NP (NP (NN type) (CD 1)) (PRN (-LRB- -LRB-) (NP (NN HIV-1)) (-RRB- -RRB-)))) (VP (VBP require) (NP (NP (NP (JJ particular) (NN chemokine) (NNS receptors)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (, ,) (ADVP (RB respectively)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ primary) (NN receptor) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (NP (CD 1-6))) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (NP (JJ efficient) (NN entry)) (PP (IN into) (NP (NN target) (NNS cells))))) (, ,) (NP (NP (JJ primary) (ADJP (ADJP (JJ macrophage-tropic)) (CC and) (ADJP (JJ laboratory-adapted))) (JJ human) (NN immunodeficiency) (NNS viruses)) (NP (NP (NN type) (CD 1)) (PRN (-LRB- -LRB-) (NP (NN HIV-1)) (-RRB- -RRB-)))) (VP (VBP require) (NP (NP (NP (JJ particular) (NN chemokine) (NNS receptors)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (, ,) (ADVP (RB respectively)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ primary) (NN receptor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (NP (CD 1-6))) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (NP (JJ efficient) (NN entry)) (PP (IN into) (NP (NN target) (NNS cells))))) (, ,) (NP (NP (JJ primary) (ADJP (ADJP (JJ macrophage-tropic)) (CC and) (ADJP (JJ laboratory-adapted))) (JJ human) (NN immunodeficiency) (NNS viruses)) (NP (NP (NN type) (CD 1)) (PRN (-LRB- -LRB-) (NP (NN HIV-1)) (-RRB- -RRB-)))) (VP (VBP require) (NP (NP (NP (JJ particular) (NN chemokine) (NNS receptors)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (, ,) (ADVP (RB respectively)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ primary) (NN receptor) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (NP (CD 1-6))) (-RRB- -RRB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT2_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT2_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT2_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT1_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT2_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT1_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT2_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT1_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT1_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT1_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT2_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT1_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT1_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT1_) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT1_) (NNS ligands)) (, ,) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (DT the) (JJ exterior) (NN envelope) (NN glycoprotein)) (, ,) (PP (IN of) (NP (JJ macrophage-tropic) (JJ primary) (NN HIV-1)))) (CC and) (NP (JJ soluble) (NN _PROT_))))) (VP (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ inhibits) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (JJ natural) (NN _PROT_) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (QP (CD 7) (, ,) (CD 8))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ apparent) (NN affinity)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (VP (VBD was) (ADJP (RB dramatically) (JJR lower)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ soluble) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ apparent) (NN affinity)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (VP (VBD was) (ADJP (RB dramatically) (JJR lower)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ soluble) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ apparent) (NN affinity)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (VP (VBD was) (ADJP (RB dramatically) (JJR lower)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ soluble) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Additionally)) (, ,) (PP (IN in) (DT the) (NN absence) (IN of) (NP (NN _PROT1_))) (, ,) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (DT a) (JJ two-domain) (NN _PROT2_) (NN fragment)) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Additionally)) (, ,) (PP (IN in) (DT the) (NN absence) (IN of) (NP (NN _PROT1_))) (, ,) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (DT a) (JJ two-domain) (NN _PROT_) (NN fragment)) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Additionally)) (, ,) (PP (IN in) (DT the) (NN absence) (IN of) (NP (NN _PROT_))) (, ,) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (DT a) (JJ two-domain) (NN _PROT1_) (NN fragment)) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN _PROT1_) (NN fragment)) (VP (VBG retaining) (NP (NP (DT the) (JJ _PROT2_) (NN site)) (CC and) (NP (JJ overlapping) (NNS epitopes))))) (VP (VBD was) (ADJP (JJ able) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))) (SBAR (RB only) (IN if) (S (NP (NP (DT the) (JJ V3) (NN loop)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB specify) (NP (NP (NN HIV-1) (NN tropism)) (CC and) (NP (NN chemokine) (NN receptor) (NN choice))))))) (, ,)) (VP (VBD was) (ADVP (RB also)) (ADJP (JJ present) (PP (IN on) (NP (DT the) (NN molecule))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN _PROT1_) (NN fragment)) (VP (VBG retaining) (NP (NP (DT the) (JJ _PROT_) (NN site)) (CC and) (NP (JJ overlapping) (NNS epitopes))))) (VP (VBD was) (ADJP (JJ able) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (SBAR (RB only) (IN if) (S (NP (NP (DT the) (JJ V3) (NN loop)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB specify) (NP (NP (NN HIV-1) (NN tropism)) (CC and) (NP (NN chemokine) (NN receptor) (NN choice))))))) (, ,)) (VP (VBD was) (ADVP (RB also)) (ADJP (JJ present) (PP (IN on) (NP (DT the) (NN molecule))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN _PROT_) (NN fragment)) (VP (VBG retaining) (NP (NP (DT the) (JJ _PROT1_) (NN site)) (CC and) (NP (JJ overlapping) (NNS epitopes))))) (VP (VBD was) (ADJP (JJ able) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (SBAR (RB only) (IN if) (S (NP (NP (DT the) (JJ V3) (NN loop)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB specify) (NP (NP (NN HIV-1) (NN tropism)) (CC and) (NP (NN chemokine) (NN receptor) (NN choice))))))) (, ,)) (VP (VBD was) (ADVP (RB also)) (ADJP (JJ present) (PP (IN on) (NP (DT the) (NN molecule))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT1_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT2_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT_) (NNS complexes))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT1_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT2_) (NNS complexes))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT1_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT2_) (NNS complexes))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT1_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT_) (NNS complexes))) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT1_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT2_) (NNS complexes))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT1_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT2_) (NNS complexes))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT1_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT_) (NNS complexes))) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT1_AND_PROT2_) (NNS complexes))) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT1_) (NNS complexes))) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Neutralizing) (NNS antibodies)) (VP (VBN directed) (PP (IN against) (NP (NP (UCP (CC either) (ADJP (JJ _PROT_)) (CC or) (NP (NN V3))) (NNS epitopes)) (PP (IN on) (NP (NN _PROT_))))))) (VP (VBD blocked) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (JJ _PROT1_) (NNS complexes))) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN HIV-1) (NN attachment)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VBZ creates) (NP (NP (DT a) (JJ high-affinity) (NN binding) (NN site)) (PP (IN for) (NP (NN _PROT2_)))) (, ,) (S (VP (VBG leading) (PP (TO to) (NP (NP (NN membrane) (NN fusion)) (CC and) (NP (NN virus) (NN entry))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_)))) (: :) (NP (NP (NP (NN binding)) (CC and) (NP (NN inhibition))) (PP (IN of) (NP (NN amyloid) (NN formation)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Aggregated) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ key) (NN component)) (PP (IN of) (NP (NP (DT the) (JJ amyloid) (NNS depositions)) (VP (VBN found) (PP (IN in) (NP (NP (DT the) (NNS brains)) (PP (IN of) (NP (NP (NNS patients)) (PP (IN with) (NP (NN Alzheimer) (POS 's) (NN disease))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN analysis)) (PP (IN of) (NP (NP (NNS complexes)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN with) (NP (NP (NN CSF) (NNS proteins)) (PP (IN in) (NP (DT a) (NN KBr) (NN gradient)))))))) (VP (VBD revealed) (NP (NP (DT an) (NN association)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (PP (RB only) (IN with) (NP (JJ free) (NNS proteins))) (CC and) (PP (RB not) (IN with) (NP (NN lipoprotein) (NNS particles))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (JJ second) (JJ major) (NN CSF) (NN protein)) (, ,)) (VP (VP (VBD formed) (NP (NP (JJ SDS-stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))))) (CC and) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NP (DT the) (NN rate)) (PP (IN of) (NP (DT _PROT_) (NN _PROT_) (NN fibril) (NN formation)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (JJ second) (JJ major) (NN CSF) (NN protein)) (, ,)) (VP (VP (VBD formed) (NP (NP (JJ SDS-stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NP (DT the) (NN rate)) (PP (IN of) (NP (DT _PROT_) (NN _PROT_) (NN fibril) (NN formation)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (JJ second) (JJ major) (NN CSF) (NN protein)) (, ,)) (VP (VP (VBD formed) (NP (NP (JJ SDS-stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))))) (CC and) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NP (DT the) (NN rate)) (PP (IN of) (NP (DT _PROT2_) (NN _PROT2_) (NN fibril) (NN formation)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (JJ second) (JJ major) (NN CSF) (NN protein)) (, ,)) (VP (VP (VBD formed) (NP (NP (JJ SDS-stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NP (DT the) (NN rate)) (PP (IN of) (NP (DT _PROT_) (NN _PROT_) (NN fibril) (NN formation)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (JJ second) (JJ major) (NN CSF) (NN protein)) (, ,)) (VP (VP (VBD formed) (NP (NP (JJ SDS-stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))))) (CC and) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NP (DT the) (NN rate)) (PP (IN of) (NP (DT _PROT2_) (NN _PROT2_) (NN fibril) (NN formation)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (JJ second) (JJ major) (NN CSF) (NN protein)) (, ,)) (VP (VP (VBD formed) (NP (NP (JJ SDS-stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))))) (CC and) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NP (DT the) (NN rate)) (PP (IN of) (NP (DT _PROT2_) (NN _PROT2_) (NN fibril) (NN formation)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ physiological) (NNS buffers)) (CC and) (NP (NN CSF)))) (, ,) (NP (NN _PROT1_)) (ADVP (RB exclusively)) (VP (VBD decreased) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NNS pentamers)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Endogenous) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NNS complexes)) (VP (VBD were) (VP (VBN detected) (PP (IN in) (NP (JJ human) (NN CSF))) (PP (IN by) (NP (NN immunoprecipitation)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (JJ site-directed) (NN mutagenesis)) (CC and) (NP (JJ computer-assisted) (NN modelling))))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN monomer))))) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (DT _PROT1_) (NN _PROT1_) (NN binding) (NNS proteins)) (VP (VP (VBP play) (NP (DT a) (JJ key) (NN role)) (PP (IN in) (NP (NP (DT the) (NN modulation)) (PP (IN of) (NP (DT _PROT2_) (NN _PROT2_) (NN aggregation)))))) (CC and) (ADVP (RB normally)) (VP (VBP prevent) (NP (NN amyloid) (NN formation)) (PP (PP (IN in) (NP (JJ biological) (NNS fluids))) (CC and) (PP (IN in) (NP (DT the) (NN brain))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Proto-oncoprotein) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (VBN activated) (NNS thymocytes)) (CC and) (NP (JJ peripheral) (NN T) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT2_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT2_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT1_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT1_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT2_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT1_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT1_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT1_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ molecular) (NN adapter) (NN _PROT_)) (VP (VP (VBZ is) (ADVP (RB rapidly)) (ADJP (NN tyrosine) (JJ phosphorylated)) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))) (CC and) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_) (NN homology) (NN domain-2) (-LRB- -LRB-) (NN SH2) (-RRB- -RRB-) (NN /SH3) (JJ domain-containing) (NNS adapters)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP interact) (PP (IN with) (NP (NP (NN guanine) (NN nucleotide) (NN exchange) (NNS factors)) (ADJP (JJ specific) (PP (IN for) (NP (DT the) (NN Ras) (NN family)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB link) (NP (NN _PROT2_) (NN activation)) (PP (TO to) (NP (NP (NNS molecules)) (SBAR (WHNP (WDT that)) (S (VP (VBP regulate) (NP (NN GTP) (NN binding) (NNS proteins))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ SH2/SH3-containing) (NN protein) (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ contains) (NP (NP (DT a) (JJ guanine) (NN nucleotide) (NN exchange) (NN factor)) (NN domain)))) (, ,) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (DT a) (JJ crucial) (NN role)) (PP (IN in) (NP (NP (NN thymocyte) (NN development)) (CC and) (NP (NP (NN activation)) (PP (IN of) (NP (JJ peripheral) (NN T) (NNS cells))) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ SH2/SH3-containing) (NN protein) (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ contains) (NP (NP (DT a) (JJ guanine) (NN nucleotide) (NN exchange) (NN factor)) (NN domain)))) (, ,) (CC and) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (DT a) (JJ crucial) (NN role)) (PP (IN in) (NP (NP (NN thymocyte) (NN development)) (CC and) (NP (NP (NN activation)) (PP (IN of) (NP (JJ peripheral) (NN T) (NNS cells))) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ SH2/SH3-containing) (NN protein) (NN _PROT_)) (ADVP (RB also)) (VP (VBZ contains) (NP (NP (DT a) (JJ guanine) (NN nucleotide) (NN exchange) (NN factor)) (NN domain)))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (DT a) (JJ crucial) (NN role)) (PP (IN in) (NP (NP (NN thymocyte) (NN development)) (CC and) (NP (NP (NN activation)) (PP (IN of) (NP (JJ peripheral) (NN T) (NNS cells))) (PP (VBG following) (NP (NP (NN stimulation)) (PP (IN through) (NP (DT the) (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP form) (NP (NP (JJ inducible) (JJ molecular) (NNS complexes)) (PP (IN in) (NP (NP (JJ _PROT_) (NN murine) (NNS thymocytes)) (CC and) (NP (JJ peripheral) (NN T) (NNS cells)) (CONJP (RB as) (RB well) (IN as)) (NP (JJ pervanadate-treated) (NN T) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP form) (NP (NP (JJ inducible) (JJ molecular) (NNS complexes)) (PP (IN in) (NP (NP (JJ _PROT2_) (NN murine) (NNS thymocytes)) (CC and) (NP (JJ peripheral) (NN T) (NNS cells)) (CONJP (RB as) (RB well) (IN as)) (NP (JJ pervanadate-treated) (NN T) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP form) (NP (NP (JJ inducible) (JJ molecular) (NNS complexes)) (PP (IN in) (NP (NP (JJ _PROT2_) (NN murine) (NNS thymocytes)) (CC and) (NP (JJ peripheral) (NN T) (NNS cells)) (CONJP (RB as) (RB well) (IN as)) (NP (JJ pervanadate-treated) (NN T) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_AND_PROT2_) (NNS interactions)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ detectable) (PP (IN in) (NP (NP (ADJP (RB freshly) (VBN isolated)) (NN T) (NNS cells)) (PP (IN from) (NP (NP (JJ gene-targeted) (NNS mice)) (SBAR (WHNP (WDT that)) (S (VP (VBP lack) (NP (NP (DT the) (ADJP (NN T) (JJ cell-specific)) (JJ inhibitory) (NN receptor) (NN _PROT_)) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN hyperphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NNS interactions)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ detectable) (PP (IN in) (NP (NP (ADJP (RB freshly) (VBN isolated)) (NN T) (NNS cells)) (PP (IN from) (NP (NP (JJ gene-targeted) (NNS mice)) (SBAR (WHNP (WDT that)) (S (VP (VBP lack) (NP (NP (DT the) (ADJP (NN T) (JJ cell-specific)) (JJ inhibitory) (NN receptor) (NN _PROT2_)) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN hyperphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NNS interactions)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ detectable) (PP (IN in) (NP (NP (ADJP (RB freshly) (VBN isolated)) (NN T) (NNS cells)) (PP (IN from) (NP (NP (JJ gene-targeted) (NNS mice)) (SBAR (WHNP (WDT that)) (S (VP (VBP lack) (NP (NP (DT the) (ADJP (NN T) (JJ cell-specific)) (JJ inhibitory) (NN receptor) (NN _PROT_)) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN hyperphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NNS interactions)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ detectable) (PP (IN in) (NP (NP (ADJP (RB freshly) (VBN isolated)) (NN T) (NNS cells)) (PP (IN from) (NP (NP (JJ gene-targeted) (NNS mice)) (SBAR (WHNP (WDT that)) (S (VP (VBP lack) (NP (NP (DT the) (ADJP (NN T) (JJ cell-specific)) (JJ inhibitory) (NN receptor) (NN _PROT2_)) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN hyperphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NNS interactions)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ detectable) (PP (IN in) (NP (NP (ADJP (RB freshly) (VBN isolated)) (NN T) (NNS cells)) (PP (IN from) (NP (NP (JJ gene-targeted) (NNS mice)) (SBAR (WHNP (WDT that)) (S (VP (VBP lack) (NP (NP (DT the) (ADJP (NN T) (JJ cell-specific)) (JJ inhibitory) (NN receptor) (NN _PROT_)) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN hyperphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NNS interactions)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ detectable) (PP (IN in) (NP (NP (ADJP (RB freshly) (VBN isolated)) (NN T) (NNS cells)) (PP (IN from) (NP (NP (JJ gene-targeted) (NNS mice)) (SBAR (WHNP (WDT that)) (S (VP (VBP lack) (NP (NP (DT the) (ADJP (NN T) (JJ cell-specific)) (JJ inhibitory) (NN receptor) (NN _PROT1_)) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN hyperphosphorylated) (PP (IN on) (NP (NN tyrosine) (NNS residues)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VP (VBZ is) (ADVP (RB directly)) (VP (VBN mediated) (PP (IN via) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADVP (RB directly)) (VP (VBN mediated) (PP (IN via) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADVP (RB directly)) (VP (VBN mediated) (PP (IN via) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VP (VBZ is) (ADVP (RB directly)) (VP (VBN mediated) (PP (IN via) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VP (VBZ is) (ADVP (RB directly)) (VP (VBN mediated) (PP (IN via) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADVP (RB directly)) (VP (VBN mediated) (PP (IN via) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))))) (CC and) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (VBN conserved) (NN motif) (NN Y699) (NN MTP) (NN present)) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBZ is) (NP (NP (DT the) (VBG binding) (NN site)) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN SH2) (NN domain)))) (ADVP (FW in) (FW vitro)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP imply) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ molecular) (NN adapter)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NNS thymocytes)) (CC and) (NP (JJ peripheral) (NN T) (NNS cells)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN hematopoietin)) (ADJP (JJ important) (PP (IN for) (NP (NP (NP (NN megakaryocyte) (NN proliferation)) (CC and) (NP (NN production))) (PP (IN of) (NP (NN blood) (NNS platelets))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD sought) (S (VP (TO to) (VP (VB characterize) (SBAR (WHADVP (WRB how)) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds)) (CC and) (VP (VBZ activates) (NP (NP (PRP$ its) (NN receptor)) (, ,) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT1_) (NN domain)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN TPO1-153)) (-RRB- -RRB-))))) (VP (VBZ has) (VP (VBN been) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN coat) (NN protein)) (PP (IN of) (NP (NN M13) (NN bacteriophage))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT1_) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN TPO1-153)) (-RRB- -RRB-))))) (VP (VBZ has) (VP (VBN been) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN coat) (NN protein)) (PP (IN of) (NP (NN M13) (NN bacteriophage))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT_) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN TPO1-153)) (-RRB- -RRB-))))) (VP (VBZ has) (VP (VBN been) (VP (VBN fused) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN coat) (NN protein)) (PP (IN of) (NP (NN M13) (NN bacteriophage))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Phage) (JJ enzyme-linked) (JJ immunosorbent) (NN assay)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB determine) (NP (NP (NNS affinities)) (PP (IN for) (NP (NP (NN binding)) (PP (TO to) (NP (CC both) (NP (DT the) (NN _PROT1_) (NN receptor)) (CC and) (NP (CD five) (NN _PROT2_) (JJ monoclonal) (NNS antibodies))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (DT the) (JJ other) (CD three) (JJ monoclonal) (NNS antibodies)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBD were) (ADJP (JJ effective)) (PP (IN at) (S (VP (VBG blocking) (NP (NN _PROT1_) (NN activity)))))) (CC but) (VP (VBD did) (RB not) (VP (VB block) (NP (NP (JJ initial) (NN binding)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (PRP$ its) (NN receptor))))))))) (, ,)) (VP (VBD had) (NP (NP (NNS epitopes)) (ADVP (RB predominantly))) (PP (IN on) (NP (NP (NN helix)) (CC or) (NP (CD 3)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NP (CD two) (JJ distinct) (JJ receptor-binding) (NNS sites)) (SBAR (WHNP (WDT that)) (S (VP (VBP function) (S (VP (TO to) (VP (VB dimerize) (NP (NN _PROT2_) (NNS receptors)) (PP (IN in) (NP (DT a) (JJ sequential) (NN fashion))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT1_) (NN proto-oncogene)))) (VP (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (JJ several) (NNS proteins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))))))) (, ,) (CC and) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB regulate) (NP (NN signalling)) (PP (IN by) (NP (JJ many) (NN cell) (NN surface) (NNS receptors)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT1_) (NN proto-oncogene)))) (VP (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (JJ several) (NNS proteins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))))))) (, ,) (CC and) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB regulate) (NP (NN signalling)) (PP (IN by) (NP (JJ many) (NN cell) (NN surface) (NNS receptors)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT1_) (NN proto-oncogene)))) (VP (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (JJ several) (NNS proteins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (, ,) (CC and) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB regulate) (NP (NN signalling)) (PP (IN by) (NP (JJ many) (NN cell) (NN surface) (NNS receptors)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT_) (NN proto-oncogene)))) (VP (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (JJ several) (NNS proteins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))))))))))) (, ,) (CC and) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB regulate) (NP (NN signalling)) (PP (IN by) (NP (JJ many) (NN cell) (NN surface) (NNS receptors)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT_) (NN proto-oncogene)))) (VP (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (JJ several) (NNS proteins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (, ,) (CC and) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB regulate) (NP (NN signalling)) (PP (IN by) (NP (JJ many) (NN cell) (NN surface) (NNS receptors)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT_) (NN proto-oncogene)))) (VP (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NP (JJ several) (NNS proteins)) (, ,) (PP (VBG including) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (, ,) (CC and) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB regulate) (NP (NN signalling)) (PP (IN by) (NP (JJ many) (NN cell) (NN surface) (NNS receptors)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ precise) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT these) (NNS pathways)))) (VP (VBZ is) (RB not) (ADJP (JJ clear)) (, ,) (SBAR (IN although) (S (NP (NP (DT a) (JJ genetic) (NN analysis)) (PP (IN in) (NP (NN Caenorhabditis) (NNS elegans)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ precise) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT these) (NNS pathways)))) (VP (VBZ is) (RB not) (ADJP (JJ clear)) (, ,) (SBAR (IN although) (S (NP (NP (DT a) (JJ genetic) (NN analysis)) (PP (IN in) (NP (NN Caenorhabditis) (NNS elegans)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ precise) (NN function)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (DT these) (NNS pathways)))) (VP (VBZ is) (RB not) (ADJP (JJ clear)) (, ,) (SBAR (IN although) (S (NP (NP (DT a) (JJ genetic) (NN analysis)) (PP (IN in) (NP (NN Caenorhabditis) (NNS elegans)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ precise) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT these) (NNS pathways)))) (VP (VBZ is) (RB not) (ADJP (JJ clear)) (, ,) (SBAR (IN although) (S (NP (NP (DT a) (JJ genetic) (NN analysis)) (PP (IN in) (NP (NN Caenorhabditis) (NNS elegans)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ precise) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT these) (NNS pathways)))) (VP (VBZ is) (RB not) (ADJP (JJ clear)) (, ,) (SBAR (IN although) (S (NP (NP (DT a) (JJ genetic) (NN analysis)) (PP (IN in) (NP (NN Caenorhabditis) (NNS elegans)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ precise) (NN function)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (DT these) (NNS pathways)))) (VP (VBZ is) (RB not) (ADJP (JJ clear)) (, ,) (SBAR (IN although) (S (NP (NP (DT a) (JJ genetic) (NN analysis)) (PP (IN in) (NP (NN Caenorhabditis) (NNS elegans)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN of) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN screen)) (VP (VBD identified) (NP (NP (NNS interactions)) (VP (VBG involving) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (CD two) (NN 14-3-3) (NNS isoforms)) (, ,) (NP (NP (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NP (JJ human) (JJ unconventional) (NN myosin)) (NN IC)) (, ,) (CC and) (NP (NP (DT a) (ADJP (RB recently) (VBN identified)) (NN SH3) (NN domain) (NN containing) (NN protein)) (, ,) (NP (NN _PROT_) (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN screen)) (VP (VBD identified) (NP (NP (NNS interactions)) (VP (VBG involving) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (CD two) (NN 14-3-3) (NNS isoforms)) (, ,) (NP (NP (NN _PROT_) (CD _PROT_)) (, ,) (NP (NP (JJ human) (JJ unconventional) (NN myosin)) (NN IC)) (, ,) (CC and) (NP (NP (DT a) (ADJP (RB recently) (VBN identified)) (NN SH3) (NN domain) (NN containing) (NN protein)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN screen)) (VP (VBD identified) (NP (NP (NNS interactions)) (VP (VBG involving) (NP (NP (NN _PROT_)) (CC and) (NP (NP (CD two) (NN 14-3-3) (NNS isoforms)) (, ,) (NP (NP (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NP (JJ human) (JJ unconventional) (NN myosin)) (NN IC)) (, ,) (CC and) (NP (NP (DT a) (ADJP (RB recently) (VBN identified)) (NN SH3) (NN domain) (NN containing) (NN protein)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NP (JJ mesenchymal) (NNS cells)) (PP (IN in) (NP (DT the) (JJ outer) (JJ fibrous) (NN layer)))) (CC and) (NP (NP (NNS chondrocytes)) (PP (IN in) (NP (DT the) (JJ inner) (JJ cartilaginous) (NN matrix)))))) (, ,) (S (ADJP (JJ positive) (PP (IN for) (NP (NP (NNP _PROT2_) (CD _PROT2_)) (CC and) (NP (NNP _PROT_) (CD _PROT_)))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NP (JJ mesenchymal) (NNS cells)) (PP (IN in) (NP (DT the) (JJ outer) (JJ fibrous) (NN layer)))) (CC and) (NP (NP (NNS chondrocytes)) (PP (IN in) (NP (DT the) (JJ inner) (JJ cartilaginous) (NN matrix)))))) (, ,) (S (ADJP (JJ positive) (PP (IN for) (NP (NP (NNP _PROT_) (CD _PROT_)) (CC and) (NP (NNP _PROT2_) (CD _PROT2_)))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NP (JJ mesenchymal) (NNS cells)) (PP (IN in) (NP (DT the) (JJ outer) (JJ fibrous) (NN layer)))) (CC and) (NP (NP (NNS chondrocytes)) (PP (IN in) (NP (DT the) (JJ inner) (JJ cartilaginous) (NN matrix)))))) (, ,) (S (ADJP (JJ positive) (PP (IN for) (NP (NP (NNP _PROT1_) (CD _PROT1_)) (CC and) (NP (NNP _PROT2_) (CD _PROT2_)))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This)) (VP (VP (VBZ is) (NP (NP (DT the) (JJ first) (NN study)) (S (VP (TO to) (VP (VBP provide) (NP (NP (JJ observational) (NN evidence)) (PP (IN of) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NN _PROT1_) (NN signaling))) (PP (IN in) (NP (NP (DT the) (NN pathogenesis)) (PP (IN of) (NP (NP (NN cartilage) (NN cap)) (PP (IN of) (NP (NN osteochondroma.))))))))))))))) (CC and) (VP (VBZ suggests) (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN growth)) (PP (IN of) (NP (NP (JJ cartilage) (NN cap)) (PP (IN in) (NP (NN osteochondroma)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (NN involvement) (PP (IN in) (NP (NP (DT the) (JJ osteogenic) (NNS properties)) (PP (IN of) (NP (DT the) (NN HeLa) (NN cell) (NN line))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP postulate) (SBAR (IN that) (S (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NN bone) (NN induction)))) (VP (VBZ is) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NN bone) (JJ morphogenetic) (NNS proteins) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN by) (NP (DT the) (JJ grafted) (NN HeLa) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)) (CC versus) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)) (CC versus) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)) (CC versus) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (CC versus) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)) (CC versus) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)) (CC versus) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS levels)) (VP (VBD were) (ADJP (RB statistically) (JJR greater)) (PP (IN in) (NP (NNS patients))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS levels)) (VP (VBD were) (ADJP (RB statistically) (JJR greater)) (PP (IN in) (NP (NNS patients))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS levels)) (VP (VBD were) (ADJP (RB statistically) (JJR greater)) (PP (IN in) (NP (NNS patients))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Isolation)) (PP (IN of) (NP (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN binding) (NN specificity)) (PP (IN with) (NP (NN _PROT2_) (CD _PROT2_))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD screened) (NP (NNS proteins)) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)))))) (, ,) (CC and) (VP (VBD cloned) (NP (NP (DT the) (JJ full-length) (NN cDNA)) (PP (IN of) (NP (JJ human) (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD encoded) (NP (NN 1225) (NN amino) (NNS acids))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Yeast) (JJ two-hybrid) (NN assay)) (, ,) (NP (NN GST) (NN binding) (NN assay)) (CC and) (NP (NN immunoprecipitation))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (DT a) (JJ hydrophilic) (NN loop) (NN region)) (PP (IN in) (NP (NP (DT the) (JJ endoproteolytic) (JJ C-terminal) (NN fragment)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Yeast) (JJ two-hybrid) (NN assay)) (, ,) (NP (NN GST) (NN binding) (NN assay)) (CC and) (NP (NN immunoprecipitation))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (DT a) (JJ hydrophilic) (NN loop) (NN region)) (PP (IN in) (NP (NP (DT the) (JJ endoproteolytic) (JJ C-terminal) (NN fragment)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Yeast) (JJ two-hybrid) (NN assay)) (, ,) (NP (NN GST) (NN binding) (NN assay)) (CC and) (NP (NN immunoprecipitation))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (DT a) (JJ hydrophilic) (NN loop) (NN region)) (PP (IN in) (NP (NP (DT the) (JJ endoproteolytic) (JJ C-terminal) (NN fragment)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (RB partly)) (VP (VBP differ) (PP (IN in) (NP (NN function)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD found) (S (NP (NP (DT another) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD found) (S (NP (NP (DT another) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD found) (S (NP (NP (DT another) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Ligation)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN cell) (NN surface) (NN receptor) (JJ _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ elicits) (NP (NP (DT a) (JJ characteristic) (VBN programmed) (NN death) (NN response)) (PP (IN in) (NP (JJ susceptible) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Ligation)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN cell) (NN surface) (NN receptor) (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ elicits) (NP (NP (DT a) (JJ characteristic) (VBN programmed) (NN death) (NN response)) (PP (IN in) (NP (JJ susceptible) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Ligation)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN cell) (NN surface) (NN receptor) (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ elicits) (NP (NP (DT a) (JJ characteristic) (VBN programmed) (NN death) (NN response)) (PP (IN in) (NP (JJ susceptible) (NNS cells)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (: :) (NP (NP (NN _PROT2_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT_)) (, ,) (PP (IN for) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (: :) (NP (NP (NN _PROT_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT2_)) (, ,) (PP (IN for) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (: :) (NP (NP (NN _PROT_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT_)) (, ,) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (: :) (NP (NP (NN _PROT1_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT2_)) (, ,) (PP (IN for) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (: :) (NP (NP (NN _PROT1_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT_)) (, ,) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (: :) (NP (NP (NN _PROT_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT1_)) (, ,) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT2_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (NP (DT an) (JJ N-terminal) (NN region)) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NN protein) (NNS kinases)))))) (CC and) (NP (NP (DT a) (JJ C-terminal) (NN region)) (VP (VBG containing) (NP (NP (NP (DT a) (JJ cytoplasmic) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN death) (NN domain)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (JJ intracellular) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (NP (DT an) (JJ N-terminal) (NN region)) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NN protein) (NNS kinases)))))) (CC and) (NP (NP (DT a) (JJ C-terminal) (NN region)) (VP (VBG containing) (NP (NP (NP (DT a) (JJ cytoplasmic) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN death) (NN domain)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (JJ intracellular) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ contains) (NP (NP (NP (DT an) (JJ N-terminal) (NN region)) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NN protein) (NNS kinases)))))) (CC and) (NP (NP (DT a) (JJ C-terminal) (NN region)) (VP (VBG containing) (NP (NP (NP (DT a) (JJ cytoplasmic) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN death) (NN domain)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (JJ intracellular) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Molecular) (NN cloning)) (CC and) (NP (NN expression))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (NN _PROT1_)))))) (VP (VBZ reveals) (NP (NP (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (JJ transcriptional) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Molecular) (NN cloning)) (CC and) (NP (NN expression))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (NN _PROT1_)))))) (VP (VBZ reveals) (NP (NP (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (JJ transcriptional) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Molecular) (NN cloning)) (CC and) (NP (NN expression))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (NN _PROT_)))))) (VP (VBZ reveals) (NP (NP (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (JJ transcriptional) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT2_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT2_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT2_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NP (NP (NN cloning)) (, ,) (NP (NN expression)) (, ,) (CC and) (NP (JJ biochemical) (NN characterization)))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-)) (NN _PROT1_))) (, ,) (VP (VBN termed) (S (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (JJ human) (NN homologue)) (PP (IN of) (NP (NN Drosophila) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT a) (JJ partial) (JJ recombinant) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NN _PROT2_)))) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG mediating) (NP (NP (ADJP (FW in) (FW vitro)) (JJ transcriptional) (NN activation)) (PP (IN by) (NP (DT the) (NN _PROT_) (NN activation) (NN domain)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT a) (JJ partial) (JJ recombinant) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NN _PROT_)))) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG mediating) (NP (NP (ADJP (FW in) (FW vitro)) (JJ transcriptional) (NN activation)) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN activation) (NN domain)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT a) (JJ partial) (JJ recombinant) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NN _PROT1_)))) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG mediating) (NP (NP (ADJP (FW in) (FW vitro)) (JJ transcriptional) (NN activation)) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN activation) (NN domain)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Biochemical) (NNS studies)) (VP (VBD established) (SBAR (IN that) (S (NP (DT some) (NNS coactivators)) (VP (VBP are) (VP (VBN associated) (PP (IN with) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT_) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Biochemical) (NNS studies)) (VP (VBD established) (SBAR (IN that) (S (NP (DT some) (NNS coactivators)) (VP (VBP are) (VP (VBN associated) (PP (IN with) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Biochemical) (NNS studies)) (VP (VBD established) (SBAR (IN that) (S (NP (DT some) (NNS coactivators)) (VP (VBP are) (VP (VBN associated) (PP (IN with) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (CD _PROT1_) (NN gene)) (VP (VBZ is) (ADJP (JJ identical) (PP (TO to) (NP (NP (NP (NP (DT a) (NN gene)) (, ,) (NP (NN _PROT2_)) (, ,)) (PRN (-LRB- -LRB-) (NP (JJ ref) (NN 7,8)) (-RRB- -RRB-))) (, ,) (VP (VBN implicated) (PP (IN in) (NP (JJ cell-cycle) (NN progression))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Recombinant) (CD _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (NP (NN _PROT2_)) (UCP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (PP (IN in) (NP (NN yeast))) (, ,))))) (CC and) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Recombinant) (CD _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (NP (NN _PROT_)) (UCP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (PP (IN in) (NP (NN yeast))) (, ,))))) (CC and) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Recombinant) (CD _PROT_)) (VP (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (NP (NN _PROT1_)) (UCP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (PP (IN in) (NP (NN yeast))) (, ,))))) (CC and) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJS largest) (NN TAF)) (VP (MD may) (ADVP (RB therefore)) (VP (VB play) (NP (DT a) (JJ central) (NN role)) (PP (IN in) (NP (NN _PROT1_) (NN assembly))) (PP (IN by) (S (VP (VP (VBG interacting) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (JJ other) (NNS TAFs))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (VP (VBG serving) (S (VP (TO to) (VP (VB link) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NN transcription)))) (PP (TO to) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (JJ functional) (NN analysis))) (PP (IN of) (NP (NN _PROT1_)))) (: :) (NP (NP (DT a) (JJ novel) (NN _PROT2_) (NN _PROT_)) (PP (IN with) (NP (JJ anti-cell) (NN death) (NN activity)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (JJ functional) (NN analysis))) (PP (IN of) (NP (NN _PROT1_)))) (: :) (NP (NP (DT a) (JJ novel) (NN _PROT2_) (NN _PROT2_)) (PP (IN with) (NP (JJ anti-cell) (NN death) (NN activity)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (JJ functional) (NN analysis))) (PP (IN of) (NP (NN _PROT_)))) (: :) (NP (NP (DT a) (JJ novel) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PP (IN with) (NP (JJ anti-cell) (NN death) (NN activity)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN protein) (NN interaction) (NN cloning) (NN technique)))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS cDNAs)) (SBAR (WHNP (WDT that)) (S (VP (VBP encode) (NP (NP (DT a) (JJ novel) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (, ,) (VP (VBN termed) (S (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN protein) (NN interaction) (NN cloning) (NN technique)))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS cDNAs)) (SBAR (WHNP (WDT that)) (S (VP (VBP encode) (NP (NP (DT a) (JJ novel) (JJ _PROT1_) (NN _PROT_)) (, ,) (VP (VBN termed) (S (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN protein) (NN interaction) (NN cloning) (NN technique)))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS cDNAs)) (SBAR (WHNP (WDT that)) (S (VP (VBP encode) (NP (NP (DT a) (JJ novel) (JJ _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN termed) (S (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN protein)) (VP (VBZ shares) (NP (NP (DT no) (JJ significant) (NN homology)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (JJ other) (NN _PROT_) (NN family) (NNS proteins)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB form) (NP (NP (ADJP (JJ homo-))) (CC and) (NP (NNS heterodimers)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN protein)) (VP (VBZ shares) (NP (NP (DT no) (JJ significant) (NN homology)) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (JJ other) (NN _PROT2_) (NN family) (NNS proteins)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB form) (NP (NP (ADJP (JJ homo-))) (CC and) (NP (NNS heterodimers)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN protein)) (VP (VBZ shares) (NP (NP (DT no) (JJ significant) (NN homology)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (JJ other) (NN _PROT2_) (NN family) (NNS proteins)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB form) (NP (NP (ADJP (JJ homo-))) (CC and) (NP (NNS heterodimers)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NP (NN _PROT_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT2_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NP (NN _PROT_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT2_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (NN _PROT2_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP indicate) (SBAR (IN that) (S (NP (NN bag-1)) (VP (VBZ represents) (NP (NP (DT a) (JJ new) (NN type)) (PP (IN of) (NP (JJ anti-cell) (NN death) (NN gene)))))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT some) (NNS routes)) (PP (IN of) (NP (NP (NN apoptosis) (NN induction)) (VP (ADVP (RB previously)) (VBN ascribed) (PP (TO to) (NP (JJ _PROT1_) (NNS pathways))))))) (VP (MD may) (ADVP (RB instead)) (VP (VB reflect) (NP (NP (DT a) (NN need)) (PP (IN for) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP indicate) (SBAR (IN that) (S (NP (NN bag-1)) (VP (VBZ represents) (NP (NP (DT a) (JJ new) (NN type)) (PP (IN of) (NP (JJ anti-cell) (NN death) (NN gene)))))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT some) (NNS routes)) (PP (IN of) (NP (NP (NN apoptosis) (NN induction)) (VP (ADVP (RB previously)) (VBN ascribed) (PP (TO to) (NP (JJ _PROT1_) (NNS pathways))))))) (VP (MD may) (ADVP (RB instead)) (VP (VB reflect) (NP (NP (DT a) (NN need)) (PP (IN for) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP indicate) (SBAR (IN that) (S (NP (NN bag-1)) (VP (VBZ represents) (NP (NP (DT a) (JJ new) (NN type)) (PP (IN of) (NP (JJ anti-cell) (NN death) (NN gene)))))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT some) (NNS routes)) (PP (IN of) (NP (NP (NN apoptosis) (NN induction)) (VP (ADVP (RB previously)) (VBN ascribed) (PP (TO to) (NP (JJ _PROT_) (NNS pathways))))))) (VP (MD may) (ADVP (RB instead)) (VP (VB reflect) (NP (NP (DT a) (NN need)) (PP (IN for) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN with) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (PP (IN by) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN with) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN with) (NP (NP (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ few) (JJ general) (NN transcription) (NNS factors)) (, ,) (PP (IN in) (NP (NP (JJ particular) (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP have) (VP (VBN been) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (NP (JJ transcriptional) (NNS activators))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT1_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT1_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT1_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT2_) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Further)) (, ,) (NP (NP (NN _PROT1_) (POS 's)) (JJ central) (JJ charged) (NN cluster) (NN domain)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NP (NN _PROT2_) (POS 's)) (NN activation) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion)) (PP (IN of) (NP (DT this) (NN domain)))) (VP (VP (VBZ impairs) (NP (NN _PROT1_) (POS 's) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT2_) (NN transcription)) (ADVP (FW in) (FW vitro))))))) (CC but) (VP (VBZ has) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN protein) (POS 's) (JJ basal) (NN transcription) (NN activity)) (CC or) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion)) (PP (IN of) (NP (DT this) (NN domain)))) (VP (VP (VBZ impairs) (NP (NN _PROT1_) (POS 's) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT_) (NN transcription)) (ADVP (FW in) (FW vitro))))))) (CC but) (VP (VBZ has) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN protein) (POS 's) (JJ basal) (NN transcription) (NN activity)) (CC or) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion)) (PP (IN of) (NP (DT this) (NN domain)))) (VP (VP (VBZ impairs) (NP (NN _PROT_) (POS 's) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT1_) (NN transcription)) (ADVP (FW in) (FW vitro))))))) (CC but) (VP (VBZ has) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN protein) (POS 's) (JJ basal) (NN transcription) (NN activity)) (CC or) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT2_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT2_) (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT2_) (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT_) (NN signaling)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT2_) (NN signaling)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT2_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT2_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))) (, ,) (NP (NP (DT the) (NN nature)) (PP (IN of) (NP (DT the) (NN interaction)))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN defined))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))) (, ,) (NP (NP (DT the) (NN nature)) (PP (IN of) (NP (DT the) (NN interaction)))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN defined))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))))) (, ,) (NP (NP (DT the) (NN nature)) (PP (IN of) (NP (DT the) (NN interaction)))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN defined))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (DT the) (JJ two-hybrid) (NN assay)) (PP (IN of) (NP (JJ protein-protein) (NN interaction))) (PP (IN in) (NP (DT the) (NN yeast) (NN Saccharomyces) (NN cerevisiae)))) (S (VP (TO to) (VP (VB study) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (DT the) (JJ two-hybrid) (NN assay)) (PP (IN of) (NP (JJ protein-protein) (NN interaction))) (PP (IN in) (NP (DT the) (NN yeast) (NN Saccharomyces) (NN cerevisiae)))) (S (VP (TO to) (VP (VB study) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (DT the) (JJ two-hybrid) (NN assay)) (PP (IN of) (NP (JJ protein-protein) (NN interaction))) (PP (IN in) (NP (DT the) (NN yeast) (NN Saccharomyces) (NN cerevisiae)))) (S (VP (TO to) (VP (VB study) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ forms) (NP (NP (DT a) (JJ specific) (NN complex)) (PP (IN with) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT both)) (VP (VBP are) (VP (VBN expressed) (PP (IN as) (NP (NP (NN hybrid) (NNS proteins)) (PP (IN in) (NP (NN yeast) (NNS cells)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Lastly)) (, ,) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (PRP$ our) (NNS findings)) (PP (IN for) (NP (NN yeast) (NNS cells))))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ unable) (S (VP (TO to) (VP (VB phosphorylate) (NP (NP (DT an) (NN _PROT2_) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN deletion)) (PP (IN of) (NP (NN amino) (NNS acids) (NP (CD 45) (TO to) (CD 516))))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (JJ mammalian) (NN splicing) (NN factor) (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_)))) (CC and) (NP (NP (NN relation)) (PP (IN of) (NP (PRP$ its) (JJ 60-kD) (NN subunit))) (PP (TO to) (NP (NN yeast) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (JJ mammalian) (NN splicing) (NN factor) (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (NP (NP (NN relation)) (PP (IN of) (NP (PRP$ its) (JJ 60-kD) (NN subunit))) (PP (TO to) (NP (NN yeast) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (JJ mammalian) (NN splicing) (NN factor) (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (NP (NP (NN relation)) (PP (IN of) (NP (PRP$ its) (JJ 60-kD) (NN subunit))) (PP (TO to) (NP (NN yeast) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (DT a) (NN prespliceosome))))) (, ,) (NP (NP (NN _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN snRNP)) (-RRB- -RRB-))) (VP (VBZ functions) (PP (IN in) (NP (NP (NN pre-messenger) (NN RNA) (-LRB- -LRB-) (NN mRNA) (-RRB- -RRB-) (NN splicing)) (PP (ADVP (RB together)) (IN with) (NP (NP (NP (NN splicing) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS SFs)) (-RRB- -RRB-))) (NP (NN 3a)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ several) (JJ other) (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP it)) (VP (VBZ is) (VP (VBN shown) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NNS subunits)) (VP (VBP correspond) (PP (TO to) (NP (NP (CD three)) (PP (IN of) (NP (DT the) (NN 17S) (NN _PROT2_) (JJ _PROT2_) (NNS polypeptides))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT2_) (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT2_) (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT2_) (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT1_) (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT1_) (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT1_) (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT the) (NN 60-kilodalton) (NN subunit)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN yeast) (NN splicing) (NN protein) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN Cdk-interacting) (NN protein) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ potent) (NN inhibitor)) (PP (IN of) (NP (NN G1) (JJ cyclin-dependent) (NNS kinases)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ cyclin-dependent) (NN kinase)) (NP (NN _PROT1_))) (VP (VP (VBZ associates) (PP (IN with) (NP (NNS _PROT2_) (NP (NP (NN _PROT2_)) (, ,) (NP (NN D)) (, ,) (CC and) (NP (NN E)))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NP (DT the) (NN G1)) (PP (TO to) (NP (NN S) (NN phase) (NN transition))) (PP (IN in) (NP (NNS mammals)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Cotransfection) (NNS experiments)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (VP (VBP function) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ antagonistic)) (NN manner))) (S (VP (TO to) (VP (VB control) (NP (NN cell) (NN cycle) (NN progression)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VP (VBN cloned)) (CC and) (VP (VBN characterized)) (NP (NP (JJ human) (JJ _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_) (CD _PROT1_)) (-RRB- _PROT1_)) (NN _PROT1_)) (CC and) (NP (NP (DT a) (JJ second) (NN isoform)) (PP (IN of) (NP (JJ human) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (CD _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN deduced) (NN amino) (NN acid) (NNS sequences)) (PP (IN of) (NP (NP (JJ human) (NN alpha) (CD 1-)) (CC and) (NP (NN _PROT1_)) (NP (NN _PROT1_))))) (VP (VBP are) (ADJP (RB nearly) (JJ identical) (PP (TO to) (NP (NP (PRP$ their) (NNS homologues)) (PP (IN in) (NP (NN mouse)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ strong) (JJ functional) (NN conservation)) (PP (IN among) (NP (NP (DT the) (JJ individual) (NNS isoforms)) (, ,) (S (PP (ADVP (RB Much)) (IN like) (NP (NN _PROT2_) (NN _PROT2_))) (, ,) (NP (JJ human) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ has) (NP (JJ multiple) (NN transcript) (NNS classes))) (CC and) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB widely)) (, ,) (PP (IN although) (PP (IN in) (NP (NP (DT a) (JJ distinct) (NN pattern)) (PP (IN of) (NP (JJ relative) (NN abundance))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN deduced) (NN amino) (NN acid) (NNS sequences)) (PP (IN of) (NP (NP (JJ human) (NN alpha) (CD 1-)) (CC and) (NP (NN _PROT1_)) (NP (NN _PROT1_))))) (VP (VBP are) (ADJP (RB nearly) (JJ identical) (PP (TO to) (NP (NP (PRP$ their) (NNS homologues)) (PP (IN in) (NP (NN mouse)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ strong) (JJ functional) (NN conservation)) (PP (IN among) (NP (NP (DT the) (JJ individual) (NNS isoforms)) (, ,) (S (PP (ADVP (RB Much)) (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (JJ human) (NN _PROT2_) (NN _PROT2_)) (VP (VP (VBZ has) (NP (JJ multiple) (NN transcript) (NNS classes))) (CC and) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB widely)) (, ,) (PP (IN although) (PP (IN in) (NP (NP (DT a) (JJ distinct) (NN pattern)) (PP (IN of) (NP (JJ relative) (NN abundance))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN deduced) (NN amino) (NN acid) (NNS sequences)) (PP (IN of) (NP (NP (JJ human) (NN alpha) (CD 1-)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (RB nearly) (JJ identical) (PP (TO to) (NP (NP (PRP$ their) (NNS homologues)) (PP (IN in) (NP (NN mouse)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ strong) (JJ functional) (NN conservation)) (PP (IN among) (NP (NP (DT the) (JJ individual) (NNS isoforms)) (, ,) (S (PP (ADVP (RB Much)) (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (JJ human) (NN _PROT2_) (NN _PROT2_)) (VP (VP (VBZ has) (NP (JJ multiple) (NN transcript) (NNS classes))) (CC and) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB widely)) (, ,) (PP (IN although) (PP (IN in) (NP (NP (DT a) (JJ distinct) (NN pattern)) (PP (IN of) (NP (JJ relative) (NN abundance))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Somatic) (NN cell) (NNS hybrids)) (CC and) (NP (JJ fluorescent) (ADJP (FW in) (FW situ)) (NN hybridization))) (VP (VBD were) (ADVP (DT both)) (VP (VBN used) (S (VP (TO to) (VP (VB determine) (NP (NP (PRP$ their) (JJ chromosomal) (NNS locations)) (: :) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PP (TO to) (NP (NN chromosome) (CD 16q22-23)))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (TO to) (NP (NN chromosome) (CD 20q11.2)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ carboxy-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ has) (ADVP (RB previously)) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ cytoplasmic) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))) (, ,))) (PP (IN by) (NP (NP (ADJP (FW in) (FW vitro)) (JJ biochemical) (NNS studies)) (PP (JJ such) (IN as) (NP (NP (NN overlay) (NN assay)) (CC or) (NP (NN immunoprecipitation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ carboxy-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ has) (ADVP (RB previously)) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ cytoplasmic) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))) (, ,))) (PP (IN by) (NP (NP (ADJP (FW in) (FW vitro)) (JJ biochemical) (NNS studies)) (PP (JJ such) (IN as) (NP (NP (NN overlay) (NN assay)) (CC or) (NP (NN immunoprecipitation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ carboxy-terminal) (NN region)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ has) (ADVP (RB previously)) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ cytoplasmic) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))) (, ,))) (PP (IN by) (NP (NP (ADJP (FW in) (FW vitro)) (JJ biochemical) (NNS studies)) (PP (JJ such) (IN as) (NP (NP (NN overlay) (NN assay)) (CC or) (NP (NN immunoprecipitation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (DT a) (JJ critical) (NN ligand) (NN binding) (NN determinant)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN Evidence)) (PP (IN for) (NP (NP (JJ common) (NN ligand) (NN binding) (NNS motifs)) (PP (IN in) (NP (DT the) (NN cytokine) (NN receptor) (NN family))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NN cytokine)) (CC and) (NP (NN growth)) (NP (NN factor) (NNS receptors)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP share) (NP (NP (JJ conserved) (NNS features)) (PP (IN in) (NP (PRP$ their) (ADJP (ADJP (JJ extracellular)) (CC and) (ADJP (JJ cytoplasmic))) (NNS domains)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NN cytokine)) (CC and) (NP (NN growth)) (NP (NN factor) (NNS receptors)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP share) (NP (NP (JJ conserved) (NNS features)) (PP (IN in) (NP (PRP$ their) (ADJP (ADJP (JJ extracellular)) (CC and) (ADJP (JJ cytoplasmic))) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NN cytokine)) (CC and) (NP (NN growth)) (NP (NN factor) (NNS receptors)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP share) (NP (NP (JJ conserved) (NNS features)) (PP (IN in) (NP (PRP$ their) (ADJP (ADJP (JJ extracellular)) (CC and) (ADJP (JJ cytoplasmic))) (NNS domains)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NP (JJ site-specific) (NN mutagenesis)) (PP (IN within) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_)))))) (S (VP (TO to) (VP (VB search) (PP (IN for) (NP (NP (NN amino) (NN acid) (NNS residues)) (VP (VBN involved) (PP (IN in) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NP (JJ site-specific) (NN mutagenesis)) (PP (IN within) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_)))))) (S (VP (TO to) (VP (VB search) (PP (IN for) (NP (NP (NN amino) (NN acid) (NNS residues)) (VP (VBN involved) (PP (IN in) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NP (JJ site-specific) (NN mutagenesis)) (PP (IN within) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT_)))))) (S (VP (TO to) (VP (VB search) (PP (IN for) (NP (NP (NN amino) (NN acid) (NNS residues)) (VP (VBN involved) (PP (IN in) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (NNS bacteria))) (PP (IN as) (NP (NP (JJ soluble) (NN _PROT1_) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (CC and) (VP (VBN characterized) (PP (IN for) (NP (NN _PROT_) (NN binding) (NN activity))) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ different) (NNS assays))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (NNS bacteria))) (PP (IN as) (NP (NP (JJ soluble) (NN _PROT1_) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (CC and) (VP (VBN characterized) (PP (IN for) (NP (NN _PROT2_) (NN binding) (NN activity))) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ different) (NNS assays))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (NNS bacteria))) (PP (IN as) (NP (NP (JJ soluble) (NN _PROT_) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (CC and) (VP (VBN characterized) (PP (IN for) (NP (NN _PROT2_) (NN binding) (NN activity))) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ different) (NNS assays))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Substitution)) (PP (IN of) (NP (NN phenylalanine))) (PP (IN at) (NP (NP (NN position) (CD 93)) (PRN (-LRB- -LRB-) (NP (NN Phe93)) (-RRB- -RRB-)))) (PP (IN with) (NP (NP (NN alanine)) (PRN (-LRB- -LRB-) (NP (NN F93A) (NN mutation)) (-RRB- -RRB-))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ drastic) (NN reduction)) (PP (IN in) (NP (NN _PROT1_) (NN binding))) (PP (IN in) (NP (DT the) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT the) (NN F93A) (NN mutation)) (PP (IN in) (NP (NP (JJ full-length) (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells))))))) (VP (VBD abolished) (NP (JJ detectable) (NN _PROT2_) (NN binding)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN _PROT1_) (NN binding) (NN determinant)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ cytokine-activated) (NN tyrosine) (NN kinase) (NN _PROT1_)) (VP (VBZ activates) (NP (NN _PROT2_)) (PP (IN in) (NP (DT a) (JJ _PROT_) (NN manner))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ cytokine-activated) (NN tyrosine) (NN kinase) (NN _PROT1_)) (VP (VBZ activates) (NP (NN _PROT_)) (PP (IN in) (NP (DT a) (JJ _PROT2_) (NN manner))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ cytokine-activated) (NN tyrosine) (NN kinase) (NN _PROT_)) (VP (VBZ activates) (NP (NN _PROT1_)) (PP (IN in) (NP (DT a) (JJ _PROT2_) (NN manner))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT_) (NN _PROT_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT_) (NN _PROT_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT1_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ baculovirus) (NN coexpression) (NN system))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ baculovirus) (NN coexpression) (NN system))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ baculovirus) (NN coexpression) (NN system))) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN activated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Under) (NP (DT these) (NNS conditions))) (, ,) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Under) (NP (DT these) (NNS conditions))) (, ,) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Under) (NP (DT these) (NNS conditions))) (, ,) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN kinase) (NN activity))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBD phosphorylated) (NP (NN _PROT2_)) (PP (IN at) (NP (NP (NNS sites)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBD phosphorylated) (NP (NN _PROT_)) (PP (IN at) (NP (NP (NNS sites)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT_)) (VP (VBD phosphorylated) (NP (NN _PROT1_)) (PP (IN at) (NP (NP (NNS sites)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ mammalian) (NNS cells)) (VP (VBN treated) (PP (IN with) (NP (CC either) (NP (NN erythropoietin)) (CC or) (NP (NN interferon-gamma))))))) (, ,) (NP (NP (DT a) (JJ small) (NN fraction)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD coimmunoprecipitated) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NNS lysates)) (PP (IN of) (NP (NP (NNS cells)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN activated) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (PRP$ its) (NN state)) (PP (IN of) (NP (NN tyrosine) (NN phosphorylation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ mammalian) (NNS cells)) (VP (VBN treated) (PP (IN with) (NP (CC either) (NP (NN erythropoietin)) (CC or) (NP (NN interferon-gamma))))))) (, ,) (NP (NP (DT a) (JJ small) (NN fraction)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD coimmunoprecipitated) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NNS lysates)) (PP (IN of) (NP (NP (NNS cells)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN activated) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (PRP$ its) (NN state)) (PP (IN of) (NP (NN tyrosine) (NN phosphorylation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ mammalian) (NNS cells)) (VP (VBN treated) (PP (IN with) (NP (CC either) (NP (NN erythropoietin)) (CC or) (NP (NN interferon-gamma))))))) (, ,) (NP (NP (DT a) (JJ small) (NN fraction)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD coimmunoprecipitated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NNS lysates)) (PP (IN of) (NP (NP (NNS cells)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN activated) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (PRP$ its) (NN state)) (PP (IN of) (NP (NN tyrosine) (NN phosphorylation)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP cooperate) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP cooperate) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP cooperate) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN protein) (NNS phosphatases) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (CC and) (VP (VBZ disrupts) (NP (DT a) (NN G2/M) (JJ cell-cycle) (NN checkpoint))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN protein) (NNS phosphatases) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ disrupts) (NP (DT a) (NN G2/M) (JJ cell-cycle) (NN checkpoint))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN protein) (NNS phosphatases) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ disrupts) (NP (DT a) (NN G2/M) (JJ cell-cycle) (NN checkpoint))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN oncogene)) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (NP (NP (NNS targets)) (PP (IN for) (NP (NP (JJ oncogenic) (NNS viruses)) (CC and) (NP (JJ chemical) (NN tumour) (NNS promoters))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN oncogene)) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (NP (NP (NNS targets)) (PP (IN for) (NP (NP (JJ oncogenic) (NNS viruses)) (CC and) (NP (JJ chemical) (NN tumour) (NNS promoters))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN oncogene)) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (NP (NP (NNS targets)) (PP (IN for) (NP (NP (JJ oncogenic) (NNS viruses)) (CC and) (NP (JJ chemical) (NN tumour) (NNS promoters))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Analysis)) (PP (IN of) (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT2_) (NN _PROT_) (NN binding) (NN interface))) (PP (IN at) (NP (DT the) (NN amino) (NN acid) (NN level)))) (: :) (NP (NP (JJ proposed) (NN mechanism)) (PP (IN of) (NP (NN interaction)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Analysis)) (PP (IN of) (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT2_) (NN _PROT2_) (NN binding) (NN interface))) (PP (IN at) (NP (DT the) (NN amino) (NN acid) (NN level)))) (: :) (NP (NP (JJ proposed) (NN mechanism)) (PP (IN of) (NP (NN interaction)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Analysis)) (PP (IN of) (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN binding) (NN interface))) (PP (IN at) (NP (DT the) (NN amino) (NN acid) (NN level)))) (: :) (NP (NP (JJ proposed) (NN mechanism)) (PP (IN of) (NP (NN interaction)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (DT the) (JJ human) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN _PROT_) (NN binding) (NN interface)) (PP (IN by) (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (JJ molecular) (NN modelling)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (DT the) (JJ human) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN _PROT2_) (NN binding) (NN interface)) (PP (IN by) (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (JJ molecular) (NN modelling)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (DT the) (JJ human) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN _PROT2_) (NN binding) (NN interface)) (PP (IN by) (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (JJ molecular) (NN modelling)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (VBG Following) (NP (DT this) (NN hypothesis))) (, ,) (NP (PRP we)) (VP (VBN altered) (PP (IN in) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS residues)) (VP (VBN predicted) (S (VP (VP (TO to) (VP (VB reside) (PP (IN in) (NP (DT the) (NN contact) (NN region))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT each) (JJ other))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (NP (DT the) (NN capacity)) (PP (IN of) (NP (DT these) (NNS mutants))) (S (VP (TO to) (VP (VB form) (NP (NP (DT an) (NN _PROT1_AND_PROT2_) (NN complex)) (CC and) (NP (PRP$ their) (NN ability) (S (VP (TO to) (VP (VB transduce) (NP (DT the) (NN signal))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis) (NNS studies)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN Establishment)) (PP (IN of) (NP (JJ structure-function) (NNS relationships))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Site-specific) (NNS mutants)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (FW Escherichia) (FW coli))) (PP (IN as) (NP (JJ soluble) (NN _PROT1_)))) (CC and) (VP (VBN analyzed) (PP (IN for) (NP (NN _PROT2_) (NN binding))) (PP (IN in) (NP (JJ several) (JJ different) (NN assay) (NNS formats))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (VBN selected) (JJ mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN as) (NP (JJ full-length) (NN _PROT1_))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN COS) (NNS cells)))))) (CC and) (VP (VBN analyzed) (PP (IN for) (NP (NN _PROT2_) (NN binding))) (PP (IN in) (NP (NN receptor) (NN binding) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT these) (NNS methods)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NNS residues)) (SBAR (WHNP (WDT that)) (S (VP (VBP appear) (S (VP (TO to) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (NN _PROT1_) (NN binding)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ other) (NNS residues)) (, ,) (SBAR (WHNP (NP (JJS most)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN conserved) (PP (IN in) (NP (NP (NNS receptors)) (PP (IN of) (NP (NP (DT the) (NN cytokine) (NN receptor) (NN family)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBP appear) (S (VP (TO to) (VP (VB be) (ADJP (JJ necessary) (PP (IN for) (NP (NP (NP (DT the) (JJ proper) (NN folding)) (CC and/or) (NP (NN stability))) (PP (IN of) (NP (DT the) (NN _PROT2_)))))))))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT1_) (NN _PROT_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (JJ important) (NN mediator)) (PP (IN of) (NP (JJ inflammatory) (NN disease)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Each)) (PP (IN of) (NP (DT these) (NNS molecules)))) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Each)) (PP (IN of) (NP (DT these) (NNS molecules)))) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Each)) (PP (IN of) (NP (DT these) (NNS molecules)))) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT2_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT2_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT2_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (PP (IN at) (NP (CD 2.5) (NN A) (NN resolution)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (PP (IN at) (NP (CD 2.5) (NN A) (NN resolution)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (PP (IN at) (NP (CD 2.5) (NN A) (NN resolution)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NN _PROT2_))) (PP (IN with) (NP (DT a) (JJ 1:1) (NN stoichiometry))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN crystal) (NN structure)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (CD three) (JJ immunoglobulin-like) (NNS domains)) (SBAR (WHNP (WDT which)) (S (VP (VB wrap) (PP (IN around) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT the) (NNS structures)) (PP (IN of) (NP (ADJP (RB previously) (VBN described)) (JJ cytokine-receptor) (NNS complexes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (JJ previous) (NN work)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD might) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (JJ _PROT_) (NN repression)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (JJ previous) (NN work)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (MD might) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (JJ _PROT2_) (NN repression)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (JJ previous) (NN work)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (MD might) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (JJ _PROT2_) (NN repression)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT2_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT2_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT1_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Repression)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription)))) (VP (MD may) (VP (VB be) (VP (VBN accomplished) (PP (IN through) (NP (NP (JJ direct) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (DT this) (NN activator)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ physical) (NN interaction)) (VP (VBZ is) (RB not) (ADJP (JJ necessary) (PP (IN for) (NP (NN _PROT1_)))) (S (VP (TO to) (VP (VB repress) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (NN transcription)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ physical) (NN interaction)) (VP (VBZ is) (RB not) (ADJP (JJ necessary) (PP (IN for) (NP (NN _PROT1_)))) (S (VP (TO to) (VP (VB repress) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (NN transcription)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ physical) (NN interaction)) (VP (VBZ is) (RB not) (ADJP (JJ necessary) (PP (IN for) (NP (NN _PROT_)))) (S (VP (TO to) (VP (VB repress) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NN transcription)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NN cell) (NN migration))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN cleavage)) (PP (IN of) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN Cleavage)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT2_)))) (CC and) (NP (NP (DT the) (VBG resulting) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ cryptic) (NN site))))) (VP (MD may) (VP (VB provide) (NP (NP (JJ new) (NNS targets)) (PP (IN for) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NN tumor) (NN cell) (NN invasion)) (CC and) (NP (NN tissue) (NN remodeling)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Cleavage)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (VBG resulting) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (JJ cryptic) (NN site))))) (VP (MD may) (VP (VB provide) (NP (NP (JJ new) (NNS targets)) (PP (IN for) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NN tumor) (NN cell) (NN invasion)) (CC and) (NP (NN tissue) (NN remodeling)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Cleavage)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (VBG resulting) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (JJ cryptic) (NN site))))) (VP (MD may) (VP (VB provide) (NP (NP (JJ new) (NNS targets)) (PP (IN for) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NN tumor) (NN cell) (NN invasion)) (CC and) (NP (NN tissue) (NN remodeling)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_AND_PROT2_) (NN complex)) (: :) (NP (NP (NP (JJ structural) (NN basis)) (PP (IN for) (NP (NN GTPase) (NN activation)))) (CC and) (NP (NP (PRP$ its) (NN loss)) (PP (IN in) (NP (JJ oncogenic) (NN _PROT_) (NNS mutants)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (: :) (NP (NP (NP (JJ structural) (NN basis)) (PP (IN for) (NP (NN GTPase) (NN activation)))) (CC and) (NP (NP (PRP$ its) (NN loss)) (PP (IN in) (NP (JJ oncogenic) (NN _PROT2_) (NNS mutants)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (: :) (NP (NP (NP (JJ structural) (NN basis)) (PP (IN for) (NP (NN GTPase) (NN activation)))) (CC and) (NP (NP (PRP$ its) (NN loss)) (PP (IN in) (NP (JJ oncogenic) (NN _PROT2_) (NNS mutants)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT2_) (NN _PROT2_)) (NP (NN _PROT_) (-LRB- -LRB-) (CD _PROT_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT2_) (-LRB- -LRB-) (CD _PROT_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_) (-LRB- -LRB-) (CD _PROT_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT1_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT An) (NN arginine) (JJ side) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN arginine-789)) (-RRB- -RRB-))) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN supplied) (PP (IN into) (NP (NP (DT the) (JJ active) (NN site)) (PP (IN of) (NP (NN _PROT2_))))) (S (VP (TO to) (VP (VBP neutralize) (NP (NP (VBG developing) (NNS charges)) (PP (IN in) (NP (DT the) (NN transition) (NN state)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN switch) (NN II) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN stabilized) (PP (IN by) (NP (NN _PROT2_)))) (, ,) (S (ADVP (RB thus)) (VP (VBG allowing) (NP (NP (NN glutamine-61)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (SBAR (WHNP (NP (NN mutation)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBZ activates) (NP (DT the) (JJ oncogenic) (NN potential))))) (, ,)))) (S (VP (TO to) (VP (VB participate) (PP (IN in) (NP (NN catalysis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN switch) (NN II) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN stabilized) (PP (IN by) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thus)) (VP (VBG allowing) (NP (NP (NN glutamine-61)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (NP (NN mutation)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBZ activates) (NP (DT the) (JJ oncogenic) (NN potential))))) (, ,)))) (S (VP (TO to) (VP (VB participate) (PP (IN in) (NP (NN catalysis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN switch) (NN II) (NN region)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN stabilized) (PP (IN by) (NP (NN _PROT1_)))) (, ,) (S (ADVP (RB thus)) (VP (VBG allowing) (NP (NP (NN glutamine-61)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (NP (NN mutation)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBZ activates) (NP (DT the) (JJ oncogenic) (NN potential))))) (, ,)))) (S (VP (TO to) (VP (VB participate) (PP (IN in) (NP (NN catalysis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Glycine-12)) (PP (IN in) (NP (NP (DT the) (NN transition) (NN state)) (VP (VB mimic))))) (VP (VBZ is) (PP (IN within) (NP (NP (NN van) (NN der) (NN Waals) (NN distance)) (PP (IN of) (NP (CC both) (NP (NP (CD arginine-789)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (CD glutamine-61)) (PP (IN of) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (RB even) (S (NP (NP (PRP$ its) (NN mutation)) (PP (TO to) (NP (NN alanine)))) (VP (MD would) (VP (VBP disturb) (NP (NP (DT the) (NNS arrangements)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (DT the) (NN transition) (NN state))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (ADVP (RB Temporally)) (VBG following) (NP (DT this) (NN growth) (NN arrest)))) (, ,) (S (NP (DT the) (NNS cells)) (VP (VP (VBP develop) (NP (DT a) (NN senescence) (NN morphology))) (CC and) (VP (VBP express) (NP (NP (JJ _PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (ADVP (RB Temporally)) (VBG following) (NP (DT this) (NN growth) (NN arrest)))) (, ,) (S (NP (DT the) (NNS cells)) (VP (VP (VBP develop) (NP (DT a) (NN senescence) (NN morphology))) (CC and) (VP (VBP express) (NP (NP (JJ _PROT_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (ADVP (RB Temporally)) (VBG following) (NP (DT this) (NN growth) (NN arrest)))) (, ,) (S (NP (DT the) (NNS cells)) (VP (VP (VBP develop) (NP (DT a) (NN senescence) (NN morphology))) (CC and) (VP (VBP express) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT2_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT2_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT2_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP rise) (PP (IN in) (NP (NNS HUCs))) (PP (IN during) (NP (JJ progressive) (NNS passages))))) (, ,) (IN whereas) (S (NP (JJ only) (NN _PROT2_)) (VP (VBZ increases) (PP (IN in) (NP (NN HPEC) (NNS cultures)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN induced) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NN _PROT2_)))) (, ,)))) (VP (VBZ produces) (NP (DT a) (JJ senescent-like) (NN phenotype)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP decrease) (PP (IN in) (NP (DT both) (NN cell) (NNS types))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBP are) (ADVP (RB transiently)) (VP (VBN elevated) (PP (IN in) (NP (NP (NNS HPECs)) (CC and) (NP (NNS HUCs)))) (PP (IN at) (NP (NP (DT the) (JJ pre-senescent) (NN growth) (NN arrest)) (, ,) (ADVP (RB then)) (VP (NN return) (PP (TO to) (NP (NP (JJ low) (VBG proliferating) (NNS levels)) (PP (IN at) (NP (JJ terminal) (NN senescence)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ reveals) (NP (NP (JJ altered) (NN expression)) (PP (PP (IN in) (NP (NP (NP (ADJP (ADJP (JJ immortalized)) (, ,) (ADJP (JJ non-tumorigenic))) (NN HPV16) (NN E6)) (CC and) (NP (NN E7))) (NN prostate) (NNS lines))) (CC and) (PP (IN in) (NP (JJ tumorigenic) (NN prostate) (NN cancer) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Positive) (JJ inotropic) (NNS responses)) (VP (VBN mediated) (PP (IN by) (NP (NP (NP (NP (JJ endothelin) (NP (FW _PROT1_))) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (FW _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NP (NNS receptors))) (PP (IN in) (NP (JJ human) (JJ myocardial) (NNS trabeculae))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ present) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB determine) (NP (NP (JJ possible) (JJ inotropic) (NNS effects)) (VP (VBN mediated) (PP (IN by) (NP (NP (NN endothelin) (NP (NP (FW _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))) (CC and) (NP (NP (NP (FW _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NNS receptors)))))) (PP (IN in) (NP (NP (JJ human) (JJ myocardial) (NN trabeculae)) (PP (IN from) (NP (NP (DT the) (JJ right) (NN atrium)) (CC and) (NP (DT the) (JJ left) (NN ventricle))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_))) (VP (VBD had) (NP (DT a) (JJ strong) (JJ positive) (JJ inotropic) (NN effect)) (PP (IN in) (NP (DT all) (NNS trabeculae))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))) (VP (VBD had) (NP (DT a) (JJ strong) (JJ positive) (JJ inotropic) (NN effect)) (PP (IN in) (NP (DT all) (NNS trabeculae))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_))) (VP (VBD had) (NP (DT a) (JJ strong) (JJ positive) (JJ inotropic) (NN effect)) (PP (IN in) (NP (DT all) (NNS trabeculae))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB significantly)) (ADJP (ADJP (RBR more) (JJ potent)) (PP (IN than) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (DT both) (JJ atrial) (PRN (-LRB- -LRB-) (NP (NN P) (JJ <) (CD 0.001)) (-RRB- -RRB-)) (CC and) (NN ventricular) (PRN (-LRB- -LRB-) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)) (NNS trabeculae)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Preincubation)) (PP (IN with) (NP (DT the) (FW _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_) (NN antagonist) (NP (NP (NN FR139317)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-)))))) (VP (VBD decreased) (ADVP (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN P) (JJ <) (CD 0.005)) (-RRB- -RRB-))) (NP (NP (DT the) (NN potency)) (PP (IN of) (NP (JJ _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ atrial)) (CC and) (ADJP (JJ ventricular))) (NNS trabeculae)))) (, ,) (PP (IN without) (NP (NP (DT any) (JJ significant) (NNS changes)) (PP (IN in) (NP (NP (NN Emax)) (-LRB- -LRB-) (NP (NP (JJ maximum) (NN effect)) (VP (VBN obtained) (PP (IN with) (NP (DT an) (NN agonist))))) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (DT The) (FW _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_) (NN agonist) (NN IRL) (NN 1620)) (VP (VBD had) (NP (DT a) (JJ positive) (JJ inotropic) (NN effect)) (PP (ADVP (RB only)) (IN in) (NP (DT some) (NNS trabeculae))))) (, ,) (CC and) (S (NP (NP (DT the) (FW _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (NN antagonist) (NN BQ) (CD 788)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-))) (ADVP (RB almost) (RB completely)) (VP (VBD blocked) (NP (DT this) (NN effect))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT both) (NP (NP (NP (FW _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (FW _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)))) (NNS receptors)) (VP (VBP mediate) (NP (JJ positive) (JJ inotropic) (NNS responses)) (PP (IN at) (NP (NP (CC both) (DT the) (ADJP (ADJP (JJ atrial)) (CC and) (ADJP (JJ ventricular))) (NN level)) (PP (IN in) (NP (DT the) (JJ human) (NN heart)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Apoptotic) (NN proteins.) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (JJ related) (NNS pathways))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (NP (NP (CD two) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (NP (JJ critical) (NNS roles)) (PP (IN in) (NP (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (NN apoptosis)))) (CC and) (NP (DT the) (NN cell) (NN cycle)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ comparative) (NN study)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (NP (ADJP (ADJP (FW de) (FW novo)) (CC and) (ADJP (FW ex))) (NN adenoma) (NN carcinoma)) (PP (IN of) (NP (DT the) (NN colorectum))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN purpose)) (PP (IN of) (NP (DT the) (JJ present) (JJ comparative) (JJ immunohistochemical) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB compare) (NP (NP (NNS rates)) (PP (IN of) (NP (NP (NN cell) (NN adhesion) (NN molecule) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NP (NN protease) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-) (-RRB- -RSB-))) (NP (NN expression))))) (PP (IN in) (NP (NP (NNS groups)) (PP (IN of) (NP (NP (ADJP (FW de) (FW novo)) (PRN (-LRB- -LRB-) (NP (NN n=64)) (-RRB- -RRB-))) (CC and) (NP (FW ex)) (NP (NN adenoma) (-LRB- -LRB-) (NN n=42) (-RRB- -RRB-) (NNS lesions))))))) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB see) (SBAR (IN whether) (S (NP (PRP$ their) (ADJP (RBR more) (JJ aggressive)) (NN behavior)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (NP (VBN decreased) (NN cell) (NN adhesion)) (CC and) (NP (VBN increased) (NN protease) (NN expression)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN purpose)) (PP (IN of) (NP (DT the) (JJ present) (JJ comparative) (JJ immunohistochemical) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB compare) (NP (NP (NNS rates)) (PP (IN of) (NP (NP (NN cell) (NN adhesion) (NN molecule) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NP (NN protease) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-) (-RRB- -RSB-))) (NP (NN expression))))) (PP (IN in) (NP (NP (NNS groups)) (PP (IN of) (NP (NP (ADJP (FW de) (FW novo)) (PRN (-LRB- -LRB-) (NP (NN n=64)) (-RRB- -RRB-))) (CC and) (NP (FW ex)) (NP (NN adenoma) (-LRB- -LRB-) (NN n=42) (-RRB- -RRB-) (NNS lesions))))))) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB see) (SBAR (IN whether) (S (NP (PRP$ their) (ADJP (RBR more) (JJ aggressive)) (NN behavior)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (NP (VBN decreased) (NN cell) (NN adhesion)) (CC and) (NP (VBN increased) (NN protease) (NN expression)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN purpose)) (PP (IN of) (NP (DT the) (JJ present) (JJ comparative) (JJ immunohistochemical) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB compare) (NP (NP (NNS rates)) (PP (IN of) (NP (NP (NN cell) (NN adhesion) (NN molecule) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NP (NN protease) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-) (-RRB- -RSB-))) (NP (NN expression))))) (PP (IN in) (NP (NP (NNS groups)) (PP (IN of) (NP (NP (ADJP (FW de) (FW novo)) (PRN (-LRB- -LRB-) (NP (NN n=64)) (-RRB- -RRB-))) (CC and) (NP (FW ex)) (NP (NN adenoma) (-LRB- -LRB-) (NN n=42) (-RRB- -RRB-) (NNS lesions))))))) (SBAR (IN in) (NN order) (S (VP (TO to) (VP (VB see) (SBAR (IN whether) (S (NP (PRP$ their) (ADJP (RBR more) (JJ aggressive)) (NN behavior)) (VP (VBZ is) (VP (VBN associated) (PP (IN with) (NP (NP (VBN decreased) (NN cell) (NN adhesion)) (CC and) (NP (VBN increased) (NN protease) (NN expression)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS rates)) (PP (IN of) (NP (NP (JJ extensive) (NN _PROT1_) (NN expression)) (CC and) (NP (VBN decreased) (NN _PROT2_) (NN expression))))) (VP (VBD were) (ADJP (RB significantly) (JJR higher)) (PP (IN in) (NP (NP (DT the) (ADJP (FW de) (FW novo)) (NN group)) (PRN (-LRB- -LRB-) (NP (NP (NP (NN P=0.014)) (CC and) (NP (CD 0.005))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD performed) (NP (NP (JJ cell-free) (ADJP (FW in) (FW vitro)) (NN infection)) (PP (IN of) (NP (NP (JJ primary) (NN bone) (NN marrow) (VBN derived) (JJ _PROT1_) (NNS cells)) (VP (VBG using) (NP (NP (JJ semi-purified) (NN HHV8)) (CC and) (NP (NP (DT a) (JJ mature) (ADJP (NN _PROT2_) (JJ dependent)) (NN T) (NN cell) (NN line)) (, ,) (NP (NN KIT) (NN 225)))))))) (, ,) (S (VP (VBG using) (NP (NP (ADJP (RB highly) (VBN concentrated)) (JJ viral) (NNS stocks)) (VP (VBN prepared) (PP (IN from) (NP (NP (DT an) (JJ infectious) (JJ molecular) (NN clone)) (PP (IN of) (NP (NN HTLV-1)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Of) (NP (DT these) (CD 400))) (, ,) (NP (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (JJ TBP-associated) (NN factor)) (, ,) (NP (JJ eukaryotic) (NN elongation) (NN factor)) (CC and) (NP (NN _PROT_) (CD _PROT_))) (VP (VBD were) (VP (VBN up-regulated) (ADVP (RBR more) (IN than) (NP (CD 3.5) (NN fold)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Of) (NP (DT these) (CD 400))) (, ,) (NP (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (JJ TBP-associated) (NN factor)) (, ,) (NP (JJ eukaryotic) (NN elongation) (NN factor)) (CC and) (NP (NN _PROT_) (CD _PROT_))) (VP (VBD were) (VP (VBN up-regulated) (ADVP (RBR more) (IN than) (NP (CD 3.5) (NN fold)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Of) (NP (DT these) (CD 400))) (, ,) (NP (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (JJ TBP-associated) (NN factor)) (, ,) (NP (JJ eukaryotic) (NN elongation) (NN factor)) (CC and) (NP (NN _PROT2_) (CD _PROT2_))) (VP (VBD were) (VP (VBN up-regulated) (ADVP (RBR more) (IN than) (NP (CD 3.5) (NN fold)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Of) (NP (DT these) (CD 400))) (, ,) (NP (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (JJ TBP-associated) (NN factor)) (, ,) (NP (JJ eukaryotic) (NN elongation) (NN factor)) (CC and) (NP (NN _PROT_) (CD _PROT_))) (VP (VBD were) (VP (VBN up-regulated) (ADVP (RBR more) (IN than) (NP (CD 3.5) (NN fold)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Of) (NP (DT these) (CD 400))) (, ,) (NP (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (JJ TBP-associated) (NN factor)) (, ,) (NP (JJ eukaryotic) (NN elongation) (NN factor)) (CC and) (NP (NN _PROT2_) (CD _PROT2_))) (VP (VBD were) (VP (VBN up-regulated) (ADVP (RBR more) (IN than) (NP (CD 3.5) (NN fold)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Of) (NP (DT these) (CD 400))) (, ,) (NP (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (JJ TBP-associated) (NN factor)) (, ,) (NP (JJ eukaryotic) (NN elongation) (NN factor)) (CC and) (NP (NN _PROT2_) (CD _PROT2_))) (VP (VBD were) (VP (VBN up-regulated) (ADVP (RBR more) (IN than) (NP (CD 3.5) (NN fold)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Many)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN signaling) (NNS molecules)) (, ,) (PP (VBG including) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, _PROT_) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN protein) (NN phosphatase)))) (, ,)))) (VP (VBP regulate) (NP (NP (DT the) (NNS transporters)) (PP (IN for) (NP (JJ different) (NNS neurotransmitters)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Many)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN signaling) (NNS molecules)) (, ,) (PP (VBG including) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, _PROT2_) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN protein) (NN phosphatase)))) (, ,)))) (VP (VBP regulate) (NP (NP (DT the) (NNS transporters)) (PP (IN for) (NP (JJ different) (NNS neurotransmitters)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Many)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN signaling) (NNS molecules)) (, ,) (PP (VBG including) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, _PROT_) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN protein) (NN phosphatase)))) (, ,)))) (VP (VBP regulate) (NP (NP (DT the) (NNS transporters)) (PP (IN for) (NP (JJ different) (NNS neurotransmitters)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Many)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN signaling) (NNS molecules)) (, ,) (PP (VBG including) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, _PROT2_) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN protein) (NN phosphatase)))) (, ,)))) (VP (VBP regulate) (NP (NP (DT the) (NNS transporters)) (PP (IN for) (NP (JJ different) (NNS neurotransmitters)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Many)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN signaling) (NNS molecules)) (, ,) (PP (VBG including) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, _PROT_) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN protein) (NN phosphatase)))) (, ,)))) (VP (VBP regulate) (NP (NP (DT the) (NNS transporters)) (PP (IN for) (NP (JJ different) (NNS neurotransmitters)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Many)) (PP (IN of) (NP (NP (DT the) (JJ same) (NN signaling) (NNS molecules)) (, ,) (PP (VBG including) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, _PROT1_) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN protein) (NN phosphatase)))) (, ,)))) (VP (VBP regulate) (NP (NP (DT the) (NNS transporters)) (PP (IN for) (NP (JJ different) (NNS neurotransmitters)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (NN messenger) (NN RNA) (NN gene) (NN expression)) (PP (IN of) (NP (NP (JJ extracellular) (NN matrix) (NNS proteins)) (PRN (-LRB- -LRB-) (FRAG (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (-RRB- -RRB-)))))) (PP (IN across) (NP (NP (NN cell) (NNS passages)) (PRN (-LRB- -LRB-) (PP (NP (NP (QP (CD 3) (, ,) (CD 4) (, ,) (CD 5) (, ,) (CD 6) (, ,) (CD 10) (, ,) (CC and) (CD 12)) (JJ fornormal) (NN laminapropria)) (CC and) (NP (CD 3)) (, ,) (NP (CD 4)) (, ,) (NP (CD 5)) (, ,) (NP (CD 6)) (, ,) (CC and) (NP (CD 10))) (IN for) (NP (JJ tracheal) (NN scar))) (-RRB- -RRB-))))) (VP (VBD revealed) (NP (JJ varied) (NN growth) (NNS patterns))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Molecular) (NN cloning)) (PP (IN of) (NP (NP (NP (DT a) (JJ novel) (JJ human) (NN CC) (NN chemokine)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Previously)) (, ,) (NP (PRP we)) (VP (VBD mapped) (NP (NP (DT the) (JJ novel) (NN CC) (NN chemokine) (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN _PROT_)) (PP (TO to) (NP (NN chromosome) (NN 7q11.23)))) (PRN (-LRB- -LRB-) (NP (NP (NP (NP (NNP Nomiyama) (, ,) (NNP H.)) (, ,) (NP (NNP Osborne) (, ,) (NNP L.) (NNP R.)) (, ,) (NP (NNP Imai) (, ,) (NNP T.) (, ,) (NNP Kusuda)) (, ,) (NP (NNP J.) (, ,) (NNP Miura)) (, ,) (NP (NNP R.) (, ,) (NNP Tsui) (, ,) (NNP L.-C.)) (, ,) (CC and) (NP (NNP Yoshie))) (, ,) (NP (NN O)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1998)) (-RRB- -RRB-)) (NP (NNP Genomics) (CD 49) (, ,) (CD 339-340))) (-RRB- -RRB-)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Previously)) (, ,) (NP (PRP we)) (VP (VBD mapped) (NP (NP (DT the) (JJ novel) (NN CC) (NN chemokine) (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN _PROT2_)) (PP (TO to) (NP (NN chromosome) (NN 7q11.23)))) (PRN (-LRB- -LRB-) (NP (NP (NP (NP (NNP Nomiyama) (, ,) (NNP H.)) (, ,) (NP (NNP Osborne) (, ,) (NNP L.) (NNP R.)) (, ,) (NP (NNP Imai) (, ,) (NNP T.) (, ,) (NNP Kusuda)) (, ,) (NP (NNP J.) (, ,) (NNP Miura)) (, ,) (NP (NNP R.) (, ,) (NNP Tsui) (, ,) (NNP L.-C.)) (, ,) (CC and) (NP (NNP Yoshie))) (, ,) (NP (NN O)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1998)) (-RRB- -RRB-)) (NP (NNP Genomics) (CD 49) (, ,) (CD 339-340))) (-RRB- -RRB-)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Previously)) (, ,) (NP (PRP we)) (VP (VBD mapped) (NP (NP (DT the) (JJ novel) (NN CC) (NN chemokine) (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN _PROT2_)) (PP (TO to) (NP (NN chromosome) (NN 7q11.23)))) (PRN (-LRB- -LRB-) (NP (NP (NP (NP (NNP Nomiyama) (, ,) (NNP H.)) (, ,) (NP (NNP Osborne) (, ,) (NNP L.) (NNP R.)) (, ,) (NP (NNP Imai) (, ,) (NNP T.) (, ,) (NNP Kusuda)) (, ,) (NP (NNP J.) (, ,) (NNP Miura)) (, ,) (NP (NNP R.) (, ,) (NNP Tsui) (, ,) (NNP L.-C.)) (, ,) (CC and) (NP (NNP Yoshie))) (, ,) (NP (NN O)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1998)) (-RRB- -RRB-)) (NP (NNP Genomics) (CD 49) (, ,) (CD 339-340))) (-RRB- -RRB-)))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Prompted) (PP (IN by) (NP (DT this) (NN hypothesis)))) (, ,) (NP (PRP we)) (VP (VP (VBD analyzed) (NP (NP (DT the) (JJ genomic) (NN region)) (VP (VBG containing) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (NP (NN _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (CC and) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ novel) (NN CC) (NN chemokine)) (VP (VBN termed) (S (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Prompted) (PP (IN by) (NP (DT this) (NN hypothesis)))) (, ,) (NP (PRP we)) (VP (VP (VBD analyzed) (NP (NP (DT the) (JJ genomic) (NN region)) (VP (VBG containing) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (CC and) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ novel) (NN CC) (NN chemokine)) (VP (VBN termed) (S (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Prompted) (PP (IN by) (NP (DT this) (NN hypothesis)))) (, ,) (NP (PRP we)) (VP (VP (VBD analyzed) (NP (NP (DT the) (JJ genomic) (NN region)) (VP (VBG containing) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (CC and) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ novel) (NN CC) (NN chemokine)) (VP (VBN termed) (S (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Prompted) (PP (IN by) (NP (DT this) (NN hypothesis)))) (, ,) (NP (PRP we)) (VP (VP (VBD analyzed) (NP (NP (DT the) (JJ genomic) (NN region)) (VP (VBG containing) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (CC and) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ novel) (NN CC) (NN chemokine)) (VP (VBN termed) (S (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Prompted) (PP (IN by) (NP (DT this) (NN hypothesis)))) (, ,) (NP (PRP we)) (VP (VP (VBD analyzed) (NP (NP (DT the) (JJ genomic) (NN region)) (VP (VBG containing) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (CC and) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ novel) (NN CC) (NN chemokine)) (VP (VBN termed) (S (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (VBN Prompted) (PP (IN by) (NP (DT this) (NN hypothesis)))) (, ,) (NP (PRP we)) (VP (VP (VBD analyzed) (NP (NP (DT the) (JJ genomic) (NN region)) (VP (VBG containing) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))) (CC and) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ novel) (NN CC) (NN chemokine)) (VP (VBN termed) (S (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS genes)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN localized) (PP (IN within) (NP (NP (DT a) (NN region)) (PP (IN of) (NP (QP (RB approximately) (CD 40)) (NNS kilobases)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (JJ transient) (NN calcium) (NN mobilization)) (ADVP (RB specifically)) (PP (IN in) (NP (ADJP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -expressing)) (NN L1.2) (NNS cells))) (PP (IN with) (NP (NP (DT an) (NN EC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-)) (PP (IN of) (NP (CD 3) (NN nM))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (JJ transient) (NN calcium) (NN mobilization)) (ADVP (RB specifically)) (PP (IN in) (NP (ADJP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -expressing)) (NN L1.2) (NNS cells))) (PP (IN with) (NP (NP (DT an) (NN EC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-)) (PP (IN of) (NP (CD 3) (NN nM))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD induced) (NP (JJ transient) (NN calcium) (NN mobilization)) (ADVP (RB specifically)) (PP (IN in) (NP (ADJP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -expressing)) (NN L1.2) (NNS cells))) (PP (IN with) (NP (NP (DT an) (NN EC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-)) (PP (IN of) (NP (CD 3) (NN nM))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD competed) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (-LRB- -LRB-) (CD 125) (-RRB- -RRB-) (NN _PROT2_))) (PP (TO to) (NP (JJ _PROT_) (NN L1.2) (NNS cells)))) (PP (IN with) (NP (NP (DT an) (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-)) (PP (IN of) (NP (CD 13) (NN nM))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD competed) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (-LRB- -LRB-) (CD 125) (-RRB- -RRB-) (NN _PROT_))) (PP (TO to) (NP (JJ _PROT2_) (NN L1.2) (NNS cells)))) (PP (IN with) (NP (NP (DT an) (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-)) (PP (IN of) (NP (CD 13) (NN nM))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD competed) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (-LRB- -LRB-) (CD 125) (-RRB- -RRB-) (NN _PROT1_))) (PP (TO to) (NP (JJ _PROT2_) (NN L1.2) (NNS cells)))) (PP (IN with) (NP (NP (DT an) (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-)) (PP (IN of) (NP (CD 13) (NN nM))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Collectively)) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB yet)) (NP (NP (DT another) (JJ functional) (NN ligand)) (PP (IN for) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN potency)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN as) (NP (DT a) (NN _PROT2_) (NN ligand)))) (VP (VBZ seems) (, ,) (ADVP (RB however)) (, ,) (S (VP (TO to) (VP (VB be) (ADJP (ADJP (ADVP (RB approximately) (RB 10-fold)) (JJR less)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN potency)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN as) (NP (DT a) (NN _PROT_) (NN ligand)))) (VP (VBZ seems) (, ,) (ADVP (RB however)) (, ,) (S (VP (TO to) (VP (VB be) (ADJP (ADJP (ADVP (RB approximately) (RB 10-fold)) (JJR less)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN potency)) (PP (IN of) (NP (NN _PROT_))) (PP (IN as) (NP (DT a) (NN _PROT1_) (NN ligand)))) (VP (VBZ seems) (, ,) (ADVP (RB however)) (, ,) (S (VP (TO to) (VP (VB be) (ADJP (ADJP (ADVP (RB approximately) (RB 10-fold)) (JJR less)) (PP (IN than) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Identification)) (PP (IN of) (NP (NN _PROT1_)))) (VP (MD will) (ADVP (RB further)) (VP (VB promote) (NP (NP (PRP$ our) (NN understanding)) (PP (IN of) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NP (NN eosinophil) (NN trafficking)) (CC and) (NP (JJ other) (JJ _PROT2_) (JJ biological) (NNS phenomena)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT1_) (NN _PROT1_)) (JJ _PROT1_) (NN _PROT1_AND_PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT1_) (NN _PROT1_)) (JJ _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT1_) (NN _PROT1_)) (JJ _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT1_) (NN _PROT1_)) (JJ _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT_) (NN _PROT_)) (JJ _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT_) (NN _PROT_)) (JJ _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT_) (NN _PROT_)) (JJ _PROT_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT_) (NN _PROT_)) (JJ _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT_) (NN _PROT_)) (JJ _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Human) (NN _PROT_) (NN _PROT_)) (JJ _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (CC and) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NNS hepatocytes)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ human) (NN CC) (NN chemokine)) (VP (ADVP (RB selectively)) (VBN expressed) (PP (IN in) (NP (DT the) (NN liver))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ human) (NN CC) (NN chemokine)) (VP (ADVP (RB selectively)) (VBN expressed) (PP (IN in) (NP (DT the) (NN liver))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ human) (NN CC) (NN chemokine)) (VP (ADVP (RB selectively)) (VBN expressed) (PP (IN in) (NP (DT the) (NN liver))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN At) (NP (ADJP (RB relatively) (JJ high)) (NNS concentrations))) (, ,) (NP (NNS _PROT1_)) (VP (VBD induced) (NP (NP (NN calcium) (NN mobilization)) (CC and) (NP (NN chemotaxis))) (PP (IN via) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN At) (NP (ADJP (RB relatively) (JJ high)) (NNS concentrations))) (, ,) (NP (NNS _PROT1_)) (VP (VBD induced) (NP (NP (NN calcium) (NN mobilization)) (CC and) (NP (NN chemotaxis))) (PP (IN via) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN At) (NP (ADJP (RB relatively) (JJ high)) (NNS concentrations))) (, ,) (NP (NNS _PROT_)) (VP (VBD induced) (NP (NP (NN calcium) (NN mobilization)) (CC and) (NP (NN chemotaxis))) (PP (IN via) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBD induced) (NP (NN calcium) (NN mobilization)) (, ,) (CC but) (NP (JJ marginal) (NN chemotaxis)) (PP (IN via) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Consistently)) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (ADJP (RB relatively) (JJ low)) (NNS affinities))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Consistently)) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (ADJP (RB relatively) (JJ low)) (NNS affinities))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Consistently)) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (ADJP (RB relatively) (JJ low)) (NNS affinities))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Consistently)) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (ADJP (RB relatively) (JJ low)) (NNS affinities))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Consistently)) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (ADJP (RB relatively) (JJ low)) (NNS affinities))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Consistently)) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (ADJP (RB relatively) (JJ low)) (NNS affinities))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NNS _PROT1_))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VBD was) (ADJP (ADVP (RB much) (RBR less)) (JJ significant)))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN spite)) (PP (IN of) (NP (NP (PRP$ its) (NN binding)) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (NP (NN _PROT2_)) (VP (VBD was) (ADJP (JJ unable) (S (VP (TO to) (VP (VB inhibit) (NP (NP (NN infection)) (PP (IN of) (NP (DT an) (JJ R5-type) (NN HIV-1))) (PP (TO to) (NP (VBN activated) (JJ human) (JJ peripheral) (NN blood) (JJ mononuclear) (NNS cells)))) (PP (ADVP (RB even)) (IN at) (NP (JJ high) (NNS concentrations))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ new) (JJ low-affinity) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (, ,) (CC and) (VP (VBZ is) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NN liver) (NN parenchymal) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ new) (JJ low-affinity) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (, ,) (CC and) (VP (VBZ is) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NN liver) (NN parenchymal) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ new) (JJ low-affinity) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (, ,) (CC and) (VP (VBZ is) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NN liver) (NN parenchymal) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ new) (JJ low-affinity) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (, ,) (CC and) (VP (VBZ is) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NN liver) (NN parenchymal) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ new) (JJ low-affinity) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (, ,) (CC and) (VP (VBZ is) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NN liver) (NN parenchymal) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (JJ new) (JJ low-affinity) (JJ functional) (NN ligand)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (, ,) (CC and) (VP (VBZ is) (ADVP (RB constitutively)) (VP (VBN expressed) (PP (IN by) (NP (NN liver) (NN parenchymal) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ homodimeric) (NN _PROT1_) (NN _PROT1_)) (PP (IN _PROT1_) (NP (NP (JJ _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN by) (NP (NP (NN X-ray) (NN analysis)) (PP (TO to) (NP (CD 3.0) (NN A) (NN resolution))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ cellular) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ competes) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN gene) (NN product))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Tumour-suppressor) (NNS genes)) (, ,) (PP (JJ such) (IN as) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (, ,)) (VP (VBP are) (ADVP (RB widely)) (VP (VBN recognized) (PP (IN as) (S (VP (VBG being) (ADJP (JJ vital) (PP (IN in) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN tumour) (NN formation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBARQ (WHADVP (WRB How)) (SQ (NP (NN _PROT1_)) (VP (VBZ acts) (S (VP (TO to) (VP (VBP bring) (SBAR (IN about) (S (S (NP (DT this) (NN suppression)) (VP (VBZ is) (RB not) (ADJP (JJ clear)))) (CC but) (S (NP (CD one) (NN clue)) (VP (VBZ is) (SBAR (SBAR (IN that) (S (NP (DT the) (NN _PROT2_) (NN protein)) (VP (VBZ forms) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (DT the) (NN transforming) (NNS oncoproteins)) (PP (IN of) (NP (JJ several) (NN DNA) (NN tumour) (NNS viruses))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (CD two) (NNS regions)) (PP (IN of) (NP (NN _PROT_))) (ADJP (JJ essential) (PP (IN for) (NP (JJ such) (NN binding))))) (ADVP (RB frequently)) (VP (VBP contain) (NP (NP (NNS mutations)) (PP (IN in) (NP (NN tumour) (NNS cells)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBARQ (WHADVP (WRB How)) (SQ (NP (NN _PROT1_)) (VP (VBZ acts) (S (VP (TO to) (VP (VBP bring) (SBAR (IN about) (S (S (NP (DT this) (NN suppression)) (VP (VBZ is) (RB not) (ADJP (JJ clear)))) (CC but) (S (NP (CD one) (NN clue)) (VP (VBZ is) (SBAR (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VBZ forms) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (DT the) (NN transforming) (NNS oncoproteins)) (PP (IN of) (NP (JJ several) (NN DNA) (NN tumour) (NNS viruses))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (CD two) (NNS regions)) (PP (IN of) (NP (NN _PROT2_))) (ADJP (JJ essential) (PP (IN for) (NP (JJ such) (NN binding))))) (ADVP (RB frequently)) (VP (VBP contain) (NP (NP (NNS mutations)) (PP (IN in) (NP (NN tumour) (NNS cells)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBARQ (WHADVP (WRB How)) (SQ (NP (NN _PROT_)) (VP (VBZ acts) (S (VP (TO to) (VP (VBP bring) (SBAR (IN about) (S (S (NP (DT this) (NN suppression)) (VP (VBZ is) (RB not) (ADJP (JJ clear)))) (CC but) (S (NP (CD one) (NN clue)) (VP (VBZ is) (SBAR (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VBZ forms) (NP (NP (NNS complexes)) (PP (IN with) (NP (NP (DT the) (NN transforming) (NNS oncoproteins)) (PP (IN of) (NP (JJ several) (NN DNA) (NN tumour) (NNS viruses))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (CD two) (NNS regions)) (PP (IN of) (NP (NN _PROT2_))) (ADJP (JJ essential) (PP (IN for) (NP (JJ such) (NN binding))))) (ADVP (RB frequently)) (VP (VBP contain) (NP (NP (NNS mutations)) (PP (IN in) (NP (NN tumour) (NNS cells)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (CD one)) (PP (IN such) (NP (NP (JJ human) (JJ cellular) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (PP (IN of) (NP (NP (NP (JJ relative) (JJ molecular) (NN mass) (NN 46,000)) (PRN (-LRB- -LRB-) (NP (NN 46K)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (CD one)) (PP (IN such) (NP (NP (JJ human) (JJ cellular) (JJ _PROT1_) (NN _PROT_)) (PP (IN of) (NP (NP (NP (JJ relative) (JJ molecular) (NN mass) (NN 46,000)) (PRN (-LRB- -LRB-) (NP (NN 46K)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (CD one)) (PP (IN such) (NP (NP (JJ human) (JJ cellular) (JJ _PROT1_) (NN _PROT1_)) (PP (IN of) (NP (NP (NP (JJ relative) (JJ molecular) (NN mass) (NN 46,000)) (PRN (-LRB- -LRB-) (NP (NN 46K)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_) (NN _PROT2_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT2_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT2_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT2_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT2_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT2_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT2_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT1_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT2_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT1_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT1_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT2_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT1_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT1_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT2_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT1_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT2_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT1_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT1_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT2_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT1_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (NNS lines)) (PP (IN of) (NP (NN evidence)))) (VP (VBP support) (NP (DT the) (NN notion) (SBAR (IN that) (S (S (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_))) (VP (VBP have) (NP (JJ homologous) (NN _PROT_) (NNS properties)))) (: :) (S (ADVP (RB first)) (, ,) (NP (NP (JJ several) (VBN mutated) (NN _PROT_) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBD failed) (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NN T))))))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NN _PROT_)))))) (: ;) (CC and) (S (ADVP (RB second)) (, ,) (NP (CC both) (NP (NN T) (NN antigen)) (CC and) (NP (NP (NN T) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN amino) (NNS acids) (CD 101-118)) (-RRB- -RRB-)))) (VP (VBD were) (ADJP (JJ able) (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (NN _PROT1_))) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ apparent) (NN targeting)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN interaction))) (PP (IN by) (NP (NP (NNS oncoproteins)) (PP (IN of) (NP (NN DNA) (NN tumour) (NNS viruses)))))) (ADVP (RB strongly)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN formation)) (PP (IN of) (NP (DT this) (NN complex)))) (VP (VBZ is) (ADVP (RB functionally)) (ADJP (JJ important))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN of) (NP (DT the) (NN protein)))) (VP (VBP _PROT1_) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))) (, ,) (SBAR (IN as) (S (VP (VBN revealed) (PP (IN by) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN specificity)) (PP (IN of) (NP (NN intehraction))) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN confirmed) (PP (IN by) (NP (NP (DT an) (ADJP (FW in) (FW vitro)) (NN binding) (NN assay)) (VP (VBG using) (NP (JJ recombinant) (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transfection)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD increased) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN expression)) (PP (JJ relative) (TO to) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN mock) (NN vector))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transfection)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD increased) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (NN expression)) (PP (JJ relative) (TO to) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN mock) (NN vector))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transfection)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD increased) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN expression)) (PP (JJ relative) (TO to) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN mock) (NN vector))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transfection)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD increased) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (NN expression)) (PP (JJ relative) (TO to) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN mock) (NN vector))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transfection)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD increased) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN expression)) (PP (JJ relative) (TO to) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN mock) (NN vector))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transfection)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NN COS) (NNS cells)))) (VP (VBD increased) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN expression)) (PP (JJ relative) (TO to) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN mock) (NN vector))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (NN _PROT2_)))))) (VP (VBZ reveals) (NP (NP (JJ hydrophobic) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN dimerization) (CC and/or) (NN anchoring) (NN _PROT_) (NN _PROT_)) (PP (TO to) (NP (DT the) (NN cytoskeleton))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN _PROT_)))))) (VP (VBZ reveals) (NP (NP (JJ hydrophobic) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN dimerization) (CC and/or) (NN anchoring) (NN _PROT_) (NN _PROT_)) (PP (TO to) (NP (DT the) (NN cytoskeleton))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN _PROT_)))))) (VP (VBZ reveals) (NP (NP (JJ hydrophobic) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN dimerization) (CC and/or) (NN anchoring) (NN _PROT2_) (NN _PROT2_)) (PP (TO to) (NP (DT the) (NN cytoskeleton))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN _PROT1_)))))) (VP (VBZ reveals) (NP (NP (JJ hydrophobic) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN dimerization) (CC and/or) (NN anchoring) (NN _PROT_) (NN _PROT_)) (PP (TO to) (NP (DT the) (NN cytoskeleton))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN _PROT1_)))))) (VP (VBZ reveals) (NP (NP (JJ hydrophobic) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN dimerization) (CC and/or) (NN anchoring) (NN _PROT2_) (NN _PROT2_)) (PP (TO to) (NP (DT the) (NN cytoskeleton))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN _PROT_)))))) (VP (VBZ reveals) (NP (NP (JJ hydrophobic) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN dimerization) (CC and/or) (NN anchoring) (NN _PROT2_) (NN _PROT2_)) (PP (TO to) (NP (DT the) (NN cytoskeleton))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NNS neurons))) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (VP (VBN sequestered) (PP (IN in) (NP (DT the) (JJ dendritic) (NN cytoskeleton))) (SBAR (IN because) (S (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ is) (ADVP (RB tightly)) (VP (VBN bound) (PP (IN by) (NP (NP (NP (DT A) (NN Kinase) (NN Anchor)) (NNS Proteins)) (PRN (-LRB- -LRB-) (NP (NNS AKAPs)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NNS neurons))) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ is) (VP (VBN sequestered) (PP (IN in) (NP (DT the) (JJ dendritic) (NN cytoskeleton))) (SBAR (IN because) (S (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ is) (ADVP (RB tightly)) (VP (VBN bound) (PP (IN by) (NP (NP (NP (DT A) (NN Kinase) (NN Anchor)) (NNS Proteins)) (PRN (-LRB- -LRB-) (NP (NNS AKAPs)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NNS neurons))) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ is) (VP (VBN sequestered) (PP (IN in) (NP (DT the) (JJ dendritic) (NN cytoskeleton))) (SBAR (IN because) (S (NP (NP (NP (DT the) (JJ regulatory) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ is) (ADVP (RB tightly)) (VP (VBN bound) (PP (IN by) (NP (NP (NP (DT A) (NN Kinase) (NN Anchor)) (NNS Proteins)) (PRN (-LRB- -LRB-) (NP (NNS AKAPs)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ prototypic) (JJ neuronal) (NN anchor) (NN protein) (NN _PROT1_)) (VP (VBZ has) (NP (DT a) (JJ COOH-terminal) (JJ 22-residue) (NN _PROT2_) (NN _PROT2_) (NN binding) (-LRB- -LRB-) (NN tethering) (-RRB- -RRB-) (NN site)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (, ,) (NP (JJ recombinant) (NN protein) (NN expression)) (, ,) (CC and) (NP (JJ physicochemical) (NN characterization))) (VP (VBD were) (VP (VBN used) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (JJ structural) (NN basis)) (PP (IN for) (NP (NP (DT the) (NP (NP (NN homodimerization)) (CC and) (NP (NN _PROT1_))) (NN binding) (NNS activities)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Substitution)) (PP (IN of) (NP (NN Ala))) (PP (IN for) (NP (NP (NN Leu13)) (CC or) (NP (NN Phe36))))) (VP (VBZ generates) (NP (NP (JJ monomeric) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (SBAR (WHNP (WDT that)) (S (ADVP (RB cannot)) (VP (VBP bind) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP are) (RB not) (ADJP (JJ due) (PP (TO to) (NP (JJ general) (NN misfolding)))) (SBAR (IN since) (S (NP (JJ mutant) (NN _PROT1_) (NN _PROT1_) (NNS monomers)) (VP (VP (VBP bind) (NP (NN cAMP))) (CC and) (VP (VBP inhibit) (NP (NP (DT the) (JJ catalytic) (NN subunit)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN with) (NP (NP (DT the) (NP (JJ same) (NN affinity)) (CC and) (NP (NN efficacy))) (PP (IN as) (NP (JJ wild-type) (NN _PROT_) (NN _PROT_) (NNS dimers)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP are) (RB not) (ADJP (JJ due) (PP (TO to) (NP (JJ general) (NN misfolding)))) (SBAR (IN since) (S (NP (JJ mutant) (NN _PROT1_) (NN _PROT1_) (NNS monomers)) (VP (VP (VBP bind) (NP (NN cAMP))) (CC and) (VP (VBP inhibit) (NP (NP (DT the) (JJ catalytic) (NN subunit)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NP (JJ same) (NN affinity)) (CC and) (NP (NN efficacy))) (PP (IN as) (NP (JJ wild-type) (NN _PROT2_) (NN _PROT2_) (NNS dimers)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP are) (RB not) (ADJP (JJ due) (PP (TO to) (NP (JJ general) (NN misfolding)))) (SBAR (IN since) (S (NP (JJ mutant) (NN _PROT_) (NN _PROT_) (NNS monomers)) (VP (VP (VBP bind) (NP (NN cAMP))) (CC and) (VP (VBP inhibit) (NP (NP (DT the) (JJ catalytic) (NN subunit)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NP (JJ same) (NN affinity)) (CC and) (NP (NN efficacy))) (PP (IN as) (NP (JJ wild-type) (NN _PROT2_) (NN _PROT2_) (NNS dimers)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Evidently)) (, ,) (NP (NP (JJ large) (JJ hydrophobic) (JJ side) (NNS chains)) (PP (IN of) (NP (NP (NN Leu13)) (CC and) (NP (NN Phe36))))) (VP (VBP play) (NP (JJ pivotal) (NNS roles)) (PP (IN in) (S (VP (VBG stabilizing) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NNS interactions))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ secondary) (NN consequence)) (PP (IN of) (NP (NN destabilizing) (NN _PROT1_) (NN _PROT1_) (NNS dimers)))) (VP (VBZ is) (NP (NP (DT the) (NN loss)) (PP (IN of) (NP (JJ intracellular) (NN targeting/anchoring) (NN capacity)))) (SBAR (IN because) (S (NP (NNS monomers)) (VP (VBP fail) (S (VP (TO to) (VP (VB bind) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Other) (JJ NH2-terminal) (NNS residues)) (ADVP (RB directly)) (VP (VBP modulate) (NP (NP (DT the) (NN affinity)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NNS dimers))) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN tethering) (NN site)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (NN Val20-Leu21))) (PP (IN with) (NP (NN Ala-Ala)))) (VP (VBD produced) (NP (NP (DT a) (JJ dimeric) (NN _PROT1_) (NN _PROT1_) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (NN _PROT2_)) (ADJP (QP (RB approximately) (CD 4)) (NN %))) (ADVP (RB as) (RB avidly)) (PP (IN as) (NP (JJ wild-type) (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (NN Val20-Leu21))) (PP (IN with) (NP (NN Ala-Ala)))) (VP (VBD produced) (NP (NP (DT a) (JJ dimeric) (NN _PROT1_) (NN _PROT1_) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (NN _PROT_)) (ADJP (QP (RB approximately) (CD 4)) (NN %))) (ADVP (RB as) (RB avidly)) (PP (IN as) (NP (JJ wild-type) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Replacement)) (PP (IN of) (NP (NN Val20-Leu21))) (PP (IN with) (NP (NN Ala-Ala)))) (VP (VBD produced) (NP (NP (DT a) (JJ dimeric) (NN _PROT_) (NN _PROT_) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (NN _PROT1_)) (ADJP (QP (RB approximately) (CD 4)) (NN %))) (ADVP (RB as) (RB avidly)) (PP (IN as) (NP (JJ wild-type) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (NP (DT a) (NN protein) (NN kinase)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NN UV) (NN light)) (CC and) (NP (NN _PROT2_)))))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ binds)) (CC and) (VP (VBZ phosphorylates) (NP (DT the) (NN _PROT_) (NN activation) (NN domain))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (NP (DT a) (NN protein) (NN kinase)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NN UV) (NN light)) (CC and) (NP (NN _PROT_)))))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ binds)) (CC and) (VP (VBZ phosphorylates) (NP (DT the) (NN _PROT2_) (NN activation) (NN domain))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (NP (DT a) (NN protein) (NN kinase)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NN UV) (NN light)) (CC and) (NP (NN _PROT1_)))))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ binds)) (CC and) (VP (VBZ phosphorylates) (NP (DT the) (NN _PROT2_) (NN activation) (NN domain))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN ultraviolet) (-LRB- -LRB-) (NN UV) (-RRB- -RRB-) (NN response)) (PP (IN of) (NP (JJ mammalian) (NNS cells)))) (VP (VBZ is) (VP (VBN characterized) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (CC and) (ADJP (JJ selective))) (NN increase)) (PP (IN in) (NP (NP (NN gene) (NN expression)) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN effect)) (PP (IN on) (NP (NN _PROT1_) (JJ transcriptional) (NN activity)))) (VP (VBZ results) (, ,) (PP (IN in) (NP (NN part))) (, ,) (PP (IN from) (NP (NP (VBN enhanced) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (JJ NH2-terminal) (NN activation) (NN domain))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP describe) (NP (NP (NP (DT the) (JJ molecular) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ distant) (NN relative)) (PP (IN of) (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_)) (NN group))) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (JJ dual) (NN phosphorylation)) (PP (IN at) (NP (NP (NN Thr)) (CC and) (NP (NN Tyr)))))) (PP (IN during) (NP (DT the) (NN UV) (NN response)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Significantly)) (, ,) (NP (NN _PROT1_)) (ADVP (RB partially)) (VP (VP (VBZ activates) (NP (NN _PROT2_))) (CC and) (VP (VBZ potentiates) (NP (NP (DT the) (NN activation)) (VP (VBN caused) (PP (IN by) (NP (NN UV)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN transactivation) (NN domain)))) (CC and) (VP (VBZ phosphorylates) (NP (PRP it)) (PP (IN on) (NP (NP (NN Ser-63)) (CC and) (NP (NN Ser-73))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN ligand)) (PP (IN for) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein) (NN ligand)) (PP (IN for) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (VP (VBZ has) (VP (VBN been) (VP (VBN isolated) (PP (IN by) (S (VP (VBG using) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN receptor)))) (PP (IN as) (NP (DT an) (NN affinity) (NN reagent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein) (NN ligand)) (PP (IN for) (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (VP (VBZ has) (VP (VBN been) (VP (VBN isolated) (PP (IN by) (S (VP (VBG using) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN receptor)))) (PP (IN as) (NP (DT an) (NN affinity) (NN reagent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN protein) (NN ligand)) (PP (IN for) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBZ has) (VP (VBN been) (VP (VBN isolated) (PP (IN by) (S (VP (VBG using) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN receptor)))) (PP (IN as) (NP (DT an) (NN affinity) (NN reagent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Subsequently)) (, ,) (NP (NP (NNS supernatants)) (PP (IN from) (NP (VBN selected) (NN cell) (NNS lines)))) (VP (VBD were) (VP (VBN fractionated) (ADVP (RB directly)) (PP (IN by) (NP (NN receptor) (NN affinity) (NN chromatography))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (DT the) (JJ single-step) (NN purification)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN protein)) (VP (ADVP (RB previously)) (VBN identified) (PP (IN as) (NP (NP (DT the) (NN product)) (PP (IN of) (NP (NP (DT an) (JJ early) (NN response) (NN gene)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (JJ recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (NN autophosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (NP (JJ intact) (NNS cells))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (S (NP (NN _PROT_)) (VP (VBG being) (NP (NP (DT an) (JJ authentic) (NN ligand)) (PP (IN for) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (JJ recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (NN autophosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ intact) (NNS cells))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (S (NP (NN _PROT2_)) (VP (VBG being) (NP (NP (DT an) (JJ authentic) (NN ligand)) (PP (IN for) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (JJ recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (NN autophosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ intact) (NNS cells))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (S (NP (NN _PROT_)) (VP (VBG being) (NP (NP (DT an) (JJ authentic) (NN ligand)) (PP (IN for) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (JJ recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (NN autophosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ intact) (NNS cells))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (S (NP (NN _PROT2_)) (VP (VBG being) (NP (NP (DT an) (JJ authentic) (NN ligand)) (PP (IN for) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (JJ recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (NN autophosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ intact) (NNS cells))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (S (NP (NN _PROT_)) (VP (VBG being) (NP (NP (DT an) (JJ authentic) (NN ligand)) (PP (IN for) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (JJ recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (NN autophosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ intact) (NNS cells))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (S (NP (NN _PROT1_)) (VP (VBG being) (NP (NP (DT an) (JJ authentic) (NN ligand)) (PP (IN for) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (JJ large) (NN orphan) (NN receptor) (NN protein-tyrosine) (NN kinase) (NN family)) (VP (VBN headed) (PP (IN by) (NP (NN EPH))))))))) (, ,) (CC and) (S (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NNS ligands)) (PP (IN for) (NP (NP (JJ other) (NNS members)) (PP (IN of) (NP (DT this) (NN family)))))) (VP (VP (MD will) (VP (VB be) (ADJP (JJ related) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC and) (VP (MD can) (VP (VB be) (VP (VBN isolated) (PP (IN in) (NP (DT the) (JJ same) (NN way)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN SH2/SH3) (JJ domain-containing) (NN protein) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ tyrosine-phosphorylated) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_)) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN insulin) (NN control)) (PP (IN of) (NP (NN _PROT_) (NN signalling))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN SH2/SH3) (JJ domain-containing) (NN protein) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ tyrosine-phosphorylated) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_)) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN insulin) (NN control)) (PP (IN of) (NP (NN _PROT_) (NN signalling))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN SH2/SH3) (JJ domain-containing) (NN protein) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ tyrosine-phosphorylated) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_)) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN insulin) (NN control)) (PP (IN of) (NP (NN _PROT2_) (NN signalling))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN SH2/SH3) (JJ domain-containing) (NN protein) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ tyrosine-phosphorylated) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_)) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN insulin) (NN control)) (PP (IN of) (NP (NN _PROT_) (NN signalling))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN SH2/SH3) (JJ domain-containing) (NN protein) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ tyrosine-phosphorylated) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN insulin) (NN control)) (PP (IN of) (NP (NN _PROT2_) (NN signalling))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN SH2/SH3) (JJ domain-containing) (NN protein) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ tyrosine-phosphorylated) (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (: :) (NP (NP (NNS implications)) (PP (IN for) (NP (NP (NN insulin) (NN control)) (PP (IN of) (NP (NN _PROT2_) (NN signalling))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ small) (NN protein)) (VP (VBG comprising) (NP (NP (CD one) (NN SH2) (NN domain)) (CC and) (NP (CD two) (NN SH3) (NNS domains))))) (, ,)) (VP (VBZ represents) (NP (NP (DT the) (JJ human) (NN homologue)) (PP (IN of) (NP (NP (DT the) (FW Caenorhabditis) (FW elegans) (NN protein)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (DT a) (ADJP (RB highly) (VBN conserved)) (NN mechanism)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (NN _PROT_) (NN signalling)) (PP (IN by) (NP (NN receptor) (NN tyrosine) (NNS kinases)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (DT a) (ADJP (RB highly) (VBN conserved)) (NN mechanism)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (NN _PROT2_) (NN signalling)) (PP (IN by) (NP (NN receptor) (NN tyrosine) (NNS kinases)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (DT a) (ADJP (RB highly) (VBN conserved)) (NN mechanism)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (NN _PROT2_) (NN signalling)) (PP (IN by) (NP (NN receptor) (NN tyrosine) (NNS kinases)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN report))) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ forms) (NP (NP (DT a) (JJ stable) (NN complex)) (PP (IN with) (NP (CD two) (JJ tyrosine-phosphorylated) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CD One) (NN protein)) (VP (VBZ is) (NP (DT the) (JJ major) (NN insulin) (NN receptor) (NN substrate) (NN _PROT1_)))) (CC and) (S (NP (DT the) (JJ second)) (VP (VBZ is) (NP (NP (DT the) (NN SH2) (JJ domain-containing) (JJ oncogenic) (NN protein)) (, ,) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT1_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT these) (CD two) (NNS proteins))))) (VP (VP (VBP require) (NP (NP (NN ligand) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (PP (TO to) (NP (NP (NNS phosphotyrosines)) (PP (IN on) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT2_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT2_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT2_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN tyrosine-phosphorylated) (PP (IN after) (NP (NN _PROT1_) (NN stimulation))) (, ,) (S (VP (VBG implying) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (RB not) (NP (NP (DT a) (NN substrate)) (PP (IN for) (NP (DT the) (NN insulin) (NN receptor)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ short) (NN sequence) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN YV/IN)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (JJ high) (NN affinity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ short) (NN sequence) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN YV/IN)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (JJ high) (NN affinity)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ short) (NN sequence) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN YV/IN)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (JJ high) (NN affinity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ short) (NN sequence) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN YV/IN)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (JJ high) (NN affinity)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ short) (NN sequence) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN YV/IN)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (JJ high) (NN affinity)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ short) (NN sequence) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN YV/IN)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (DT the) (NN SH2) (NN domain)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (JJ high) (NN affinity)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (NP (JJ distinct) (ADJP (NN tyrosine) (JJ phosphorylated)) (NNS regions)) (PP (IN on) (NP (DT the) (JJ same) (NN _PROT_) (NN molecule))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN mechanism)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN _PROT_)) (VP (MD could) (VP (VB provide) (NP (NP (DT the) (NN core)) (PP (IN for) (NP (DT a) (JJ large) (NN signalling) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (NP (JJ distinct) (ADJP (NN tyrosine) (JJ phosphorylated)) (NNS regions)) (PP (IN on) (NP (DT the) (JJ same) (NN _PROT2_) (NN molecule))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN mechanism)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN _PROT_)) (VP (MD could) (VP (VB provide) (NP (NP (DT the) (NN core)) (PP (IN for) (NP (DT a) (JJ large) (NN signalling) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (NP (JJ distinct) (ADJP (NN tyrosine) (JJ phosphorylated)) (NNS regions)) (PP (IN on) (NP (DT the) (JJ same) (NN _PROT_) (NN molecule))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN mechanism)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN _PROT2_)) (VP (MD could) (VP (VB provide) (NP (NP (DT the) (NN core)) (PP (IN for) (NP (DT a) (JJ large) (NN signalling) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (NP (JJ distinct) (ADJP (NN tyrosine) (JJ phosphorylated)) (NNS regions)) (PP (IN on) (NP (DT the) (JJ same) (NN _PROT2_) (NN molecule))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN mechanism)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN _PROT_)) (VP (MD could) (VP (VB provide) (NP (NP (DT the) (NN core)) (PP (IN for) (NP (DT a) (JJ large) (NN signalling) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (NP (JJ distinct) (ADJP (NN tyrosine) (JJ phosphorylated)) (NNS regions)) (PP (IN on) (NP (DT the) (JJ same) (NN _PROT_) (NN molecule))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN mechanism)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN _PROT2_)) (VP (MD could) (VP (VB provide) (NP (NP (DT the) (NN core)) (PP (IN for) (NP (DT a) (JJ large) (NN signalling) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_))) (VP (MD can) (ADVP (RB simultaneously)) (VP (VB bind) (NP (JJ distinct) (ADJP (NN tyrosine) (JJ phosphorylated)) (NNS regions)) (PP (IN on) (NP (DT the) (JJ same) (NN _PROT1_) (NN molecule))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (NN mechanism)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN _PROT2_)) (VP (MD could) (VP (VB provide) (NP (NP (DT the) (NN core)) (PP (IN for) (NP (DT a) (JJ large) (NN signalling) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN insulin) (NN stimulation)) (VP (VBZ leads) (PP (TO to) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ multiple) (JJ protein--protein) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (CD two) (NNS targets)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN insulin) (NN stimulation)) (VP (VBZ leads) (PP (TO to) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ multiple) (JJ protein--protein) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (CD two) (NNS targets)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (NP (NP (DT a) (NN model)) (SBAR (WHADVP (WRB whereby)) (S (NP (NN insulin) (NN stimulation)) (VP (VBZ leads) (PP (TO to) (NP (NP (NN formation)) (PP (IN of) (NP (NP (JJ multiple) (JJ protein--protein) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (CD two) (NNS targets)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ general) (NN transcription) (NN factor) (NN _PROT1_)) (VP (VP (VBZ nucleates) (NP (NN initiation) (NN complex) (NN formation)) (PP (IN through) (NP (JJ direct) (NN core) (NN promoter) (NN binding)))) (, ,) (VP (VBZ commits) (NP (NP (NNS promoters)) (PP (IN within) (NP (NP (NN chromatin)) (PP (TO to) (NP (NN transcription))))))) (, ,) (CC and) (VP (VBZ mediates) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NP (JJ transcriptional) (NNS activators)) (, ,) (NP (NP (DT a) (NN phenomenon)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (VP (VB correlate) (PP (IN with) (NP (NP (VBN enhanced) (NN _PROT2_) (NN recruitment)) (CC or) (NP (NP (JJ conformational) (NNS changes)) (PP (IN in) (NP (JJ _PROT_) (NNS complexes))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ general) (NN transcription) (NN factor) (NN _PROT1_)) (VP (VP (VBZ nucleates) (NP (NN initiation) (NN complex) (NN formation)) (PP (IN through) (NP (JJ direct) (NN core) (NN promoter) (NN binding)))) (, ,) (VP (VBZ commits) (NP (NP (NNS promoters)) (PP (IN within) (NP (NP (NN chromatin)) (PP (TO to) (NP (NN transcription))))))) (, ,) (CC and) (VP (VBZ mediates) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NP (JJ transcriptional) (NNS activators)) (, ,) (NP (NP (DT a) (NN phenomenon)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (VP (VB correlate) (PP (IN with) (NP (NP (VBN enhanced) (NN _PROT_) (NN recruitment)) (CC or) (NP (NP (JJ conformational) (NNS changes)) (PP (IN in) (NP (JJ _PROT2_) (NNS complexes))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ general) (NN transcription) (NN factor) (NN _PROT_)) (VP (VP (VBZ nucleates) (NP (NN initiation) (NN complex) (NN formation)) (PP (IN through) (NP (JJ direct) (NN core) (NN promoter) (NN binding)))) (, ,) (VP (VBZ commits) (NP (NP (NNS promoters)) (PP (IN within) (NP (NP (NN chromatin)) (PP (TO to) (NP (NN transcription))))))) (, ,) (CC and) (VP (VBZ mediates) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NP (JJ transcriptional) (NNS activators)) (, ,) (NP (NP (DT a) (NN phenomenon)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (VP (VB correlate) (PP (IN with) (NP (NP (VBN enhanced) (NN _PROT1_) (NN recruitment)) (CC or) (NP (NP (JJ conformational) (NNS changes)) (PP (IN in) (NP (JJ _PROT2_) (NNS complexes))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Molecular) (NNS studies)) (PP (IN of) (NP (DT the) (JJ multiprotein) (NN _PROT1_) (NN complex)))) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ primary) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (JJ TBP-associated) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (SBAR (IN with) (S (VP (CC and) (VP (VBP mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NNS activators)) (CC and) (NP (JJ intersubunit) (NNS interactions)))))) (CC but) (VP (VBP have) (S (VP (VBD yielded) (NP (NP (NP (ADJP (RB relatively) (JJ little)) (NN insight)) (PP (IN into) (NP (NP (DT the) (JJ structural) (NN organization)) (PP (IN of) (NP (DT the) (NN complex)))))) (CC or) (NP (NP (DT the) (JJ actual) (NN mechanism)) (PP (IN of) (NP (JJ transcriptional) (NN activation))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Molecular) (NNS studies)) (PP (IN of) (NP (DT the) (JJ multiprotein) (NN _PROT1_) (NN complex)))) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ primary) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (JJ TBP-associated) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (SBAR (IN with) (S (VP (CC and) (VP (VBP mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NNS activators)) (CC and) (NP (JJ intersubunit) (NNS interactions)))))) (CC but) (VP (VBP have) (S (VP (VBD yielded) (NP (NP (NP (ADJP (RB relatively) (JJ little)) (NN insight)) (PP (IN into) (NP (NP (DT the) (JJ structural) (NN organization)) (PP (IN of) (NP (DT the) (NN complex)))))) (CC or) (NP (NP (DT the) (JJ actual) (NN mechanism)) (PP (IN of) (NP (JJ transcriptional) (NN activation))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Molecular) (NNS studies)) (PP (IN of) (NP (DT the) (JJ multiprotein) (NN _PROT_) (NN complex)))) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ primary) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NP (JJ TBP-associated) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VBP interact) (SBAR (IN with) (S (VP (CC and) (VP (VBP mediate) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NNS activators)) (CC and) (NP (JJ intersubunit) (NNS interactions)))))) (CC but) (VP (VBP have) (S (VP (VBD yielded) (NP (NP (NP (ADJP (RB relatively) (JJ little)) (NN insight)) (PP (IN into) (NP (NP (DT the) (JJ structural) (NN organization)) (PP (IN of) (NP (DT the) (NN complex)))))) (CC or) (NP (NP (DT the) (JJ actual) (NN mechanism)) (PP (IN of) (NP (JJ transcriptional) (NN activation))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP present) (NP (NP (JJ biochemical) (NN evidence)) (PP (IN for) (NP (NP (DT the) (JJ structural) (NN relevance)) (PP (IN of) (NP (NP (NN histone) (NNS homologies)) (PP (IN in) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NNS subunits)) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP present) (NP (NP (JJ biochemical) (NN evidence)) (PP (IN for) (NP (NP (DT the) (JJ structural) (NN relevance)) (PP (IN of) (NP (NP (NN histone) (NNS homologies)) (PP (IN in) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NNS subunits)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP present) (NP (NP (JJ biochemical) (NN evidence)) (PP (IN for) (NP (NP (DT the) (JJ structural) (NN relevance)) (PP (IN of) (NP (NP (NN histone) (NNS homologies)) (PP (IN in) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NNS subunits)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP present) (NP (NP (JJ biochemical) (NN evidence)) (PP (IN for) (NP (NP (DT the) (JJ structural) (NN relevance)) (PP (IN of) (NP (NP (NN histone) (NNS homologies)) (PP (IN in) (NP (NP (DT the) (JJ human) (NN _PROT_) (NNS subunits)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP present) (NP (NP (JJ biochemical) (NN evidence)) (PP (IN for) (NP (NP (DT the) (JJ structural) (NN relevance)) (PP (IN of) (NP (NP (NN histone) (NNS homologies)) (PP (IN in) (NP (NP (DT the) (JJ human) (NN _PROT_) (NNS subunits)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP present) (NP (NP (JJ biochemical) (NN evidence)) (PP (IN for) (NP (NP (DT the) (JJ structural) (NN relevance)) (PP (IN of) (NP (NP (NN histone) (NNS homologies)) (PP (IN in) (NP (NP (DT the) (JJ human) (NN _PROT_) (NNS subunits)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (ADVP (RB Together)) (IN with) (NP (NP (NP (NNS analyses)) (PP (IN of) (NP (JJ native) (NN _PROT1_) (NNS complexes)))) (CC and) (NP (VBG accompanying) (JJ crystallographic) (NNS studies)))) (, ,) (NP (DT the) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (NN histone) (JJ octamer-like) (NN TAF) (NN complex)) (PP (IN within) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (NN kinase)) (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ pleiotropic) (JJ biological) (NNS activities)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (PRP$ its) (NN type) (NN I) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ pleiotropic) (JJ biological) (NNS activities)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (PRP$ its) (NN type) (NN I) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ pleiotropic) (JJ biological) (NNS activities)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBP are) (VP (VBN mediated) (PP (IN by) (NP (NP (PRP$ its) (NN type) (NN I) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (DT the) (NN ligand)) (VP (VBZ binds)))) (, ,) (NP (NN _PROT1_)) (VP (VBZ initiates) (NP (NP (DT a) (NN signaling) (NN cascade)) (SBAR (WHNP (WDT that)) (S (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (DT the) (NN transcription) (NN regulator) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (DT the) (NN ligand)) (VP (VBZ binds)))) (, ,) (NP (NN _PROT1_)) (VP (VBZ initiates) (NP (NP (DT a) (NN signaling) (NN cascade)) (SBAR (WHNP (WDT that)) (S (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (DT the) (NN transcription) (NN regulator) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (DT the) (NN ligand)) (VP (VBZ binds)))) (, ,) (NP (NN _PROT_)) (VP (VBZ initiates) (NP (NP (DT a) (NN signaling) (NN cascade)) (SBAR (WHNP (WDT that)) (S (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (DT the) (NN transcription) (NN regulator) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (NN protein) (NN kinase)) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN purified)))) (, ,) (CC and) (S (NP (PRP$ its) (JJ complementary) (NN DNA)) (VP (VBD was) (ADVP (RB molecularly)) (VP (VBN cloned))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (NN protein) (NN kinase)) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN purified)))) (, ,) (CC and) (S (NP (PRP$ its) (JJ complementary) (NN DNA)) (VP (VBD was) (ADVP (RB molecularly)) (VP (VBN cloned))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (NN protein) (NN kinase)) (VP (VBN designated) (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBD was) (VP (VBN purified)))) (, ,) (CC and) (S (NP (PRP$ its) (JJ complementary) (NN DNA)) (VP (VBD was) (ADVP (RB molecularly)) (VP (VBN cloned))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (NP (NP (JJ human) (JJ embryonic) (NN kidney)) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN cell) (NN line) (CD 293)) (-RRB- -RRB-))) (NP (NP (NN over-expressing) (NN _PROT1_)) (CC or) (NP (NN HeLa) (NNS cells)))) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NN _PROT2_))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB rapidly)) (VP (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex)))) (CC and) (VP (VBD was) (VP (VBN phosphorylated))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (NP (NP (JJ human) (JJ embryonic) (NN kidney)) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN cell) (NN line) (CD 293)) (-RRB- -RRB-))) (NP (NP (NN over-expressing) (NN _PROT1_)) (CC or) (NP (NN HeLa) (NNS cells)))) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NN _PROT_))))))) (, ,) (NP (NN _PROT2_)) (ADVP (RB rapidly)) (VP (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex)))) (CC and) (VP (VBD was) (VP (VBN phosphorylated))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (NP (NP (JJ human) (JJ embryonic) (NN kidney)) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN cell) (NN line) (CD 293)) (-RRB- -RRB-))) (NP (NP (NN over-expressing) (NN _PROT1_)) (CC or) (NP (NN HeLa) (NNS cells)))) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NN _PROT_))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB rapidly)) (VP (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBD was) (VP (VBN phosphorylated))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (NP (NP (JJ human) (JJ embryonic) (NN kidney)) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN cell) (NN line) (CD 293)) (-RRB- -RRB-))) (NP (NP (NN over-expressing) (NN _PROT_)) (CC or) (NP (NN HeLa) (NNS cells)))) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (NP (NN _PROT2_)) (ADVP (RB rapidly)) (VP (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex)))) (CC and) (VP (VBD was) (VP (VBN phosphorylated))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (NP (NP (JJ human) (JJ embryonic) (NN kidney)) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN cell) (NN line) (CD 293)) (-RRB- -RRB-))) (NP (NP (NN over-expressing) (NN _PROT_)) (CC or) (NP (NN HeLa) (NNS cells)))) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB rapidly)) (VP (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBD was) (VP (VBN phosphorylated))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (WHADVP (WRB When)) (S (NP (NP (NP (NP (JJ human) (JJ embryonic) (NN kidney)) (NNS cells)) (PRN (-LRB- -LRB-) (NP (NN cell) (NN line) (CD 293)) (-RRB- -RRB-))) (NP (NP (NN over-expressing) (NN _PROT_)) (CC or) (NP (NN HeLa) (NNS cells)))) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NN _PROT_))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB rapidly)) (VP (VP (VBN associated) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBD was) (VP (VBN phosphorylated))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ primary) (NN amino) (NN acid) (NN sequence)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ shares) (NP (NP (NN similarity)) (PP (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN pelle)) (, ,) (NP (NP (DT a) (NN protein) (NN kinase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (DT a) (NP (NN _PROT2_) (NN _PROT2_)) (NN homolog)) (PP (IN in) (NP (NN Drosophila))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT2_) (NN _PROT2_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT1_) (NN _PROT1_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT1_) (NN _PROT1_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT1_) (NN _PROT1_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT1_) (NN _PROT1_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT1_) (NN _PROT1_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT1_) (NN _PROT1_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN phagocyte) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (NP (DT a) (NN complex)) (PP (IN of) (NP (NN membrane) (NN _PROT_) (NN _PROT_))) (-LRB- -LRB-) (VP (VBN comprised) (PP (IN of) (NP (NNS subunits) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))) (-RRB- -RRB-)) (CC and) (NP (NP (NP (CD three) (NN cytosol) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP translocate) (PP (TO to) (NP (NN membrane)))) (CC and) (VP (VBP bind) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ is) (NP (NP (DT the) (JJ first) (NN report)) (S (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP (NP (NP (CD two)) (PP (IN of) (NP (NP (JJ cytosolic) (NNS components)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))))) (, ,) (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (NN _PROT_))))) (NP (DT each) (JJ other)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ is) (NP (NP (DT the) (JJ first) (NN report)) (S (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP (NP (NP (CD two)) (PP (IN of) (NP (NP (JJ cytosolic) (NNS components)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))))) (, ,) (NP (NP (NN _PROT_) (NN binding)) (PP (TO to) (NP (NN _PROT2_))))) (NP (DT each) (JJ other)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ is) (NP (NP (DT the) (JJ first) (NN report)) (S (VP (TO to) (VP (VB demonstrate) (SBAR (IN that) (S (NP (NP (NP (CD two)) (PP (IN of) (NP (NP (JJ cytosolic) (NNS components)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))))) (, ,) (NP (NP (NN _PROT1_) (NN binding)) (PP (TO to) (NP (NN _PROT2_))))) (NP (DT each) (JJ other)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (UCP (ADVP (FW In) (FW vitro)) (CC and) (PP (IN in) (NP (JJ nonproliferating) (NNS cells))) (, ,)) (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with))) (CC and) (VP (VBZ inhibits) (NP (NP (NP (NP (JJ cyclin/cycin-dependent) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NNS holoenzymes)) (VP (VBG containing) (NP (CC either) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (UCP (ADVP (FW In) (FW vitro)) (CC and) (PP (IN in) (NP (JJ nonproliferating) (NNS cells))) (, ,)) (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with))) (CC and) (VP (VBZ inhibits) (NP (NP (NP (NP (JJ cyclin/cycin-dependent) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NNS holoenzymes)) (VP (VBG containing) (NP (CC either) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC or) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (UCP (ADVP (FW In) (FW vitro)) (CC and) (PP (IN in) (NP (JJ nonproliferating) (NNS cells))) (, ,)) (NN _PROT1_)) (VP (VP (VBZ associates) (PP (IN with))) (CC and) (VP (VBZ inhibits) (NP (NP (NP (NP (JJ cyclin/cycin-dependent) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NNS holoenzymes)) (VP (VBG containing) (NP (CC either) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (UCP (ADVP (FW In) (FW vitro)) (CC and) (PP (IN in) (NP (JJ nonproliferating) (NNS cells))) (, ,)) (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with))) (CC and) (VP (VBZ inhibits) (NP (NP (NP (NP (JJ cyclin/cycin-dependent) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NNS holoenzymes)) (VP (VBG containing) (NP (CC either) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC or) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (UCP (ADVP (FW In) (FW vitro)) (CC and) (PP (IN in) (NP (JJ nonproliferating) (NNS cells))) (, ,)) (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with))) (CC and) (VP (VBZ inhibits) (NP (NP (NP (NP (JJ cyclin/cycin-dependent) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NNS holoenzymes)) (VP (VBG containing) (NP (CC either) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (UCP (ADVP (FW In) (FW vitro)) (CC and) (PP (IN in) (NP (JJ nonproliferating) (NNS cells))) (, ,)) (NN _PROT_)) (VP (VP (VBZ associates) (PP (IN with))) (CC and) (VP (VBZ inhibits) (NP (NP (NP (NP (JJ cyclin/cycin-dependent) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NNS holoenzymes)) (VP (VBG containing) (NP (CC either) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC or) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ many) (JJ different) (NNS types)) (PP (IN of) (NP (VBG proliferating) (NNS cells)))) (VP (VBP contain) (NP (NN _PROT1_) (NN protein))))) (, ,) (NP (CC neither) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN with) (NP (CD cyclin/CDK) (NNS complexes)))))) (CC nor) (NP (NP (DT the) (NNS consequences)) (PP (IN of) (NP (NP (DT this) (NN interaction)) (PP (IN during) (NP (DT the) (JJ mitotic) (NN cycle))))))) (VP (VBP have) (VP (VBN been) (ADVP (RB fully)) (VP (VBN explored))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (CD three) (JJ different) (NNS CDKs)) (: :) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (CD three) (JJ different) (NNS CDKs)) (: :) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (CD three) (JJ different) (NNS CDKs)) (: :) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (CD three) (JJ different) (NNS CDKs)) (: :) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (CD three) (JJ different) (NNS CDKs)) (: :) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (CD three) (JJ different) (NNS CDKs)) (: :) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (ADJP (RB significantly) (JJR lower)) (PP (IN than) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (DT these) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT2_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT2_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT1_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT2_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT1_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_))))) (VP (VBZ does) (RB not) (VP (VB change) (PP (IN in) (NP (DT a) (ADJP (NN cell) (JJ cycle-dependent)) (NN fashion)))))) (: ;) (S (PP (IN in) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_))))) (VP (VP (VBZ is) (ADJP (JJS lowest) (PP (IN in) (NP (JJ early) (NN G1) (NNS cells))))) (CC and) (VP (VBZ increases) (PP (TO to) (NP (NP (DT a) (NN maximum)) (PP (IN in) (NP (NN mid-G1) (NN phase))))) (, ,) (S (VP (VBG reaching) (NP (NP (DT a) (JJ steady-state) (NN level)) (PP (IN in) (NP (JJ late) (NN G1-phase) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ substrate) (NN specificity)) (, ,) (NP (NP (DT the) (NN expression) (NN pattern)) (PP (IN of) (NP (DT this) (NN kinase)))) (, ,) (CC and) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB deplete) (NP (NP (CD 50) (NN %)) (PP (IN of) (NP (DT this) (NN kinase) (NN activity))) (PP (IN with) (NP (DT a) (JJ _PROT1_) (NN antibody))))))))) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN _PROT2_) (NN protein)) (VP (VBZ mediates) (, ,) (PP (IN in) (NP (NN part))) (, ,) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ substrate) (NN specificity)) (, ,) (NP (NP (DT the) (NN expression) (NN pattern)) (PP (IN of) (NP (DT this) (NN kinase)))) (, ,) (CC and) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB deplete) (NP (NP (CD 50) (NN %)) (PP (IN of) (NP (DT this) (NN kinase) (NN activity))) (PP (IN with) (NP (DT a) (JJ _PROT1_) (NN antibody))))))))) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VBZ mediates) (, ,) (PP (IN in) (NP (NN part))) (, ,) (NP (DT the) (JJ _PROT2_) (NN _PROT_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ substrate) (NN specificity)) (, ,) (NP (NP (DT the) (NN expression) (NN pattern)) (PP (IN of) (NP (DT this) (NN kinase)))) (, ,) (CC and) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB deplete) (NP (NP (CD 50) (NN %)) (PP (IN of) (NP (DT this) (NN kinase) (NN activity))) (PP (IN with) (NP (DT a) (JJ _PROT1_) (NN antibody))))))))) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VBZ mediates) (, ,) (PP (IN in) (NP (NN part))) (, ,) (NP (DT the) (JJ _PROT_) (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ substrate) (NN specificity)) (, ,) (NP (NP (DT the) (NN expression) (NN pattern)) (PP (IN of) (NP (DT this) (NN kinase)))) (, ,) (CC and) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB deplete) (NP (NP (CD 50) (NN %)) (PP (IN of) (NP (DT this) (NN kinase) (NN activity))) (PP (IN with) (NP (DT a) (JJ _PROT_) (NN antibody))))))))) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VBZ mediates) (, ,) (PP (IN in) (NP (NN part))) (, ,) (NP (DT the) (JJ _PROT2_) (NN _PROT_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ substrate) (NN specificity)) (, ,) (NP (NP (DT the) (NN expression) (NN pattern)) (PP (IN of) (NP (DT this) (NN kinase)))) (, ,) (CC and) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB deplete) (NP (NP (CD 50) (NN %)) (PP (IN of) (NP (DT this) (NN kinase) (NN activity))) (PP (IN with) (NP (DT a) (JJ _PROT_) (NN antibody))))))))) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VBZ mediates) (, ,) (PP (IN in) (NP (NN part))) (, ,) (NP (DT the) (JJ _PROT_) (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ substrate) (NN specificity)) (, ,) (NP (NP (DT the) (NN expression) (NN pattern)) (PP (IN of) (NP (DT this) (NN kinase)))) (, ,) (CC and) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB deplete) (NP (NP (CD 50) (NN %)) (PP (IN of) (NP (DT this) (NN kinase) (NN activity))) (PP (IN with) (NP (DT a) (JJ _PROT_) (NN antibody))))))))) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VBZ mediates) (, ,) (PP (IN in) (NP (NN part))) (, ,) (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN activity))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NN _PROT2_)))) (VP (VBP are) (ADJP (JJ incapable) (PP (IN of) (S (VP (VBG phosphorylating) (NP (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN _PROT1_) (NNS complexes)) (VP (VBG containing) (NP (NN _PROT_)))) (VP (VBP are) (ADJP (JJ incapable) (PP (IN of) (S (VP (VBG phosphorylating) (NP (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN _PROT_) (NNS complexes)) (VP (VBG containing) (NP (NN _PROT1_)))) (VP (VBP are) (ADJP (JJ incapable) (PP (IN of) (S (VP (VBG phosphorylating) (NP (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (DT a) (JJ model) (NN wherein) (S (NP (NN _PROT1_) (NN _PROT1_) (NNS complexes)) (VP (VB sequester) (NP (NP (DT the) (JJ _PROT2_) (NN kinase) (JJ inhibitory) (NN activity)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (DT a) (JJ model) (NN wherein) (S (NP (NN _PROT1_) (NN _PROT1_) (NNS complexes)) (VP (VB sequester) (NP (NP (DT the) (JJ _PROT_) (NN kinase) (JJ inhibitory) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (DT a) (JJ model) (NN wherein) (S (NP (NN _PROT_) (NN _PROT_) (NNS complexes)) (VP (VB sequester) (NP (NP (DT the) (JJ _PROT1_) (NN kinase) (JJ inhibitory) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN tumor) (NN suppressor)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN ankyrin) (CC and) (NN SH3) (NNS domains)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN core) (NN domain)) (VP (VBZ contains) (NP (NP (DT the) (JJ sequence-specific) (NN DNA) (NN binding) (NN activity)) (CC and) (NP (NP (DT the) (ADJP (FW in) (FW vitro)) (NN _PROT1_) (NN protein) (NN binding) (NN activity)) (PP (IN of) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN core) (NN domain)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN protein)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ contains) (NP (NP (DT an) (NN SH3) (PRN (-LRB- -LRB-) (NP (NN Src) (NN homology) (CD 3)) (-RRB- -RRB-)) (NN domain)) (CC and) (NP (NP (CD four) (NN ankyrin) (NNS repeats)) (, ,) (VP (VBD revealed) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT the) (NN SH3) (NN domain)) (VP (VBZ binds) (NP (NP (DT the) (NN L3) (NN loop)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (NN SH3-polyproline) (NN peptide) (NNS complexes))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NP (NP (DT an) (NN ankyrin) (NN repeat)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ forms) (NP (NP (DT an) (JJ L-shaped) (NN structure)) (VP (VBG consisting) (PP (IN of) (NP (NP (DT a) (NN beta) (NN hairpin)) (CC and) (NP (CD two) (NN alpha) (NNS helices))))))))) (, ,)) (VP (VBZ binds) (NP (NP (DT the) (NN L2) (NN loop)) (PP (IN of) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN core) (NN domain)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN protein)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ contains) (NP (NP (DT an) (NN SH3) (PRN (-LRB- -LRB-) (NP (NN Src) (NN homology) (CD 3)) (-RRB- -RRB-)) (NN domain)) (CC and) (NP (NP (CD four) (NN ankyrin) (NNS repeats)) (, ,) (VP (VBD revealed) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT the) (NN SH3) (NN domain)) (VP (VBZ binds) (NP (NP (DT the) (NN L3) (NN loop)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (NN SH3-polyproline) (NN peptide) (NNS complexes))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NP (NP (DT an) (NN ankyrin) (NN repeat)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ forms) (NP (NP (DT an) (JJ L-shaped) (NN structure)) (VP (VBG consisting) (PP (IN of) (NP (NP (DT a) (NN beta) (NN hairpin)) (CC and) (NP (CD two) (NN alpha) (NNS helices))))))))) (, ,)) (VP (VBZ binds) (NP (NP (DT the) (NN L2) (NN loop)) (PP (IN of) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN core) (NN domain)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN protein)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ contains) (NP (NP (DT an) (NN SH3) (PRN (-LRB- -LRB-) (NP (NN Src) (NN homology) (CD 3)) (-RRB- -RRB-)) (NN domain)) (CC and) (NP (NP (CD four) (NN ankyrin) (NNS repeats)) (, ,) (VP (VBD revealed) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT the) (NN SH3) (NN domain)) (VP (VBZ binds) (NP (NP (DT the) (NN L3) (NN loop)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (NN SH3-polyproline) (NN peptide) (NNS complexes))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NP (NP (DT an) (NN ankyrin) (NN repeat)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ forms) (NP (NP (DT an) (JJ L-shaped) (NN structure)) (VP (VBG consisting) (PP (IN of) (NP (NP (DT a) (NN beta) (NN hairpin)) (CC and) (NP (CD two) (NN alpha) (NNS helices))))))))) (, ,)) (VP (VBZ binds) (NP (NP (DT the) (NN L2) (NN loop)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN core) (NN domain)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN _PROT1_) (NN protein)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ contains) (NP (NP (DT an) (NN SH3) (PRN (-LRB- -LRB-) (NP (NN Src) (NN homology) (CD 3)) (-RRB- -RRB-)) (NN domain)) (CC and) (NP (NP (CD four) (NN ankyrin) (NNS repeats)) (, ,) (VP (VBD revealed) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT the) (NN SH3) (NN domain)) (VP (VBZ binds) (NP (NP (DT the) (NN L3) (NN loop)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (NN SH3-polyproline) (NN peptide) (NNS complexes))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NP (NP (DT an) (NN ankyrin) (NN repeat)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ forms) (NP (NP (DT an) (JJ L-shaped) (NN structure)) (VP (VBG consisting) (PP (IN of) (NP (NP (DT a) (NN beta) (NN hairpin)) (CC and) (NP (CD two) (NN alpha) (NNS helices))))))))) (, ,)) (VP (VBZ binds) (NP (NP (DT the) (NN L2) (NN loop)) (PP (IN of) (NP (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN core) (NN domain)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN _PROT1_) (NN protein)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ contains) (NP (NP (DT an) (NN SH3) (PRN (-LRB- -LRB-) (NP (NN Src) (NN homology) (CD 3)) (-RRB- -RRB-)) (NN domain)) (CC and) (NP (NP (CD four) (NN ankyrin) (NNS repeats)) (, ,) (VP (VBD revealed) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT the) (NN SH3) (NN domain)) (VP (VBZ binds) (NP (NP (DT the) (NN L3) (NN loop)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (NN SH3-polyproline) (NN peptide) (NNS complexes))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NP (NP (DT an) (NN ankyrin) (NN repeat)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ forms) (NP (NP (DT an) (JJ L-shaped) (NN structure)) (VP (VBG consisting) (PP (IN of) (NP (NP (DT a) (NN beta) (NN hairpin)) (CC and) (NP (CD two) (NN alpha) (NNS helices))))))))) (, ,)) (VP (VBZ binds) (NP (NP (DT the) (NN L2) (NN loop)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN core) (NN domain)))) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN protein)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ contains) (NP (NP (DT an) (NN SH3) (PRN (-LRB- -LRB-) (NP (NN Src) (NN homology) (CD 3)) (-RRB- -RRB-)) (NN domain)) (CC and) (NP (NP (CD four) (NN ankyrin) (NNS repeats)) (, ,) (VP (VBD revealed) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT the) (NN SH3) (NN domain)) (VP (VBZ binds) (NP (NP (DT the) (NN L3) (NN loop)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (PP (IN of) (NP (ADJP (RB previously) (VBN characterized)) (NN SH3-polyproline) (NN peptide) (NNS complexes))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NP (NP (DT an) (NN ankyrin) (NN repeat)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ forms) (NP (NP (DT an) (JJ L-shaped) (NN structure)) (VP (VBG consisting) (PP (IN of) (NP (NP (DT a) (NN beta) (NN hairpin)) (CC and) (NP (CD two) (NN alpha) (NNS helices))))))))) (, ,)) (VP (VBZ binds) (NP (NP (DT the) (NN L2) (NN loop)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN structure)) (PP (IN of) (NP (DT the) (NN complex)))) (VP (VBZ shows) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (NN binding) (NN site)) (PP (IN on) (NP (DT the) (NN _PROT2_) (NN core) (NN domain)))) (VP (VBZ consists) (PP (IN of) (NP (NP (ADJP (RB evolutionarily) (VBN conserved)) (NNS regions)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (ADVP (RB frequently)) (VP (VBN mutated) (PP (IN in) (NP (NN cancer)))))))))))) (CC and) (SBAR (IN that) (S (NP (PRP it)) (VP (VBZ overlaps) (NP (NP (DT the) (NN site)) (PP (IN of) (NP (NN DNA) (NN binding)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (CD six) (ADJP (ADVP (RBS most) (RB frequently)) (VBN observed)) (NN _PROT1_) (NNS mutations)) (VP (VBP disrupt) (NP (NN _PROT2_) (NN binding)) (ADVP (FW in) (FW vitro)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (VP (VBZ provides) (NP (NN evidence) (SBAR (IN that) (S (NP (DT the) (CD _PROT1_AND_PROT2_) (NN complex)) (VP (VP (VBZ forms) (ADVP (FW in) (FW vivo))) (CC and) (VP (MD may) (VP (VB have) (NP (DT a) (JJ critical) (NN role)) (PP (IN in) (NP (NP (DT the) (NN _PROT_) (NN pathway)) (PP (IN of) (NP (NN tumor) (NN suppression))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (VP (VBZ provides) (NP (NN evidence) (SBAR (IN that) (S (NP (DT the) (CD _PROT1_) (NN complex)) (VP (VP (VBZ forms) (ADVP (FW in) (FW vivo))) (CC and) (VP (MD may) (VP (VB have) (NP (DT a) (JJ critical) (NN role)) (PP (IN in) (NP (NP (DT the) (NN _PROT2_) (NN pathway)) (PP (IN of) (NP (NN tumor) (NN suppression))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (VP (VBZ provides) (NP (NN evidence) (SBAR (IN that) (S (NP (DT the) (CD _PROT1_) (NN complex)) (VP (VP (VBZ forms) (ADVP (FW in) (FW vivo))) (CC and) (VP (MD may) (VP (VB have) (NP (DT a) (JJ critical) (NN role)) (PP (IN in) (NP (NP (DT the) (NN _PROT2_) (NN pathway)) (PP (IN of) (NP (NN tumor) (NN suppression))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NN epitope-tagging)))) (, ,) (NP (NP (NN interaction)) (PP (IN of) (NP (NN _PROT1_) (JJ basic-helix-loop-helix) (NN protein))) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (NN protein)) (VP (VBN encoded) (PP (IN by) (NP (DT this) (JJ novel) (NN cDNA))))))) (VP (VBD was) (VP (VBN confirmed) (PP (IN by) (NP (NP (NN immunoprecipitation) (NNS experiments)) (PP (IN in) (NP (NN COS7) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Interactions)) (PP (IN with) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (NN mouse) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (VP (VBD were) (VP (VBN confirmed) (S (VP (VBG using) (NP (NN glutathione) (JJ transferase-tagged) (NNS cDNAs))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN cDNA)) (VP (VBG encoding) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN protein) (NN sequence)))))) (VP (VBD interacted) (PP (IN with) (NP (DT the) (NN _PROT2_) (JJ basic-helix-loop-helix))) (SBAR (WHADVP (RB only) (WRB when)) (S (VP (VBN fused) (PP (TO to) (NP (DT a) (NN beta-galactosidase) (NN tag)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ is) (RB not) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN vitamin) (NN A) (NN status)) (PP (IN during) (NP (NP (NN infection)) (PP (IN in) (NP (JJ hospitalised) (NNS children))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ is) (RB not) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN vitamin) (NN A) (NN status)) (PP (IN during) (NP (NP (NN infection)) (PP (IN in) (NP (JJ hospitalised) (NNS children))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ is) (RB not) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN vitamin) (NN A) (NN status)) (PP (IN during) (NP (NP (NN infection)) (PP (IN in) (NP (JJ hospitalised) (NNS children))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBZ is) (RB not) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN vitamin) (NN A) (NN status)) (PP (IN during) (NP (NP (NN infection)) (PP (IN in) (NP (JJ hospitalised) (NNS children))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ is) (RB not) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN vitamin) (NN A) (NN status)) (PP (IN during) (NP (NP (NN infection)) (PP (IN in) (NP (JJ hospitalised) (NNS children))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBZ is) (RB not) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN vitamin) (NN A) (NN status)) (PP (IN during) (NP (NP (NN infection)) (PP (IN in) (NP (JJ hospitalised) (NNS children))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN usefulness)) (PP (IN of) (NP (NP (DT the) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (S (VP (TO to) (VP (VB determine) (NP (NP (NP (NN vitamin) (NN A)) (PRN (-LRB- -LRB-) (NP (NN VA)) (-RRB- -RRB-))) (NN status)) (PP (IN during) (NP (NN infection)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN usefulness)) (PP (IN of) (NP (NP (DT the) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (S (VP (TO to) (VP (VB determine) (NP (NP (NP (NN vitamin) (NN A)) (PRN (-LRB- -LRB-) (NP (NN VA)) (-RRB- -RRB-))) (NN status)) (PP (IN during) (NP (NN infection)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN usefulness)) (PP (IN of) (NP (NP (DT the) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (S (VP (TO to) (VP (VB determine) (NP (NP (NP (NN vitamin) (NN A)) (PRN (-LRB- -LRB-) (NP (NN VA)) (-RRB- -RRB-))) (NN status)) (PP (IN during) (NP (NN infection)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN usefulness)) (PP (IN of) (NP (NP (DT the) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (S (VP (TO to) (VP (VB determine) (NP (NP (NP (NN vitamin) (NN A)) (PRN (-LRB- -LRB-) (NP (NN VA)) (-RRB- -RRB-))) (NN status)) (PP (IN during) (NP (NN infection)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN usefulness)) (PP (IN of) (NP (NP (DT the) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (S (VP (TO to) (VP (VB determine) (NP (NP (NP (NN vitamin) (NN A)) (PRN (-LRB- -LRB-) (NP (NN VA)) (-RRB- -RRB-))) (NN status)) (PP (IN during) (NP (NN infection)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN usefulness)) (PP (IN of) (NP (NP (DT the) (JJ molar) (NN ratio)) (PP (IN of) (NP (NP (NN serum) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (TO to) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (S (VP (TO to) (VP (VB determine) (NP (NP (NP (NN vitamin) (NN A)) (PRN (-LRB- -LRB-) (NP (NN VA)) (-RRB- -RRB-))) (NN status)) (PP (IN during) (NP (NN infection)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (S (NP (PRP We)) (VP (VBD took) (NP (NP (NN advantage)) (PP (IN of) (NP (ADJP (RB previously) (VBN collected)) (NNS data)))) (PP (IN during) (NP (DT a) (JJ randomised) (ADJP (ADJP (JJ double-blind)) (, ,) (ADJP (JJ placebo-controlled))) (JJ clinical) (NN trial))) (S (VP (TO to) (VP (VB conduct) (NP (NP (NP (DT a) (JJ secondary) (NN analysis)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN ratio)))) (CC and) (NP (NP (PRP$ its) (NN relationship)) (PP (TO to) (NP (NP (NN infection)) (CC and) (NP (NN VA) (NN status))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ MAIN) (NN OUTCOME) (NNS MEASURES)) (: :) (NP (NP (NN _PROT1_AND_PROT2_) (JJ molar) (NN ratio)) (PP (IN after) (NP (CD 7) (NNS days) (NN hospitalisation)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT1_) (: :) (NN _PROT2_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT1_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT2_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT1_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT2_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT1_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT2_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT1_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT2_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT1_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT2_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT1_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT2_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT1_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT2_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT1_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT2_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT1_)))))) (: :) (S (NP (NP (NN _PROT2_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT1_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT2_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT1_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT2_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT1_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT2_) (: :) (NN _PROT_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT1_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT2_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNS RESULTS) (: :) (S (S (PP (IN After) (NP (NP (NP (CD 7) (NNS days)) (NP (NN hospitalisation))) (, ,) (NP (NP (NP (JJ molar) (NN _PROT_) (: :) (NN _PROT_) (NN ratio)) (PRN (-LRB- -LRB-) (NP (NN mean+/-s.d.)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (NP (JJ infected) (NNS children)) (PRN (-LRB- -LRB-) (NP (JJ C-reactive) (NN proteins>10) (NN mg/l)) (-RRB- -RRB-))) (VP (VBD was) (NP (CD 0.67+/-0.31)) (PP (IN in) (NP (NP (DT the) (JJ high-dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (CD 0.74+/-0.44)) (PP (IN in) (NP (NP (NP (NP (DT the) (JJ low) (NN dose) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=71)) (-RRB- -RRB-))) (CC and) (NP (CD 0.73+/-0.39))) (PP (IN in) (NP (NP (DT the) (NN placebo) (NN group)) (PRN (-LRB- -LRB-) (NP (CD n=81)) (-RRB- -RRB-))))))) (. .))) (NP (DT These) (NNS values)) (VP (VBD did) (RB not) (VP (VB differ) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (JJ one-way) (NN ANOVA) (NN P=0.472)) (-RRB- -RRB-)))) (. .)) (FW In))) (NP (NP (NNS patients)) (PP (IN with) (NP (NP (NN baseline) (NN serum) (NN retinol) (CD concentrations<0.70) (NN micromol/l)) (, ,) (NP (NP (NNS changes)) (PP (IN in) (NP (NN _PROT_)))))) (: :) (S (NP (NP (NN _PROT_) (NN ratio)) (PP (IN between) (NP (NP (NN admission)) (CC and) (NP (NN day) (CD 7))))) (VP (VBD were) (RB not) (ADJP (RB statistically) (JJ different) (PP (IN in) (NP (NP (DT the) (CD three) (NNS groups)) (PRN (-LRB- -LRB-) (NP (NN one-way) (NN ANOVA) (NN P=0.548)) (-RRB- -RRB-))))))) (. .))) (NNS CONCLUSIONS)) (: :) (S (PP (IN In) (NP (NP (DT this) (NN population)) (PP (IN of) (NP (JJ malnourished) (JJ hospitalised) (NNS children))))) (, ,) (NP (JJ molar) (NN _PROT1_) (: :) (NN _PROT2_) (NN ratio)) (VP (VBZ does) (RB not) (VP (VBP appear) (VP (TO to) (VP (VB be) (ADJP (JJ useful) (S (VP (TO to) (VP (VB assess) (NP (NN VA) (NN status)) (PP (IN during) (NP (NP (NN infection.) (NN SPONSORSHIP)) (: :) (S (NP (PRP$ Our) (NN research)) (VP (VBD was) (ADVP (RB partially)) (VP (VBN supported) (PP (IN by) (NP (NP (DT a) (NN grant)) (PP (IN from) (NP (NP (NP (DT the) (NNP Fonds) (FW de) (NN la)) (NP (NNP Recherche) (NNP Scientifique) (FW et) (FW Medicale)) (PRN (-LRB- -LRB-) (NP (NN contract) (CD 3.4505.94)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NP (NNP David)) (CC and) (NP (NNP Alice) (NNP Van) (NNP Buuren) (NNP Foundation))))))))))))))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Concentrations)) (PP (IN of) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (JJ cerebrospinal) (NN fluid)) (PRN (-LRB- -LRB-) (NP (NN CSF)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN measured) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (ADJP (JJ second-stage) (ADVP (FW Trypanosoma) (FW brucei))) (NN gambiense) (NN sleeping) (NN sickness)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Concentrations)) (PP (IN of) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT2_) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (JJ cerebrospinal) (NN fluid)) (PRN (-LRB- -LRB-) (NP (NN CSF)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN measured) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (ADJP (JJ second-stage) (ADVP (FW Trypanosoma) (FW brucei))) (NN gambiense) (NN sleeping) (NN sickness)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Concentrations)) (PP (IN of) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (JJ cerebrospinal) (NN fluid)) (PRN (-LRB- -LRB-) (NP (NN CSF)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN measured) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (ADJP (JJ second-stage) (ADVP (FW Trypanosoma) (FW brucei))) (NN gambiense) (NN sleeping) (NN sickness)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Concentrations)) (PP (IN of) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT2_) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (JJ cerebrospinal) (NN fluid)) (PRN (-LRB- -LRB-) (NP (NN CSF)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN measured) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (ADJP (JJ second-stage) (ADVP (FW Trypanosoma) (FW brucei))) (NN gambiense) (NN sleeping) (NN sickness)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Concentrations)) (PP (IN of) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (JJ cerebrospinal) (NN fluid)) (PRN (-LRB- -LRB-) (NP (NN CSF)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN measured) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (ADJP (JJ second-stage) (ADVP (FW Trypanosoma) (FW brucei))) (NN gambiense) (NN sleeping) (NN sickness)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Concentrations)) (PP (IN of) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (JJ cerebrospinal) (NN fluid)) (PRN (-LRB- -LRB-) (NP (NN CSF)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN measured) (PP (IN in) (NP (NP (NNS patients)) (PP (IN with) (NP (ADJP (JJ second-stage) (ADVP (FW Trypanosoma) (FW brucei))) (NN gambiense) (NN sleeping) (NN sickness)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NNS Correlations)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NNS _PROT2_)) (PP (IN in) (NP (NN CSF))) (PP (IN as) (NP (NP (NNS markers)) (PP (IN for) (NP (NP (NN astrogliosis)) (CC and) (NP (NN neurodegeneration)))))))))) (, ,) (CC and) (NP (ADJP (ADJP (JJ clinical)) (CC and) (ADJP (JJ biological))) (NNS data))) (VP (VBD were) (VP (VBN investigated)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Abnormal) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (ADVP (RB significantly)) (VP (VBN associated) (PP (PP (IN with) (S (VP (VBG increasing) (NP (NP (NN CSF) (NN cell) (NN number)) (CC and) (NP (NN protein) (NN concentration)))))) (, ,) (CC and) (PP (IN with) (NP (NP (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN lymph) (NNS nodes)))) (CC or) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NNS trypanosomes))))) (PP (IN in) (NP (NP (NN lymph) (NN node)) (NN aspirate))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Accordingly)) (, ,) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN population) (NNS studies)))) (VP (VBP have) (VP (VBN explored) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (JJ ischaemic) (NN heart) (NN disease))) (PP (IN with) (NP (NP (NN gene) (NNS polymorphisms)) (PP (IN of) (NP (NP (DT the) (JJ inflammatory) (NNS molecules) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (NN beta))) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_)) (CC and) (NP (CD 2))) (, ,) (NP (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NP (PRP$ its) (NN receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (NN receptor)) (PP (IN for) (NP (NN lipopolysaccharide)))) (-RRB- -RRB-))) (, ,) (NP (NN P) (CC and) (NN E) (NNS selectins)) (, ,) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Present) (NNS data)) (VP (VBG concerning) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN system)) (PP (IN of) (NP (JJ extrarenal) (NN origin)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT2_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT2_)) (NP (NN _PROT2_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT1_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT1_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT1_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT2_)) (NP (NN _PROT2_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT1_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT2_)) (NP (NN _PROT2_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT2_)) (NP (NN _PROT2_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN After) (NP (NP (DT a) (JJ brief) (JJ historical) (NN incursion)) (PP (VBG regarding) (NP (NP (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin))))))) (, ,) (NP (PRP we)) (VP (VBP present) (NP (DT the) (JJ main) (JJ extrarenal) (JJ _PROT_) (NNS enzymes)) (, ,) (S (VP (VP (VBG starting) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN D)) (CC and) (NP (NN _PROT1_)) (NP (NN _PROT1_))))) (CC and) (VP (VBG ending) (PP (IN with) (NP (DT the) (NP (NN conversion) (NN enzyme)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (NN end))) (NP (PRP we)) (VP (VBP refer) (PP (TO to) (NP (NP (DT the) (NNS relations)) (PP (IN between) (NP (NP (NP (JJ circulating) (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin)))) (CC and) (NP (NP (DT the) (JJ extrarenal) (NN _PROT2_)) (ADJP (JJ specific) (PP (TO to) (NP (NP (NN tissue)) (VP (VBG underlying) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (CD two) (NN _PROT_) (NNS components)) (VP (VP (VBP cooperate)) (CC and) (VP (VB constitute) (NP (NP (DT a) (JJ unitary) (JJ hormonal) (NN system)) (, ,) (VP (VP (VBG regulating) (NP (NP (DT the) (JJ major) (NNS functions)) (PP (IN of) (NP (DT the) (NN organism))))) (CC and) (VP (VBG maintaining) (NP (DT the) (JJ main) (JJ homeostatic) (NN equilibria)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (NN end))) (NP (PRP we)) (VP (VBP refer) (PP (TO to) (NP (NP (DT the) (NNS relations)) (PP (IN between) (NP (NP (NP (JJ circulating) (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin)))) (CC and) (NP (NP (DT the) (JJ extrarenal) (NN _PROT_)) (ADJP (JJ specific) (PP (TO to) (NP (NP (NN tissue)) (VP (VBG underlying) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (CD two) (NN _PROT2_) (NNS components)) (VP (VP (VBP cooperate)) (CC and) (VP (VB constitute) (NP (NP (DT a) (JJ unitary) (JJ hormonal) (NN system)) (, ,) (VP (VP (VBG regulating) (NP (NP (DT the) (JJ major) (NNS functions)) (PP (IN of) (NP (DT the) (NN organism))))) (CC and) (VP (VBG maintaining) (NP (DT the) (JJ main) (JJ homeostatic) (NN equilibria)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (NN end))) (NP (PRP we)) (VP (VBP refer) (PP (TO to) (NP (NP (DT the) (NNS relations)) (PP (IN between) (NP (NP (NP (JJ circulating) (NN _PROT_)) (PP (IN of) (NP (JJ renal) (NN origin)))) (CC and) (NP (NP (DT the) (JJ extrarenal) (NN _PROT1_)) (ADJP (JJ specific) (PP (TO to) (NP (NP (NN tissue)) (VP (VBG underlying) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (CD two) (NN _PROT2_) (NNS components)) (VP (VP (VBP cooperate)) (CC and) (VP (VB constitute) (NP (NP (DT a) (JJ unitary) (JJ hormonal) (NN system)) (, ,) (VP (VP (VBG regulating) (NP (NP (DT the) (JJ major) (NNS functions)) (PP (IN of) (NP (DT the) (NN organism))))) (CC and) (VP (VBG maintaining) (NP (DT the) (JJ main) (JJ homeostatic) (NN equilibria)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NP (DT the) (JJ circulating) (NN _PROT1_)) (PP (IN of) (NP (JJ renal) (NN origin)))) (VP (VBZ is) (ADVP (RB acutely)) (VP (VBN activated) (S (VP (TO to) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN accomplishment)) (PP (IN of) (NP (JJ short) (NN term) (JJ homeostatic) (NNS reactions)))))))))))) (, ,) (NP (NN tissue) (NN _PROT2_)) (, ,) (PP (IN in) (NP (ADJP (ADJP (JJ paracrine)) (CC or) (ADJP (JJ autocrine))) (NNS ways))) (, ,) (VP (VBZ exerts) (NP (NP (JJ local-regional) (JJ adaptive) (NNS actions)) (PP (IN of) (NP (JJ long) (NN duration))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN by) (NP (NP (NP (NN NK) (NNS cells)) (PP (IN in) (NP (NN cancer) (NNS patients)))) (CC and) (NP (NP (NN correlation)) (PP (IN of) (NP (NP (JJ impaired) (NN _PROT_) (NN expression) (NN withprogression)) (PP (IN of) (NP (NN cancer)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN by) (NP (NP (NP (NN NK) (NNS cells)) (PP (IN in) (NP (NN cancer) (NNS patients)))) (CC and) (NP (NP (NN correlation)) (PP (IN of) (NP (NP (JJ impaired) (NN _PROT2_) (NN expression) (NN withprogression)) (PP (IN of) (NP (NN cancer)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Differential) (NN expression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN by) (NP (NP (NP (NN NK) (NNS cells)) (PP (IN in) (NP (NN cancer) (NNS patients)))) (CC and) (NP (NP (NN correlation)) (PP (IN of) (NP (NP (JJ impaired) (NN _PROT2_) (NN expression) (NN withprogression)) (PP (IN of) (NP (NN cancer)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN identified) (PP (IN as) (NP (NP (DT an) (NN effector) (NN molecule)) (VP (VBN co-localized) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (JJ cytotoxic) (NNS granules)) (PP (IN of) (NP (NP (JJ cytotoxic) (NN T) (NNS lymphocytes)) (CC and) (NP (NP (NP (JJ natural) (NN killer)) (PRN (-LRB- -LRB-) (NP (NN NK)) (-RRB- -RRB-))) (NNS cells)))))))))))) (, ,) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN reported) (S (VP (VP (TO to) (VP (VB kill) (NP (NP (JJ intracellular) (NNS pathogens)) (PP (IN in) (NP (JJ infected) (NNS cells)))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (DT a) (JJ cytotoxic) (NN effect)) (PP (IN against) (NP (NN tumor) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN identified) (PP (IN as) (NP (NP (DT an) (NN effector) (NN molecule)) (VP (VBN co-localized) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (JJ cytotoxic) (NNS granules)) (PP (IN of) (NP (NP (JJ cytotoxic) (NN T) (NNS lymphocytes)) (CC and) (NP (NP (NP (JJ natural) (NN killer)) (PRN (-LRB- -LRB-) (NP (NN NK)) (-RRB- -RRB-))) (NNS cells)))))))))))) (, ,) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN reported) (S (VP (VP (TO to) (VP (VB kill) (NP (NP (JJ intracellular) (NNS pathogens)) (PP (IN in) (NP (JJ infected) (NNS cells)))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (DT a) (JJ cytotoxic) (NN effect)) (PP (IN against) (NP (NN tumor) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN identified) (PP (IN as) (NP (NP (DT an) (NN effector) (NN molecule)) (VP (VBN co-localized) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (JJ cytotoxic) (NNS granules)) (PP (IN of) (NP (NP (JJ cytotoxic) (NN T) (NNS lymphocytes)) (CC and) (NP (NP (NP (JJ natural) (NN killer)) (PRN (-LRB- -LRB-) (NP (NN NK)) (-RRB- -RRB-))) (NNS cells)))))))))))) (, ,) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN reported) (S (VP (VP (TO to) (VP (VB kill) (NP (NP (JJ intracellular) (NNS pathogens)) (PP (IN in) (NP (JJ infected) (NNS cells)))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (DT a) (JJ cytotoxic) (NN effect)) (PP (IN against) (NP (NN tumor) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ present) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB elucidate) (SBAR (IN whether) (S (NP (NP (JJ intracellular) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN by) (NP (NN NK) (NNS cells)))) (VP (MD might) (VP (VB be) (VP (VBN associated) (PP (IN with) (NP (NP (NN progression)) (PP (IN of) (NP (NN cancer))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Flow) (JJ cytometric) (NN analysis)) (VP (VBD demonstrated) (NP (NP (JJ high) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN expression))))) (PP (IN by) (NP (NP (NP (NP (NP (NP (NN _PROT_)) (-LRB- -LRB-) (CC -) (-RRB- -RRB-)) (NN _PROT_)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS cells)) (PP (IN in) (NP (JJ healthy) (NNS controls))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Flow) (JJ cytometric) (NN analysis)) (VP (VBD demonstrated) (NP (NP (JJ high) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN expression))))) (PP (IN by) (NP (NP (NP (NP (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (CC -) (-RRB- -RRB-)) (NN _PROT_)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS cells)) (PP (IN in) (NP (JJ healthy) (NNS controls))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Flow) (JJ cytometric) (NN analysis)) (VP (VBD demonstrated) (NP (NP (JJ high) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN expression))))) (PP (IN by) (NP (NP (NP (NP (NP (NP (NN _PROT_)) (-LRB- -LRB-) (CC -) (-RRB- -RRB-)) (NN _PROT2_)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS cells)) (PP (IN in) (NP (JJ healthy) (NNS controls))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Flow) (JJ cytometric) (NN analysis)) (VP (VBD demonstrated) (NP (NP (JJ high) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN expression))))) (PP (IN by) (NP (NP (NP (NP (NP (NP (NN _PROT2_)) (-LRB- -LRB-) (CC -) (-RRB- -RRB-)) (NN _PROT_)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS cells)) (PP (IN in) (NP (JJ healthy) (NNS controls))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Flow) (JJ cytometric) (NN analysis)) (VP (VBD demonstrated) (NP (NP (JJ high) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN expression))))) (PP (IN by) (NP (NP (NP (NP (NP (NP (NN _PROT_)) (-LRB- -LRB-) (CC -) (-RRB- -RRB-)) (NN _PROT2_)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS cells)) (PP (IN in) (NP (JJ healthy) (NNS controls))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Flow) (JJ cytometric) (NN analysis)) (VP (VBD demonstrated) (NP (NP (JJ high) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN expression))))) (PP (IN by) (NP (NP (NP (NP (NP (NP (NN _PROT1_)) (-LRB- -LRB-) (CC -) (-RRB- -RRB-)) (NN _PROT2_)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS cells)) (PP (IN in) (NP (JJ healthy) (NNS controls))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NN cancer) (NNS patients)) (VP (VBD exhibited) (NP (NP (ADJP (RB significantly) (VBN decreased)) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_) (NN expression)) (PRN (-LRB- -LRB-) (NP (NN P<0.005)) (-RRB- -RRB-))))) (, ,) (PP (IN despite) (S (VP (VBG having) (NP (NP (ADJP (RB equally) (JJ high)) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_) (NN expression)) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (JJ healthy) (NNS controls))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ tumor-free) (NNS patients)) (VP (VBD expressed) (NP (NN _PROT1_)) (PP (IN at) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (JJ healthy) (NNS controls)))))) (, ,) (SBAR (IN while) (S (NP (DT the) (JJ progressive) (JJ tumor-bearing) (NNS patients)) (VP (VBD expressed) (NP (NP (ADJP (RB remarkably) (JJR lower)) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (PP (VBN compared) (PP (TO to) (NP (NP (JJ healthy) (NNS controls)) (PRN (-LRB- -LRB-) (NP (NN P<0.0001)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (S (NP (NP (JJ impaired) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN NK) (NNS cells)))) (VP (VBZ correlates) (PP (IN with) (NP (NP (NN progression)) (PP (IN of) (NP (NN cancer))))))) (, ,) (CC and) (S (NP (NP (NN determination)) (PP (IN of) (NP (NN _PROT2_) (NN expression)))) (VP (MD might) (VP (VB prove) (ADJP (JJ informative) (PP (IN for) (S (VP (VBG assessing) (NP (NP (DT the) (JJ immunological) (NN condition)) (PP (IN of) (NP (NN cancer) (NNS patients)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN probed) (NP (NP (NP (DT an) (NN epitope) (NN sequence)) (PRN (-LRB- -LRB-) (NP (NN His18-Pro19-Lys20-Phe21)) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT2_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_) (NNS _PROT2_) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT1_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NNS _PROT2_) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT1_) (NN _PROT1_) (NNS _PROT1_) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN work)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NP (ADJP (ADJP (JJ single)) (CC and) (ADJP (JJ double))) (NN Ala) (NNS substitutions)) (PP (IN of) (NP (NP (NN His18)) (CC and) (NP (NN Phe21)))) (PP (IN in) (NP (NN _PROT_)))) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 77-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (PP (TO to) (NP (NN _PROT_) (NN _PROT_) (NNS _PROT_) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN B)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (CC and) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NN Ala) (NNS mutants)) (VP (VP (VBD triggered) (NP (NN neutrophil) (NN degranulation))) (CC and) (VP (VBD induced) (NP (NP (NN calcium) (NNS responses)) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (JJ Single) (NN Asp)) (CC or) (NP (NN Ser))) (NNS substitutions)) (, ,) (NP (NP (NP (NNP H18D) (, ,) (NNP F21D)) (, ,) (NP (NNP F21S)) (, ,) (CC and) (NP (JJ double) (NNS substitutions))) (, ,) (NP (NNP H18A/F21D) (, ,) (NNP H18A/F21S)) (, ,) (CC and) (NP (NNP H18D/F21D))) (, ,)) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 431-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (JJ Single) (NN Asp)) (CC or) (NP (NN Ser))) (NNS substitutions)) (, ,) (NP (NP (NP (NNP H18D) (, ,) (NNP F21D)) (, ,) (NP (NNP F21S)) (, ,) (CC and) (NP (JJ double) (NNS substitutions))) (, ,) (NP (NNP H18A/F21D) (, ,) (NNP H18A/F21S)) (, ,) (CC and) (NP (NNP H18D/F21D))) (, ,)) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 431-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NP (JJ Single) (NN Asp)) (CC or) (NP (NN Ser))) (NNS substitutions)) (, ,) (NP (NP (NP (NNP H18D) (, ,) (NNP F21D)) (, ,) (NP (NNP F21S)) (, ,) (CC and) (NP (JJ double) (NNS substitutions))) (, ,) (NP (NNP H18A/F21D) (, ,) (NNP H18A/F21S)) (, ,) (CC and) (NP (NNP H18D/F21D))) (, ,)) (VP (VBD reduced) (PRT (RP up)) (S (VP (TO to) (ADVP (RB 431-fold)) (NP (NP (DT the) (NN binding) (NN affinity)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ recognizes)) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (JJ distinct) (NNS mechanisms)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ recognizes)) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (JJ distinct) (NNS mechanisms)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ recognizes)) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (JJ distinct) (NNS mechanisms)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ recognizes)) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (JJ distinct) (NNS mechanisms)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ recognizes)) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (JJ distinct) (NNS mechanisms)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ recognizes)) (CC and) (VP (VBZ activates) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (JJ distinct) (NNS mechanisms)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (JJ multiple) (NNS CC-chemokines)))) (: :) (S (NP (NN _PROT2_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (JJ natural) (NN antagonist)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (, ,) (CC and) (VP (VBD was) (ADVP (RB rapidly)) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (NP (DT the) (JJ main) (NN coreceptor)) (PP (IN for) (NP (JJ M-tropic) (NP (NP (JJ human) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN HIV)) (-RRB- -RRB-))) (CD -1) (NNS strains)))) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (, ,) (CC and) (VP (VBD was) (ADVP (RB rapidly)) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (NP (DT the) (JJ main) (NN coreceptor)) (PP (IN for) (NP (JJ M-tropic) (NP (NP (JJ human) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN HIV)) (-RRB- -RRB-))) (CD -1) (NNS strains)))) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (, ,) (CC and) (VP (VBD was) (ADVP (RB rapidly)) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (NP (DT the) (JJ main) (NN coreceptor)) (PP (IN for) (NP (JJ M-tropic) (NP (NP (JJ human) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN HIV)) (-RRB- -RRB-))) (CD -1) (NNS strains)))) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))))) (, ,) (CC and) (VP (VBD was) (ADVP (RB rapidly)) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (NP (DT the) (JJ main) (NN coreceptor)) (PP (IN for) (NP (JJ M-tropic) (NP (NP (JJ human) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN HIV)) (-RRB- -RRB-))) (CD -1) (NNS strains)))) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (, ,) (CC and) (VP (VBD was) (ADVP (RB rapidly)) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (NP (DT the) (JJ main) (NN coreceptor)) (PP (IN for) (NP (JJ M-tropic) (NP (NP (JJ human) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN HIV)) (-RRB- -RRB-))) (CD -1) (NNS strains)))) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBD was) (ADVP (RB first)) (VP (VBN characterized) (PP (IN as) (NP (NP (DT a) (NN receptor)) (PP (IN for) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))))))) (, ,) (CC and) (VP (VBD was) (ADVP (RB rapidly)) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (NP (NP (NP (DT the) (JJ main) (NN coreceptor)) (PP (IN for) (NP (JJ M-tropic) (NP (NP (JJ human) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN HIV)) (-RRB- -RRB-))) (CD -1) (NNS strains)))) (CC and) (NP (NP (JJ simian) (NN immunodeficiency) (NN virus)) (PRN (-LRB- -LRB-) (NP (NN SIV)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT All) (NNS CC-chemokines)) (ADJP (RB currently) (JJ available))) (VP (VBD were) (VP (VBN tested) (PP (IN for) (NP (PRP$ their) (NN ability) (S (S (VP (TO to) (VP (VB compete) (PP (IN with) (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125) (-RRB- -RRB-) (CD I)) (-RRB- -RSB-)) (NN _PROT1_) (NN binding))) (PP (IN on) (NP (NP (DT a) (JJ stable) (NN cell) (NN line)) (VP (VBG expressing) (NP (JJ recombinant) (NN _PROT2_)))))))) (, ,) (CC and/or) (S (VP (TO to) (VP (VB induce) (NP (DT a) (JJ functional) (NN response)) (PP (IN in) (NP (DT these) (NNS cells)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT2_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT2_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT2_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT1_) (NN binding)) (: :) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT1_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT1_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT1_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT1_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD found) (SBAR (IN that) (S (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))))) (, ,) (NP (CD five) (JJ other) (NNS CC-chemokines)) (VP (MD could) (VP (VB compete) (S (IN for) (S (NP (NP (-LRB- -LSB-) (PRN (-LRB- -LRB-) (NP (CD 125)) (-RRB- -RRB-)) (NN I) (-RRB- -RSB-) (NN _PROT_) (NN binding)) (: :) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN binding))) (VP (VBD was) (VP (VBN characterized) (PP (IN by) (NP (NP (NN IC) (-LRB- -LRB-) (CD 50) (-RRB- -RRB-) (NNS values)) (PP (IN of) (NP (QP (CD 0.22) (, ,) (CD 2.14) (, ,) (CD 5.89) (, ,) (CD 29.9) (, ,) (CC and) (CD 21.7)) (NN nmol/L))) (, ,) (ADVP (RB respectively)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT1_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT2_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT1_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT2_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT1_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT1_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT2_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT1_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT1_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT2_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT1_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT1_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT2_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT1_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT1_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT1_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT2_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT1_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT2_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN Among) (NP (DT these) (NNS ligands))) (, ,) (NP (NN _PROT_)) (VP (VBD had) (NP (NP (DT the) (JJ remarkable) (NN property)) (PP (IN of) (NP (NP (NN binding) (NN _PROT_)) (PP (IN with) (NP (JJ high) (NN affinity)))))) (PP (IN without) (S (VP (VBG eliciting) (NP (NP (DT a) (JJ functional) (NN response)) (, ,) (S (NP (NN _PROT_)) (VP (VP (MD could) (ADVP (RB also)) (VP (VB inhibit) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT1_)))))) (CC and) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (VP (VBN considered) (PP (IN as) (NP (NP (DT a) (JJ natural) (NN antagonist)) (PP (IN for) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT1_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT2_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT1_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT2_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT1_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT2_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT1_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT1_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT2_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT1_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT2_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT1_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT1_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT2_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT1_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NNS Chemokines)) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB compete) (PP (IN with) (NP (JJ high) (NN affinity))) (PP (IN for) (NP (NN _PROT_) (NN binding)))))))) (VP (MD could) (ADVP (RB also)) (VP (VB compete) (PP (IN for) (NP (JJ monomeric) (NN _PROT_) (NN binding))) (, ,) (ADVP (IN although) (PP (IN with) (NP (JJ variable) (NNS potencies))))))) (: ;) (S (NP (JJ maximal) (NN _PROT_) (NN binding) (NN inhibition)) (VP (VBD was) (NP (NP (NP (CD 80) (NN %)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (CONJP (CC but) (RB only)) (NP (NP (CD 30) (NN %)) (PP (IN for) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (MD could) (VP (VB compete) (ADVP (RB efficiently)) (PP (IN for) (NP (NN _PROT2_) (NN binding))))) (CC but) (VP (VBD was) (, ,) (ADVP (RB however)) (, ,) (VP (VBN found) (S (VP (TO to) (VP (VB be) (NP (NP (DT a) (JJ weak) (NN inhibitor)) (PP (IN of) (NP (NN HIV) (NN infection)))) (, ,) (PP (ADVP (RB probably)) (IN as) (NP (NP (DT a) (NN consequence)) (PP (IN of) (NP (PRP$ its) (NN inability) (S (VP (TO to) (VP (VB downregulate) (NP (DT the) (NN receptor)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT1_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT1_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT1_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT2_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT1_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT2_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT2_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (NP (DT the) (JJ individual) (NN amino) (NNS acids)) (PP (IN in) (NP (NP (NN _PROT_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (CC and) (NP (NP (DT those)) (PP (IN in) (NP (NP (NN _PROT1_)) (VP (VBN involved) (PP (IN in) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))) (VP (VBP have) (VP (VBN been) (VP (VBN mapped) (PP (IN in) (NP (DT this) (NN domain)))))))) (, ,) (NP (NP (DT the) (NN Trk) (NN amino) (NNS acids)) (SBAR (WHNP (WDT that)) (S (VP (VBP provide) (NP (NN specificity)))))) (VP (VBD remained) (ADJP (JJ unclear)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (NP (DT a) (JJ minimum) (NN set)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (NP (DT the) (JJ human) (JJ _PROT1_) (JJ second) (JJ immunoglobulin-like) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB bind) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,)))))) (VP (VBD were) (VP (VBN substituted) (PP (IN with) (NP (NP (DT those)) (PP (IN from) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (NP (DT a) (JJ minimum) (NN set)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (NP (DT the) (JJ human) (JJ _PROT1_) (JJ second) (JJ immunoglobulin-like) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB bind) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (, ,)))))) (VP (VBD were) (VP (VBN substituted) (PP (IN with) (NP (NP (DT those)) (PP (IN from) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (NP (DT a) (JJ minimum) (NN set)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (NP (DT the) (JJ human) (JJ _PROT1_) (JJ second) (JJ immunoglobulin-like) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB bind) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,)))))) (VP (VBD were) (VP (VBN substituted) (PP (IN with) (NP (NP (DT those)) (PP (IN from) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (NP (DT a) (JJ minimum) (NN set)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (NP (DT the) (JJ human) (JJ _PROT_) (JJ second) (JJ immunoglobulin-like) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB bind) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (, ,)))))) (VP (VBD were) (VP (VBN substituted) (PP (IN with) (NP (NP (DT those)) (PP (IN from) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (NP (DT a) (JJ minimum) (NN set)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (NP (DT the) (JJ human) (JJ _PROT_) (JJ second) (JJ immunoglobulin-like) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB bind) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,)))))) (VP (VBD were) (VP (VBN substituted) (PP (IN with) (NP (NP (DT those)) (PP (IN from) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (NP (DT a) (JJ minimum) (NN set)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (NP (DT the) (JJ human) (JJ _PROT_) (JJ second) (JJ immunoglobulin-like) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB bind) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (, ,)))))) (VP (VBD were) (VP (VBN substituted) (PP (IN with) (NP (NP (DT those)) (PP (IN from) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN equivalent))) (PP (TO to) (NP (NN _PROT2_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT2_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT2_) (NN _PROT2_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT1_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT2_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT1_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT1_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT2_) (NN _PROT2_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT1_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT1_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT2_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT1_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT2_) (NN _PROT2_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT1_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT1_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT2_) (NN _PROT2_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT1_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT_) (NN _PROT_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (VBG resulting) (NN Trk) (NN variant)) (VP (VP (VBN recruited) (NP (NP (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN equivalent))) (PP (TO to) (NP (NN _PROT_))))) (, ,) (VP (VBN maintained) (NP (NP (NN _PROT_) (NN binding)) (ADJP (JJ equivalent) (PP (TO to) (NP (NN _PROT_)))))) (, ,) (CC and) (ADVP (RB also)) (VP (VBD bound) (NP (JJ _PROT1_) (NN _PROT1_)) (, ,) (SBAR (IN although) (S (VP (PP (IN with) (NP (JJR lower) (NN affinity))) (VBN compared) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (ADVP (RB physically)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT2_))) (PP (IN through) (NP (NN Src) (NN homology) (CD 3) (NNS domains))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (JJ second)) (PP (IN of) (NP (NP (DT a) (NN series)) (PP (IN of) (NP (NP (NNS experiments)) (VP (VBN designed) (S (VP (TO to) (VP (VB identify) (NP (ADJP (NN _PROT1_) (NN homology) (CD 3) (-LRB- -LRB-) (NN SH3) (-RRB- -RRB-) (JJ -binding)) (NNS molecules)))))))))))) (, ,) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN cloning)) (PP (IN of) (NP (NP (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN from) (NP (DT an) (NN HL60) (NN cDNA) (NN expression) (NN library))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (JJ second)) (PP (IN of) (NP (NP (DT a) (NN series)) (PP (IN of) (NP (NP (NNS experiments)) (VP (VBN designed) (S (VP (TO to) (VP (VB identify) (NP (ADJP (NN _PROT1_) (NN homology) (CD 3) (-LRB- -LRB-) (NN SH3) (-RRB- -RRB-) (JJ -binding)) (NNS molecules)))))))))))) (, ,) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN cloning)) (PP (IN of) (NP (NP (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN from) (NP (DT an) (NN HL60) (NN cDNA) (NN expression) (NN library))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (JJ second)) (PP (IN of) (NP (NP (DT a) (NN series)) (PP (IN of) (NP (NP (NNS experiments)) (VP (VBN designed) (S (VP (TO to) (VP (VB identify) (NP (ADJP (NN _PROT_) (NN homology) (CD 3) (-LRB- -LRB-) (NN SH3) (-RRB- -RRB-) (JJ -binding)) (NNS molecules)))))))))))) (, ,) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN cloning)) (PP (IN of) (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN from) (NP (DT an) (NN HL60) (NN cDNA) (NN expression) (NN library))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NNS Studies)) (ADVP (ADVP (FW in) (FW vivo)) (CC and) (ADVP (FW in) (FW vitro)))) (VP (VBD demonstrated) (NP (NP (DT a) (ADJP (RB highly) (JJ specific)) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NN SH3) (NNS domains)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (ADJP (FW In) (FW vitro)) (NN translation) (NNS studies)) (VP (VBD identified) (NP (DT the) (JJ 66-kDa) (NN protein)) (PP (IN as) (NP (NP (DT the) (NN protein) (NN product)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (CC and) (S (NP (JJ subcellular) (NN fractionation) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (RB mainly) (JJ present) (PP (IN in) (NP (DT the) (NN cytosol) (NN fraction)))) (, ,) (SBAR (IN although) (S (NP (JJ significant) (NNS amounts)) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ present) (PP (IN in) (NP (NP (NN membrane)) (CC and) (NP (JJ nuclear) (NNS fractions)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ main) (NN _PROT1_) (NN region)) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN association)) (PP (IN with) (NP (NN _PROT2_))))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB be) (NP (DT the) (JJ carboxy-terminal) (NN SH3) (NN domain)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ mitogenic) (NNS effects)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN _PROT1_) (NP (NN _PROT1_)))))) (VP (VBP are) (VP (VBN mediated) (PP (IN through) (NP (NN cell) (NN surface) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Immunoprecipitation) (NNS experiments)) (VP (VBG employing) (NP (DT a) (JJ polyclonal) (NN _PROT1_) (NN antibody)))) (VP (VBD provided) (NP (JJ further) (NN evidence) (SBAR (IN that) (S (NP (NP (DT the) (JJ 60-kDa) (NN protein)) (VP (VBN isolated) (PP (IN in) (NP (DT this) (NN study))))) (VP (VBD was) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Further)) (, ,) (NP (NP (JJ polyclonal) (NNS antibodies)) (PP (TO to) (NP (JJ human) (NN _PROT1_)))) (ADVP (RB significantly)) (VP (VBD inhibited) (NP (NP (DT the) (JJ mitogenic) (NN activity)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN on) (NP (JJ human) (NNS fibroblasts)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ has) (VP (VBN shown) (SBAR (IN that) (S (NP (NN cell) (NN surface) (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PP (IN _PROT2_) (NP (NP (NN _PROT2_)) (VP (VBG mediating) (NP (PRP$ its) (JJ mitogenic) (NN activity))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ potential) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NNS receptors))))) (VP (VBD revealed) (PP (IN by) (NP (NP (NN affinity) (NN crosslinking)) (CC and) (NP (NN immunoprecipitation)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ potential) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS receptors))))) (VP (VBD revealed) (PP (IN by) (NP (NP (NN affinity) (NN crosslinking)) (CC and) (NP (NN immunoprecipitation)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ potential) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT2_) (NNS receptors))))) (VP (VBD revealed) (PP (IN by) (NP (NP (NN affinity) (NN crosslinking)) (CC and) (NP (NN immunoprecipitation)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBZ binds) (ADVP (RB independently)) (PP (TO to) (NP (NP (CD two) (JJ transmembrane) (NNS receptors)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (S (NP (DT both)) (VP (VBD co-expressed) (PP (IN in) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ neuronal) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP respond) (PP (TO to) (NP (NN _PROT2_)))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP have) (VP (VBN utilized) (NP (NP (NN affinity) (NN crosslinking) (NNS agents)) (PP (IN with) (NP (NN 125I-NGF)))) (S (VP (TO to) (VP (VB detect) (NP (NP (DT an) (NN association)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS receptors)))) (PP (IN in) (NP (NP (NP (NP (JJ embryonic) (JJ spinal) (NN cord)) (CC and) (NP (NN brain))) (NNS tissues)) (VP (VBN enriched) (PP (IN in) (NP (DT the) (CD two) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT2_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT2_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT2_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT2_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT2_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT2_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT1_AND_PROT2_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT1_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT2_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT1_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT1_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT2_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT1_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NP (JJ multimeric) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (RB not) (VP (VBN detected) (PP (IN by) (NP (NN affinity) (NN crosslinking))))))) (, ,) (NP (NP (NN immunoprecipitation)) (PP (IN of) (NP (JJ cross-linked) (NN _PROT_) (NNS complexes))) (PP (IN with) (NP (JJ _PROT1_) (NNS antibodies)))) (VP (VBD resulted) (PP (IN in) (NP (NP (JJ selective) (NN immunoprecipitation)) (PP (IN of) (NP (VBN crosslinked) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS receptors)) (VP (MD can) (ADVP (RB potentially)) (VP (VB interact))))) (, ,) (CC and) (SBAR (IN that) (S (NP (PDT such) (DT an) (NN association)) (VP (MD may) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (JJ high) (NN affinity) (NN _PROT_) (NN binding) (NNS sites))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS receptors)) (VP (MD can) (ADVP (RB potentially)) (VP (VB interact))))) (, ,) (CC and) (SBAR (IN that) (S (NP (PDT such) (DT an) (NN association)) (VP (MD may) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (JJ high) (NN affinity) (NN _PROT2_) (NN binding) (NNS sites))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS receptors)) (VP (MD can) (ADVP (RB potentially)) (VP (VB interact))))) (, ,) (CC and) (SBAR (IN that) (S (NP (PDT such) (DT an) (NN association)) (VP (MD may) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (JJ high) (NN affinity) (NN _PROT2_) (NN binding) (NNS sites))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Mechanism)) (PP (IN of) (NP (NN CDK) (NN activation)))) (VP (VBN revealed) (PP (IN by) (NP (NP (DT the) (NN structure)) (PP (IN of) (NP (DT a) (NN _PROT1_AND_PROT2_) (NN complex))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN -ATP) (NN complex)))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN A) (NN resolution))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN -ATP) (NN complex)))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN A) (NN resolution))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN -ATP) (NN complex)))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (CD 2.3) (NN A) (NN resolution))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization)))) (PP (IN of) (NP (NP (DT a) (JJ human) (NN type) (NN II) (NN receptor)) (PP (IN for) (NP (NP (NP (NN BMPs)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (RB distantly) (JJ related) (PP (TO to) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_)) (PP (IN from) (NP (NN Caenorhabditis) (NNS elegans)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization)))) (PP (IN of) (NP (NP (DT a) (JJ human) (NN type) (NN II) (NN receptor)) (PP (IN for) (NP (NP (NP (NN BMPs)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (RB distantly) (JJ related) (PP (TO to) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (NN Caenorhabditis) (NNS elegans)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization)))) (PP (IN of) (NP (NP (DT a) (JJ human) (NN type) (NN II) (NN receptor)) (PP (IN for) (NP (NP (NP (NN BMPs)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (RB distantly) (JJ related) (PP (TO to) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (NN Caenorhabditis) (NNS elegans)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (VBN transfected) (NN COS-1) (NNS cells))) (, ,) (NP (NP (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_AND_PROT2_)) (, ,) (CC and) (ADVP (RBR less) (RB efficiently)) (NP (NN _PROT_)) (, ,)) (VP (VBD bound) (PP (TO to) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (VBN transfected) (NN COS-1) (NNS cells))) (, ,) (NP (NP (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)) (, ,) (CC and) (ADVP (RBR less) (RB efficiently)) (NP (NN _PROT2_)) (, ,)) (VP (VBD bound) (PP (TO to) (NP (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (VBN transfected) (NN COS-1) (NNS cells))) (, ,) (NP (NP (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)) (, ,) (CC and) (ADVP (RBR less) (RB efficiently)) (NP (NN _PROT_)) (, ,)) (VP (VBD bound) (PP (TO to) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (VBN transfected) (NN COS-1) (NNS cells))) (, ,) (NP (NP (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT1_)) (, ,) (CC and) (ADVP (RBR less) (RB efficiently)) (NP (NN _PROT2_)) (, ,)) (VP (VBD bound) (PP (TO to) (NP (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (VBN transfected) (NN COS-1) (NNS cells))) (, ,) (NP (NP (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT1_)) (, ,) (CC and) (ADVP (RBR less) (RB efficiently)) (NP (NN _PROT_)) (, ,)) (VP (VBD bound) (PP (TO to) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (VBN transfected) (NN COS-1) (NNS cells))) (, ,) (NP (NP (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (, ,) (CC and) (ADVP (RBR less) (RB efficiently)) (NP (NN _PROT1_)) (, ,)) (VP (VBD bound) (PP (TO to) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Binding)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_))) (PP (TO to) (NP (NN _PROT_)))) (VP (VBD was) (ADVP (RB also)) (VP (VBN observed) (PP (IN in) (NP (JJ nontransfected) (NN cell) (NNS lines)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VBD was) (ADVP (RB also)) (VP (VBN observed) (PP (IN in) (NP (JJ nontransfected) (NN cell) (NNS lines)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Binding)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VBD was) (ADVP (RB also)) (VP (VBN observed) (PP (IN in) (NP (JJ nontransfected) (NN cell) (NNS lines)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (DT a) (JJ transcriptional) (NN activation) (NN signal)) (VP (VBD was) (VP (VBN transduced) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN type) (CD I) (NP (NNS receptors)))) (PP (IN after) (NP (NP (NN stimulation)) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (DT a) (JJ transcriptional) (NN activation) (NN signal)) (VP (VBD was) (VP (VBN transduced) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN type) (CD I) (NP (NNS receptors)))) (PP (IN after) (NP (NP (NN stimulation)) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (DT a) (JJ transcriptional) (NN activation) (NN signal)) (VP (VBD was) (VP (VBN transduced) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN type) (CD I) (NP (NNS receptors)))) (PP (IN after) (NP (NP (NN stimulation)) (PP (IN by) (NP (NN _PROT1_AND_PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ heterodimeric) (NN bZIP) (NN transcription) (NN factor) (CD _PROT1_AND_PROT2_)))) (VP (VBD bound) (PP (TO to) (NP (NN DNA))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS families)) (PP (IN of) (NP (JJ eukaryotic) (NN transcription) (NNS factors)))) (VP (VBP heterodimerize) (S (VP (TO to) (VP (VB form) (NP (NP (NNS complexes)) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG binding) (NP (NN 5'-TGAGTCA-3) (POS ') (NN DNA) (NNS elements)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN determined) (NP (NP (DT the) (NN X-ray) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT a) (NN heterodimer)) (PP (IN of) (NP (NP (DT the) (NN bZIP) (NNS regions)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD bound) (PP (TO to) (NP (NN DNA)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Comparison)) (PP (IN of) (NP (DT the) (CD two) (ADJP (RB crystallographically) (JJ distinct)) (JJ protein-DNA) (NNS complexes)))) (VP (VBP show) (SBAR (SBAR (IN that) (S (NP (DT the) (JJ coiled-coil)) (VP (VBZ is) (ADVP (RB flexibly)) (VP (VBN joined) (PP (TO to) (NP (DT the) (JJ basic) (NNS regions))))))) (CC and) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_AND_PROT2_) (NN heterodimer)) (VP (VBZ does) (RB not) (VP (VB recognize) (NP (NP (DT the) (JJ asymmetric) (CD 5'-TGAGTCA-3) (`` ') (NN recognition) (NN element)) (PP (IN in) (NP (DT a) (JJ unique) (NN orientation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN protein) (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ key) (NN mediator)) (PP (IN of) (NP (NP (NN mitogenesis)) (CC and) (NP (NN differentiation))))) (, ,)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS refs) (CD 1-3)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS proteins)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (NN 14-3-3) (NN family)) (PP (IN of) (NP (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS proteins)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (NN 14-3-3) (NN family)) (PP (IN of) (NP (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS proteins)) (, ,) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (NN 14-3-3) (NN family)) (PP (IN of) (NP (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS proteins)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (NN 14-3-3) (NN family)) (PP (IN of) (NP (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS proteins)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (NN 14-3-3) (NN family)) (PP (IN of) (NP (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS proteins)) (, ,) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (VP (VBP are) (NP (NP (NNS members)) (PP (IN of) (NP (NP (DT the) (NN 14-3-3) (NN family)) (PP (IN of) (NP (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (NN 14-3-3) (NNS proteins))) (PP (IN in) (NP (NN Xenopus) (NNS oocytes)))) (VP (VP (VBD enhanced) (NP (NN _PROT1_) (NN activity))) (CC and) (VP (VBD promoted) (NP (JJ _PROT2_) (NN oocyte) (NN maturation))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN POU) (NNS domains)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NN transcription) (NNS factors)))) (VP (VBP mediate) (NP (NP (JJ specific) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN POU) (NNS domains)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NN transcription) (NNS factors)))) (VP (VBP mediate) (NP (NP (JJ specific) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN POU) (NNS domains)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NN transcription) (NNS factors)))) (VP (VBP mediate) (NP (NP (JJ specific) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD had) (ADVP (RB previously)) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (DT the) (JJ ubiquitous) (NN _PROT1_)) (CC and) (NP (DT the) (JJ lymphoid-specific) (NN _PROT2_)) (NP (NN transcription) (NNS factors))) (VP (VBP stimulate) (NP (NN transcription)) (PP (IN at) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (JJ stable) (NN preinitiation) (NN complex) (NN formation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB therefore)) (VP (VBN investigated) (SBAR (IN whether) (S (NP (DT the) (NN octamer) (NN binding) (NNS proteins)) (VP (MD might) (ADVP (RB physically)) (VP (VB interact) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN factor))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB therefore)) (VP (VBN investigated) (SBAR (IN whether) (S (NP (DT the) (NN octamer) (NN binding) (NNS proteins)) (VP (MD might) (ADVP (RB physically)) (VP (VB interact) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN factor))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB therefore)) (VP (VBN investigated) (SBAR (IN whether) (S (NP (DT the) (NN octamer) (NN binding) (NNS proteins)) (VP (MD might) (ADVP (RB physically)) (VP (VB interact) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN factor))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN By) (S (VP (VBG using) (NP (JJ several) (JJ different) (JJ experimental) (NNS systems))))) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB efficiently)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN By) (S (VP (VBG using) (NP (JJ several) (JJ different) (JJ experimental) (NNS systems))))) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB efficiently)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (S (VP (VBG using) (NP (JJ several) (JJ different) (JJ experimental) (NNS systems))))) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB efficiently)) (VP (VBZ associates) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NP (DT the) (NN POU) (NN homeodomain)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (ADJP (RB evolutionarily) (VBN conserved)) (JJ C-terminal) (NN core) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (VP (VBP are) (ADJP (CC both) (ADJP (JJ required)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (DT the) (NN interaction))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN POU) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (RB highly) (JJ homologous) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN POU) (NN domain))))))) (, ,)) (ADVP (RB likewise)) (VP (VBZ mediates) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN POU) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (RB highly) (JJ homologous) (PP (TO to) (NP (DT the) (NN _PROT_) (NN POU) (NN domain))))))) (, ,)) (ADVP (RB likewise)) (VP (VBZ mediates) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN POU) (NN domain)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (RB highly) (JJ homologous) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN POU) (NN domain))))))) (, ,)) (ADVP (RB likewise)) (VP (VBZ mediates) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN interaction)) (VP (MD can) (ADVP (RB also)) (VP (VB be) (VP (VBN observed) (ADVP (FW in) (FW vivo)) (, ,) (SBAR (IN as) (S (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB be) (VP (VBN co-precipitated) (PP (IN with) (NP (NN _PROT2_))) (PP (IN from) (NP (VBN co-transfected) (NN Cos1) (NNS cells))))))) (CC and) (S (NP (NN _PROT_)) (VP (VBZ co-immunoprecipitates) (PP (IN with) (NP (NP (DT the) (JJ endogenous) (NN _PROT_)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN interaction)) (VP (MD can) (ADVP (RB also)) (VP (VB be) (VP (VBN observed) (ADVP (FW in) (FW vivo)) (, ,) (SBAR (IN as) (S (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB be) (VP (VBN co-precipitated) (PP (IN with) (NP (NN _PROT_))) (PP (IN from) (NP (VBN co-transfected) (NN Cos1) (NNS cells))))))) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ co-immunoprecipitates) (PP (IN with) (NP (NP (DT the) (JJ endogenous) (NN _PROT_)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN interaction)) (VP (MD can) (ADVP (RB also)) (VP (VB be) (VP (VBN observed) (ADVP (FW in) (FW vivo)) (, ,) (SBAR (IN as) (S (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB be) (VP (VBN co-precipitated) (PP (IN with) (NP (NN _PROT_))) (PP (IN from) (NP (VBN co-transfected) (NN Cos1) (NNS cells))))))) (CC and) (S (NP (NN _PROT_)) (VP (VBZ co-immunoprecipitates) (PP (IN with) (NP (NP (DT the) (JJ endogenous) (NN _PROT2_)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN interaction)) (VP (MD can) (ADVP (RB also)) (VP (VB be) (VP (VBN observed) (ADVP (FW in) (FW vivo)) (, ,) (SBAR (IN as) (S (S (NP (NN _PROT_)) (VP (MD can) (VP (VB be) (VP (VBN co-precipitated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN from) (NP (VBN co-transfected) (NN Cos1) (NNS cells))))))) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ co-immunoprecipitates) (PP (IN with) (NP (NP (DT the) (JJ endogenous) (NN _PROT_)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN interaction)) (VP (MD can) (ADVP (RB also)) (VP (VB be) (VP (VBN observed) (ADVP (FW in) (FW vivo)) (, ,) (SBAR (IN as) (S (S (NP (NN _PROT_)) (VP (MD can) (VP (VB be) (VP (VBN co-precipitated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN from) (NP (VBN co-transfected) (NN Cos1) (NNS cells))))))) (CC and) (S (NP (NN _PROT_)) (VP (VBZ co-immunoprecipitates) (PP (IN with) (NP (NP (DT the) (JJ endogenous) (NN _PROT2_)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN interaction)) (VP (MD can) (ADVP (RB also)) (VP (VB be) (VP (VBN observed) (ADVP (FW in) (FW vivo)) (, ,) (SBAR (IN as) (S (S (NP (NN _PROT_)) (VP (MD can) (VP (VB be) (VP (VBN co-precipitated) (PP (IN with) (NP (NN _PROT_))) (PP (IN from) (NP (VBN co-transfected) (NN Cos1) (NNS cells))))))) (CC and) (S (NP (NN _PROT1_)) (VP (VBZ co-immunoprecipitates) (PP (IN with) (NP (NP (DT the) (JJ endogenous) (NN _PROT2_)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-transfection)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN expression) (NNS vectors)))) (PP (IN into) (NP (NN B) (NNS cells)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ synergistic) (NN activation)) (PP (IN of) (NP (NP (DT an) (NN octamer) (NN motif)) (VP (VBG containing) (NP (NN promoter))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Regulation)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN transcription) (NN factor) (NN _PROT2_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (DT the) (NN _PROT_) (NN protein)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Regulation)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN transcription) (NN factor) (NN _PROT_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN protein)))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Regulation)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN transcription) (NN factor) (NN _PROT1_))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN protein)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ nuclear) (NN phosphoprotein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (NN cell) (NN cycle) (NN progression)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ lymphoid-specific) (NN _PROT2_) (NN transcription) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ regulates) (NP (JJ inducible) (NN gene) (NN expression)) (PP (IN during) (NP (NN T) (NN cell) (NN activation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN report))) (, ,) (NP (PRP it)) (VP (VBZ is) (VP (VBN demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT a) (NN sequence) (NN motif)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ is) (ADJP (RB highly) (JJ related) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN binding) (NNS sites)) (PP (IN of) (NP (JJ several) (JJ viral) (NNS oncoproteins))))))) (CC and) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN pocket) (NN region)) (PP (IN of) (NP (NN _PROT_))))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN report))) (, ,) (NP (PRP it)) (VP (VBZ is) (VP (VBN demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (DT a) (NN sequence) (NN motif)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ is) (ADJP (RB highly) (JJ related) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN binding) (NNS sites)) (PP (IN of) (NP (JJ several) (JJ viral) (NNS oncoproteins))))))) (CC and) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN pocket) (NN region)) (PP (IN of) (NP (NN _PROT2_))))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN report))) (, ,) (NP (PRP it)) (VP (VBZ is) (VP (VBN demonstrated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ contains) (NP (NP (DT a) (NN sequence) (NN motif)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ is) (ADJP (RB highly) (JJ related) (PP (TO to) (NP (NP (DT the) (NN _PROT1_) (NN binding) (NNS sites)) (PP (IN of) (NP (JJ several) (JJ viral) (NNS oncoproteins))))))) (CC and) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN pocket) (NN region)) (PP (IN of) (NP (NN _PROT2_))))) (ADVP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB exclusively)) (PP (TO to) (NP (NP (DT the) (JJ underphosphorylated) (NN form)) (PP (IN of) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ fails) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NN _PROT_) (NNS mutants)) (VP (VBN derived) (PP (IN from) (NP (NP (NNS patients)) (PP (IN with) (NP (NN retinoblastoma)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB exclusively)) (PP (TO to) (NP (NP (DT the) (JJ underphosphorylated) (NN form)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (VP (VBZ fails) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NN _PROT2_) (NNS mutants)) (VP (VBN derived) (PP (IN from) (NP (NP (NNS patients)) (PP (IN with) (NP (NN retinoblastoma)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB exclusively)) (PP (TO to) (NP (NP (DT the) (JJ underphosphorylated) (NN form)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (VP (VBZ fails) (S (VP (TO to) (VP (VB bind) (PP (TO to) (NP (NP (NN _PROT2_) (NNS mutants)) (VP (VBN derived) (PP (IN from) (NP (NP (NNS patients)) (PP (IN with) (NP (NN retinoblastoma)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Co-immunoprecipitation) (NNS experiments)) (VP (VBD demonstrated) (NP (NP (DT an) (NN association)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (VBG resting) (JJ normal) (JJ human) (NN T) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN After) (NP (NN T) (NN cell) (NN activation))) (, ,) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN correlated) (ADVP (RB temporally)) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN After) (NP (NN T) (NN cell) (NN activation))) (, ,) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN correlated) (ADVP (RB temporally)) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN After) (NP (NN T) (NN cell) (NN activation))) (, ,) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ results) (PP (IN in) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN correlated) (ADVP (RB temporally)) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NP (DT a) (JJ phosphorylation-defective) (NN form)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBD inhibited) (NP (JJ _PROT2_) (NN transcription)) (PP (IN during) (NP (NN T) (NN cell) (NN activation))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ interacts) (ADVP (RB specifically)) (PP (IN with) (NP (DT a) (JJ lineage-restricted) (NN _PROT2_) (NN transcription) (NN factor)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (ADJP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (ADVP (RB specifically)) (VP (VBZ recognizes) (NP (NP (DT the) (NNS PSEs)) (PP (IN of) (NP (CC both) (NP (NN RNA) (NN polymerase) (NN II-)) (CC and) (NP (ADJP (NN RNA) (NN polymerase) (JJ III-transcribed)) (NP (NP (JJ small) (JJ nuclear) (NN RNA)) (PRN (-LRB- -LRB-) (NP (NN snRNA)) (-RRB- -RRB-))) (NNS genes))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (VP (VBN purified) (PP (IN from) (NP (JJ human) (NN HeLa) (NNS cells))))) (VP (VBZ is) (NP (NP (DT a) (JJ multisubunit) (NN complex)) (PP (IN of) (NP (NP (CD four) (NNS polypeptides)) (VP (VBN designated) (S (NP (NP (NN _PROT2_) (NN _PROT_)) (, ,) (NP (NN -beta)) (, ,) (NP (NN -gamma)) (, ,) (CC and) (NP (NN -delta)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (VP (VBN purified) (PP (IN from) (NP (JJ human) (NN HeLa) (NNS cells))))) (VP (VBZ is) (NP (NP (DT a) (JJ multisubunit) (NN complex)) (PP (IN of) (NP (NP (CD four) (NNS polypeptides)) (VP (VBN designated) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN -beta)) (, ,) (NP (NN -gamma)) (, ,) (CC and) (NP (NN -delta)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (VP (VBN purified) (PP (IN from) (NP (JJ human) (NN HeLa) (NNS cells))))) (VP (VBZ is) (NP (NP (DT a) (JJ multisubunit) (NN complex)) (PP (IN of) (NP (NP (CD four) (NNS polypeptides)) (VP (VBN designated) (S (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (, ,) (NP (NN -beta)) (, ,) (NP (NN -gamma)) (, ,) (CC and) (NP (NN -delta)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP report) (NP (NP (NP (DT the) (NP (NP (NN isolation)) (CC and) (NP (NN expression)))) (PP (IN of) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (NP (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT2_) (NN delta))))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ functional) (NNS studies)) (PP (IN with) (NP (NP (JJ cognate) (NNS antibodies)) (SBAR (WHNP (WDT that)) (S (VP (VBP recognize) (NP (DT the) (JJ native) (NN _PROT_) (NN complex)) (PP (IN in) (NP (NN HeLa) (NNS extracts)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP report) (NP (NP (NP (DT the) (NP (NP (NN isolation)) (CC and) (NP (NN expression)))) (PP (IN of) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (NP (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta))))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ functional) (NNS studies)) (PP (IN with) (NP (NP (JJ cognate) (NNS antibodies)) (SBAR (WHNP (WDT that)) (S (VP (VBP recognize) (NP (DT the) (JJ native) (NN _PROT2_) (NN complex)) (PP (IN in) (NP (NN HeLa) (NNS extracts)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP report) (NP (NP (NP (DT the) (NP (NP (NN isolation)) (CC and) (NP (NN expression)))) (PP (IN of) (NP (NP (NNS cDNAs)) (VP (VBG encoding) (NP (NP (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta))))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ functional) (NNS studies)) (PP (IN with) (NP (NP (JJ cognate) (NNS antibodies)) (SBAR (WHNP (WDT that)) (S (VP (VBP recognize) (NP (DT the) (JJ native) (NN _PROT2_) (NN complex)) (PP (IN in) (NP (NN HeLa) (NNS extracts)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS studies)) (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (DT the) (CD four) (NN _PROT1_) (NNS subunits)) (VP (ADVP (RB originally)) (VBN found) (S (VP (TO to) (VP (VB copurify) (PP (IN during) (NP (JJ conventional) (NN chromatography))) (ADVP (RB indeed)) (PP (IN form) (NP (DT a) (ADJP (RB tightly) (VBN associated)) (NN complex)))))))))))) (: ;) (S (NP (PRP they)) (ADVP (RB further)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NP (DT the) (NN _PROT2_)) (ADJP (RB so) (VBN defined))) (, ,) (PP (VBG including) (NP (NP (DT the) (NP (NP (NN gamma)) (CC and) (NP (NN delta))) (NNS subunits)) (ADVP (RB specifically)))) (, ,)) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (NN transcription)) (PP (IN of) (NP (CC both) (NP (NN class) (CD II)) (CC and) (NP (NN class) (CD III)) (NP (NN snRNA) (NNS genes)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT2_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT2_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT2_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT2_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT2_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT1_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT1_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT1_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT1_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Immunoprecipitation) (NNS assays)) (ADVP (RB also)) (VP (VBP show) (NP (NP (DT a) (JJ weak) (JJ substoichiometric) (NN association)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (JJ previous) (NN report)) (PP (IN of) (NP (NP (NP (DT a) (JJ _PROT_) (NN complex)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBG containing) (NP (NP (JJ substoichiometric) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT a) (NN component)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (ADJP (JJ identical) (PP (IN in) (NP (NN sequence))) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN gamma)) (VP (VBN reported) (ADVP (RB here)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT2_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT2_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT1_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT2_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT1_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT1_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT1_AND_PROT2_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT1_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT1_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT1_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT2_)) (CC and) (NP (JJ TATA-bound) (NN _PROT_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT1_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Glutathione) (NN S-transferase)) (JJ pulldown) (NNS assays)) (ADVP (RB further)) (VP (VBP indicate) (NP (NP (ADJP (RB relatively) (JJ strong)) (JJ direct) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (JJ recombinant) (NN _PROT_) (NN gamma)) (CC and) (NP (NN _PROT_) (NN delta)))) (PP (IN with) (NP (NN _PROT_)))) (, ,) (S (ADJP (JJ consistent) (PP (CC either) (PP (IN with) (NP (NP (DT the) (JJ natural) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (DT a) (JJ semistable) (JJ _PROT_) (NN factor) (NN complex))))) (CC or) (PP (IN with) (NP (NP (JJ possible) (JJ functional) (NNS interactions)) (PP (IN between) (NP (NP (NP (JJ PSE-bound) (NN _PROT1_)) (CC and) (NP (JJ TATA-bound) (NN _PROT2_))) (PP (IN during) (NP (NN promoter) (NN activation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT2_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT2_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT2_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT1_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT2_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT1_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT2_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT2_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (PP (IN in) (NP (NP (NNS extracts)) (VP (VBN depleted) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (NNS factors))))))) (, ,) (NP (NP (NN transcription)) (PP (IN from) (NP (DT the) (NN U1) (NN promoter)))) (VP (VBZ is) (VP (VBN restored) (PP (PP (IN by) (NP (JJ recombinant) (NN _PROT_))) (CC but) (PP (RB not) (IN by) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (NN transcription)) (PP (IN of) (NP (NN class) (CD II) (NN snRNA) (NNS genes)))) (VP (VBZ requires) (NP (NP (DT a) (NN _PROT2_) (NN complex)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT the) (NN one)) (VP (VBN used) (PP (IN for) (NP (JJ mRNA-encoding) (NNS genes)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CD _PROT1_) (NN glucose) (NN transporter)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CD _PROT1_) (NN glucose) (NN transporter)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CD _PROT_) (NN glucose) (NN transporter)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (VBN truncated) (NN version)) (PP (IN of) (NP (NP (DT the) (JJ integral) (NN membrane) (NN glycoprotein)) (NP (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN synthesized) (PP (IN in) (NP (DT a) (NN rabbit) (NN reticulocyte) (NN translation) (NN system))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ canine) (JJ pancreatic) (NNS microsomes)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (VBG Following) (NP (NP (NN immunoprecipitation)) (PP (IN with) (NP (DT an) (NN anticalnexin) (NN antiserum))))) (, ,) (NP (DT a) (JJ cross-linker-independent) (NN association)) (VP (VBD was) (VP (VBN observed) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (DT the) (NN anti-calnexin) (NN antiserum)) (VP (VBD immunoprecipitated) (NP (NP (DT a) (JJ UV-dependent) (NN cross-linking) (NN product)) (VP (VBG consisting) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (QP (RB approximately) (CD 60)) (NN kDa)))) (VP (VBN designated) (S (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT_) (NN _PROT_)) (PP (IN of) (NP (CD 60) (NN kDa)))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (DT the) (NN anti-calnexin) (NN antiserum)) (VP (VBD immunoprecipitated) (NP (NP (DT a) (JJ UV-dependent) (NN cross-linking) (NN product)) (VP (VBG consisting) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (QP (RB approximately) (CD 60)) (NN kDa)))) (VP (VBN designated) (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PP (IN of) (NP (CD 60) (NN kDa)))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (DT the) (NN anti-calnexin) (NN antiserum)) (VP (VBD immunoprecipitated) (NP (NP (DT a) (JJ UV-dependent) (NN cross-linking) (NN product)) (VP (VBG consisting) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (QP (RB approximately) (CD 60)) (NN kDa)))) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PP (IN of) (NP (CD 60) (NN kDa)))) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_AND_PROT2_)) (CC and) (NP (DT the) (CD _PROT_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT2_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT2_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT2_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT2_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT2_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (CD _PROT_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT2_) (NNS interactions))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (CD _PROT1_AND_PROT2_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (CD _PROT1_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (CD _PROT1_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT2_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (CD _PROT1_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (CD _PROT1_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT2_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (CD _PROT_) (NNS interactions))) (VP (VBD were) (ADJP (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group)) (PP (IN on) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN characteristic)) (PP (IN of) (NP (JJ many) (NN _PROT2_) (NNS interactions))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT A) (NN _PROT1_) (NN mutant)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (RB not) (VP (VBN glycosylated)))))) (PRN (-LRB- -LRB-) (NP (NN AGGT155)) (-RRB- -RRB-))) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT A) (NN _PROT1_) (NN mutant)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (RB not) (VP (VBN glycosylated)))))) (PRN (-LRB- -LRB-) (NP (NN AGGT155)) (-RRB- -RRB-))) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT A) (NN _PROT_) (NN mutant)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (RB not) (VP (VBN glycosylated)))))) (PRN (-LRB- -LRB-) (NP (NN AGGT155)) (-RRB- -RRB-))) (VP (VBD did) (RB not) (VP (VB associate) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (JJ soluble) (NN homologue)) (PP (IN of) (NP (NN _PROT2_)))) (, ,)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (DT the) (NN protein)) (VP (VBD bore) (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (JJ soluble) (NN homologue)) (PP (IN of) (NP (NN _PROT_)))) (, ,)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (DT the) (NN protein)) (VP (VBD bore) (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT the) (JJ soluble) (NN homologue)) (PP (IN of) (NP (NN _PROT1_)))) (, ,)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (DT the) (NN protein)) (VP (VBD bore) (NP (DT a) (ADJP (RB correctly) (VBN modified)) (NN oligosaccharide) (NN group))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP interact) (PP (IN with) (NP (NN _PROT_) (CD _PROT_))) (PP (IN in) (NP (DT a) (JJ glycosylation-dependent) (NN manner)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_) (CD _PROT2_))) (PP (IN in) (NP (DT a) (JJ glycosylation-dependent) (NN manner)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP show) (SBAR (IN that) (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_) (CD _PROT2_))) (PP (IN in) (NP (DT a) (JJ glycosylation-dependent) (NN manner)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ _PROT1_AND_PROT2_) (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (: :) (NP (NP (DT a) (ADJP (ADJP (JJ ligand)) (CC and) (ADJP (JJ specific))) (NN activator)) (PP (IN of) (NP (DT the) (NN tyrosine) (NN kinase) (NN receptor) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT_)) (: :) (NP (NP (DT a) (ADJP (ADJP (JJ ligand)) (CC and) (ADJP (JJ specific))) (NN activator)) (PP (IN of) (NP (DT the) (NN tyrosine) (NN kinase) (NN receptor) (NN _PROT2_)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (: :) (NP (NP (DT a) (ADJP (ADJP (JJ ligand)) (CC and) (ADJP (JJ specific))) (NN activator)) (PP (IN of) (NP (DT the) (NN tyrosine) (NN kinase) (NN receptor) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (CC or) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ endothelial) (JJ cell-specific) (NNS receptors)) (PP (IN with) (NP (NP (CD seven) (JJ immunoglobulin-like) (NNS domains)) (CC and) (NP (DT a) (JJ split) (NN kinase) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (CC or) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ endothelial) (JJ cell-specific) (NNS receptors)) (PP (IN with) (NP (NP (CD seven) (JJ immunoglobulin-like) (NNS domains)) (CC and) (NP (DT a) (JJ split) (NN kinase) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (CC or) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ endothelial) (JJ cell-specific) (NNS receptors)) (PP (IN with) (NP (NP (CD seven) (JJ immunoglobulin-like) (NNS domains)) (CC and) (NP (DT a) (JJ split) (NN kinase) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (CC or) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ endothelial) (JJ cell-specific) (NNS receptors)) (PP (IN with) (NP (NP (CD seven) (JJ immunoglobulin-like) (NNS domains)) (CC and) (NP (DT a) (JJ split) (NN kinase) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (CC or) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ endothelial) (JJ cell-specific) (NNS receptors)) (PP (IN with) (NP (NP (CD seven) (JJ immunoglobulin-like) (NNS domains)) (CC and) (NP (DT a) (JJ split) (NN kinase) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN tyrosine) (NNS kinases)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (CC or) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBP constitute) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ endothelial) (JJ cell-specific) (NNS receptors)) (PP (IN with) (NP (NP (CD seven) (JJ immunoglobulin-like) (NNS domains)) (CC and) (NP (DT a) (JJ split) (NN kinase) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB play) (NP (JJ key) (NNS roles)) (PP (IN in) (NP (JJ vascular) (NN development)))))))))) (: ;) (S (NP (DT these) (CD two) (NNS receptors)) (VP (VP (VBP bind)) (CC and) (VP (VBP are) (VP (VBN activated) (PP (IN by) (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB play) (NP (JJ key) (NNS roles)) (PP (IN in) (NP (JJ vascular) (NN development)))))))))) (: ;) (S (NP (DT these) (CD two) (NNS receptors)) (VP (VP (VBP bind)) (CC and) (VP (VBP are) (VP (VBN activated) (PP (IN by) (NP (NP (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB play) (NP (JJ key) (NNS roles)) (PP (IN in) (NP (JJ vascular) (NN development)))))))))) (: ;) (S (NP (DT these) (CD two) (NNS receptors)) (VP (VP (VBP bind)) (CC and) (VP (VBP are) (VP (VBN activated) (PP (IN by) (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB play) (NP (JJ key) (NNS roles)) (PP (IN in) (NP (JJ vascular) (NN development)))))))))) (: ;) (S (NP (DT these) (CD two) (NNS receptors)) (VP (VP (VBP bind)) (CC and) (VP (VBP are) (VP (VBN activated) (PP (IN by) (NP (NP (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB play) (NP (JJ key) (NNS roles)) (PP (IN in) (NP (JJ vascular) (NN development)))))))))) (: ;) (S (NP (DT these) (CD two) (NNS receptors)) (VP (VP (VBP bind)) (CC and) (VP (VBP are) (VP (VBN activated) (PP (IN by) (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB play) (NP (JJ key) (NNS roles)) (PP (IN in) (NP (JJ vascular) (NN development)))))))))) (: ;) (S (NP (DT these) (CD two) (NNS receptors)) (VP (VP (VBP bind)) (CC and) (VP (VBP are) (VP (VBN activated) (PP (IN by) (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN protein)) (, ,) (VP (VBN designated) (S (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (, ,)) (ADVP (RB specifically)) (VP (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (VP (VBZ stimulates) (NP (NP (DT the) (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (, ,) (CC and) (VP (VBZ promotes) (NP (NP (DT the) (NN mitogenesis)) (PP (IN of) (NP (JJ human) (NN lung) (JJ endothelial) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ fails) (S (VP (TO to) (VP (VB bind) (ADVP (RB appreciably)) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ fails) (S (VP (TO to) (VP (VB bind) (ADVP (RB appreciably)) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ fails) (S (VP (TO to) (VP (VB bind) (ADVP (RB appreciably)) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN substrate)) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NP (NP (NN growth)) (CC and) (NP (NN plasticity)))) (PP (IN of) (NP (JJ neuronal) (NNS connections))))))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (JJ several) (NN signal) (NN transduction) (NNS pathways))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ yeast-based) (NN cloning) (NN system))) (, ,) (NP (NP (DT the) (JJ only) (JJ strong) (NN interaction)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN detected) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ yeast-based) (NN cloning) (NN system))) (, ,) (NP (NP (DT the) (JJ only) (JJ strong) (NN interaction)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN detected) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ yeast-based) (NN cloning) (NN system))) (, ,) (NP (NP (DT the) (JJ only) (JJ strong) (NN interaction)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN detected) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ yeast-based) (NN cloning) (NN system))) (, ,) (NP (NP (DT the) (JJ only) (JJ strong) (NN interaction)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN detected) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ yeast-based) (NN cloning) (NN system))) (, ,) (NP (NP (DT the) (JJ only) (JJ strong) (NN interaction)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN detected) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ yeast-based) (NN cloning) (NN system))) (, ,) (NP (NP (DT the) (JJ only) (JJ strong) (NN interaction)) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (VP (VBN detected) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ phosphorylates) (NP (NN _PROT2_)) (PP (IN on) (NP (NN serine) (CD 41))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Surprisingly)) (, ,) (NP (NP (DT the) (JJ N-terminal) (JJ third)) (PP (IN of) (NP (NN _PROT1_)))) (ADVP (RB alone)) (VP (VBD bound) (NP (NN _PROT2_)) (ADVP (ADVP (RBR more) (RB strongly)) (SBAR (IN than) (SINV (VBD did) (NP (JJ intact) (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN protein) (POS 's)) (NN C-terminus)) (VP (MD may) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (S (VP (VBG modulating) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Surprisingly)) (, ,) (NP (NP (DT the) (JJ N-terminal) (JJ third)) (PP (IN of) (NP (NN _PROT1_)))) (ADVP (RB alone)) (VP (VBD bound) (NP (NN _PROT_)) (ADVP (ADVP (RBR more) (RB strongly)) (SBAR (IN than) (SINV (VBD did) (NP (JJ intact) (NN _PROT2_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN protein) (POS 's)) (NN C-terminus)) (VP (MD may) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (S (VP (VBG modulating) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Surprisingly)) (, ,) (NP (NP (DT the) (JJ N-terminal) (JJ third)) (PP (IN of) (NP (NN _PROT1_)))) (ADVP (RB alone)) (VP (VBD bound) (NP (NN _PROT_)) (ADVP (ADVP (RBR more) (RB strongly)) (SBAR (IN than) (SINV (VBD did) (NP (JJ intact) (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN protein) (POS 's)) (NN C-terminus)) (VP (MD may) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (S (VP (VBG modulating) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Surprisingly)) (, ,) (NP (NP (DT the) (JJ N-terminal) (JJ third)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB alone)) (VP (VBD bound) (NP (NN _PROT1_)) (ADVP (ADVP (RBR more) (RB strongly)) (SBAR (IN than) (SINV (VBD did) (NP (JJ intact) (NN _PROT2_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN protein) (POS 's)) (NN C-terminus)) (VP (MD may) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (S (VP (VBG modulating) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Surprisingly)) (, ,) (NP (NP (DT the) (JJ N-terminal) (JJ third)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB alone)) (VP (VBD bound) (NP (NN _PROT1_)) (ADVP (ADVP (RBR more) (RB strongly)) (SBAR (IN than) (SINV (VBD did) (NP (JJ intact) (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN protein) (POS 's)) (NN C-terminus)) (VP (MD may) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (S (VP (VBG modulating) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Surprisingly)) (, ,) (NP (NP (DT the) (JJ N-terminal) (JJ third)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB alone)) (VP (VBD bound) (NP (NN _PROT_)) (ADVP (ADVP (RBR more) (RB strongly)) (SBAR (IN than) (SINV (VBD did) (NP (JJ intact) (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (DT the) (NN protein) (POS 's)) (NN C-terminus)) (VP (MD may) (VP (VB play) (NP (DT a) (NN role)) (PP (IN in) (S (VP (VBG modulating) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (, ,) (PP (IN along) (PP (IN with) (NP (JJ other) (JJ recent) (NNS findings)))) (, ,) (VP (VBP suggest) (NP (NP (DT a) (JJ novel) (NN role)) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Discrete) (NN protein) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN complex))) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT_) (JJ myeloid) (NN cell) (NN proliferation)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Discrete) (NN protein) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (JJ myeloid) (NN cell) (NN proliferation)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Discrete) (NN protein) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (JJ myeloid) (NN cell) (NN proliferation)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Discrete) (NN protein) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (JJ myeloid) (NN cell) (NN proliferation)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Discrete) (NN protein) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (JJ myeloid) (NN cell) (NN proliferation)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Discrete) (NN protein) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (JJ myeloid) (NN cell) (NN proliferation)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Hemopoietic) (NN cell) (NN proliferation)) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NP (NN non-tyrosine)) (CC and) (NP (NN tyrosine) (NNS kinases))) (SBAR (WHNP (WDT that)) (S (VP (VBP signal) (PP (IN via) (NP (NP (ADJP (ADJP (JJ uncommon)) (CC and) (ADJP (JJ common))) (NNS sets)) (PP (IN of) (NP (NP (JJ downstream) (NN effector) (NNS molecules)) (PP (VBG including) (NP (DT the) (NN _PROT1_AND_PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD evaluated) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex))) (PP (IN with) (NP (NN signaling) (NNS proteins))))) (PP (IN upon) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NP (NP (NN non-tyrosine)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN tyrosine) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (NNS receptors)) (VP (VBG leading) (PP (TO to) (NP (JJ myeloid) (NN cell) (NN proliferation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBP induce) (NP (NN _PROT_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBP induce) (NP (NN _PROT_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,)) (VP (VBP induce) (NP (NN _PROT_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBP induce) (NP (NN _PROT2_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBP induce) (NP (NN _PROT_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,)) (VP (VBP induce) (NP (NN _PROT_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBP induce) (NP (NN _PROT2_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,)) (VP (VBP induce) (NP (NN _PROT_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBP induce) (NP (NN _PROT2_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN By) (S (VP (VBG using) (NP (DT the) (ADJP (NN growth) (NN factor) (JJ dependent)) (NN M-07e) (NN cell) (NN line))))) (, ,) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (NP (NP (CC both) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS ligands)) (, ,) (ADVP (RB namely))) (: :) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,)) (VP (VBP induce) (NP (NN _PROT2_) (NN tyrosine) (NN phosphorylation)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT these) (NNS cells))) (NP (DT the) (NN adaptor) (NN protein) (NN _PROT1_)) (ADVP (RB constitutively)) (VP (VBZ binds) (NP (NP (DT a) (JJ substantial) (NN fraction)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN through) (NP (DT the) (JJ N-terminal) (NN SH3) (NN domain))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_AND_PROT2_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT2_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT2_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT2_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT2_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT1_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT1_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT2_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT1_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT_) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NNS experiments)) (VP (VBD showed) (SBAR (IN that) (S (NP (DT the) (JJ stable) (NN _PROT_) (NN complex)) (VP (VBZ interacts) (, ,) (PP (IN through) (NP (DT the) (NN _PROT_) (NN SH2) (NN domain))) (, ,) (PP (IN with) (NP (DT the) (JJ _PROT1_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (NN stimulation)) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (DT a) (NN _PROT2_) (NN complex)) (VP (VBG containing) (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (NN stimulation)) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (DT a) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (NN stimulation)) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (DT a) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (FW In) (FW vitro)) (CC and) (ADJP (FW in) (FW vivo))) (NNS experiments)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (FW In) (FW vitro)) (CC and) (ADJP (FW in) (FW vivo))) (NNS experiments)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (ADJP (FW In) (FW vitro)) (CC and) (ADJP (FW in) (FW vivo))) (NNS experiments)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (DT the) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT2_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT2_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT2_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT1_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT2_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT1_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT1_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT2_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT1_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (, ,) (PP (IN upon) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (DT the) (NN _PROT_) (NN complex)) (VP (VBZ recruits) (NP (NN _PROT1_)) (, ,) (ADVP (RB probably)) (PP (IN via) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT1_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT1_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT2_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT1_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT1_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT1_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT1_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT2_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN By) (NP (NN contrast))) (NP (NP (DT the) (NN _PROT_) (NN exchanger) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBD was) (RB not) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_))) (VP (VBP are) (ADJP (JJ present) (PP (IN in) (NP (JJ different) (NNS complexes))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (NP (PRP$ our) (NNS results)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ plays) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (NP (NP (NN coupling)) (CC both) (NP (NN tyrosine))) (CC and) (NP (NN non-tyrosine) (NN kinase) (NNS receptors))) (PP (TO to) (NP (JJ downstream) (NN effector) (NNS molecules)))))))) (CC and) (SBAR (IN that) (S (NP (JJ different) (NN signaling) (NNS molecules)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_) (NN complex))) (SBAR (WHADVP (WRB when)) (S (NP (NP (NP (NN non-tyrosine)) (CC or) (NP (NN tyrosine) (NN kinase))) (NNS receptors)) (VP (VBP are) (VP (VBN activated)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (NP (PRP$ our) (NNS results)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ plays) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (NP (NP (NN coupling)) (CC both) (NP (NN tyrosine))) (CC and) (NP (NN non-tyrosine) (NN kinase) (NNS receptors))) (PP (TO to) (NP (JJ downstream) (NN effector) (NNS molecules)))))))) (CC and) (SBAR (IN that) (S (NP (JJ different) (NN signaling) (NNS molecules)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT2_) (NN complex))) (SBAR (WHADVP (WRB when)) (S (NP (NP (NP (NN non-tyrosine)) (CC or) (NP (NN tyrosine) (NN kinase))) (NNS receptors)) (VP (VBP are) (VP (VBN activated)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (NP (PRP$ our) (NNS results)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ plays) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (NP (NP (NN coupling)) (CC both) (NP (NN tyrosine))) (CC and) (NP (NN non-tyrosine) (NN kinase) (NNS receptors))) (PP (TO to) (NP (JJ downstream) (NN effector) (NNS molecules)))))))) (CC and) (SBAR (IN that) (S (NP (JJ different) (NN signaling) (NNS molecules)) (VP (VBP interact) (PP (IN with) (NP (NN _PROT1_AND_PROT2_) (NN complex))) (SBAR (WHADVP (WRB when)) (S (NP (NP (NP (NN non-tyrosine)) (CC or) (NP (NN tyrosine) (NN kinase))) (NNS receptors)) (VP (VBP are) (VP (VBN activated)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT_) (NN Identification)) (PP (IN of) (NP (NP (CD two) (NN ligand) (NN binding) (NNS domains)) (PP (IN in) (NP (JJ soluble) (NN _PROT_))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (CC and) (NP (JJ chemical) (NN cross-linking))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN Identification)) (PP (IN of) (NP (NP (CD two) (NN ligand) (NN binding) (NNS domains)) (PP (IN in) (NP (JJ soluble) (NN _PROT_))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (CC and) (NP (JJ chemical) (NN cross-linking))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN Identification)) (PP (IN of) (NP (NP (CD two) (NN ligand) (NN binding) (NNS domains)) (PP (IN in) (NP (JJ soluble) (NN _PROT2_))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (CC and) (NP (JJ chemical) (NN cross-linking))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_) (NN Identification)) (PP (IN of) (NP (NP (CD two) (NN ligand) (NN binding) (NNS domains)) (PP (IN in) (NP (JJ soluble) (NN _PROT_))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (CC and) (NP (JJ chemical) (NN cross-linking))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT_) (NN Identification)) (PP (IN of) (NP (NP (CD two) (NN ligand) (NN binding) (NNS domains)) (PP (IN in) (NP (JJ soluble) (NN _PROT2_))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (CC and) (NP (JJ chemical) (NN cross-linking))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN Identification)) (PP (IN of) (NP (NP (CD two) (NN ligand) (NN binding) (NNS domains)) (PP (IN in) (NP (JJ soluble) (NN _PROT2_))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (CC and) (NP (JJ chemical) (NN cross-linking))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (VP (VBN expressed) (PP (IN in) (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells))))))) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB highly) (VBN glycosylated)) (NN protein)) (, ,) (VP (VBG possessing) (NP (NN binding) (NN ability)) (PP (IN for) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT1_) (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells))))))) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB highly) (VBN glycosylated)) (NN protein)) (, ,) (VP (VBG possessing) (NP (NN binding) (NN ability)) (PP (IN for) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT1_) (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells))))))) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB highly) (VBN glycosylated)) (NN protein)) (, ,) (VP (VBG possessing) (NP (NN binding) (NN ability)) (PP (IN for) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells))))))) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB highly) (VBN glycosylated)) (NN protein)) (, ,) (VP (VBG possessing) (NP (NN binding) (NN ability)) (PP (IN for) (NP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells))))))) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB highly) (VBN glycosylated)) (NN protein)) (, ,) (VP (VBG possessing) (NP (NN binding) (NN ability)) (PP (IN for) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (VP (VBN expressed) (PP (IN in) (NP (JJ Chinese) (NN hamster) (NN ovary) (NNS cells))))))) (VP (VBZ is) (NP (NP (DT a) (ADJP (RB highly) (VBN glycosylated)) (NN protein)) (, ,) (VP (VBG possessing) (NP (NN binding) (NN ability)) (PP (IN for) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Two) (JJ distinct) (NN ligand) (NN binding) (NNS domains)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ proteolytic) (NNS digests)) (PP (IN of) (NP (DT the) (NN receptor))))) (PP (IN by) (NP (NP (NN affinity) (NN separation)) (PP (IN on) (NP (JJ immobilized) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS results)) (, ,) (VP (VBN obtained) (PP (IN from) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ experimental) (NNS techniques)))))) (, ,)) (VP (VBP highlight) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))) (PP (IN in) (NP (VBG binding) (NNS _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT These) (NNS results)) (, ,) (VP (VBN obtained) (PP (IN from) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ experimental) (NNS techniques)))))) (, ,)) (VP (VBP highlight) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT_))))))) (PP (IN in) (NP (VBG binding) (NNS _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT These) (NNS results)) (, ,) (VP (VBN obtained) (PP (IN from) (NP (NP (DT a) (NN variety)) (PP (IN of) (NP (JJ experimental) (NNS techniques)))))) (, ,)) (VP (VBP highlight) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (NP (CD two) (JJ distinct) (NNS regions)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))))) (PP (IN in) (NP (VBG binding) (NNS _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT2_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT2_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN oTP-1)) (VP (VP (MD may) (VP (VB prevent) (NP (NN luteolysis)) (PP (IN by) (S (VP (VBG inhibiting) (NP (NP (NN development)) (PP (IN of) (NP (NP (JJ endometrial) (NN responsiveness)) (PP (TO to) (NP (NN _PROT1_))))))))))) (CC and) (, ,) (ADVP (RB therefore)) (, ,) (VP (VB reduce) (NP (NP (JJ _PROT2_) (NN synthesis)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN PGF2) (NN alpha)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN oTP-1)) (VP (VP (MD may) (VP (VB prevent) (NP (NN luteolysis)) (PP (IN by) (S (VP (VBG inhibiting) (NP (NP (NN development)) (PP (IN of) (NP (NP (JJ endometrial) (NN responsiveness)) (PP (TO to) (NP (NN _PROT1_))))))))))) (CC and) (, ,) (ADVP (RB therefore)) (, ,) (VP (VB reduce) (NP (NP (JJ _PROT_) (NN synthesis)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN PGF2) (NN alpha)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN oTP-1)) (VP (VP (MD may) (VP (VB prevent) (NP (NN luteolysis)) (PP (IN by) (S (VP (VBG inhibiting) (NP (NP (NN development)) (PP (IN of) (NP (NP (JJ endometrial) (NN responsiveness)) (PP (TO to) (NP (NN _PROT_))))))))))) (CC and) (, ,) (ADVP (RB therefore)) (, ,) (VP (VB reduce) (NP (NP (JJ _PROT1_) (NN synthesis)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN PGF2) (NN alpha)))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN SGR)) (CC and) (NP (NN RGR)))) (ADVP (RB also)) (VP (VBD had) (NP (JJ different) (JJ endocrine) (NNS profiles)) (PP (PP (IN with)) (, ,) (PP (IN for) (NP (NN example)))) (, ,) (ADVP (RB twice)) (PP (IN as) (NP (NP (JJ high) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.01)) (-RRB- -RRB-)))))) (CC and) (S (NP (NP (NP (NN _PROT2_) (NNS levels)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.01)) (-RRB- -RRB-))) (PP (IN in) (NP (NN RGR)))) (VP (VBN compared) (PP (TO to) (NP (DT the) (NN SGR))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT This) (NN action)) (PP (IN of) (NP (NN _PROT1_) (CD 25-35)))) (VP (VBZ is) (RB not) (VP (VBN altered) (PP (IN by) (NP (NP (NN pretreatment)) (PP (PP (IN with) (NP (NP (DT the) (NN calcium) (NN channel) (NNS blockers)) (NP (NP (NN nifedipine)) (CC or) (NP (NN cobalt))))) (, ,) (PP (IN with) (NP (NP (NP (DT the) (NN depleter)) (PP (IN of) (NP (JJ intracellular) (NN calcium) (NNS stores)))) (NP (JJ cyclopiazonic) (NN acid)))) (, ,) (CC or) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN inhibitor) (NN neomycin)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP support) (NP (DT the) (NN concept) (SBAR (IN that) (S (NP (NP (DT the) (JJ mitochondrial) (NN metabolism)) (PP (IN of) (NP (JJ nutrient) (NNS molecules)))) (VP (VBZ is) (NP (NP (DT an) (NN event)) (ADJP (JJ sufficient) (S (VP (VP (TO to) (ADVP (RB acutely)) (VP (VB augment) (NP (NP (NN _PROT1_) (NN release)) (PP (IN from) (NP (DT the) (NN beta) (NN cell)))))) (, ,) (VP (TO to) (VP (VB increase) (NP (NN _PROT2_) (JJ _PROT2_) (NN phosphoinositide) (NN hydrolysis)))) (, ,) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (JJ time-dependent) (NN potentiation)) (PP (IN of) (NP (NN _PROT_) (NN secretion))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP support) (NP (DT the) (NN concept) (SBAR (IN that) (S (NP (NP (DT the) (JJ mitochondrial) (NN metabolism)) (PP (IN of) (NP (JJ nutrient) (NNS molecules)))) (VP (VBZ is) (NP (NP (DT an) (NN event)) (ADJP (JJ sufficient) (S (VP (VP (TO to) (ADVP (RB acutely)) (VP (VB augment) (NP (NP (NN _PROT1_) (NN release)) (PP (IN from) (NP (DT the) (NN beta) (NN cell)))))) (, ,) (VP (TO to) (VP (VB increase) (NP (NN _PROT_) (JJ _PROT_) (NN phosphoinositide) (NN hydrolysis)))) (, ,) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (JJ time-dependent) (NN potentiation)) (PP (IN of) (NP (NN _PROT2_) (NN secretion))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP support) (NP (DT the) (NN concept) (SBAR (IN that) (S (NP (NP (DT the) (JJ mitochondrial) (NN metabolism)) (PP (IN of) (NP (JJ nutrient) (NNS molecules)))) (VP (VBZ is) (NP (NP (DT an) (NN event)) (ADJP (JJ sufficient) (S (VP (VP (TO to) (ADVP (RB acutely)) (VP (VB augment) (NP (NP (NN _PROT_) (NN release)) (PP (IN from) (NP (DT the) (NN beta) (NN cell)))))) (, ,) (VP (TO to) (VP (VB increase) (NP (NN _PROT1_) (JJ _PROT1_) (NN phosphoinositide) (NN hydrolysis)))) (, ,) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (JJ time-dependent) (NN potentiation)) (PP (IN of) (NP (NN _PROT2_) (NN secretion))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Signal) (NN transduction)) (PP (IN in) (NP (JJ pancreatic) (NNS beta-cells)))) (: :) (NP (NP (NN Regulation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))) (PP (IN by) (NP (NP (NN information) (NN flow)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN kinase) (NN C) (NN pathway))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (JJ glucose-induced) (NN _PROT1_) (NN secretion)))) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN upon) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN information) (NN flow))) (PP (IN in) (NP (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NN /protein) (NN kinase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN signal) (NN transduction) (NN system))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NN rat) (NN islet)) (VP (VBP are) (VP (VBN cultured) (PP (IN for) (NP (JJ short) (NNS periods))))))) (, ,) (NP (NP (DT the) (NP (NN content)) (CC and) (NP (NN activation))) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NP (NN response)) (PP (TO to) (NP (NN glucose) (NNS decreases)))) (CC and) (NP (NP (DT this) (JJ biochemical) (NN defect)) (PP (IN in) (NP (NN signal) (NN transduction))))))) (VP (VBZ is) (VP (VBN paralleled) (PP (IN by) (NP (NP (JJ significant) (NNS reductions)) (PP (IN in) (NP (JJ glucose-induced) (NN _PROT2_) (NN secretion))))))))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Biphasic) (NN _PROT1_) (NN secretion)) (VP (MD can) (VP (VB be) (VP (VBN evoked))))) (CC and) (S (NP (JJ time-dependent) (NN potentiation)) (VP (MD can) (VP (VB be) (VP (VBN induced) (PP (IN in) (NP (NN mouse) (NNS islets))) (PP (IN by) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT an) (NN agonist)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (NP (DT an) (NN isozyme)) (PP (IN of) (NP (NN _PROT2_))) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN activated) (PP (IN by) (NP (NN glucose)))))))))))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN taken) (PP (IN in) (NP (PRP$ their) (NN entirety)))))) (, ,) (S (NP (DT the) (JJ experimental) (NN evidence)) (VP (VBZ suggests) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (NP (NP (DT an) (JJ essential) (NN component)) (PP (IN in) (NP (NP (DT the) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (NN _PROT2_) (NN secretion))))))))) (CC and) (SBAR (IN that) (S (NP (NP (VBN disordered) (NN activation)) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ culminates) (PP (IN in) (NP (VBN disordered) (NN _PROT_) (NN release))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN taken) (PP (IN in) (NP (PRP$ their) (NN entirety)))))) (, ,) (S (NP (DT the) (JJ experimental) (NN evidence)) (VP (VBZ suggests) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (NP (NP (DT an) (JJ essential) (NN component)) (PP (IN in) (NP (NP (DT the) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (NN _PROT_) (NN secretion))))))))) (CC and) (SBAR (IN that) (S (NP (NP (VBN disordered) (NN activation)) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ culminates) (PP (IN in) (NP (VBN disordered) (NN _PROT2_) (NN release))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN taken) (PP (IN in) (NP (PRP$ their) (NN entirety)))))) (, ,) (S (NP (DT the) (JJ experimental) (NN evidence)) (VP (VBZ suggests) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (NP (NP (DT an) (JJ essential) (NN component)) (PP (IN in) (NP (NP (DT the) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))))))))) (CC and) (SBAR (IN that) (S (NP (NP (VBN disordered) (NN activation)) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ culminates) (PP (IN in) (NP (VBN disordered) (NN _PROT2_) (NN release))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Cellular) (NN preincubation)) (PP (IN with) (NP (NP (NP (ADJP (CD 200) (NN microg/ml)) (NNS antibodies)) (PP (IN against) (NP (NP (DT the) (NN inositolphosphoglycan) (-LRB- -LRB-) (NN IPG) (-RRB- -RRB-) (NN moiety)) (PP (IN of) (NP (DT the) (NN GPI-anchor))))) (PRN (-LRB- -LRB-) (NP (NP (NN Ab)) (PRN (-LRB- -LRB-) (NP (NN IPG)) (-RRB- -RRB-))) (-RRB- -RRB-)) (, ,)) (CC or) (NP (NP (NN depletion)) (PP (IN in) (NP (JJ GPI-anchored) (NNS proteins))) (PP (IN by) (NP (NP (JJ cellular) (NN pretreatment)) (PP (IN with) (NP (NP (ADJP (CD 0.5) (NN U/ml)) (NN _PROT1_)) (, ,) (NP (NP (CD 1) (NN mM) (NN _PROT2_)) (CC and) (NP (CD 2) (NN HU/ml) (JJ streptolysin-O))) (, ,) (CC or) (NP (NP (NN depletion)) (PP (IN in) (NP (NN membrane) (NN cholesterol) (NN content))) (PP (IN by) (NP (NP (NP (NN filipin)) (PRN (-LRB- -LRB-) (NP (CD 5) (NN microg/ml)) (-RRB- -RRB-))) (, ,) (NP (NP (NN digitonin)) (PRN (-LRB- -LRB-) (NP (CD 5) (NN microg/ml)) (-RRB- -RRB-))) (CC and) (NP (NP (NN cholesterol) (NN oxidase)) (PRN (-LRB- -LRB-) (NP (CD 0.5) (NN U/ml)) (-RRB- -RRB-)))))))))))))) (VP (VBZ decreases) (NP (DT the) (NN HDL3-signal)) (, ,) (S (VP (VBG suggesting) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (DT a) (JJ lipolytic) (NN cleavage)) (PP (IN of) (NP (JJ GPI-anchored) (NNS proteins))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT1_) (NN beta) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 25-35)) (-RRB- -RRB-))) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (NN LA-N-2) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT This) (NN _PROT1_) (NN _PROT1_) (NN stimulation)) (PP (IN by) (NP (JJ _PROT2_) (NN beta) (NN protein)))) (VP (VBD appeared) (S (VP (TO to) (VP (VB be) (NP (NN pertussis) (NN toxin) (JJ sensitive)))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (ADJP (JJ possible)) (SBAR (IN that) (S (NP (NP (DT this) (NN _PROT1_) (NN _PROT1_) (NN stimulation)) (PP (IN by) (NP (JJ _PROT2_) (NN beta) (NN protein)))) (VP (VBZ is) (NP (DT a) (JJ receptor-mediated) (NN process)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBD was) (ADJP (JJ absent) (PP (IN from) (NP (NP (NN LA-N-2) (NNS cells)) (VP (ADVP (RB previously)) (VBN treated) (PP (IN with) (NP (NP (NN norepinephrine)) (, ,) (NP (NP (JJ trans-1-amino-1,3-cyclopentanedicarboxylic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN t-ACPD)) (-RRB- -RRB-))) (, ,) (NP (NN bombesin)) (, ,) (CC or) (NP (NN _PROT_) (NN beta) (NN peptide))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (ADJP (JJ absent) (PP (IN from) (NP (NP (NN LA-N-2) (NNS cells)) (VP (ADVP (RB previously)) (VBN treated) (PP (IN with) (NP (NP (NN norepinephrine)) (, ,) (NP (NP (JJ trans-1-amino-1,3-cyclopentanedicarboxylic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN t-ACPD)) (-RRB- -RRB-))) (, ,) (NP (NN bombesin)) (, ,) (CC or) (NP (NN _PROT2_) (NN beta) (NN peptide))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (ADJP (JJ absent) (PP (IN from) (NP (NP (NN LA-N-2) (NNS cells)) (VP (ADVP (RB previously)) (VBN treated) (PP (IN with) (NP (NP (NN norepinephrine)) (, ,) (NP (NP (JJ trans-1-amino-1,3-cyclopentanedicarboxylic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN t-ACPD)) (-RRB- -RRB-))) (, ,) (NP (NN bombesin)) (, ,) (CC or) (NP (NN _PROT2_) (NN beta) (NN peptide))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (VP (VBN suggested) (SBAR (IN that) (S (NP (NP (DT this) (VBN observed) (NN _PROT1_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (MD may) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (JJ elevated) (NN quantity)) (PP (IN of) (NP (NN inositol))) (VP (VBN seen) (PP (IN in) (NP (NP (DT the) (NNS brains)) (PP (IN of) (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (NNS patients))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (DT the) (NN glycosyl) (JJ phosphatidylinositol-anchored) (NN membrane) (NN dipeptidase))) (PP (IN from) (NP (NN 3T3-L1) (NNS adipocytes)))) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ hydrophilic) (NN form)) (PP (IN of) (NP (NP (NN MDP)) (VP (VBN released) (PP (IN from) (NP (NP (DT the) (NNS cells)) (PP (IN on) (NP (NP (NN stimulation)) (PP (IN with) (NP (NN _PROT1_))))))))))) (VP (VBD was) (VP (VBN recognized) (PP (IN by) (NP (NP (NNS antibodies)) (PP (IN against) (NP (NP (DT the) (NN inositol) (JJ 1,2-cyclic) (NN monophosphate)) (VP (VBG cross-reacting) (NP (NN determinant))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD had) (VP (VBN been) (VP (VBN generated) (PP (IN by) (NP (NP (NN cleavage)) (PP (IN of) (NP (PRP$ its) (NN GPI) (NN anchor))))) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN After) (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN activity)) (VP (VBD was) (ADVP (RB functionally)) (VP (VBN depleted) (PP (IN by) (S (VP (VBG treating) (NP (NNS cells)) (PP (IN with) (NP (NP (NN phorbol) (NN 12-myristate) (NN 13-acetate)) (PP (IN for) (NP (CD 24) (NNS hours)))))))))))) (, ,) (NP (PRP _PROT2_)) (VP (VBD did) (RB not) (VP (VB augment) (NP (JJ IL-1beta-induced) (NN NO) (NN production)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN effect)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD was) (ADVP (RB also)) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN inhibitor) (NN calphostin) (NN C))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NNS _PROT1_)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activity)) (PP (IN in) (NP (JJ cardiac) (NNS myocytes)))))) (, ,) (CC and) (S (NP (PRP$ its) (NN effect)) (VP (VBD was) (ADVP (RB significantly)) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN calphostin) (NN C)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (SBAR (IN that) (S (NP (DT the) (NN heart)) (VP (MD may) (VP (VB be) (NP (NP (DT a) (NN target) (NN organ)) (PP (IN for) (NP (NN _PROT1_)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ modulates) (NP (NP (JJ IL-1beta-induced) (NN iNOS) (NN expression)) (PP (IN in) (NP (NNS myocytes)))) (PP (IN through) (NP (NP (DT the) (NN V1a) (NN receptor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN mediated) (ADVP (ADVP (IN at) (JJS least)) (RB partially)) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (SBAR (IN that) (S (NP (DT the) (NN heart)) (VP (MD may) (VP (VB be) (NP (NP (DT a) (NN target) (NN organ)) (PP (IN for) (NP (NN _PROT1_)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ modulates) (NP (NP (JJ IL-1beta-induced) (NN iNOS) (NN expression)) (PP (IN in) (NP (NNS myocytes)))) (PP (IN through) (NP (NP (DT the) (NN V1a) (NN receptor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN mediated) (ADVP (ADVP (IN at) (JJS least)) (RB partially)) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (SBAR (IN that) (S (NP (DT the) (NN heart)) (VP (MD may) (VP (VB be) (NP (NP (DT a) (NN target) (NN organ)) (PP (IN for) (NP (NN _PROT_)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ modulates) (NP (NP (JJ IL-1beta-induced) (NN iNOS) (NN expression)) (PP (IN in) (NP (NNS myocytes)))) (PP (IN through) (NP (NP (DT the) (NN V1a) (NN receptor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN mediated) (ADVP (ADVP (IN at) (JJS least)) (RB partially)) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (ADVP (RB recently)) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-LRB- -LRB-) (NN PKC) (-RRB- -RRB-) (JJ -dependent)) (NN increase)) (PP (IN in) (NP (NP (NN ACTH) (NN release)) (CC and) (NP (NN biosynthesis)))) (PP (IN in) (NP (NP (NN ovine) (JJ anterior) (NN pituitary)) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT these) (NNS cells))) (, ,) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ causes) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN from) (NP (DT the) (NN cytosol))) (PP (TO to) (NP (NP (DT the) (NN cell) (NN membrane)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (CD 5) (NN min)))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (JJ intracellular) (NNS events)) (ADJP (JJ distal) (PP (TO to) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (NN activation)) (SBAR (WHNP (WDT that)) (S (VP (VBP underlie) (NP (NN ACTH) (NN secretion))))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADVP (RB well)) (VP (VBN characterized) (PP (TO to) (NP (NN date)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT these) (NNS cells))) (, ,) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ causes) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN from) (NP (DT the) (NN cytosol))) (PP (TO to) (NP (NP (DT the) (NN cell) (NN membrane)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (CD 5) (NN min)))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (JJ intracellular) (NNS events)) (ADJP (JJ distal) (PP (TO to) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)) (SBAR (WHNP (WDT that)) (S (VP (VBP underlie) (NP (NN ACTH) (NN secretion))))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADVP (RB well)) (VP (VBN characterized) (PP (TO to) (NP (NN date)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT these) (NNS cells))) (, ,) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ causes) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN from) (NP (DT the) (NN cytosol))) (PP (TO to) (NP (NP (DT the) (NN cell) (NN membrane)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (CD 5) (NN min)))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (JJ intracellular) (NNS events)) (ADJP (JJ distal) (PP (TO to) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)) (SBAR (WHNP (WDT that)) (S (VP (VBP underlie) (NP (NN ACTH) (NN secretion))))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADVP (RB well)) (VP (VBN characterized) (PP (TO to) (NP (NN date)))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Since) (S (NP (DT the) (NN MARCKS) (NN protein)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN neurosecretion)))))) (CC and) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NNS synaptosomes)))))))) (, ,) (S (S (NP (NNS studies)) (VP (VBD were) (VP (VBN carried) (PRT (RP out)) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NN _PROT2_)) (VP (MD might) (VP (VB cause) (NP (NN MARCKS) (NN phosphorylation)) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))))))))))) (, ,) (CC and) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (DT this) (NN phenomenon)) (VP (MD might) (VP (VB be) (VP (ADVP (RB temporally)) (VBN correlated) (PP (IN with) (NP (NP (NN _PROT_) (NN translocation)) (CC and) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN ACTH))))))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Since) (S (NP (DT the) (NN MARCKS) (NN protein)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN neurosecretion)))))) (CC and) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NNS synaptosomes)))))))) (, ,) (S (S (NP (NNS studies)) (VP (VBD were) (VP (VBN carried) (PRT (RP out)) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (MD might) (VP (VB cause) (NP (NN MARCKS) (NN phosphorylation)) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))))))))))) (, ,) (CC and) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (DT this) (NN phenomenon)) (VP (MD might) (VP (VB be) (VP (ADVP (RB temporally)) (VBN correlated) (PP (IN with) (NP (NP (NN _PROT2_) (NN translocation)) (CC and) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN ACTH))))))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Since) (S (NP (DT the) (NN MARCKS) (NN protein)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN neurosecretion)))))) (CC and) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NNS synaptosomes)))))))) (, ,) (S (S (NP (NNS studies)) (VP (VBD were) (VP (VBN carried) (PRT (RP out)) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (MD might) (VP (VB cause) (NP (NN MARCKS) (NN phosphorylation)) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))))))))))) (, ,) (CC and) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (DT this) (NN phenomenon)) (VP (MD might) (VP (VB be) (VP (ADVP (RB temporally)) (VBN correlated) (PP (IN with) (NP (NP (NN _PROT2_) (NN translocation)) (CC and) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN ACTH))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT2_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT2_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT2_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT2_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT1_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT2_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS observations)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN bradykinin)) (, ,) (PP (IN like) (NP (NN _PROT1_))) (, ,) (VP (VBZ activates) (NP (NP (NN phospholipase) (NN C)) (SBAR (WHNP (WDT which)) (S (VP (VBZ generates) (NP (NN _PROT2_)) (PP (IN with) (NP (NP (DT a) (JJ subsequent) (NN release)) (PP (IN of) (NP (NN Ca2+))) (PP (IN from) (NP (NP (JJ intracellular) (NNS stores)) (VP (VBN followed) (PP (IN by) (NP (JJ store-operated) (NN Ca2+) (NN influx)))))))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (VP (VBD reversed) (NP (NN _PROT2_) (NN inhibition)))) (, ,) (IN whereas) (S (NP (NN _PROT_) (NN activator)) (VP (VBD inhibited) (NP (NN nitrite) (NN production)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (VP (VBD reversed) (NP (NN _PROT_) (NN inhibition)))) (, ,) (IN whereas) (S (NP (NN _PROT2_) (NN activator)) (VP (VBD inhibited) (NP (NN nitrite) (NN production)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (VP (VBD reversed) (NP (NN _PROT1_) (NN inhibition)))) (, ,) (IN whereas) (S (NP (NN _PROT2_) (NN activator)) (VP (VBD inhibited) (NP (NN nitrite) (NN production)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ inhibitory) (NN action)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ involves) (NP (CC both) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN iNOS) (NN mRNA))))) (PP (IN in) (NP (VBN cultured) (NN rat) (NN GMC)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT An) (NN inhibitor)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NP (NN Ro31-8220)) (PRN (-LRB- -LRB-) (NP (CD 10) (NN microM)) (-RRB- -RRB-))) (, ,)) (VP (VBD abolished) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PDBu))) (S (VP (TO to) (VP (VB decrease) (NP (NP (NP (NN [Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-) (-RRB- -RSB-))) (PRN (-LRB- -LRB-) (NP (NN i)) (-RRB- -RRB-))))))) (, ,) (PP (IN without) (S (VP (VBG affecting) (NP (NP (DT the) (NN response)) (PP (TO to) (NP (NP (ADJP (ADJP (JJ maximal)) (CC or) (ADJP (JJ submaximal))) (NNS concentrations)) (PP (IN of) (NP (NN _PROT2_)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN etiology)) (PP (IN for) (NP (NP (NN diabetes) (NN mellitus)) (PP (IN in) (NP (NNS PWS)))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (TO to) (NP (NP (DT the) (JJ morbid) (NN obesity)) (CC and) (NP (JJ consequent) (NN _PROT1_) (NN resistance))))) (, ,) (SBAR (IN because) (S (NP (NP (NP (DT a) (NN decrease)) (PP (IN of) (NP (JJ _PROT2_) (NNS neurons)))) (CC and) (NP (NP (NN leptin) (NN resistance)) (PP (IN in) (NP (NNS PWS))))) (VP (MD may) (VP (VB cause) (NP (NN hyperphagia)) (, ,) (S (VP (VBG inducing) (NP (NN obesity)))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (VP (VBZ stimulates) (NP (NP (NP (NN heat) (NN shock) (NN protein) (CD 27)) (PRN (-LRB- -LRB-) (NP (NN HSP27)) (-RRB- -RRB-))) (NN induction)) (PP (IN through) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)) (PP (IN in) (NP (JJ aortic) (JJ smooth) (NN muscle) (NN A10) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Calphostin) (NN C)) (CC and) (NP (NN ET-18-OCH) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-))) (, ,) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (, ,)) (VP (VBD reduced) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN p38) (NN MAP) (NN kinase))) (PP (IN by) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Ca2+) (NN signalling)) (PP (IN in) (NP (NN rat) (JJ vascular) (NN smooth) (NN muscle) (NNS cells)))) (: :) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (IN at) (NP (NP (JJ physiological) (NN vasoconstrictor) (NNS concentrations)) (PP (IN of) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activator) (NN 4beta-phorbol) (NN 12-myristate) (NN 13-acetate)) (PRN (-LRB- -LRB-) (NP (NP (NN PMA)) (, ,) (NP (CD 100) (NN pM) (TO to) (CD 200) (NN nM))) (-RRB- -RRB-)) (, ,)) (ADVP (RB also)) (VP (VBD stimulated) (NP (NN Ca2+) (NN spiking)))) (CC and) (S (NP (DT this) (NN effect)) (VP (VBD was) (ADJP (JJ additive)) (PP (IN with) (NP (NP (DT a) (JJ submaximal) (NN concentration)) (PP (IN of) (NP (NN _PROT2_))))) (PRN (-LRB- -LRB-) (NP (CD 50) (NN pM)) (-RRB- -RRB-)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NNS _PROT1_)) (NP (NP (NP (NN Ro-31-8220)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-))) (CC and) (NP (NP (NN calphostin) (NN C)) (PRN (-LRB- -LRB-) (NP (CD 250) (NN nM)) (-RRB- -RRB-))))) (ADVP (RB completely)) (VP (VBD blocked) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN Ca2+) (NN spiking))) (PP (IN by) (NP (CC either) (NP (NN PMA)) (CC or) (NP (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Time-dependent) (NN redistribution)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN -delta)) (CC and) (NP (NN -epsilon))) (NNS isoforms))) (PP (IN between) (NP (NP (DT the) (NP (NN membrane)) (CC and) (NP (JJ cytosolic) (NNS fractions))) (VP (VBD occurred) (PP (IN in) (NN response) (TO to) (NP (ADJP (CD 100) (NN pM)) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN for) (NP (CD 24) (NN h))) (PP (IN with) (NP (ADJP (CD 1) (NN microM)) (NN PMA)))) (VP (VP (VBD downregulated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN -delta))) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,))))) (CC and) (VP (VBD prevented) (NP (NP (DT the) (JJ Ca2+-spiking) (NNS responses)) (PP (TO to) (NP (CC either) (NP (ADJP (CD 1) (NN nM)) (NN PMA)) (CC or) (NP (ADJP (CD 100) (NN pM)) (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN for) (NP (CD 24) (NN h))) (PP (IN with) (NP (ADJP (CD 1) (NN microM)) (NN PMA)))) (VP (VP (VBD downregulated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN -delta))) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,))))) (CC and) (VP (VBD prevented) (NP (NP (DT the) (JJ Ca2+-spiking) (NNS responses)) (PP (TO to) (NP (CC either) (NP (ADJP (CD 1) (NN nM)) (NN PMA)) (CC or) (NP (ADJP (CD 100) (NN pM)) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN for) (NP (CD 24) (NN h))) (PP (IN with) (NP (ADJP (CD 1) (NN microM)) (NN PMA)))) (VP (VP (VBD downregulated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN -delta))) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)) (, ,))))) (CC and) (VP (VBD prevented) (NP (NP (DT the) (JJ Ca2+-spiking) (NNS responses)) (PP (TO to) (NP (CC either) (NP (ADJP (CD 1) (NN nM)) (NN PMA)) (CC or) (NP (ADJP (CD 100) (NN pM)) (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activation)) (VP (VBZ is) (NP (NP (DT a) (JJ necessary) (NN step)) (PP (IN in) (NP (NP (DT the) (NN signal) (NN transduction) (NN pathway)) (VP (VBG linking) (NP (NP (JJ low) (NNS concentrations)) (PP (IN of) (NP (NN _PROT2_)))) (PP (TO to) (NP (NP (NN Ca2+) (NN spiking)) (PP (IN in) (NP (NN A7r5) (NNS cells))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NP (NP (JJ fatty) (NN acid) (NN translocase/CD36)) (, ,) (NP (NN peroxisome) (JJ proliferator-activated) (NN receptor-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NNS _PROT2_) (NP (CD _PROT2_) (CC and) (CD _PROT_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor-alpha))) (NN gene) (NN expression))) (PP (IN in) (NP (JJ human) (NN subcutaneous) (NN fat))) (PP (IN by) (NP (NN lipid) (NN infusion)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NP (NP (JJ fatty) (NN acid) (NN translocase/CD36)) (, ,) (NP (NN peroxisome) (JJ proliferator-activated) (NN receptor-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NNS _PROT_) (NP (CD _PROT_) (CC and) (CD _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor-alpha))) (NN gene) (NN expression))) (PP (IN in) (NP (JJ human) (NN subcutaneous) (NN fat))) (PP (IN by) (NP (NN lipid) (NN infusion)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NP (NP (JJ fatty) (NN acid) (NN translocase/CD36)) (, ,) (NP (NN peroxisome) (JJ proliferator-activated) (NN receptor-gamma2)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NNS _PROT1_) (NP (CD _PROT1_) (CC and) (CD _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor-alpha))) (NN gene) (NN expression))) (PP (IN in) (NP (JJ human) (NN subcutaneous) (NN fat))) (PP (IN by) (NP (NN lipid) (NN infusion)))))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ reverse) (NN transcriptase-polymerase) (NN chain) (NN reaction)) (NN analysis)))) (, ,) (NP (NP (DT the) (NN mRNA) (NN expression)) (PP (IN of) (NP (NP (JJ fatty) (NN acid) (NN translocase) (PRN (-LRB- -LRB-) (NP (NN FAT)) (-RRB- -RRB-)) (CD /CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor) (-LRB- -LRB-) (NN TNF) (-RRB- -RRB-) (NN -alpha))))) (VP (VBD was) (VP (VBN investigated) (PP (IN in) (NP (JJ gluteal) (JJ subcutaneous) (JJ fat) (NNS biopsies))) (PP (IN before) (CC and) (PP (IN after) (NP (NP (CD 5) (NN h) (NNS infusions)) (PP (IN of) (NP (NP (NN saline)) (CC or) (NP (NP (NP (NN Intralipid)) (PRN (-LRB- -LRB-) (NP (NP (NNP Pharmacia)) (CC and) (NP (NNP Upjohn) (, ,) (NNP Milan) (, ,) (NNP Italy))) (-RRB- -RRB-))) (CC plus) (NP (NN heparin))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB modify) (NP (NN insulinemia))))))))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ reverse) (NN transcriptase-polymerase) (NN chain) (NN reaction)) (NN analysis)))) (, ,) (NP (NP (DT the) (NN mRNA) (NN expression)) (PP (IN of) (NP (NP (JJ fatty) (NN acid) (NN translocase) (PRN (-LRB- -LRB-) (NP (NN FAT)) (-RRB- -RRB-)) (CD /CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor) (-LRB- -LRB-) (NN TNF) (-RRB- -RRB-) (NN -alpha))))) (VP (VBD was) (VP (VBN investigated) (PP (IN in) (NP (JJ gluteal) (JJ subcutaneous) (JJ fat) (NNS biopsies))) (PP (IN before) (CC and) (PP (IN after) (NP (NP (CD 5) (NN h) (NNS infusions)) (PP (IN of) (NP (NP (NN saline)) (CC or) (NP (NP (NP (NN Intralipid)) (PRN (-LRB- -LRB-) (NP (NP (NNP Pharmacia)) (CC and) (NP (NNP Upjohn) (, ,) (NNP Milan) (, ,) (NNP Italy))) (-RRB- -RRB-))) (CC plus) (NP (NN heparin))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB modify) (NP (NN insulinemia))))))))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ reverse) (NN transcriptase-polymerase) (NN chain) (NN reaction)) (NN analysis)))) (, ,) (NP (NP (DT the) (NN mRNA) (NN expression)) (PP (IN of) (NP (NP (JJ fatty) (NN acid) (NN translocase) (PRN (-LRB- -LRB-) (NP (NN FAT)) (-RRB- -RRB-)) (CD /CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor) (-LRB- -LRB-) (NN TNF) (-RRB- -RRB-) (NN -alpha))))) (VP (VBD was) (VP (VBN investigated) (PP (IN in) (NP (JJ gluteal) (JJ subcutaneous) (JJ fat) (NNS biopsies))) (PP (IN before) (CC and) (PP (IN after) (NP (NP (CD 5) (NN h) (NNS infusions)) (PP (IN of) (NP (NP (NN saline)) (CC or) (NP (NP (NP (NN Intralipid)) (PRN (-LRB- -LRB-) (NP (NP (NNP Pharmacia)) (CC and) (NP (NNP Upjohn) (, ,) (NNP Milan) (, ,) (NNP Italy))) (-RRB- -RRB-))) (CC plus) (NP (NN heparin))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB modify) (NP (NN insulinemia))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Marked) (NNS increases)) (PP (IN in) (NP (NP (NP (NN FAT/CD36)) (PRN (-LRB- -LRB-) (NP (CD 724+/-18) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN PPAR-gamma2)) (PRN (-LRB- -LRB-) (NP (CD 200+/-8) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 110+/-13) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 120+/-7) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 80+/-5) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN TNF-alpha) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (CD 130+/-12) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (NN pretreatment) (NNS levels)))))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD was) (NP (DT no) (NN change)) (PP (IN after) (NP (NN saline) (NN infusion))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Marked) (NNS increases)) (PP (IN in) (NP (NP (NP (NN FAT/CD36)) (PRN (-LRB- -LRB-) (NP (CD 724+/-18) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN PPAR-gamma2)) (PRN (-LRB- -LRB-) (NP (CD 200+/-8) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 110+/-13) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 120+/-7) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 80+/-5) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN TNF-alpha) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (CD 130+/-12) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (NN pretreatment) (NNS levels)))))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD was) (NP (DT no) (NN change)) (PP (IN after) (NP (NN saline) (NN infusion))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Marked) (NNS increases)) (PP (IN in) (NP (NP (NP (NN FAT/CD36)) (PRN (-LRB- -LRB-) (NP (CD 724+/-18) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN PPAR-gamma2)) (PRN (-LRB- -LRB-) (NP (CD 200+/-8) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 110+/-13) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 120+/-7) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 80+/-5) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN TNF-alpha) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (CD 130+/-12) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (NN pretreatment) (NNS levels)))))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD was) (NP (DT no) (NN change)) (PP (IN after) (NP (NN saline) (NN infusion))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN gene) (NN expression)) (PP (IN of) (NP (NP (NN FAT/CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN TNF-alpha)))) (PP (IN in) (NP (JJ subcutaneous) (NN adipose) (NN tissue)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (JJ circulating) (NNS lipids)) (ADJP (JJ independent) (PP (IN of) (NP (NN insulin)))))))))) (CC and) (SBAR (IN that) (S (NP (JJ prolonged) (NN hyperlipidemia)) (VP (MD may) (ADVP (RB therefore)) (VP (VB contribute) (PP (TO to) (NP (NP (VBN increased) (JJ fat) (NN metabolism)) (CC and) (NP (NN storage)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (DT the) (VBN increased) (NN expression)) (PP (IN of) (NP (DT these) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN gene) (NN expression)) (PP (IN of) (NP (NP (NN FAT/CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN TNF-alpha)))) (PP (IN in) (NP (JJ subcutaneous) (NN adipose) (NN tissue)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (JJ circulating) (NNS lipids)) (ADJP (JJ independent) (PP (IN of) (NP (NN insulin)))))))))) (CC and) (SBAR (IN that) (S (NP (JJ prolonged) (NN hyperlipidemia)) (VP (MD may) (ADVP (RB therefore)) (VP (VB contribute) (PP (TO to) (NP (NP (VBN increased) (JJ fat) (NN metabolism)) (CC and) (NP (NN storage)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (DT the) (VBN increased) (NN expression)) (PP (IN of) (NP (DT these) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN gene) (NN expression)) (PP (IN of) (NP (NP (NN FAT/CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN TNF-alpha)))) (PP (IN in) (NP (JJ subcutaneous) (NN adipose) (NN tissue)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (JJ circulating) (NNS lipids)) (ADJP (JJ independent) (PP (IN of) (NP (NN insulin)))))))))) (CC and) (SBAR (IN that) (S (NP (JJ prolonged) (NN hyperlipidemia)) (VP (MD may) (ADVP (RB therefore)) (VP (VB contribute) (PP (TO to) (NP (NP (VBN increased) (JJ fat) (NN metabolism)) (CC and) (NP (NN storage)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (DT the) (VBN increased) (NN expression)) (PP (IN of) (NP (DT these) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN HEK-293) (NNS cells))) (PP (IN for) (NP (CD 2) (NN min))) (PP (IN with) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT a) (JJ mAChR) (NN agonist)) (, ,) (NP (JJ lysophosphatidic) (NN acid)) (, ,) (CC or) (NP (NN ATP))) (, ,)))) (VP (VBN followed) (PP (IN by) (NP (NN agonist) (NN washout))))) (, ,) (ADVP (RB strongly)) (S (VP (VBN increased) (PRN (-LRB- -LRB-) (PP (IN by) (NP (JJ 2-3-fold))) (-RRB- -RRB-)) (NP (NP (NP (JJ maximal) (NN _PROT1_) (NN stimulation)) (PRN (-LRB- -LRB-) (NP (QP (VBN measured) (CD >/=40)) (NN min) (JJ later)) (-RRB- -RRB-))) (PP (IN by) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (CC and) (NP (JJ platelet-derived) (NN growth) (NN factor)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)))) (, ,) (CC and) (NP (NP (ADJP (RB largely) (VBN enhanced)) (NN _PROT_) (NN sensitivity)) (PP (TO to) (NP (DT these) (NN RTK) (NNS agonists))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN HEK-293) (NNS cells))) (PP (IN for) (NP (CD 2) (NN min))) (PP (IN with) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT a) (JJ mAChR) (NN agonist)) (, ,) (NP (JJ lysophosphatidic) (NN acid)) (, ,) (CC or) (NP (NN ATP))) (, ,)))) (VP (VBN followed) (PP (IN by) (NP (NN agonist) (NN washout))))) (, ,) (ADVP (RB strongly)) (S (VP (VBN increased) (PRN (-LRB- -LRB-) (PP (IN by) (NP (JJ 2-3-fold))) (-RRB- -RRB-)) (NP (NP (NP (JJ maximal) (NN _PROT1_) (NN stimulation)) (PRN (-LRB- -LRB-) (NP (QP (VBN measured) (CD >/=40)) (NN min) (JJ later)) (-RRB- -RRB-))) (PP (IN by) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (CC and) (NP (JJ platelet-derived) (NN growth) (NN factor)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)))) (, ,) (CC and) (NP (NP (ADJP (RB largely) (VBN enhanced)) (NN _PROT2_) (NN sensitivity)) (PP (TO to) (NP (DT these) (NN RTK) (NNS agonists))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN HEK-293) (NNS cells))) (PP (IN for) (NP (CD 2) (NN min))) (PP (IN with) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT a) (JJ mAChR) (NN agonist)) (, ,) (NP (JJ lysophosphatidic) (NN acid)) (, ,) (CC or) (NP (NN ATP))) (, ,)))) (VP (VBN followed) (PP (IN by) (NP (NN agonist) (NN washout))))) (, ,) (ADVP (RB strongly)) (S (VP (VBN increased) (PRN (-LRB- -LRB-) (PP (IN by) (NP (JJ 2-3-fold))) (-RRB- -RRB-)) (NP (NP (NP (JJ maximal) (NN _PROT_) (NN stimulation)) (PRN (-LRB- -LRB-) (NP (QP (VBN measured) (CD >/=40)) (NN min) (JJ later)) (-RRB- -RRB-))) (PP (IN by) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (CC and) (NP (JJ platelet-derived) (NN growth) (NN factor)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)))) (, ,) (CC and) (NP (NP (ADJP (RB largely) (VBN enhanced)) (NN _PROT2_) (NN sensitivity)) (PP (TO to) (NP (DT these) (NN RTK) (NNS agonists))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT The) (NN body) (NN mass) (NN index)) (PRN (-LRB- -LRB-) (NP (NN BMI)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN plasma) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NN serotonin)) (, ,) (NP (NP (NP (NP (NN thyroxine)) (PRN (-LRB- -LRB-) (NP (NN T4)) (-RRB- -RRB-))) (, ,) (NP (NP (NN triiodothyronine)) (PRN (-LRB- -LRB-) (NP (NN T3)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ reverse) (NN triiodothyronine)) (PRN (-LRB- -LRB-) (NP (NN rT3)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN serum))))) (VP (VBD were) (VP (VBN evaluated) (PP (IN for) (NP (DT each) (NN subject))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT1_)) (, ,) (NP (NNS _PROT2_)) (CC and) (NP (NNS _PROT_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT1_)) (, ,) (NP (NNS _PROT_)) (CC and) (NP (NNS _PROT2_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT1_)) (, ,) (NP (NNS _PROT_)) (CC and) (NP (NNS _PROT_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT_)) (, ,) (NP (NNS _PROT1_)) (CC and) (NP (NNS _PROT2_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT_)) (, ,) (NP (NNS _PROT1_)) (CC and) (NP (NNS _PROT_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT_)) (, ,) (NP (NNS _PROT_)) (CC and) (NP (NNS _PROT1_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ total) (NN intake)) (PP (IN of) (NP (NNS _PROT1_)))) (VP (VBD was) (VP (ADVP (RB inversely)) (VBN correlated) (PP (IN with) (NP (NP (NP (NP (DT the) (NN plasma) (JJ total) (NN _PROT2_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN TC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.236)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN LDL-C)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.220)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))))) (, ,) (PP (IN after) (NP (NP (DT the) (NN adjustment)) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN body) (NN mass) (NN index)) (CC and) (NP (JJ total) (NN energy) (NN intake)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ total) (NN intake)) (PP (IN of) (NP (NNS _PROT1_)))) (VP (VBD was) (VP (ADVP (RB inversely)) (VBN correlated) (PP (IN with) (NP (NP (NP (NP (DT the) (NN plasma) (JJ total) (NN _PROT_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN TC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.236)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN LDL-C)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.220)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))))) (, ,) (PP (IN after) (NP (NP (DT the) (NN adjustment)) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN body) (NN mass) (NN index)) (CC and) (NP (JJ total) (NN energy) (NN intake)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ total) (NN intake)) (PP (IN of) (NP (NNS _PROT_)))) (VP (VBD was) (VP (ADVP (RB inversely)) (VBN correlated) (PP (IN with) (NP (NP (NP (NP (DT the) (NN plasma) (JJ total) (NN _PROT1_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN TC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.236)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN LDL-C)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.220)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))))) (, ,) (PP (IN after) (NP (NP (DT the) (NN adjustment)) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN body) (NN mass) (NN index)) (CC and) (NP (JJ total) (NN energy) (NN intake)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN protein) (NN disruption)) (PP (IN of) (NP (ADJP (ADJP (JJ cholinergic)) (CC and) (NP (NN growth) (NN factor) (NN _PROT2_) (NN _PROT2_))) (NNS signals)))) (VP (MD could) (VP (VB underlie) (NP (NP (ADJP (ADJP (JJ cognitive)) (CC and) (ADJP (JJ neurodegerative))) (NNS aspects)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN beta) (NN _PROT1_) (NN protein) (NNS fragments)) (VP (VBD had) (NP (NP (JJ diverse) (NNS effects)) (PP (IN on) (NP (NP (JJ phosphoinositide-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PI-PLC)) (-RRB- -RRB-))))) (SBAR (IN as) (S (VP (VBN assayed) (PP (IN in) (NP (NN rat) (JJ cortical) (NNS membranes))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT2_) (NN _PROT2_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT2_) (NN _PROT2_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT1_) (NN _PROT1_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT2_) (NN _PROT2_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT1_) (NN _PROT1_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT1_) (NN _PROT1_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT2_)))))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS responses)) (PP (IN of) (NP (NP (NP (NN serum) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))))) (PP (TO to) (NP (NP (NP (DT the) (JJ serotonergic) (NN HT1A) (NN agonist) (NN buspirone)) (PRN (-LRB- -LRB-) (NP (CD 15) (NN mg) (NN p.o.)) (-RRB- -RRB-))) (CC or) (NP (NP (DT the) (NN HTD1) (NN agonist) (NN sumatriptan)) (PRN (-LRB- -LRB-) (NP (NP (CD 6) (NN mg)) (VP (VBN injected) (ADVP (RB subcutaneously)))) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN evaluated) (PP (IN in) (NP (CD 7) (JJ normal) (NNS men))) (PP (CC either) (PP (IN in) (NP (JJ basal) (NNS conditions))) (CC or) (PP (IN during) (NP (NP (DT an) (NN _PROT2_) (PRN (-LRB- -LRB-) (NP (NP (NN 0.15) (NN iu/kg)) (PP (IN as) (NP (DT an) (NN i.v.) (NN bolus)))) (-RRB- -RRB-)) (NN tolerance) (NN test)) (PRN (-LRB- -LRB-) (NP (NN ITT)) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Stimulation)) (PP (IN of) (NP (JJ 5HT-1D) (NNS receptors))) (PP (IN with) (NP (NN sumatriptan)))) (VP (VBD was) (ADJP (JJ unable) (PP (TO to) (NP (NP (NP (NN change)) (CC neither) (NP (NN AVP))) (CC nor) (NP (NP (NN _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Induction)) (PP (IN by) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))))) (CC and) (NP (NP (NNS enzymes)) (PP (IN of) (NP (JJ fatty) (NN acid) (NN oxidation))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ alters) (PP (IN in) (NP (JJ pancreatic) (NNS islets))) (NP (NP (DT the) (NN mRNA)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NNS enzymes)) (PP (IN of) (NP (JJ free) (JJ fatty) (NN acid) (NN metabolism)))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-2)) (-RRB- -RRB-)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN overexpression)) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA)) (PP (IN by) (NP (JJR more) (IN than) (RB 10-fold))) (PP (IN in) (NP (NP (NP (NN epididymal)) (, ,) (NP (NN retroperitoneal)) (, ,) (CC and) (NP (NP (JJ subcutaneous) (JJ fat) (NN tissue)) (PP (IN of) (NP (JJ normal))))) (, ,) (CONJP (CC but) (RB not)) (PP (IN of) (NP (JJ leptin-receptor-defective) (JJ obese) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (PP (IN By) (S (ADVP (RB directly)) (VP (VBG regulating) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NNS enzymes)) (PP (PP (IN of) (NP (JJ free) (JJ fatty) (NN acid) (NN metabolism))) (CC and) (PP (IN of) (NP (NN _PROT1_)))))))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ controls) (NP (NP (JJ intracellular) (NN triglyceride) (NN content)) (PP (IN of) (NP (NP (JJ certain) (NNS nonadipocytes)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NNS adipocytes)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NP (DT the) (NNS MAPKs)) (, ,) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN PMA)))))))) (VP (VBD was) (VP (VBN inhibited) (PP (PP (IN by) (NP (NP (NN downregulation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-)))))) (, ,) (PP (IN by) (NP (DT the) (NN tyrosine) (NN kinase) (NN inhibitor) (NN genistein))) (CC and) (PP (IN by) (NP (NP (NP (NP (NN MAPK) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN MEK)) (-RRB- -RRB-))) (NN inhibitor)) (, ,) (NP (NN PD98059))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ activates) (NP (DT the) (JJ 42/44kDa) (NNS MAPKs)) (PP (IN through) (NP (NP (DT a) (NN signal) (NN transduction) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBZ involves) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN AVP-V1) (NN receptor)) (, ,) (NP (NN tyrosine) (NN kinase)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN MEK)))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Similarly)) (, ,) (NP (NP (NN carbachol)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN DDAVP))) (, ,)) (VP (VBD induced) (NP (NP (DT a) (JJ significant) (NN increase)) (PP (IN in) (NP (NP (NP (JJ membrane-associated) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN enzyme) (NN activity))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (PRP _PROT1_)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN distribution)) (PP (IN of) (NP (DT any) (NN _PROT2_) (NN isoform)))))) (VP (VBD tested)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Treatment)) (PP (IN with) (NP (PRN (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NN -trifluoro-ABA)))) (ADVP (RB strongly)) (VP (VBD inhibited) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NN I-1)) (VP (VBN encoded) (PP (IN by) (NP (NN RAmy1A)))))) (PP (IN in) (NP (NP (DT the) (JJ aleurone) (NNS layers)) (PP (IN of) (NP (NN embryoless) (NNS half-seeds)))))) (PP (IN at) (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NP (NN transcription)) (, ,) (NP (NN protein) (NN synthesis)) (, ,) (CC and) (NP (NN enzyme) (NN activity))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Chronic) (JJ central) (NN _PROT1_) (NN infusion)) (VP (VP (VBZ enhances) (NP (JJ insulin-stimulated) (NN glucose) (NN metabolism))) (CC and) (VP (VBZ favors) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NNS _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT1_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT1_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT1_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (NP (NN Melatonin)) (VP (VBZ inhibits) (NP (NP (NN _PROT1_) (NN response)) (PP (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))) (, ,) (CC but) (PP (RB not) (TO to) (NP (NN angiotensin) (CD II)))) (PP (IN in) (NP (JJ normal) (NNS men))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN In) (S (NP (NN order)) (VP (TO to) (VP (VB establish) (SBAR (IN whether) (S (NP (NN melatonin)) (VP (VBZ alters) (NP (ADJP (ADJP (JJ basal)) (CC and/or) (ADJP (JJ stimulated))) (NN _PROT1_) (NN secretion))))))))) (, ,) (S (NP (CD 18) (JJ normal) (NNS men)) (VP (VBD were) (VP (VBN treated) (PRN (-LRB- -LRB-) (NP (NN p.o.)) (-RRB- -RRB-)) (PP (IN with) (NP (NP (NP (NP (NP (NP (ADJP (QP (CD 6) (CC or) (CD 12)) (NN mg)) (NN melatonin)) (CC or) (NP (NN placebo))) (PP (PP (IN in) (NP (NP (JJ basal) (NNS conditions)) (PRN (-LRB- -LRB-) (NP (NN N-6) (NNS subjects)) (-RRB- -RRB-)))) (CC or) (PP (RB concomitantly) (TO to) (NP (NP (DT the) (NN administration)) (PP (IN of) (NP (NN _PROT2_))))))) (-LRB- -LRB-) (NP (CD O.15) (NN IU/kg) (NN body) (NN weight)) (PP (IN in) (NP (DT an) (NN i.v.) (NN bolus))) (-RRB- -RRB-)) (PRN (-LRB- -LRB-) (NP (NN N-6) (NNS subjects)) (-RRB- -RRB-))) (CC or) (NP (NP (NN angiotensin) (CD II)) (PRN (-LRB- -LRB-) (NP (NP (NP (VBG increasing) (NNS doses)) (PP (IN of) (NP (QP (CD 4) (, ,) (CD 8) (CC and) (CD 16)) (NN ng/kg/min)))) (, ,) (PP (IN at) (NP (NP (NNS intervals)) (PP (IN of) (NP (CD 20) (NN min)))))) (-RRB- -RRB-)))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))) (VP (VBD was) (ADVP (RB significantly)) (VP (VBN reduced) (PP (IN by) (NP (NN melatonin) (NN treatment))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Effect)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion))) (PP (IN on) (NP (NP (DT the) (JJ abnormal) (NN _PROT2_) (NN response)) (PP (TO to) (NP (NN hypoglycaemia))) (PP (IN in) (NP (JJ _PROT_) (NNS diabetics)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Effect)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion))) (PP (IN on) (NP (NP (DT the) (JJ abnormal) (NN _PROT_) (NN response)) (PP (TO to) (NP (NN hypoglycaemia))) (PP (IN in) (NP (JJ _PROT2_) (NNS diabetics)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Effect)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT_) (NN secretion))) (PP (IN on) (NP (NP (DT the) (JJ abnormal) (NN _PROT1_) (NN response)) (PP (TO to) (NP (NN hypoglycaemia))) (PP (IN in) (NP (JJ _PROT2_) (NNS diabetics)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN Since) (S (NP (JJ previous) (NNS studies)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN AVP) (NN secretion)) (VP (VBZ is) (VP (VBN influenced) (PP (IN by) (NP (NP (DT the) (NN persistence)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD wondered) (SBAR (IN whether) (S (NP (DT this) (NN factor)) (ADVP (RB also)) (VP (VBZ regulates) (NP (NN _PROT2_) (NN secretion))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (NP (JJ Case-control) (NN study)) (: :) (S (NP (NP (DT the) (JJ _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycaemia)))) (VP (VBD was) (VP (VBN measured) (PP (IN in) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ diabetic))) (NNS patients)) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (JJ residual) (JJ endogenous) (NN _PROT_) (NN secretion)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (NP (JJ Case-control) (NN study)) (: :) (S (NP (NP (DT the) (JJ _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT_) (NN hypoglycaemia)))) (VP (VBD was) (VP (VBN measured) (PP (IN in) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ diabetic))) (NNS patients)) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (JJ residual) (JJ endogenous) (NN _PROT2_) (NN secretion)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (NP (JJ Case-control) (NN study)) (: :) (S (NP (NP (DT the) (JJ _PROT_) (NN response)) (PP (TO to) (NP (JJ _PROT1_) (NN hypoglycaemia)))) (VP (VBD was) (VP (VBN measured) (PP (IN in) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ diabetic))) (NNS patients)) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (JJ residual) (JJ endogenous) (NN _PROT2_) (NN secretion)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Blood) (NNS samples)) (PP (IN for) (NP (NN _PROT1_) (NN assay)))) (VP (VBD were) (VP (VBN taken) (PP (ADVP (RB just)) (PP (IN before) (NP (NP (NP (DT the) (JJ rapid) (NN injection)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN time) (CD 0)) (-RRB- -RRB-)))) (CC and) (PP (IN at) (NP (NN time))) (NP (QP (CD 15) (, ,) (CD 30) (, ,) (CD 45) (CC and) (CD 60)) (NN min))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (DT a) (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion)) (VP (VBZ exerts) (NP (NP (DT a) (JJ partial) (JJ protective) (NN action)) (PP (IN against) (NP (NP (DT the) (JJ hypothalamic-pituitary) (NN disorder)) (VP (VBG affecting) (NP (NP (DT the) (JJ _PROT2_) (JJ secretory) (NN system)) (PP (IN in) (NP (NN IDDM)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBD led) (S (NP (PRP us)) (VP (TO to) (VP (VB conclude) (SBAR (IN that) (S (NP (NP (NN inositol) (NN trisphosphate)) (NN [corrected) (-RRB- -RSB-)) (VP (VBZ causes) (NP (NN Ca2+) (NN mobilization)) (PP (IN by) (NP (NP (JJ muscarinic) (NN activation)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG leading) (PP (TO to) (NP (NP (JJ intracellular) (NN translocation)) (PP (IN of) (NP (NN _PROT2_) (NNS granules))) (PP (TO to) (NP (NP (DT the) (JJ ready-releasable) (NN pool)) (PP (IN in) (NP (JJ pancreatic) (NNS beta-cells))))))) (PP (IN via) (NP (NP (JJ Ca2+/calmodulin-dependent) (NN phosphorylation)) (PP (IN of) (NP (NN myosin) (NN light) (NNS chains)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN DNase1) (NNS footprints)) (VP (VBP suggest) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (QP (IN at) (JJS least) (CD three)) (NNS types)) (PP (IN of) (NP (NN transcription) (NNS factors))))) (PP (IN in) (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN regulation)) (PP (IN of) (NP (NN _PROT1_) (NNS genes))) (PP (IN by) (NP (NN _PROT2_)))) (ADVP (RB therefore)) (VP (VBZ involves) (NP (NP (DT an) (NN interplay)) (PP (IN of) (NP (NP (QP (IN at) (JJS least) (CD three)) (JJ different) (NNS types)) (PP (IN of) (NP (NN transcription) (NN factor))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Analyses)) (PP (IN of) (NP (NP (NN hormone) (NN regulation)) (PP (IN of) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN mRNA)) (PP (IN for) (NP (DT the) (NN aleurone) (NN RNase)))))))))) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NP (DT the) (NN pattern)) (PP (IN for) (NP (NN _PROT1_))))) (, ,) (S (NP (NN mRNA) (NNS levels)) (VP (VBD increased) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ _PROT2_) (NN _PROT2_))))))) (, ,) (CC and) (S (NP (PRP$ its) (NN antagonist) (JJ abscisic) (NN acid)) (VP (VBD prevented) (NP (DT this) (NN effect))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Quantitative) (NNS studies)) (PP (IN at) (NP (JJ early) (NNS times)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN cycloheximide) (NN treatment)) (PP (IN of) (NP (NN aleurone) (NNS layers)))) (VP (VBD increased) (NP (NN mRNA) (NNS levels)) (ADVP (RB 4-fold)) (, ,) (SBAR (IN whereas) (S (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC plus) (NP (NN cycloheximide) (NN treatment))))) (VP (VBD was) (VP (VBN required) (S (VP (TO to) (VP (VB increase) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (PP (TO to) (NP (DT the) (JJ same) (NN extent)))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (PP (IN at) (NP (VBG increasing) (NN _PROT1_) (NNS concentrations))) (, ,) (NP (NP (VBG increasing) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN barley)) (PRN (-LRB- -LRB-) (NP (NN Hordeum) (NN vulgare)) (-RRB- -RRB-))) (NNS cells)))) (VP (VBD showed) (NP (NP (DT the) (VBN enhanced) (NP (NP (NN _PROT2_) (NN secretion)) (CC and) (NP (NN vacuolation))) (NN characteristic)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN response)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (PP (IN at) (NP (VBG increasing) (NN _PROT1_) (NNS concentrations))) (, ,) (NP (NP (VBG increasing) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN barley)) (PRN (-LRB- -LRB-) (NP (NN Hordeum) (NN vulgare)) (-RRB- -RRB-))) (NNS cells)))) (VP (VBD showed) (NP (NP (DT the) (VBN enhanced) (NP (NP (NN _PROT_) (NN secretion)) (CC and) (NP (NN vacuolation))) (NN characteristic)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (PP (IN at) (NP (VBG increasing) (NN _PROT_) (NNS concentrations))) (, ,) (NP (NP (VBG increasing) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN barley)) (PRN (-LRB- -LRB-) (NP (NN Hordeum) (NN vulgare)) (-RRB- -RRB-))) (NNS cells)))) (VP (VBD showed) (NP (NP (DT the) (VBN enhanced) (NP (NP (NN _PROT1_) (NN secretion)) (CC and) (NP (NN vacuolation))) (NN characteristic)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN satiety) (NN factor)) (SBAR (WHNP (WDT which)) (S (VP (VBZ acts) (PP (IN within) (NP (DT the) (NN hypothalamus))) (S (VP (TO to) (VP (VB decrease) (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NP (NP (JJ several) (NNS neuropeptides)) (VP (VBG stimulating) (NP (NN food) (NN intake)))) (PRN (-LRB- -LRB-) (PP (IN among) (NP (PRP them))) (, ,) (NP (NN _PROT2_) (NN _PROT2_) (CD [NPY)) (-RRB- -RSB-) (-RRB- -RRB-)))))))))))) (, ,) (SBAR (IN while) (S (VP (VBG increasing) (NP (NP (DT those)) (SBAR (WHNP (WDT that)) (S (VP (VBP inhibit) (NP (NN food) (NN intake)))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (DT the) (JJ above) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT a) (JJ direct) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB promote) (NP (NN TRH) (NN biosynthesis)) (PP (IN through) (NP (NP (NNS actions)) (PP (IN on) (NP (NN TRH) (NNS neurons)))))))))))))) (, ,) (NP (NP (NN addition)) (PP (IN of) (NP (NN a-MSH)))) (VP (VBD produced) (NP (NP (DT a) (CD 3.5) (NN fold) (NN increase)) (PP (IN in) (NP (NP (NN TRH) (NN biosynthesis)) (CC and) (NP (NN release))))) (, ,) (SBAR (IN whereas) (S (NP (NN _PROT2_) (NN treatment)) (VP (VBD suppressed) (NP (NN ~3) (NN fold) (NN proTRH) (NN biosynthesis)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (VBN increased) (NN _PROT1_) (NN signaling)) (PP (TO to) (NP (NP (DT the) (NP (NN _PROT2_)) (CC and) (NP (JJ POMC) (NNS neurons))) (PP (IN in) (NP (DT the) (NN ARC)))))))) (PP (IN by) (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (VBG circulating) (NN _PROT_))))) (PP (IN during) (NP (JJ normal) (NN feeding)))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (VBN increased) (NN _PROT1_) (NN signaling)) (PP (TO to) (NP (NP (DT the) (NP (NN _PROT_)) (CC and) (NP (JJ POMC) (NNS neurons))) (PP (IN in) (NP (DT the) (NN ARC)))))))) (PP (IN by) (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (VBG circulating) (NN _PROT2_))))) (PP (IN during) (NP (JJ normal) (NN feeding)))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (VBN increased) (NN _PROT_) (NN signaling)) (PP (TO to) (NP (NP (DT the) (NP (NN _PROT1_)) (CC and) (NP (JJ POMC) (NNS neurons))) (PP (IN in) (NP (DT the) (NN ARC)))))))) (PP (IN by) (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (VBG circulating) (NN _PROT2_))))) (PP (IN during) (NP (JJ normal) (NN feeding)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (ADVP (RB Rapidly)) (VP (VP (VBZ Inhibits) (NP (NP (JJ Hypothalamic) (NN _PROT2_) (NN _PROT2_)) (NN Secretion))) (CC and) (VP (VBZ Stimulates) (NP (NP (JJ Corticotropin-Releasing) (NN Hormone) (NN Secretion)) (PP (IN in) (NP (JJ Adrenalectomized) (NNS Mice)))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (MD may) (ADVP (RB rapidly)) (VP (VBP inhibit) (NP (NN food) (NN intake)) (PP (IN by) (S (VP (VBG altering) (NP (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NNS neuropeptides)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN stimulator)) (PP (IN of) (NP (NN food) (NN intake)))) (, ,) (CC and/or) (NP (NP (JJ corticotropin-releasing) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN CRH)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (DT an) (NN inhibitor)) (PP (IN of) (NP (NN food) (NN intake)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS concentrations)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN CRH)) (PP (IN in) (NP (JJ specific) (JJ hypothalamic) (NNS regions))))) (NNS [i.e.)) (, ,) (NP (NP (NP (JJ arcuate) (NN nucleus)) (PRN (-LRB- -LRB-) (NP (NN ARC)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ paraventricular) (NN nucleus)) (PRN (-LRB- -LRB-) (NP (NN PVN)) (-RRB- -RRB-))) (, ,) (NP (JJ ventromedial) (NN nucleus)) (CC and) (NP (JJ dorsomedial) (NN nucleus))))) (-RRB- -RSB-) (PP (IN of) (NP (ADJP (CD 7-) (TO to) (JJ 8-wk-old)) (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ ob/ob))) (NNS mice)))) (PP (IN at) (NP (QP (CD 1) (CC or) (CD 3)) (NN h))) (PP (IN after) (NP (JJ intracerebroventricular) (NN _PROT2_) (NN administration)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT No) (JJ rapid-onset) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (JJ hypothalamic) (NN _PROT2_)) (CC or) (NP (NN CRH) (NNS concentrations))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (JJ intact) (NNS mice))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NP (JJ hypothalamic) (NNS preparations)) (PP (IN from) (NP (JJ intact) (NNS mice)))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN _PROT2_)) (CC or) (NP (NN CRH) (NN secretion))))))) |ET|
+1 |BT| (S1 (S (PP (IN Within) (NP (NP (CD 20) (NN min)) (PP (IN after) (NP (NP (NN exposure)) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (JJ hypothalamic) (NNS preparations)) (VP (VBN obtained) (PP (IN from) (NP (JJ adrenalectomized) (NNS mice))))))) (VP (VBD was) (VP (VBN lowered) (PP (IN by) (NP (NP (CD 27) (NN %)) (CC and) (NP (NN CRH) (NN secretion)))))) (VP (VBD was) (VP (VBN elevated) (PP (IN by) (NP (CD 51) (NN %))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ current) (NN study)) (VP (VBZ demonstrates) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB rapidly)) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NN _PROT2_)) (CC and) (NP (NN CRH)))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT these) (NNS actions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN within) (NP (DT the) (NN hypothalamus)))) (VP (VBP are) (VP (VBN restrained) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN corticosterone))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ current) (NN study)) (VP (VBZ demonstrates) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB rapidly)) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NN _PROT_)) (CC and) (NP (NN CRH)))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT these) (NNS actions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN within) (NP (DT the) (NN hypothalamus)))) (VP (VBP are) (VP (VBN restrained) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN corticosterone))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ current) (NN study)) (VP (VBZ demonstrates) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB rapidly)) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NN _PROT1_)) (CC and) (NP (NN CRH)))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT these) (NNS actions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN within) (NP (DT the) (NN hypothalamus)))) (VP (VBP are) (VP (VBN restrained) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN corticosterone))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN as) (NP (NP (DT a) (NN modulator)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (PP (IN On) (DT the) (NN basis) (IN of) (NP (NP (JJ far-Western) (NN blot)) (CC and) (NP (NP (NP (NN plasmon) (NN resonance)) (PRN (-LRB- -LRB-) (NP (NN BIAcore)) (-RRB- -RRB-))) (NNS experiments)))) (, ,) (NP (PRP we)) (VP (VBP show) (ADVP (RB here)) (SBAR (IN that) (S (NP (NP (NP (JJ recombinant) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN bPrP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN 25-242)) (-RRB- -RRB-))) (ADVP (RB strongly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (JJ catalytic) (JJ alpha/alpha) (`` ') (NNS subunits)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN termed) (S (PRN (`` ') (NP (NN casein) (NN kinase) (CD 2)) ('' ')))) (-RRB- -RRB-)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ counteracts) (NP (NP (DT the) (NN inhibition)) (PP (IN of) (NP (NP (NN calmodulin) (NN phosphorylation)) (VP (VBN promoted) (PP (IN by) (NP (NP (DT the) (JJ regulatory) (NN beta) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (VBN truncated) (NN form)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBG encompassing) (NP (NP (DT the) (JJ C-terminal) (NN domain)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 105-242))) (-RRB- -RRB-))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_)))) (CC but) (VP (VBZ does) (RB not) (VP (VB affect) (NP (PRP$ its) (JJ catalytic) (NN activity))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP disclose) (NP (NP (DT the) (NN potential)) (PP (IN of) (NP (DT the) (NN _PROT1_))) (S (VP (TO to) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ pleiotropic) (NN _PROT_) (NN _PROT_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (RB particularly) (JJ abundant) (PP (IN in) (NP (DT the) (NN brain)))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP disclose) (NP (NP (DT the) (NN potential)) (PP (IN of) (NP (DT the) (NN _PROT1_))) (S (VP (TO to) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ pleiotropic) (NN _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (RB particularly) (JJ abundant) (PP (IN in) (NP (DT the) (NN brain)))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP disclose) (NP (NP (DT the) (NN potential)) (PP (IN of) (NP (DT the) (NN _PROT_))) (S (VP (TO to) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ pleiotropic) (NN _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (RB particularly) (JJ abundant) (PP (IN in) (NP (DT the) (NN brain)))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN _PROT2_) (NN turnover)) (PP (IN in) (NP (NP (NN endometrium)) (PP (IN of) (NP (NNS ewes)))))) (VP (VBZ is) (VP (VBN influenced) (PP (IN by) (NP (NP (NN stage)) (PP (IN of) (NP (NP (NP (DT the) (NN estrous) (NN cycle)) (, ,) (NP (NN pregnancy)) (, ,) (CC and) (NP (JJ intrauterine) (NN infusion))) (PP (IN of) (NP (NN ovine) (NN conceptus) (JJ secretory) (NNS proteins))))))))))) |ET|
+1 |BT| (S1 (S (NP (CD Three) (NNS experiments)) (PRN (-LRB- -LRB-) (NP (NNP Exp)) (-RRB- -RRB-)) (VP (VBD assessed) (NP (NP (DT the) (NN influence)) (PP (IN of) (NP (NP (NN stage)) (PP (IN of) (NP (NP (DT the) (NN estrous) (NN cycle)) (, ,) (NP (NN pregnancy)) (, ,) (CC and) (NP (NP (JJ intrauterine) (NN infusion)) (PP (IN of) (NP (NP (JJ ovine) (NN conceptus) (JJ secretory) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN oCSP)) (-RRB- -RRB-))))))))) (PP (IN on) (NP (NP (NN turnover)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (JJ putative) (NN second-messenger)) (PP (IN for) (NP (JJ _PROT2_) (NN secretion))) (PP (IN of) (NP (NN prostaglandin) (NN F2) (NN alpha)))) (-RRB- -RRB-))))))) (PP (IN in) (NP (NN ovine) (NN endometrium))) (PP (IN during) (NP (NP (NP (NN luteolysis)) (CC and) (NP (JJ maternal) (NN recognition))) (PP (IN of) (NP (NN pregnancy)))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT each) (NN Exp))) (, ,) (NP (ADJP (CD 100) (NN mg)) (NN endometrium)) (VP (VBD was) (VP (VP (VBN incubated) (, ,) (PP (IN in) (NP (NN duplicate))) (, ,) (PP (IN for) (NP (NP (CD 2) (NN h)) (PP (IN with) (NP (CD 10) (NN microCi) (NN [3H) (-RRB- -RSB-) (NN inositol)))))) (CC and) (VP (VBN treated) (PP (IN with) (NP (NP (ADJP (QP (CD 0) (CC or) (CD 100)) (NN nM)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 20) (NN min)))) (, ,) (ADVP (RB then))))) (S (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol) (NN mono-)) (, ,) (NP (NN bis-)) (, ,) (CC and) (NP (NP (NNS trisphosphates)) (PRN (-LRB- -LRB-) (NP (NP (NN IP1)) (, ,) (NP (NN IP2)) (, ,) (CC and) (NP (NN _PROT2_)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (VP (VBD were) (VP (VBN quantified)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS objectives)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD were) (S (VP (VP (TO to) (VP (VP (VB evaluate)) (CC and) (VP (VB compare) (NP (NP (DT the) (NNS actions)) (PP (IN of) (NP (NP (NP (NN endothelin-1)) (PRN (-LRB- -LRB-) (NP (NN ET-1)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))))) (PP (IN on) (NP (NP (NN 45Ca2+) (NN mobilization)) (PP (IN in) (NP (JJ permeabilized) (NN rat) (NN myometrial) (NNS cells))))))))) (CC and) (VP (TO to) (VP (VB examine) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NN inositol) (NN lipid) (NN cycle))) (PP (IN in) (NP (JJ intact) (NNS myocytes))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT All) (CD four) (NNS agonists)) (VP (VBD caused) (NP (NP (DT a) (JJ biphasic) (NN release)) (PP (IN of) (NP (NN 45Ca2+))) (PP (IN from) (NP (NP (JJ non-mitochondrial) (NN pool)) (PRN (-LRB- -LRB-) (NP (NN s)) (-RRB- -RRB-))))) (, ,) (PP (IN with) (NP (NP (DT the) (NN rank) (NN order)) (PP (IN of) (NP (NN potency))))))) (: :) (NP (NP (NN _PROT1_) (NN >) (NN PGF2) (NN alpha)) (NP (NN >) (NN ET-1) (NN >) (NN _PROT2_))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Endothelin-1)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NN _PROT2_) (NN _PROT2_) (NN accumulation)) (PP (IN at) (NP (NP (NNS concentrations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (SBAR (WHNP (WDT that)) (S (VP (VBD promoted) (NP (NN 45Ca2+) (NN efflux)))))))))))) (, ,) (IN whereas) (S (NP (NP (ADJP (QP (RB about) (CD 100) (NNS times)) (JJR higher)) (NNS concentrations)) (PP (IN of) (NP (NN PGF2) (NN alpha)))) (VP (VBD were) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (DT this) (NN signaling) (NN pathway)) (PP (IN in) (NP (JJ intact) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (VP (VBN concluded) (SBAR (IN that) (S (NP (NP (DT the) (JJ primary) (NN action)) (PP (IN of) (NP (NN PGF2) (NN alpha))) (PP (IN in) (NP (JJ myometrial) (NNS cells)))) (VP (VBZ is) (S (VP (TO to) (VP (VB enhance) (NP (NN Ca2+) (NN influx))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN ET-1))) (NNS receptors)) (VP (VBP are) (VP (VBN coupled) (PP (TO to) (NP (NN phospholipase) (NN C))) (, ,) (S (VP (VP (VBG generating) (NP (NN _PROT2_))) (CC and) (VP (VBG raising) (NP (NP (DT the) (JJ intracellular) (NN concentration)) (PP (IN of) (NP (JJ free) (NN Ca2+)))) (PP (IN from) (NP (ADJP (ADJP (JJ intracellular)) (CONJP (RB as) (RB well) (IN as)) (ADJP (JJ extracellular))) (NNS sources))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (DT a) (JJ biphasic) (NN increase)) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN Ca2+) (NN concentration)) (PP (IN of) (NP (NN porcine) (NN myometrial) (NNS cells)))))))) (: :) (NP (NP (NP (NN participation)) (PP (IN of) (NP (DT a) (ADJP (NN pertussis) (JJ toxin-insensitive)) (NN G-protein)))) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN Ca2+) (NN pool)) (, ,) (CC and) (NP (NN Ca2+) (NNS channels))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Administration)) (PP (IN of) (NP (NP (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 15) (NN sec)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN formation)) (PP (IN by) (NP (CD 61) (NN %)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN with) (NP (NP (NN pertussis) (NN toxin)) (PRN (-LRB- -LRB-) (NP (NP (NN PTX)) (, ,) (NP (CD 1) (NN microgram/ml))) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 2) (NN hr)))) (VP (VBD failed) (S (VP (TO to) (VP (VB alter) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT2_) (NN formation))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN U-73122)) (PRN (-LRB- -LRB-) (NP (CD 3) (NN microM)) (-RRB- -RRB-))) (ADVP (RB also)) (VP (VBD abolished) (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN formation))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ present) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (NN _PROT1_)) (VP (VBN given) (ADVP (ADVP (ADVP (RB subcutaneously)) (PRN (-LRB- -LRB-) (NP (NN SC)) (-RRB- -RRB-))) (CC and) (ADVP (ADVP (RB intracerebroventricularly)) (PRN (-LRB- -LRB-) (NP (NN ICV)) (-RRB- -RRB-)))))) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN glucagon)) (CC and) (NP (NN glucose)))))))))) (CC and) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (NP (DT these) (NNS variables)) (PP (IN of) (NP (NN suckling))))) (PP (IN in) (NP (JJ lactating) (NNS rats)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (JJ oxytocinergic) (NNS mechanisms)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Subcutaneous) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)) (ADVP (RB significantly))))) |ET|
+1 |BT| (S1 (S (NP (NP (CD Two) (NNS nanograms)) (S (NP (NP (NN _PROT1_)) (VP (VBN given) (NP (NN ICV)))) (VP (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)))) (CC but) (VP (VBD caused) (NP (NP (DT a) (JJ significant) (NN rise)) (PP (IN in) (NP (NN _PROT2_) (NNS levels)))) (PP (IN at) (NP (DT this) (NN time) (NN point))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT2_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT2_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT1_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT2_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT1_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Intracerebroventricular) (NNS injections)) (PP (IN of) (NP (ADJP (CD 200) (NN ng)) (NN _PROT1_)))) (VP (VBD caused) (NP (NP (DT a) (JJ significant) (NN rise)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN _PROT2_))) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (JJ nanogram) (NNS amounts)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN administered))))) (ADVP (RB ICV)) (VP (VBP cause) (NP (NP (DT a) (NN rise)) (PP (IN of) (NP (NN _PROT2_) (NNS levels))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN 8-OH-DPAT)) (ADVP (RB also)) (VP (VP (VBD increased) (NP (NN _PROT1_))) (CC and) (VP (VBD decreased) (NP (NP (NP (NN CCK)) (CC and) (NP (NN somatostatin))) (NNS levels))))) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT that)) (S (VP (VBD were) (VP (VBN blocked) (PP (IN by) (NP (NP (NN pretreatment)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN antagonist)))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN 8-OH-DPAT))) (PP (IN on) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN somatostatin)) (CC and) (NP (NN CCK))))))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ previous) (NNS experiments))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (PP (VBG following) (NP (NP (NN i.c.v.) (NN application)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBP are) (VP (VBN increased) (PP (IN through) (NP (DT a) (JJ cholinergic) (NN mechanism))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN influence)) (PP (IN of) (NP (NP (NN myrigalone) (NN B)) (, ,) (NP (NP (DT a) (NN _PROT1_)) (PP (IN from) (NP (NP (DT the) (JJ fruit) (NN exudate)) (PP (IN of) (NP (NNP Myrica) (FW gale) (FW L.)))))))) (PP (IN on) (NP (NP (ADJP (NN Cu) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN oxidation)) (PP (IN of) (NP (NP (JJ low) (NN density) (NN lipoprotein)) (PP (IN from) (NP (NN _PROT2_) (JJ fed) (NNS rabbits)))))))) (VP (VBD was) (VP (VBN investigated))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Immunohistochemical) (NN localization)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (ADJP (ADJP (JJ white)) (CC and) (ADJP (JJ brown))) (NN adipose) (NN tissue)))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB establish) (NP (NP (DT the) (NN cell) (NN type)) (VP (VBG expressing) (NP (NN _PROT1_))))))) (, ,) (NP (PRP we)) (ADVP (RB also)) (VP (VBD assessed) (NP (NP (NP (DT the) (NP (NN size)) (CC and) (NP (NN organization))) (PP (IN of) (NP (NP (NN lipid) (NNS droplets)) (, ,) (NP (NP (DT the) (JJ ultrastructural) (NNS features)) (PP (IN of) (NP (NN mitochondria)))) (, ,)))) (CC and) (NP (NP (DT the) (NP (NN presence)) (CC or) (NP (NN absence))) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT a) (JJ brown) (JJ fat-specific) (NN marker))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PP (IN of) (NP (JJ lean) (NNS animals))))) (, ,) (NP (NP (NP (JJ multilocular) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP)) (-RRB- -RRB-))) (JJ -positive) (NN brown) (NNS adipocytes)) (VP (VP (VBD had) (NP (JJ typical) (JJ brown) (NN mitochondria))) (CC and) (VP (VBD were) (ADJP (ADJP (JJ _PROT2_)) (, ,) (CC both) (PP (IN in) (NP (ADJP (ADJP (JJ fed)) (CC and) (ADJP (JJ fasted))) (NNS conditions)))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NP (DT the) (NN periphery)) (PP (IN of) (NP (DT the) (JJ interscapular) (JJ brown) (NN adipose) (NN tissue) (JJ depot))))) (, ,) (S (S (NP (NP (NP (ADJP (ADJP (JJ unilocular)) (, ,) (ADJP (JJ _PROT1_))) (NNS adipocytes)) (PRN (-LRB- -LRB-) (NP (NP (NN mean) (NN diameter)) (: :) (NP (CD 41.55) (NN microns))) (-RRB- -RRB-))) (PP (IN with) (NP (JJ white-type) (NN mitochondria)))) (VP (VBD were) (VP (VBN observed)))) (, ,) (CC and) (S (NP (DT these) (NNS cells)) (VP (VBD were) (NP (JJ _PROT2_))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (ADJP (ADJP (JJ obese)) (PRN (-LRB- -LRB-) (NP (NN db/db)) (-RRB- -RRB-))) (NNS animals))) (, ,) (NP (NN brown) (NN fat)) (VP (VBD was) (VP (VBN composed) (ADVP (RB mainly)) (PP (IN of) (NP (NP (JJ small) (ADJP (ADJP (JJ unilocular)) (, ,) (ADJP (JJ _PROT1_))) (NNS adipocytes)) (PRN (-LRB- -LRB-) (NP (NP (NN mean) (NN diameter)) (: :) (NP (CD 40.08) (NN microns))) (-RRB- -RRB-))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (ADVP (RB also)) (NP (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (JJ classical) (NN brown) (NNS adipocytes)) (VP (VBP differ) (PP (IN from) (NP (JJ white) (NNS adipocytes))) (, ,) (PP (CONJP (RB not) (RB only)) (PP (IN by) (NP (NP (PRP$ their) (NN morphology)) (CC and) (NP (NN _PROT1_) (NN expression)))) (, ,) (CONJP (CC but) (RB also)) (PP (IN by) (NP (NP (PRP$ their) (JJ apparent) (NN lack)) (PP (IN of) (NP (JJ detectable) (NN _PROT2_) (NN expression))))))))) |ET|
-1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (NP (CC or) (NP (NN _PROT2_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (NP (CC or) (NP (NN _PROT_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT2_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (NP (CC or) (NP (NN _PROT1_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT2_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT1_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT1_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT2_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT2_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN HvSPY) (NN coexpression)) (ADVP (RB largely)) (VP (VBD abolished) (NP (NP (JJ _PROT1_) (NN activity)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN promoter)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Signal) (NN transduction)) (PP (IN of) (NP (NN _PROT1_) (JJ _PROT1_) (JJ arachidonic) (NN acid) (NN release))) (PP (IN in) (NP (NN H9c2) (JJ cardiac) (NNS myoblasts)))) (: :) (NP (NP (NN role)) (PP (IN of) (NP (NN Ca2+)))) (CC and) (NP (NP (DT the) (ADJP (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_)) (NN activation)) (PP (IN of) (NP (NN p42) (JJ mitogen-activated) (NN protein) (NN kinase))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN Ca2+) (NN ionophore)) (, ,) (NP (NP (NN A23187)) (CC or) (NP (NN ionomycin))) (, ,)) (VP (VBD mimicked) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (SBAR (IN whereas) (S (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activator)) (, ,) (NP (NN TPA)) (, ,)) (ADVP (RB only)) (VP (VBD induced) (NP (NP (DT a) (JJ slight) (NN increase)) (PP (IN in) (NP (NN AA) (NN release)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT1_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT1_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ _PROT1_)) (CC or) (ADJP (JJ TPA-induced))) (NN activation)) (CC and) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (CD p42) (NN MAPK))))) (VP (VBD were) (VP (ADVP (RB completely)) (VBN blocked) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta))))))))) (, ,) (CC but) (S (ADVP (RB still)) (VP (VBD occurred) (, ,) (PP (ADVP (RB together)) (IN with) (NP (DT the) (JJ cytosolic) (NN PLA2) (NN mobility) (NN shift))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ external) (NN Ca2+))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN AA) (NN release)) (PP (IN in) (NP (NN H9c2) (NNS cells)))) (VP (VBZ is) (ADJP (JJ secondary) (PP (TO to) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN V1) (NN receptor/Gq) (NN protein/PLCP) (NN pathway))))))))) (, ,) (S (VP (VBG leading) (PP (TO to) (NP (NP (NP (DT an) (NN influx)) (PP (IN of) (NP (JJ extracellular) (NN Ca2+)))) (CC and) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT1_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT2_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT1_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT2_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT1_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT2_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Sympathetic) (NN inhibition)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN subtype) (NN expression)) (PP (IN in) (NP (JJ normal) (JJ fasting) (NNS rats))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB investigate) (NP (NP (JJ neural) (NNS effects)) (PP (IN on) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS UCPs)) (-RRB- -RRB-))))))))) (, ,) (S (NP (PRP we)) (VP (VBD studied) (NP (NP (ADJP (FW in) (FW vivo)) (NNS perturbations)) (VP (VBN intended) (S (VP (TO to) (VP (VB block) (NP (NP (JJ adrenergic) (NN input)) (PP (TO to) (NP (JJ peripheral) (NNS tissues))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT2_)) (, ,) (NP (NN _PROT1_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT1_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT2_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT1_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT2_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT1_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT2_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN modulation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VP (VBZ appears) (ADJP (JJ complex))) (CC and) (, ,) (PP (IN beyond) (NP (NP (DT a) (JJ causal) (NN effect)) (PP (IN of) (NP (NN SNA))) (ADVP (FW per) (FW se)))) (, ,) (VP (MD may) (VP (VB depend) (PP (IN on) (NP (NP (JJ concurrent) (NNS changes)) (PP (IN in) (NP (NP (NN plasma) (NN insulin)) (, ,) (NP (NN glucose)) (, ,) (CC and) (NP (JJ circulatory) (NNS hemodynamics))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (SBAR (IN in) (S (NP (NP (NN SN-56/OBR) (NNS cells)) (CC both) (NP (NP (NN CNTF)) (CC and) (NP (NN _PROT1_)))) (VP (VBP produce) (NP (NP (NP (NNS changes)) (PP (IN in) (NP (NN neurotransmitter)))) (CC and) (NP (NP (NN neuropeptide) (NN phenotype) (NN characteristic)) (PP (IN of) (NP (JJ cholinergic) (NNS neurons))))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NN choline) (NN acetyltransferase)) (CC and) (NP (JJ vasoactive) (JJ intestinal) (NN polypeptide))))) (, ,) (CC and) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_) (NN _PROT2_) (NN expression))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Possible) (NP (NP (JJ central) (JJ nervous) (NN system)) (PRN (-LRB- -LRB-) (NP (NN CNS)) (-RRB- -RRB-))) (NNS mechanisms)) (VP (MD could) (VP (VB mediate) (NP (DT these) (NNS responses)) (PP (IN in) (SBAR (IN that) (S (NP (NN leptin) (NNS receptors)) (VP (VBP are) (ADJP (JJ located) (PP (IN on) (NP (NP (JJ hypothalamic) (NNS neurons)) (SBAR (WHNP (WDT that)) (S (VP (VBP coexpress) (NP (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC or) (NP (NP (NN proopiomelanocortin)) (PRN (-LRB- -LRB-) (NP (JJ POMC)) (-RRB- -RRB-)))) (CC and) (NP (NP (DT both) (NNS peptides)) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN as) (NP (NP (NNS mediators)) (PP (IN of) (NP (NP (DT the) (NN CNS) (NN action)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ has) (VP (VBN been) (VP (VBN demonstrated) (S (VP (TO to) (VP (VP (VB decrease)) (CC or) (ADVP (RB down)) (VP (VB regulate) (NP (NN _PROT2_) (NN expression))) (CC and) (VP (VB increase) (NP (JJ POMC) (NN expression))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN 5-HT)) (CC and) (NP (NN _PROT1_))) (VP (VBP modulate) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB form) (NP (NP (DT a) (NN part)) (PP (IN of) (NP (NP (DT a) (JJ common) (NN output) (NN pathway)) (PP (IN for) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN appetite))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN studied) (NP (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN neomycin)) (, ,) (NP (NP (DT a) (JJ potent) (NN inhibitor)) (PP (IN of) (NP (NP (JJ inositol) (JJ phospholipid-specific) (NN phospholipase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))) (, ,))) (PP (IN on) (NP (NP (DT the) (NN germination)) (PP (IN of) (NP (NN rice) (NN seed)))))) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN aleurone) (NN layer)) (CC and) (NP (DT the) (JJ scutellar) (NNS tissues)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBD was) (VP (VBN shown) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ exogenous) (NN Ca2+))))) (, ,) (NP (NN neomycin)) (ADVP (RB markedly)) (VP (VP (VBD reduced) (NP (NP (DT the) (NP (NN germination) (NN speed)) (CC and) (NP (JJ seedling) (NN growth))) (PP (IN of) (NP (NN rice) (NNS seeds))))) (CC and) (VP (VBD inhibited) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT both) (JJ secretory) (NNS tissues)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB strongly)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN phosphoinositide-Ca2+) (NN signal) (NN transduction) (NN pathway)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NNS molecules)) (ADJP (RB closely) (JJ related) (PP (TO to) (NP (NP (DT the) (NN germination) (NNS processes)) (PP (IN of) (NP (NN rice) (NN seed))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN C75)) (VP (VP (VBD inhibited) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (JJ prophagic) (NN signal) (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN hypothalamus))))) (CC and) (VP (VBD acted) (PP (IN in) (NP (NP (DT a) (JJ _PROT2_) (NN manner)) (SBAR (WHNP (WDT that)) (S (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NN malonyl-coenzyme) (NN A)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (VP (VBG affecting) (NP (NP (NN lipid) (NN mobilization)) (PP (IN in) (NP (NN adipose) (NN tissue)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ current) (NNS investigations)))) (VP (VBD was) (VP (VBN focused) (PP (IN on) (NP (NP (DT the) (NN study)) (PP (IN of) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NN lipid) (NN mobilization))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ lipolytic) (NN rate)) (VP (VBD was) (VP (VBN assessed) (PP (IN through) (NP (NN glycerol) (NN release))) (PP (IN after) (NP (NP (NN incubation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN at) (NP (NP (NNS concentrations)) (VP (VBG ranging) (PP (IN from) (NP (NP (NP (NP (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -6)) (-RRB- -RRB-))) (TO to) (NP (CD 10) (PRN (-LRB- -LRB-) (NP (CD -12)) (-RRB- -RRB-)))) (NN M))) (PP (IN in) (NP (NP (VBN isolated) (NNS adipocytes)) (VP (VBN obtained) (PP (IN from) (NP (JJ female) (NNS rats))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NP (JJ equimolar) (NNS concentrations)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NP (CD 10) (-LRB- -LRB-) (CD -12) (-RRB- -RRB-)) (PP (TO to) (NP (CD 10) (-LRB- -LRB-) (CD -6) (-RRB- -RRB-) (NN M)))) (-RRB- -RRB-)))))) (NP (DT the) (VBN observed) (JJ lipolytic) (NN activity)) (VP (VBZ is) (ADJP (JJ comparable) (PP (TO to) (NP (DT the) (JJ basal) (JJ lipolytic) (NN activity)))) (, ,) (PP (IN except) (PP (IN at) (NP (NP (DT a) (NN concentration)) (PP (IN of) (NP (NP (NP (CD 10)) (PRN (-LRB- -LRB-) (NP (NN -9)) (-RRB- -RRB-))) (NN M)))))) (SBAR (WHADVP (WRB where)) (S (PP (IN upon) (NP (NP (DT a) (JJ significant) (NN increase)) (PP (IN in) (NP (NN lipolysis))))) (VP (VBZ is) (VP (VBN observed)))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Summing) (NP (NN up)))) (, ,) (NP (JJ new) (NN evidence)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB interact) (PP (IN in) (NP (DT a) (JJ homeostatic) (NN loop))) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN body-fat) (NN mass)) (CC and) (NP (NN energy) (NN balance))) (PP (CONJP (RB not) (RB only)) (PP (IN at) (NP (NP (DT the) (JJ central) (JJ nervous) (NN system)) (NN level))) (, ,) (CONJP (CC but) (RB also)) (ADVP (RB directly)) (PP (IN at) (NP (DT the) (JJ adipocyte) (NN level)))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Similarly)) (, ,) (NP (JJ central) (NN _PROT1_) (NN treatment)) (ADVP (RB also)) (VP (VBD had) (NP (DT a) (JJR greater) (NN effect)) (PP (IN in) (S (VP (VBG suppressing) (NP (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NN expression)) (PP (IN in) (NP (ADJP (ADJP (JJ young) (PRN (-LRB- -LRB-) (NP (CD -23+/-4) (NN %)) (-RRB- -RRB-))) (CONJP (IN than) (IN in)) (ADJP (JJ old) (PRN (-LRB- -LRB-) (NP (CD -8+/-4) (NN %)) (-RRB- -RRB-)))) (NNS rats)))))) (PP (VBN compared) (PP (IN with) (NP (PRP$ their) (JJ age-matched) (JJ pair-fed) (JJ treated) (NNS rats))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ relative) (NNS risks)) (PP (IN between) (NP (NP (JJS highest) (CC and) (JJS lowest) (NNS quarters)) (PP (IN of) (NP (NP (NN _PROT1_) (NN intake)) (VP (VBN adjusted) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN smoking)) (, ,) (NP (NN serum) (NN _PROT2_) (NN concentration)) (, ,) (NP (NN blood) (NN pressure)) (, ,) (CC and) (NP (NN body) (NN mass) (NN index)))))))))) (VP (VBD were) (NP (NP (NP (CD 0.69)) (PRN (-LRB- -LRB-) (NP (CD 95) (NN %) (NN confidence) (NN interval) (CD 0.53) (TO to) (CD 0.90)) (-RRB- -RRB-))) (CC and) (NP (NP (CD 0.54)) (PRN (-LRB- -LRB-) (NP (CD 0.33) (TO to) (CD 0.87)) (-RRB- -RRB-)))) (PP (IN for) (NP (ADJP (ADJP (JJ total)) (CC and) (ADJP (JJ coronary))) (NN mortality))) (, ,) (ADVP (RB respectively))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Correlation)) (PP (IN between) (NP (NP (DT the) (JJ stimulatory) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (JJ _PROT2_) (NNS _PROT2_)))))))) (CC and) (NP (NP (DT the) (NN oxytocin) (NN receptor) (NN level)) (PP (IN in) (NP (DT the) (JJ pregnant) (NN rabbit) (NN myometrium))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB elucidate) (NP (NP (DT the) (NNS roles)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN oxytocin)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS receptors))) (PP (IN in) (NP (NN rabbit) (NN parturition)))))))) (, ,) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN OT) (NN receptor)) (NP (NNS levels)))))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NN rabbit) (NNS myometria))) (PP (PP (IN before)) (CC and) (PP (IN after) (NP (NN parturition)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB elucidate) (NP (NP (DT the) (NNS roles)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN oxytocin)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS receptors))) (PP (IN in) (NP (NN rabbit) (NN parturition)))))))) (, ,) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN OT) (NN receptor)) (NP (NNS levels)))))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NN rabbit) (NNS myometria))) (PP (PP (IN before)) (CC and) (PP (IN after) (NP (NN parturition)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB elucidate) (NP (NP (DT the) (NNS roles)) (PP (IN of) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN oxytocin)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS receptors))) (PP (IN in) (NP (NN rabbit) (NN parturition)))))))) (, ,) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN OT) (NN receptor)) (NP (NNS levels)))))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NN rabbit) (NNS myometria))) (PP (PP (IN before)) (CC and) (PP (IN after) (NP (NN parturition)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (NN _PROT2_) (NN formation)) (CC and) (NP (NN OT) (NN receptor) (NNS levels))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NP (DT the) (NNS myometria)) (PP (IN of) (NP (NP (JJ non-pregnant) (NNS rabbits)) (, ,) (NP (NP (NP (NNS Days) (CD 26)) (, ,) (NP (CD 28)) (CC and) (NP (CD 30))) (PP (IN of) (NP (NN pregnancy) (NNS rabbits)))) (, ,) (NP (NP (JJ postpartum) (NNS rabbits)) (PP (IN within) (NP (CD 12) (NNS hours)))) (CC and) (NP (JJ steroid-treated) (JJ ovariectomized) (NNS rabbits)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (S (NP (NN OT) (NNS receptors)) (VP (VBD were) (RB not) (ADJP (JJ detectable) (PP (IN in) (NP (NP (DT the) (NNS myometria)) (PP (IN of) (NP (JJ non-pregnant) (NNS rabbits)))))))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (JJ _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IPs)) (-RRB- -RRB-)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN On) (NP (NP (NN Day) (CD 28)) (PP (IN of) (NP (NN pregnancy))))) (, ,) (S (S (NP (NN OT) (NNS receptors)) (VP (VBD became) (ADJP (JJ detectable)))) (, ,) (CC and) (S (ADVP (RB then)) (NP (NN _PROT1_)) (VP (MD could) (VP (VB induce) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NNS _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thereafter)) (, ,) (NP (NP (NP (DT the) (JJ stimulatory) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN _PROT2_) (NN formation)))) (CC and) (NP (DT the) (NN OT) (NN receptor) (NNS levels))) (ADVP (RB dramatically)) (VP (VP (VBD increased) (PP (IN toward) (NP (NP (DT the) (NN end)) (PP (IN of) (NP (NN pregnancy)))))) (CC and) (VP (VBD reduced) (ADVP (RB rapidly)) (PP (IN after) (NP (NN parturition))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT the) (JJ ovariectomized) (JJ pregnant) (NNS rabbits)) (VP (VBD were) (VP (VBN treated) (PP (IN with) (NP (NN estrogen))))))) (, ,) (S (S (NP (NP (NN OT) (NNS receptors)) (PP (IN in) (NP (DT the) (NN myometrium)))) (VP (VBD were) (VP (VBN induced)))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD acquired) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB stimulate) (NP (NN _PROT2_) (NN formation))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (DT an) (JJ OT) (NN receptor) (NN antagonist)) (VP (VBD inhibited) (NP (NP (DT the) (JJ stimulatory) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN _PROT2_) (NN formation))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT the) (NN OT) (NN receptor) (NNS levels)) (PP (IN in) (NP (DT the) (NN myometrium)))) (, ,) (CC and) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NN PGF2))) (PP (IN in) (NP (DT the) (NN decidua))))))) (VP (MD might) (VP (VB play) (NP (JJ crucial) (NNS roles)) (PP (IN in) (NP (NN parturition)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBZ upregulates) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-2)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (NP (NNS islets)) (PP (IN of) (NP (JJ normal) (NNS rats))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (NN effect)) (PP (IN in) (NP (NP (NNS islets)) (PP (IN of) (NP (JJ obese) (NN Zucker) (JJ Diabetic) (NN Fatty) (-LRB- -LRB-) (NN ZDF) (-RRB- -RRB-) (NNS rats))) (PP (IN with) (NP (VBN mutated) (NN leptin) (NNS receptors))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN 5-HT3) (JJ serotonergic) (NNS receptors))) (PP (IN with) (NP (NP (NN ondansetron)) (PRN (-LRB- -LRB-) (NP (QP (CD 4) (CC or) (CD 8)) (NN mg)) (-RRB- -RRB-))))) (VP (VBD did) (RB not) (VP (VB modify) (NP (NP (NP (DT the) (JJ basal) (NN secretion)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (DT the) (JJ _PROT2_) (NN response)) (PP (TO to) (NP (JJ _PROT_) (NN hypoglycemia))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN 5-HT3) (JJ serotonergic) (NNS receptors))) (PP (IN with) (NP (NP (NN ondansetron)) (PRN (-LRB- -LRB-) (NP (QP (CD 4) (CC or) (CD 8)) (NN mg)) (-RRB- -RRB-))))) (VP (VBD did) (RB not) (VP (VB modify) (NP (NP (NP (DT the) (JJ basal) (NN secretion)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (DT the) (JJ _PROT_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN 5-HT3) (JJ serotonergic) (NNS receptors))) (PP (IN with) (NP (NP (NN ondansetron)) (PRN (-LRB- -LRB-) (NP (QP (CD 4) (CC or) (CD 8)) (NN mg)) (-RRB- -RRB-))))) (VP (VBD did) (RB not) (VP (VB modify) (NP (NP (NP (DT the) (JJ basal) (NN secretion)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB explore) (NP (NP (DT the) (JJ possible) (NNS roles)) (PP (IN of) (NP (DT the) (JJ hypothalamic) (NN melanocortin) (NN system))) (PP (IN in) (NP (NN _PROT1_) (NN action))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ intracerebroventricular)) (PRN (-LRB- -LRB-) (NP (NN i.c.v.)) (-RRB- -RRB-))) (NN injection)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (CC or) (PP (IN without) (NP (NP (NN SHU9119)) (, ,) (NP (NP (DT a) (JJ potent) (NN antagonist)) (PP (IN of) (NP (JJ alpha-melanocyte) (NN stimulating) (NN hormone)))) (, ,)))))) (PP (IN on) (NP (NP (NP (NN food) (NN intake)) (, ,) (NP (NN body) (NN weight)) (, ,) (CC and) (NP (NP (JJ mitochondrial) (VBG _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-1)) (-RRB- -RRB-))) (NP (NN mRNA) (NN expression))) (PP (IN in) (NP (NP (DT the) (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-)))) (PP (IN in) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB explore) (NP (NP (DT the) (JJ possible) (NNS roles)) (PP (IN of) (NP (DT the) (JJ hypothalamic) (NN melanocortin) (NN system))) (PP (IN in) (NP (NN _PROT1_) (NN action))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ intracerebroventricular)) (PRN (-LRB- -LRB-) (NP (NN i.c.v.)) (-RRB- -RRB-))) (NN injection)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (CC or) (PP (IN without) (NP (NP (NN SHU9119)) (, ,) (NP (NP (DT a) (JJ potent) (NN antagonist)) (PP (IN of) (NP (JJ alpha-melanocyte) (NN stimulating) (NN hormone)))) (, ,)))))) (PP (IN on) (NP (NP (NP (NN food) (NN intake)) (, ,) (NP (NN body) (NN weight)) (, ,) (CC and) (NP (NP (JJ mitochondrial) (VBG _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-1)) (-RRB- -RRB-))) (NP (NN mRNA) (NN expression))) (PP (IN in) (NP (NP (DT the) (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-)))) (PP (IN in) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB explore) (NP (NP (DT the) (JJ possible) (NNS roles)) (PP (IN of) (NP (DT the) (JJ hypothalamic) (NN melanocortin) (NN system))) (PP (IN in) (NP (NN _PROT_) (NN action))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ intracerebroventricular)) (PRN (-LRB- -LRB-) (NP (NN i.c.v.)) (-RRB- -RRB-))) (NN injection)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (CC or) (PP (IN without) (NP (NP (NN SHU9119)) (, ,) (NP (NP (DT a) (JJ potent) (NN antagonist)) (PP (IN of) (NP (JJ alpha-melanocyte) (NN stimulating) (NN hormone)))) (, ,)))))) (PP (IN on) (NP (NP (NP (NN food) (NN intake)) (, ,) (NP (NN body) (NN weight)) (, ,) (CC and) (NP (NP (JJ mitochondrial) (VBG _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-1)) (-RRB- -RRB-))) (NP (NN mRNA) (NN expression))) (PP (IN in) (NP (NP (DT the) (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-)))) (PP (IN in) (NP (NNS rats)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ single) (NN i.c.v.) (NN injection)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD decreased) (NP (NP (JJ cumulative) (NN food) (NN intake)) (CC and) (NP (NN body) (NN weight) (NN gain)) (, ,) (CC and) (NP (VBN increased) (NN _PROT2_) (NN mRNA) (NN expression))) (PP (IN during) (NP (CD 3) (NN h))) (PP (IN at) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (DT the) (NN dark) (NN phase)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Co-injection)) (PP (IN of) (NP (NN SHU9119)))) (ADVP (RB also)) (VP (VBD inhibited) (ADVP (RB completely)) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN mRNA) (NN expression))) (PP (IN in) (NP (DT the) (NN BAT))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN established) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN beta) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN AbetaP)) (-RRB- -RRB-))) (VP (VBZ activates) (NP (NP (NP (NN phospholipase) (NN A2)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN phospholipase) (NN D))) (PP (IN of) (NP (NP (NN LA-N-2) (NNS cells)) (CC and) (NP (JJ other) (NN cell) (NNS types))))))))))))) |ET|
+1 |BT| (S1 (S (NP (-LRB- -LRB-) (TO -) (-RRB- -RRB-) (NN Nicotine)) (VP (VBD did) (RB not) (VP (VB blunt) (NP (NP (DT the) (NN _PROT1_) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ specific) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN PKC) (-RRB- -RRB-) (NN inhibitor) (NN chelerythrine)) (PRN (-LRB- -LRB-) (NP (CD 5) (NNS micrometers)) (-RRB- -RRB-))) (VP (VBD inhibited) (NP (NP (NN PTH-)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN PGE2-)) (, ,) (CC and) (NP (JJ adenosine-stimulated) (NN Ca2+) (NN reabsorption))) (PP (IN by) (NP (NP (CD 77) (NN %)) (, ,) (NP (CD 67) (NN %)) (, ,) (NP (CD 79) (NN %)) (, ,) (CC and) (NP (CD 100) (NN %)))))) (, ,) (RB respectively))) |ET|
+1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NP (NN PTH)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN PGE2)) (, ,) (CC and) (NP (NN adenosine))) (VP (VBP stimulate) (NP (NN Ca2+) (NN reabsorption)) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ independent) (PP (IN of) (NP (NN cAMP))))))) (CC and) (SBAR (WHNP (WDT that)) (S (VP (VBZ involves) (NP (DT a) (ADJP (NN phorbol) (JJ ester-insensitive)) (NN _PROT2_) (NN isotype))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS experiments)) (VP (VBD were) (VP (VBN concluded) (PP (IN by) (S (VP (VBG taking) (NP (NP (NP (NN blood) (NNS samples)) (PP (IN for) (NP (NP (JJ later) (NN analysis)) (PP (IN of) (NP (NN plasma) (NN glucose)))))) (CC and) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (DT the) (JJ following) (NNS hormones)) (: :) (NP (NP (NN _PROT1_)) (, ,) (NP (NN gastrin)) (, ,) (NP (NN CCK)) (, ,) (NP (NN glucagon)) (, ,) (NP (NN somatostatin)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN corticosterone)))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ low-performing) (NN Stock) (NN B) (NNS animals)) (VP (VBD were) (VP (VBN characterized) (PP (IN by) (S (NP (NN [1) (-RRB- -RSB-)) (VP (VBG being) (ADJP (RBR more) (JJ reactive) (PP (TO to) (NP (JJ sensory) (NN stimulation)))))))))) (: :) (NP (NP (JJR higher) (NN startle) (NN amplitude)) (CC and) (NP (JJR shorter) (NN startle) (NN latency))) (: ;) (NP (NP (NP (CD [2) (-RRB- -RSB-)) (VP (VBG having) (NP (NP (NP (JJR higher) (NN plasma) (NN _PROT1_)) (CC and) (NP (NN corticosterone))) (NNS levels)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN plasma) (NN gastrin)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB significantly)) (VP (VBN lowered))))))) (CC and) (NP (NP (DT a) (JJ strong) (NN tendency)) (PP (IN for) (NP (NP (DT a) (NN decrease)) (PP (ADVP (RB also)) (IN in) (NP (NN plasma) (NN CCK))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NP (NN G11alpha)) (CC and) (NP (NP (NNS isoforms)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))))) (PP (IN in) (NP (NN islet) (NNS beta-cells)))) (VP (VBZ reveals) (NP (NP (DT a) (NN lack)) (PP (IN of) (NP (NP (NN correlation)) (PP (IN between) (NP (NP (NN inositol) (NN phosphate) (NN accumulation)) (CC and) (NP (NN _PROT2_) (NN secretion))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN suggested) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN secretion)) (PP (IN from) (NP (JJ pancreatic) (NNS islets)))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NP (NN activation)) (PP (IN of) (NP (NNS _PROT2_) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLCs)) (-RRB- -RRB-))) (CC and) (NP (JJ phosphoinositide) (NN hydrolysis)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN purpose)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (ADJP (RB relatively) (JJ modest)) (JJ fuel-stimulated) (NN _PROT1_) (NN secretion) (NNS responses)) (PP (IN of) (NP (JJ rodent) (NN beta-cell) (NNS lines)))) (VP (MD might) (VP (VB be) (VP (VBN explained) (PP (IN by) (NP (NP (JJ inadequate) (NP (NN expression)) (CC or) (NP (NN activation))) (PP (IN of) (NP (NN _PROT2_) (NNS isoforms))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Adenovirus-mediated) (NN overexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN -beta1)) (, ,) (CC or) (NP (NN -beta3)))) (PP (IN in) (NP (NN INS-1) (CC or) (NN betaG) (NN 40/110) (NNS cells)))) (VP (VBZ results) (PP (IN in) (NP (NP (ADJP (JJ little))) (CC or) (NP (NP (DT no) (NN enhancement)) (PP (IN in) (NP (NP (JJ inositol) (NN phosphate) (-LRB- -LRB-) (NN IP) (-RRB- -RRB-) (NN accumulation)) (CC and) (NP (NP (DT no) (NN improvement)) (PP (IN in) (NP (NN _PROT2_) (NN secretion))))))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NNS cells)) (VP (VBP are) (VP (VBN stimulated) (PP (IN with) (NP (NP (NN glucose)) (CC or) (NP (NN carbachol)))))))) (, ,) (PP (IN despite) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (VBN overexpressed) (NNS proteins)) (VP (VBP are) (ADJP (RB fully) (JJ active) (PP (IN in) (NP (NN cell) (NNS extracts))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN -beta3)))) (PP (IN in) (NP (JJ normal) (NN rat) (NNS islets)))) (VP (VP (VBZ elicits) (NP (NP (DT a) (JJR larger) (NN increase)) (PP (IN in) (NP (NN IP) (NN accumulation))))) (CC but) (, ,) (ADVP (RB again)) (, ,) (VP (VBZ has) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN _PROT2_) (NN secretion)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN carbachol))) (PP (IN on) (NP (NN _PROT1_) (NN secretion)))) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN through) (NP (NP (JJ muscarinic) (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP link) (PP (TO to) (NP (NP (DT the) (NN Gq/11) (NN class)) (PP (IN of) (NP (JJ heterotrimeric) (NN G) (NNS proteins)))))))))))))))))) (, ,) (NP (PRP we)) (ADVP (RB also)) (VP (VBD overexpressed) (NP (NP (NN G11alpha)) (PP (IN in) (NP (NN INS-1) (NNS cells))) (, ,) (UCP (CC either) (ADVP (RB alone)) (CC or) (PP (IN in) (NP (NP (NN concert)) (PP (IN with) (NP (NP (NN overexpression)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN -beta3)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN G11alpha)))) (VP (VBZ enhances) (NP (NP (NN IP) (NN accumulation)) (, ,) (NP (NP (DT an) (NN effect)) (VP (ADVP (RB slightly)) (VBN potentiated) (PP (IN by) (NP (NP (NN co-overexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN -beta3))))))))))) (, ,) (CC but) (S (NP (DT these) (NNS maneuvers)) (VP (VBP do) (RB not) (VP (VB affect) (NP (NP (NN glucose)) (CC or) (NP (JJ carbachol-stimulated) (NN _PROT2_) (NN secretion))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT2_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT2_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT1_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT1_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT1_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT_) (NNS levels)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT_) (NNS levels)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT2_) (NNS levels)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT_) (NNS levels)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT2_) (NNS levels)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT2_) (NNS levels)))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (VBN isolated) (JJ white) (NNS adipocytes))) (, ,) (NP (DT the) (VBN released) (NN adenosine)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NP (NN helper)) (CC and/or) (NP (NP (DT a) (JJ positive) (NN regulator)) (PP (IN for) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN leptin)))))))) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NP (NN adenosine) (NN A1) (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBZ involves) (NP (DT the) (JJ _PROT2_) (NN pathway)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ lysophosphatidic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN LPA)) (-RRB- -RRB-)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (CC and) (NP (JJ mitogen-activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NNS kinases))) (CC and) (NP (NP (DT the) (NN proliferation)) (PP (IN of) (NP (JJ vascular) (JJ smooth) (NN muscle) (NNS cells))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NP (JJ _PROT1_) (NN activation)) (PP (IN of) (NP (NP (NN RSK2)) (, ,) (NP (NP (DT a) (JJ downstream) (NN substrate)) (PP (IN of) (NP (NP (NN ERK1)) (CC and) (NP (NN ERK2))))) (, ,)))) (VP (VBD was) (UCP (ADJP (JJ _PROT2_)) (CC and) (NP (NN PI) (NN 3-kinase-independent)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD was) (ADJP (JJ necessary)) (PP (PP (IN in) (NP (NN _PROT2_))) (CC but) (PP (RB not) (IN in) (NP (NP (JJ LPA-induced) (NN activation)) (PP (IN of) (NP (NN p70) (NN S6K))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (JJ central) (NNS injections)) (PP (TO to) (NP (JJ intact) (NNS animals)))) (VP (VBD stimulated) (NP (NP (NN _PROT2_) (NN synthesis)) (CC and) (NP (NN secretion))) (PP (IN without) (S (VP (VBG changing) (PP (IN of) (NP (NNS islets) (NN area))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (S (S (NP (NN _PROT1_) (NN administration)) (VP (VBZ stimulates) (NP (NP (NP (NN _PROT2_) (NN synthesis)) (CC and) (NP (NN secretion))) (PP (IN in) (NP (ADJP (ADJP (JJ intact)) (CC and) (ADJP (JJ diabetic))) (NNS animals)))))) (CC and) (S (NP (DT this) (NN effect)) (VP (VBZ is) (ADVP (RBR more)) (VP (VBN expressed) (PP (IN with) (NP (JJ central) (NNS injections))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD reported) (SBAR (SBAR (IN that) (S (NP (NP (NN adiposity)) (CC and) (NP (NN serum) (NN _PROT1_) (NNS levels))) (VP (VBP increase) (PP (IN with) (NP (NN age))) (PP (IN in) (NP (JJ male) (NN F-344xBN) (NNS rats)))))) (CC and) (SBAR (IN that) (S (SBAR (WHADVP (WRB when)) (S (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (NN serum) (NN _PROT2_)))) (VP (VBP are) (VP (VBN manipulated) (PP (IN by) (NP (NN fasting))))))) (, ,) (S (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ corresponding) (JJ reciprocal) (NN change)) (PP (IN in) (NP (NP (NP (JJ hypothalamic) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (JJ young) (NNS rats)))))) (, ,) (CC but) (S (NP (EX there)) (VP (VBP are) (NP (NP (DT no) (NNS changes)) (PP (IN in) (NP (JJR older) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD reported) (SBAR (SBAR (IN that) (S (NP (NP (NN adiposity)) (CC and) (NP (NN serum) (NN _PROT1_) (NNS levels))) (VP (VBP increase) (PP (IN with) (NP (NN age))) (PP (IN in) (NP (JJ male) (NN F-344xBN) (NNS rats)))))) (CC and) (SBAR (IN that) (S (SBAR (WHADVP (WRB when)) (S (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (NN serum) (NN _PROT_)))) (VP (VBP are) (VP (VBN manipulated) (PP (IN by) (NP (NN fasting))))))) (, ,) (S (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ corresponding) (JJ reciprocal) (NN change)) (PP (IN in) (NP (NP (NP (JJ hypothalamic) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (JJ young) (NNS rats)))))) (, ,) (CC but) (S (NP (EX there)) (VP (VBP are) (NP (NP (DT no) (NNS changes)) (PP (IN in) (NP (JJR older) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD reported) (SBAR (SBAR (IN that) (S (NP (NP (NN adiposity)) (CC and) (NP (NN serum) (NN _PROT_) (NNS levels))) (VP (VBP increase) (PP (IN with) (NP (NN age))) (PP (IN in) (NP (JJ male) (NN F-344xBN) (NNS rats)))))) (CC and) (SBAR (IN that) (S (SBAR (WHADVP (WRB when)) (S (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (NN serum) (NN _PROT1_)))) (VP (VBP are) (VP (VBN manipulated) (PP (IN by) (NP (NN fasting))))))) (, ,) (S (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ corresponding) (JJ reciprocal) (NN change)) (PP (IN in) (NP (NP (NP (JJ hypothalamic) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (JJ young) (NNS rats)))))) (, ,) (CC but) (S (NP (EX there)) (VP (VBP are) (NP (NP (DT no) (NNS changes)) (PP (IN in) (NP (JJR older) (NNS rats))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (JJ hypothalamic) (NN _PROT1_) (NN mRNA))) (PP (IN by) (NP (NN _PROT2_)))) (VP (MD may) (VP (VB be) (VP (VBN impaired) (PP (IN with) (NP (NN age))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NP (JJ daily) (NN food) (NN consumption)) (, ,) (NP (NN body) (NN weight)) (, ,) (NP (NN whole-body) (NN oxygen) (NN consumption)) (, ,) (NP (NN serum) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN mRNA))) (PP (IN in) (NP (DT the) (NN hypothalamus))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN infusion)) (VP (VBD diminished) (NP (JJ hypothalamic) (NN _PROT2_) (NNS levels)) (PP (IN by) (NP (QP (RB nearly) (CD 50)) (NN %))) (PP (VBN compared) (PP (IN with) (NP (JJ pair-fed) (JJ young) (NNS rats)))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD were) (NP (DT no) (NNS changes)) (PP (IN in) (NP (NP (DT the) (JJ hypothalamic) (NN _PROT_) (NN mRNA) (NNS levels)) (PP (IN in) (NP (JJ senescent) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN infusion)) (VP (VBD diminished) (NP (JJ hypothalamic) (NN _PROT_) (NNS levels)) (PP (IN by) (NP (QP (RB nearly) (CD 50)) (NN %))) (PP (VBN compared) (PP (IN with) (NP (JJ pair-fed) (JJ young) (NNS rats)))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD were) (NP (DT no) (NNS changes)) (PP (IN in) (NP (NP (DT the) (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NNS levels)) (PP (IN in) (NP (JJ senescent) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN infusion)) (VP (VBD diminished) (NP (JJ hypothalamic) (NN _PROT1_) (NNS levels)) (PP (IN by) (NP (QP (RB nearly) (CD 50)) (NN %))) (PP (VBN compared) (PP (IN with) (NP (JJ pair-fed) (JJ young) (NNS rats)))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD were) (NP (DT no) (NNS changes)) (PP (IN in) (NP (NP (DT the) (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NNS levels)) (PP (IN in) (NP (JJ senescent) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT These) (VBN diminished) (NNS responses)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBD were) (VP (VBN associated) (PP (IN with)))) (CC and) (VP (MD may) (VP (VB be) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (DT an) (JJ impaired) (NN suppression)) (PP (IN of) (NP (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NNS levels))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ specific) (NN inhibitor) (CD Go-6983)) (ADVP (RB further)) (VP (VBD enhanced) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (NN VACM-1))) (PP (IN on) (NP (JJ _PROT2_) (NN cAMP) (NN production))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN infusion))) (PP (IN on) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN expression)) (PP (IN in) (NP (NN rat) (NN muscle)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT1_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT1_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT1_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB substantiate) (NP (NP (DT an) (NN involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN muscle) (NN _PROT2_) (NN expression))))))))) (, ,) (S (NP (JJ hypothyroid) (NNS rats)) (VP (VBD were) (ADVP (RB ICV)) (VP (VBN infused) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (NN vehicle))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB substantiate) (NP (NP (DT an) (NN involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN muscle) (NN _PROT_) (NN expression))))))))) (, ,) (S (NP (JJ hypothyroid) (NNS rats)) (VP (VBD were) (ADVP (RB ICV)) (VP (VBN infused) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (NN vehicle))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB substantiate) (NP (NP (DT an) (NN involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (NN muscle) (NN _PROT1_) (NN expression))))))))) (, ,) (S (NP (JJ hypothyroid) (NNS rats)) (VP (VBD were) (ADVP (RB ICV)) (VP (VBN infused) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (NN vehicle))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (PP (IN in) (NP (JJ hypothyroid) (NNS rats))) (, ,) (NP (NN ICV) (NN _PROT1_)) (VP (VBD was) (ADJP (JJ unable) (S (VP (TO to) (VP (VB maintain) (NP (NN muscle) (NN _PROT2_) (NN expression)) (PP (IN at) (NP (NP (NNS values)) (VP (VBN measured) (PP (IN in) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (JJ central) (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN T3) (NN production)) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NN T4))) (PP (TO to) (NP (NN T3) (NN conversion)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (DT this) (NN stimulation)) (VP (MD could) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN on) (NP (NN muscle) (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (JJ central) (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN T3) (NN production)) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NN T4))) (PP (TO to) (NP (NN T3) (NN conversion)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (DT this) (NN stimulation)) (VP (MD could) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (NN muscle) (NN _PROT2_) (NN expression)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (JJ central) (NN _PROT_)) (VP (VBZ stimulates) (NP (NN T3) (NN production)) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NN T4))) (PP (TO to) (NP (NN T3) (NN conversion)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (DT this) (NN stimulation)) (VP (MD could) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN muscle) (NN _PROT2_) (NN expression)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (JJ adult) (NNS rats)))) (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (VP (VBN exerted) (PP (IN at) (NP (JJ hypothalamic) (NN level))) (PP (IN by) (S (VP (VBG regulating) (NP (NP (NP (NP (NN growth) (NN hormone) (VBG releasing) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN GHRH)) (-RRB- -RRB-))) (, ,) (NP (NN somatostatin)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-)))) (VP (VBG -producing) (NP (NNS neurones)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN secretion)) (, ,) (NP (NN inositol) (NN phosphate) (NNS levels)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS isozymes))) (PP (IN in) (NP (JJ rodent) (JJ pancreatic) (NNS islets)))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (NN concept)) (SBAR (IN that) (S (NP (NP (DT the) (NN underexpression)) (PP (IN of) (NP (DT the) (JJ nutrient-activated) (NN _PROT1_) (NN isozyme)))) (VP (MD may) (VP (VB account) (PP (IN for) (NP (NP (NP (DT the) (JJ minimal) (NN inositol) (NN phosphate)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (CC and) (NP (NN second-phase) (NN _PROT2_) (JJ secretory) (NN response)))) (PP (IN from) (NP (NN mouse) (NNS islets))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN Gibbestatin) (NN B)) (VP (VBZ inhibits) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NN expression))) (PP (IN in) (NP (JJ cereal) (NN seeds) (NN [In) (NN Process)))))) (S (NP (NNP Citation)) (-RRB- -RSB-)))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (JJ aleurone) (NNS layers)) (PP (IN of) (NP (NN barley)))))) (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN GA)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (NP (NN gibbestatin) (NN B)) (PRN (-LRB- -LRB-) (NP (NN GNB)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN isolated) (PP (IN from) (NP (ADJP (FW Streptomyces) (FW sp.)) (NN C-39))) (PP (IN as) (NP (NP (DT an) (NN inhibitor)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NN barley)) (CC and) (NP (NN rice)))))))))) (, ,) (PP (IN with) (NP (NP (NN IC50) (NNS values)) (PP (IN of) (NP (QP (CD 125) (CC and) (CD 70)) (NN microM))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN GNB)) (VP (VBD suppressed) (NP (NP (NN accumulation)) (PP (IN of) (NP (NP (NP (JJ _PROT1_) (NN barley) (NN high-pI) (NN type) (NN B)) (CC and) (NP (NN rice) (NN RAmylA) (NN _PROT2_))) (NNS transcripts)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN GNB)) (VP (VBZ inhibits) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_)))) (PP (PP (IN by) (S (VP (VBG regulating) (NP (NP (CD one)) (PP (IN of) (NP (NP (DT the) (NNS steps)) (VP (VBN involved) (PP (IN in) (NP (NN ABA) (NN signaling)))))))))) (, ,) (CC but) (PP (RB not) (IN by) (S (VP (VBG acting) (PP (IN as) (NP (DT a) (JJ weak) (NN ABA) (NN analog)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NP (JJ _PROT1_) (NN phospholipase) (NN D1)) (CC and) (NP (NN phospholipase) (NN D2))) (NN activity)) (PP (IN in) (NP (JJ human) (JJ embryonic) (NN kidney-293) (NNS cells)))) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN protein) (NN kinase) (NN Calpha) (NN signalling) (NN cascade)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (NN PLD1))) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))) (VP (VBZ has) (NP (DT the) (JJ same) (NN effect)) (, ,) (SBAR (IN while) (S (NP (NP (NN co-expression)) (PP (IN of) (NP (NN PLD2))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ allows) (NP (NN PLD2) (NN activity)) (S (VP (TO to) (VP (VB be) (VP (VBN stimulated) (PP (IN in) (NP (DT an) (JJ _PROT_) (NN manner)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (NN PLD1))) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))) (VP (VBZ has) (NP (DT the) (JJ same) (NN effect)) (, ,) (SBAR (IN while) (S (NP (NP (NN co-expression)) (PP (IN of) (NP (NN PLD2))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ allows) (NP (NN PLD2) (NN activity)) (S (VP (TO to) (VP (VB be) (VP (VBN stimulated) (PP (IN in) (NP (DT an) (JJ _PROT2_) (NN manner)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (NN PLD1))) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VBZ has) (NP (DT the) (JJ same) (NN effect)) (, ,) (SBAR (IN while) (S (NP (NP (NN co-expression)) (PP (IN of) (NP (NN PLD2))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ allows) (NP (NN PLD2) (NN activity)) (S (VP (TO to) (VP (VB be) (VP (VBN stimulated) (PP (IN in) (NP (DT an) (JJ _PROT2_) (NN manner)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ PKC-specific) (NNS inhibitors)) (NP (NP (NN bisindolylmaleimide)) (CC and) (NP (VB Go) (NN 6976)))) (VP (VBP abolish) (NP (JJ _PROT1_) (NN PLD2) (NN activation)) (PP (IN in) (NP (NP (NN HEK-293) (NNS cells)) (VP (VBG co-expressing) (NP (NP (DT the) (NN insulin) (NN receptor)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN PLD2))))))) (, ,) (S (VP (VBG confirming) (SBAR (IN that) (S (NP (RB not) (RB only) (NP (NN PLD1)) (, ,) (CC but) (NP (NP (NN PLD2)) (ADVP (RB as) (RB well))) (, ,)) (VP (VBZ is) (VP (VBN regulated) (PP (IN in) (NP (DT a) (JJ PKC-dependent) (NN manner))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_) (NN treatment)) (VP (VBZ results) (PP (IN in) (NP (NP (NN activation)) (PP (IN of) (NP (CC both) (NP (NN PLD1)) (CC and) (NP (NN PLD2)))) (PP (IN in) (NP (JJ appropriate) (NN cell) (NNS types))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (DT the) (JJ appropriate) (JJ upstream) (NN intermediate) (NN signalling) (NNS components)) (, ,) (PP (FW i.e.) (NP (NP (NN PKCalpha)) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP are) (VP (VBN expressed) (PP (IN at) (NP (JJ sufficient) (NNS levels))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Hesperidin)) (, ,) (NP (NP (DT the) (ADJP (RBS most) (JJ important)) (NN _PROT1_)) (PP (IN of) (NP (NN Citrus) (CD sp.)))) (, ,)) (ADVP (RB significantly)) (VP (VP (VBZ increases) (NP (NN HDL))) (CC and) (VP (VBZ lowers) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN LDL)) (, ,) (NP (JJ total) (NN lipid)) (CC and) (NP (NN triglyceride) (NN plasma) (NNS levels))) (PP (PP (IN in) (NP (JJ normolipidemic) (NNS rats))) (CC and) (PP (IN in) (NP (NP (NNS rats)) (PP (IN with) (NP (ADJP (ADJP (JJ diet-)) (CC and) (ADJP (JJ triton-induced))) (NN hyperlipidemia))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN hCG)) (, ,) (NP (NN hCG)) (CC plus) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN on) (NP (NP (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NNS formations)) (PP (IN in) (NP (NP (NN porcine) (NN myometrial) (NNS cells)) (VP (VBN obtained) (PP (IN from) (NP (ADJP (ADJP (JJ ovariectomized)) (CC and) (ADJP (JJ cyclic))) (NNS gilts))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN hCG)) (, ,) (NP (NN hCG)) (CC plus) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (PP (IN on) (NP (NP (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NNS formations)) (PP (IN in) (NP (NP (NN porcine) (NN myometrial) (NNS cells)) (VP (VBN obtained) (PP (IN from) (NP (ADJP (ADJP (JJ ovariectomized)) (CC and) (ADJP (JJ cyclic))) (NNS gilts))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN hCG)) (, ,) (NP (NN hCG)) (CC plus) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (PP (IN on) (NP (NP (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NNS formations)) (PP (IN in) (NP (NP (NN porcine) (NN myometrial) (NNS cells)) (VP (VBN obtained) (PP (IN from) (NP (ADJP (ADJP (JJ ovariectomized)) (CC and) (ADJP (JJ cyclic))) (NNS gilts))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJS highest) (NN production)) (PP (IN of) (NP (NP (JJ total) (NN _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN d.p.m.)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (PP (IN from) (NP (NP (JJ ovariectomized) (NNS gilts)) (VP (VP (VBN given) (NP (NP (ADJP (FW in) (FW vivo)) (NN estradiol) (NN benzoate)) (CC and) (NP (NN progesterone))) (PP (IN for) (NP (CD five) (JJ consecutive) (NNS days)))) (CC and) (VP (VBN treated) (PP (IN with) (NP (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC and) (NP (ADJP (CD 100) (NN mU)) (NN hCG))) (CC plus) (NP (NP (ADJP (CD 1) (NN microM)) (NN _PROT2_)) (PRN (-LRB- -LRB-) (QP (QP (CD 984) (CC +/-) (CD 84) (CC and) (CD 1063)) (CC +/-) (QP (QP (CD 131) (CC vs) (CD 314) (CC +/-) (CD 36)) (, ,))) (ADVP (RB respectively)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
-1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
-1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (RB Only) (NN _PROT1_)) (ADVP (RB alone)) (VP (VBD increased) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (NNS cells)) (PP (IN from) (NP (NP (JJ ovariectomized) (NNS pigs)) (VP (VBN treated) (PP (IN with) (NP (NN estradiol))) (ADVP (FW in) (FW vivo))))))) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.01)) (-RRB- -RRB-))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT The) (JJS highest) (NN dose)) (PP (IN of) (NP (NN hCG)))) (CC plus) (NP (NP (DT The) (JJS highest) (NN dose)) (PP (IN of) (NP (NP (NN hCG)) (CC plus) (NP (NN _PROT1_)))))) (VP (VBD provoked) (NP (NP (NN accumulation)) (PP (IN of) (NP (NN total) (LST (LS [3H) (-RRB- -RSB-)) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))) (NP (CD 53) (NN %))))) (PP (IN over) (NP (DT the) (JJ basal) (NN level))) (PP (IN on) (NP (NP (NNS days) (NP (CD 21/1))) (PP (IN of) (NP (DT the) (NN estrous) (NN cycle)))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (NN hCG)) (CC and) (NP (NN _PROT1_))) (VP (MD can) (VP (VB increase) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (JJ _PROT2_) (NNS _PROT2_))) (PP (IN in) (NP (NN porcine) (NN myometrial) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN HVSMC))) (S (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN AVP))) (VP (VBD increased) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN production)) (CC and) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (NN response))))) (, ,) (CC but) (S (NP (NP (DT the) (NN efficacy)) (PP (IN of) (NP (DT the) (NNS responses)))) (VP (VBD was) (ADJP (ADJP (JJR greater)) (PP (IN for) (NP (NN _PROT_))) (PP (IN than) (NP (NN AVP))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN HVSMC))) (S (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN AVP))) (VP (VBD increased) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN production)) (CC and) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (NN response))))) (, ,) (CC but) (S (NP (NP (DT the) (NN efficacy)) (PP (IN of) (NP (DT the) (NNS responses)))) (VP (VBD was) (ADJP (ADJP (JJR greater)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN than) (NP (NN AVP))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN HVSMC))) (S (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN AVP))) (VP (VBD increased) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN production)) (CC and) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (NN response))))) (, ,) (CC but) (S (NP (NP (DT the) (NN efficacy)) (PP (IN of) (NP (DT the) (NNS responses)))) (VP (VBD was) (ADJP (ADJP (JJR greater)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN than) (NP (NN AVP))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Gamma-aminobutyric) (NN acid) (NN mediation)) (PP (IN of) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (JJ nitric) (NN oxide))) (PP (IN on) (NP (NP (DT the) (NP (NP (NN arginine) (NN vasopressin)) (CC and) (NP (NN _PROT1_))) (NNS responses)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (SBAR (IN that) (S (NP (DT the) (NP (NP (JJ nitric) (NN oxide)) (PRN (-LRB- -LRB-) (NP (NN NO)) (-RRB- -RRB-))) (NN synthase) (NN inhibitor) (NN L-NAME)) (VP (VBZ exerts) (NP (JJ positive) (NNS effects)) (PP (IN on) (NP (NP (DT the) (NP (NP (NP (NN arginine) (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS responses)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))))) (, ,) (S (VP (VBG suggesting) (NP (NP (JJ inhibitory) (NNS actions)) (PP (IN of) (NP (NN NO))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNP AVP)) (CC and) (NP (NNP _PROT1_))) (JJ secretory) (NNS patterns)) (PP (IN during) (NP (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN 0.15) (NN IU/kg)) (, ,) (NP (NN i.v.))) (-RRB- -RRB-))) (NN -tolerance) (NNS tests)) (PRN (-LRB- -LRB-) (NP (NN ITT)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN examined) (PP (IN in) (NP (NP (CD seven) (JJ normal) (JJ male) (NNS subjects)) (PP (PP (IN with) (S (PRN (-LRB- -LRB-) (NP (JJ experimental) (NNS tests)) (-RRB- -RRB-)))) (CC and) (PP (IN without) (NP (NP (PRN (-LRB- -LRB-) (NP (NN control) (NN test)) (-RRB- -RRB-)) (NP (JJ concomitant) (NN treatment)) (PP (IN with) (NP (NP (NN L-NAME)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 40) (NNS micrograms/kg)) (VP (VBN injected))) (CC plus) (NP (NP (CD 50) (NNS micrograms/kg)) (VP (VBN infused)))) (, ,) (NP (NN i.v.)) (-RRB- -RRB-))))) (, ,) (NP (NP (DT the) (JJ GABAergic) (NN agent) (NN sodium) (NN valproate)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 600) (NN mg)) (PP (IN in) (NP (CD three) (JJ divided) (NNS doses)))) (ADVP (RB orally))) (-RRB- -RRB-))) (CC or) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN L-NAME)) (CC and) (NP (NN sodium) (NN valproate)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN hypoglycemia)) (VP (VBN increased) (PP (IN by) (NP (NP (ADJP (ADJP (JJ 2-fold)) (PRN (-LRB- -LRB-) (NP (NP (NN peak)) (CC vs.) (NP (NN baseline))) (-RRB- -RRB-))) (NN plasma) (NN AVP)) (CC and) (NP (NN _PROT2_) (NNS levels)))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (NP (NP (NP (DT a) (JJ GABAergic) (NN mediation)) (PP (IN of) (NP (NP (DT the) (JJ inhibitory) (NN modulation)) (PP (IN by) (NP (NN NO))) (PP (IN of) (NP (DT the) (NN AVP)))))) (CC and) (NP (NP (JJ _PROT1_) (NNS responses)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-)))) (VP (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN glucagon))) (NN release)) (PP (IN from) (NP (DT the) (NN pancreas))))) (, ,) (CC and) (VP (VB evoke) (NP (NP (NN _PROT_) (NN secretion)) (PP (IN from) (NP (NP (DT the) (NN rat) (NN insulinoma) (NN cell) (NN line)) (, ,) (NP (NN RINm5F))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-)))) (VP (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN glucagon))) (NN release)) (PP (IN from) (NP (DT the) (NN pancreas))))) (, ,) (CC and) (VP (VB evoke) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (DT the) (NN rat) (NN insulinoma) (NN cell) (NN line)) (, ,) (NP (NN RINm5F))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-)))) (VP (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN glucagon))) (NN release)) (PP (IN from) (NP (DT the) (NN pancreas))))) (, ,) (CC and) (VP (VB evoke) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (DT the) (NN rat) (NN insulinoma) (NN cell) (NN line)) (, ,) (NP (NN RINm5F))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Effects)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN arginine-vasopressin)) (CC and) (NP (NN lysine-vasopressin)))) (PP (IN on) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN glucagon))) (NN secretion)) (PP (IN in) (NP (NN sheep)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NP (DT the) (JJ posterior-pituitary) (NNS peptides)) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (, ,) (NP (NP (NN arginine-vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NP (NN lysine-vasopressin)) (PRN (-LRB- -LRB-) (NP (NN LVP)) (-RRB- -RRB-)))))) (PP (IN on) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN glucagon))) (NN secretion)))) (VP (VBD were) (VP (VBN examined) (PP (IN in) (NP (JJ adult) (NN sheep))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT1_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT1_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT2_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT1_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT2_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT1_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Interleukin-1) (NN beta)) (VP (VBZ inhibits) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN secretion))) (PP (IN at) (NP (NP (NNS sites)) (PP (ADVP (RB apart)) (IN from) (NP (NN KATP) (NN channel))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Surprisingly)) (, ,) (ADVP (RB however)) (, ,) (SBAR (WHADVP (WRB when)) (S (NP (NNS islets)) (VP (VBD were) (VP (VBN depolarized) (ADVP (RB directly)) (S (VP (VBG using) (NP (NP (DT either)) (PP (IN of) (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NP (NN glyburide)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB act) (PP (IN via) (NP (NP (NN generation)) (PP (IN of) (NP (NN purine) (NNS nucleotides))))))))) (-RRB- -RRB-)) (CC or) (NP (NP (ADJP (CD 40) (NN mM)) (NN K+)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ acts) (ADJP (JJ distal) (PP (TO to) (NP (NN KATP) (NN channel))))))) (-RRB- -RRB-)))))))))))) (, ,) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NN secretion)) (VP (VBD were) (ADVP (RB again)) (VP (VBN obliterated) (PP (IN by) (NP (NN IL-1) (NN beta)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (PRN (-LRB- -LRB-) (ADVP (RB together)) (PP (IN with) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (NN IL-1) (NN beta)) (VP (VBD inhibited) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN release))))))) (-RRB- -RRB-)) (VP (VBP suggest) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (PRP$ its) (NNS effects)) (PP (PP (IN on) (NP (NN ATP) (NN synthesis))) (CC and) (ADVP (RB thereby)) (PP (IN on) (NP (DT the) (NN KATP) (NN channel)))))))) (, ,) (NP (NN IL-1) (NN beta)) (VP (VBZ has) (NP (QP (IN at) (JJS least) (CD two)) (ADJP (ADJP (JJ undescribed)) (, ,) (ADJP (JJ distal))) (NNS effects)) (PP (TO to) (NP (NP (NN block)) (CC both) (NP (NN _PROT2_)) (CONJP (RB as) (RB well) (IN as)) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN exocytosis)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Association)) (PP (IN of) (NP (DT the) (NN insulin) (NN receptor))) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLCgamma)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ suggests) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (JJ metabolic) (NN signaling)) (PP (IN by) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Association)) (PP (IN of) (NP (DT the) (NN insulin) (NN receptor))) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLCgamma)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ suggests) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT_))) (PP (IN in) (NP (NP (JJ metabolic) (NN signaling)) (PP (IN by) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Association)) (PP (IN of) (NP (DT the) (NN insulin) (NN receptor))) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLCgamma)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ suggests) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (JJ metabolic) (NN signaling)) (PP (IN by) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT2_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT2_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT2_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT2_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT2_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT1_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT2_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (JJ osmotic) (NNS stimuli)) (VP (VBP cause) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NP (JJ nitric) (NN oxide) (NN synthase)) (PRN (-LRB- -LRB-) (NP (NN NOS)) (-RRB- -RRB-))) (NN activity)))) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN synthesis)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT1_)))))) (PP (IN in) (NP (NP (NP (DT the) (NN paraventricular)) (PRN (-LRB- -LRB-) (NP (NN PVN)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ supraoptic) (NNS nuclei)) (PRN (-LRB- -LRB-) (NP (NN SON)) (-RRB- -RRB-)))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN known) (SBAR (IN whether) (S (NP (NP (NN NOS) (NN activity)) (PP (IN in) (NP (DT the) (NN hypothalamus)))) (VP (VBZ changes) (PP (IN in) (NP (NP (DT the) (JJ diabetic) (NNS patients)) (SBAR (WHNP (WP who)) (S (VP (VBP have) (NP (NN plasma) (NN hyperosmolality)) (PP (IN with) (NP (NP (NNS hyperglycaemia)) (VP (VBN caused) (PP (IN by) (NP (NN _PROT2_) (NN deficiency)))))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (NP (CD Three) (NNS weeks)) (IN after) (NP (NP (NN administration)) (PP (IN of) (NP (NN STZ))))) (, ,) (NP (DT the) (JJ diabetic) (NNS rats)) (VP (VBD were) (ADVP (RB subcutaneously)) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN for) (NP (NP (CD 1) (NN week)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD resulted) (PP (IN in) (NP (NP (JJ significant) (NN suppression)) (PP (IN of) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (NP (NN nNOS)) (, ,) (NP (NN AVP)) (CC and) (NP (NN _PROT2_) (NN gene) (NN expression)))) (PP (IN in) (NP (DT the) (NP (NN PVN)) (CC and) (NP (NN SON))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN mRNA)) (PP (IN in) (NP (NP (NP (JJ white) (NN adipose) (NN tissue)) (CC and) (NP (NP (VBG _PROT2_) (NN _PROT2_) (CD _PROT2_)) (NN mRNA))) (PP (IN in) (NP (JJ skeletal) (NN muscle))))))) (PP (IN during) (NP (NP (DT the) (JJ early) (NNS stages)) (PP (IN of) (NP (NN _PROT_) (NN treatment)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN mRNA)) (PP (IN in) (NP (NP (NP (JJ white) (NN adipose) (NN tissue)) (CC and) (NP (NP (VBG _PROT_) (NN _PROT_) (CD _PROT_)) (NN mRNA))) (PP (IN in) (NP (JJ skeletal) (NN muscle))))))) (PP (IN during) (NP (NP (DT the) (JJ early) (NNS stages)) (PP (IN of) (NP (NN _PROT2_) (NN treatment)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN mRNA)) (PP (IN in) (NP (NP (NP (JJ white) (NN adipose) (NN tissue)) (CC and) (NP (NP (VBG _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN mRNA))) (PP (IN in) (NP (JJ skeletal) (NN muscle))))))) (PP (IN during) (NP (NP (DT the) (JJ early) (NNS stages)) (PP (IN of) (NP (NN _PROT2_) (NN treatment)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (PP (IN by) (NP (NP (JJ intravenous) (CC or) (JJ intracerebroventricular) (NN infusion)) (PP (IN for) (NP (CD 5) (NN h)))))) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NP (NP (NN _PROT2_) (NN mRNA)) (PP (IN in) (S (VP (VBD WAT))))) (PRN (-LRB- -LRB-) (NP (CD 47-52) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_) (NN mRNA)) (PP (IN in) (NP (NN SM)))) (PRN (-LRB- -LRB-) (NP (CD 33-37) (NN %)) (-RRB- -RRB-))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (PP (IN by) (NP (NP (JJ intravenous) (CC or) (JJ intracerebroventricular) (NN infusion)) (PP (IN for) (NP (CD 5) (NN h)))))) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NP (NP (NN _PROT_) (NN mRNA)) (PP (IN in) (S (VP (VBD WAT))))) (PRN (-LRB- -LRB-) (NP (CD 47-52) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_) (NN mRNA)) (PP (IN in) (NP (NN SM)))) (PRN (-LRB- -LRB-) (NP (CD 33-37) (NN %)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (PP (IN by) (NP (NP (JJ intravenous) (CC or) (JJ intracerebroventricular) (NN infusion)) (PP (IN for) (NP (CD 5) (NN h)))))) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NP (NP (NN _PROT1_) (NN mRNA)) (PP (IN in) (S (VP (VBD WAT))))) (PRN (-LRB- -LRB-) (NP (CD 47-52) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_) (NN mRNA)) (PP (IN in) (NP (NN SM)))) (PRN (-LRB- -LRB-) (NP (CD 33-37) (NN %)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Denervation)) (VP (VP (VBD suppressed) (NP (NP (NN mRNA) (NNS levels)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 49) (NN %)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 36) (NN %)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN COX-IV)) (PRN (-LRB- -LRB-) (NP (CD 59) (NN %)) (-RRB- -RRB-))))))) (CC and) (VP (VBD eliminated) (NP (NP (DT the) (JJ acute) (NN response)) (PP (TO to) (NP (NN _PROT_))) (PP (IN in) (NP (NN SM)))))))) |ET|
-1 |BT| (S1 (S (NP (NN Denervation)) (VP (VP (VBD suppressed) (NP (NP (NN mRNA) (NNS levels)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 49) (NN %)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 36) (NN %)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN COX-IV)) (PRN (-LRB- -LRB-) (NP (CD 59) (NN %)) (-RRB- -RRB-))))))) (CC and) (VP (VBD eliminated) (NP (NP (DT the) (JJ acute) (NN response)) (PP (TO to) (NP (NN _PROT2_))) (PP (IN in) (NP (NN SM)))))))) |ET|
-1 |BT| (S1 (S (NP (NN Denervation)) (VP (VP (VBD suppressed) (NP (NP (NN mRNA) (NNS levels)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 49) (NN %)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 36) (NN %)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN COX-IV)) (PRN (-LRB- -LRB-) (NP (CD 59) (NN %)) (-RRB- -RRB-))))))) (CC and) (VP (VBD eliminated) (NP (NP (DT the) (JJ acute) (NN response)) (PP (TO to) (NP (NN _PROT2_))) (PP (IN in) (NP (NN SM)))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (PRP$ our) (JJ 14C-acetate-labeling) (NNS studies)) (VP (VBD showed) (NP (NP (DT a) (ADJP (CD 50) (NN %)) (NN reduction)) (PP (IN in) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN synthesis)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (DT either) (NN _PROT2_))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD could) (VP (VB account) (PP (IN for) (NP (NP (DT the) (NN reduction)) (PP (IN in) (NP (NP (JJ net) (NN apoB) (NN secretion)) (VP (VBN caused) (PP (IN by) (NP (NP (NN incubation)) (PP (IN with) (NP (DT these) (NNS compounds)))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (DT the) (JJ fluorinated) (NNS analogues)))) (VP (VBD were) (VP (VBN evaluated) (PP (IN on) (NP (NP (NP (NN inhibition)) (PP (IN of) (NP (NN cress) (JJ seed) (NN germination)))) (CC and) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN induction)) (PP (IN in) (NP (NN embryoless) (NN barley) (NNS half-seeds)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (-LRB- -LRB-) (NN 2E) (, ,) (NN 4E) (-RRB- -RRB-) (CD -2-Fluoro-5-)) (PRN (-LRB- -LRB-) (NP (NP (NN 1'-hydroxy-2) ('' ')) (, ,) (NP (CD 6) ('' ')) (, ,) (NP (NN 6'-trimethyl-2'-cyclohexen-1'-yl))) (-RRB- -RRB-))) (S (S (NP (NP (JJ -3-methyl-2,4-pentadienoic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN 5b)) (-RRB- -RRB-))) (VP (VBD showed) (NP (JJ potent) (JJ inhibitory) (NN activity)) (PP (IN at) (NP (DT the) (JJ same) (NN level))) (PP (IN as) (NP (NP (NN ABA)) (PP (IN in) (NP (DT the) (NN cress) (JJ seed) (NN germination) (NN test))))))) (, ,) (CC and) (S (NP (NN 5b)) (ADVP (RB also)) (VP (VBD inhibited) (NP (JJ _PROT1_) (NN _PROT2_) (NN induction)) (PP (IN at) (NP (NP (QP (QP (QP (QP (CD 4) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (, ,) (CD 3)) (NNS times)) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN ABA)) (PRN (-LRB- -LRB-) (QP (QP (QP (CD 1) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (-RRB- -RRB-)))) (PP (IN for) (NP (NP (ADJP (CD 50) (NN %)) (NN inhibition)) (PP (IN of) (NP (NN _PROT_) (NN production)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (-LRB- -LRB-) (NN 2E) (, ,) (NN 4E) (-RRB- -RRB-) (CD -2-Fluoro-5-)) (PRN (-LRB- -LRB-) (NP (NP (NN 1'-hydroxy-2) ('' ')) (, ,) (NP (CD 6) ('' ')) (, ,) (NP (NN 6'-trimethyl-2'-cyclohexen-1'-yl))) (-RRB- -RRB-))) (S (S (NP (NP (JJ -3-methyl-2,4-pentadienoic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN 5b)) (-RRB- -RRB-))) (VP (VBD showed) (NP (JJ potent) (JJ inhibitory) (NN activity)) (PP (IN at) (NP (DT the) (JJ same) (NN level))) (PP (IN as) (NP (NP (NN ABA)) (PP (IN in) (NP (DT the) (NN cress) (JJ seed) (NN germination) (NN test))))))) (, ,) (CC and) (S (NP (NN 5b)) (ADVP (RB also)) (VP (VBD inhibited) (NP (JJ _PROT1_) (NN _PROT_) (NN induction)) (PP (IN at) (NP (NP (QP (QP (QP (QP (CD 4) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (, ,) (CD 3)) (NNS times)) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN ABA)) (PRN (-LRB- -LRB-) (QP (QP (QP (CD 1) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (-RRB- -RRB-)))) (PP (IN for) (NP (NP (ADJP (CD 50) (NN %)) (NN inhibition)) (PP (IN of) (NP (NN _PROT2_) (NN production)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (-LRB- -LRB-) (NN 2E) (, ,) (NN 4E) (-RRB- -RRB-) (CD -2-Fluoro-5-)) (PRN (-LRB- -LRB-) (NP (NP (NN 1'-hydroxy-2) ('' ')) (, ,) (NP (CD 6) ('' ')) (, ,) (NP (NN 6'-trimethyl-2'-cyclohexen-1'-yl))) (-RRB- -RRB-))) (S (S (NP (NP (JJ -3-methyl-2,4-pentadienoic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN 5b)) (-RRB- -RRB-))) (VP (VBD showed) (NP (JJ potent) (JJ inhibitory) (NN activity)) (PP (IN at) (NP (DT the) (JJ same) (NN level))) (PP (IN as) (NP (NP (NN ABA)) (PP (IN in) (NP (DT the) (NN cress) (JJ seed) (NN germination) (NN test))))))) (, ,) (CC and) (S (NP (NN 5b)) (ADVP (RB also)) (VP (VBD inhibited) (NP (JJ _PROT_) (NN _PROT1_) (NN induction)) (PP (IN at) (NP (NP (QP (QP (QP (QP (CD 4) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (, ,) (CD 3)) (NNS times)) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN ABA)) (PRN (-LRB- -LRB-) (QP (QP (QP (CD 1) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (-RRB- -RRB-)))) (PP (IN for) (NP (NP (ADJP (CD 50) (NN %)) (NN inhibition)) (PP (IN of) (NP (NN _PROT2_) (NN production)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Isolation)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NN gibbestatin) (NN B)) (, ,) (NP (NP (DT an) (NN inhibitor)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,)))) (CC and) (NP (NP (NN gibbestatin) (NN C)) (PP (IN from) (NP (NNS streptomycetaes))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (QP (CD 1) (CC and) (CD 2)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (VP (VBD were) (VP (VBN determined) (PP (IN by) (NP (NP (NP (JJ reverse) (NN transcription-polymerase) (NN chain) (NN reaction)) (PRN (-LRB- -LRB-) (NP (NN RT-PCR)) (-RRB- -RRB-))) (NN methodology))) (PP (IN in) (NP (NP (JJ adipose) (NN tissue)) (CC and) (NP (JJ gastrocnemius) (NN muscle)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT1_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT1_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT2_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT1_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT2_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT1_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT2_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT1_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT2_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT1_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT2_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS aims)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD were)) (: :) (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (S (S (VP (TO to) (VP (VB assess) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (JJ maternal) (NN undernutrition)) (PP (IN during) (NP (NN pregnancy))))) (PP (IN on) (NP (NP (JJ adult) (NN offspring)) (PP (IN with) (NP (NP (NN regard)) (PP (TO to) (NP (NP (NP (NN growth)) (, ,) (NP (NN body) (NN composition)) (CC and) (NP (NN plasma) (NNS levels))) (PP (IN of) (NP (NP (NN glucose)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN corticosterone)))))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NP (NN _PROT2_) (NN treatment)) (ADJP (JJ early) (PP (IN in) (NP (NN life))))) (VP (MD could) (VP (VB ameliorate) (NP (NP (DT the) (JJ adverse) (NNS effects)) (PP (IN of) (NP (NN food) (NN restriction)))) (PP (IN in) (NP (NN utero))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NN activity)) (VP (VBD was) (VP (VBN investigated) (PP (IN by) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN membrane) (NNS preparations)) (VP (VBN obtained) (PP (IN from) (NP (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN beta-TC3)) (-RRB- -RRB-)) (: -)) (, ,) (NP (NP (NN somatostatin)) (PRN (-LRB- -LRB-) (NP (NN Rin) (NN 1027-B2)) (-RRB- -RRB-)) (: -)) (, ,) (CC and) (NP (NN glucagon))) (-LRB- -LRB-) (NN INR1-G9) (-RRB- -RRB-) (JJ -producing) (JJ pancreatic) (NN cell) (NNS lines)))))))) (S (VP (VBG using) (NP (NP (NP (DT the) (JJ non-hydrolyzable) (NN GTP) (NN analogue) (NN GTPgammaS)) (ADVP (RB alone))) (, ,) (NP (NP (DT the) (JJ C-terminal) (NN octapeptide) (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK-8)) (-RRB- -RRB-))) (, ,) (CC or) (NP (NN gastrin))))))))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (PRP it)) (VP (VBD was) (VP (VBN examined) (SBAR (IN whether) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (NN Swiss) (NN 3T3) (NNS cells))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ causes) (NP (NP (NNS changes)) (PP (IN in) (NP (NP (NP (DT the) (JJ subcellular) (NN distribution)) (PP (IN of) (NP (NN EGF) (NNS receptors)))) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (MD could) (ADVP (RB potentially)) (VP (VB explain) (NP (DT the) (VBN observed) (NP (NP (NN synergy)) (CC or) (NP (NN costimulation))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC both) (NP (NN EGF)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADJP (JJ coincident) (PP (IN with) (NP (NP (DT the) (NN EGF) (NN receptor)) (PP (IN in) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (JJ _PROT_) (VBN stimulated) (NNS cells)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC both) (NP (NN EGF)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADJP (JJ coincident) (PP (IN with) (NP (NP (DT the) (NN EGF) (NN receptor)) (PP (IN in) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (JJ _PROT2_) (VBN stimulated) (NNS cells)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC both) (NP (NN EGF)) (CC and) (NP (NN _PROT_))) (VP (VBD stimulated) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADJP (JJ coincident) (PP (IN with) (NP (NP (DT the) (NN EGF) (NN receptor)) (PP (IN in) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (JJ _PROT2_) (VBN stimulated) (NNS cells)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (PRP it)) (VP (VBZ is) (VP (VBN suggested) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NN coclustering)) (PP (IN of) (NP (DT the) (NN EGF) (NN receptor))) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (VP (MD may) (VP (VB allow) (PP (IN for) (NP (NP (JJR greater) (NN efficiency)) (PP (IN of) (NP (NN signal) (NN transduction)))))))))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (DT the) (NN synergy)) (VP (VBN observed) (PP (IN for) (NP (DT these) (CD two) (NNS hormones))) (PP (IN in) (NP (NP (NN stimulation)) (PP (IN of) (NP (NN DNA) (NN synthesis)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN For) (NP (NN example))) (, ,) (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN expression)) (PP (IN in) (NP (DT the) (NN arcuate) (NN nucleus))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Plasma) (NN insulin)) (, ,) (NP (NN cholecystokinin)) (, ,) (NP (NN galanin)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NNS levels))) (PP (IN in) (NP (JJ obese) (NNS women))) (PP (PP (IN with)) (CC and) (PP (IN without) (NP (NN type) (CD 2) (NN diabetes) (NN mellitus))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Experimental) (NNS studies)) (VP (VBD provided) (NP (NP (NNS evidences)) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NP (NN galanin)) (PRN (-LRB- -LRB-) (NP (NN GAL)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC and) (NP (NN insulin))) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (JJ feeding) (NN behaviour))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Plasma) (NNS concentrations)) (PP (IN of) (NP (NP (NN FSH)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN CCK)) (, ,) (NP (NN GAL)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN insulin)))))) (VP (VBD were) (VP (VBN determined) (S (VP (VBG using) (NP (JJ commercial) (NN RIA) (NNS kits)))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (, ,) (PP (FW ie) (NP (NP (JJR higher) (JJ mean) (NN plasma) (NN _PROT1_) (NNS levels)) (PP (IN in) (NP (NP (JJ postmenopausal) (JJ diabetic) (NNS women)) (CC and) (NP (NP (JJ positive) (NN correlation)) (PP (IN of) (NP (NN CCK))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN insulin))))))))) (, ,) (MD may) (VP (VBP suggest) (NP (NP (DT the) (NN role)) (PP (IN of) (NP (DT these) (NNS neuropeptides))) (PP (IN in) (NP (NP (JJ metabolic) (NNS disorders)) (VP (VBG leading) (PP (TO to) (NP (NN type) (CD 2) (NN diabetes) (NN mellitus)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (JJ recent) (NNS evidences)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NNS melanocortins)) (VP (MD could) (VP (VB be) (VP (VBN involved) (PP (PP (IN in) (S (VP (VBG mediating) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (CC and) (PP (IN in) (S (VP (VBG controlling) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Phosphoinositide) (NN hydrolysis)) (, ,) (VP (VBG resulting) (PP (IN in) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN diacylglycerol)) (PRN (-LRB- -LRB-) (NP (NN DG)) (-RRB- -RRB-)))) (NN formation)))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ _PROT2_) (JJ pulsatile) (NN secretion)) (PP (IN of) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-)))) (PP (IN from) (NP (NP (NN uterine) (NN endometrium)) (PP (IN of) (NP (NP (NN sheep)) (CC and) (NP (JJ other) (NNS mammals))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-)))) (PP (IN on) (NP (NP (NP (JJ intracellular) (NN Ca2+) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NN generation)) (PP (IN in) (NP (JJ human) (NN myometrial) (NNS cells))))))) (VP (VBD were) (VP (VP (VBN evaluated)) (CC and) (VP (VBN compared) (PP (TO to) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NNS potencies)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB raise) (NP (NP (NN _PROT2_)) (CC and) (NP (NN [Ca2+) (-RRB- -RSB-) (CD i))))))) (VP (VP (VBD were) (ADJP (ADJP (JJ similar)) (CC and) (ADJP (JJ independent) (PP (IN of) (NP (JJ extracellular) (NN Ca2+)))))) (, ,) (CC and) (VP (MD could) (VP (VB be) (VP (VBN suppressed) (PP (PP (IN by) (NP (NP (NN pertussis) (NN toxin)) (CC and) (NP (NN phorbol) (NN ester)))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NN verapamil)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN action)) (PP (IN of) (NP (NN PGF2) (NN alpha)))) (VP (VBZ depends) (PP (IN on) (NP (JJ extracellular) (NN Ca2+))) (, ,) (SBAR (IN whereas) (S (NP (NN _PROT1_)) (VP (VBZ activates) (NP (NP (DT the) (JJ G-protein-dependent) (NN _PROT2_) (JJ signal-transducing) (NN pathway)) (, ,) (VP (VBN complemented) (PP (IN by) (NP (NP (DT the) (NN influx)) (PP (IN of) (NP (JJ extracellular) (NN Ca2+))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN calcium) (NN response)) (PP (TO to) (NP (NN _PROT1_) (NN application)))) (VP (VBD was) (ADVP (RB principally)) (VP (VBN associated) (PP (IN with) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN calcium) (NNS stores)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Homogeneous) (NN liposome) (NN immunoassay)) (PP (IN for) (NP (NN _PROT1_))) (VP (VBG using) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (NN Clostridium) (NNS perfringens)))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN conjugated) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (NP (NP (DT a) (JJ three-step) (NN procedure)) (PP (IN with) (NP (NP (JJ hetero-bifunctional) (NN crosslinking) (NNS reagents)) (, ,) (ADJP (NN succinimidyl) (CD 4-) (-LRB- -LRB-) (NN N-maleimidomethyl) (-RRB- -RRB-) (JJ cyclohexane-1-carboxylate))))) (CC and) (NP (NP (ADJP (CD 3-) (-LRB- -LRB-) (NN 2-pyridyldithio) (-RRB- -RRB-) (JJ propionic)) (NN acid)) (NN N-hydroxysuccinimide) (NN ester)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CC Both) (NP (NN p-nitrophenylphosphatidylcholine) (JJ hydrolytic) (NN activity)) (CC and) (NP (NN liposome) (JJ lytic) (NN activity))) (PP (IN of) (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_) (NN conjugate)))) (VP (VBD were) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_) (NN antiserum))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CC Both) (NP (NN p-nitrophenylphosphatidylcholine) (JJ hydrolytic) (NN activity)) (CC and) (NP (NN liposome) (JJ lytic) (NN activity))) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT_) (NN conjugate)))) (VP (VBD were) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_) (NN antiserum))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CC Both) (NP (NN p-nitrophenylphosphatidylcholine) (JJ hydrolytic) (NN activity)) (CC and) (NP (NN liposome) (JJ lytic) (NN activity))) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT1_) (NN conjugate)))) (VP (VBD were) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_) (NN antiserum))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN secretion)) (VP (VBZ is) (VP (VBN regulated) (PP (PP (IN by) (NP (NP (NNS changes)) (PP (IN in) (NP (NN blood) (NN glucose))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NP (NP (NP (NNS peptides)) (PP (IN from) (NP (DT the) (JJ gastrointestinal) (NN tract)))) (CC and) (NP (NNS neurotransmitters))) (SBAR (WHNP (WDT that)) (S (VP (VBP activate) (NP (NP (NP (DT the) (JJ pancreatic) (NN islet) (JJ adenylyl) (NN cyclase)) (PRN (-LRB- -LRB-) (NP (FW e.g.) (, ,) (JJ glucagon-like) (NN peptide-1)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (PP (FW e.g.) (, ,) (NP (NN acetylcholine))) (-RRB- -RRB-))) (NP (NN signaling) (NNS pathways))) (S (VP (TO to) (ADVP (RB further)) (VP (VB potentiate) (NP (JJ glucose-induced) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN secretion)) (VP (VBZ is) (VP (VBN regulated) (PP (PP (IN by) (NP (NP (NNS changes)) (PP (IN in) (NP (NN blood) (NN glucose))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NP (NP (NP (NNS peptides)) (PP (IN from) (NP (DT the) (JJ gastrointestinal) (NN tract)))) (CC and) (NP (NNS neurotransmitters))) (SBAR (WHNP (WDT that)) (S (VP (VBP activate) (NP (NP (NP (DT the) (JJ pancreatic) (NN islet) (JJ adenylyl) (NN cyclase)) (PRN (-LRB- -LRB-) (NP (FW e.g.) (, ,) (JJ glucagon-like) (NN peptide-1)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (PP (FW e.g.) (, ,) (NP (NN acetylcholine))) (-RRB- -RRB-))) (NP (NN signaling) (NNS pathways))) (S (VP (TO to) (ADVP (RB further)) (VP (VB potentiate) (NP (JJ glucose-induced) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT_) (NN secretion)) (VP (VBZ is) (VP (VBN regulated) (PP (PP (IN by) (NP (NP (NNS changes)) (PP (IN in) (NP (NN blood) (NN glucose))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NP (NP (NP (NNS peptides)) (PP (IN from) (NP (DT the) (JJ gastrointestinal) (NN tract)))) (CC and) (NP (NNS neurotransmitters))) (SBAR (WHNP (WDT that)) (S (VP (VBP activate) (NP (NP (NP (DT the) (JJ pancreatic) (NN islet) (JJ adenylyl) (NN cyclase)) (PRN (-LRB- -LRB-) (NP (FW e.g.) (, ,) (JJ glucagon-like) (NN peptide-1)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (PP (FW e.g.) (, ,) (NP (NN acetylcholine))) (-RRB- -RRB-))) (NP (NN signaling) (NNS pathways))) (S (VP (TO to) (ADVP (RB further)) (VP (VB potentiate) (NP (JJ glucose-induced) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NN leptin)) (VP (VBD did) (VP (VB constrain) (NP (NP (DT the) (VBN enhanced) (JJ _PROT1_) (NN _PROT2_) (NN secretion)) (ADJP (JJ characteristic) (PP (IN of) (NP (NP (NNS islets)) (PP (IN from) (NP (NN ob/ob) (NNS mice))))))) (, ,) (PP (IN without) (S (VP (VBG influencing) (NP (NP (NN release)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (JJ lean) (NNS mice))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ specific) (NN enhancement)) (PP (IN in) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion)))) (VP (VBZ is) (NP (NP (DT the) (JJS earliest) (VBN reported) (JJ developmental) (NN alteration)) (PP (IN in) (NP (NP (NN _PROT_) (NN secretion)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))))))))) (, ,) (CONJP (CC and) (RB thus)) (NP (NP (DT a) (JJ logical) (NN target)) (PP (IN for) (NP (NN leptin) (NN action)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ specific) (NN enhancement)) (PP (IN in) (NP (JJ _PROT1_) (NN _PROT_) (NN secretion)))) (VP (VBZ is) (NP (NP (DT the) (JJS earliest) (VBN reported) (JJ developmental) (NN alteration)) (PP (IN in) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))))))))) (, ,) (CONJP (CC and) (RB thus)) (NP (NP (DT a) (JJ logical) (NN target)) (PP (IN for) (NP (NN leptin) (NN action)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ specific) (NN enhancement)) (PP (IN in) (NP (JJ _PROT_) (NN _PROT1_) (NN secretion)))) (VP (VBZ is) (NP (NP (DT the) (JJS earliest) (VBN reported) (JJ developmental) (NN alteration)) (PP (IN in) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))))))))) (, ,) (CONJP (CC and) (RB thus)) (NP (NP (DT a) (JJ logical) (NN target)) (PP (IN for) (NP (NN leptin) (NN action)))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN action)) (PP (IN of) (NP (NN leptin))) (PP (IN on) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion)))) (VP (VBD was) (ADJP (ADJP (JJ dose-dependent)) (, ,) (ADJP (JJ rapid-onset))) (PRN (-LRB- -LRB-) (PP (FW i.e.)) (, ,) (PP (IN within) (NP (CD 3) (NN min))) (-RRB- -RRB-)))) (, ,) (CC and) (ADVP (JJ reversible)))) |ET|
-1 |BT| (S1 (S (NP (NN Leptin)) (VP (VBD was) (ADJP (RB equally) (JJ effective) (PP (IN in) (S (VP (VBG constraining) (NP (NP (DT the) (VBN enhanced) (NN _PROT1_) (NN release)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))) (VP (VBN caused) (PP (IN by) (NP (NP (NP (NN protein) (NN kinase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activation))))))))))) (, ,) (NP (NP (DT a) (JJ downstream) (NN mediator)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN signal) (NN pathway))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CD One) (NN function)) (PP (IN of) (NP (NN leptin))) (PP (IN in) (NP (NP (NN control)) (PP (IN of) (NP (NN body) (NN composition)))))) (VP (VBZ is) (S (ADVP (RB thus)) (VP (TO to) (VP (VB target) (NP (NP (DT a) (JJ PKC-regulated) (NN component)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN signaling) (NN system)) (PP (IN within) (NP (NNS islets)))))) (S (VP (TO to) (VP (VB prevent) (NP (NP (NN hypersecretion)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NN brown) (NN fat))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ 2-3-fold) (NN increase)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (JJ dietary) (JJ fat) (NN challenge))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (TO to) (NP (NP (JJ diet-induced) (NNS elevations)) (PP (IN in) (NP (NN plasma) (NN _PROT2_) (NNS levels)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ evokes) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN Ca2+))) (PP (IN from) (NP (JJ _PROT2_) (JJ intracellular) (NNS stores))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN barley) (NN gene)) (VP (VBG encoding) (NP (NP (DT a) (JJ novel) (JJ DNA-binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN HRT)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN identified) (PP (IN by) (NP (NP (NN southwestern) (NN screening)) (PP (IN with) (NP (NP (NNS baits)) (VP (VBG containing) (NP (DT a) (NN _PROT1_) (NN phytohormone) (NN response) (NN element)) (PP (IN from) (NP (DT an) (NN _PROT2_) (NN promoter)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Oxytocin-stimulated) (NN _PROT1_) (NN release)) (PP (IN in) (NP (DT a) (JJ clonal) (NN beta-cell) (NN line) (CD RINm5F)))) (: :) (NP (NP (NN involvement)) (PP (IN of) (NP (ADJP (ADJP (NN _PROT2_) (JJ _PROT2_)) (CC and) (ADJP (JJ -independent))) (NNS pathways)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NN Oxy)) (VP (VBZ increases) (NP (NN _PROT1_) (NN release)) (PP (IN through) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN non-PLC)) (NP (VBN mediated) (NN signal) (NN transduction) (NNS mechanisms)))))) (. .)))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN U-73122)) (VP (VBD diminished) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NP (JJ intracellular) (NN concentration)) (PP (IN of) (NP (NN _PROT2_) (CD _PROT2_)))))) (, _PROT2_) (S (NP (NP (CD _PROT2_)) (, _PROT2_) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-)))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT2_))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN insulin) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT_))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN insulin) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT1_))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN insulin) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN release)) (PP (IN in) (NP (DT a) (JJ clonal) (NN beta-cell) (NN line) (CD RINm5F)))) (: :) (NP (NP (NN involvement)) (PP (IN of) (NP (ADJP (ADJP (NN phospholipase) (JJ C-dependent)) (CC and) (ADJP (JJ -independent))) (NNS pathways))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN AIM)) (: :) (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS mechanisms)) (VP (VBG underlying) (NP (ADJP (NN _PROT1_) (-LRB- -LRB-) (NN Oxy) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN release)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NN _PROT1_)) (VP (VBD increased) (NP (NP (NN _PROT2_) (NN release)) (CC and) (NP (NN [Ca2+) (-RRB- -RSB-) (CD i))) (PP (IN in) (NP (DT a) (JJ concentration-dependent) (NN manner)))))))) |ET|
+1 |BT| (S1 (S (NP (JJ _PROT1_) (NN _PROT2_) (NN release)) (VP (VBD was) (RB not) (VP (VBN altered) (PP (IN by) (NP (NP (NN pretreatment)) (PP (IN with) (NP (NP (NN pertussis) (NN toxin)) (PRN (-LRB- -LRB-) (NP (NN PT)) (-RRB- -RRB-)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN IP3))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN _PROT_) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN IP3))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN IP3))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NN _PROT2_) (NN release)) (PP (IN through) (NP (CC both) (NP (NN PLC)) (CC and) (NP (ADJP (NN non-PLC) (JJ mediated)) (NN signal) (NN transduction) (NNS mechanisms))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (VBN isolated) (NNS adipocytes))) (, ,) (NP (NP (DT the) (NN loss)) (PP (IN of) (NP (RB almost) (NN half)))) (S (NP (NP (DT the) (NN 18S) (NN RNA) (NN content)) (PP (IN over) (NP (DT a) (JJ 24-hour) (NN incubation)))) (VP (VBD was) (VP (VBN prevented) (PP (IN in) (DT the) (NN presence) (IN of) (NP (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))) (CC or) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN EGF)) (-RRB- -RRB-)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Further) (NN investigation)) (VP (VBD suggested) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (JJ intracellular) (NN signalling) (NN pathway))))))) (, ,)))) (VP (VBZ is) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (DT the) (JJ synergistic) (NN response)))))) (, ,) (SBAR (IN although) (S (NP (PRP it)) (VP (VBZ is) (RB not) (ADJP (JJ obligatory) (PP (IN for) (NP (JJ _PROT_) (NN ACTH) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Further) (NN investigation)) (VP (VBD suggested) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT_) (JJ intracellular) (NN signalling) (NN pathway))))))) (, ,)))) (VP (VBZ is) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (DT the) (JJ synergistic) (NN response)))))) (, ,) (SBAR (IN although) (S (NP (PRP it)) (VP (VBZ is) (RB not) (ADJP (JJ obligatory) (PP (IN for) (NP (JJ _PROT2_) (NN ACTH) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Further) (NN investigation)) (VP (VBD suggested) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (JJ intracellular) (NN signalling) (NN pathway))))))) (, ,)))) (VP (VBZ is) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (DT the) (JJ synergistic) (NN response)))))) (, ,) (SBAR (IN although) (S (NP (PRP it)) (VP (VBZ is) (RB not) (ADJP (JJ obligatory) (PP (IN for) (NP (JJ _PROT2_) (NN ACTH) (NN release))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ bovine) (JJ ovarian) (NN granulosa) (NN cell) (NN model)) (VP (VBZ is) (NP (NP (DT a) (JJ primary) (NN culture) (NN system)) (SBAR (WHADVP (WRB where)) (S (PP (IN under) (NP (NP (NN stimulation)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NP (NN IGF-I)) (CC and) (NP (NN LH))))))) (NP (DT the) (JJ endogenous) (NN _PROT2_) (NN gene)) (VP (VBZ is) (ADVP (RB massively)) (VP (VBN upregulated))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (ADJP (JJ abscisic) (JJ acid-mediated)) (NN inhibition)) (PP (IN of) (NP (JJ _PROT1_) (NNS responses)))) (VP (VBZ seems) (S (VP (TO to) (VP (VB depend) (PP (IN on) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT a) (NN phospholipase) (NN D))) (PP (PP (IN during) (NP (NP (NN induction)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NN barley) (NN aleurone) (NNS cells))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN on) (NP (NP (DT a) (JJ putative) (NN acetyltransferase)) (VP (VBN involved) (PP (IN in) (NP (NN elongation) (NN growth))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Effects)) (PP (IN of) (NP (ADJP (RB intravenously) (VBN infused)) (NN _PROT1_))) (PP (PP (IN on) (NP (NN insulin) (NN sensitivity))) (CC and) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NNS _PROT2_))) (PP (IN in) (NP (JJ brown) (NN adipose) (NN tissue))))))))) |ET|
+1 |BT| (S1 (S (NP (ADJP (RB Centrally) (VBN administered)) (NN _PROT1_)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (VP (TO to) (VP (VB increase) (NP (JJ insulin-stimulated) (NN glucose) (NN utilization)))) (CC and) (VP (TO to) (VP (VB favor) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS UCPs)) (-RRB- -RRB-)))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB study) (SBAR (IN if) (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ has) (NP (JJ direct) (ADJP (RB peripherally) (VBN mediated)) (NNS effects)) (PP (IN on) (NP (DT these) (NNS processes))))))))) (, ,) (S (NP (NP (NP (DT this) (NN hormone)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN mg/day)) (-RRB- -RRB-))) (CC or) (NP (PRP$ its) (NN vehicle))) (VP (VBD was) (VP (VBN infused) (PRT (RP i.v.)) (PP (IN for) (NP (NP (CD 4) (NNS days)) (PP (TO to) (NP (JJ lean) (NNS rats)))))))) (CC and) (S (NP (NP (NP (JJ insulin-stimulated) (NN glucose) (NN utilization)) (PP (IN in) (NP (NP (JJ skeletal) (NN muscle)) (CC and) (NP (JJ adipose) (NN tissue))))) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NN messenger) (NNS RNAs)) (PRN (-LRB- -LRB-) (NP (NNS mRNAs)) (-RRB- -RRB-)))) (PP (IN in) (NP (JJ brown) (NN adipose) (NN tissue))))) (VP (VBD were) (VP (VBN measured)))))) |ET|
+1 |BT| (S1 (S (S (NP (NN I.v.) (NN _PROT1_) (NN infusion)) (ADVP (RB also)) (VP (VBN favored) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NNS _PROT2_))) (PP (PP (IN in) (NP (JJ brown) (NN adipose) (NN tissue))) (, ,) (CC either) (PP (IN by) (S (VP (VP (VBG increasing) (NP (PRP$ their) (NN expression))) (CC or) (VP (VBG preventing) (S (NP (DT the)) (VP (VBP fall) (VP (VBG occurring) (PP (IN during) (NP (DT the) (JJ pair-feeding) (NN regimen)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT2_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT1_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ overall) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (PP (IN on) (NP (NN glucose) (NN utilization))) (CC and) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NNS _PROT2_))))))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN through) (NP (JJ central) (NN mechanism))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN catalase)))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB significantly)) (VP (VBN enhanced) (PP (IN in) (NP (NP (DT the) (NNS tissues)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (NN _PROT1_) (JJ fed))) (NNS rats)) (VP (VBN administered) (NP (NP (ADJP (CD 1) (NN mg)) (NN _PROT2_)) (PP (IN from) (NP (NN brinjal/100) (NN g) (NN BW/day))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (PRP We)) (VP (VBP have) (ADVP (RB therefore)) (VP (VBN studied) (NP (NP (NP (NP (JJ possible) (NNS associations)) (PP (IN of) (NP (DT the) (NN Gln27Glu)))) (CC and) (NP (NP (DT the) (NN Gly16Arg) (NNS polymorphisms)) (PP (IN in) (NP (NP (DT the) (NN beta2AR)) (PP (IN with) (NP (NN BMI))))))) (, ,) (NP (NP (NN plasma) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN mRNA) (NN expression)))) (PP (IN in) (NP (NP (DT the) (JJ intraperitoneal) (NN adipose) (NN tissue)) (PP (IN in) (NP (NP (DT a) (NN population)) (PP (IN of) (NP (NN Caucasian) (NNS women))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (DT no) (NN association)) (VP (VBD was) (VP (VBN found) (PP (IN between) (NP (NP (DT the) (NP (NP (NN Gln27Glu)) (CC or) (NP (DT the) (NN Gly16Arg))) (NNS polymorphisms)) (CC and) (NP (NP (NN plasma) (NN _PROT1_)) (CC or) (NP (NN adipose) (NN tissue)) (NP (NN _PROT2_) (NN gene) (NN expression))))) (PP (IN in) (NP (DT either) (NN group))))))) |ET|
-1 |BT| (S1 (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS effects)) (PP (IN of) (NP (NN CGP-12177))) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS genes)))) (PP (IN in) (NP (NN mouse) (ADJP (ADJP (JJ brown)) (CC and) (ADJP (JJ white))) (NN adipose) (NNS tissues)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN effect)) (PP (PP (IN of) (NP (NP (JJ chronic) (NN treatment)) (PP (IN with) (NP (NP (CD CGP-12177)) (NP (DT a) (JJ beta3-adrenergic) (NN receptor) (-LRB- -LRB-) (NN AR) (-RRB- -RRB-) (NN agonist)))) (PP (IN with) (NP (JJ beta2/beta1-AR) (NN antagonist) (NN action))))) (, ,) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene))))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN ucp1)) (, ,) (NP (NN ucp2)) (CC and) (NP (NN ucp3))) (-RRB- -RRB-)))))))) (PP (IN in) (NP (ADJP (ADJP (JJ brown)) (CC and) (ADJP (JJ white))) (NN adipose) (NNS tissues)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT1_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT2_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT1_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT1_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT1_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT1_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC neither) (NP (NN progesterone)) (CC nor) (NP (NN _PROT1_))) (VP (VBD increased) (NP (NP (NN phosphotyrosine)) (PP (IN on) (NP (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_AND_PROT2_)) (: :) (NP (NP (JJ opposing) (NNS effects)) (PP (IN on) (NP (NP (ADJP (ADJP (JJ appetitive)) (CC and) (ADJP (JJ consummatory))) (NN ingestive) (NN behavior)) (CC and) (NP (JJ sexual) (NN behavior)))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Many) (NNS studies)) (VP (VBP have) (VP (VBN indicated) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (VP (VBZ stimulates))) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ inhibits) (NP (NN food) (NN intake)))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN line)) (PP (IN with) (NP (DT this))))) (, ,) (NP (NP (JJ intracerebroventricular) (NN injection)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 10) (NN microg)) (-RRB- -RRB-))))) (VP (VBD stimulated))) (S (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 10) (NN microg)) (-RRB- -RRB-))) (VP (VBD inhibited) (NP (NP (NN intake)) (PP (IN of) (NP (DT a) (NN sucrose) (NN solution)))) (SBAR (WHADVP (WRB when)) (S (NP (JJ female) (NNS rats)) (VP (VBD were) (VP (VBN required) (S (VP (TO to) (VP (VB obtain) (NP (DT the) (NN solution)) (PP (IN from) (NP (DT a) (JJ bottle)))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBD inhibited))) (CC and) (S (NP (NN _PROT2_)) (VP (VBD stimulated) (NP (NN intake)) (SBAR (IN if) (S (NP (DT the) (NN solution)) (VP (VBD was) (VP (VBN infused) (ADVP (RB intraorally))))))))))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT1_)) (VP (VP (VBZ stimulates) (NP (NP (DT the) (NNS responses)) (VP (VBN used) (S (VP (TO to) (VP (VB obtain) (NP (NN food)))))))) (CC but) (VP (VBZ inhibits) (NP (NP (DT those)) (VP (VBN used) (S (VP (TO to) (VP (VB consume) (NP (NN food)))))))))) (, ,) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (DT the) (JJ opposite) (NNS effects)))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD determined) (SBAR (IN whether) (S (NP (NP (ADJP (RB well) (JJ known)) (JJ hypothalamic) (NN neuropeptide) (NNS targets)) (, ,) (PP (FW e.g.) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NP (NN proopiomelanocortin)) (PRN (-LRB- -LRB-) (NP (JJ POMC)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ agouti-related) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN AGRP)) (-RRB- -RRB-))) (CC and) (NP (NP (NN cocaine)) (CC and) (NP (NP (JJ amphetamine-regulated) (NN transcript)) (PRN (-LRB- -LRB-) (NP (NN CART)) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN regulated) (PP (IN in) (NP (NP (DT a) (NN pattern)) (ADJP (JJ consistent) (PP (IN with) (NP (PRP$ their) (JJ presumed) (NNS roles)))))) (PP (IN as) (NP (NP (NNS mediators)) (PP (IN of) (NP (NN _PROT2_) (NN action)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBD decreased) (NP (NP (NN body) (NN weight)) (CC and) (NP (NN adiposity)))) (, ,) (VP (VBD increased) (NP (NN CART))) (CC and) (VP (VBD suppressed) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN AGRP))) (NN mRNA) (NN expression)) (PP (IN in) (NP (JJ adult) (NNS mice)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT1_) (NN beta) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 25-35)) (-RRB- -RRB-))) (NN stimulation)) (PP (IN of) (NP (NP (NP (NP (NN _PROT2_) (NN A)) (, ,) (NP (NN C)) (CC and) (NP (NN D))) (NNS activities)) (PP (IN of) (NP (NN LA-N-2) (NNS cells)))))))) |ET|
-1 |BT| (S1 (S (LST (LS [3H) (-RRB- -RSB-)) (S (S (NP (NN Inositol) (JJ prelabeled) (NN LA-N-2) (NNS cells)) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NP (JJ varying) (NNS concentrations)) (PP (IN of) (NP (DT _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (, ,) (PP (IN from) (NP (QP (CD 20) (TO to) (CD 125)) (NNS micrograms/ml)))))) (, ,) (CC and) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)) (VP (VBD was) (VP (VBN measured))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (JJ adrenergic) (, ,) (NP (NP (JJ metabotropic) (NN amino) (NN acid)) (CC and) (NP (NN bombesin))) (NNS antagonists))) (PP (IN on) (NP (NP (DT the) (ADJP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ mediated)) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN activity)))))) (VP (VBD was) (VP (VBN investigated))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Propranolol)) (, ,) (NP (NP (DT a) (NN beta) (JJ adrenergic) (NN antagonist)) (, ,) (NP (JJ 7-chloro-kynurenic) (NN acid))) (, ,) (NP (DT a) (JJ metabotropic) (NN amino) (NN acid) (NN antagonist)) (, ,) (CC and) (NP (NN [Tyr4-D-Phe12)) (-RRB- -RSB-) (NP (NN bombesin)) (, ,) (NP (DT a) (NN bombesin) (NN antagonist)) (, ,)) (VP (VBD blunted) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN stimulation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activity))) (PP (IN in) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol)))))) (NP (JJ prelabeled) (NN LA-N-2) (NNS cells)))) |ET|
+1 |BT| (S1 (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN beta) (NN protein) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (MD may) (VP (VB be) (NP (NP (NN receptor)) (VP (VBN mediated)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN inhibitor)) (NP (NN U) (NN 71322))) (VP (VBD prevented) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (DT _PROT_) (NN _PROT_) (NN _PROT_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN inhibitor)) (NP (NN U) (NN 71322))) (VP (VBD prevented) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT_) (NN _PROT_) (NN inhibitor)) (NP (NN U) (NN 71322))) (VP (VBD prevented) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN by) (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN secretion)) (CC and) (NP (NP (DT _PROT2_) (NN _PROT2_) (NN production)) (PP (IN in) (NP (NN NT2N) (NNS neurons))))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN signal) (NN transduction) (NN pathway)))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN secretion)) (CC and) (NP (NP (DT _PROT_) (NN _PROT_) (NN production)) (PP (IN in) (NP (NN NT2N) (NNS neurons))))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN signal) (NN transduction) (NN pathway)))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN secretion)) (CC and) (NP (NP (DT _PROT1_) (NN _PROT1_) (NN production)) (PP (IN in) (NP (NN NT2N) (NNS neurons))))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN signal) (NN transduction) (NN pathway)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Current) (NN interest)) (PP (IN in) (NP (NN reducing) (NN heart) (NN disease) (NNS risks))) (PP (IN by) (NP (NN diet)))) (VP (VBZ involves) (NP (NP (NN attention)) (PP (TO to) (NP (JJ total) (NN fat)))))) (: ;) (S (NP (NP (ADJP (ADJP (JJ saturated)) (, ,) (ADJP (JJ monounsaturated)) (, ,) (ADJP (JJ polyunsaturated)) (CC and) (ADJP (JJ trans))) (JJ fatty) (NNS acids)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ dietary) (NN _PROT1_)) (, ,) (NP (JJ soluble) (NN fiber)) (, ,) (NP (NN salt)) (, ,) (NP (NN alcohol))) (, ,) (NP (NNS antioxidants)) (, ,) (NP (JJ dietary) (NNS alterations))) (VP (VBG causing) (NP (NP (NP (NN homocysteinemia)) (CC and) (NP (JJ other) (JJ dietary) (NNS constituents))) (, ,) (NP (ADJP (JJ such) (PP (IN as) (NP (NP (NN _PROT2_) (NNS compounds)) (PP (IN in) (NP (DT some) (NN soy)))))) (NNS products))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ cAMP-dependent) (NN phosphorylation)) (PP (IN at) (NP (NP (DT a) (NN step)) (VP (VBG involving) (NP (JJ GTP-binding) (NN protein/PLC) (NN coupling)))))) (VP (MD can) (VP (VP (VB exert) (NP (DT a) (JJ negative) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN _PROT1_) (NN formation))) (PP (IN by) (NP (NN _PROT2_)))))) (CC and) (RB thereby) (VP (VB affect) (NP (NP (NN contraction/relaxation)) (PP (IN in) (NP (DT the) (NN myometrium)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Roles)) (PP (IN of) (NP (NP (NN GTP)) (CC and) (NP (NN _PROT1_) (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))) (PP (IN by) (NP (NN glucose))) (PP (IN in) (NP (NN rat) (JJ pancreatic) (NNS islets)))))))) |ET|
-1 |BT| (S1 (S (S (NP (EX There)) (VP (VBD was) (NP (NP (DT a) (ADJP (NP (CD 98) (NN %)) (JJR greater)) (NN augmentation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))) (PP (IN by) (NP (ADJP (CD 16.7) (NN mM)) (NN glucose)))) (-LRB- -LRB-) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NN diazoxide)) (CC and) (NP (ADJP (CD 40) (NN mM)) (NN K+)))))) (-RRB- -RRB-) (PP (IN in) (NP (JJ primed) (NNS islets))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (JJ high) (NN glucose))) (S (VP (TO to) (VP (VB augment) (NP (NN _PROT2_) (NN activity)))))) (VP (VBD bore) (NP (DT no) (NN relationship)) (PP (TO to) (NP (DT the) (JJ secretory) (NN response))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN MPA)) (ADVP (RB markedly)) (VP (VBD inhibited) (NP (NN _PROT1_)) (PP (IN in) (NP (DT both) (NNS conditions))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NN _PROT2_) (NN secretion)) (VP (VBD was) (ADVP (RB only)) (VP (VBN inhibited) (PRN (-LRB- -LRB-) (PP (IN by) (NP (CD 46) (NN %))) (-RRB- -RRB-)) (PP (IN in) (NP (JJ primed) (NNS islets)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT2_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT2_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT2_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT1_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Regulation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))) (PP (IN via) (NP (NP (JJ ATP-sensitive) (NN K+) (NN channel)) (JJ independent) (NNS mechanisms)))) (: :) (NP (NP (NN role)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ further) (NN addition)) (PP (IN of) (NP (NP (NP (NN carbachol)) (, ,) (NP (NP (DT an) (NN agonist)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (NP (DT an) (NN isozyme)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN activated) (PP (IN by) (NP (NN glucose)))))))) (, ,) (PP (ADVP (RB together)) (IN with) (NP (NN K+)))))))) (, ,) (NP (ADJP (CD 20) (NN mM)) (NN glucose)) (, ,) (CC plus) (NP (NN diazoxide))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ sustained) (NN amplification)) (PP (IN of) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (NP (NN mouse)) (CONJP (CC but) (RB not)) (NP (NN rat))) (NNS islets)))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN inability) (S (VP (TO to) (VP (VB activate) (NP (NP (DT a) (ADJP (ADJP (JJ nutrient-)) (CC and) (ADJP (JJ calcium-regulated))) (NN _PROT1_) (NN _PROT1_) (NN isozyme)) (PP (IN in) (NP (NN mouse) (NNS islets))) (PP (TO to) (NP (NP (DT the) (JJ same) (NN extent)) (PP (IN as) (PP (IN in) (NP (NN rat) (NNS islets))))))))))) (VP (VBZ appears) (S (VP (TO to) (VP (VB account) (, ,) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (, ,) (PP (IN for) (NP (DT these) (JJ different) (NN _PROT2_) (JJ secretory) (NNS responses))) (PP (IN under) (NP (DT these) (JJ unique) (NNS conditions))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Further)) (, ,) (NP (NP (DT the) (JJ _PROT1_) (NN activation)) (PP (IN of) (NP (NP (NN IK)) (PRN (-LRB- -LRB-) (NP (NN sl)) (-RRB- -RRB-))))) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN antagonized) (PP (PP (IN by) (NP (NP (QP (QP (CD 5) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -8)) (-RRB- -RRB-))) (NN mol/l) (NN U-73122)) (CC or) (NP (NP (QP (QP (CD 5) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -6)) (-RRB- -RRB-))) (NN mol/l) (NN 2-nitro-4-carboxyphenyl) (NN N)) (, ,) (NP (NP (NN N-diphenylcarbamate)) (PRN (-LRB- -LRB-) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (DT the) (NN cell) (NN membrane) (NN phospholipase) (NN C)))) (-RRB- -RRB-)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (ADJP (RB intracellularly) (VBN applied)) (NN heparin)))))) (PRN (-LRB- -LRB-) (NP (NP (JJ selective) (NN inhibitor)) (PP (IN of) (NP (ADJP (NN _PROT2_) (-LRB- -LRB-) (NN IP3) (-RRB- -RRB-) (JJ -induced)) (NN Ca2+) (NN release) (NNS channels)))) (-RRB- -RRB-)))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS data)) (VP (VBN obtained))) (VP (VBP suggest) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (PP (IN that) (S (NP (JJ selective) (NN _PROT1_) (NNS receptors)) (VP (VBP are) (ADJP (JJ present) (PP (IN on) (NP (NP (DT the) (NNS membranes)) (PP (IN of) (NP (JJ guinea-pig) (JJ antral) (NN smooth) (NN muscle) (NNS cells))))))))) (, ,) (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (PP (IN that) (S (S (NP (DT the) (JJ oxytocin-related) (NN relaxation)) (VP (MD may) (VP (VB result) (PP (IN from) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -sensitive)) (NN K+) (NN conductivity))))) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NP (JJ _PROT2_) (NN release)) (PP (IN of) (NP (NN Ca2+))) (PP (IN from) (NP (NP (DT the) (JJ submembrane) (JJ located) (NNS cisternae)) (PP (IN of) (NP (NP (DT the) (JJ sarcoplasmic) (NN reticulum)) (NN Ca2+) (NNS stores)))))))))))) (CC and) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (PP (IN in) (NP (NN turn))) (, ,) (NP (DT this)) (VP (VBZ evokes) (NP (NP (DT a) (JJ non-inactivating) (NN component)) (PP (IN of) (NP (NN IK)))) (, ,) (S (VP (VBG hyperpolarizing) (NP (DT the) (NN cell) (NN membrane)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ potent) (NNS antioxidants)) (, ,) (PP (JJ such) (IN as) (NP (NNS _PROT1_))) (, ,)) (VP (VP (VB protect) (NP (NP (NN MM-LDL)) (PP (IN from) (NP (NN lipoperoxidation))))) (CC and) (VP (VB preserve) (NP (PRP$ their) (NN ability) (S (VP (TO to) (ADVP (RB efficiently)) (VP (VB deliver) (NP (NN _PROT2_)) (PP (TO to) (NP (NNS cells)))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT2_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT2_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT1_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT1_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NNS TZDs))) (PP (IN in) (NP (DT the) (VBD WAT) (NP (CC and) (NP (NN BAT)) (PP (IN in) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT an) (JJ obese) (NN model)) (PP (IN with) (NP (NN _PROT2_) (NN receptor) (NN defect))))))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN adipose) (NN _PROT_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN increased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NNS TZDs))))) (ADVP (FW in) (FW vitro)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NNS TZDs))) (PP (IN in) (NP (DT the) (VBD WAT) (NP (CC and) (NP (NN BAT)) (PP (IN in) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT an) (JJ obese) (NN model)) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect))))))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN adipose) (NN _PROT2_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN increased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NNS TZDs))))) (ADVP (FW in) (FW vitro)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NNS TZDs))) (PP (IN in) (NP (DT the) (VBD WAT) (NP (CC and) (NP (NN BAT)) (PP (IN in) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT an) (JJ obese) (NN model)) (PP (IN with) (NP (NN _PROT1_) (NN receptor) (NN defect))))))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN adipose) (NN _PROT2_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN increased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NNS TZDs))))) (ADVP (FW in) (FW vitro)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (VBN Enhanced) (JJ phosphoinositide) (NN hydrolysis)) (PP (IN via) (NP (NP (NN overexpression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN beta1) (NN or) (NN delta1)))))) (VP (VBZ inhibits) (NP (NP (JJ stimulus-induced) (NN _PROT2_) (NN release)) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (VBN enhanced) (JJ phosphoinositide) (NN hydrolysis))) (PP (IN on) (NP (NN _PROT1_) (NN secretion))))))) (, ,) (NP (NP (NP (JJ phosphoinositide-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLCbeta1)) (-RRB- -RRB-))) (CC or) (NP (NN _PROT_))) (VP (VBD was) (VP (VBN overexpressed) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells))) (PP (IN via) (NP (JJ adenoviral) (NNS vectors)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (VBN enhanced) (JJ phosphoinositide) (NN hydrolysis))) (PP (IN on) (NP (NN _PROT1_) (NN secretion))))))) (, ,) (NP (NP (NP (JJ phosphoinositide-specific) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLCbeta1)) (-RRB- -RRB-))) (CC or) (NP (NN _PROT2_))) (VP (VBD was) (VP (VBN overexpressed) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells))) (PP (IN via) (NP (JJ adenoviral) (NNS vectors)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (VBN enhanced) (JJ phosphoinositide) (NN hydrolysis))) (PP (IN on) (NP (NN _PROT_) (NN secretion))))))) (, ,) (NP (NP (NP (JJ phosphoinositide-specific) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLCbeta1)) (-RRB- -RRB-))) (CC or) (NP (NN _PROT2_))) (VP (VBD was) (VP (VBN overexpressed) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells))) (PP (IN via) (NP (JJ adenoviral) (NNS vectors)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Constitutive) (NN expression)) (PP (IN of) (NP (NN PKABA1)))) (ADVP (RB drastically)) (VP (VBD suppressed) (NP (NP (NN expression)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ low-)) (CC and) (ADJP (JJ high-pI))) (NP (NP (NN _PROT1_)) (CC and) (NP (NN protease))) (NNS genes)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Long-term) (NNS changes)) (PP (IN in) (NP (NP (NN gastrin)) (, ,) (NP (NN cholecystokinin)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NN response) (TO to) (NP (NN _PROT2_) (NN treatment)))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBD was) (VP (VBN designed) (S (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (JJ repeated) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBP influence) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (ADJP (RB vagally) (VBN controlled)) (NNS hormones)) (PP (JJ such) (IN as) (NP (NP (NN gastrin)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN somatostatin)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN of) (NP (NP (JJ endogenous) (NN _PROT_)) (CC and) (NP (NN glucose))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBD was) (VP (VBN designed) (S (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (JJ repeated) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBP influence) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (ADJP (RB vagally) (VBN controlled)) (NNS hormones)) (PP (JJ such) (IN as) (NP (NP (NN gastrin)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN somatostatin)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN of) (NP (NP (JJ endogenous) (NN _PROT2_)) (CC and) (NP (NN glucose))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBD was) (VP (VBN designed) (S (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (JJ repeated) (NNS injections)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBP influence) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (ADJP (RB vagally) (VBN controlled)) (NNS hormones)) (PP (JJ such) (IN as) (NP (NP (NN gastrin)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN somatostatin)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN of) (NP (NP (JJ endogenous) (NN _PROT2_)) (CC and) (NP (NN glucose))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN CCK))) (NNS levels)) (VP (VBD were) (VP (VBN decreased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN treatment))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN measured) (PP (NP (QP (CD 3) (CC and) (CD 10)) (NNS days)) (IN after) (NP (NP (DT the) (JJ last) (NN injection)) (PRN (-LRB- -LRB-) (NP (NN ANOVA)) (: ;) (NP (NN _PROT_) (NN p) (NN <) (CD 0.01)) (, ,) (NP (NN CCK) (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN CCK))) (NNS levels)) (VP (VBD were) (VP (VBN decreased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (DT the) (NN _PROT_) (NN treatment))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN measured) (PP (NP (QP (CD 3) (CC and) (CD 10)) (NNS days)) (IN after) (NP (NP (DT the) (JJ last) (NN injection)) (PRN (-LRB- -LRB-) (NP (NN ANOVA)) (: ;) (NP (NN _PROT2_) (NN p) (NN <) (CD 0.01)) (, ,) (NP (NN CCK) (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN CCK))) (NNS levels)) (VP (VBD were) (VP (VBN decreased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN treatment))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN measured) (PP (NP (QP (CD 3) (CC and) (CD 10)) (NNS days)) (IN after) (NP (NP (DT the) (JJ last) (NN injection)) (PRN (-LRB- -LRB-) (NP (NN ANOVA)) (: ;) (NP (NN _PROT2_) (NN p) (NN <) (CD 0.01)) (, ,) (NP (NN CCK) (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NP (DT the) (JJ alpha2-adrenoreceptor) (NN agonist) (NN clonidine)) (PRN (-LRB- -LRB-) (NP (CD 2.5) (NN microgram/kg) (NN intracerebroventricularly)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN administered) (PP (NP (CD 3) (NNS days)) (IN after) (NP (DT the) (JJ 5-day) (NN treatment) (NN period))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (NN saline)))))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN CCK))))) (VP (VBD increased) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN in) (NP (DT the) (JJ _PROT_) (NNS rats)))) (, ,) (SBAR (WHADVP (WRB when)) (S (VP (VBN compared) (PP (TO to) (NP (NP (JJ saline-treated) (NNS controls)) (VP (VBG receiving) (NP (NP (NN clonidine)) (ADVP (RB only))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NP (DT the) (JJ alpha2-adrenoreceptor) (NN agonist) (NN clonidine)) (PRN (-LRB- -LRB-) (NP (CD 2.5) (NN microgram/kg) (NN intracerebroventricularly)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN administered) (PP (NP (CD 3) (NNS days)) (IN after) (NP (DT the) (JJ 5-day) (NN treatment) (NN period))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (NN saline)))))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN CCK))))) (VP (VBD increased) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NNS rats)))) (, ,) (SBAR (WHADVP (WRB when)) (S (VP (VBN compared) (PP (TO to) (NP (NP (JJ saline-treated) (NNS controls)) (VP (VBG receiving) (NP (NP (NN clonidine)) (ADVP (RB only))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NP (DT the) (JJ alpha2-adrenoreceptor) (NN agonist) (NN clonidine)) (PRN (-LRB- -LRB-) (NP (CD 2.5) (NN microgram/kg) (NN intracerebroventricularly)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN administered) (PP (NP (CD 3) (NNS days)) (IN after) (NP (DT the) (JJ 5-day) (NN treatment) (NN period))) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (NN saline)))))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN CCK))))) (VP (VBD increased) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NNS rats)))) (, ,) (SBAR (WHADVP (WRB when)) (S (VP (VBN compared) (PP (TO to) (NP (NP (JJ saline-treated) (NNS controls)) (VP (VBG receiving) (NP (NP (NN clonidine)) (ADVP (RB only))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN conclusion))) (, ,) (NP (DT these) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (NP (JJ long-lasting) (NNS changes)) (PP (IN in) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN gastrin)) (, ,) (NP (NN CCK)) (CC and) (NP (NN _PROT2_))))))) (, ,) (PP (IN without) (S (VP (VBG affecting) (NP (NP (NP (NN somatostatin)) (CC or) (NP (NN glucose))) (NNS levels))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Plasma) (NN _PROT1_)) (, ,) (CC and) (NP (NP (DT some) (ADJP (RB functionally) (JJ related)) (NNS peptides)) (PRN (-LRB- -LRB-) (NP (NP (NN CCK)) (, ,) (NP (NN gastrin)) (, ,) (NP (NN somatostatin)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (JJ standard) (NN radioimmunoassay) (NNS techniques))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ _PROT1_) (NNS elements)) (VP (VBN conserved) (PP (IN in) (NP (JJ cereal) (NN _PROT2_) (NNS genes))))) (VP (VBP are) (RB not) (VP (VBN included) (PP (IN in) (NP (NP (DT the) (JJ 5'-upstream) (NN region)) (PP (IN of) (NP (NP (NN Rep1)) (CC or) (NP (NN RepA)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (, ,) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN mitogen) (JJ activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NN kinase)) (ADVP (RB alone))))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB promote) (NP (NN _PROT1_) (NN secretion))))))))))) (, ,) (IN whereas) (S (NP (NP (NN inhibition)) (PP (IN of) (NP (NN MAP) (NN kinase)))) (VP (MD will) (VP (VB reduce) (NP (NN _PROT2_) (NN secretion)) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (NP (NN _PROT_) (NN _PROT_)) (CC or) (NP (NN phosphatidylinositol) (NN 3-kinase))) (VP (VBP are) (ADVP (RB additionally)) (VP (VBN inhibited)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (, ,) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN mitogen) (JJ activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NN kinase)) (ADVP (RB alone))))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB promote) (NP (NN _PROT1_) (NN secretion))))))))))) (, ,) (IN whereas) (S (NP (NP (NN inhibition)) (PP (IN of) (NP (NN MAP) (NN kinase)))) (VP (MD will) (VP (VB reduce) (NP (NN _PROT_) (NN secretion)) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN phosphatidylinositol) (NN 3-kinase))) (VP (VBP are) (ADVP (RB additionally)) (VP (VBN inhibited)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (, ,) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN mitogen) (JJ activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NN kinase)) (ADVP (RB alone))))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB promote) (NP (NN _PROT_) (NN secretion))))))))))) (, ,) (IN whereas) (S (NP (NP (NN inhibition)) (PP (IN of) (NP (NN MAP) (NN kinase)))) (VP (MD will) (VP (VB reduce) (NP (NN _PROT1_) (NN secretion)) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN phosphatidylinositol) (NN 3-kinase))) (VP (VBP are) (ADVP (RB additionally)) (VP (VBN inhibited)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Tolbutamide)) (CC and) (NP (NN diazoxide))) (VP (VBP modulate) (NP (NP (NP (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NN signaling)) (CC and) (NP (NN _PROT2_) (NN secretion))) (PP (IN in) (NP (NNS beta-cells))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (SBAR (IN whether) (S (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide)) (, ,) (SBAR (WHNP (WDT which)) (S (ADJP (ADJP (JJ close)) (CC or) (ADJP (JJ open)) (NP (NP (NP (NP (JJ ATP-sensitive) (NN K)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS channels)) (PRN (-LRB- -LRB-) (NP (NN K) (-LRB- -LRB-) (NN ATP) (-RRB- -RRB-) (NNS channels)) (-RRB- -RRB-))) (, ,) (ADVP (RB respectively))))) (, ,)) (VP (VBP interact) (PP (PP (IN with) (NP (NP (NP (NP (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NNS signals)) (PP (IN in) (NP (NN HIT-T15) (CC and) (NN mouse) (NNS beta-cells))))) (CC and) (PP (IN with) (NP (NP (JJ _PROT2_) (NN _PROT_) (NN secretion)) (PP (IN from) (NP (NN HIT-T15) (NNS cells)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (SBAR (IN whether) (S (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide)) (, ,) (SBAR (WHNP (WDT which)) (S (ADJP (ADJP (JJ close)) (CC or) (ADJP (JJ open)) (NP (NP (NP (NP (JJ ATP-sensitive) (NN K)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS channels)) (PRN (-LRB- -LRB-) (NP (NN K) (-LRB- -LRB-) (NN ATP) (-RRB- -RRB-) (NNS channels)) (-RRB- -RRB-))) (, ,) (ADVP (RB respectively))))) (, ,)) (VP (VBP interact) (PP (PP (IN with) (NP (NP (NP (NP (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NNS signals)) (PP (IN in) (NP (NN HIT-T15) (CC and) (NN mouse) (NNS beta-cells))))) (CC and) (PP (IN with) (NP (NP (JJ _PROT_) (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NN HIT-T15) (NNS cells)))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (SBAR (IN whether) (S (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide)) (, ,) (SBAR (WHNP (WDT which)) (S (ADJP (ADJP (JJ close)) (CC or) (ADJP (JJ open)) (NP (NP (NP (NP (JJ ATP-sensitive) (NN K)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS channels)) (PRN (-LRB- -LRB-) (NP (NN K) (-LRB- -LRB-) (NN ATP) (-RRB- -RRB-) (NNS channels)) (-RRB- -RRB-))) (, ,) (ADVP (RB respectively))))) (, ,)) (VP (VBP interact) (PP (PP (IN with) (NP (NP (NP (NP (JJ _PROT_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NNS signals)) (PP (IN in) (NP (NN HIT-T15) (CC and) (NN mouse) (NNS beta-cells))))) (CC and) (PP (IN with) (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NN HIT-T15) (NNS cells)))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide))) (VP (VBP regulate) (NP (NP (CC both) (NP (NP (NP (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NN signaling)) (CC and) (NP (NN _PROT2_) (NN secretion))) (PP (IN from) (NP (JJ pancreatic) (NNS beta-cells)))) (PP (IN by) (S (VP (VBG modulating) (NP (NP (NP (NN K)) (PRN (-LRB- -LRB-) (NP (NN ATP)) (-RRB- -RRB-))) (NNS channels))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG determining) (NP (JJ voltage-sensitive) (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (NN influx))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (PP (IN for) (NP (DT the) (JJ first) (NN time))) (PP (IN in) (NP (NP (NP (JJ young) (NNS men) (NNS effects)) (PP (IN of) (NP (NP (JJ intravenous) (NNS injections)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD 4x50) (CC or) (CD 100)) (NN microg)) (, ,) (S (NP (NN n)) (VP (JJ =) (NP (CD 9) (CC and) (CD 11)) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN at) (NP (NP (CD 22.00)) (, ,) (NP (CD 23.00)) (, ,) (NP (CD 24.00)) (CC and) (NP (CD 01.00))))))) (VP (VBN compared) (PP (TO to) (NP (NN saline))))) (-RRB- -RRB-)))))) (PP (IN on) (NP (NP (DT the) (JJ sleep) (NN electroencephalogram)) (PRN (-LRB- -LRB-) (NP (NN EEG)) (: ;) (S (VP (VBN recorded) (PP (IN from) (NP (CD 23.00) (TO to) (CD 07.00))))) (-RRB- -RRB-))))) (CC and) (NP (NP (JJ nocturnal) (NN secretion)) (PP (IN of) (NP (NP (NP (JJ adrenocorticotrophic) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN ACTH)) (-RRB- -RRB-))) (, ,) (NP (NN cortisol)) (, ,) (NP (NP (NN growth) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN GH)) (-RRB- -RRB-))) (, ,) (NP (NN prolactin)) (CC and) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN T3)) (VP (MD may) (VP (VB increase) (NP (NP (NN _PROT1_) (NN family) (NN expression)) (ADJP (JJ independent) (PP (IN of) (NP (NN _PROT2_) (NN action)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NNS effects)) (PP (IN on) (NP (NP (JJ pulsatile) (NN gonadotropin) (VBG releasing) (NN hormone) (NN secretion)) (PP (IN from) (NP (DT the) (JJ adult) (NN rat) (NN hypothalamus)))))) (CC and) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (NP (NN cocaine)) (CC and) (NP (NN amphetamine))) (NP (NP (VBN regulated) (NN transcript) (NN peptide)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (VP (VBP [In) (NP (NN Process) (NP (NNP Citation)))) (-RRB- -RSB-))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN feedback) (NN signal)) (PP (TO to) (NP (NP (DT the) (JJ hypothalamic) (NN control)) (PP (IN of) (NP (NN appetite))))))) (PP (IN through) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN secretion)))) (CC and) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN cocaine)) (CC and) (NP (NP (NN amphetamine) (JJ regulated) (NN transcript)) (PRN (-LRB- -LRB-) (NP (NN CART)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD aimed) (PP (IN at) (S (VP (VBG studying) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN CART)) (CC and) (NP (NN _PROT2_)))) (PP (IN on) (NP (NP (DT the) (JJ hypothalamic) (NN control)) (PP (IN of) (NP (DT the) (JJ pituitary-gonadal) (NN system))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN increase)) (PP (IN in) (NP (NN GnRH) (NN pulse) (NN amplitude))) (VP (VBN caused) (PP (IN by) (NP (NN _PROT1_))))) (VP (VBD was) (ADVP (RB totally)) (VP (VBN prevented) (PP (IN by) (NP (NP (NN coincubation)) (PP (IN with) (NP (NP (DT an) (JJ anti-CART) (NN antiserum)) (SBAR (IN whereas) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN affected) (PP (IN by) (NP (NP (NN coincubation)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ Y5-receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (CD 10) (-LRB- -LRB-) (CD -7) (-RRB- -RRB-) (NN M)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP show) (NP (NP (JJ separate) (JJ permissive) (NNS effects)) (PP (IN on) (NP (NP (NN GnRH) (NN secretion)) (PP (IN in) (NP (DT the) (JJ adult) (NN rat) (NN hypothalamus)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN induction)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBN triggered) (PP (IN by) (NP (JJ _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (JJ barley) (NNS embryos))))) (VP (VBZ is) (VP (VBN repressed) (PP (IN by) (NP (NNS sugars))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN glucose)) (VP (VBZ represses) (NP (NN _PROT1_) (NN signalling)) (ADVP (RB late)) (PP (IN along) (NP (DT this) (NN hormone) (NN transduction) (NN pathway))) (, ,) (ADVP (RB downstream) (PP (IN of) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (DT the) (JJ _PROT2_) (JJ transcriptional) (NN activator)) (PRN (-LRB- -LRB-) (NP (NN GAMYB)) (-RRB- -RRB-))))))) (VP (VBN needed) (PP (IN for) (NP (NN _PROT_) (NN induction)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN glucose)) (VP (VBZ represses) (NP (NN _PROT1_) (NN signalling)) (ADVP (RB late)) (PP (IN along) (NP (DT this) (NN hormone) (NN transduction) (NN pathway))) (, ,) (ADVP (RB downstream) (PP (IN of) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (JJ transcriptional) (NN activator)) (PRN (-LRB- -LRB-) (NP (NN GAMYB)) (-RRB- -RRB-))))))) (VP (VBN needed) (PP (IN for) (NP (NN _PROT2_) (NN induction)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN glucose)) (VP (VBZ represses) (NP (NN _PROT_) (NN signalling)) (ADVP (RB late)) (PP (IN along) (NP (DT this) (NN hormone) (NN transduction) (NN pathway))) (, ,) (ADVP (RB downstream) (PP (IN of) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (JJ transcriptional) (NN activator)) (PRN (-LRB- -LRB-) (NP (NN GAMYB)) (-RRB- -RRB-))))))) (VP (VBN needed) (PP (IN for) (NP (NN _PROT2_) (NN induction)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN production)) (PP (IN in) (NP (JJ dose-dependent) (NN fashion))) (PP (IN as) (NP (NN well)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN binding))) (PP (IN in) (NP (JJ human) (NN myometrium)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Carbachol)) (CC and) (NP (NN _PROT1_))) (VP (VBP stimulate) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (JJ _PROT2_) (NNS _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN guinea) (NN pig)) (NN myometrium))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (NP (NN guinea) (NN pig)) (NN myometrium)) (VP (VBN prelabelled) (PP (IN with) (NP (ADJP (NN myo-[2-3H) (-RRB- -RSB-) (JJ inositol))))))) (, ,) (NP (NP (NN carbachol)) (CC and) (NP (NN _PROT1_))) (VP (VBD enhanced) (NP (NP (DT a) (ADJP (ADJP (JJ concentration-dependent)) (CC and) (ADJP (JJ rapid))) (NN release)) (PP (IN of) (NP (NN _PROT2_))) (SBAR (WHNP (WDT which)) (S (VP (VBD preceded) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN IP2)) (CC and) (NP (NN IP1)))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP They)) (VP (VBP are) (VP (VBN needed) (PP (IN for) (NP (NP (DT the) (NN catabolism)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN bile) (NNS acids)) (, ,) (CC and) (NP (NN steroid) (NNS hormones))))))))) (: ;) (S (NP (PRP they)) (VP (VB hydrolyze) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN _PROT2_) (NNS glycosides))) (PP (TO to) (NP (NNS anticarcinogens)))))) (: ;) (CC and) (S (NP (PRP they)) (VP (VB detoxify) (NP (JJ certain) (NNS carcinogens)))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN treatment)) (PP (IN of) (NP (NP (VBN isolated) (NN rat) (NNS diaphragms)) (CC and) (NP (NNS adipocytes)))) (PP (IN with) (NP (NN PIG-P))) (PP (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (NP (JJ other) (NNS agents)) (VP (VBG exerting) (NP (ADJP (RB partially) (JJ _PROT1_)) (NN activity))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (JJ PI-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NN sulfonylurea) (NN glimepiride)))))) (, ,))) (VP (VBD triggered) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (DT the) (JJ caveolar) (NN marker) (NN protein) (NN caveolin))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADVP (RB apparently)) (VP (VBN correlated) (PP (IN with) (NP (NP (NN stimulation)) (PP (IN of) (NP (NN lipogenesis))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Strikingly)) (, ,) (PP (IN in) (NP (NP (NNS adipocytes)) (VP (VBN subjected) (PP (TO to) (NP (NP (JJ combined) (NN trypsin/salt) (NN treatment)) (, ,) (NP (NN PIG-P)) (, ,) (NP (JJ PI-specific) (NN _PROT1_)) (, ,) (CC and) (NP (NN glimepiride))))))) (VP (VBD failed) (S (ADVP (RB completely)) (VP (TO to) (VP (VB provoke) (NP (JJ _PROT2_) (NNS effects)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Neural) (NN site)) (PP (IN of) (NP (NN _PROT1_) (NN influence))) (PP (IN on) (NP (NP (NP (NN neuropeptide) (NN Y)) (NN signaling) (NNS pathways)) (VP (VBG altering) (NP (NP (NN feeding)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN NPY)) (PP (IN in) (NP (DT the) (NNS PVN)))) (VP (VP (VBZ increases) (NP (NN feeding))) (CC and) (VP (VBZ decreases) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-)) (NN activity)) (PP (IN in) (NP (NN brown) (NN fat))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VBZ decreases) (NP (NP (NN NPY) (NN biosynthesis)) (PP (IN in) (NP (DT the) (NN Arc))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB presumably)) (VP (VBZ decreases) (NP (NN PVN) (NN NPY)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Next)) (, ,) (NP (PRP we)) (VP (VBD determined) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ decreases) (NP (NN NPY))) (CC and) (VP (VBZ increases) (NP (NN _PROT2_) (NN gene) (NN expression))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (JJ immunocytochemical) (NNS studies)) (VP (VBD showed) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT1_) (JJ neuronal) (NN MAC) (NN expression)) (PP (IN on) (NP (DT the) (NN SH-SY5Y) (NNS cells)))) (SBAR (IN after) (S (NP (NN CD59)) (VP (VBD was) (VP (VP (VBN removed) (PP (IN by) (NP (NN _PROT2_)))) (CC or) (VP (VBN blocked) (PP (IN by) (NP (CD anti-CD59) (NN antibody))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT_)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT_)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT_)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN food) (NN restriction)) (CC and) (NP (NN _PROT1_) (NN administration))) (PP (IN on) (NP (NP (JJ several) (NNS transcripts)) (VP (VBN involved) (PP (IN in) (NP (NN energy) (NN homeostasis)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (NP (NP (NP (NN _PROT2_)) (, ,) (NP (VBG _PROT_) (NNS _PROT_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-) (CD 1) (, ,) (CD 2) (CC and) (CD 3)) (, ,) (NP (NP (NN lipoprotein) (NN lipase)) (PRN (-LRB- -LRB-) (NP (NN LPL)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ beta3-adrenergic) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN beta3AR)) (-RRB- -RRB-))) (CC and) (NP (JJ hormone-sensitive) (NN lipase))) (PRN (-LRB- -LRB-) (NP (NN HSL)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ epididymal) (-LRB- -LRB-) (NN EWAT) (-RRB- -RRB-) (CC and) (JJ perirenal) (-LRB- -LRB-) (NN PWAT) (-RRB- -RRB-) (JJ white) (NN adipose) (NN tissue)))) (PP (IN in) (NP (NP (CD three) (NNS groups)) (PP (IN of) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN food) (NN restriction)) (CC and) (NP (NN _PROT1_) (NN administration))) (PP (IN on) (NP (NP (JJ several) (NNS transcripts)) (VP (VBN involved) (PP (IN in) (NP (NN energy) (NN homeostasis)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (VBG _PROT2_) (NNS _PROT2_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-) (CD 1) (, ,) (CD 2) (CC and) (CD 3)) (, ,) (NP (NP (NN lipoprotein) (NN lipase)) (PRN (-LRB- -LRB-) (NP (NN LPL)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ beta3-adrenergic) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN beta3AR)) (-RRB- -RRB-))) (CC and) (NP (JJ hormone-sensitive) (NN lipase))) (PRN (-LRB- -LRB-) (NP (NN HSL)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ epididymal) (-LRB- -LRB-) (NN EWAT) (-RRB- -RRB-) (CC and) (JJ perirenal) (-LRB- -LRB-) (NN PWAT) (-RRB- -RRB-) (JJ white) (NN adipose) (NN tissue)))) (PP (IN in) (NP (NP (CD three) (NNS groups)) (PP (IN of) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN food) (NN restriction)) (CC and) (NP (NN _PROT_) (NN administration))) (PP (IN on) (NP (NP (JJ several) (NNS transcripts)) (VP (VBN involved) (PP (IN in) (NP (NN energy) (NN homeostasis)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (VBG _PROT2_) (NNS _PROT2_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-) (CD 1) (, ,) (CD 2) (CC and) (CD 3)) (, ,) (NP (NP (NN lipoprotein) (NN lipase)) (PRN (-LRB- -LRB-) (NP (NN LPL)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ beta3-adrenergic) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN beta3AR)) (-RRB- -RRB-))) (CC and) (NP (JJ hormone-sensitive) (NN lipase))) (PRN (-LRB- -LRB-) (NP (NN HSL)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ epididymal) (-LRB- -LRB-) (NN EWAT) (-RRB- -RRB-) (CC and) (JJ perirenal) (-LRB- -LRB-) (NN PWAT) (-RRB- -RRB-) (JJ white) (NN adipose) (NN tissue)))) (PP (IN in) (NP (NP (CD three) (NNS groups)) (PP (IN of) (NP (NNS rats)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT2_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT2_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT1_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT2_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT1_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT1_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (VP (VBZ is) (ADVP (RBR more)) (VP (VBN expressed) (PP (IN in) (DT the) (NN TEC/TNC) (IN than) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN VP)) (-RRB- -RRB-))))))) (: ;) (S (NP (NP (NP (JJ insulin-like) (NN growth) (NN factor) (CD 2)) (PRN (-LRB- -LRB-) (NP (NN IGF-2)) (-RRB- -RRB-))) (JJ thymic) (NN expression)) (VP (VP (VBZ predominates) (PP (IN over) (NP (NN IGF-1)))) (, ,) (CC and) (VP (ADJP (RB much) (JJR more)) (PP (IN over) (NP (LST (-LRB- _PROT2_) (LS _PROT2_) (-RRB- _PROT2_)) (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN proposed) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (NN self) (NN antigen)) (PP (IN of) (NP (DT the) (JJ neurohypophysial) (NN family)))))))))) (, ,) (CC and) (S (NP (NN IGF-2)) (NP (NP (DT the) (NN self) (NN antigen) (NN precursor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (NP (JJ primary) (JJ microglial) (NNS cultures)) (CC and) (NP (DT the) (NN THP-1) (JJ monocytic) (NN cell) (NN line))) (VP (VBP are) (VP (VBN stimulated) (PP (IN by) (NP (JJ fibrillar) (NN beta-amyloid) (CC and) (NN _PROT1_) (NNS peptides))) (S (VP (TO to) (VP (VB activate) (NP (JJ identical) (NN _PROT2_) (JJ _PROT2_) (JJ inflammatory) (NN signal) (NN transduction) (NNS cascades)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Molecular) (NN characterization)) (PP (IN of) (NP (NP (NN catalytic-subunit) (NN cDNA) (NNS sequences)) (VP (VBG encoding) (NP (NN protein) (NNS phosphatases) (NP (NP (CD 1)) (CC and) (NP (NN 2A)))))))) (CC and) (NP (NP (NN study)) (PP (IN of) (NP (NP (PRP$ their) (NNS roles)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN expression)) (PP (IN in) (NP (NN rice))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (VP (VB understand) (NP (NP (DT the) (JJ molecular) (NN mechanism)) (PP (IN of) (NP (JJ _PROT1_) (NN gene) (NN regulation))))))) (, ,) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (CD three) (NN phosphatase) (NNS inhibitors))) (PP (IN on) (NP (NP (NP (DT the) (NN germination)) (PP (IN of) (NP (NN rice) (NNS seeds)))) (CC and) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN target) (NN gene)) (, ,) (NP (DT the) (NN _PROT2_) (NN gene)) (, ,) (NP (NN Osamy-c)) (, ,))))))) (VP (VBD were) (VP (VBN measured)))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB understand) (NP (NP (DT the) (JJ possible) (NN role)) (PP (IN of) (NP (NN protein) (NNS phosphatases) (NP (NP (CD 1)) (CC and) (NP (NN 2A))))) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))) (, ,) (S (NP (PRP we)) (VP (VBD isolated) (NP (NP (NN cDNA) (NNS clones)) (VP (VBG encoding) (NP (NP (NN protein) (NN phosphatase) (CD 1)) (CC and) (NP (NN protein) (NN phosphatase) (NN 2A))))) (PP (IN from) (NP (DT a) (NN rice) (NN aleurone) (NN cDNA) (NN library))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN protein) (NNS phosphatases) (NP (NP (NN PP1)) (CC or) (NP (NN PP2A)))) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (DT the) (NN rice) (NN _PROT2_) (NN gene)))))) (, ,) (SBAR (IN though) (S (NP (NP (DT the) (NN PP1) (JJ or/and) (NN PP2A) (JJ enzymatic) (NNS activities)) (CONJP (RB as) (RB well) (IN as)) (NP (NN mRNA) (NNS levels))) (VP (VBP do) (RB not) (VP (VB increase) (PP (IN upon) (NP (NN GA3) (NN treatment)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (JJ fetal) (NN guinea) (NN pig) (NN brain) (NNS cultures)))) (ADVP (RB substantially)) (VP (VP (VBD reduced) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (PP (IN in) (NP (DT the) (NN medium)))) (CC but) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN sAPPalpha))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (JJ fetal) (NN guinea) (NN pig) (NN brain) (NNS cultures)))) (ADVP (RB substantially)) (VP (VP (VBD reduced) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (PP (IN in) (NP (DT the) (NN medium)))) (CC but) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN sAPPalpha))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (NN treatment)) (PP (IN of) (NP (JJ fetal) (NN guinea) (NN pig) (NN brain) (NNS cultures)))) (ADVP (RB substantially)) (VP (VP (VBD reduced) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN in) (NP (DT the) (NN medium)))) (CC but) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN sAPPalpha))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))))))) (, ,) (S (S (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT_))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))))))) (, ,) (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))))))) (, ,) (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT_))))))) (, ,) (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT_))))))) (, ,) (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT_))))))) (, ,) (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN tyrosine) (NN phosphorylation)) (PP (IN by) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN rat) (JJ smooth) (NN muscle) (NN cell) (NN line))))))) (, ,) (NP (NN A-10)))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (: :) (NP (NP (NN staurosporine)) (, ,) (NP (NN H7)) (CC and) (NP (NN GF109203X)))) (VP (VBP are) (ADJP (JJ able) (S (VP (TO to) (VP (VB block) (NP (DT the) (JJ _PROT2_) (NN phosphorylation))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB upstream) (PP (IN of) (NP (DT the) (NN phosphorylation)))) (, ,) (NP (NP (DT a) (NN motion)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN supported) (PP (IN by) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (JJ _PROT2_) (NN phosphorylation)) (VP (VBD was) (VP (VBN downregulated) (PP (IN by) (NP (NN phorbol) (NNS esters)))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Aggregated) (NN beta) (NN _PROT1_) (NN peptide) (NN 1-40)) (VP (VBZ decreases) (NP (NP (NN Ca2+-)) (CC and) (NP (JJ cholinergic) (JJ receptor-mediated) (NN phosphoinositide) (NN degradation))) (PP (IN by) (NP (NP (NN alteration)) (PP (IN of) (NP (NP (NN membrane)) (CC and) (NP (JJ cytosolic) (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NN brain) (NN cortex)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NP (JJ full-length) (NN _PROT1_) (NN beta) (NN protein)) (, ,) (NP (NP (NP (NN A)) (PRN (-LRB- -LRB-) (NP (NN beta)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN 1-40)) (-RRB- -RRB-))) (, ,))) (PP (IN on) (NP (NP (JJ phosphoinositide-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN investigated) (PP (IN in) (NP (NP (NP (JJ synaptic) (NN plasma) (NNS membranes)) (PRN (-LRB- -LRB-) (NP (NN SPM)) (-RRB- -RRB-))) (CC and) (NP (NP (NN cytosol)) (VP (VBN prepared) (PP (IN from) (NP (NP (DT the) (JJ cerebral) (NN cortex)) (PP (IN of) (NP (JJ adult) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Aggregated) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (ADVP (RB also)) (VP (VBD decreased) (ADVP (RB significantly)) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN diacylglycerol)))))) (, ,) (NP (NP (DT the) (NN product)) (PP (IN of) (NP (NN _PROT2_)))))) |ET|
+1 |BT| (S1 (S (NP (DT This)) (ADVP (RB additionally)) (VP (VBZ supports) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))) (PP (IN on) (NP (ADJP (ADJP (JJ membrane-bound)) (CC and) (ADJP (JJ cytosolic))) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NP (NP (DT the) (JJ basal) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NN SPM)))) (CC and) (NP (NP (DT the) (NN enzyme) (NN activity)) (VP (VBN regulated) (PP (IN through) (NP (JJ cholinergic) (NNS receptors))))))))) |ET|
-1 |BT| (S1 (S (NP (CD Ten) (NN _PROT1_) (NNS _PROT1_)) (VP (VBP have) (VP (VBN been) (VP (VBN assayed) (PP (IN for) (NP (PRP$ their) (NN ability) (S (VP (TO to) (VP (VB phosphorylate) (ADVP (FW in) (FW vitro)) (NP (NP (NP (DT the) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN 25-242)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN rbPrP)) (-RRB- -RRB-))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN With) (NN regard) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NN phosphorylation)) (VP (VBZ occurs) (PP (IN at) (NP (NN Ser) (CD 154))) (PP (IN with) (NP (NP (DT a) (NN stoichiometry)) (PP (IN of) (NP (QP (RB about) (CD 0.1)) (NN mol) (NN phosphate/mol) (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN doubled) (PP (IN by) (NP (NP (JJ mild) (NN heat) (NN treatment)) (PP (IN of) (NP (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN With) (NN regard) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NN phosphorylation)) (VP (VBZ occurs) (PP (IN at) (NP (NN Ser) (CD 154))) (PP (IN with) (NP (NP (DT a) (NN stoichiometry)) (PP (IN of) (NP (QP (RB about) (CD 0.1)) (NN mol) (NN phosphate/mol) (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN doubled) (PP (IN by) (NP (NP (JJ mild) (NN heat) (NN treatment)) (PP (IN of) (NP (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN With) (NN regard) (TO to) (NP (NN _PROT_))) (, ,) (NP (NN phosphorylation)) (VP (VBZ occurs) (PP (IN at) (NP (NN Ser) (CD 154))) (PP (IN with) (NP (NP (DT a) (NN stoichiometry)) (PP (IN of) (NP (QP (RB about) (CD 0.1)) (NN mol) (NN phosphate/mol) (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN doubled) (PP (IN by) (NP (NP (JJ mild) (NN heat) (NN treatment)) (PP (IN of) (NP (NN _PROT2_)))))))))))))) |ET|
+1 |BT| (S1 (S (IN In) (S (NP (NP (DT the) (JJ fasting) (NN state)) (NN _PROT1_) (NN expression)) (VP (VBD correlated) (ADVP (RB inversely)) (PP (IN with) (NP (NP (NP (NN body) (NN mass) (NN index)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.45)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.026)))) (-RRB- -RRB-))) (, ,) (NP (NP (JJ percent) (NN body) (NN fat)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.41)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.05)))) (-RRB- -RRB-))) (, ,) (NP (NP (NN plasma) (NN insulin)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.47)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.02)))) (-RRB- -RRB-))) (, ,) (NP (NP (JJ epigastric) (JJ venous) (JJ fatty) (NNS acids)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.45)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.04)))) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.50)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.018)))) (-RRB- -RRB-)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN expression)) (VP (VBD remained) (ADJP (RB inversely) (JJ related) (PP (IN with) (NP (NN plasma) (NN _PROT2_)))) (PP (IN after) (S (VP (VBG controlling) (PP (IN for) (NP (JJ percent) (NN body)))))) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (ADJP (JJ =) (NP (CD -0.45)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.038)))) (-RRB- -RRB-))))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (LST (LS 1) (-RRB- -RRB-)) (NP (NP (NN _PROT1_) (NN messenger) (NN ribonucleic) (NN acid) (NN expression)) (PP (IN in) (NP (JJ sc) (NN adipose) (NN tissue)))) (VP (VP (VBZ is) (ADJP (RB inversely) (JJ related) (PP (TO to) (NP (NN adiposity))))) (CC and) (VP (ADVP (RB independently)) (VBN linked) (PP (TO to) (NP (JJ local) (NN plasma) (NN _PROT2_) (NNS levels)))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (RB not) (ADVP (RB acutely)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN food) (NN intake)) (, ,) (NP (NN insulin)) (, ,) (CC or) (NP (JJ fatty) (NNS acids))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (LST (LS 1) (-RRB- -RRB-)) (NP (NP (NN _PROT1_) (NN messenger) (NN ribonucleic) (NN acid) (NN expression)) (PP (IN in) (NP (JJ sc) (NN adipose) (NN tissue)))) (VP (VP (VBZ is) (ADJP (RB inversely) (JJ related) (PP (TO to) (NP (NN adiposity))))) (CC and) (VP (ADVP (RB independently)) (VBN linked) (PP (TO to) (NP (JJ local) (NN plasma) (NN _PROT_) (NNS levels)))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (RB not) (ADVP (RB acutely)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN food) (NN intake)) (, ,) (NP (NN insulin)) (, ,) (CC or) (NP (JJ fatty) (NNS acids))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (LST (LS 1) (-RRB- -RRB-)) (NP (NP (NN _PROT_) (NN messenger) (NN ribonucleic) (NN acid) (NN expression)) (PP (IN in) (NP (JJ sc) (NN adipose) (NN tissue)))) (VP (VP (VBZ is) (ADJP (RB inversely) (JJ related) (PP (TO to) (NP (NN adiposity))))) (CC and) (VP (ADVP (RB independently)) (VBN linked) (PP (TO to) (NP (JJ local) (NN plasma) (NN _PROT1_) (NNS levels)))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (RB not) (ADVP (RB acutely)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN food) (NN intake)) (, ,) (NP (NN insulin)) (, ,) (CC or) (NP (JJ fatty) (NNS acids))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NN obesity)) (CC and) (NP (JJ menopausal) (NN status)))) (PP (IN on) (NP (NP (NP (NN serum) (NN _PROT1_)) (, ,) (NP (NN cholecystokinin)) (, ,) (NP (NN galanin)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (NNS levels)))))) |ET|
-1 |BT| (S1 (S (NP (NN Obesity)) (VP (VP (VBZ occurs) (PP (IN in) (NP (NP (CD 60) (NN %)) (PP (IN of) (NP (NP (NNS women)) (PP (IN after) (NP (NN menopause)))))))) (CC and) (VP (VBZ is) (VP (VBN characterized) (PP (IN by) (NP (NP (DT an) (NN excess)) (PP (IN of) (NP (NN adipose) (NN tissue)))))))) (SBAR (WHNP (WDT that)) (S (VP (VBZ depends) (PP (IN on) (NP (JJ several) (ADJP (ADJP (ADJP (JJ orexigenic)) (PRN (-LRB- -LRB-) (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (VP (VBZ stimulates) (NP (NN carbohydrate) (NN ingestion)))) (, ,) (S (NP (NN galanin)) (VP (VBZ stimulates) (NP (JJ fat) (NN intake))))) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ anorectic)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-)))) (-RRB- -RRB-)))) (NNS factors)))))))) |ET|
+1 |BT| (S1 (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN insulin))) (VP (MD can) (VP (VB reduce) (NP (NP (JJ hypothalamic) (NN _PROT2_) (NN production)) (CC and) (NP (NN secretion))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (NP (NP (JJ basal) (NNS levels)) (PP (IN of) (NP (NP (NP (NN serum) (NN _PROT1_)) (, ,) (NP (NN CCK)) (, ,) (NP (NN galanin)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (CD 16) (JJ non-obese) (JJ premenopausal) (NNS women))) (, ,) (PP (IN in) (NP (NP (CD 15) (JJ obese) (JJ premenopausal) (NNS women)) (PRN (-LRB- -LRB-) (NP (NN body) (NN mass) (NN index) (-LRB- -LRB-) (NN BMI) (-RRB- -RRB-) (QP (CD 34.6) (CC +/-) (CD 1.3)) (NN SD)) (-RRB- -RRB-)))) (CC and) (PP (IN in) (NP (NP (CD ten) (JJ obese) (JJ postmenopausal) (NNS women)) (PRN (-LRB- -LRB-) (NP (NN BMI) (CD 34.7) (CC +/-) (CD 1.5) (NN SD)) (-RRB- -RRB-)))))))))) (S (VP (TO to) (VP (VB determine) (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (NN obesity)) (, ,) (NP (NN menopause)) (CC and) (NP (DT these) (NNS neuropeptides))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (ADJP (RB Significantly) (VBN increased)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN galanin))) (NNS levels)) (PP (IN in) (NP (NP (JJ postmenopausal) (JJ obese) (NNS women)) (VP (VBN coupled) (PP (IN with) (NP (VBN decreased) (NN _PROT2_) (NNS levels))))))) (VP (VBD revealed) (NP (NP (DT some) (NNS changes)) (PP (IN in) (NP (NP (DT the) (NNS neuropeptides)) (VP (VBG regulating) (NP (JJ eating) (NN behavior))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB be) (NP (NP (DT the) (NN reason)) (PP (IN for) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (JJ postmenopausal) (NN obesity)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT A) (NN loop) (NN system)) (VP (VBZ exists) (PP (IN between) (NP (NP (NP (JJ hypothalamic) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC and) (NP (JJ peripheral) (NN adipose) (NN tissue) (NN _PROT2_)))) (S (VP (TO to) (VP (VB maintain) (NP (JJ normal) (NN body) (NN homeostasis)))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN infused) (NP (NN i.c.v.)) (PP (TO to) (NP (JJ normal) (NNS rats))) (S (VP (TO to) (VP (VB mimic) (NP (PRP$ its) (JJ central) (NNS effects)))))))) (, ,) (S (NP (NN _PROT1_)) (VP (VBZ decreases) (NP (NP (NN _PROT2_) (NNS levels)) (, ,) (ADVP (RB thus)) (NP (NP (NN food) (NN intake)) (CC and) (NP (NN body) (NN weight)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Circadian) (NNS fluctuations)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS levels)))) (VP (VBP maintain) (NP (JJ normal) (NN body) (NN homeostasis))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBZ increases) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NNS _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NP (NN UCP-1)) (, ,) (NP (CD -2)) (, ,) (NP (CD -3))) (-RRB- -RRB-))) (CC and) (VP (ADVP (RB thus)) (NP (NN energy) (NN dissipation)))))) |ET|
+1 |BT| (S1 (S (PP (VBN Compared) (PP (IN with) (NP (DT the) (JJ wild) (NN type)))) (, ,) (NP (NP (NN _PROT1_) (NN induction)) (PP (IN of) (NP (JJ _PROT2_) (NN activity))) (PP (IN in) (NP (NP (NN aleurone) (NNS cells)) (PP (IN of) (NP (NN d1)))))) (VP (VBD was) (ADVP (RB greatly)) (VP (VBN reduced))))) |ET|
+1 |BT| (S1 (S (PP (JJ Relative) (TO to) (NP (DT the) (JJ wild) (NN type))) (, ,) (NP (NP (DT the) (NN _PROT1_) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-) (JJ -treated) (NN aleurone) (NN layer)) (PP (IN of) (NP (NN d1)))) (VP (VBD had) (NP (NP (JJR lower) (NN expression)) (PP (IN of) (NP (NN Ramy1A))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (NP (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN OsGAMYB))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (DT a) (JJ _PROT_) (JJ transcriptional) (NN factor))))) (, ,)) (CC and) (NP (NP (DT no) (NN increase)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN Ca)) (PRN (-LRB- -LRB-) (NP (CD 2)) (CC +) (-RRB- -RRB-))) (NN -ATPase)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (JJ Relative) (TO to) (NP (DT the) (JJ wild) (NN type))) (, ,) (NP (NP (DT the) (NN _PROT1_) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-) (JJ -treated) (NN aleurone) (NN layer)) (PP (IN of) (NP (NN d1)))) (VP (VBD had) (NP (NP (JJR lower) (NN expression)) (PP (IN of) (NP (NN Ramy1A))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (NP (NP (NN _PROT_)) (, ,) (CC and) (NP (NN OsGAMYB))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (DT a) (JJ _PROT2_) (JJ transcriptional) (NN factor))))) (, ,)) (CC and) (NP (NP (DT no) (NN increase)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN Ca)) (PRN (-LRB- -LRB-) (NP (CD 2)) (CC +) (-RRB- -RRB-))) (NN -ATPase)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (JJ Relative) (TO to) (NP (DT the) (JJ wild) (NN type))) (, ,) (NP (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-) (JJ -treated) (NN aleurone) (NN layer)) (PP (IN of) (NP (NN d1)))) (VP (VBD had) (NP (NP (JJR lower) (NN expression)) (PP (IN of) (NP (NN Ramy1A))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN OsGAMYB))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (DT a) (JJ _PROT2_) (JJ transcriptional) (NN factor))))) (, ,)) (CC and) (NP (NP (DT no) (NN increase)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN Ca)) (PRN (-LRB- -LRB-) (NP (CD 2)) (CC +) (-RRB- -RRB-))) (NN -ATPase)))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (PP (IN in) (DT the) (NN presence) (IN of) (NP (JJ high) (NN _PROT1_) (NNS concentrations))) (, ,) (NP (NN _PROT2_) (NN induction)) (VP (VBD occurred) (ADVP (RB even)) (PP (IN in) (NP (NN d1)))))) |ET|
+1 |BT| (S1 (S (NP (PDT All) (DT these) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN d1)) (VP (VBZ affects) (NP (NP (NP (DT a) (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN pathway)))) (, ,) (NP (NP (RB namely) (DT the) (NN induction)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN aleurone) (NN layer)))) (CC and) (NP (NN internode) (NN elongation))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Arcuate) (NN nucleus) (NN _PROT1_) (NN mRNA)) (VP (VBD increased) (PP (IN in) (NP (NP (NNS rats)) (PP (IN given) (NP (JJ protein-free) (NN diet))))) (, ,) (S (VP (VBG correlating) (PP (IN with) (NP (NP (NN _PROT2_)) (CONJP (RB rather) (IN than)) (NP (VBN decreased) (NN feeding))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Granulosa) (NNS cells)) (VP (VBD were) (VP (VP (VBN isolated) (PP (IN from) (NP (JJ bovine) (JJ preovulatory) (NNS follicles)))) (CC and) (VP (VBN cultured) (PP (IN for) (NP (NP (CD 3) (NNS days)) (PP (IN with) (CC or) (PP (IN without) (NP (NN _PROT1_)))))) (PP (IN in) (NP (NP (NP (NP (NN medium)) (VP (VBN supplemented) (PP (IN with) (NP (CC either) (NP (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microgram/ml)) (-RRB- -RRB-))) (CC +) (NP (ADJP (CD 1) (NN %)) (NP (NP (JJ fetal) (NN calf) (NN serum)) (PRN (-LRB- -LRB-) (NP (NN FCS)) (-RRB- -RRB-))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ maintains) (NP (JJ basal) (NN estradiol) (NN secretion))))) (, ,)) (CC or) (NP (NP (JJ low) (NNS doses)) (PP (IN of) (NP (NP (NN FSH)) (PRN (-LRB- -LRB-) (NP (QP (CD 1) (CC and) (CD 2)) (NN ng/ml)) (-RRB- -RRB-))))))))) (CC +) (NP (ADJP (CD 1) (NN %)) (NN FCS))) (, ,) (NP (NP (DT a) (NN culture) (NN condition)) (SBAR (WHNP (WDT that)) (S (VP (VBZ maximizes) (NP (NP (NNS effects)) (PP (IN of) (NP (NN FSH))) (PP (IN on) (NP (NN estradiol) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Wortmannin)) (VP (VBZ converts) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))) (PP (IN from) (NP (DT an) (JJ antilipolytic))) (PP (TO to) (NP (NP (DT a) (JJ lipolytic) (NN agent)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN forskolin)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NNS studies)) (VP (VBD compared) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN rat) (NNS adipocytes)))) (PP (IN with) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN peroxovanadate)))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP mimic) (NP (NP (DT some) (NNS effects)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NNS studies)) (VP (VBD compared) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN rat) (NNS adipocytes)))) (PP (IN with) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN peroxovanadate)))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP mimic) (NP (NP (DT some) (NNS effects)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NNS studies)) (VP (VBD compared) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN rat) (NNS adipocytes)))) (PP (IN with) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN peroxovanadate)))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP mimic) (NP (NP (DT some) (NNS effects)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ antilipolytic) (NNS effects)) (PP (IN of) (NP (NP (NN peroxovanadate)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN unaffected) (PP (IN by) (NP (ADJP (CD 500) (NN nmol/L)) (NN wortmannin)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD blocked) (NP (NP (DT the) (JJ antilipolytic) (NN action)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP provide) (NP (NP (JJ additional) (NN support)) (PP (IN for) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN peroxovanadate))) (VP (VBP affect) (NP (NN adipose) (NN tissue) (NN metabolism)) (PP (IN by) (NP (NP (NNS mechanisms)) (ADJP (RB distinctly) (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN involved) (PP (IN in) (NP (NN _PROT2_) (NN action)))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN effect)) (VP (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (NP (CD 10) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN M)) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN concentration)) (PP (ADVP (RB clearly)) (IN above) (NP (NP (DT the) (JJ normal) (JJ physiological) (NN range)) (PP (IN of) (NP (NN _PROT1_) (NNS concentrations)))))) (-RRB- -RRB-))))))) (CC and) (VP (VBZ involves) (NP (DT the) (NN V2) (NN receptor) (NN pathway)) (, ,) (SBAR (IN while) (S (NP (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (CC or) (NP (NP (NNS changes)) (PP (IN in) (NP (JJ intracellular) (NN calcium))))) (VP (VBP are) (NP (JJ ineffective))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN effect)) (VP (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (NP (CD 10) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN M)) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN concentration)) (PP (ADVP (RB clearly)) (IN above) (NP (NP (DT the) (JJ normal) (JJ physiological) (NN range)) (PP (IN of) (NP (NN _PROT1_) (NNS concentrations)))))) (-RRB- -RRB-))))))) (CC and) (VP (VBZ involves) (NP (DT the) (NN V2) (NN receptor) (NN pathway)) (, ,) (SBAR (IN while) (S (NP (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (CC or) (NP (NP (NNS changes)) (PP (IN in) (NP (JJ intracellular) (NN calcium))))) (VP (VBP are) (NP (JJ ineffective))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN effect)) (VP (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (NP (CD 10) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN M)) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN concentration)) (PP (ADVP (RB clearly)) (IN above) (NP (NP (DT the) (JJ normal) (JJ physiological) (NN range)) (PP (IN of) (NP (NN _PROT_) (NNS concentrations)))))) (-RRB- -RRB-))))))) (CC and) (VP (VBZ involves) (NP (DT the) (NN V2) (NN receptor) (NN pathway)) (, ,) (SBAR (IN while) (S (NP (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (CC or) (NP (NP (NNS changes)) (PP (IN in) (NP (JJ intracellular) (NN calcium))))) (VP (VBP are) (NP (JJ ineffective))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN EGFR) (VBG overexpressing) (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ leads) (PP (TO to) (NP (NP (NP (DT a) (ADJP (ADJP (CD 3.4)) (CC +/-) (ADJP (JJ 1.2-fold))) (NN stimulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN activity)) (PP (IN over) (NP (JJ basal) (NNS levels)))))) (CC vs.) (NP (NP (QP (RB only) (CD 1.06) (CC +/-) (CD 0.01-fold)) (NN stimulation)) (PP (IN by) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN Despite) (NP (NP (DT the) (JJ low) (NNS levels)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT2_) (NN activity))))) (, ,) (NP (JJ _PROT_) (NN glucose) (NN transport) (NN activity)) (VP (VBD was) (ADVP (RB similarly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN U73122)) (PRN (-LRB- -LRB-) (NP (QP (CD 55.9) (CC +/-) (CD 13.1)) (NN %) (NN inhibition)) (-RRB- -RRB-)))))))) |ET|
-1 |BT| (S1 (S (PP (IN Despite) (NP (NP (DT the) (JJ low) (NNS levels)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT_) (NN activity))))) (, ,) (NP (JJ _PROT2_) (NN glucose) (NN transport) (NN activity)) (VP (VBD was) (ADVP (RB similarly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN U73122)) (PRN (-LRB- -LRB-) (NP (QP (CD 55.9) (CC +/-) (CD 13.1)) (NN %) (NN inhibition)) (-RRB- -RRB-)))))))) |ET|
-1 |BT| (S1 (S (PP (IN Despite) (NP (NP (DT the) (JJ low) (NNS levels)) (PP (IN of) (NP (JJ _PROT_) (NN _PROT1_) (NN activity))))) (, ,) (NP (JJ _PROT2_) (NN glucose) (NN transport) (NN activity)) (VP (VBD was) (ADVP (RB similarly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN U73122)) (PRN (-LRB- -LRB-) (NP (QP (CD 55.9) (CC +/-) (CD 13.1)) (NN %) (NN inhibition)) (-RRB- -RRB-)))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN activation)))) (VP (VBD did) (RB not) (VP (VB impair) (NP (CC either) (NP (NP (NP (NN EGF-)) (CC or) (NP (JJ _PROT2_) (NN activation))) (PP (IN of) (NP (NN glycogen) (NN synthase)))) (CC or) (NP (NP (NN incorporation)) (PP (IN of) (NP (NN glucose))) (PP (IN into) (NP (NN lipid))))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (CC both) (NP (NN EGF-)) (CC and) (NP (JJ _PROT_) (NN glucose) (NN disposal))) (VP (MD can) (VP (VB be) (ADJP (JJ independent) (PP (IN of) (NP (JJ GLUT4-mediated) (NN glucose) (NN transport)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN activation)))) (VP (VBD did) (RB not) (VP (VB impair) (NP (CC either) (NP (NP (NP (NN EGF-)) (CC or) (NP (JJ _PROT_) (NN activation))) (PP (IN of) (NP (NN glycogen) (NN synthase)))) (CC or) (NP (NP (NN incorporation)) (PP (IN of) (NP (NN glucose))) (PP (IN into) (NP (NN lipid))))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (CC both) (NP (NN EGF-)) (CC and) (NP (JJ _PROT2_) (NN glucose) (NN disposal))) (VP (MD can) (VP (VB be) (ADJP (JJ independent) (PP (IN of) (NP (JJ GLUT4-mediated) (NN glucose) (NN transport)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT_) (NN activation)))) (VP (VBD did) (RB not) (VP (VB impair) (NP (CC either) (NP (NP (NP (NN EGF-)) (CC or) (NP (JJ _PROT1_) (NN activation))) (PP (IN of) (NP (NN glycogen) (NN synthase)))) (CC or) (NP (NP (NN incorporation)) (PP (IN of) (NP (NN glucose))) (PP (IN into) (NP (NN lipid))))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (CC both) (NP (NN EGF-)) (CC and) (NP (JJ _PROT2_) (NN glucose) (NN disposal))) (VP (MD can) (VP (VB be) (ADJP (JJ independent) (PP (IN of) (NP (JJ GLUT4-mediated) (NN glucose) (NN transport)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN diminution)) (PP (IN of) (NP (NP (NN glucose) (NN transport)) (ADJP (JJ secondary) (PP (TO to) (NP (NP (NN inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN activity))))))))) (VP (VBD was) (VP (VBN reflected) (PP (IN by) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NN GLUT4) (NN translocation)) (PP (TO to) (NP (DT the) (NN plasma) (NN membrane))))))) (PP (IN upon) (NP (CC either) (NP (NN EGF)) (CC or) (NP (NN _PROT2_) (NN stimulation)))))))) |ET|
+1 |BT| (S1 (S (NP (JJ _PROT1_) (JJ male) (NNS rats)) (VP (VBD had) (NP (NP (NP (VBN increased) (VBG circulating) (NNS levels)) (PP (IN of) (NP (NN cholecystokinin)))) (, ,) (NP (NP (DT a) (NN tendency)) (PP (TO to) (NP (NP (VBN increased) (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ =) (CD 0.066)) (-RRB- -RRB-))))))) (, ,) (CC and) (NP (NP (ADJP (RB relatively) (JJR more)) (NN adipose) (NN tissue)) (PP (IN in) (NP (DT the) (NP (NN thigh)) (CC and) (NP (JJ interscapular) (NN region)))))) (, ,) (PP (VBN compared) (PP (IN with) (NP (NNS controls))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (JJ renal) (JJ epithelial) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (DT a) (JJ biphasic) (NN increase)) (PP (IN in) (NP (NN diacylglycerol) (NN generation))) (, ,) (VP (VBN characterized) (PP (IN by) (NP (NP (DT an) (JJ initial) (JJ rapid) (NN rise)) (CC and) (RB then) (NP (DT a) (JJ sustained) (NN elevation)) (, ,) (CC and) (NP (NN _PROT2_) (NN activation))))) (, ,) (VP (VBN reflected) (PP (IN by) (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NP (DT a) (JJ specific) (ADJP (NP (CD 80) (NN kDa)) (VBN myristoylated)) (JJ alanine-rich) (NN PKC) (NN substrate)) (PRN (-LRB- -LRB-) (NP (NN MARCKS)) (-RRB- -RRB-))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP argue) (SBAR (SBAR (IN that) (S (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -dependent)) (NN _PROT1_)) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NN _PROT2_))))))))) (, ,) (CC and) (SBAR (IN that) (S (PP (IN of) (NP (JJ other) (NNS agonists))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP stimulate) (NP (NN sodium) (NN transport))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN During) (NP (NN wk) (CD 6))) (, ,) (S (S (NP (NP (NN milk) (NN yield)) (CC and) (NP (NP (JJ dry) (NN matter) (NN intake)) (PRN (-LRB- -LRB-) (NP (NN DMI)) (-RRB- -RRB-)))) (VP (VBD were) (VP (VBN recorded) (ADVP (RB daily))))) (, ,) (CC and) (S (NP (NP (NN plasma) (NNS concentrations)) (PP (IN of) (NP (NP (NN glucose)) (, ,) (NP (JJ nonesterified) (JJ fatty) (NNS acids)) (, ,) (NP (NN urea)) (, ,) (NP (NN protein)) (, ,) (NP (NN growth) (NN hormone)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (JJ insulin-like) (NN growth) (NN factor) (CD I)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN prolactin))))) (VP (VBD were) (VP (VBN determined))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Concurrent) (NN decrease)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN immunoreactivity)))) (PP (IN during) (NP (DT the) (JJ light) (NN phase))) (PP (IN in) (NP (DT the) (JJ vole) (JJ suprachiasmatic) (NN nucleus)))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Mean) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (JJ _PROT2_) (NNS neurons)))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NP (DT the) (JJ suprachiasmatic) (NN nucleus)) (PP (IN of) (NP (NP (JJ common) (NNS voles)) (, ,) (VP (VBN entrained) (PP (TO to) (NP (DT a) (ADJP (CD 12:12) (NN h)) (NN light-dark) (-LRB- -LRB-) (NN LD) (-RRB- -RRB-) (NN cycle)))))))) (, ,) (PP (IN at) (NP (NP (DT the) (NN beginning)) (PP (IN of) (NP (NP (NP (NP (DT the) (JJ light) (NN period)) (PRN (-LRB- -LRB-) (NP (NN zeitgeber) (NN time) (CD zero)) (-RRB- -RRB-))) (CC and) (NP (NP (CD 6) (NN h)) (ADVP (RB later)))) (PRN (-LRB- -LRB-) (NP (NN zeitgeber) (NN time) (CD six)) (-RRB- -RRB-)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NN zeitgeber) (NN time) (CD zero))) (, ,) (NP (NP (JJ mean) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (JJ _PROT2_) (JJ immunoreactive) (NNS neurons)))) (VP (VBD were) (NP (NP (CD 2194)) (CC and) (NP (CD 9897))) (, ,) (ADVP (RB respectively))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN distribution)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (NNS cells)) (PP (IN in) (NP (DT the) (NNS SCN)))))) (VP (VBD overlapped) (PP (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))) (PP (IN in) (NP (DT both) (NNS species)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Species) (NNS differences)) (PP (IN in) (NP (NP (DT the) (NN location)) (PP (IN of) (NP (DT the) (JJ Ca2+-dependent) (NN _PROT1_) (NNS isoforms)))))) (VP (VBP suggest) (NP (NP (NP (NNS differences)) (PP (IN in) (NP (NP (NN function)) (PP (JJ such) (IN as) (NP (NP (DT the) (VBG relaying)) (PP (IN of) (NP (ADJP (ADJP (JJ photic)) (CC or) (ADJP (JJ non-photic))) (NN information))) (PP (TO to) (NP (DT the) (JJ clock) (NN mechanism)))))))) (, ,) (CC or) (NP (NP (DT the) (NN synchronization)) (PP (IN of) (NP (NN _PROT2_) (NNS neurons)))) (CC and) (NP (PRP$ their) (JJ subsequent) (NN output) (NNS signals)))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (CD two) (NNS groups)) (VP (VBD were) (ADJP (JJ similar)) (PP (IN in) (NP (NP (PRP$ their) (NN morning) (NN thyroxin)) (, ,) (NP (NN triiodothyronine)) (, ,) (NP (NN TSH)) (, ,) (NP (NN estradiol) (, ,) (NN cortisol) (, ,) (NN gastrin) (, ,) (NN cholecystokinin) (, ,) (NN somatostatin) (, ,) (NN _PROT1_) (, ,) (NN _PROT2_) (CC and) (NN IGF-1) (NNS levels))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (VBN deduced) (NN consensus)) (ADVP (RB closely)) (VP (VBD resembled) (NP (NP (NN _PROT1_) (NN response) (NNS elements)) (PP (IN in) (NP (NN _PROT2_) (NNS promoters))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Phorbol) (NN myristate) (NN acetate)) (PRN (-LRB- -LRB-) (NP (NN TPA)) (-RRB- -RRB-))) (, ,) (NP (NP (DT an) (NN activator)) (PP (IN of) (NP (NN _PROT1_)))) (, ,)) (VP (VP (VBD elicited) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (NN MAPK) (NN activity))))) (, ,) (CC but) (VP (VBD did) (RB not) (ADVP (RB further)) (VP (VB influence) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (JJ _PROT2_) (NN MAPK) (NN activity)))))))) (: ;) (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (DT the) (NN extent)) (PP (IN of) (NP (NN CaMKII) (NN activation)))) (VP (VBD was) (VP (VBN attenuated) (PP (IN by) (NP (NN TPA)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT A) (JJ neurotoxic) (NN fragment)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NP (NNP Abeta) (CD 25-35)) (, ,) (VP (VBN incubated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN Ca2+))))))) (, ,)) (VP (VBD increased) (ADVP (RB significantly)) (NP (NP (DT the) (NN _PROT2_) (NN activity)) (PP (IN of) (NP (JJ normoxic) (NN brain))))))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (PRP$ its) (JJ non-aggregated) (NN form))) (, ,) (NP (NNP _PROT1_) (CD _PROT1_)) (VP (VBZ activates) (NP (NN _PROT2_)) (PP (CC but) (IN in) (NP (DT the) (VBN aggregated) (NN form))))) (S (NP (DT the) (JJ enzymatic) (NN activity)) (VP (VBD decreased))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_) (CD _PROT1_)) (VP (VP (VBZ exerts) (NP (DT a) (JJ similar) (NN effect)) (PP (IN on) (NP (NP (DT the) (JJ membrane-bound) (NN _PROT2_)) (PP (IN from) (NP (JJ normoxic) (NN brain)))))) (CC or) (VP (VBN subjected) (PP (TO to) (NP (NN ischemia) (NN reperfusion) (NN injury))))))) |ET|
+1 |BT| (S1 (S (NP (NN Ischemia-reperfusion) (NN injury)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ _PROT1_) (NNS alterations)) (PP (IN of) (NP (JJ synaptic) (NN plasma) (JJ membrane-bound) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN peptide) (CD 25-35)) (VP (VBZ modulates) (NP (NP (NN hydrolysis)) (PP (IN of) (NP (NNS phosphoinositides)))) (PP (IN by) (NP (NP (NN membrane) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (PP (IN of) (NP (JJ adult) (NN brain) (NN cortex))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN Fresh-water-soluble) (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD activated) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NN SPM)))) (ADVP (RB markedly)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold))))) (, ,) (CC but) (S (NP (DT this) (NN effect)) (VP (VBD was) (ADJP (JJ absent) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (ADJP (CD 2) (NN mM)) (NN CaCl2)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT2_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT1_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT1_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ aggregated) (NN form)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)))) (ADVP (RB significantly)) (VP (VBD inhibited) (NP (NN _PROT2_)) (PP (ADVP (RB only)) (IN in) (DT the) (NN presence) (IN of) (NP (JJ endogenous) (NN CaCl2)))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Hypothalamic) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (JJ neuroendocrine) (NN regulation)) (PP (IN by) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Relationship)) (PP (IN among) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN galanin))) (PP (PP (IN in) (NP (JJ young) (NNS women))) (CC and) (PP (IN in) (NP (JJ postmenopausal) (NNS women))))))) (VP (VBD [see) (NP (NNS comments))) (-RRB- -RSB-))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB determine) (SBAR (IN whether) (S (NP (JJ hormonal) (NN status)) (VP (MD may) (VP (VB affect) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NN galanin)) (, ,) (CC and) (NP (NN _PROT2_) (NN release))) (PP (PP (IN in) (NP (JJ postmenopausal) (NNS women))) (CC and) (PP (IN in) (NP (JJ young) (NNS women))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (PRP$ Our) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NNS differences)) (VP (VBZ is) (NP (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN galanin))) (PP (IN between) (NP (NP (JJ postmenopausal) (NNS women)) (CC and) (NP (JJ young) (NNS women))))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (PP (TO to) (NP (NN body) (NN mass) (NN index))) (CONJP (RB rather) (IN than)) (PP (TO to) (NP (NP (NNS differences)) (PP (IN in) (NP (JJ hormonal) (NN status))))))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (JJR higher) (NN _PROT_) (NNS levels)) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (JJ postmenopausal) (NNS women))) (PP (IN than) (PP (IN in) (NP (JJ young) (NNS women))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS factors)) (CONJP (JJ other) (IN than)) (NP (NN body) (NN mass) (NN index))) (VP (MD may) (VP (VB be) (VP (VBN involved))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (PRP$ Our) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NNS differences)) (VP (VBZ is) (NP (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN galanin))) (PP (IN between) (NP (NP (JJ postmenopausal) (NNS women)) (CC and) (NP (JJ young) (NNS women))))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (PP (TO to) (NP (NN body) (NN mass) (NN index))) (CONJP (RB rather) (IN than)) (PP (TO to) (NP (NP (NNS differences)) (PP (IN in) (NP (JJ hormonal) (NN status))))))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (JJR higher) (NN _PROT2_) (NNS levels)) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (JJ postmenopausal) (NNS women))) (PP (IN than) (PP (IN in) (NP (JJ young) (NNS women))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS factors)) (CONJP (JJ other) (IN than)) (NP (NN body) (NN mass) (NN index))) (VP (MD may) (VP (VB be) (VP (VBN involved))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (PRP$ Our) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NNS differences)) (VP (VBZ is) (NP (NP (NP (NN plasma) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN galanin))) (PP (IN between) (NP (NP (JJ postmenopausal) (NNS women)) (CC and) (NP (JJ young) (NNS women))))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (PP (TO to) (NP (NN body) (NN mass) (NN index))) (CONJP (RB rather) (IN than)) (PP (TO to) (NP (NP (NNS differences)) (PP (IN in) (NP (JJ hormonal) (NN status))))))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (JJR higher) (NN _PROT2_) (NNS levels)) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (JJ postmenopausal) (NNS women))) (PP (IN than) (PP (IN in) (NP (JJ young) (NNS women))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS factors)) (CONJP (JJ other) (IN than)) (NP (NN body) (NN mass) (NN index))) (VP (MD may) (VP (VB be) (VP (VBN involved))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (S (ADVP (RB highly)) (VP (VBN expressed) (PP (IN in) (NP (JJ human) (NNS adipocytes))))) (, ,) (NP (DT the) (NN Y) (-LRB- -LRB-) (CD 1) (-RRB- -RRB-) (NN receptor)) (VP (VP (VBZ sustains) (NP (NP (DT the) (JJ strong) (JJ antilipolytic) (NN effect)) (PP (IN of) (NP (NN _PROT1_))))) (CC and) (VP (VBZ exerts) (NP (NP (DT a) (JJ positive) (NN action)) (PP (IN on) (NP (NN _PROT2_) (NN secretion)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN As) (S (VP (VBN expected) (, ,) (PP (IN in) (NP (NP (NN fusion)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (ADVP (RB alone))) (PRN (-LRB- -LRB-) (NP (CD 18) (NN microg/day)) (-RRB- -RRB-))))))))) (VP (VP (VBD augmented) (NP (NN food) (NN intake)) (PRN (-LRB- -LRB-) (NP (NP (CD 191.6) (NN %)) (PP (IN over) (NP (DT the) (JJ initial) (NN control)))) (, ,) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (VP (VBD produced) (NP (DT a) (ADJP (CD 25.1) (NN %)) (NN weight) (NN gain)) (PP (IN in) (NP (NP (NN conjunction)) (PP (IN with) (NP (NP (DT a) (JJ 10-fold) (NN increase)) (PP (IN in) (NP (NP (NN serum) (NN _PROT2_) (NNS concentrations)) (PP (IN at) (NP (NP (DT the) (NN end)) (PP (IN of) (NP (DT the) (JJ 7-day) (NN period))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (NP (NN coinfusion)) (PP (IN of) (NP (NP (DT this) (NN regimen)) (PP (IN of) (NP (NN _PROT1_))))) (PP (IN with) (NP (NP (DT the) (ADJP (RB highly) (JJ effective)) (ADJP (ADJP (JJ anorectic)) (CC and) (ADJP (NN body) (VBG reducing))) (NNS effects)) (PP (IN of) (NP (NN CNTF)))))) (PRN (-LRB- -LRB-) (NP (CD 5.0) (NN microg/day)) (-RRB- -RRB-)) (VP (CONJP (RB not) (RB only)) (VP (VBD prevented) (NP (NP (DT the) (JJ CNTF-induced) (NN anorexia)) (CC and) (NP (NN weight) (NN loss)))) (, ,) (CONJP (CC but) (RB also)) (VP (VBN normalized) (NP (NP (NN serum) (NN _PROT2_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT_) (NN gene) (NN expression))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (NP (NN coinfusion)) (PP (IN of) (NP (NP (DT this) (NN regimen)) (PP (IN of) (NP (NN _PROT1_))))) (PP (IN with) (NP (NP (DT the) (ADJP (RB highly) (JJ effective)) (ADJP (ADJP (JJ anorectic)) (CC and) (ADJP (NN body) (VBG reducing))) (NNS effects)) (PP (IN of) (NP (NN CNTF)))))) (PRN (-LRB- -LRB-) (NP (CD 5.0) (NN microg/day)) (-RRB- -RRB-)) (VP (CONJP (RB not) (RB only)) (VP (VBD prevented) (NP (NP (DT the) (JJ CNTF-induced) (NN anorexia)) (CC and) (NP (NN weight) (NN loss)))) (, ,) (CONJP (CC but) (RB also)) (VP (VBN normalized) (NP (NP (NN serum) (NN _PROT_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT2_) (NN gene) (NN expression))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (NP (NN coinfusion)) (PP (IN of) (NP (NP (DT this) (NN regimen)) (PP (IN of) (NP (NN _PROT_))))) (PP (IN with) (NP (NP (DT the) (ADJP (RB highly) (JJ effective)) (ADJP (ADJP (JJ anorectic)) (CC and) (ADJP (NN body) (VBG reducing))) (NNS effects)) (PP (IN of) (NP (NN CNTF)))))) (PRN (-LRB- -LRB-) (NP (CD 5.0) (NN microg/day)) (-RRB- -RRB-)) (VP (CONJP (RB not) (RB only)) (VP (VBD prevented) (NP (NP (DT the) (JJ CNTF-induced) (NN anorexia)) (CC and) (NP (NN weight) (NN loss)))) (, ,) (CONJP (CC but) (RB also)) (VP (VBN normalized) (NP (NP (NN serum) (NN _PROT1_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT2_) (NN gene) (NN expression))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ chronic) (JJ central) (NN infusion)) (VP (TO to) (VP (VB produce) (NP (NP (DT a) (JJ persistent) (NN elevation)) (PP (IN of) (NP (DT the) (NN cytokine)))) (PP (IN at) (NP (NP (JJ pathophysiological) (NNS levels)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN situation)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (ADVP (RB normally)) (VP (VBP manifest) (PP (IN during) (NP (NP (NN infection)) (, ,) (NP (NN injury)) (CC and) (NP (NN inflammation))))))))) (-RRB- -RRB-))))))) (VP (VBD produced) (NP (NP (NP (JJ severe) (NN anorexia)) (CC and) (NP (NN weight) (NN loss))) (PP (IN in) (NP (NP (NN conjunction)) (PP (IN with) (NP (NN reduction)))))) (PP (IN in) (NP (CC both) (NP (NN serum) (NN _PROT1_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT2_) (NN gene) (NN expression)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN ARC) (NN _PROT1_) (NNS neurones)) (VP (VP (VBP are) (VP (VBN stimulated) (PP (IN by) (NP (NP (NN starvation)) (, ,) (ADVP (RB probably)) (VP (VBN mediated) (PP (IN by) (NP (NP (NNS falls)) (PP (IN in) (S (VP (VBG circulating) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN insulin))) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (DT both) (VP (VBP inhibit) (NP (DT these) (NNS neurones)))))) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (VP (VBP contribute) (PP (TO to) (NP (NP (DT the) (VBN increased) (NN hunger)) (PP (IN in) (NP (NP (DT this)) (CC and) (NP (JJ other) (NNS conditions)))) (PP (IN of) (NP (NN energy) (NN deficit))))))))) |ET|
-1 |BT| (S1 (S (NP (NN ARC) (NN _PROT1_) (NNS neurones)) (ADVP (RB also)) (VP (VBP mediate) (NP (NP (NP (NN hyperphagia)) (CC and) (NP (NN obesity))) (PP (IN in) (NP (NP (DT the) (NP (NP (NN ob/ob)) (CC and) (NP (NN db/db))) (NNS mice)) (CC and) (NP (NN fa/fa) (NN rat)))) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_) (NN inhibition)) (VP (VBZ is) (VP (VBN lost) (PP (IN through) (NP (NP (NNS mutations)) (VP (VBG affecting) (NP (NP (NN _PROT_)) (CC or) (NP (PRP$ its) (NN receptor)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN ARC) (NN _PROT1_) (NNS neurones)) (ADVP (RB also)) (VP (VBP mediate) (NP (NP (NP (NN hyperphagia)) (CC and) (NP (NN obesity))) (PP (IN in) (NP (NP (DT the) (NP (NP (NN ob/ob)) (CC and) (NP (NN db/db))) (NNS mice)) (CC and) (NP (NN fa/fa) (NN rat)))) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_) (NN inhibition)) (VP (VBZ is) (VP (VBN lost) (PP (IN through) (NP (NP (NNS mutations)) (VP (VBG affecting) (NP (NP (NN _PROT2_)) (CC or) (NP (PRP$ its) (NN receptor)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN ARC) (NN _PROT_) (NNS neurones)) (ADVP (RB also)) (VP (VBP mediate) (NP (NP (NP (NN hyperphagia)) (CC and) (NP (NN obesity))) (PP (IN in) (NP (NP (DT the) (NP (NP (NN ob/ob)) (CC and) (NP (NN db/db))) (NNS mice)) (CC and) (NP (NN fa/fa) (NN rat)))) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_) (NN inhibition)) (VP (VBZ is) (VP (VBN lost) (PP (IN through) (NP (NP (NNS mutations)) (VP (VBG affecting) (NP (NP (NN _PROT2_)) (CC or) (NP (PRP$ its) (NN receptor)))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT Both)) (VP (VBP receive) (NP (NP (NN information)) (PP (IN about) (NP (NP (DT the) (JJ nutritional) (NN status)) (CC and) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN energy) (NN storage))))))) (PP (IN through) (NP (NP (NP (NP (NN insulin)) (CC and) (NP (NN _PROT1_))) (NN signaling)) (VP (VBN mediated) (PP (IN by) (NP (NP (JJ specific) (NNS receptors)) (ADJP (JJ located) (PP (IN on) (NP (NP (ADJP (ADJP (JJ POMC)) (CC and) (ADJP (JJ _PROT2_))) (NNS neurons)) (ADJP (JJ present) (PP (ADVP (RB predominantly)) (IN in) (NP (NP (DT the) (JJ arcuate) (NN nucleus)) (PRN (-LRB- -LRB-) (NP (NN ARC)) (-RRB- -RRB-))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (SBAR (WHADVP (WRB When)) (S (NP (NN _PROT1_) (NN signaling)) (VP (VBZ is) (ADJP (JJ defective)) (, ,) (PP (IN through) (NP (NP (DT a) (NN defect)) (PP (PP (IN in) (NP (DT either) (NP (NP (DT the) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NP (NN Zucker) (NN fa/fa) (NN rat)) (, ,) (NP (NN cp/cp) (NN rat)) (, ,) (CC and) (NP (NN db/db) (NN mouse))) (-RRB- -RRB-))))) (CC or) (PP (IN in) (NP (DT the) (NN peptide) (PRP itself))) (PRN (-LRB- -LRB-) (NP (NN ob/ob) (NN mouse)) (-RRB- -RRB-)))))))) (, ,) (NP (DT the) (NN _PROT2_) (NN system)) (VP (VBZ is) (VP (VBN upregulated) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN mRNA) (NN overexpression)) (CC and) (NP (VBN increased) (NN peptide) (NN release)))))))))) (, ,) (IN whereas) (S (NP (NP (DT the) (NN content)) (CC and/or) (NP (NP (NN release)) (PP (IN of) (NP (NP (DT some) (JJ inhibitory) (NNS peptides)) (PRN (-LRB- -LRB-) (NP (NN neurotensin)) (, ,) (NP (NN cholecystokinin)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN diminished))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (JJ specific) (NN OT) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN OTR)) (-RRB- -RRB-))) (PP (IN on) (NP (DT the) (NN endometrium) (S (VP (TO to) (VP (VB stimulate) (NP (JJ phosphoinositide) (-LRB- -LRB-) (NN PI) (-RRB- -RRB-) (NN hydrolysis))))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG activating) (NP (NP (NP (NP (DT the) (NN inositol) (NN trisphosphate)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN -diacylglycerol) (-LRB- -LRB-) (NN DAG) (-RRB- -RRB-) (NN second-messenger) (NN system)) (S (VP (TO to) (VP (VB promote) (NP (NN pulsatile) (NN PGF2) (NN alpha) (NN secretion)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Endometrial) (NN _PROT1_)) (VP (VP (VBD was) (VP (VBN increased) (PP (IN within) (NP (CD 30) (NNS seconds))) (PP (IN after) (NP (NN _PROT2_) (NN treatment))))) (CC and) (VP (VBD preceded) (NP (NP (DT the) (NN increase)) (PP (IN in) (NP (NP (NN PGF2) (NN alpha) (NN release)) (VP (VBN stimulated) (PP (IN by) (NP (NN _PROT_))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Endometrial) (NN _PROT1_)) (VP (VP (VBD was) (VP (VBN increased) (PP (IN within) (NP (CD 30) (NNS seconds))) (PP (IN after) (NP (NN _PROT_) (NN treatment))))) (CC and) (VP (VBD preceded) (NP (NP (DT the) (NN increase)) (PP (IN in) (NP (NP (NN PGF2) (NN alpha) (NN release)) (VP (VBN stimulated) (PP (IN by) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Endometrial) (NN _PROT_)) (VP (VP (VBD was) (VP (VBN increased) (PP (IN within) (NP (CD 30) (NNS seconds))) (PP (IN after) (NP (NN _PROT1_) (NN treatment))))) (CC and) (VP (VBD preceded) (NP (NP (DT the) (NN increase)) (PP (IN in) (NP (NP (NN PGF2) (NN alpha) (NN release)) (VP (VBN stimulated) (PP (IN by) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN phospholipase) (NN C)) (S (VP (TO to) (VP (VB hydrolyze) (NP (NN PI))))))))) (, ,) (S (VP (VBG yielding) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN DAG))) (NNS second-messengers)) (SBAR (WHNP (WDT which)) (S (VP (VBP promote) (NP (NP (JJ endometrial) (NN PGF2) (NN alpha)) (NN release)) (PP (IN during) (NP (NP (NN CL) (NN regression)) (PP (IN in) (NP (NNS pigs)))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT1_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT2_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT1_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT_) (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT1_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT2_) (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT1_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT_) (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT1_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT2_) (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT2_) (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (MD may) (ADVP (RB rapidly)) (VP (VB stimulate) (NP (NP (ADJP (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (JJ _PROT2_) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-)))) (CC and) (NP (NP (NN diacylglycerol)) (PRN (-LRB- -LRB-) (NP (NN DAG)) (-RRB- -RRB-))) (NP (NN formation))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (NN concept)) (PP (IN of) (NP (NP (JJ rapid) (NN activation)) (PP (IN of) (NP (DT a) (NN second-messenger) (NN system))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (NN support)) (PP (IN of) (NP (DT this) (NN hypothesis))))) (, ,) (NP (JJ endometrial) (NN _PROT1_) (NNS levels)) (VP (VBD were) (VP (VBN increased) (PRN (-LRB- -LRB-) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN within) (NP (CD 0.5) (NN min))) (PP (IN after) (NP (NP (NN treatment)) (PP (IN with) (NP (ADJP (CD 0.1) (NN microM)) (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (JJ endometrial) (NN _PROT2_) (NN production)) (PP (IN in) (NP (NP (DT a) (JJ rapid) (NN manner)) (ADJP (JJ indicative) (PP (IN of) (NP (DT a) (NN second-messenger) (NN system)))))))))))) |ET|
-1 |BT| (S1 (S (S (LST (LS 2) (-RRB- -RRB-)) (NP (NP (NN IGF-1)) (, ,) (NP (NN IGF-2)) (, ,) (CC and) (NP (NN _PROT1_))) (ADVP (RB also)) (VP (VBD induced) (NP (NP (DT a) (NN Ca2+) (NN mobilization)) (PP (IN from) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))) (: :) (S (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NNS inhibitors)) (, ,) (NP (NN neomycin)) (, ,) (CC or) (NP (NN U-73122))) (VP (VP (ADVP (RB partially)) (VBD blocked) (NP (NP (DT the) (JJ intracellular) (NN [Ca2+) (-RRB- -RSB-) (NN i) (NN increase)) (VP (VBN induced) (PP (IN by) (NP (NP (NN IGF-1)) (CC and) (NP (NN _PROT_))))))) (CC and) (VP (ADVP (RB totally)) (VBD inhibited) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN IGF-2))))))))) |ET|
-1 |BT| (S1 (S (S (LST (LS 2) (-RRB- -RRB-)) (NP (NP (NN IGF-1)) (, ,) (NP (NN IGF-2)) (, ,) (CC and) (NP (NN _PROT1_))) (ADVP (RB also)) (VP (VBD induced) (NP (NP (DT a) (NN Ca2+) (NN mobilization)) (PP (IN from) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))) (: :) (S (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NNS inhibitors)) (, ,) (NP (NN neomycin)) (, ,) (CC or) (NP (NN U-73122))) (VP (VP (ADVP (RB partially)) (VBD blocked) (NP (NP (DT the) (JJ intracellular) (NN [Ca2+) (-RRB- -RSB-) (NN i) (NN increase)) (VP (VBN induced) (PP (IN by) (NP (NP (NN IGF-1)) (CC and) (NP (NN _PROT2_))))))) (CC and) (VP (ADVP (RB totally)) (VBD inhibited) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN IGF-2))))))))) |ET|
+1 |BT| (S1 (S (S (LST (LS 2) (-RRB- -RRB-)) (NP (NP (NN IGF-1)) (, ,) (NP (NN IGF-2)) (, ,) (CC and) (NP (NN _PROT_))) (ADVP (RB also)) (VP (VBD induced) (NP (NP (DT a) (NN Ca2+) (NN mobilization)) (PP (IN from) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))) (: :) (S (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NNS inhibitors)) (, ,) (NP (NN neomycin)) (, ,) (CC or) (NP (NN U-73122))) (VP (VP (ADVP (RB partially)) (VBD blocked) (NP (NP (DT the) (JJ intracellular) (NN [Ca2+) (-RRB- -RSB-) (NN i) (NN increase)) (VP (VBN induced) (PP (IN by) (NP (NP (NN IGF-1)) (CC and) (NP (NN _PROT2_))))))) (CC and) (VP (ADVP (RB totally)) (VBD inhibited) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN IGF-2))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN expression)) (CC and) (NP (NN energy) (NN expenditure)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA) (NNS levels)) (NP (JJR greater) (IN than) (RB twofold)) (PP (IN in) (NP (DT both) (NN ad) (JJ libitum-fed) (CC and) (JJ food-restricted) (NNS rats)))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (NP (NP (DT a) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN energy) (NN expenditure))) (PP (IN in) (NP (JJ nonmutant) (NNS rodents))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ increases) (NP (NN energy) (NN expenditure)))))) (VP (VBZ is) (PP (IN through) (NP (NP (VBN increased) (NN thermogenesis)) (PP (IN in) (NP (NN BAT))))) (, ,) (S (VP (VBG including) (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (NN _PROT_))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (NP (NP (DT a) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN energy) (NN expenditure))) (PP (IN in) (NP (JJ nonmutant) (NNS rodents))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NN energy) (NN expenditure)))))) (VP (VBZ is) (PP (IN through) (NP (NP (VBN increased) (NN thermogenesis)) (PP (IN in) (NP (NN BAT))))) (, ,) (S (VP (VBG including) (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (NP (NP (DT a) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN energy) (NN expenditure))) (PP (IN in) (NP (JJ nonmutant) (NNS rodents))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NN energy) (NN expenditure)))))) (VP (VBZ is) (PP (IN through) (NP (NP (VBN increased) (NN thermogenesis)) (PP (IN in) (NP (NN BAT))))) (, ,) (S (VP (VBG including) (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NP (NNS thermogenesis)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN thyroid) (NN hormone)) (, ,) (NP (JJ beta3-adrenergic) (NNS agonists)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN mRNA) (NNS levels)) (VP (VBD were) (ADVP (RB also)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN dexamethasone)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN starvation))))) (, ,) (SBAR (IN albeit) (FRAG (RB differently) (PP (IN in) (NP (NP (NN muscle)) (CC and) (NP (JJ brown) (NN adipose) (NN tissue))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN PKB)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (DT an) (JJ important) (JJ early) (NN PI) (NN 3-kinase-dependent) (NN component)) (PP (IN of) (NP (NN _PROT1_) (NN signalling) (NNS pathways))))))) (, ,)) (VP (VBZ is) (ADVP (RB also)) (VP (VBN down-regulated) (PP (IN by) (NP (JJ _PROT2_) (NNS agonists))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Secreted) (NN form)) (PP (IN of) (NP (NN _PROT1_) (NN precursor) (NN protein)))) (VP (VBZ activates) (NP (NP (NP (NN protein) (NN kinase) (NN C)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (VBN cultured) (JJ embryonic) (NN rat) (JJ neocortical) (NNS cells))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (NP (NP (NN formation)) (PP (IN of) (NP (NN inositol) (NN 1,4,5-trisphosphate))))) (VP (VBD were) (VP (VBN increased) (PP (IN by) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (JJ possible) (NN involvement)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (NN IL-1) (NN action)))) (PP (IN in) (NP (NN Leydig) (NNS cells))))))) (, ,) (NP (DT the) (NN _PROT_) (NN inhibitor) (NN Calphostin) (NN C)) (VP (VBD was) (VP (VBN tested))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (JJ possible) (NN involvement)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (NN IL-1) (NN action)))) (PP (IN in) (NP (NN Leydig) (NNS cells))))))) (, ,) (NP (DT the) (NN _PROT2_) (NN inhibitor) (NN Calphostin) (NN C)) (VP (VBD was) (VP (VBN tested))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (JJ possible) (NN involvement)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (NN IL-1) (NN action)))) (PP (IN in) (NP (NN Leydig) (NNS cells))))))) (, ,) (NP (DT the) (NN _PROT2_) (NN inhibitor) (NN Calphostin) (NN C)) (VP (VBD was) (VP (VBN tested))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN PMA))) (VP (VBP activate) (NP (NN _PROT2_)))))) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN IL-1)) (ADVP (RB likely)) (VP (VBZ does) (RB not) (VP (VB activate) (NP (NN _PROT_)) (PP (IN in) (NP (NN Leydig) (NNS cells))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN PMA))) (VP (VBP activate) (NP (NN _PROT_)))))) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN IL-1)) (ADVP (RB likely)) (VP (VBZ does) (RB not) (VP (VB activate) (NP (NN _PROT2_)) (PP (IN in) (NP (NN Leydig) (NNS cells))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN PMA))) (VP (VBP activate) (NP (NN _PROT1_)))))) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN IL-1)) (ADVP (RB likely)) (VP (VBZ does) (RB not) (VP (VB activate) (NP (NN _PROT2_)) (PP (IN in) (NP (NN Leydig) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN If) (S (NP (JJ daily) (NN _PROT1_) (NNS injections)) (VP (VBP are) (VP (VBN repeated) (PP (IN over) (NP (DT a) (JJ 5-day) (NN period))))))) (, ,) (S (S (NP (NN blood) (NN pressure)) (VP (VBZ is) (VP (VBN decreased) (PP (IN by) (NP (CD 10-20) (NN mmHg)))))) (, ,) (S (NP (NP (DT the) (NN withdrawal) (NN latency)) (PP (TO to) (NP (NN heat) (NNS stimuli)))) (VP (VBZ is) (ADJP (JJ prolonged)))) (, ,) (S (NP (NN cortisol) (NNS levels)) (VP (VBP are) (VP (VBN decreased)))) (CC and) (S (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN cholecystokinin))) (NNS levels)) (VP (VBP are) (VP (VBN increased))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (CC and) (NP (NN _PROT1_))) (VP (VBP modulate) (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN _PROT2_))))) (: :) (NP (NP (JJ divergent) (NNS effects)) (PP (IN between) (NP (NP (NN messenger) (JJ ribonucleic) (NN acid)) (CC and) (NP (NN protein) (NN expression))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN fasting)) (PP (IN for) (NP (CD 2) (NNS days)))) (CC and) (NP (NP (JJ exogenous) (NN s.c.) (NN _PROT1_)) (, ,) (NP (NP (ADJP (CD 200) (NN microg)) (DT every) (CD 8) (NN h)) (PP (IN for) (NP (CD 2) (NNS days)))) (, ,)))) (PP (IN on) (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP)) (-RRB- -RRB-))) (NNS subtypes)))))) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ gastrocnemius) (NN muscle))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (, ,) (PP (VBN compared) (PP (IN with) (NP (NN vehicle)))) (, ,) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN BAT) (NN _PROT2_)) (CC or) (NP (NN _PROT_) (NN mRNA)) (CC or) (NP (NN protein) (NN expression)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN administered) (PP (TO to) (NP (JJ normal) (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (, ,) (PP (VBN compared) (PP (IN with) (NP (NN vehicle)))) (, ,) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN BAT) (NN _PROT_)) (CC or) (NP (NN _PROT2_) (NN mRNA)) (CC or) (NP (NN protein) (NN expression)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN administered) (PP (TO to) (NP (JJ normal) (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (, ,) (PP (VBN compared) (PP (IN with) (NP (NN vehicle)))) (, ,) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN BAT) (NN _PROT1_)) (CC or) (NP (NN _PROT2_) (NN mRNA)) (CC or) (NP (NN protein) (NN expression)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN administered) (PP (TO to) (NP (JJ normal) (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NN BAT) (NN _PROT1_) (CC and) (NN _PROT2_) (NN mRNA) (NN expression)) (, ,) (PP (TO to) (NP (NP (NP (CD 31) (NN %)) (CC and) (NP (CD 30) (NN %))) (PP (IN of) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))) (, ,) (ADVP (RB respectively)) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (VP (VBN prevented) (PP (IN by) (NP (NP (NN administration)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (JJ fasted) (NNS rats))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NN BAT) (NN _PROT1_) (CC and) (NN _PROT_) (NN mRNA) (NN expression)) (, ,) (PP (TO to) (NP (NP (NP (CD 31) (NN %)) (CC and) (NP (CD 30) (NN %))) (PP (IN of) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))) (, ,) (ADVP (RB respectively)) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (VP (VBN prevented) (PP (IN by) (NP (NP (NN administration)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (JJ fasted) (NNS rats))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NN BAT) (NN _PROT_) (CC and) (NN _PROT1_) (NN mRNA) (NN expression)) (, ,) (PP (TO to) (NP (NP (NP (CD 31) (NN %)) (CC and) (NP (CD 30) (NN %))) (PP (IN of) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))) (, ,) (ADVP (RB respectively)) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (VP (VBN prevented) (PP (IN by) (NP (NP (NN administration)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (JJ fasted) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Fasting)) (ADVP (RB also)) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NN BAT) (NN _PROT1_) (NN protein) (NN expression)) (, ,) (PP (TO to) (NP (NP (CD 67) (NN %)) (PP (IN of) (NP (NN control))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (DT that) (NN effect)) (VP (VBD was) (RB not) (VP (VBN prevented) (PP (IN by) (NP (NN _PROT2_) (NN treatment)))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT1_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT2_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT1_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT2_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT1_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT1_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT2_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT1_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT1_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD enhanced) (NP (NP (NP (JJ gastrocnemius) (NN muscle) (NN _PROT1_) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (NP (CD 411) (NN %)) (PP (IN of) (NP (NN control)))) (-RRB- -RRB-))) (CC and) (NP (NP (NN protein) (NN expression)) (PRN (-LRB- -LRB-) (NP (NP (CD 168) (NN %)) (PP (IN of) (NP (NN control)))) (-RRB- -RRB-)))) (, ,) (SBAR (IN whereas) (S (NP (NP (JJ _PROT2_) (NN administration)) (PP (TO to) (NP (JJ fasted) (NNS rats)))) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (DT either)) (PP (IN of) (NP (DT these) (NNS effects))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (NP (NN _PROT1_) (NN subtype) (NN mRNA)) (CC and) (NP (NN protein))) (VP (VBP are) (VP (VBN regulated) (PP (IN in) (NP (NP (NN tissue-)) (CC and) (NP (NN subtype-specific)) (NP (NN fashion)))) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN food) (NN restriction)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ normal) (JJ pancreatic) (NNS islets))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT2_))))) (CC and) (VP (VBZ is) (ADJP (JJ low) (PP (IN in) (NP (NP (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (NN ZDF) (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ normal) (JJ pancreatic) (NNS islets))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT_))))) (CC and) (VP (VBZ is) (ADJP (JJ low) (PP (IN in) (NP (NP (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (NN ZDF) (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ normal) (JJ pancreatic) (NNS islets))) (, ,) (NP (NN _PROT_)) (VP (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT1_))))) (CC and) (VP (VBZ is) (ADJP (JJ low) (PP (IN in) (NP (NP (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (NN ZDF) (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT2_) (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT_) (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT_) (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT2_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT1_) (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT1_) (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT2_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT_) (JJ _PROT1_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT2_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP conclude) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NN uncoupling) (NN function)) (SBAR (WHADVP (WRB when)) (S (VP (VBN overexpressed) (PP (IN in) (NP (JJ _PROT2_) (NNS islets))))))))) (CC and) (SBAR (IN that) (S (NP (PRP$ its) (NN overexpression)) (VP (VP (VBZ corrects) (NP (NP (DT the) (NN underexpression)) (PP (IN of) (NP (DT the) (NN insulin) (NN gene))))) (CC and) (VP (VBZ ameliorates) (NP (JJ glucose-stimulated) (NN insulin) (NN secretion))) (, ,) (PP (ADVP (RB possibly)) (IN by) (S (VP (VBG increasing) (NP (DT the) (NN ATP) (: :) (NN ADP) (NN ratio)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT2_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT2_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT2_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT1_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT2_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT1_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT2_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT1_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT2_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS Neurotransmitters)) (CC and) (NP (NNS hormones))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (NN arginine) (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NN bombesin)))) (, ,)) (VP (VB evoke) (NP (NP (JJ frequency-modulated) (JJ repetitive) (NN Ca2+) (NNS transients)) (PP (IN in) (NP (JJ _PROT1_) (NN HIT-T15) (NNS cells)))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (NNS receptors)) (VP (VBN linked) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ _PROT1_) (NN signaling)) (PP (IN in) (NP (NN yeast)))) (: :) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NP (NN protein) (NN phosphatase) (NN 2A)) (, ,) (NP (NN protein) (NN kinase) (NN A)) (, ,) (NP (JJ cAMP-specific) (NN phosphodiesterase)) (, ,) (CC and) (NP (JJ glycosyl-phosphatidylinositol-specific) (NN _PROT2_) (NN _PROT2_))) (NNS activities))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT1_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT1_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RBS most) (RB pronouncedly)) (VP (VBN stimulated) (PP (IN by) (NP (JJ authentic) (JJ human) (NN _PROT2_))) (PP (VBN compared) (PP (TO to) (NP (NP (JJ various) (NN insulin) (NNS analogues)) (CC and) (NP (JJ insulin-like) (NN growth) (NN factor) (CD I))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN As) (S (NP (DT the) (NN _PROT1_) (NN reaction)) (VP (VBZ is) (ADJP (NN rate) (VBG limiting))))) (, ,) (NP (NP (DT the) (NN efficiency)) (PP (IN of) (NP (DT the) (JJ two-step) (NN anchor) (NN cleavage)))) (VP (VBD was) (ADVP (RB significantly)) (VP (VBN increased)) (SBAR (WHADVP (WRB when)) (S (NP (NN _PROT2_)) (VP (VBD was) (ADJP (JJ present)) (PP (ADVP (RB together)) (IN with) (NP (NN glucose))) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN glucose))) (ADVP (RB alone))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NNS concentrations)) (ADJP (JJ effective) (PP (IN in) (S (VP (VBG modulating) (NP (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS activities))))))) (VP (VBP correlate) (ADVP (RB well)) (PP (IN with) (NP (NP (DT those)) (VP (VBN required) (PP (PP (IN for) (NP (NP (NN half-saturation)) (PP (IN of) (NP (DT the) (JJ specific) (NN binding) (NNS sites))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN protein) (NN phosphorylation)) (CC and) (NP (NN glycogen) (NN accumulation))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ mammalian) (JJ _PROT1_) (NNS cells)) (CC and) (NP (NN yeast))) (VP (VBP share) (PRN (-LRB- -LRB-) (NP (NP (NN part)) (PP (IN of))) (-RRB- -RRB-)) (NP (NP (DT the) (JJ key) (JJ regulatory) (NN mechanism)) (-LRB- -LRB-) (VP (VBG consisting) (PP (IN of) (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT2_))))) (-RRB- -RRB-) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN transduction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN signal)) (PP (IN from) (NP (DT the) (JJ respective) (NN receptor) (NNS systems))) (PP (TO to) (NP (NP (NN glycogen) (NN synthase)) (CC and) (NP (NN phosphorylase)))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ mammalian) (JJ _PROT1_) (NNS cells)) (CC and) (NP (NN yeast))) (VP (VBP share) (PRN (-LRB- -LRB-) (NP (NP (NN part)) (PP (IN of))) (-RRB- -RRB-)) (NP (NP (DT the) (JJ key) (JJ regulatory) (NN mechanism)) (-LRB- -LRB-) (VP (VBG consisting) (PP (IN of) (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT_))))) (-RRB- -RRB-) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN transduction)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN signal)) (PP (IN from) (NP (DT the) (JJ respective) (NN receptor) (NNS systems))) (PP (TO to) (NP (NP (NN glycogen) (NN synthase)) (CC and) (NP (NN phosphorylase)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ mammalian) (JJ _PROT_) (NNS cells)) (CC and) (NP (NN yeast))) (VP (VBP share) (PRN (-LRB- -LRB-) (NP (NP (NN part)) (PP (IN of))) (-RRB- -RRB-)) (NP (NP (DT the) (JJ key) (JJ regulatory) (NN mechanism)) (-LRB- -LRB-) (VP (VBG consisting) (PP (IN of) (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT1_))))) (-RRB- -RRB-) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN transduction)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN signal)) (PP (IN from) (NP (DT the) (JJ respective) (NN receptor) (NNS systems))) (PP (TO to) (NP (NP (NN glycogen) (NN synthase)) (CC and) (NP (NN phosphorylase)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (ADJP (NN glycosyl-phosphatidylinositol) (VBN anchored)) (NN protein)) (, ,) (NP (NP (NN membrane) (NN dipeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.13.19)) (-RRB- -RRB-)))) (VP (VBZ is) (VP (VBN released) (PP (IN from) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN 3T3-L1) (NNS adipocytes))))) (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_) (NN treatment))) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN X-Pro) (NN aminopeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.11.9)) (-RRB- -RRB-))) (VP (VBZ is) (ADJP (JJ GPI-anchored)) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes))) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN digestion)) (PP (IN with) (NP (JJ bacterial) (JJ phosphatidylinositol-specific) (NN _PROT1_) (NN _PROT1_))))))))))) (, ,) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN released) (PP (IN upon) (NP (NP (NN _PROT2_) (NN treatment)) (PP (IN of) (NP (DT the) (NNS cells)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (RB only) (DT a) (NN subset)) (PP (IN of) (NP (DT the) (JJ GPI-anchored) (NNS proteins)))) (VP (VBP are) (ADJP (JJ susceptible) (PP (TO to) (NP (JJ _PROT_) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN X-Pro) (NN aminopeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.11.9)) (-RRB- -RRB-))) (VP (VBZ is) (ADJP (JJ GPI-anchored)) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes))) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN digestion)) (PP (IN with) (NP (JJ bacterial) (JJ phosphatidylinositol-specific) (NN _PROT1_) (NN _PROT1_))))))))))) (, ,) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN released) (PP (IN upon) (NP (NP (NN _PROT_) (NN treatment)) (PP (IN of) (NP (DT the) (NNS cells)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (RB only) (DT a) (NN subset)) (PP (IN of) (NP (DT the) (JJ GPI-anchored) (NNS proteins)))) (VP (VBP are) (ADJP (JJ susceptible) (PP (TO to) (NP (JJ _PROT2_) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN X-Pro) (NN aminopeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.11.9)) (-RRB- -RRB-))) (VP (VBZ is) (ADJP (JJ GPI-anchored)) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes))) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN digestion)) (PP (IN with) (NP (JJ bacterial) (JJ phosphatidylinositol-specific) (NN _PROT_) (NN _PROT_))))))))))) (, ,) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN released) (PP (IN upon) (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (DT the) (NNS cells)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (RB only) (DT a) (NN subset)) (PP (IN of) (NP (DT the) (JJ GPI-anchored) (NNS proteins)))) (VP (VBP are) (ADJP (JJ susceptible) (PP (TO to) (NP (JJ _PROT2_) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN established) (SBAR (IN that) (S (NP (NP (DT the) (NN recovery)) (PP (IN of) (NP (VBN secreted) (NN _PROT1_)))) (VP (VBZ is) (VP (VBN increased) (PP (IN by) (NP (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NNS agonists)) (NP (NP (NN PDBu)) (CC and) (NP (NN PMA))))) (PP (IN in) (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN manner))) (PP (IN in) (NP (DT both) (NN cell) (NNS lines))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN secretion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ remains) (VP (VBN unaffected) (PP (PP (IN by) (NP (DT the) (JJ inactive) (NN PDBu) (NN analog) (NN alphaPDD))) (CC and) (PP (IN by) (NP (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NNS effectors)) (NP (NP (NN dibutyryl) (NN cAMP)) (CC and) (NP (NN forskolin)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ normal) (NN processing)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))) (VP (VBZ is) (VP (VBN up-regulated) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (PP (IN in) (NP (NP (JJ human) (NNS cells)) (CC and) (NP (JJ murine) (NNS neurons))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ normal) (NN processing)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))) (VP (VBZ is) (VP (VBN up-regulated) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NP (JJ human) (NNS cells)) (CC and) (NP (JJ murine) (NNS neurons))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ normal) (NN processing)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))) (VP (VBZ is) (VP (VBN up-regulated) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NP (JJ human) (NNS cells)) (CC and) (NP (JJ murine) (NNS neurons))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ caveolin-1-dependent) (NN coupling)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (VP (VBD was) (VP (VBN observed))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Recently)) (NP (JJ several) (JJ significant) (NNS advances)) (VP (VBP have) (VP (VBN been) (VP (VBN made) (PP (IN in) (NP (DT this) (NN area))) (, ,) (PP (VBG including) (NP (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ appetite) (NN regulating) (NN hormone)) (, ,) (NP (NN _PROT1_)) (, ,)))) (CC and) (NP (NP (DT a) (JJ detailed) (NN understanding)) (PP (IN of) (NP (NP (PRP$ its) (NNS targets)) (PP (IN in) (NP (NP (DT the) (JJ central) (JJ nervous) (NN system)) (PRN (-LRB- -LRB-) (NP (NN CNS)) (-RRB- -RRB-)))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NN melanocortin-4) (NN receptor)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Activity)) (CC and) (NP (NN expression))) (PP (IN of) (NP (DT the) (CD three) (NN _PROT1_) (NNS 's)))) (VP (VBP are) (VP (VBN stimulated) (PP (IN by) (NP (NP (NP (JJ several) (NNS neuromediators)) (CC and) (NP (NNS hormones))) (PP (JJ such) (IN as) (NP (NP (NN noradrenaline)) (, ,) (NP (NN tri-iodothyronine)) (CC and) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN _PROT2_) (NN level))) (PP (IN in) (NP (VBG outgrowing) (NNS spores)))) (VP (VBZ depends) (ADVP (RB mainly)) (PP (IN on) (NP (NN _PROT1_))) (, ,) (SBAR (IN because) (S (NP (NN sigB) (NNS mutants)) (VP (VBP show) (NP (NP (JJ normal) (NN KatX) (NN activity)) (PP (IN in) (NP (ADJP (ADJP (JJ dormant)) (CC and) (ADJP (JJ outgrowing))) (NNS spores)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (NP (DT the) (JJ physiological) (NN role)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT2_) (NN expression)))) (VP (VBZ remains) (ADJP (JJ obscure)))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (QP (CD -10) (CC and) (CD -35)) (NNS sequences)) (PP (IN of) (NP (NP (DT the) (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT2_))) (NNS promoters)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBP overlap))) (, ,) (CC and) (S (NP (NP (DT the) (JJ transcriptional) (NN start) (NNS points)) (VP (VBN used) (PP (IN by) (NP (NP (NN EsigmaB)) (CC and) (NP (NN EsigmaF)))))) (VP (VBP differ) (PP (IN by) (NP (QP (RB only) (CD one)) (NN nucleotide)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (QP (CD -10) (CC and) (CD -35)) (NNS sequences)) (PP (IN of) (NP (NP (DT the) (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT_))) (NNS promoters)) (PP (IN of) (NP (NN _PROT2_)))))) (VP (VBP overlap))) (, ,) (CC and) (S (NP (NP (DT the) (JJ transcriptional) (NN start) (NNS points)) (VP (VBN used) (PP (IN by) (NP (NP (NN EsigmaB)) (CC and) (NP (NN EsigmaF)))))) (VP (VBP differ) (PP (IN by) (NP (QP (RB only) (CD one)) (NN nucleotide)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (QP (CD -10) (CC and) (CD -35)) (NNS sequences)) (PP (IN of) (NP (NP (DT the) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ _PROT1_))) (NNS promoters)) (PP (IN of) (NP (NN _PROT2_)))))) (VP (VBP overlap))) (, ,) (CC and) (S (NP (NP (DT the) (JJ transcriptional) (NN start) (NNS points)) (VP (VBN used) (PP (IN by) (NP (NP (NN EsigmaB)) (CC and) (NP (NN EsigmaF)))))) (VP (VBP differ) (PP (IN by) (NP (QP (RB only) (CD one)) (NN nucleotide)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB also)) (NP (DT a) (JJ _PROT1_) (JJ general) (NN stress) (NN gene)) (, ,) (SBAR (IN since) (S (NP (PRP it)) (VP (VBZ is) (ADVP (RB strongly)) (VP (VBN induced) (PP (PP (IN by) (NP (NP (NN heat)) (, ,) (NP (NN salt)) (CC and) (NP (NN ethanol) (NN stress)))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NN energy) (NN depletion))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN gene)) (PP (IN of) (NP (FW Bacillus) (FW subtilis))) (, ,) (VP (VBG encoding) (NP (DT a) (JJ catabolic) (NN glutamate) (NN dehydrogenase))) (, ,)) (VP (VP (VBZ is) (VP (VBN transcribed) (PP (IN by) (NP (JJ _PROT1_) (NN RNA) (NN polymerase))))) (CC and) (VP (VBZ requires) (PP (IN for) (NP (NP (PRP$ its) (NN expression) (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN NtrC/NifA) (NN family)) (PP (IN of) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP bind) (PP (TO to) (NP (NP (JJ enhancer-like) (NNS elements)) (, ,) (VP (VBN called) (S (NP (NP (JJ upstream) (NN activating) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NNS UAS)) (-RRB- -RRB-)))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT2_) (NN gene)) (PP (IN of) (NP (FW Bacillus) (FW subtilis))) (, ,) (VP (VBG encoding) (NP (DT a) (JJ catabolic) (NN glutamate) (NN dehydrogenase))) (, ,)) (VP (VP (VBZ is) (VP (VBN transcribed) (PP (IN by) (NP (JJ _PROT1_) (NN RNA) (NN polymerase))))) (CC and) (VP (VBZ requires) (PP (IN for) (NP (NP (PRP$ its) (NN expression) (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN NtrC/NifA) (NN family)) (PP (IN of) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP bind) (PP (TO to) (NP (NP (JJ enhancer-like) (NNS elements)) (, ,) (VP (VBN called) (S (NP (NP (JJ upstream) (NN activating) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NNS UAS)) (-RRB- -RRB-)))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT2_) (NN gene)) (PP (IN of) (NP (FW Bacillus) (FW subtilis))) (, ,) (VP (VBG encoding) (NP (DT a) (JJ catabolic) (NN glutamate) (NN dehydrogenase))) (, ,)) (VP (VP (VBZ is) (VP (VBN transcribed) (PP (IN by) (NP (JJ _PROT_) (NN RNA) (NN polymerase))))) (CC and) (VP (VBZ requires) (PP (IN for) (NP (NP (PRP$ its) (NN expression) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT the) (NN NtrC/NifA) (NN family)) (PP (IN of) (NP (NP (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VBP bind) (PP (TO to) (NP (NP (JJ enhancer-like) (NNS elements)) (, ,) (VP (VBN called) (S (NP (NP (JJ upstream) (NN activating) (NNS sequences)) (PRN (-LRB- -LRB-) (NP (NNS UAS)) (-RRB- -RRB-)))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (DT the) (NN case)) (PP (IN for) (NP (JJ other) (ADJP (NN _PROT1_) (-LRB- _PROT1_) (CD _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NNS genes))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ has) (NP (DT no) (NNS UAS)))) (: ;) (S (ADVP (RB instead)) (, ,) (NP (PRP$ its) (NN expression)) (VP (VBZ depends) (PP (IN on) (NP (NP (DT a) (NN sequence)) (ADJP (JJ located) (ADVP (NP (CD 1.5) (NNS kilobases)) (RB downstream) (PP (IN of) (NP (DT the) (NN rocG) (NN promoter))))))) (, ,) (PP (IN beyond) (NP (NP (DT the) (NN end)) (PP (IN of) (NP (DT the) (NN rocG) (NN coding) (NN region))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NN addition) (TO to) (S (VP (VBG controlling) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ appears) (S (VP (TO to) (VP (VB control) (NP (NP (NN expression)) (PP (IN of) (NP (NP (QP (IN at) (JJS least) (CD one)) (JJ other) (NN gene)) (VP (VBN required) (PP (IN for) (NP (NP (NN production)) (PP (IN of) (NP (NN CSF)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (ADJP (JJ overproduced)) (CC and) (VP (VP (VBN purified) (NP (NP (NN sigma)) (PRN (-LRB- -LRB-) (NP (NN X)) (-RRB- -RRB-))) (PP (IN from) (NP (FW Escherichia) (FW coli)))) (CC and) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (ADVP (FW in) (FW vitro)) (, ,) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)))) (NNS holoenzymes)) (VP (VBP recognize) (NP (NP (NN promoter) (NNS elements)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (ADJP (JJ overproduced)) (CC and) (VP (VP (VBN purified) (NP (NP (NN sigma)) (PRN (-LRB- -LRB-) (NP (NN X)) (-RRB- -RRB-))) (PP (IN from) (NP (FW Escherichia) (FW coli)))) (CC and) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (ADVP (FW in) (FW vitro)) (, ,) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)))) (NNS holoenzymes)) (VP (VBP recognize) (NP (NP (NN promoter) (NNS elements)) (PP (IN within) (NP (DT the) (NN _PROT2_) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (ADJP (JJ overproduced)) (CC and) (VP (VP (VBN purified) (NP (NP (NN sigma)) (PRN (-LRB- -LRB-) (NP (NN X)) (-RRB- -RRB-))) (PP (IN from) (NP (FW Escherichia) (FW coli)))) (CC and) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (ADVP (FW in) (FW vitro)) (, ,) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)))) (NNS holoenzymes)) (VP (VBP recognize) (NP (NP (NN promoter) (NNS elements)) (PP (IN within) (NP (DT the) (NN _PROT2_) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (ADJP (JJ overproduced)) (CC and) (VP (VP (VBN purified) (NP (NP (NN sigma)) (PRN (-LRB- -LRB-) (NP (NN X)) (-RRB- -RRB-))) (PP (IN from) (NP (FW Escherichia) (FW coli)))) (CC and) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (ADVP (FW in) (FW vitro)) (, ,) (NP (CC both) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))) (NNS holoenzymes)) (VP (VBP recognize) (NP (NP (NN promoter) (NNS elements)) (PP (IN within) (NP (DT the) (NN _PROT2_) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (ADJP (JJ overproduced)) (CC and) (VP (VP (VBN purified) (NP (NP (NN sigma)) (PRN (-LRB- -LRB-) (NP (NN X)) (-RRB- -RRB-))) (PP (IN from) (NP (FW Escherichia) (FW coli)))) (CC and) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (ADVP (FW in) (FW vitro)) (, ,) (NP (CC both) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))) (NNS holoenzymes)) (VP (VBP recognize) (NP (NP (NN promoter) (NNS elements)) (PP (IN within) (NP (DT the) (NN _PROT2_) (NN control) (NN region)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (ADJP (JJ overproduced)) (CC and) (VP (VP (VBN purified) (NP (NP (NN sigma)) (PRN (-LRB- -LRB-) (NP (NN X)) (-RRB- -RRB-))) (PP (IN from) (NP (FW Escherichia) (FW coli)))) (CC and) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (ADVP (FW in) (FW vitro)) (, ,) (NP (CC both) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)))) (NNS holoenzymes)) (VP (VBP recognize) (NP (NP (NN promoter) (NNS elements)) (PP (IN within) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT that) (NN respect))) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN gene) (NN _PROT2_)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN regulon)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT that) (NN respect))) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN gene) (NN _PROT_)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN regulon)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT that) (NN respect))) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (ADJP (RB previously) (VBN described)) (NN gene) (NN _PROT1_)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN regulon)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Northern) (NN blot)) (CC and) (NP (NN primer) (NN extension)) (NP (NNS analyses))) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN transcribed) (PP (IN by) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (IN during) (NP (NN sporulation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN regulator)) (PP (IN for) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ contributes) (PP (TO to) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ putative) (JJ membrane-bound) (NN glucosyl) (NN transferase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADVP (RB partially)) (VP (VBN controlled) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN stress) (NN response) (NN sigma) (NN factor)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ contributes) (PP (TO to) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ putative) (JJ membrane-bound) (NN glucosyl) (NN transferase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADVP (RB partially)) (VP (VBN controlled) (PP (IN by) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN stress) (NN response) (NN sigma) (NN factor)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_) (NN _PROT_)) (ADVP (RB also)) (VP (VBZ contributes) (PP (TO to) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ putative) (JJ membrane-bound) (NN glucosyl) (NN transferase)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADVP (RB partially)) (VP (VBN controlled) (PP (IN by) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN stress) (NN response) (NN sigma) (NN factor)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN operon)))) (VP (VP (VBD was) (VP (VBN induced) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NN isoleucine)) (CC or) (NP (NN valine)))))) (PP (IN in) (NP (DT the) (NN growth) (NN medium))))) (CC and) (VP (VBD depended) (PP (IN upon) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (DT the) (NN sigma) (NN factor) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN sigma) (CD 54) (NN family))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Transcriptional) (NNS studies)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (DT the) (NN expression)) (PP (IN from) (NP (DT the) (NN _PROT2_) (NN promoter)))) (VP (VBZ is) (VP (VP (VBN induced) (PP (IN by) (NP (NN L-arabinose)))) (, ,) (VP (VBN repressed) (PP (IN by) (NP (NN glucose)))) (, ,) (CC and) (VP (ADVP (RB negatively)) (VBN regulated) (PP (IN by) (NP (NN _PROT1_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB transcriptionally)) (VP (VBN regulated) (PP (IN by) (NP (NP (NP (DT the) (JJ key) (JJ regulatory) (NN device)) (SBAR (WHNP (WDT that)) (S (VP (VBZ controls) (NP (NN sporulation) (NN initiation)))))) (, ,) (NP (DT the) (NN _PROT1_) (NN phosphorelay)))))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (JJ considerable) (NN evidence)) (VP (VBG implicating) (NP (NP (DT a) (NN mechanism)) (PP (IN of) (NP (NP (JJ post-translational) (NN control)) (SBAR (WHNP (WDT that)) (S (VP (VBZ governs) (NP (NP (DT the) (NP (NN activity)) (CC and) (NP (NN concentration))) (PP (IN of) (NP (NN sigmaH)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ _PROT2_) (NN transcription)) (ADVP (RB also)) (VP (VBZ requires) (NP (DT the) (NN DNA) (NN binding) (NN protein) (NN _PROT1_)))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NN _PROT2_)) (VP (VP (VBZ is) (VP (VBN transcribed) (PP (IN in) (NP (DT the) (NN forespore) (NN compartment))) (PP (IN by) (NP (NP (NN RNA) (NN polymerase)) (PP (IN with) (NP (DT the) (JJ forespore-specific) (NN _PROT1_))))))) (CC and) (VP (VBZ appears) (S (VP (TO to) (VP (VB give) (NP (DT a) (JJ monocistronic) (NN transcript)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Transcriptional) (NNS studies)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB strongly)) (VP (VBN induced) (PP (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NP (NN heat)) (, ,) (NP (NN ethanol)) (CC and) (NP (NN salt) (NN stress)))))) (CC or) (PP (IN after) (NP (NP (NN starvation)) (PP (IN for) (NP (NN glucose)))))) (PP (IN in) (NP (DT a) (ADJP (NN _PROT1_) (JJ _PROT1_)) (NN manner))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (VP (TO to) (VP (VB repress) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS promoters)))))) (CC and) (VP (ADVP (RB also)) (TO to) (VP (VB activate) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN promoter)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (VP (TO to) (VP (VB repress) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS promoters)))))) (CC and) (VP (ADVP (RB also)) (TO to) (VP (VB activate) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN promoter)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (VP (TO to) (VP (VB repress) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS promoters)))))) (CC and) (VP (ADVP (RB also)) (TO to) (VP (VB activate) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN promoter)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (VP (TO to) (VP (VB repress) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS promoters)))))) (CC and) (VP (ADVP (RB also)) (TO to) (VP (VB activate) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN promoter)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (VP (TO to) (VP (VB repress) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS promoters)))))) (CC and) (VP (ADVP (RB also)) (TO to) (VP (VB activate) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN promoter)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (VP (TO to) (VP (VB repress) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS promoters)))))) (CC and) (VP (ADVP (RB also)) (TO to) (VP (VB activate) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN promoter)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NN endospore) (NN formation)) (PP (IN in) (NP (FW Bacillus) (FW subtilis))))) (, ,) (NP (DT the) (NN DNA) (NN binding) (NN protein) (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN transcription)) (PP (IN from) (NP (NP (JJ several) (NNS promoters)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN used) (PP (IN by) (NP (NP (NN RNA) (NN polymerase)) (VP (VBG containing) (NP (NN _PROT2_))))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (DT a) (NN site)) (PP (IN on) (NP (NP (NP (CD one)) (PP (IN of) (NP (DT these) (NNS promoters)))) (, ,) (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ overlaps) (NP (PRP$ its) (CD -35) (NN region))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ proper) (NN localization)) (PP (IN of) (NP (NN SpoIVA)))) (VP (VBD required) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (QP (CD one) (CC or) (JJR more)) (NNS genes)) (SBAR (WHNP (WDT which)) (S (, ,) (PP (IN like) (NP (NN _PROT2_))) (, ,) (VP (VBP are) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (DT the) (NN mother) (NN cell) (NN transcription) (NN factor) (NN _PROT1_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN mutant))) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN gene)) (, ,) (SBAR (WHNP (WP$ whose) (NN transcription)) (S (VP (VBZ depends) (PP (IN on) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (DT the) (JJ phosphorylated) (NN _PROT2_) (NN protein)) (, ,) (NP (NN Spo0A~P)) (, ,) (NP (NP (DT a) (JJ major) (NN transcription) (NN factor)) (PP (IN during) (NP (NP (JJ early) (NNS stages)) (PP (IN of) (NP (NN sporulation)))))) (, ,)))))))))) (VP (VBD was) (ADVP (RB greatly)) (VP (VBN reduced) (PP (IN at) (NP (CD 43) (NNS degrees) (NN C))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN mutant))) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (, ,) (SBAR (WHNP (WP$ whose) (NN transcription)) (S (VP (VBZ depends) (PP (IN on) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (DT the) (JJ phosphorylated) (NN _PROT_) (NN protein)) (, ,) (NP (NN Spo0A~P)) (, ,) (NP (NP (DT a) (JJ major) (NN transcription) (NN factor)) (PP (IN during) (NP (NP (JJ early) (NNS stages)) (PP (IN of) (NP (NN sporulation)))))) (, ,)))))))))) (VP (VBD was) (ADVP (RB greatly)) (VP (VBN reduced) (PP (IN at) (NP (CD 43) (NNS degrees) (NN C))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN mutant))) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (, ,) (SBAR (WHNP (WP$ whose) (NN transcription)) (S (VP (VBZ depends) (PP (IN on) (NP (CC both) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CC and) (NP (NP (DT the) (JJ phosphorylated) (NN _PROT1_) (NN protein)) (, ,) (NP (NN Spo0A~P)) (, ,) (NP (NP (DT a) (JJ major) (NN transcription) (NN factor)) (PP (IN during) (NP (NP (JJ early) (NNS stages)) (PP (IN of) (NP (NN sporulation)))))) (, ,)))))))))) (VP (VBD was) (ADVP (RB greatly)) (VP (VBN reduced) (PP (IN at) (NP (CD 43) (NNS degrees) (NN C))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (NN shaA) (NN mutant))) (, ,) (NP (NP (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN at) (NP (NP (DT an) (JJ early) (NN stage)) (PP (IN of) (NP (NN sporulation)))))) (VP (VBD was) (ADJP (JJ sensitive) (PP (TO to) (NP (JJ external) (NN NaCl)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (NN shaA) (NN mutant))) (, ,) (NP (NP (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN expression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN at) (NP (NP (DT an) (JJ early) (NN stage)) (PP (IN of) (NP (NN sporulation)))))) (VP (VBD was) (ADJP (JJ sensitive) (PP (TO to) (NP (JJ external) (NN NaCl)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (NN shaA) (NN mutant))) (, ,) (NP (NP (ADJP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (JJ -dependent)) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN at) (NP (NP (DT an) (JJ early) (NN stage)) (PP (IN of) (NP (NN sporulation)))))) (VP (VBD was) (ADJP (JJ sensitive) (PP (TO to) (NP (JJ external) (NN NaCl)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN Primer) (NN extension)) (NNS experiments)) (CC and) (NP (NN Northern) (NN blot) (NN analysis))) (VP (VBP show) (SBAR (IN that) (S (S (NP (DT an) (JJ active) (NN _PROT1_) (NN promoter)) (VP (VBZ precedes) (NP (NN _PROT2_)))) (CC and) (S (NP (NN transcription)) (VP (VBZ is) (VP (VBN terminated) (PP (IN at) (NP (NP (DT the) (JJ putative) (JJ p-independent) (NN terminator)) (ADJP (JJ downstream) (PP (IN of) (NP (NN kdgT))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT1_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT1_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT2_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT1_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT1_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT2_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT1_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT1_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT2_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT2_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT2_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT1_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT1_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT2_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT1_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT1_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT2_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT1_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT1_AND_PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (CC and) (NN _PROT1_) (NNS genes)) (VP (VBP are) (VP (VBN recognized) (ADVP (RB primarily)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (PP (IN for) (NP (NP (NN RNA) (NN polymerase)) (, ,) (NP (NN _PROT_))))))))) (: ;) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN recognized) (ADVP (RB equally) (RB well)) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (JJ other) (JJ forespore-specific) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN _PROT_) (NN regulon)) (VP (VBZ includes) (NP (NP (NP (NP (DT a) (NN penicillin) (NN binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT a) (JJ co-transcribed) (NN amino) (NN acid) (NN racemase)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (NNS homologues)) (PP (IN of) (NP (NP (NN signal) (NN peptide) (NN peptidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))))) (, ,) (NP (NP (NN flotillin)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN ABC) (NNS transporters)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN non-haem) (NN bromoperoxidase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (NN epoxide) (NN hydrolase)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD three) (JJ small) (NNS peptides)) (PP (IN with) (NP (NP (JJ structural) (NNS similarities)) (PP (TO to) (NP (NN bacteriocin) (NN precursor) (NNS polypeptides))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ first) (NN stage)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ involves) (NP (NP (DT the) (NN phosphatase) (NN function)) (PP (IN of) (NP (NN _PROT_))))))) (, ,)) (VP (VP (VBZ depends) (PP (IN on) (NP (DT the) (NP (NN cell) (NN division)) (NN protein) (NN _PROT1_)))) (CC and) (VP (MD could) (VP (VB correspond) (PP (TO to) (NP (NP (DT the) (JJ _PROT2_) (NN assembly)) (PP (IN of) (NP (NN _PROT_))) (PP (IN into) (NP (NN E-rings)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ first) (NN stage)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ involves) (NP (NP (DT the) (NN phosphatase) (NN function)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,)) (VP (VP (VBZ depends) (PP (IN on) (NP (DT the) (NP (NN cell) (NN division)) (NN protein) (NN _PROT1_)))) (CC and) (VP (MD could) (VP (VB correspond) (PP (TO to) (NP (NP (DT the) (JJ _PROT_) (NN assembly)) (PP (IN of) (NP (NN _PROT_))) (PP (IN into) (NP (NN E-rings)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ first) (NN stage)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ involves) (NP (NP (DT the) (NN phosphatase) (NN function)) (PP (IN of) (NP (NN _PROT_))))))) (, ,)) (VP (VP (VBZ depends) (PP (IN on) (NP (DT the) (NP (NN cell) (NN division)) (NN protein) (NN _PROT1_)))) (CC and) (VP (MD could) (VP (VB correspond) (PP (TO to) (NP (NP (DT the) (JJ _PROT_) (NN assembly)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN into) (NP (NN E-rings)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ first) (NN stage)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ involves) (NP (NP (DT the) (NN phosphatase) (NN function)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,)) (VP (VP (VBZ depends) (PP (IN on) (NP (DT the) (NP (NN cell) (NN division)) (NN protein) (NN _PROT_)))) (CC and) (VP (MD could) (VP (VB correspond) (PP (TO to) (NP (NP (DT the) (JJ _PROT1_) (NN assembly)) (PP (IN of) (NP (NN _PROT_))) (PP (IN into) (NP (NN E-rings)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ first) (NN stage)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ involves) (NP (NP (DT the) (NN phosphatase) (NN function)) (PP (IN of) (NP (NN _PROT_))))))) (, ,)) (VP (VP (VBZ depends) (PP (IN on) (NP (DT the) (NP (NN cell) (NN division)) (NN protein) (NN _PROT_)))) (CC and) (VP (MD could) (VP (VB correspond) (PP (TO to) (NP (NP (DT the) (JJ _PROT1_) (NN assembly)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN into) (NP (NN E-rings)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ first) (NN stage)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ involves) (NP (NP (DT the) (NN phosphatase) (NN function)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,)) (VP (VP (VBZ depends) (PP (IN on) (NP (DT the) (NP (NN cell) (NN division)) (NN protein) (NN _PROT_)))) (CC and) (VP (MD could) (VP (VB correspond) (PP (TO to) (NP (NP (DT the) (JJ _PROT_) (NN assembly)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN into) (NP (NN E-rings)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Evidence)) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NN use)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ modified)) (CC and) (ADJP (JJ mutant))) (NNS forms)) (PP (IN of) (NP (DT the) (NN phosphatase) (NN protein))))))))) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ blocks) (NP (NP (DT the) (NN capacity)) (PP (IN of) (NP (JJ unphosphorylated) (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_)) (SBAR (IN until) (S (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ polar) (NN septum)))) (VP (VBZ is) (VP (VBN completed)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Evidence)) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NN use)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ modified)) (CC and) (ADJP (JJ mutant))) (NNS forms)) (PP (IN of) (NP (DT the) (NN phosphatase) (NN protein))))))))) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ blocks) (NP (NP (DT the) (NN capacity)) (PP (IN of) (NP (JJ unphosphorylated) (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_)) (SBAR (IN until) (S (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ polar) (NN septum)))) (VP (VBZ is) (VP (VBN completed)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Evidence)) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NN use)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ modified)) (CC and) (ADJP (JJ mutant))) (NNS forms)) (PP (IN of) (NP (DT the) (NN phosphatase) (NN protein))))))))) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ blocks) (NP (NP (DT the) (NN capacity)) (PP (IN of) (NP (JJ unphosphorylated) (NN _PROT1_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_)) (SBAR (IN until) (S (NP (NP (NN formation)) (PP (IN of) (NP (DT the) (JJ polar) (NN septum)))) (VP (VBZ is) (VP (VBN completed)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Cell-specific) (NN activation)) (PP (IN of) (NP (NN transcription) (NN factor) (NNS _PROT2_))) (PP (IN during) (NP (NP (NN sporulation)) (PP (IN in) (NP (FW Bacillus) (FW subtilis)))))) (VP (VBZ requires) (NP (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (JJ polar) (NN septum)))) (CC and) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NP (DT a) (NN serine) (NN phosphatase)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (ADJP (JJ located) (PP (IN in) (NP (DT the) (NN septum))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN _PROT1_) (NN phosphatase)) (ADVP (RB indirectly)) (VP (VBZ activates) (NP (NN _PROT_)) (PP (IN by) (S (VP (VBG dephosphorylating) (NP (NP (NP (DT a) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN in) (NP (DT the) (NN pathway))) (SBAR (WHNP (WDT that)) (S (VP (VBZ controls) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN transcription) (NN factor)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN _PROT1_) (NN phosphatase)) (ADVP (RB indirectly)) (VP (VBZ activates) (NP (NN _PROT2_)) (PP (IN by) (S (VP (VBG dephosphorylating) (NP (NP (NP (DT a) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN in) (NP (DT the) (NN pathway))) (SBAR (WHNP (WDT that)) (S (VP (VBZ controls) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN transcription) (NN factor)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN _PROT_) (NN phosphatase)) (ADVP (RB indirectly)) (VP (VBZ activates) (NP (NN _PROT2_)) (PP (IN by) (S (VP (VBG dephosphorylating) (NP (NP (NP (DT a) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN in) (NP (DT the) (NN pathway))) (SBAR (WHNP (WDT that)) (S (VP (VBZ controls) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN transcription) (NN factor)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (RBS Most) (JJ _PROT2_)) (NNS genes)) (, ,) (CC and) (NP (DT the) (NN _PROT_) (NN gene)) (, ,)) (VP (VBP are) (VP (VBN transcribed) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (RBS Most) (JJ _PROT_)) (NNS genes)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN gene)) (, ,)) (VP (VBP are) (VP (VBN transcribed) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (RBS Most) (JJ _PROT1_)) (NNS genes)) (, ,) (CC and) (NP (DT the) (NN _PROT2_) (NN gene)) (, ,)) (VP (VBP are) (VP (VBN transcribed) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Previously)) (, ,) (NP (PRP it)) (VP (VBD was) (VP (VBN shown) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VBZ inhibits) (NP (NP (NN transcription)) (PP (IN in) (NP (NP (FW vitro)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (VP (VBG encoding) (NP (NN sigmaK)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ initiates) (NP (NP (DT a) (JJ negative) (NN feedback) (NN loop)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NN repressor))) (S (VP (TO to) (VP (VB limit) (NP (NP (NN production)) (PP (IN of) (NP (NN _PROT_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN transcription)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ initiates) (NP (NP (DT a) (JJ negative) (NN feedback) (NN loop)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NN repressor))) (S (VP (TO to) (VP (VB limit) (NP (NP (NN production)) (PP (IN of) (NP (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ initiates) (NP (NP (DT a) (JJ negative) (NN feedback) (NN loop)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NN repressor))) (S (VP (TO to) (VP (VB limit) (NP (NP (NN production)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN transcription)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ initiates) (NP (NP (DT a) (JJ negative) (NN feedback) (NN loop)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NN repressor))) (S (VP (TO to) (VP (VB limit) (NP (NP (NN production)) (PP (IN of) (NP (NN _PROT_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ initiates) (NP (NP (DT a) (JJ negative) (NN feedback) (NN loop)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NN repressor))) (S (VP (TO to) (VP (VB limit) (NP (NP (NN production)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ _PROT_) (NN transcription)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ initiates) (NP (NP (DT a) (JJ negative) (NN feedback) (NN loop)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NN repressor))) (S (VP (TO to) (VP (VB limit) (NP (NP (NN production)) (PP (IN of) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT2_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT A) (JJ low) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NP (NN transcription)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))) (ADVP (FW in) (FW vitro)))) (, ,) (CC but) (S (NP (NP (DT a) (JJR higher) (NN level)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (IN near) (NP (DT the) (NN _PROT2_) (JJ transcriptional) (NN start) (NN site))) (, ,) (S (VP (TO to) (VP (VB act) (PP (IN as) (NP (DT a) (NN repressor))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (CD two) (NNS sites)) (SBAR (WHNP (WDT that)) (S (VP (VBP span) (NP (NP (DT the) (CD -35) (NN region)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN promoter)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT a) (JJ rising) (NN level)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (JJ sporulating) (NNS cells)))) (VP (MD may) (ADVP (RB first)) (VP (VBP activate) (NP (NP (NN _PROT2_) (NN transcription)) (PP (IN from) (NP (DT the) (JJ upstream) (NN site)))) (ADVP (RB then)) (VP (VB repress) (NP (NN transcription)) (SBAR (IN as) (S (NP (DT the) (JJ downstream) (NN site)) (VP (VBZ becomes) (VP (VBN occupied)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ _PROT1_) (NN promoter)) (PRN (-LRB- -LRB-) (NP (NN PW)) (-RRB- -RRB-))) (VP (VBZ precedes) (NP (NNP _PROT2_)) (, ,) (S (VP (VBG demonstrating) (SBAR (IN that) (S (NP (DT this) (NN transcription) (NN factor)) (VP (VBZ is) (ADVP (RB positively)) (VP (VBN autoregulated))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (DT The) (JJ _PROT1_) (NN promoter)) (VP (VBZ drives) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (PP (IN under) (NP (NN stress) (NNS conditions))) (CC and) (PP (IN after) (NP (NN glucose) (NN starvation))))))) (, ,) (IN whereas) (S (NP (DT a) (JJ _PROT2_) (NN promoter)) (VP (VBZ is) (ADJP (JJ responsible) (PP (IN for) (NP (NP (NN _PROT_) (NN transcription)) (PP (VBG following) (NP (NN amino) (NN acid) (NN limitation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (DT The) (JJ _PROT1_) (NN promoter)) (VP (VBZ drives) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (PP (IN under) (NP (NN stress) (NNS conditions))) (CC and) (PP (IN after) (NP (NN glucose) (NN starvation))))))) (, ,) (IN whereas) (S (NP (DT a) (JJ _PROT_) (NN promoter)) (VP (VBZ is) (ADJP (JJ responsible) (PP (IN for) (NP (NP (NN _PROT_) (NN transcription)) (PP (VBG following) (NP (NN amino) (NN acid) (NN limitation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (DT The) (JJ _PROT1_) (NN promoter)) (VP (VBZ drives) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (PP (IN under) (NP (NN stress) (NNS conditions))) (CC and) (PP (IN after) (NP (NN glucose) (NN starvation))))))) (, ,) (IN whereas) (S (NP (DT a) (JJ _PROT_) (NN promoter)) (VP (VBZ is) (ADJP (JJ responsible) (PP (IN for) (NP (NP (NN _PROT2_) (NN transcription)) (PP (VBG following) (NP (NN amino) (NN acid) (NN limitation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (DT The) (JJ _PROT_) (NN promoter)) (VP (VBZ drives) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (PP (IN under) (NP (NN stress) (NNS conditions))) (CC and) (PP (IN after) (NP (NN glucose) (NN starvation))))))) (, ,) (IN whereas) (S (NP (DT a) (JJ _PROT1_) (NN promoter)) (VP (VBZ is) (ADJP (JJ responsible) (PP (IN for) (NP (NP (NN _PROT_) (NN transcription)) (PP (VBG following) (NP (NN amino) (NN acid) (NN limitation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (DT The) (JJ _PROT_) (NN promoter)) (VP (VBZ drives) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (PP (IN under) (NP (NN stress) (NNS conditions))) (CC and) (PP (IN after) (NP (NN glucose) (NN starvation))))))) (, ,) (IN whereas) (S (NP (DT a) (JJ _PROT1_) (NN promoter)) (VP (VBZ is) (ADJP (JJ responsible) (PP (IN for) (NP (NP (NN _PROT2_) (NN transcription)) (PP (VBG following) (NP (NN amino) (NN acid) (NN limitation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (DT The) (JJ _PROT_) (NN promoter)) (VP (VBZ drives) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (PP (IN under) (NP (NN stress) (NNS conditions))) (CC and) (PP (IN after) (NP (NN glucose) (NN starvation))))))) (, ,) (IN whereas) (S (NP (DT a) (JJ _PROT_) (NN promoter)) (VP (VBZ is) (ADJP (JJ responsible) (PP (IN for) (NP (NP (NN _PROT2_) (NN transcription)) (PP (VBG following) (NP (NN amino) (NN acid) (NN limitation))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (NN gene) (NN product)) (, ,) (VP (VBG being) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (CC both) (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS regulons))))) (, ,)) (VP (MD might) (ADVP (RB negatively)) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN regulon)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_) (NN gene) (NN product)) (, ,) (VP (VBG being) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (CC both) (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS regulons))))) (, ,)) (VP (MD might) (ADVP (RB negatively)) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN regulon)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (NN gene) (NN product)) (, ,) (VP (VBG being) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (CC both) (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS regulons))))) (, ,)) (VP (MD might) (ADVP (RB negatively)) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN regulon)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT2_) (NN gene) (NN product)) (, ,) (VP (VBG being) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (CC both) (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS regulons))))) (, ,)) (VP (MD might) (ADVP (RB negatively)) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN regulon)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT_) (NN gene) (NN product)) (, ,) (VP (VBG being) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (CC both) (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS regulons))))) (, ,)) (VP (MD might) (ADVP (RB negatively)) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN regulon)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN _PROT1_) (NN gene) (NN product)) (, ,) (VP (VBG being) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (CC both) (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS regulons))))) (, ,)) (VP (MD might) (ADVP (RB negatively)) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN regulon)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NN addition) (TO to) (NP (DT the) (JJ typical) (ADJP (ADJP (JJ _PROT1_)) (, ,) (ADJP (JJ stress-)) (CC and) (ADJP (JJ starvation-inducible))) (NN pattern))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB also)) (VP (VBN induced) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN amino) (NN acid) (NN depletion)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADVP (RB solely)) (VP (VBN expressed) (PP (IN during) (NP (NP (NN sporulation)) (PP (IN from) (NP (NP (NP (NP (DT a) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (: -)) (CC and) (NP (JJ _PROT2_) (NN promoter))) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ located) (ADVP (RB immediately) (RB upstream) (PP (IN of) (NP (NN ftsY)))) (S (VP (VBP inside) (NP (DT the) (NN smc) (NN gene))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB solely)) (VP (VBN expressed) (PP (IN during) (NP (NP (NN sporulation)) (PP (IN from) (NP (NP (NP (NP (DT a) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (: -)) (CC and) (NP (JJ _PROT_) (NN promoter))) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ located) (ADVP (RB immediately) (RB upstream) (PP (IN of) (NP (NN ftsY)))) (S (VP (VBP inside) (NP (DT the) (NN smc) (NN gene))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADVP (RB solely)) (VP (VBN expressed) (PP (IN during) (NP (NP (NN sporulation)) (PP (IN from) (NP (NP (NP (NP (DT a) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (: -)) (CC and) (NP (JJ _PROT1_) (NN promoter))) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ located) (ADVP (RB immediately) (RB upstream) (PP (IN of) (NP (NN ftsY)))) (S (VP (VBP inside) (NP (DT the) (NN smc) (NN gene))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (CC both) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (CC and) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (CC both) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Dephosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (RB strictly) (JJ dependent) (PP (IN on) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (DT the) (JJ bivalent) (JJ metal) (NNS ions) (NP (NP (NN Mn2+)) (CC or) (NP (NN Mg2+)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (JJ stress-induced) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN expression)))) (VP (VBZ is) (ADJP (RB absolutely) (JJ dependent) (PP (IN on) (NP (NP (DT the) (JJ alternative) (NN sigma) (NN factor) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ controls) (NP (NP (DT a) (JJ large) (NN stationary-phase)) (CC and) (NP (NN stress) (NN regulon))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBD seemed) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN after) (NP (NN phosphate) (NN starvation))) (PP (PP (IN in) (NP (NP (DT the) (JJ wild) (NN type)) (PP (IN in) (NP (DT a) (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN manner))))) (CC and) (PP (IN in) (NP (DT the) (NN sigB) (NN mutant)))) (PP (ADVP (RB probably)) (IN via) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBD seemed) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN after) (NP (NN phosphate) (NN starvation))) (PP (PP (IN in) (NP (NP (DT the) (JJ wild) (NN type)) (PP (IN in) (NP (DT a) (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN manner))))) (CC and) (PP (IN in) (NP (DT the) (NN sigB) (NN mutant)))) (PP (ADVP (RB probably)) (IN via) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBD seemed) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN after) (NP (NN phosphate) (NN starvation))) (PP (PP (IN in) (NP (NP (DT the) (JJ wild) (NN type)) (PP (IN in) (NP (DT a) (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN manner))))) (CC and) (PP (IN in) (NP (DT the) (NN sigB) (NN mutant)))) (PP (ADVP (RB probably)) (IN via) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBD seemed) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN after) (NP (NN phosphate) (NN starvation))) (PP (PP (IN in) (NP (NP (DT the) (JJ wild) (NN type)) (PP (IN in) (NP (DT a) (ADJP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (JJ -dependent)) (NN manner))))) (CC and) (PP (IN in) (NP (DT the) (NN sigB) (NN mutant)))) (PP (ADVP (RB probably)) (IN via) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBD seemed) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN after) (NP (NN phosphate) (NN starvation))) (PP (PP (IN in) (NP (NP (DT the) (JJ wild) (NN type)) (PP (IN in) (NP (DT a) (ADJP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (JJ -dependent)) (NN manner))))) (CC and) (PP (IN in) (NP (DT the) (NN sigB) (NN mutant)))) (PP (ADVP (RB probably)) (IN via) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD seemed) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN after) (NP (NN phosphate) (NN starvation))) (PP (PP (IN in) (NP (NP (DT the) (JJ wild) (NN type)) (PP (IN in) (NP (DT a) (ADJP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (JJ -dependent)) (NN manner))))) (CC and) (PP (IN in) (NP (DT the) (NN sigB) (NN mutant)))) (PP (ADVP (RB probably)) (IN via) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS studies)) (PP (IN of) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NP (CD four)) (PP (IN of) (NP (DT the) (NNS kinases)))) (, ,) (NP (NP (NP (NNP KinA) (, ,) (NNP KinC)) (, ,) (NP (NP (NN KinD)) (PRN (-LRB- -LRB-) (NP (NN ykvD)) (-RRB- -RRB-))) (CC and) (NP (NNP KinE))) (PRN (-LRB- -LRB-) (NP (CD ykrQ)) (-RRB- -RRB-))))))) (, ,) (VP (VBG using) (NP (NN abrB) (NN transcription)) (PP (IN as) (NP (NP (DT an) (NN indicator)) (PP (IN of) (NP (NN Spo0A~P) (NN level)))))) (, ,)) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADJP (JJ responsible) (PP (IN for) (NP (NN _PROT_) (NN production)))) (PP (IN during) (NP (NP (DT the) (JJ exponential) (NN phase)) (PP (IN of) (NP (NN growth))))) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NP (NN KinA)) (CC and) (NP (NN KinB)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS studies)) (PP (IN of) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NP (CD four)) (PP (IN of) (NP (DT the) (NNS kinases)))) (, ,) (NP (NP (NP (NNP KinA) (, ,) (NNP KinC)) (, ,) (NP (NP (NN KinD)) (PRN (-LRB- -LRB-) (NP (NN ykvD)) (-RRB- -RRB-))) (CC and) (NP (NNP KinE))) (PRN (-LRB- -LRB-) (NP (CD ykrQ)) (-RRB- -RRB-))))))) (, ,) (VP (VBG using) (NP (NN abrB) (NN transcription)) (PP (IN as) (NP (NP (DT an) (NN indicator)) (PP (IN of) (NP (NN Spo0A~P) (NN level)))))) (, ,)) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADJP (JJ responsible) (PP (IN for) (NP (NN _PROT2_) (NN production)))) (PP (IN during) (NP (NP (DT the) (JJ exponential) (NN phase)) (PP (IN of) (NP (NN growth))))) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NP (NN KinA)) (CC and) (NP (NN KinB)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS studies)) (PP (IN of) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NP (CD four)) (PP (IN of) (NP (DT the) (NNS kinases)))) (, ,) (NP (NP (NP (NNP KinA) (, ,) (NNP KinC)) (, ,) (NP (NP (NN KinD)) (PRN (-LRB- -LRB-) (NP (NN ykvD)) (-RRB- -RRB-))) (CC and) (NP (NNP KinE))) (PRN (-LRB- -LRB-) (NP (CD ykrQ)) (-RRB- -RRB-))))))) (, ,) (VP (VBG using) (NP (NN abrB) (NN transcription)) (PP (IN as) (NP (NP (DT an) (NN indicator)) (PP (IN of) (NP (NN Spo0A~P) (NN level)))))) (, ,)) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADJP (JJ responsible) (PP (IN for) (NP (NN _PROT2_) (NN production)))) (PP (IN during) (NP (NP (DT the) (JJ exponential) (NN phase)) (PP (IN of) (NP (NN growth))))) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NP (NN KinA)) (CC and) (NP (NN KinB)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (DT the) (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN _PROT_) (NN gene)))) (VP (VBD depended) (PP (IN on) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (DT the) (ADJP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (JJ -dependent)) (NN _PROT2_) (NN gene)))) (VP (VBD depended) (PP (IN on) (NP (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (DT the) (ADJP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (JJ -dependent)) (NN _PROT2_) (NN gene)))) (VP (VBD depended) (PP (IN on) (NP (NN _PROT1_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Production)) (PP (IN of) (NP (NP (NN _PROT1_)) (ADJP (NP (QP (RB about) (CD 1)) (NN h)) (JJR earlier) (PP (IN than) (NP (JJ normal))))))) (VP (VBZ does) (VP (VB affect) (NP (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (SBAR (WHADVP (WRB when)) (S (VP (VBN phosphorylated)))) (VP (VBZ is) (NP (NP (DT an) (NN activator)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Production)) (PP (IN of) (NP (NP (NN _PROT1_)) (ADJP (NP (QP (RB about) (CD 1)) (NN h)) (JJR earlier) (PP (IN than) (NP (JJ normal))))))) (VP (VBZ does) (VP (VB affect) (NP (NP (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (SBAR (WHADVP (WRB when)) (S (VP (VBN phosphorylated)))) (VP (VBZ is) (NP (NP (DT an) (NN activator)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Production)) (PP (IN of) (NP (NP (NN _PROT_)) (ADJP (NP (QP (RB about) (CD 1)) (NN h)) (JJR earlier) (PP (IN than) (NP (JJ normal))))))) (VP (VBZ does) (VP (VB affect) (NP (NP (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (SBAR (WHADVP (WRB when)) (S (VP (VBN phosphorylated)))) (VP (VBZ is) (NP (NP (DT an) (NN activator)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT2_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT2_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT2_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT2_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT2_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT2_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT2_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT2_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN promoter)) (, ,) (PP (IN like) (NP (DT the) (NN _PROT1_) (NN promoter))) (, ,)) (VP (VBZ is) (VP (VBN believed) (S (VP (TO to) (VP (VB be) (VP (VBN recognized) (PP (IN by) (NP (NN _PROT_) (NN RNA) (NN polymerase)))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB inhibit) (NP (NN _PROT2_) (NN activity)) (PP (ADVP (RB late)) (IN in) (NP (NN sporulation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN mother) (NN cell) (NN compartment)) (PP (IN of) (NP (JJ sporulating) (NNS cells))))) (, ,) (NP (NP (NN expression)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN gene)) (, ,) (VP (VBG encoding) (NP (NP (DT the) (JJ earlier-acting) (NN sigma) (NN factor)) (, ,) (NP (NN sigmaE)) (, ,)))))) (VP (VBZ is) (ADVP (RB negatively)) (VP (VBN regulated) (PP (IN by) (NP (NP (DT the) (JJ later-acting) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT1_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (DT The) (NN finding) (SBAR (IN that) (S (NP (DT the) (NN _PROT2_) (NN operon)) (VP (VBZ is) (PP (IN under) (NP (NN _PROT1_) (NN control))))))) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN elimination)) (PP (IN of) (NP (JJ multidrug) (NNS compounds)))) (VP (MD might) (VP (VB be) (NP (NP (DT a) (JJ new) (NN function)) (PP (IN in) (NP (JJ multiple) (NN stress) (NN resistance)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT2_) (NN gene)) (VP (MD might) (VP (VB belong) (PP (TO to) (NP (NP (DT the) (VBG increasing) (NN number)) (PP (IN of) (NP (NP (JJ _PROT1_) (NNS genes)) (SBAR (WHNP (WP$ whose) (NNS orthologues)) (S (VP (VBP are) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NP (NNS sigmas)) (PP (IN in) (NP (FW Escherichia) (FW coli))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS regulons)) (VP (MD may) (VP (VBP fulfil) (NP (JJ similar) (NNS functions)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (CD Three) (JJ new) (JJ _PROT1_) (NNS genes)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (VP (VBG encoding) (NP (NP (NNS proteins)) (PP (IN with) (NP (ADJP (RB still) (JJ unknown)) (NNS functions)))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN described)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (CD Three) (JJ new) (JJ _PROT1_) (NNS genes)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (VP (VBG encoding) (NP (NP (NNS proteins)) (PP (IN with) (NP (ADJP (RB still) (JJ unknown)) (NNS functions)))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN described)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (CD Three) (JJ new) (JJ _PROT1_) (NNS genes)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (VP (VBG encoding) (NP (NP (NNS proteins)) (PP (IN with) (NP (ADJP (RB still) (JJ unknown)) (NNS functions)))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN described)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (CD Three) (JJ new) (JJ _PROT_) (NNS genes)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (VP (VBG encoding) (NP (NP (NNS proteins)) (PP (IN with) (NP (ADJP (RB still) (JJ unknown)) (NNS functions)))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN described)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (CD Three) (JJ new) (JJ _PROT_) (NNS genes)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (VP (VBG encoding) (NP (NP (NNS proteins)) (PP (IN with) (NP (ADJP (RB still) (JJ unknown)) (NNS functions)))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN described)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (CD Three) (JJ new) (JJ _PROT_) (NNS genes)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (VP (VBG encoding) (NP (NP (NNS proteins)) (PP (IN with) (NP (ADJP (RB still) (JJ unknown)) (NNS functions)))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN described)))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD was) (ADJP (JJ dependent) (PP (IN on) (NP (NN _PROT1_)))))) (, ,) (CC and) (S (NP (DT the) (NN mRNA)) (VP (VBD was) (ADJP (JJ detectable)) (PP (IN from) (NP (CD 2) (NN h))) (PP (IN after) (NP (NP (DT the) (NN cessation)) (PP (IN of) (NP (JJ logarithmic) (NN growth))))) (PRN (-LRB- -LRB-) (NP (NP (NN T2)) (PP (IN of) (NP (NN sporulation)))) (-RRB- -RRB-))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN transcribed) (PP (IN by) (NP (NN _PROT1_) (NN RNA) (NN polymerase))) (PP (IN from) (NP (NP (NN T4)) (PP (IN of) (NP (NN sporulation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADJP (JJ essential) (PP (IN for) (NP (NN _PROT_) (NN expression)))))) (, ,) (CC and) (S (NP (DT this) (NN gene)) (VP (VBD was) (VP (VBN transcribed) (PP (IN from) (NP (NP (NNP T5)) (PP (IN of) (NP (NN sporulation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADJP (JJ essential) (PP (IN for) (NP (NN _PROT2_) (NN expression)))))) (, ,) (CC and) (S (NP (DT this) (NN gene)) (VP (VBD was) (VP (VBN transcribed) (PP (IN from) (NP (NP (NNP T5)) (PP (IN of) (NP (NN sporulation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (CC Both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADJP (JJ essential) (PP (IN for) (NP (NN _PROT2_) (NN expression)))))) (, ,) (CC and) (S (NP (DT this) (NN gene)) (VP (VBD was) (VP (VBN transcribed) (PP (IN from) (NP (NP (NNP T5)) (PP (IN of) (NP (NN sporulation))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (NP (PRP we)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT_) (NN expression)) (PP (IN by) (S (VP (VBG preventing) (NP (NP (NN _PROT2_) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (PP (ADVP (RB possibly)) (IN through) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (NP (PRP we)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT2_) (NN expression)) (PP (IN by) (S (VP (VBG preventing) (NP (NP (NN _PROT_) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (PP (ADVP (RB possibly)) (IN through) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (NP (PRP we)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT_) (NN expression)) (PP (IN by) (S (VP (VBG preventing) (NP (NP (NN _PROT_) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (PP (ADVP (RB possibly)) (IN through) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (NN control) (NN region)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (NP (PRP we)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT2_) (NN expression)) (PP (IN by) (S (VP (VBG preventing) (NP (NP (NN _PROT1_) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (PP (ADVP (RB possibly)) (IN through) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (NP (PRP we)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT_) (NN expression)) (PP (IN by) (S (VP (VBG preventing) (NP (NP (NN _PROT1_) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (PP (ADVP (RB possibly)) (IN through) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (NN control) (NN region)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN From) (NP (DT these) (NNS results))) (NP (PRP we)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ regulates) (NP (NN _PROT1_) (NN expression)) (PP (IN by) (S (VP (VBG preventing) (NP (NP (NN _PROT_) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (PP (ADVP (RB possibly)) (IN through) (NP (NP (NN interaction)) (PP (IN with) (NP (DT the) (NN control) (NN region)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN shown) (ADVP (RB previously)) (SBAR (IN that) (S (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN driven) (PP (IN by) (NP (NP (DT an) (JJ alternative) (NN sigma) (NN factor)) (, ,) (NP (NN _PROT1_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN DNase) (CD I) (NN footprinting)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB strongly)) (PP (TO to) (NP (NP (CD two) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN promoter) (NN region)))))) (, ,) (VP (VBZ binds) (ADVP (RB weakly)) (PP (TO to) (NP (NP (CD one) (NN site)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN promoter)))))) (, ,) (CC and) (VP (VBZ does) (RB not) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NNP _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN DNase) (CD I) (NN footprinting)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB strongly)) (PP (TO to) (NP (NP (CD two) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN promoter) (NN region)))))) (, ,) (VP (VBZ binds) (ADVP (RB weakly)) (PP (TO to) (NP (NP (CD one) (NN site)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN promoter)))))) (, ,) (CC and) (VP (VBZ does) (RB not) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NNP _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN DNase) (CD I) (NN footprinting)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB strongly)) (PP (TO to) (NP (NP (CD two) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN promoter) (NN region)))))) (, ,) (VP (VBZ binds) (ADVP (RB weakly)) (PP (TO to) (NP (NP (CD one) (NN site)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN promoter)))))) (, ,) (CC and) (VP (VBZ does) (RB not) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NNP _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN DNase) (CD I) (NN footprinting)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB strongly)) (PP (TO to) (NP (NP (CD two) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN promoter) (NN region)))))) (, ,) (VP (VBZ binds) (ADVP (RB weakly)) (PP (TO to) (NP (NP (CD one) (NN site)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN promoter)))))) (, ,) (CC and) (VP (VBZ does) (RB not) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NNP _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN DNase) (CD I) (NN footprinting)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB strongly)) (PP (TO to) (NP (NP (CD two) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN promoter) (NN region)))))) (, ,) (VP (VBZ binds) (ADVP (RB weakly)) (PP (TO to) (NP (NP (CD one) (NN site)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN promoter)))))) (, ,) (CC and) (VP (VBZ does) (RB not) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NNP _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN DNase) (CD I) (NN footprinting)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VP (VBZ binds) (ADVP (RB strongly)) (PP (TO to) (NP (NP (CD two) (NNS sites)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN promoter) (NN region)))))) (, ,) (VP (VBZ binds) (ADVP (RB weakly)) (PP (TO to) (NP (NP (CD one) (NN site)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN promoter)))))) (, ,) (CC and) (VP (VBZ does) (RB not) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NNP _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT_) (, ,) (NN _PROT_) (, ,) (CC and) (NN _PROT_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT2_) (, ,) (NN _PROT_) (, ,) (CC and) (NN _PROT_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT_) (, ,) (NN _PROT2_) (, ,) (CC and) (NN _PROT_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT_) (, ,) (NN _PROT_) (, ,) (CC and) (NN _PROT2_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT2_) (, ,) (NN _PROT_) (, ,) (CC and) (NN _PROT_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT1_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT_) (, ,) (NN _PROT2_) (, ,) (CC and) (NN _PROT_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT1_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT_) (, ,) (NN _PROT_) (, ,) (CC and) (NN _PROT2_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT1_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT1_) (, ,) (NN _PROT2_) (, ,) (CC and) (NN _PROT_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT1_) (, ,) (NN _PROT_) (, ,) (CC and) (NN _PROT2_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Transcription)) (PP (IN of) (NP (DT the) (NNP _PROT_) (, ,) (NN _PROT1_) (, ,) (CC and) (NN _PROT2_) (NNS genes))) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase)))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NP (DT a) (ADJP (ADJP (JJ small)) (, ,) (ADJP (JJ DNA-binding))) (NN protein)) (VP (VBN called) (S (NP (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN transcription) (NNS experiments)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ differential) (NN pattern)) (PP (IN of) (NP (NN _PROT_) (NN gene) (NN expression)))) (VP (VBZ results) (PP (IN from) (NP (NP (NP (DT the) (JJ combined) (NN action)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT another) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN transcription) (NNS experiments)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ differential) (NN pattern)) (PP (IN of) (NP (NN _PROT2_) (NN gene) (NN expression)))) (VP (VBZ results) (PP (IN from) (NP (NP (NP (DT the) (JJ combined) (NN action)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT another) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN transcription) (NNS experiments)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ differential) (NN pattern)) (PP (IN of) (NP (NN _PROT2_) (NN gene) (NN expression)))) (VP (VBZ results) (PP (IN from) (NP (NP (NP (DT the) (JJ combined) (NN action)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (DT another) (NN transcription) (NN factor)) (, ,) (NP (NN _PROT1_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NNP _PROT_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NNP _PROT2_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NNP _PROT_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD activated) (NP (NNP _PROT_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NNP _PROT2_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NNP _PROT_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NNP _PROT_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NNP _PROT1_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NNP _PROT1_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ low) (NN concentration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD activated) (NP (NNP _PROT_) (NN transcription)) (PP (IN by) (NP (NP (NP (JJ final) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN RNA) (NN polymerase))) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (VP (VBD was) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PP (IN at) (NP (JJ low) (NN concentration)))) (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription)) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (ADVP (RB only) (RB partially)) (VP (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))) (CC and) (VP (VBD had) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NNP _PROT_) (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PP (IN at) (NP (JJ low) (NN concentration)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription)) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (ADVP (RB only) (RB partially)) (VP (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription))) (CC and) (VP (VBD had) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NNP _PROT_) (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PP (IN at) (NP (JJ low) (NN concentration)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription)) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (ADVP (RB only) (RB partially)) (VP (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))) (CC and) (VP (VBD had) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NNP _PROT2_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PP (IN at) (NP (JJ low) (NN concentration)))) (VP (VBD repressed) (NP (NN _PROT1_) (NN transcription)) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (ADVP (RB only) (RB partially)) (VP (VP (VBD repressed) (NP (NN _PROT2_) (NN transcription))) (CC and) (VP (VBD had) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NNP _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PP (IN at) (NP (JJ low) (NN concentration)))) (VP (VBD repressed) (NP (NN _PROT1_) (NN transcription)) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (ADVP (RB only) (RB partially)) (VP (VP (VBD repressed) (NP (NN _PROT_) (NN transcription))) (CC and) (VP (VBD had) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NNP _PROT2_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PP (IN at) (NP (JJ low) (NN concentration)))) (VP (VBD repressed) (NP (NN _PROT_) (NN transcription)) (, ,) (SBAR (IN whereas) (S (NP (DT a) (JJR higher) (NN concentration)) (ADVP (RB only) (RB partially)) (VP (VP (VBD repressed) (NP (NN _PROT1_) (NN transcription))) (CC and) (VP (VBD had) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NNP _PROT2_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (ADJP (FW in) (FW vitro)) (NN transcription) (NNS reactions)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN RNAP) (JJ holoenzyme) (NN activity))))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN observed) (S (VP (TO to) (VP (VB be) (ADJP (RBR more) (JJ sensitive) (PP (TO to) (NP (NN _PROT1_) (NN stimulation))) (SBAR (IN than) (S (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (ADJP (FW in) (FW vitro)) (NN transcription) (NNS reactions)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN RNAP) (JJ holoenzyme) (NN activity))))))) (, ,) (CC but) (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN observed) (S (VP (TO to) (VP (VB be) (ADJP (RBR more) (JJ sensitive) (PP (TO to) (NP (NN _PROT1_) (NN stimulation))) (SBAR (IN than) (S (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (ADJP (FW in) (FW vitro)) (NN transcription) (NNS reactions)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN RNAP) (JJ holoenzyme) (NN activity))))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN observed) (S (VP (TO to) (VP (VB be) (ADJP (RBR more) (JJ sensitive) (PP (TO to) (NP (NN _PROT1_) (NN stimulation))) (SBAR (IN than) (S (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (ADJP (FW in) (FW vitro)) (NN transcription) (NNS reactions)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN RNAP) (JJ holoenzyme) (NN activity))))))) (, ,) (CC but) (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN observed) (S (VP (TO to) (VP (VB be) (ADJP (RBR more) (JJ sensitive) (PP (TO to) (NP (NN _PROT_) (NN stimulation))) (SBAR (IN than) (S (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (ADJP (FW in) (FW vitro)) (NN transcription) (NNS reactions)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN RNAP) (JJ holoenzyme) (NN activity))))))) (, ,) (CC but) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN observed) (S (VP (TO to) (VP (VB be) (ADJP (RBR more) (JJ sensitive) (PP (TO to) (NP (NN _PROT_) (NN stimulation))) (SBAR (IN than) (S (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (ADJP (FW in) (FW vitro)) (NN transcription) (NNS reactions)))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN RNAP) (JJ holoenzyme) (NN activity))))))) (, ,) (CC but) (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN observed) (S (VP (TO to) (VP (VB be) (ADJP (RBR more) (JJ sensitive) (PP (TO to) (NP (NN _PROT_) (NN stimulation))) (SBAR (IN than) (S (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (DT a) (JJ translational) (NN ywhE-lacZ) (NN fusion)))))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VP (VBZ is) (ADJP (JJ sporulation-specific))) (, ,) (CC and) (VP (VBZ is) (VP (VP (VBN controlled) (ADVP (RB predominantly)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))))) (, ,) (CC and) (PP (TO to) (NP (DT a) (JJR lesser) (NN extent))) (PP (IN by) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (DT a) (JJ translational) (NN ywhE-lacZ) (NN fusion)))))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VP (VBZ is) (ADJP (JJ sporulation-specific))) (, ,) (CC and) (VP (VBZ is) (VP (VP (VBN controlled) (ADVP (RB predominantly)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))))) (, ,) (CC and) (PP (TO to) (NP (DT a) (JJR lesser) (NN extent))) (PP (IN by) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (DT a) (JJ translational) (NN ywhE-lacZ) (NN fusion)))))) (VP (VBD showed) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VP (VBZ is) (ADJP (JJ sporulation-specific))) (, ,) (CC and) (VP (VBZ is) (VP (VP (VBN controlled) (ADVP (RB predominantly)) (PP (IN by) (NP (NP (DT the) (JJ forespore-specific) (NN sigma) (NN factor)) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)))))) (, ,) (CC and) (PP (TO to) (NP (DT a) (JJR lesser) (NN extent))) (PP (IN by) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT the) (NNS results)) (VP (VBP support) (NP (DT the) (NN idea) (SBAR (IN that) (S (NP (NP (NN sequestration)) (PP (IN of) (NP (NN _PROT1_) (NN protein))) (PP (IN into) (NP (DT the) (NN prespore)))) (VP (VBZ plays) (NP (DT an) (JJ important) (NN role)) (PP (PP (IN in) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NN _PROT2_) (NN activation))))) (CC and) (PP (IN in) (NP (NP (NN coupling)) (PP (NP (DT this) (NN activation)) (TO to) (NP (NN septation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT1_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT2_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT1_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT2_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT1_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT1_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT1_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT2_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT1_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT1_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT1_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT1_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN controlled) (PP (IN by) (NP (NP (DT a) (JJ regulatory) (NN cascade)) (VP (VBG involving) (NP (NP (NP (DT an) (NN anti-sigma) (NN factor)) (, ,) (NP (NNP _PROT_) (, ,) (NP (DT an) (NN anti-anti-sigma) (NN factor) (, ,) (NN _PROT_) (, ,) (CC and) (NP (DT a) (JJ membrane-bound) (NN phosphatase))) (, ,) (NP (NNP _PROT_))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ converts) (NP (NP (DT the) (ADJP (ADJP (JJ inactive)) (, ,) (ADJP (JJ phosphorylated))) (NN form)) (PP (IN of) (NP (NN _PROT2_)))) (ADVP (RB back)) (PP (TO to) (NP (DT the) (JJ active) (NN form))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (DT the) (NN mutant)) (VP (VBD was) (ADJP (JJ unable) (S (VP (TO to) (VP (VB stimulate) (NP (NN transcription)) (PP (IN by) (NP (NP (JJ final) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN -RNA) (NN polymerase)) (PP (IN from) (NP (DT the) (JJ _PROT1_) (NN _PROT_) (NN operon) (NN promoter))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (DT the) (NN mutant)) (VP (VBD was) (ADJP (JJ unable) (S (VP (TO to) (VP (VB stimulate) (NP (NN transcription)) (PP (IN by) (NP (NP (JJ final) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN -RNA) (NN polymerase)) (PP (IN from) (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN operon) (NN promoter))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (NP (DT the) (NN mutant)) (VP (VBD was) (ADJP (JJ unable) (S (VP (TO to) (VP (VB stimulate) (NP (NN transcription)) (PP (IN by) (NP (NP (JJ final) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (NN -RNA) (NN polymerase)) (PP (IN from) (NP (DT the) (JJ _PROT_) (NN _PROT2_) (NN operon) (NN promoter))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT2_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT2_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT2_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT2_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT2_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT1_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT1_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT2_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT1_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT1_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT1_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT1_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT1_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT1_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT1_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT1_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT1_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT1_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT1_) (CD _PROT1_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT2_) (NN _PROT2_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT1_) (CD _PROT1_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT_) (NN _PROT_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN class)) (VP (VBZ includes) (NP (NP (NN AsiA) (NN form) (NN bacteriophage) (NN T4)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (ADJP (FW Escherichia) (FW coli)) (NN sigma) (CD 70)))))))) (: ;) (S (NP (NP (NP (NNP _PROT_)) (, ,) (ADJP (JJ present) (PP (IN in) (NP (NP (ADJP (CC both) (ADJP (JJ gram-positive)) (CC and) (ADJP (JJ gram-negative))) (NNS bacteria)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (DT the) (NNS flagella) (NP (NN sigma) (NN factor) (NN _PROT_) (CD _PROT_)))))))))) (: ;) (NP (NP (NNP _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NP (DT the) (JJ sporulation-specific) (NN sigma) (NN factor)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (, ,)) (PP (IN of) (NP (FW Bacillus) (FW subtilis)))))))) (: ;) (NP (NP (NNP _PROT_)) (PP (IN of) (NP (NP (FW B.) (FW subtilis)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NN stress) (NN response) (NN sigma) (NN factor) (NN _PROT1_) (NN _PROT1_)))))))) (: ;) (CC and) (NP (NNP _PROT_))) (, ,) (NP (NP (DT a) (JJ general) (NN regulator)) (PP (IN of) (NP (NP (DT the) (NN heat) (NN shock) (NN response)) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (NNS bacteria))) (VP (VBZ inhibits) (NP (DT the) (NN heat) (NN shock) (NN sigma) (NN factor) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Secondly)) (, ,) (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (DT the) (JJ first) (JJ compartment-specific) (NN transcription) (NN factor)) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))))) (PP (IN in) (NP (DT the) (NN prespore)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Localization)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (ADJP (JJ dependent) (PP (IN on) (NP (DT the) (NP (JJ essential) (NN cell) (NN division)) (NN protein) (NN _PROT1_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Cell) (NN specificity)) (VP (VBZ is) (ADVP (RB first)) (VP (VBN established) (PP (IN in) (NP (DT the) (NN forespore))) (PP (IN under) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN factor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (PRP itself)) (VP (VBN activated) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN serine) (NN phosphatase)) (, ,) (NP (NP (DT an) (NN enzyme)) (VP (VBN targeted) (PP (TO to) (NP (NP (DT the) (NN septum)) (PP (IN between) (NP (DT the) (CD two) (NNS cells))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT2_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT2_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT2_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT2_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB negatively)) (VP (VBZ controls) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN by) (S (VP (VBG stimulating) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG increasing) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN antisigma) (NN factor)) (SBAR (WHNP (WDT that)) (S (VP (VBZ inhibits) (NP (NN _PROT2_) (NN activity)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (ADJP (FW Bacillus) (FW subtilis)) (NN _PROT_) (NN operon)) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (CD two) (NN stress) (NN induction) (NNS pathways)) (VP (VBG relying) (PP (IN on) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (DT a) (NN class) (CD III) (NN stress) (NN induction) (NN mechanism)) (VP (VBG acting) (PP (IN at) (NP (DT a) (JJ _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (ADJP (FW Bacillus) (FW subtilis)) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (CD two) (NN stress) (NN induction) (NNS pathways)) (VP (VBG relying) (PP (IN on) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (DT a) (NN class) (CD III) (NN stress) (NN induction) (NN mechanism)) (VP (VBG acting) (PP (IN at) (NP (DT a) (JJ _PROT_) (NN promoter))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (ADJP (FW Bacillus) (FW subtilis)) (NN _PROT2_) (NN operon)) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (CD two) (NN stress) (NN induction) (NNS pathways)) (VP (VBG relying) (PP (IN on) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (DT a) (NN class) (CD III) (NN stress) (NN induction) (NN mechanism)) (VP (VBG acting) (PP (IN at) (NP (DT a) (JJ _PROT1_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (JJ global) (NN repressor)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN operon)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (JJ other) (NN class) (CD III) (NN heat) (NN shock) (NNS genes)) (, ,))))) (PP (IN by) (S (VP (VBG preventing) (NP (NP (JJ unstressed) (NN transcription)) (PP (IN from) (NP (CC either) (DT the) (ADJP (ADJP (JJ _PROT2_)) (CC or) (ADJP (JJ _PROT_))) (NN promoter)))))))) (CC and) (VP (MD might) (VP (VP (VB be) (VP (VBN inactivated))) (CC or) (VP (VBP dissociate) (PP (IN under) (NP (VBG inducing) (NN stress) (NNS conditions)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (JJ global) (NN repressor)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN operon)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (JJ other) (NN class) (CD III) (NN heat) (NN shock) (NNS genes)) (, ,))))) (PP (IN by) (S (VP (VBG preventing) (NP (NP (JJ unstressed) (NN transcription)) (PP (IN from) (NP (CC either) (DT the) (ADJP (ADJP (JJ _PROT_)) (CC or) (ADJP (JJ _PROT2_))) (NN promoter)))))))) (CC and) (VP (MD might) (VP (VP (VB be) (VP (VBN inactivated))) (CC or) (VP (VBP dissociate) (PP (IN under) (NP (VBG inducing) (NN stress) (NNS conditions)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN protein)) (VP (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (JJ global) (NN repressor)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN operon)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (JJ other) (NN class) (CD III) (NN heat) (NN shock) (NNS genes)) (, ,))))) (PP (IN by) (S (VP (VBG preventing) (NP (NP (JJ unstressed) (NN transcription)) (PP (IN from) (NP (CC either) (DT the) (ADJP (ADJP (JJ _PROT_)) (CC or) (ADJP (JJ _PROT_))) (NN promoter)))))))) (CC and) (VP (MD might) (VP (VP (VB be) (VP (VBN inactivated))) (CC or) (VP (VBP dissociate) (PP (IN under) (NP (VBG inducing) (NN stress) (NNS conditions)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (JJ global) (NN repressor)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN operon)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (JJ other) (NN class) (CD III) (NN heat) (NN shock) (NNS genes)) (, ,))))) (PP (IN by) (S (VP (VBG preventing) (NP (NP (JJ unstressed) (NN transcription)) (PP (IN from) (NP (CC either) (DT the) (ADJP (ADJP (JJ _PROT1_)) (CC or) (ADJP (JJ _PROT2_))) (NN promoter)))))))) (CC and) (VP (MD might) (VP (VP (VB be) (VP (VBN inactivated))) (CC or) (VP (VBP dissociate) (PP (IN under) (NP (VBG inducing) (NN stress) (NNS conditions)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (JJ global) (NN repressor)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN operon)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (JJ other) (NN class) (CD III) (NN heat) (NN shock) (NNS genes)) (, ,))))) (PP (IN by) (S (VP (VBG preventing) (NP (NP (JJ unstressed) (NN transcription)) (PP (IN from) (NP (CC either) (DT the) (ADJP (ADJP (JJ _PROT1_)) (CC or) (ADJP (JJ _PROT_))) (NN promoter)))))))) (CC and) (VP (MD might) (VP (VP (VB be) (VP (VBN inactivated))) (CC or) (VP (VBP dissociate) (PP (IN under) (NP (VBG inducing) (NN stress) (NNS conditions)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (DT the) (NN _PROT_) (NN protein)) (VP (VP (VBZ acts) (PP (IN as) (NP (NP (DT a) (JJ global) (NN repressor)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN operon)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (JJ other) (NN class) (CD III) (NN heat) (NN shock) (NNS genes)) (, ,))))) (PP (IN by) (S (VP (VBG preventing) (NP (NP (JJ unstressed) (NN transcription)) (PP (IN from) (NP (CC either) (DT the) (ADJP (ADJP (JJ _PROT_)) (CC or) (ADJP (JJ _PROT1_))) (NN promoter)))))))) (CC and) (VP (MD might) (VP (VP (VB be) (VP (VBN inactivated))) (CC or) (VP (VBP dissociate) (PP (IN under) (NP (VBG inducing) (NN stress) (NNS conditions)))))))))) (. .))) |ET|
