+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN _PROT2_) (NN turnover)) (PP (IN in) (NP (NP (NN endometrium)) (PP (IN of) (NP (NNS ewes)))))) (VP (VBZ is) (VP (VBN influenced) (PP (IN by) (NP (NP (NN stage)) (PP (IN of) (NP (NP (NP (DT the) (NN estrous) (NN cycle)) (, ,) (NP (NN pregnancy)) (, ,) (CC and) (NP (JJ intrauterine) (NN infusion))) (PP (IN of) (NP (NN ovine) (NN conceptus) (JJ secretory) (NNS proteins))))))))))) |ET|
+1 |BT| (S1 (S (NP (CD Three) (NNS experiments)) (PRN (-LRB- -LRB-) (NP (NNP Exp)) (-RRB- -RRB-)) (VP (VBD assessed) (NP (NP (DT the) (NN influence)) (PP (IN of) (NP (NP (NN stage)) (PP (IN of) (NP (NP (DT the) (NN estrous) (NN cycle)) (, ,) (NP (NN pregnancy)) (, ,) (CC and) (NP (NP (JJ intrauterine) (NN infusion)) (PP (IN of) (NP (NP (JJ ovine) (NN conceptus) (JJ secretory) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN oCSP)) (-RRB- -RRB-))))))))) (PP (IN on) (NP (NP (NN turnover)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (JJ putative) (NN second-messenger)) (PP (IN for) (NP (JJ _PROT2_) (NN secretion))) (PP (IN of) (NP (NN prostaglandin) (NN F2) (NN alpha)))) (-RRB- -RRB-))))))) (PP (IN in) (NP (NN ovine) (NN endometrium))) (PP (IN during) (NP (NP (NP (NN luteolysis)) (CC and) (NP (JJ maternal) (NN recognition))) (PP (IN of) (NP (NN pregnancy)))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT each) (NN Exp))) (, ,) (NP (ADJP (CD 100) (NN mg)) (NN endometrium)) (VP (VBD was) (VP (VP (VBN incubated) (, ,) (PP (IN in) (NP (NN duplicate))) (, ,) (PP (IN for) (NP (NP (CD 2) (NN h)) (PP (IN with) (NP (CD 10) (NN microCi) (NN [3H) (-RRB- -RSB-) (NN inositol)))))) (CC and) (VP (VBN treated) (PP (IN with) (NP (NP (ADJP (QP (CD 0) (CC or) (CD 100)) (NN nM)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 20) (NN min)))) (, ,) (ADVP (RB then))))) (S (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol) (NN mono-)) (, ,) (NP (NN bis-)) (, ,) (CC and) (NP (NP (NNS trisphosphates)) (PRN (-LRB- -LRB-) (NP (NP (NN IP1)) (, ,) (NP (NN IP2)) (, ,) (CC and) (NP (NN _PROT2_)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (VP (VBD were) (VP (VBN quantified)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS objectives)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD were) (S (VP (VP (TO to) (VP (VP (VB evaluate)) (CC and) (VP (VB compare) (NP (NP (DT the) (NNS actions)) (PP (IN of) (NP (NP (NP (NN endothelin-1)) (PRN (-LRB- -LRB-) (NP (NN ET-1)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))))) (PP (IN on) (NP (NP (NN 45Ca2+) (NN mobilization)) (PP (IN in) (NP (JJ permeabilized) (NN rat) (NN myometrial) (NNS cells))))))))) (CC and) (VP (TO to) (VP (VB examine) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NN inositol) (NN lipid) (NN cycle))) (PP (IN in) (NP (JJ intact) (NNS myocytes))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT All) (CD four) (NNS agonists)) (VP (VBD caused) (NP (NP (DT a) (JJ biphasic) (NN release)) (PP (IN of) (NP (NN 45Ca2+))) (PP (IN from) (NP (NP (JJ non-mitochondrial) (NN pool)) (PRN (-LRB- -LRB-) (NP (NN s)) (-RRB- -RRB-))))) (, ,) (PP (IN with) (NP (NP (DT the) (NN rank) (NN order)) (PP (IN of) (NP (NN potency))))))) (: :) (NP (NP (NN _PROT1_) (NN >) (NN PGF2) (NN alpha)) (NP (NN >) (NN ET-1) (NN >) (NN _PROT2_))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Endothelin-1)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NN _PROT2_) (NN _PROT2_) (NN accumulation)) (PP (IN at) (NP (NP (NNS concentrations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (SBAR (WHNP (WDT that)) (S (VP (VBD promoted) (NP (NN 45Ca2+) (NN efflux)))))))))))) (, ,) (IN whereas) (S (NP (NP (ADJP (QP (RB about) (CD 100) (NNS times)) (JJR higher)) (NNS concentrations)) (PP (IN of) (NP (NN PGF2) (NN alpha)))) (VP (VBD were) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (DT this) (NN signaling) (NN pathway)) (PP (IN in) (NP (JJ intact) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (VP (VBN concluded) (SBAR (IN that) (S (NP (NP (DT the) (JJ primary) (NN action)) (PP (IN of) (NP (NN PGF2) (NN alpha))) (PP (IN in) (NP (JJ myometrial) (NNS cells)))) (VP (VBZ is) (S (VP (TO to) (VP (VB enhance) (NP (NN Ca2+) (NN influx))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN ET-1))) (NNS receptors)) (VP (VBP are) (VP (VBN coupled) (PP (TO to) (NP (NN phospholipase) (NN C))) (, ,) (S (VP (VP (VBG generating) (NP (NN _PROT2_))) (CC and) (VP (VBG raising) (NP (NP (DT the) (JJ intracellular) (NN concentration)) (PP (IN of) (NP (JJ free) (NN Ca2+)))) (PP (IN from) (NP (ADJP (ADJP (JJ intracellular)) (CONJP (RB as) (RB well) (IN as)) (ADJP (JJ extracellular))) (NNS sources))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (DT a) (JJ biphasic) (NN increase)) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN Ca2+) (NN concentration)) (PP (IN of) (NP (NN porcine) (NN myometrial) (NNS cells)))))))) (: :) (NP (NP (NP (NN participation)) (PP (IN of) (NP (DT a) (ADJP (NN pertussis) (JJ toxin-insensitive)) (NN G-protein)))) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN Ca2+) (NN pool)) (, ,) (CC and) (NP (NN Ca2+) (NNS channels))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Administration)) (PP (IN of) (NP (NP (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 15) (NN sec)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN formation)) (PP (IN by) (NP (CD 61) (NN %)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN with) (NP (NP (NN pertussis) (NN toxin)) (PRN (-LRB- -LRB-) (NP (NP (NN PTX)) (, ,) (NP (CD 1) (NN microgram/ml))) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 2) (NN hr)))) (VP (VBD failed) (S (VP (TO to) (VP (VB alter) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT2_) (NN formation))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN U-73122)) (PRN (-LRB- -LRB-) (NP (CD 3) (NN microM)) (-RRB- -RRB-))) (ADVP (RB also)) (VP (VBD abolished) (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN formation))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ present) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (NN _PROT1_)) (VP (VBN given) (ADVP (ADVP (ADVP (RB subcutaneously)) (PRN (-LRB- -LRB-) (NP (NN SC)) (-RRB- -RRB-))) (CC and) (ADVP (ADVP (RB intracerebroventricularly)) (PRN (-LRB- -LRB-) (NP (NN ICV)) (-RRB- -RRB-)))))) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN glucagon)) (CC and) (NP (NN glucose)))))))))) (CC and) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (NP (DT these) (NNS variables)) (PP (IN of) (NP (NN suckling))))) (PP (IN in) (NP (JJ lactating) (NNS rats)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (JJ oxytocinergic) (NNS mechanisms)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Subcutaneous) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)) (ADVP (RB significantly))))) |ET|
+1 |BT| (S1 (S (NP (NP (CD Two) (NNS nanograms)) (S (NP (NP (NN _PROT1_)) (VP (VBN given) (NP (NN ICV)))) (VP (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)))) (CC but) (VP (VBD caused) (NP (NP (DT a) (JJ significant) (NN rise)) (PP (IN in) (NP (NN _PROT2_) (NNS levels)))) (PP (IN at) (NP (DT this) (NN time) (NN point))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT2_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT2_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT1_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT2_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT1_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Intracerebroventricular) (NNS injections)) (PP (IN of) (NP (ADJP (CD 200) (NN ng)) (NN _PROT1_)))) (VP (VBD caused) (NP (NP (DT a) (JJ significant) (NN rise)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN _PROT2_))) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (JJ nanogram) (NNS amounts)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN administered))))) (ADVP (RB ICV)) (VP (VBP cause) (NP (NP (DT a) (NN rise)) (PP (IN of) (NP (NN _PROT2_) (NNS levels))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN 8-OH-DPAT)) (ADVP (RB also)) (VP (VP (VBD increased) (NP (NN _PROT1_))) (CC and) (VP (VBD decreased) (NP (NP (NP (NN CCK)) (CC and) (NP (NN somatostatin))) (NNS levels))))) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT that)) (S (VP (VBD were) (VP (VBN blocked) (PP (IN by) (NP (NP (NN pretreatment)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN antagonist)))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN 8-OH-DPAT))) (PP (IN on) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN somatostatin)) (CC and) (NP (NN CCK))))))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ previous) (NNS experiments))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (PP (VBG following) (NP (NP (NN i.c.v.) (NN application)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBP are) (VP (VBN increased) (PP (IN through) (NP (DT a) (JJ cholinergic) (NN mechanism))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN influence)) (PP (IN of) (NP (NP (NN myrigalone) (NN B)) (, ,) (NP (NP (DT a) (NN _PROT1_)) (PP (IN from) (NP (NP (DT the) (JJ fruit) (NN exudate)) (PP (IN of) (NP (NNP Myrica) (FW gale) (FW L.)))))))) (PP (IN on) (NP (NP (ADJP (NN Cu) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN oxidation)) (PP (IN of) (NP (NP (JJ low) (NN density) (NN lipoprotein)) (PP (IN from) (NP (NN _PROT2_) (JJ fed) (NNS rabbits)))))))) (VP (VBD was) (VP (VBN investigated))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Immunohistochemical) (NN localization)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (ADJP (ADJP (JJ white)) (CC and) (ADJP (JJ brown))) (NN adipose) (NN tissue)))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB establish) (NP (NP (DT the) (NN cell) (NN type)) (VP (VBG expressing) (NP (NN _PROT1_))))))) (, ,) (NP (PRP we)) (ADVP (RB also)) (VP (VBD assessed) (NP (NP (NP (DT the) (NP (NN size)) (CC and) (NP (NN organization))) (PP (IN of) (NP (NP (NN lipid) (NNS droplets)) (, ,) (NP (NP (DT the) (JJ ultrastructural) (NNS features)) (PP (IN of) (NP (NN mitochondria)))) (, ,)))) (CC and) (NP (NP (DT the) (NP (NN presence)) (CC or) (NP (NN absence))) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT a) (JJ brown) (JJ fat-specific) (NN marker))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PP (IN of) (NP (JJ lean) (NNS animals))))) (, ,) (NP (NP (NP (JJ multilocular) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP)) (-RRB- -RRB-))) (JJ -positive) (NN brown) (NNS adipocytes)) (VP (VP (VBD had) (NP (JJ typical) (JJ brown) (NN mitochondria))) (CC and) (VP (VBD were) (ADJP (ADJP (JJ _PROT2_)) (, ,) (CC both) (PP (IN in) (NP (ADJP (ADJP (JJ fed)) (CC and) (ADJP (JJ fasted))) (NNS conditions)))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NP (DT the) (NN periphery)) (PP (IN of) (NP (DT the) (JJ interscapular) (JJ brown) (NN adipose) (NN tissue) (JJ depot))))) (, ,) (S (S (NP (NP (NP (ADJP (ADJP (JJ unilocular)) (, ,) (ADJP (JJ _PROT1_))) (NNS adipocytes)) (PRN (-LRB- -LRB-) (NP (NP (NN mean) (NN diameter)) (: :) (NP (CD 41.55) (NN microns))) (-RRB- -RRB-))) (PP (IN with) (NP (JJ white-type) (NN mitochondria)))) (VP (VBD were) (VP (VBN observed)))) (, ,) (CC and) (S (NP (DT these) (NNS cells)) (VP (VBD were) (NP (JJ _PROT2_))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (ADJP (ADJP (JJ obese)) (PRN (-LRB- -LRB-) (NP (NN db/db)) (-RRB- -RRB-))) (NNS animals))) (, ,) (NP (NN brown) (NN fat)) (VP (VBD was) (VP (VBN composed) (ADVP (RB mainly)) (PP (IN of) (NP (NP (JJ small) (ADJP (ADJP (JJ unilocular)) (, ,) (ADJP (JJ _PROT1_))) (NNS adipocytes)) (PRN (-LRB- -LRB-) (NP (NP (NN mean) (NN diameter)) (: :) (NP (CD 40.08) (NN microns))) (-RRB- -RRB-))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (ADVP (RB also)) (NP (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (JJ classical) (NN brown) (NNS adipocytes)) (VP (VBP differ) (PP (IN from) (NP (JJ white) (NNS adipocytes))) (, ,) (PP (CONJP (RB not) (RB only)) (PP (IN by) (NP (NP (PRP$ their) (NN morphology)) (CC and) (NP (NN _PROT1_) (NN expression)))) (, ,) (CONJP (CC but) (RB also)) (PP (IN by) (NP (NP (PRP$ their) (JJ apparent) (NN lack)) (PP (IN of) (NP (JJ detectable) (NN _PROT2_) (NN expression))))))))) |ET|
-1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (NP (CC or) (NP (NN _PROT2_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (NP (CC or) (NP (NN _PROT_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT2_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (NP (CC or) (NP (NN _PROT1_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT2_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT1_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT1_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT2_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT2_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN HvSPY) (NN coexpression)) (ADVP (RB largely)) (VP (VBD abolished) (NP (NP (JJ _PROT1_) (NN activity)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN promoter)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Signal) (NN transduction)) (PP (IN of) (NP (NN _PROT1_) (JJ _PROT1_) (JJ arachidonic) (NN acid) (NN release))) (PP (IN in) (NP (NN H9c2) (JJ cardiac) (NNS myoblasts)))) (: :) (NP (NP (NN role)) (PP (IN of) (NP (NN Ca2+)))) (CC and) (NP (NP (DT the) (ADJP (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_)) (NN activation)) (PP (IN of) (NP (NN p42) (JJ mitogen-activated) (NN protein) (NN kinase))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN Ca2+) (NN ionophore)) (, ,) (NP (NP (NN A23187)) (CC or) (NP (NN ionomycin))) (, ,)) (VP (VBD mimicked) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (SBAR (IN whereas) (S (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activator)) (, ,) (NP (NN TPA)) (, ,)) (ADVP (RB only)) (VP (VBD induced) (NP (NP (DT a) (JJ slight) (NN increase)) (PP (IN in) (NP (NN AA) (NN release)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT1_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT1_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ _PROT1_)) (CC or) (ADJP (JJ TPA-induced))) (NN activation)) (CC and) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (CD p42) (NN MAPK))))) (VP (VBD were) (VP (ADVP (RB completely)) (VBN blocked) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta))))))))) (, ,) (CC but) (S (ADVP (RB still)) (VP (VBD occurred) (, ,) (PP (ADVP (RB together)) (IN with) (NP (DT the) (JJ cytosolic) (NN PLA2) (NN mobility) (NN shift))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ external) (NN Ca2+))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN AA) (NN release)) (PP (IN in) (NP (NN H9c2) (NNS cells)))) (VP (VBZ is) (ADJP (JJ secondary) (PP (TO to) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN V1) (NN receptor/Gq) (NN protein/PLCP) (NN pathway))))))))) (, ,) (S (VP (VBG leading) (PP (TO to) (NP (NP (NP (DT an) (NN influx)) (PP (IN of) (NP (JJ extracellular) (NN Ca2+)))) (CC and) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT1_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT2_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT1_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT2_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT1_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT2_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Sympathetic) (NN inhibition)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN subtype) (NN expression)) (PP (IN in) (NP (JJ normal) (JJ fasting) (NNS rats))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB investigate) (NP (NP (JJ neural) (NNS effects)) (PP (IN on) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS UCPs)) (-RRB- -RRB-))))))))) (, ,) (S (NP (PRP we)) (VP (VBD studied) (NP (NP (ADJP (FW in) (FW vivo)) (NNS perturbations)) (VP (VBN intended) (S (VP (TO to) (VP (VB block) (NP (NP (JJ adrenergic) (NN input)) (PP (TO to) (NP (JJ peripheral) (NNS tissues))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT2_)) (, ,) (NP (NN _PROT1_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT1_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT2_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT1_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT2_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT1_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT2_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN modulation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VP (VBZ appears) (ADJP (JJ complex))) (CC and) (, ,) (PP (IN beyond) (NP (NP (DT a) (JJ causal) (NN effect)) (PP (IN of) (NP (NN SNA))) (ADVP (FW per) (FW se)))) (, ,) (VP (MD may) (VP (VB depend) (PP (IN on) (NP (NP (JJ concurrent) (NNS changes)) (PP (IN in) (NP (NP (NN plasma) (NN insulin)) (, ,) (NP (NN glucose)) (, ,) (CC and) (NP (JJ circulatory) (NNS hemodynamics))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (SBAR (IN in) (S (NP (NP (NN SN-56/OBR) (NNS cells)) (CC both) (NP (NP (NN CNTF)) (CC and) (NP (NN _PROT1_)))) (VP (VBP produce) (NP (NP (NP (NNS changes)) (PP (IN in) (NP (NN neurotransmitter)))) (CC and) (NP (NP (NN neuropeptide) (NN phenotype) (NN characteristic)) (PP (IN of) (NP (JJ cholinergic) (NNS neurons))))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NN choline) (NN acetyltransferase)) (CC and) (NP (JJ vasoactive) (JJ intestinal) (NN polypeptide))))) (, ,) (CC and) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_) (NN _PROT2_) (NN expression))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Possible) (NP (NP (JJ central) (JJ nervous) (NN system)) (PRN (-LRB- -LRB-) (NP (NN CNS)) (-RRB- -RRB-))) (NNS mechanisms)) (VP (MD could) (VP (VB mediate) (NP (DT these) (NNS responses)) (PP (IN in) (SBAR (IN that) (S (NP (NN leptin) (NNS receptors)) (VP (VBP are) (ADJP (JJ located) (PP (IN on) (NP (NP (JJ hypothalamic) (NNS neurons)) (SBAR (WHNP (WDT that)) (S (VP (VBP coexpress) (NP (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC or) (NP (NP (NN proopiomelanocortin)) (PRN (-LRB- -LRB-) (NP (JJ POMC)) (-RRB- -RRB-)))) (CC and) (NP (NP (DT both) (NNS peptides)) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN as) (NP (NP (NNS mediators)) (PP (IN of) (NP (NP (DT the) (NN CNS) (NN action)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ has) (VP (VBN been) (VP (VBN demonstrated) (S (VP (TO to) (VP (VP (VB decrease)) (CC or) (ADVP (RB down)) (VP (VB regulate) (NP (NN _PROT2_) (NN expression))) (CC and) (VP (VB increase) (NP (JJ POMC) (NN expression))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN 5-HT)) (CC and) (NP (NN _PROT1_))) (VP (VBP modulate) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB form) (NP (NP (DT a) (NN part)) (PP (IN of) (NP (NP (DT a) (JJ common) (NN output) (NN pathway)) (PP (IN for) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN appetite))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN studied) (NP (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN neomycin)) (, ,) (NP (NP (DT a) (JJ potent) (NN inhibitor)) (PP (IN of) (NP (NP (JJ inositol) (JJ phospholipid-specific) (NN phospholipase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))) (, ,))) (PP (IN on) (NP (NP (DT the) (NN germination)) (PP (IN of) (NP (NN rice) (NN seed)))))) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN aleurone) (NN layer)) (CC and) (NP (DT the) (JJ scutellar) (NNS tissues)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBD was) (VP (VBN shown) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ exogenous) (NN Ca2+))))) (, ,) (NP (NN neomycin)) (ADVP (RB markedly)) (VP (VP (VBD reduced) (NP (NP (DT the) (NP (NN germination) (NN speed)) (CC and) (NP (JJ seedling) (NN growth))) (PP (IN of) (NP (NN rice) (NNS seeds))))) (CC and) (VP (VBD inhibited) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT both) (JJ secretory) (NNS tissues)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB strongly)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN phosphoinositide-Ca2+) (NN signal) (NN transduction) (NN pathway)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NNS molecules)) (ADJP (RB closely) (JJ related) (PP (TO to) (NP (NP (DT the) (NN germination) (NNS processes)) (PP (IN of) (NP (NN rice) (NN seed))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN C75)) (VP (VP (VBD inhibited) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (JJ prophagic) (NN signal) (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN hypothalamus))))) (CC and) (VP (VBD acted) (PP (IN in) (NP (NP (DT a) (JJ _PROT2_) (NN manner)) (SBAR (WHNP (WDT that)) (S (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NN malonyl-coenzyme) (NN A)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (VP (VBG affecting) (NP (NP (NN lipid) (NN mobilization)) (PP (IN in) (NP (NN adipose) (NN tissue)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ current) (NNS investigations)))) (VP (VBD was) (VP (VBN focused) (PP (IN on) (NP (NP (DT the) (NN study)) (PP (IN of) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NN lipid) (NN mobilization))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ lipolytic) (NN rate)) (VP (VBD was) (VP (VBN assessed) (PP (IN through) (NP (NN glycerol) (NN release))) (PP (IN after) (NP (NP (NN incubation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN at) (NP (NP (NNS concentrations)) (VP (VBG ranging) (PP (IN from) (NP (NP (NP (NP (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -6)) (-RRB- -RRB-))) (TO to) (NP (CD 10) (PRN (-LRB- -LRB-) (NP (CD -12)) (-RRB- -RRB-)))) (NN M))) (PP (IN in) (NP (NP (VBN isolated) (NNS adipocytes)) (VP (VBN obtained) (PP (IN from) (NP (JJ female) (NNS rats))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NP (JJ equimolar) (NNS concentrations)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NP (CD 10) (-LRB- -LRB-) (CD -12) (-RRB- -RRB-)) (PP (TO to) (NP (CD 10) (-LRB- -LRB-) (CD -6) (-RRB- -RRB-) (NN M)))) (-RRB- -RRB-)))))) (NP (DT the) (VBN observed) (JJ lipolytic) (NN activity)) (VP (VBZ is) (ADJP (JJ comparable) (PP (TO to) (NP (DT the) (JJ basal) (JJ lipolytic) (NN activity)))) (, ,) (PP (IN except) (PP (IN at) (NP (NP (DT a) (NN concentration)) (PP (IN of) (NP (NP (NP (CD 10)) (PRN (-LRB- -LRB-) (NP (NN -9)) (-RRB- -RRB-))) (NN M)))))) (SBAR (WHADVP (WRB where)) (S (PP (IN upon) (NP (NP (DT a) (JJ significant) (NN increase)) (PP (IN in) (NP (NN lipolysis))))) (VP (VBZ is) (VP (VBN observed)))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Summing) (NP (NN up)))) (, ,) (NP (JJ new) (NN evidence)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB interact) (PP (IN in) (NP (DT a) (JJ homeostatic) (NN loop))) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN body-fat) (NN mass)) (CC and) (NP (NN energy) (NN balance))) (PP (CONJP (RB not) (RB only)) (PP (IN at) (NP (NP (DT the) (JJ central) (JJ nervous) (NN system)) (NN level))) (, ,) (CONJP (CC but) (RB also)) (ADVP (RB directly)) (PP (IN at) (NP (DT the) (JJ adipocyte) (NN level)))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Similarly)) (, ,) (NP (JJ central) (NN _PROT1_) (NN treatment)) (ADVP (RB also)) (VP (VBD had) (NP (DT a) (JJR greater) (NN effect)) (PP (IN in) (S (VP (VBG suppressing) (NP (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NN expression)) (PP (IN in) (NP (ADJP (ADJP (JJ young) (PRN (-LRB- -LRB-) (NP (CD -23+/-4) (NN %)) (-RRB- -RRB-))) (CONJP (IN than) (IN in)) (ADJP (JJ old) (PRN (-LRB- -LRB-) (NP (CD -8+/-4) (NN %)) (-RRB- -RRB-)))) (NNS rats)))))) (PP (VBN compared) (PP (IN with) (NP (PRP$ their) (JJ age-matched) (JJ pair-fed) (JJ treated) (NNS rats))))))) |ET|
