-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN study)) (VP (VBZ describes) (NP (NP (DT the) (NNS distributions)) (PP (IN of) (NP (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NP (NNS mRNAs)) (PP (IN for) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (. .)) (NP (NN collagen) (NNS types) (NP (NP (NP (NP (CD II)) (PRN (-LRB- -LRB-) (NP (NNP _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (CD III)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NP (DT a) (VBG growing) (`` ``) (NN cartilage) (NN cap) (NN '')) (PP (IN of) (NP (NN osteochondroma)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NP (JJ mesenchymal) (NNS cells)) (PP (IN in) (NP (DT the) (JJ outer) (JJ fibrous) (NN layer)))) (CC and) (NP (NP (NNS chondrocytes)) (PP (IN in) (NP (DT the) (JJ inner) (JJ cartilaginous) (NN matrix)))))) (, ,) (S (ADJP (JJ positive) (PP (IN for) (NP (NP (NNP _PROT2_) (CD _PROT2_)) (CC and) (NP (NNP _PROT_) (CD _PROT_)))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NP (JJ mesenchymal) (NNS cells)) (PP (IN in) (NP (DT the) (JJ outer) (JJ fibrous) (NN layer)))) (CC and) (NP (NP (NNS chondrocytes)) (PP (IN in) (NP (DT the) (JJ inner) (JJ cartilaginous) (NN matrix)))))) (, ,) (S (ADJP (JJ positive) (PP (IN for) (NP (NP (NNP _PROT_) (CD _PROT_)) (CC and) (NP (NNP _PROT2_) (CD _PROT2_)))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NP (JJ mesenchymal) (NNS cells)) (PP (IN in) (NP (DT the) (JJ outer) (JJ fibrous) (NN layer)))) (CC and) (NP (NP (NNS chondrocytes)) (PP (IN in) (NP (DT the) (JJ inner) (JJ cartilaginous) (NN matrix)))))) (, ,) (S (ADJP (JJ positive) (PP (IN for) (NP (NP (NNP _PROT1_) (CD _PROT1_)) (CC and) (NP (NNP _PROT2_) (CD _PROT2_)))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT This)) (VP (VP (VBZ is) (NP (NP (DT the) (JJ first) (NN study)) (S (VP (TO to) (VP (VBP provide) (NP (NP (JJ observational) (NN evidence)) (PP (IN of) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NN _PROT1_) (NN signaling))) (PP (IN in) (NP (NP (DT the) (NN pathogenesis)) (PP (IN of) (NP (NP (NN cartilage) (NN cap)) (PP (IN of) (NP (NN osteochondroma.))))))))))))))) (CC and) (VP (VBZ suggests) (NP (NP (DT the) (NN role)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN growth)) (PP (IN of) (NP (NP (JJ cartilage) (NN cap)) (PP (IN in) (NP (NN osteochondroma)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (NN involvement) (PP (IN in) (NP (NP (DT the) (JJ osteogenic) (NNS properties)) (PP (IN of) (NP (DT the) (NN HeLa) (NN cell) (NN line))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP postulate) (SBAR (IN that) (S (NP (NP (DT the) (NN mechanism)) (PP (IN of) (NP (NN bone) (NN induction)))) (VP (VBZ is) (VP (VBN based) (PP (IN on) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NN bone) (JJ morphogenetic) (NNS proteins) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN by) (NP (DT the) (JJ grafted) (NN HeLa) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)) (CC versus) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)) (CC versus) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)) (CC versus) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (CC versus) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)) (CC versus) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD investigated) (SBAR (IN whether) (S (NP (NP (DT the) (JJ chronic) (NN inflammation)) (CC and) (NP (NP (NN pain)) (VP (VBN experienced) (PP (IN by) (NP (NNS patients)))))) (VP (MD may) (VP (VB be) (VP (VBN caused) (PP (IN by) (NP (NP (DT an) (NN imbalance)) (PP (IN of) (NP (NP (JJ proinflammatory) (CC versus) (JJ anti-inflammatory) (NNS cytokines)) (PP (IN within) (NP (DT the) (NN prostate))) (, ,) (ADVP (RB namely)) (NP (NP (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)) (CC versus) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS MATERIALS)) (CC AND) (NP (NNS METHODS))) (: :) (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (JJ seminal) (NN plasma)) (PP (IN of) (NP (NP (NP (CD 31) (NNS patients)) (PP (IN with) (NP (JJ chronic) (JJ prostatitis-chronic) (JJ pelvic) (NN pain) (NN syndrome)))) (CC and) (NP (CD 14) (NNS controls))))))) (S (VP (VBG using) (NP (JJ enzyme-linked) (JJ immunosorbent) (NN assay)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NNS levels)) (VP (VBD were) (ADJP (RB statistically) (JJR greater)) (PP (IN in) (NP (NNS patients))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NNS levels)) (VP (VBD were) (ADJP (RB statistically) (JJR greater)) (PP (IN in) (NP (NNS patients))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS levels)) (VP (VBD were) (ADJP (RB statistically) (JJR greater)) (PP (IN in) (NP (NNS patients))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Isolation)) (PP (IN of) (NP (JJ human) (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN binding) (NN specificity)) (PP (IN with) (NP (NN _PROT2_) (CD _PROT2_))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD screened) (NP (NNS proteins)) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)))))) (, ,) (CC and) (VP (VBD cloned) (NP (NP (DT the) (JJ full-length) (NN cDNA)) (PP (IN of) (NP (JJ human) (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD encoded) (NP (NN 1225) (NN amino) (NNS acids))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Yeast) (JJ two-hybrid) (NN assay)) (, ,) (NP (NN GST) (NN binding) (NN assay)) (CC and) (NP (NN immunoprecipitation))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (DT a) (JJ hydrophilic) (NN loop) (NN region)) (PP (IN in) (NP (NP (DT the) (JJ endoproteolytic) (JJ C-terminal) (NN fragment)) (PP (IN of) (NP (NN _PROT2_))))))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Yeast) (JJ two-hybrid) (NN assay)) (, ,) (NP (NN GST) (NN binding) (NN assay)) (CC and) (NP (NN immunoprecipitation))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (DT a) (JJ hydrophilic) (NN loop) (NN region)) (PP (IN in) (NP (NP (DT the) (JJ endoproteolytic) (JJ C-terminal) (NN fragment)) (PP (IN of) (NP (NN _PROT_))))))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Yeast) (JJ two-hybrid) (NN assay)) (, ,) (NP (NN GST) (NN binding) (NN assay)) (CC and) (NP (NN immunoprecipitation))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBD interacted) (PP (PP (IN with) (NP (NP (DT a) (JJ hydrophilic) (NN loop) (NN region)) (PP (IN in) (NP (NP (DT the) (JJ endoproteolytic) (JJ C-terminal) (NN fragment)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (RB partly)) (VP (VBP differ) (PP (IN in) (NP (NN function)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD found) (S (NP (NP (DT another) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD found) (S (NP (NP (DT another) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD found) (S (NP (NP (DT another) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,)) (VP (VBD interacted) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (: :) (NP (NP (DT a) (JJ novel) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN death) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN yeast)))) (CC and) (VP (VBZ causes) (NP (NN cell) (NN death))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Ligation)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN cell) (NN surface) (NN receptor) (JJ _PROT1_AND_PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (VP (VBZ elicits) (NP (NP (DT a) (JJ characteristic) (VBN programmed) (NN death) (NN response)) (PP (IN in) (NP (JJ susceptible) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Ligation)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN cell) (NN surface) (NN receptor) (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ elicits) (NP (NP (DT a) (JJ characteristic) (VBN programmed) (NN death) (NN response)) (PP (IN in) (NP (JJ susceptible) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Ligation)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NP (NP (NN cell) (NN surface) (NN receptor) (JJ _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (VP (VBZ elicits) (NP (NP (DT a) (JJ characteristic) (VBN programmed) (NN death) (NN response)) (PP (IN in) (NP (JJ susceptible) (NNS cells)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (: :) (NP (NP (NN _PROT2_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT_)) (, ,) (PP (IN for) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (: :) (NP (NP (NN _PROT_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT2_)) (, ,) (PP (IN for) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (: :) (NP (NP (NN _PROT_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT_)) (, ,) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (: :) (NP (NP (NN _PROT1_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT2_)) (, ,) (PP (IN for) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (: :) (NP (NP (NN _PROT1_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT_)) (, ,) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT a) (JJ genetic) (NN selection)) (VP (VBN based) (PP (IN on) (NP (NP (JJ protein-protein) (NN interaction)) (PP (IN in) (NP (NN yeast))))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (CD two) (NN gene) (NNS products)) (SBAR (WHNP (WDT that)) (S (VP (VBP associate) (PP (IN with) (NP (NP (DT the) (JJ intracellular) (NN domain)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (: :) (NP (NP (NN _PROT_)) (NP (PRP itself))) (, ,) (CC and) (NP (DT a) (JJ novel) (ADJP (CD 74) (NN kDa)) (NN protein))) (S (NP (PRP we)) (VP (VBP have) (VP (VBN named) (NP (NN _PROT1_)) (, ,) (PP (IN for) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT2_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT1_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (ADVP (RB weakly)) (PP (PP (IN with) (NP (NP (NP (DT the) (NN _PROT_) (NN tumor) (NN necrosis) (NN factor) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (JJ intracellular) (NN domain))) (, ,) (CC but) (PP (RB not) (IN with) (NP (NP (DT a) (JJ mutant) (NN version)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (JJ murine) (NN lprcg) (NN mutation))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (NP (DT an) (JJ N-terminal) (NN region)) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NN protein) (NNS kinases)))))) (CC and) (NP (NP (DT a) (JJ C-terminal) (NN region)) (VP (VBG containing) (NP (NP (NP (DT a) (JJ cytoplasmic) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN death) (NN domain)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (DT the) (NN _PROT2_) (CC and) (NN _PROT_) (JJ intracellular) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ contains) (NP (NP (NP (DT an) (JJ N-terminal) (NN region)) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NN protein) (NNS kinases)))))) (CC and) (NP (NP (DT a) (JJ C-terminal) (NN region)) (VP (VBG containing) (NP (NP (NP (DT a) (JJ cytoplasmic) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN death) (NN domain)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (DT the) (NN _PROT_) (CC and) (NN _PROT2_) (JJ intracellular) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ contains) (NP (NP (NP (DT an) (JJ N-terminal) (NN region)) (PP (IN with) (NP (NP (NN homology)) (PP (TO to) (NP (NN protein) (NNS kinases)))))) (CC and) (NP (NP (DT a) (JJ C-terminal) (NN region)) (VP (VBG containing) (NP (NP (NP (DT a) (JJ cytoplasmic) (NN motif)) (PRN (-LRB- -LRB-) (NP (NN death) (NN domain)) (-RRB- -RRB-))) (ADJP (JJ present) (PP (IN in) (NP (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (JJ intracellular) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Molecular) (NN cloning)) (CC and) (NP (NN expression))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (NN _PROT1_)))))) (VP (VBZ reveals) (NP (NP (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (JJ transcriptional) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Molecular) (NN cloning)) (CC and) (NP (NN expression))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (NN _PROT1_)))))) (VP (VBZ reveals) (NP (NP (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (JJ transcriptional) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (JJ Molecular) (NN cloning)) (CC and) (NP (NN expression))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (NN _PROT_)))))) (VP (VBZ reveals) (NP (NP (NNS interactions)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (VBP mediate) (NP (JJ transcriptional) (NN activation)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT2_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT2_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Transcription) (NN factor) (NN _PROT_)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (QP (IN at) (JJS least) (CD eight)) (JJ _PROT2_) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS TAFs)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NP (NP (NN cloning)) (, ,) (NP (NN expression)) (, ,) (CC and) (NP (JJ biochemical) (NN characterization)))) (PP (IN of) (NP (NP (DT the) (JJ 32-kDa) (NN subunit)) (PP (IN of) (NP (JJ human) (PRN (-LRB- -LRB-) (NP (NN h)) (-RRB- -RRB-)) (NN _PROT1_))) (, ,) (VP (VBN termed) (S (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP find) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT the) (JJ human) (NN homologue)) (PP (IN of) (NP (NN Drosophila) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT1_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (JJ protein-protein) (NN interaction) (NNS assays)) (VP (VBP reveal) (SBAR (IN that) (S (SBAR (IN as) (S (VP (VBN observed) (PP (IN with) (NP (NN Drosophila) (NN _PROT_)))))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (DT the) (JJ C-terminal) (JJ 39-amino) (NN acid) (NN activation) (NN domain)) (PP (IN of) (NP (DT the) (JJ acidic) (NN transactivator) (JJ _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (DT the) (JJ general) (NN transcription) (NN factor) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT a) (JJ partial) (JJ recombinant) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NN _PROT2_)))) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG mediating) (NP (NP (ADJP (FW in) (FW vitro)) (JJ transcriptional) (NN activation)) (PP (IN by) (NP (DT the) (NN _PROT_) (NN activation) (NN domain)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT a) (JJ partial) (JJ recombinant) (NN _PROT1_) (NN complex)) (VP (VBG containing) (NP (NN _PROT_)))) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG mediating) (NP (NP (ADJP (FW in) (FW vitro)) (JJ transcriptional) (NN activation)) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN activation) (NN domain)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (NP (DT a) (JJ partial) (JJ recombinant) (NN _PROT_) (NN complex)) (VP (VBG containing) (NP (NN _PROT1_)))) (VP (VBD was) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG mediating) (NP (NP (ADJP (FW in) (FW vitro)) (JJ transcriptional) (NN activation)) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN activation) (NN domain)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Biochemical) (NNS studies)) (VP (VBD established) (SBAR (IN that) (S (NP (DT some) (NNS coactivators)) (VP (VBP are) (VP (VBN associated) (PP (IN with) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT_) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Biochemical) (NNS studies)) (VP (VBD established) (SBAR (IN that) (S (NP (DT some) (NNS coactivators)) (VP (VBP are) (VP (VBN associated) (PP (IN with) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Biochemical) (NNS studies)) (VP (VBD established) (SBAR (IN that) (S (NP (DT some) (NNS coactivators)) (VP (VBP are) (VP (VBN associated) (PP (IN with) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (S (VP (TO to) (VP (VB form) (NP (DT the) (NN _PROT2_) (NN complex))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (CD _PROT1_) (NN gene)) (VP (VBZ is) (ADJP (JJ identical) (PP (TO to) (NP (NP (NP (NP (DT a) (NN gene)) (, ,) (NP (NN _PROT2_)) (, ,)) (PRN (-LRB- -LRB-) (NP (JJ ref) (NN 7,8)) (-RRB- -RRB-))) (, ,) (VP (VBN implicated) (PP (IN in) (NP (JJ cell-cycle) (NN progression))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Recombinant) (CD _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (NP (NN _PROT2_)) (UCP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (PP (IN in) (NP (NN yeast))) (, ,))))) (CC and) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Recombinant) (CD _PROT1_)) (VP (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (NP (NN _PROT_)) (UCP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (PP (IN in) (NP (NN yeast))) (, ,))))) (CC and) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Recombinant) (CD _PROT_)) (VP (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (NP (NN _PROT1_)) (UCP (CC both) (ADVP (FW in) (FW vitro)) (CC and) (PP (IN in) (NP (NN yeast))) (, ,))))) (CC and) (VP (VBZ participates) (PP (IN in) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This) (JJS largest) (NN TAF)) (VP (MD may) (ADVP (RB therefore)) (VP (VB play) (NP (DT a) (JJ central) (NN role)) (PP (IN in) (NP (NN _PROT1_) (NN assembly))) (PP (IN by) (S (VP (VP (VBG interacting) (PP (IN with) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (JJ other) (NNS TAFs))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (VP (VBG serving) (S (VP (TO to) (VP (VB link) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NN transcription)))) (PP (TO to) (NP (DT the) (NN cell) (NN cycle))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (JJ functional) (NN analysis))) (PP (IN of) (NP (NN _PROT1_)))) (: :) (NP (NP (DT a) (JJ novel) (NN _PROT2_) (NN _PROT_)) (PP (IN with) (NP (JJ anti-cell) (NN death) (NN activity)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (JJ functional) (NN analysis))) (PP (IN of) (NP (NN _PROT1_)))) (: :) (NP (NP (DT a) (JJ novel) (NN _PROT2_) (NN _PROT2_)) (PP (IN with) (NP (JJ anti-cell) (NN death) (NN activity)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Cloning)) (CC and) (NP (JJ functional) (NN analysis))) (PP (IN of) (NP (NN _PROT_)))) (: :) (NP (NP (DT a) (JJ novel) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PP (IN with) (NP (JJ anti-cell) (NN death) (NN activity)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN protein) (NN interaction) (NN cloning) (NN technique)))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS cDNAs)) (SBAR (WHNP (WDT that)) (S (VP (VBP encode) (NP (NP (DT a) (JJ novel) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (, ,) (VP (VBN termed) (S (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN protein) (NN interaction) (NN cloning) (NN technique)))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS cDNAs)) (SBAR (WHNP (WDT that)) (S (VP (VBP encode) (NP (NP (DT a) (JJ novel) (JJ _PROT1_) (NN _PROT_)) (, ,) (VP (VBN termed) (S (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN protein) (NN interaction) (NN cloning) (NN technique)))) (, ,) (NP (PRP we)) (VP (VBD identified) (NP (NP (NNS cDNAs)) (SBAR (WHNP (WDT that)) (S (VP (VBP encode) (NP (NP (DT a) (JJ novel) (JJ _PROT1_) (NN _PROT1_)) (, ,) (VP (VBN termed) (S (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN protein)) (VP (VBZ shares) (NP (NP (DT no) (JJ significant) (NN homology)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (JJ other) (NN _PROT_) (NN family) (NNS proteins)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB form) (NP (NP (ADJP (JJ homo-))) (CC and) (NP (NNS heterodimers)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN protein)) (VP (VBZ shares) (NP (NP (DT no) (JJ significant) (NN homology)) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (JJ other) (NN _PROT2_) (NN family) (NNS proteins)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB form) (NP (NP (ADJP (JJ homo-))) (CC and) (NP (NNS heterodimers)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN protein)) (VP (VBZ shares) (NP (NP (DT no) (JJ significant) (NN homology)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (JJ other) (NN _PROT2_) (NN family) (NNS proteins)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD can) (VP (VB form) (NP (NP (ADJP (JJ homo-))) (CC and) (NP (NNS heterodimers)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NP (NN _PROT_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT2_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NP (NN _PROT_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NP (NN _PROT2_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (NN gene) (NN transfer) (NNS experiments)) (VP (VBG using) (NP (NP (DT a) (JJ human) (JJ lymphoid) (NN cell) (NN line)) (, ,) (NP (NN Jurkat)))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD provided) (NP (NP (ADJP (RB markedly) (VBN increased)) (NN protection)) (PP (IN from) (NP (NP (NN cell) (NN death)) (VP (VBN induced) (PP (IN by) (NP (NP (JJ several) (NNS stimuli)) (, ,) (PP (VBG including) (NP (NP (NN staurosporine)) (, ,) (NP (JJ anti-Fas) (NN antibody)) (, ,) (CC and) (NP (JJ cytolytic) (NN T) (NNS cells)))) (, ,) (ADJP (JJ relative) (PP (TO to) (NP (NP (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBD contained) (NP (NP (NN gene) (JJ transfer-mediated) (NNS elevations)) (PP (IN in) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NP (NN _PROT2_) (NN protein)) (ADVP (RB alone))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP indicate) (SBAR (IN that) (S (NP (NN bag-1)) (VP (VBZ represents) (NP (NP (DT a) (JJ new) (NN type)) (PP (IN of) (NP (JJ anti-cell) (NN death) (NN gene)))))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT some) (NNS routes)) (PP (IN of) (NP (NP (NN apoptosis) (NN induction)) (VP (ADVP (RB previously)) (VBN ascribed) (PP (TO to) (NP (JJ _PROT1_) (NNS pathways))))))) (VP (MD may) (ADVP (RB instead)) (VP (VB reflect) (NP (NP (DT a) (NN need)) (PP (IN for) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP indicate) (SBAR (IN that) (S (NP (NN bag-1)) (VP (VBZ represents) (NP (NP (DT a) (JJ new) (NN type)) (PP (IN of) (NP (JJ anti-cell) (NN death) (NN gene)))))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT some) (NNS routes)) (PP (IN of) (NP (NP (NN apoptosis) (NN induction)) (VP (ADVP (RB previously)) (VBN ascribed) (PP (TO to) (NP (JJ _PROT1_) (NNS pathways))))))) (VP (MD may) (ADVP (RB instead)) (VP (VB reflect) (NP (NP (DT a) (NN need)) (PP (IN for) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS findings)) (VP (VP (VBP indicate) (SBAR (IN that) (S (NP (NN bag-1)) (VP (VBZ represents) (NP (NP (DT a) (JJ new) (NN type)) (PP (IN of) (NP (JJ anti-cell) (NN death) (NN gene)))))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT some) (NNS routes)) (PP (IN of) (NP (NP (NN apoptosis) (NN induction)) (VP (ADVP (RB previously)) (VBN ascribed) (PP (TO to) (NP (JJ _PROT_) (NNS pathways))))))) (VP (MD may) (ADVP (RB instead)) (VP (VB reflect) (NP (NP (DT a) (NN need)) (PP (IN for) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN with) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (PP (IN by) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN with) (NP (NP (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN with) (NP (NP (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (JJ transcriptional) (NN activation)) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ few) (JJ general) (NN transcription) (NNS factors)) (, ,) (PP (IN in) (NP (NP (JJ particular) (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP have) (VP (VBN been) (VP (VBN found) (S (VP (TO to) (VP (VB bind) (NP (JJ transcriptional) (NNS activators))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT1_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT1_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT1_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NP (JJ general) (NN transcription) (NN factor)) (NP (NN _PROT_))) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT a) (NN target)) (PP (IN for) (NP (NP (NP (DT a) (JJ transcriptional) (NN activator)) (, ,) (NP (ADVP (RB namely)) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,)) (SBAR (WHNP (WDT which)) (S (VP (VBZ binds) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN promoter))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT2_) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT2_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT1_) (NN subunit)) (PP (IN of) (NP (NN _PROT_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT a) (NN yeast) (NN interaction) (NN assay)))) (, ,) (NP (PRP we)) (VP (VBP find) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ binds) (NP (NP (DT the) (NN _PROT_) (NN subunit)) (PP (IN of) (NP (NN _PROT1_))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (POS 's) (JJ transcriptional) (NN activation) (NN domain)) (VP (VBZ is) (NP (NP (DT the) (NN region)) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Further)) (, ,) (NP (NP (NN _PROT1_) (POS 's)) (JJ central) (JJ charged) (NN cluster) (NN domain)) (VP (VBZ is) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (PP (TO to) (NP (NP (NN _PROT2_) (POS 's)) (NN activation) (NN domain))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion)) (PP (IN of) (NP (DT this) (NN domain)))) (VP (VP (VBZ impairs) (NP (NN _PROT1_) (POS 's) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT2_) (NN transcription)) (ADVP (FW in) (FW vitro))))))) (CC but) (VP (VBZ has) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN protein) (POS 's) (JJ basal) (NN transcription) (NN activity)) (CC or) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion)) (PP (IN of) (NP (DT this) (NN domain)))) (VP (VP (VBZ impairs) (NP (NN _PROT1_) (POS 's) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT_) (NN transcription)) (ADVP (FW in) (FW vitro))))))) (CC but) (VP (VBZ has) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN protein) (POS 's) (JJ basal) (NN transcription) (NN activity)) (CC or) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Deletion)) (PP (IN of) (NP (DT this) (NN domain)))) (VP (VP (VBZ impairs) (NP (NN _PROT_) (POS 's) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT1_) (NN transcription)) (ADVP (FW in) (FW vitro))))))) (CC but) (VP (VBZ has) (NP (JJ little) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN protein) (POS 's) (JJ basal) (NN transcription) (NN activity)) (CC or) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB support) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT2_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT_) (NN transcription))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT1_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT2_) (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN of) (NP (NN _PROT_) (NN binding))) (PP (IN with) (NP (JJ transcriptional) (NN activation)))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN target)) (PP (IN for) (NP (JJ _PROT2_) (NN transcription))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Characterization)) (PP (IN of) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))) (PP (IN by) (S (VP (VBG using) (NP (DT the) (JJ two-hybrid) (NN system)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT_) (NN signaling)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT2_) (NN signaling)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT2_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VP (VBZ is) (NP (NP (DT a) (JJ major) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN _PROT1_))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN _PROT2_) (NN signaling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))) (, ,) (NP (NP (DT the) (NN nature)) (PP (IN of) (NP (DT the) (NN interaction)))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN defined))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))) (, ,) (NP (NP (DT the) (NN nature)) (PP (IN of) (NP (DT the) (NN interaction)))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN defined))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Although) (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))))) (, ,) (NP (NP (DT the) (NN nature)) (PP (IN of) (NP (DT the) (NN interaction)))) (VP (VBZ has) (RB not) (VP (VBN been) (VP (VBN defined))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (DT the) (JJ two-hybrid) (NN assay)) (PP (IN of) (NP (JJ protein-protein) (NN interaction))) (PP (IN in) (NP (DT the) (NN yeast) (NN Saccharomyces) (NN cerevisiae)))) (S (VP (TO to) (VP (VB study) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (DT the) (JJ two-hybrid) (NN assay)) (PP (IN of) (NP (JJ protein-protein) (NN interaction))) (PP (IN in) (NP (DT the) (NN yeast) (NN Saccharomyces) (NN cerevisiae)))) (S (VP (TO to) (VP (VB study) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (DT the) (JJ two-hybrid) (NN assay)) (PP (IN of) (NP (JJ protein-protein) (NN interaction))) (PP (IN in) (NP (DT the) (NN yeast) (NN Saccharomyces) (NN cerevisiae)))) (S (VP (TO to) (VP (VB study) (NP (NP (DT the) (NN interaction)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ forms) (NP (NP (DT a) (JJ specific) (NN complex)) (PP (IN with) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))) (SBAR (WHADVP (WRB when)) (S (NP (DT both)) (VP (VBP are) (VP (VBN expressed) (PP (IN as) (NP (NP (NN hybrid) (NNS proteins)) (PP (IN in) (NP (NN yeast) (NNS cells)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Lastly)) (, ,) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (PRP$ our) (NNS findings)) (PP (IN for) (NP (NN yeast) (NNS cells))))))) (, ,) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ unable) (S (VP (TO to) (VP (VB phosphorylate) (NP (NP (DT an) (NN _PROT2_) (NN protein)) (VP (VBG containing) (NP (NP (DT a) (NN deletion)) (PP (IN of) (NP (NN amino) (NNS acids) (NP (CD 45) (TO to) (CD 516))))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (JJ mammalian) (NN splicing) (NN factor) (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_)))) (CC and) (NP (NP (NN relation)) (PP (IN of) (NP (PRP$ its) (JJ 60-kD) (NN subunit))) (PP (TO to) (NP (NN yeast) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (JJ mammalian) (NN splicing) (NN factor) (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_) (NN _PROT_)))) (CC and) (NP (NP (NN relation)) (PP (IN of) (NP (PRP$ its) (JJ 60-kD) (NN subunit))) (PP (TO to) (NP (NN yeast) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Interaction)) (PP (IN of) (NP (JJ mammalian) (NN splicing) (NN factor) (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (NP (NP (NN relation)) (PP (IN of) (NP (PRP$ its) (JJ 60-kD) (NN subunit))) (PP (TO to) (NP (NN yeast) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT the) (NN assembly)) (PP (IN of) (NP (DT a) (NN prespliceosome))))) (, ,) (NP (NP (NN _PROT1_) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN snRNP)) (-RRB- -RRB-))) (VP (VBZ functions) (PP (IN in) (NP (NP (NN pre-messenger) (NN RNA) (-LRB- -LRB-) (NN mRNA) (-RRB- -RRB-) (NN splicing)) (PP (ADVP (RB together)) (IN with) (NP (NP (NP (NN splicing) (NNS factors)) (PRN (-LRB- -LRB-) (NP (NNS SFs)) (-RRB- -RRB-))) (NP (NN 3a)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (JJ several) (JJ other) (NNS proteins)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP it)) (VP (VBZ is) (VP (VBN shown) (SBAR (IN that) (S (NP (DT the) (NN _PROT1_) (NNS subunits)) (VP (VBP correspond) (PP (TO to) (NP (NP (CD three)) (PP (IN of) (NP (DT the) (NN 17S) (NN _PROT2_) (JJ _PROT2_) (NNS polypeptides))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT2_) (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT2_) (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT2_) (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT1_) (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT1_) (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT1_) (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_) (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB generate) (NP (NP (DT a) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NN 17S) (NN _PROT_) (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ suggests) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN incorporation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (DT the) (NN spliceosome))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT the) (NN 60-kilodalton) (NN subunit)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ related) (PP (TO to) (NP (DT the) (NN yeast) (NN splicing) (NN protein) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN Cdk-interacting) (NN protein) (NN _PROT2_)) (VP (VBZ is) (NP (NP (DT a) (JJ potent) (NN inhibitor)) (PP (IN of) (NP (NN G1) (JJ cyclin-dependent) (NNS kinases)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ cyclin-dependent) (NN kinase)) (NP (NN _PROT1_))) (VP (VP (VBZ associates) (PP (IN with) (NP (NNS _PROT2_) (NP (NP (NN _PROT2_)) (, ,) (NP (NN D)) (, ,) (CC and) (NP (NN E)))))) (CC and) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN control)) (PP (IN of) (NP (NP (DT the) (NN G1)) (PP (TO to) (NP (NN S) (NN phase) (NN transition))) (PP (IN in) (NP (NNS mammals)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ encodes) (NP (NP (DT a) (JJ novel) (ADJP (CD 21) (NN kd)) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN found) (PP (IN in) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS immunoprecipitates)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_) (NN _PROT2_) (NNS complexes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ is) (NP (NP (DT a) (ADJP (ADJP (JJ potent)) (, ,) (ADJP (JJ tight-binding))) (NN inhibitor)) (PP (IN of) (NP (NN Cdks))))) (CC and) (VP (MD can) (VP (VB inhibit) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_) (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_) (NN _PROT1_AND_PROT2_) (NNS complexes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Cotransfection) (NNS experiments)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (VP (VBP function) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ antagonistic)) (NN manner))) (S (VP (TO to) (VP (VB control) (NP (NN cell) (NN cycle) (NN progression)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VP (VBN cloned)) (CC and) (VP (VBN characterized)) (NP (NP (JJ human) (JJ _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_) (CD _PROT1_)) (-RRB- _PROT1_)) (NN _PROT1_)) (CC and) (NP (NP (DT a) (JJ second) (NN isoform)) (PP (IN of) (NP (JJ human) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (CD _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN deduced) (NN amino) (NN acid) (NNS sequences)) (PP (IN of) (NP (NP (JJ human) (NN alpha) (CD 1-)) (CC and) (NP (NN _PROT1_)) (NP (NN _PROT1_))))) (VP (VBP are) (ADJP (RB nearly) (JJ identical) (PP (TO to) (NP (NP (PRP$ their) (NNS homologues)) (PP (IN in) (NP (NN mouse)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ strong) (JJ functional) (NN conservation)) (PP (IN among) (NP (NP (DT the) (JJ individual) (NNS isoforms)) (, ,) (S (PP (ADVP (RB Much)) (IN like) (NP (NN _PROT2_) (NN _PROT2_))) (, ,) (NP (JJ human) (NN _PROT_) (NN _PROT_)) (VP (VP (VBZ has) (NP (JJ multiple) (NN transcript) (NNS classes))) (CC and) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB widely)) (, ,) (PP (IN although) (PP (IN in) (NP (NP (DT a) (JJ distinct) (NN pattern)) (PP (IN of) (NP (JJ relative) (NN abundance))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN deduced) (NN amino) (NN acid) (NNS sequences)) (PP (IN of) (NP (NP (JJ human) (NN alpha) (CD 1-)) (CC and) (NP (NN _PROT1_)) (NP (NN _PROT1_))))) (VP (VBP are) (ADJP (RB nearly) (JJ identical) (PP (TO to) (NP (NP (PRP$ their) (NNS homologues)) (PP (IN in) (NP (NN mouse)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ strong) (JJ functional) (NN conservation)) (PP (IN among) (NP (NP (DT the) (JJ individual) (NNS isoforms)) (, ,) (S (PP (ADVP (RB Much)) (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (JJ human) (NN _PROT2_) (NN _PROT2_)) (VP (VP (VBZ has) (NP (JJ multiple) (NN transcript) (NNS classes))) (CC and) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB widely)) (, ,) (PP (IN although) (PP (IN in) (NP (NP (DT a) (JJ distinct) (NN pattern)) (PP (IN of) (NP (JJ relative) (NN abundance))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (VBN deduced) (NN amino) (NN acid) (NNS sequences)) (PP (IN of) (NP (NP (JJ human) (NN alpha) (CD 1-)) (CC and) (NP (NN _PROT_)) (NP (NN _PROT_))))) (VP (VBP are) (ADJP (RB nearly) (JJ identical) (PP (TO to) (NP (NP (PRP$ their) (NNS homologues)) (PP (IN in) (NP (NN mouse)))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ strong) (JJ functional) (NN conservation)) (PP (IN among) (NP (NP (DT the) (JJ individual) (NNS isoforms)) (, ,) (S (PP (ADVP (RB Much)) (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (JJ human) (NN _PROT2_) (NN _PROT2_)) (VP (VP (VBZ has) (NP (JJ multiple) (NN transcript) (NNS classes))) (CC and) (VP (VBZ is) (VP (VBN expressed) (ADVP (RB widely)) (, ,) (PP (IN although) (PP (IN in) (NP (NP (DT a) (JJ distinct) (NN pattern)) (PP (IN of) (NP (JJ relative) (NN abundance))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Somatic) (NN cell) (NNS hybrids)) (CC and) (NP (JJ fluorescent) (ADJP (FW in) (FW situ)) (NN hybridization))) (VP (VBD were) (ADVP (DT both)) (VP (VBN used) (S (VP (TO to) (VP (VB determine) (NP (NP (PRP$ their) (JJ chromosomal) (NNS locations)) (: :) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PP (TO to) (NP (NN chromosome) (CD 16q22-23)))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (TO to) (NP (NN chromosome) (CD 20q11.2)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT1_) (NN _PROT1_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT1_) (NN _PROT1_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NN _PROT2_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (JJ _PROT_) (NN _PROT_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (PRP we)) (VP (VBD used) (PP (IN in) (NP (NP (ADJP (FW vitro) (VBN translated)) (NNS proteins)) (PP (IN in) (NP (DT an) (NN immunoprecipitation) (NN assay))))) (S (VP (TO to) (VP (VB show) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NN _PROT_) (NN _PROT_))) (, ,) (NP (CC both) (NP (NN beta) (CD 2-)) (CC and) (NP (NN _PROT_) (NN _PROT_))) (VP (VBP interact) (PP (IN with) (NP (NP (NP (NNS peptides)) (VP (VBG encoding) (NP (NP (DT the) (JJ syntrophin-binding) (NN region)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (, ,)))))) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ carboxy-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ has) (ADVP (RB previously)) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ cytoplasmic) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN complex)))) (, ,))) (PP (IN by) (NP (NP (ADJP (FW in) (FW vitro)) (JJ biochemical) (NNS studies)) (PP (JJ such) (IN as) (NP (NP (NN overlay) (NN assay)) (CC or) (NP (NN immunoprecipitation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ carboxy-terminal) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ has) (ADVP (RB previously)) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ cytoplasmic) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))) (, ,))) (PP (IN by) (NP (NP (ADJP (FW in) (FW vitro)) (JJ biochemical) (NNS studies)) (PP (JJ such) (IN as) (NP (NP (NN overlay) (NN assay)) (CC or) (NP (NN immunoprecipitation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ carboxy-terminal) (NN region)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ has) (ADVP (RB previously)) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB interact) (ADVP (RB directly)) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ cytoplasmic) (NN component)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN complex)))) (, ,))) (PP (IN by) (NP (NP (ADJP (FW in) (FW vitro)) (JJ biochemical) (NNS studies)) (PP (JJ such) (IN as) (NP (NP (NN overlay) (NN assay)) (CC or) (NP (NN immunoprecipitation))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (DT a) (JJ critical) (NN ligand) (NN binding) (NN determinant)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN Evidence)) (PP (IN for) (NP (NP (JJ common) (NN ligand) (NN binding) (NNS motifs)) (PP (IN in) (NP (DT the) (NN cytokine) (NN receptor) (NN family))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NN cytokine)) (CC and) (NP (NN growth)) (NP (NN factor) (NNS receptors)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP share) (NP (NP (JJ conserved) (NNS features)) (PP (IN in) (NP (PRP$ their) (ADJP (ADJP (JJ extracellular)) (CC and) (ADJP (JJ cytoplasmic))) (NNS domains)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NN cytokine)) (CC and) (NP (NN growth)) (NP (NN factor) (NNS receptors)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP share) (NP (NP (JJ conserved) (NNS features)) (PP (IN in) (NP (PRP$ their) (ADJP (ADJP (JJ extracellular)) (CC and) (ADJP (JJ cytoplasmic))) (NNS domains)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (NN cytokine)) (CC and) (NP (NN growth)) (NP (NN factor) (NNS receptors)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP share) (NP (NP (JJ conserved) (NNS features)) (PP (IN in) (NP (PRP$ their) (ADJP (ADJP (JJ extracellular)) (CC and) (ADJP (JJ cytoplasmic))) (NNS domains)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NP (JJ site-specific) (NN mutagenesis)) (PP (IN within) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_)))))) (S (VP (TO to) (VP (VB search) (PP (IN for) (NP (NP (NN amino) (NN acid) (NNS residues)) (VP (VBN involved) (PP (IN in) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NP (JJ site-specific) (NN mutagenesis)) (PP (IN within) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT1_)))))) (S (VP (TO to) (VP (VB search) (PP (IN for) (NP (NP (NN amino) (NN acid) (NNS residues)) (VP (VBN involved) (PP (IN in) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NP (JJ site-specific) (NN mutagenesis)) (PP (IN within) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (DT the) (NN _PROT_)))))) (S (VP (TO to) (VP (VB search) (PP (IN for) (NP (NP (NN amino) (NN acid) (NNS residues)) (VP (VBN involved) (PP (IN in) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (NNS bacteria))) (PP (IN as) (NP (NP (JJ soluble) (NN _PROT1_) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (CC and) (VP (VBN characterized) (PP (IN for) (NP (NN _PROT_) (NN binding) (NN activity))) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ different) (NNS assays))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (NNS bacteria))) (PP (IN as) (NP (NP (JJ soluble) (NN _PROT1_) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (CC and) (VP (VBN characterized) (PP (IN for) (NP (NN _PROT2_) (NN binding) (NN activity))) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ different) (NNS assays))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (NNS bacteria))) (PP (IN as) (NP (NP (JJ soluble) (NN _PROT_) (NN binding) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (CC and) (VP (VBN characterized) (PP (IN for) (NP (NN _PROT2_) (NN binding) (NN activity))) (PP (IN in) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (JJ different) (NNS assays))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Substitution)) (PP (IN of) (NP (NN phenylalanine))) (PP (IN at) (NP (NP (NN position) (CD 93)) (PRN (-LRB- -LRB-) (NP (NN Phe93)) (-RRB- -RRB-)))) (PP (IN with) (NP (NP (NN alanine)) (PRN (-LRB- -LRB-) (NP (NN F93A) (NN mutation)) (-RRB- -RRB-))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ drastic) (NN reduction)) (PP (IN in) (NP (NN _PROT1_) (NN binding))) (PP (IN in) (NP (DT the) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NP (DT the) (NN F93A) (NN mutation)) (PP (IN in) (NP (NP (JJ full-length) (NN _PROT1_)) (VP (VBN expressed) (PP (IN in) (NP (NN COS) (NNS cells))))))) (VP (VBD abolished) (NP (JJ detectable) (NN _PROT2_) (NN binding)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN Phe93)) (VP (VBZ is) (NP (NP (DT a) (JJ critical) (NN _PROT1_) (NN binding) (NN determinant)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (JJ cytokine-activated) (NN tyrosine) (NN kinase) (NN _PROT1_)) (VP (VBZ activates) (NP (NN _PROT2_)) (PP (IN in) (NP (DT a) (JJ _PROT_) (NN manner))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ cytokine-activated) (NN tyrosine) (NN kinase) (NN _PROT1_)) (VP (VBZ activates) (NP (NN _PROT_)) (PP (IN in) (NP (DT a) (JJ _PROT2_) (NN manner))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ cytokine-activated) (NN tyrosine) (NN kinase) (NN _PROT_)) (VP (VBZ activates) (NP (NN _PROT1_)) (PP (IN in) (NP (DT a) (JJ _PROT2_) (NN manner))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT_) (NN _PROT_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT_) (NN _PROT_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN Janus) (NN kinase) (NN superfamily))))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB interact) (ADVP (RB functionally)) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ central) (NN component)) (PP (IN of) (NP (DT the) (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN signal) (NN transduction) (NN pathway)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT1_) (NN _PROT1_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN activity)) (PP (IN toward) (NP (NN _PROT_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT1_) (NN _PROT_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NP (JJ several) (JJ other) (NNS cytokines)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN known) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_))))))))))) (VP (VBD were) (ADVP (RB also)) (VP (VBN found) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN activity)) (PP (IN toward) (NP (NN _PROT2_))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ baculovirus) (NN coexpression) (NN system))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ baculovirus) (NN coexpression) (NN system))) (, ,) (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ baculovirus) (NN coexpression) (NN system))) (, ,) (NP (NN _PROT_)) (VP (VBD was) (VP (VBN activated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Under) (NP (DT these) (NNS conditions))) (, ,) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Under) (NP (DT these) (NNS conditions))) (, ,) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Under) (NP (DT these) (NNS conditions))) (, ,) (NP (NP (DT a) (JJ ternary) (NN complex)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBD was) (VP (VBN observed)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN kinase) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN _PROT_))))) (, ,) (NP (NP (NN coexpression)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT an) (JJ overall) (NN decrease)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN kinase) (NN activity))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBD phosphorylated) (NP (NN _PROT2_)) (PP (IN at) (NP (NP (NNS sites)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBD phosphorylated) (NP (NN _PROT_)) (PP (IN at) (NP (NP (NNS sites)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT_)) (VP (VBD phosphorylated) (NP (NN _PROT1_)) (PP (IN at) (NP (NP (NNS sites)) (ADJP (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ mammalian) (NNS cells)) (VP (VBN treated) (PP (IN with) (NP (CC either) (NP (NN erythropoietin)) (CC or) (NP (NN interferon-gamma))))))) (, ,) (NP (NP (DT a) (JJ small) (NN fraction)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD coimmunoprecipitated) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NNS lysates)) (PP (IN of) (NP (NP (NNS cells)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBD was) (VP (VBN activated) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (PRP$ its) (NN state)) (PP (IN of) (NP (NN tyrosine) (NN phosphorylation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ mammalian) (NNS cells)) (VP (VBN treated) (PP (IN with) (NP (CC either) (NP (NN erythropoietin)) (CC or) (NP (NN interferon-gamma))))))) (, ,) (NP (NP (DT a) (JJ small) (NN fraction)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD coimmunoprecipitated) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NNS lysates)) (PP (IN of) (NP (NP (NNS cells)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN activated) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (PRP$ its) (NN state)) (PP (IN of) (NP (NN tyrosine) (NN phosphorylation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (JJ mammalian) (NNS cells)) (VP (VBN treated) (PP (IN with) (NP (CC either) (NP (NN erythropoietin)) (CC or) (NP (NN interferon-gamma))))))) (, ,) (NP (NP (DT a) (JJ small) (NN fraction)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD coimmunoprecipitated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NNS lysates)) (PP (IN of) (NP (NP (NNS cells)) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBD was) (VP (VBN activated) (SBAR (IN as) (S (VP (VBN judged) (PP (IN by) (NP (NP (PRP$ its) (NN state)) (PP (IN of) (NP (NN tyrosine) (NN phosphorylation)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP cooperate) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP cooperate) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP cooperate) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN protein) (NNS phosphatases) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))) (CC and) (VP (VBZ disrupts) (NP (DT a) (NN G2/M) (JJ cell-cycle) (NN checkpoint))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN protein) (NNS phosphatases) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ disrupts) (NP (DT a) (NN G2/M) (JJ cell-cycle) (NN checkpoint))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN protein) (NNS phosphatases) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))) (CC and) (VP (VBZ disrupts) (NP (DT a) (NN G2/M) (JJ cell-cycle) (NN checkpoint))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT1_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NP (NP (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (DT the) (NN protein) (NN _PROT_)) (VP (VBD interacted) (PP (IN with) (NP (NN protein) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NP (NP (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (JJ mammalian) (NNS cells)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN oncogene)) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (NP (NP (NNS targets)) (PP (IN for) (NP (NP (JJ oncogenic) (NNS viruses)) (CC and) (NP (JJ chemical) (NN tumour) (NNS promoters))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN oncogene)) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (NP (NP (NNS targets)) (PP (IN for) (NP (NP (JJ oncogenic) (NNS viruses)) (CC and) (NP (JJ chemical) (NN tumour) (NNS promoters))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN oncogene)) (SBAR (WHNP (WDT that)) (S (VP (VBZ targets) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (NP (NP (NNS targets)) (PP (IN for) (NP (NP (JJ oncogenic) (NNS viruses)) (CC and) (NP (JJ chemical) (NN tumour) (NNS promoters))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Analysis)) (PP (IN of) (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT2_) (NN _PROT_) (NN binding) (NN interface))) (PP (IN at) (NP (DT the) (NN amino) (NN acid) (NN level)))) (: :) (NP (NP (JJ proposed) (NN mechanism)) (PP (IN of) (NP (NN interaction)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Analysis)) (PP (IN of) (NP (DT the) (JJ human) (NN _PROT1_) (NN _PROT2_) (NN _PROT2_) (NN binding) (NN interface))) (PP (IN at) (NP (DT the) (NN amino) (NN acid) (NN level)))) (: :) (NP (NP (JJ proposed) (NN mechanism)) (PP (IN of) (NP (NN interaction)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Analysis)) (PP (IN of) (NP (DT the) (JJ human) (NN _PROT_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN binding) (NN interface))) (PP (IN at) (NP (DT the) (NN amino) (NN acid) (NN level)))) (: :) (NP (NP (JJ proposed) (NN mechanism)) (PP (IN of) (NP (NN interaction)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBZ is) (NP (NP (DT the) (ADJP (ADJP (JJ initial)) (CC and) (ADJP (RBS most) (JJ specific))) (NN step)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN signaling) (NN pathway)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (DT the) (JJ human) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN _PROT_) (NN binding) (NN interface)) (PP (IN by) (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (JJ molecular) (NN modelling)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (DT the) (JJ human) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN _PROT2_) (NN binding) (NN interface)) (PP (IN by) (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (JJ molecular) (NN modelling)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (DT the) (JJ human) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (NN _PROT2_) (NN binding) (NN interface)) (PP (IN by) (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (JJ molecular) (NN modelling)) (CC and) (NP (JJ site-directed) (NN mutagenesis)))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (VBG Following) (NP (DT this) (NN hypothesis))) (, ,) (NP (PRP we)) (VP (VBN altered) (PP (IN in) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS residues)) (VP (VBN predicted) (S (VP (VP (TO to) (VP (VB reside) (PP (IN in) (NP (DT the) (NN contact) (NN region))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT each) (JJ other))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD studied) (NP (NP (DT the) (NN capacity)) (PP (IN of) (NP (DT these) (NNS mutants))) (S (VP (TO to) (VP (VB form) (NP (NP (DT an) (NN _PROT1_AND_PROT2_) (NN complex)) (CC and) (NP (PRP$ their) (NN ability) (S (VP (TO to) (VP (VB transduce) (NP (DT the) (NN signal))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Mutagenesis) (NNS studies)) (PP (IN of) (NP (NP (DT the) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN Establishment)) (PP (IN of) (NP (JJ structure-function) (NNS relationships))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Mutagenesis)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBZ permits) (NP (NP (NN analysis)) (PP (IN of) (NP (NP (DT the) (NN contribution)) (SBAR (WHNP (WDT that)) (S (NP (JJ individual) (NN amino) (NN acid) (NNS residues)) (VP (VBP make) (PP (TO to) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN binding))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (NN _PROT_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT2_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT2_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NN _PROT_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD employed) (NP (ADJP (CC both) (ADJP (JJ random)) (CC and) (ADJP (JJ site-specific))) (NN mutagenesis)) (S (VP (TO to) (VP (VB determine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN amino) (NN acid) (NNS residues)) (PP (IN in) (NP (NP (NP (DT the) (JJ extracellular) (NN domain)) (PRN (-LRB- -LRB-) (VP (VBN referred) (PP (TO to)) (PP (IN as) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (NN _PROT1_))))) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Site-specific) (NNS mutants)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN in) (NP (FW Escherichia) (FW coli))) (PP (IN as) (NP (JJ soluble) (NN _PROT1_)))) (CC and) (VP (VBN analyzed) (PP (IN for) (NP (NN _PROT2_) (NN binding))) (PP (IN in) (NP (JJ several) (JJ different) (NN assay) (NNS formats))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (VBN selected) (JJ mutant) (NNS proteins)) (VP (VBD were) (VP (VP (VBN expressed) (PP (IN as) (NP (JJ full-length) (NN _PROT1_))) (PP (IN on) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN COS) (NNS cells)))))) (CC and) (VP (VBN analyzed) (PP (IN for) (NP (NN _PROT2_) (NN binding))) (PP (IN in) (NP (NN receptor) (NN binding) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT these) (NNS methods)))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (NNS residues)) (SBAR (WHNP (WDT that)) (S (VP (VBP appear) (S (VP (TO to) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (NN _PROT1_) (NN binding)) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ other) (NNS residues)) (, ,) (SBAR (WHNP (NP (JJS most)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBP are) (VP (VBN conserved) (PP (IN in) (NP (NP (NNS receptors)) (PP (IN of) (NP (NP (DT the) (NN cytokine) (NN receptor) (NN family)) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBP appear) (S (VP (TO to) (VP (VB be) (ADJP (JJ necessary) (PP (IN for) (NP (NP (NP (DT the) (JJ proper) (NN folding)) (CC and/or) (NP (NN stability))) (PP (IN of) (NP (DT the) (NN _PROT2_)))))))))))))))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN _PROT1_) (NN _PROT_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT an) (JJ important) (NN mediator)) (PP (IN of) (NP (JJ inflammatory) (NN disease)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN family)) (ADVP (RB currently)) (VP (VBZ consists) (PP (IN of) (NP (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,)) (CC and) (NP (NP (CD one) (NN antagonist)) (, ,) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Each)) (PP (IN of) (NP (DT these) (NNS molecules)))) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Each)) (PP (IN of) (NP (DT these) (NNS molecules)))) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Each)) (PP (IN of) (NP (DT these) (NNS molecules)))) (VP (VBZ binds) (PP (TO to) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT2_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT2_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (TO to) (NP (NN _PROT_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT2_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN binding)) (PP (IN of) (NP (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBZ is) (NP (NP (DT an) (JJ early) (NN step)) (PP (IN in) (NP (NN _PROT2_) (NN signal) (NN transduction))))) (CC and) (VP (VBG blocking) (S (NP (DT this) (NN interaction)) (VP (MD may) (ADVP (RB therefore)) (VP (VB be) (NP (NP (DT a) (JJ useful) (NN target)) (PP (IN for) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (JJ new) (NNS drugs)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (PP (IN at) (NP (CD 2.5) (NN A) (NN resolution)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (PP (IN at) (NP (CD 2.5) (NN A) (NN resolution)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (DT the) (JJ extracellular) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (PP (IN at) (NP (CD 2.5) (NN A) (NN resolution)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NN _PROT2_))) (PP (IN with) (NP (DT a) (JJ 1:1) (NN stoichiometry))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN crystal) (NN structure)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ consists) (PP (IN of) (NP (NP (CD three) (JJ immunoglobulin-like) (NNS domains)) (SBAR (WHNP (WDT which)) (S (VP (VB wrap) (PP (IN around) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN manner)) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT the) (NNS structures)) (PP (IN of) (NP (ADJP (RB previously) (VBN described)) (JJ cytokine-receptor) (NNS complexes)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (JJ previous) (NN work)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD might) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (JJ _PROT_) (NN repression)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (JJ previous) (NN work)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (MD might) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (JJ _PROT2_) (NN repression)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (JJ previous) (NN work)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (MD might) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (JJ _PROT2_) (NN repression)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT2_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT2_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (DT the) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (NN _PROT1_)))) (, ,)))) (VP (VBZ is) (RB not) (ADJP (JJ sufficient) (PP (IN for) (NP (NP (NN repression)) (PP (IN of) (NP (JJ _PROT2_) (NN transcription))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Repression)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription)))) (VP (MD may) (VP (VB be) (VP (VBN accomplished) (PP (IN through) (NP (NP (JJ direct) (JJ physical) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (DT this) (NN activator)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ physical) (NN interaction)) (VP (VBZ is) (RB not) (ADJP (JJ necessary) (PP (IN for) (NP (NN _PROT1_)))) (S (VP (TO to) (VP (VB repress) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (NN transcription)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ physical) (NN interaction)) (VP (VBZ is) (RB not) (ADJP (JJ necessary) (PP (IN for) (NP (NN _PROT1_)))) (S (VP (TO to) (VP (VB repress) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (NN transcription)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (JJ physical) (NN interaction)) (VP (VBZ is) (RB not) (ADJP (JJ necessary) (PP (IN for) (NP (NN _PROT_)))) (S (VP (TO to) (VP (VB repress) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NN transcription)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NN cell) (NN migration))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN cleavage)) (PP (IN of) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Specific) (NN cleavage)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB induce) (NP (NP (NN migration)) (PP (IN of) (NP (NN breast) (JJ epithelial) (NNS cells)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT1_) (NN _PROT_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBN cleaved) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN subunit)) (PP (IN at) (NP (NN residue) (CD 587))) (, ,) (S (VP (VBG exposing) (NP (NP (DT a) (JJ putative) (JJ cryptic) (JJ promigratory) (NN site)) (PP (IN on) (NP (NN _PROT2_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ triggers) (NP (NN cell) (NN motility)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN Cleavage)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT2_)))) (CC and) (NP (NP (DT the) (VBG resulting) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_) (JJ cryptic) (NN site))))) (VP (MD may) (VP (VB provide) (NP (NP (JJ new) (NNS targets)) (PP (IN for) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NN tumor) (NN cell) (NN invasion)) (CC and) (NP (NN tissue) (NN remodeling)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Cleavage)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT_)))) (CC and) (NP (NP (DT the) (VBG resulting) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (JJ cryptic) (NN site))))) (VP (MD may) (VP (VB provide) (NP (NP (JJ new) (NNS targets)) (PP (IN for) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NN tumor) (NN cell) (NN invasion)) (CC and) (NP (NN tissue) (NN remodeling)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Cleavage)) (PP (IN of) (NP (NN _PROT_))) (PP (IN by) (NP (NN _PROT1_)))) (CC and) (NP (NP (DT the) (VBG resulting) (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_) (JJ cryptic) (NN site))))) (VP (MD may) (VP (VB provide) (NP (NP (JJ new) (NNS targets)) (PP (IN for) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NN tumor) (NN cell) (NN invasion)) (CC and) (NP (NN tissue) (NN remodeling)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_AND_PROT2_) (NN complex)) (: :) (NP (NP (NP (JJ structural) (NN basis)) (PP (IN for) (NP (NN GTPase) (NN activation)))) (CC and) (NP (NP (PRP$ its) (NN loss)) (PP (IN in) (NP (JJ oncogenic) (NN _PROT_) (NNS mutants)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (: :) (NP (NP (NP (JJ structural) (NN basis)) (PP (IN for) (NP (NN GTPase) (NN activation)))) (CC and) (NP (NP (PRP$ its) (NN loss)) (PP (IN in) (NP (JJ oncogenic) (NN _PROT2_) (NNS mutants)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN complex)) (: :) (NP (NP (NP (JJ structural) (NN basis)) (PP (IN for) (NP (NN GTPase) (NN activation)))) (CC and) (NP (NP (PRP$ its) (NN loss)) (PP (IN in) (NP (JJ oncogenic) (NN _PROT2_) (NNS mutants)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT2_) (NN _PROT2_)) (NP (NN _PROT_) (-LRB- -LRB-) (CD _PROT_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT2_) (-LRB- -LRB-) (CD _PROT_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT1_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_) (-LRB- -LRB-) (CD _PROT_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ three-dimensional) (NN structure)) (PP (IN of) (NP (NP (DT the) (NN complex)) (PP (IN between) (NP (NP (JJ human) (NN _PROT_)) (VP (VBD bound) (PP (TO to) (NP (NP (NN guanosine) (NN diphosphate)) (CC and) (NP (NP (DT the) (NP (NP (NN guanosine) (NN triphosphatase)) (PRN (-LRB- -LRB-) (NP (NN GTPase)) (-RRB- -RRB-))) (NN -activating) (NN domain)) (PP (IN of) (NP (NP (NP (DT the) (JJ human) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT1_) (-LRB- -LRB-) (CD _PROT2_) (-RRB- -RRB-))) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN aluminum) (NN fluoride)))))))))))))))) (VP (VBD was) (VP (VBN solved) (PP (IN at) (NP (NP (DT a) (NN resolution)) (PP (IN of) (NP (CD 2.5) (NN angstroms)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT An) (NN arginine) (JJ side) (NN chain)) (PRN (-LRB- -LRB-) (NP (NN arginine-789)) (-RRB- -RRB-))) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN supplied) (PP (IN into) (NP (NP (DT the) (JJ active) (NN site)) (PP (IN of) (NP (NN _PROT2_))))) (S (VP (TO to) (VP (VBP neutralize) (NP (NP (VBG developing) (NNS charges)) (PP (IN in) (NP (DT the) (NN transition) (NN state)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN switch) (NN II) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN stabilized) (PP (IN by) (NP (NN _PROT2_)))) (, ,) (S (ADVP (RB thus)) (VP (VBG allowing) (NP (NP (NN glutamine-61)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (SBAR (WHNP (NP (NN mutation)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBZ activates) (NP (DT the) (JJ oncogenic) (NN potential))))) (, ,)))) (S (VP (TO to) (VP (VB participate) (PP (IN in) (NP (NN catalysis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN switch) (NN II) (NN region)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN stabilized) (PP (IN by) (NP (NN _PROT_)))) (, ,) (S (ADVP (RB thus)) (VP (VBG allowing) (NP (NP (NN glutamine-61)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (NP (NN mutation)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBZ activates) (NP (DT the) (JJ oncogenic) (NN potential))))) (, ,)))) (S (VP (TO to) (VP (VB participate) (PP (IN in) (NP (NN catalysis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN switch) (NN II) (NN region)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN stabilized) (PP (IN by) (NP (NN _PROT1_)))) (, ,) (S (ADVP (RB thus)) (VP (VBG allowing) (NP (NP (NN glutamine-61)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (SBAR (WHNP (NP (NN mutation)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBZ activates) (NP (DT the) (JJ oncogenic) (NN potential))))) (, ,)))) (S (VP (TO to) (VP (VB participate) (PP (IN in) (NP (NN catalysis)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Glycine-12)) (PP (IN in) (NP (NP (DT the) (NN transition) (NN state)) (VP (VB mimic))))) (VP (VBZ is) (PP (IN within) (NP (NP (NN van) (NN der) (NN Waals) (NN distance)) (PP (IN of) (NP (CC both) (NP (NP (CD arginine-789)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (CD glutamine-61)) (PP (IN of) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (RB even) (S (NP (NP (PRP$ its) (NN mutation)) (PP (TO to) (NP (NN alanine)))) (VP (MD would) (VP (VBP disturb) (NP (NP (DT the) (NNS arrangements)) (PP (IN of) (NP (NP (NNS residues)) (PP (IN in) (NP (DT the) (NN transition) (NN state))))))))) (. .))) |ET|
