-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NP (NN glucocorticoid) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NNS GRs)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN in) (NP (NP (DT the) (JJ nasal) (NNS polyps)) (PP (IN of) (NP (JJ nonallergic) (NNS patients)))))) (SBAR (IN as) (S (VP (VBN compared) (PP (IN with) (NP (JJ normal) (NNS controls)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN contrast))) (, ,) (S (PP (IN in) (NP (JJ normal) (JJ nasal) (NNS tissues))) (, ,) (NP (NN _PROT1_) (NN labeling)) (VP (VBD was) (ADVP (RB only)) (VP (VBN found) (PP (IN in) (NP (DT the) (JJ vascular) (NN wall)))))) (, ,) (CC and) (S (NP (DT the) (NN expression)) (VP (VBD was) (NP (JJ weaker--a) (NN finding)) (S (VP (VBG demonstrating) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN in) (NP (JJ nasal) (NNS polyps)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Therefore)) (, ,) (NP (LST (LS 1) (-RRB- -RRB-)) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NNS GRs)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (JJ nasal) (NNS polyps)) (PP (IN from) (NP (JJ nonallergic) (NNS patients)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN upregulation)) (PP (IN of) (NP (NN _PROT2_) (NN expression)))) (, ,)) (VP (VBZ suggests) (SBAR (IN that) (S (S (NP (NN inflammation)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (DT the) (NN pathophysiology)) (PP (IN of) (NP (JJ nasal) (NNS polyps)))))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN glucocorticoid)) (VP (MD could) (VP (VB be) (NP (NP (DT a) (JJ potential) (NN treatment) (NN method)) (PP (IN for) (S (VP (VBG suppressing) (NP (JJ inflammatory) (NNS processes)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN superfamily)))) (, ,)) (VP (VBZ has) (NP (JJ various) (NNS effects)) (PP (IN on) (NP (NP (JJ diverse) (JJ biological) (NNS systems)) (, ,) (PP (VBG including) (NP (NP (NN cell) (NN growth) (NN inhibition)) (PP (IN in) (NP (JJ many) (NN cell) (NNS types))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBN Based) (PP (IN on) (NP (NP (DT the) (NNS experiences)) (PP (IN of) (NP (PDT all) (DT the) (NNS authors)))))) (, ,) (NP (PRP we)) (VP (VBD emphasized) (NP (NP (NP (NN cell) (NN cycle) (NNS inhibitors)) (PP (JJ such) (IN as) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (NNS regulators)) (PP (IN of) (NP (NN apoptosis))) (PP (JJ such) (IN as) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Native) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD formed) (NP (NP (DT a) (NN heterodimer)) (PP (IN in) (NP (NN solution))) (PP (IN of) (NP (JJ physiological) (JJ ionic) (NN strength)))) (PP (IN with) (NP (NP (NP (DT a) (JJ free-energy) (NN change) (NN DeltaG) (NNS degrees)) (PP (IN of) (NP (CD -8.3) (NN kcal/mol)))) (CC and) (NP (NP (NP (DT a) (NN dissociation) (NN constant)) (NN Kd)) (PP (IN of) (NP (NP (NP (CD 0.6) (NN microM)) (PRN (-LRB- -LRB-) (PP (IN at) (NP (CD 20) (NNS degrees) (NN C))) (-RRB- -RRB-))) (SBAR (WHNP (WDT that)) (S (VP (VBD was) (NP (NP (JJ ionic) (NN strength-)) (CC and) (NP (NN temperature-dependent)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ va) (ADJP (RB n't) (JJ Hoff)) (NN plot)) (PP (IN of) (NP (NP (DT the) (NN change)) (PP (IN in) (NP (NN Kd)))))) (VP (VP (VBD was) (ADJP (JJ linear) (PP (IN between) (NP (CD 10) (CC and) (CD 37) (NNS degrees) (NN C))))) (CC and) (VP (VBD yielded) (NP (NP (NNS values)) (PP (IN of) (NP (NP (NP (NP (JJ DeltaH) (NNS degrees)) (VP (VBG =) (NP (CD -12.9) (NN kcal/mol)))) (CC and) (NP (NN DeltaS) (NNS degrees))) (VP (JJ =) (NP (CD -15.9) (JJ cal) (NN mol-1) (NN deg-1))))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (JJ electrostatic) (NNS forces)) (VP (VBP play) (NP (DT a) (JJ prominent) (NN role)) (PP (IN in) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (JJ Native) (NN _PROT1_)) (ADVP (RB also)) (VP (VBD formed) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NN _PROT2_)))))) (, ,) (CC and) (S (NP (NP (JJ low) (NNS concentrations)) (PP (IN of) (NP (NP (JJ polyionic) (NNS ligands)) (PP (JJ such) (IN as) (NP (NP (NN protamine)) (CC and) (NP (NN suramin))))))) (VP (VBD inhibited) (NP (DT the) (NN interaction))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Suramin)) (VP (VBD induced) (NP (NP (JJ high-affinity) (NN trimerization)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 0.10) (NN microM)) (PP (IN at) (NP (CD 20) (NNS degrees) (NN C))) (-RRB- -RRB-))) (CC and) (NP (NP (NN dimerization) (IN of) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 0.86) (NN microM)) (PP (IN at) (NP (CD 20) (NNS degrees) (NN C))) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Analysis)) (PP (PP (IN of) (NP (NN sedimentation) (NNS equilibria))) (CC and) (ADVP (RB also)) (PP (IN of) (NP (NP (DT the) (NN fluorescence) (NN enhancement)) (PP (IN of) (NP (NN suramin)))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN bound) (PP (TO to) (NP (NN protein))))))) (VP (VBD provided) (NP (NP (NN evidence)) (PP (IN for) (NP (NP (CD two) (JJ suramin-binding) (NNS sites)) (PP (IN on) (NP (NP (DT each) (NP (NN _PROT1_)) (CC and) (NP (CD three))) (PP (IN on) (NP (DT each) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NNS oligomers))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN ectodomain) (NN complex))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Bone) (NN morphogenetic) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN BMPs)) (-RRB- -RRB-))) (VP (VBP belong) (PP (TO to) (NP (NP (DT the) (JJ large) (NP (NP (VBG _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN superfamily)) (PP (IN of) (NP (JJ multifunctional) (NNS cytokines))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT1_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (JJ _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT1_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT1_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT_) (NN _PROT_) (NN _PROT_) (JJ _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (JJ _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ _PROT_) (NNS _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (JJ human) (JJ dimeric) (NN _PROT_))) (PP (IN in) (NP (NP (NN complex)) (PP (IN with) (NP (NP (CD two) (JJ high) (NN affinity) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNS _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN receptor) (NNS chains)) (VP (VBP bind) (PP (TO to) (NP (NP (DT the) (`` ') (NN wrist) (POS ') (NNS epitopes)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN dimer) (CC and) (NN contact) (CC both) (NN _PROT2_) (NNS monomers))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN ectodomain))) (PP (IN in) (NP (NP (DT a) (JJ dimeric) (NN form)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN induced) (PP (IN by) (NP (NP (JJ simultaneous) (NN binding)) (PP (TO to) (NP (NP (NN _PROT2_)) (CC and) (NP (DT a) (NN heparin)) (NP (NN decasaccharide))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN structure)) (PP (IN of) (NP (DT the) (JJ _PROT1_AND_PROT2_) (JJ ternary) (NN complex)))) (VP (VBZ provides) (NP (NP (DT a) (JJ structural) (NN basis)) (PP (IN for) (NP (NP (DT the) (JJ essential) (NN role)) (PP (IN of) (NP (NN heparan) (NN sulphate))) (PP (IN in) (NP (NN FGF) (NN signalling)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Kaposi) (POS 's) (JJ sarcoma-associated) (NN herpesvirus)) (VP (VBZ encodes) (NP (NP (DT a) (JJ functional) (NN homolog)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Kaposi) (POS 's) (JJ sarcoma-associated) (NN herpesvirus)) (VP (VBZ encodes) (NP (NP (DT a) (JJ functional) (NN homolog)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Kaposi) (POS 's) (JJ sarcoma-associated) (NN herpesvirus)) (VP (VBZ encodes) (NP (NP (DT a) (JJ functional) (NN homolog)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT1_)) (CC and) (NP (JJ human) (NN _PROT2_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT1_)) (CC and) (NP (JJ human) (NN _PROT_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT1_)) (CC and) (NP (JJ human) (NN _PROT_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT_)) (CC and) (NP (JJ human) (NN _PROT1_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT_)) (CC and) (NP (JJ human) (NN _PROT1_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (CD 2.4) (NN angstrom) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ extracellular) (VBG signaling) (NN assembly)) (PP (IN between) (NP (NP (JJ viral) (NN _PROT_)) (CC and) (NP (JJ human) (NN _PROT_)))))))) (, ,) (NP (CD two) (NNS complexes)) (VP (VBP are) (VP (VBN cross-linked) (PP (IN into) (NP (NP (DT a) (NN tetramer)) (PP (IN through) (NP (NP (JJ direct) (NNS interactions)) (PP (IN between) (NP (NP (NP (DT the) (NN immunoglobulin) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (NN site) (CD III)) (PP (IN of) (NP (NP (JJ viral) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ necessary) (PP (IN for) (NP (NN receptor) (NN activation)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT1_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT1_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Unlike) (NP (NP (JJ human) (NN _PROT_)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ uses) (NP (JJ many) (JJ hydrophilic) (NNS residues))))) (-RRB- -RRB-))) (, ,) (NP (DT the) (JJ viral) (NN cytokine)) (ADVP (RB largely)) (VP (VBZ uses) (NP (JJ hydrophobic) (NN amino) (NNS acids)) (PP (TO to) (NP (NP (NN contact) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ enhances) (NP (NP (DT the) (NN complementarity)) (PP (IN of) (NP (DT the) (JJ viral) (NN _PROT1_AND_PROT2_) (NN binding) (NNS interfaces))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN cross-reactivity)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (RB apparently) (JJ due) (PP (TO to) (NP (NP (DT a) (JJ chemical) (NN plasticity)) (ADJP (JJ evident) (PP (IN in) (NP (DT the) (JJ amphipathic) (NN _PROT2_) (JJ cytokine-binding) (NNS sites))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Analysis)) (PP (IN of) (NP (NP (DT the) (NN oligomerization)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS products)) (ADJP (FW in) (FW vivo))))))) (VP (VBG using) (NP (DT a) (JJ two-hybrid) (NN assay) (NN system))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT2_) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT_) (NN gene) (NNS products)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT_) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT1_) (NN gene) (NNS products)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT1_) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ muscle-specific) (JJ HLH) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NN DNA)) (ADVP (FW in) (FW vitro)) (PP (IN as) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (JJ several) (ADJP (RB widely) (VBN expressed)) (JJ HLH) (NNS proteins)) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (NN _PROT_) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (S (NP (NN _PROT1_)) (VP (VBZ heterodimerizes) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))) (ADVP (FW in) (FW vivo)))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ does) (RB not) (VP (VB homodimerize) (PP (TO to) (NP (DT a) (JJ measurable) (NN extent)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (S (NP (NN _PROT1_)) (VP (VBZ heterodimerizes) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ does) (RB not) (VP (VB homodimerize) (PP (TO to) (NP (DT a) (JJ measurable) (NN extent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (S (NP (NN _PROT_)) (VP (VBZ heterodimerizes) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (ADVP (FW in) (FW vivo)))) (, ,) (CC but) (S (NP (PRP it)) (VP (VBZ does) (RB not) (VP (VB homodimerize) (PP (TO to) (NP (DT a) (JJ measurable) (NN extent)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT2_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT2_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN growth) (NNS factors)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (JJ immediate) (JJ early) (NN gene) (NNS products)) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))) (, ,)) (VP (VBP inhibit) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NN myogenin)))) (PP (IN through) (NP (NP (DT a) (NN mechanism)) (ADJP (JJ independent) (PP (IN of) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NN _PROT2_) (NNS products)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ extracellular) (JJ cysteine-rich) (NN domain)) (PP (IN of) (NP (DT the) (NN TNF-R)))) (VP (VBZ is) (ADJP (JJ homologous) (PP (TO to) (NP (NP (DT the) (NP (NN nerve) (NN growth) (NN factor)) (NN receptor)) (CC and) (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Unlabeled) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADJP (RB equally) (JJ effective) (PP (IN at) (S (VP (VBG displacing) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (JJ labeled) (NN _PROT_))) (PP (TO to) (NP (NN TNF-R) (NN expressing) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Unlabeled) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (ADJP (RB equally) (JJ effective) (PP (IN at) (S (VP (VBG displacing) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (JJ labeled) (NN _PROT2_))) (PP (TO to) (NP (NN TNF-R) (NN expressing) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Unlabeled) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (ADJP (RB equally) (JJ effective) (PP (IN at) (S (VP (VBG displacing) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (JJ labeled) (NN _PROT2_))) (PP (TO to) (NP (NN TNF-R) (NN expressing) (NNS cells)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN Identification)) (PP (IN of) (NP (NP (DT an) (JJ 11-kDa) (JJ _PROT1_) (NN domain)) (PP (IN within) (NP (DT the) (JJ 289-kDa) (JJ _PROT2_) (NN _PROT2_)))))) (CC and) (NP (NP (NN characterization)) (PP (IN of) (NP (DT a) (JJ critical) (NN serine) (NN residue))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (S (ADVP (RB Previously)) (, ,) (NP (NP (DT a) (JJ mammalian) (NN protein)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT1_))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN identified))))) (CC and) (NP (PRP$ its) (VBG encoding) (NN gene)) (VP (VBZ has) (VP (VBN been) (VP (VBN cloned) (PP (IN from) (NP (DT both) (JJ human) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT2_)) (-RRB- -RRB-)) (NN [Brown))) (PRN (, ,) (NP (NP (NNP E.J.) (, ,) (NNP Albers) (, ,) (NN M.W.) (, ,) (NP (NNP Shin) (, ,) (NNP T.B.) (, ,) (NNP Ichikawa) (, ,) (NNP K.) (, ,) (NNP Keith) (, ,) (NNP C.T.) (, ,) (NNP Lane) (, ,) (NNP W.S.) (NNP &) (NNP Schreiber) (, ,) (NNP S.L.))) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Nature) (-LRB- -LRB-) (NNP London) (-RRB- -RRB-) (: 369)) (, ,) (NP (CD 756-758) (-RRB- -RSB-) (CC and) (NN rat) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT_)) (-RRB- -RRB-)) (NNS [Sabatini)) (, ,) (NP (NNP D.M.) (, ,) (NN Erdjument-Bromage) (, ,) (NNP H.) (, ,) (NNP Lui) (, ,) (NNP M.) (, ,) (NNP Tempst) (, ,) (NNP P.) (NNP &) (NNP Snyder) (, ,) (NNP S.H.)) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Cell) (CD 78)) (, ,) (NP (NN 35-43))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Previously)) (, ,) (NP (NP (DT a) (JJ mammalian) (NN protein)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT1_))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN identified))))) (CC and) (NP (PRP$ its) (VBG encoding) (NN gene)) (VP (VBZ has) (VP (VBN been) (VP (VBN cloned) (PP (IN from) (NP (DT both) (JJ human) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT_)) (-RRB- -RRB-)) (NN [Brown))) (PRN (, ,) (NP (NP (NNP E.J.) (, ,) (NNP Albers) (, ,) (NN M.W.) (, ,) (NP (NNP Shin) (, ,) (NNP T.B.) (, ,) (NNP Ichikawa) (, ,) (NNP K.) (, ,) (NNP Keith) (, ,) (NNP C.T.) (, ,) (NNP Lane) (, ,) (NNP W.S.) (NNP &) (NNP Schreiber) (, ,) (NNP S.L.))) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Nature) (-LRB- -LRB-) (NNP London) (-RRB- -RRB-) (: 369)) (, ,) (NP (CD 756-758) (-RRB- -RSB-) (CC and) (NN rat) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT2_)) (-RRB- -RRB-)) (NNS [Sabatini)) (, ,) (NP (NNP D.M.) (, ,) (NN Erdjument-Bromage) (, ,) (NNP H.) (, ,) (NNP Lui) (, ,) (NNP M.) (, ,) (NNP Tempst) (, ,) (NNP P.) (NNP &) (NNP Snyder) (, ,) (NNP S.H.)) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Cell) (CD 78)) (, ,) (NP (NN 35-43))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Previously)) (, ,) (NP (NP (DT a) (JJ mammalian) (NN protein)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT_))))))) (VP (VBZ has) (VP (VBN been) (VP (VBN identified))))) (CC and) (NP (PRP$ its) (VBG encoding) (NN gene)) (VP (VBZ has) (VP (VBN been) (VP (VBN cloned) (PP (IN from) (NP (DT both) (JJ human) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT1_)) (-RRB- -RRB-)) (NN [Brown))) (PRN (, ,) (NP (NP (NNP E.J.) (, ,) (NNP Albers) (, ,) (NN M.W.) (, ,) (NP (NNP Shin) (, ,) (NNP T.B.) (, ,) (NNP Ichikawa) (, ,) (NNP K.) (, ,) (NNP Keith) (, ,) (NNP C.T.) (, ,) (NNP Lane) (, ,) (NNP W.S.) (NNP &) (NNP Schreiber) (, ,) (NNP S.L.))) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Nature) (-LRB- -LRB-) (NNP London) (-RRB- -RRB-) (: 369)) (, ,) (NP (CD 756-758) (-RRB- -RSB-) (CC and) (NN rat) (PRN (-LRB- -LRB-) (NP (VBN designated) (NN _PROT2_)) (-RRB- -RRB-)) (NNS [Sabatini)) (, ,) (NP (NNP D.M.) (, ,) (NN Erdjument-Bromage) (, ,) (NNP H.) (, ,) (NNP Lui) (, ,) (NNP M.) (, ,) (NNP Tempst) (, ,) (NNP P.) (NNP &) (NNP Snyder) (, ,) (NNP S.H.)) (-LRB- -LRB-) (NP (CD 1994)) (-RRB- -RRB-) (NP (NNP Cell) (CD 78)) (, ,) (NP (NN 35-43))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (NP (DT an) (ADJP (FW in) (FW vitro)) (NN transcription/translation) (NN assay) (NN method)) (VP (VBN coupled) (PP (IN with) (NP (NN proteolysis) (NNS studies))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT an) (JJ 11-kDa) (JJ _PROT1_) (NN domain)) (PP (IN within) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT_)) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (NP (NN _PROT_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_AND_PROT2_) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT_)) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene) (NN product)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT the) (NN protein) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN tumor-suppressor) (NN gene)))) (, ,)) (VP (VBZ regulates) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (JJ specific) (NN transcription) (NNS factors)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP report) (SBAR (IN that) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription))) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (ADVP (RB partially)) (VP (VBN abrogated) (PP (IN at) (NP (NP (DT the) (JJ nonpermissive) (NN temperature)) (PP (IN in) (NP (NN ts13) (NNS cells))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NN _PROT_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT_)) (NP (NN _PROT2_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT_)) (NP (NN _PROT_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT2_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (NP (NN _PROT_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS cells)) (VP (VBP contain) (NP (NP (DT a) (JJ temperature-sensitive) (NN mutation)) (PP (IN in) (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (NP (NN _PROT1_)))) (, ,) (VP (ADVP (RB first)) (VBN identified) (PP (IN as) (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN stimulation)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription))) (PP (IN by) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN ts13) (NNS cells)) (PP (IN at) (NP (DT the) (JJ nonpermissive) (NN temperature)))))) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN introduction)) (PP (IN of) (NP (JJ wild-type) (JJ human) (NN _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN stimulation)) (PP (IN of) (NP (JJ _PROT1_) (NN transcription))) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN ts13) (NNS cells)) (PP (IN at) (NP (DT the) (JJ nonpermissive) (NN temperature)))))) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN introduction)) (PP (IN of) (NP (JJ wild-type) (JJ human) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN stimulation)) (PP (IN of) (NP (JJ _PROT_) (NN transcription))) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN ts13) (NNS cells)) (PP (IN at) (NP (DT the) (JJ nonpermissive) (NN temperature)))))) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN introduction)) (PP (IN of) (NP (JJ wild-type) (JJ human) (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB directly)) (PP (TO to) (NP (CD _PROT2_))) (ADVP (ADVP (FW in) (FW vitro)) (CC and) (ADVP (FW in) (FW vivo)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB confer) (NP (NP (JJ transcriptional) (NN regulation)) (CC and) (ADVP (RB possibly)) (NP (NN cell) (NN cycle) (NN control)) (CC and) (NP (NN tumor) (NN suppression))) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))) (, ,) (PP (IN in) (NP (NP (JJ particular)) (PP (IN with) (NP (NN _PROT_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD can) (VP (VB confer) (NP (NP (JJ transcriptional) (NN regulation)) (CC and) (ADVP (RB possibly)) (NP (NN cell) (NN cycle) (NN control)) (CC and) (NP (NN tumor) (NN suppression))) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT_))))) (, ,) (PP (IN in) (NP (NP (JJ particular)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD can) (VP (VB confer) (NP (NP (JJ transcriptional) (NN regulation)) (CC and) (ADVP (RB possibly)) (NP (NN cell) (NN cycle) (NN control)) (CC and) (NP (NN tumor) (NN suppression))) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (NN _PROT1_))))) (, ,) (PP (IN in) (NP (NP (JJ particular)) (PP (IN with) (NP (NN _PROT2_))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN inhibitor)) (PP (IN of) (NP (JJ cyclin-dependent) (NNS kinases)))) (VP (VBZ controls) (NP (NN DNA) (NN replication)) (PP (IN by) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN tumour-suppressor) (NN protein)) (VP (VBZ controls) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN gene)) (VP (VBG encoding) (NP (DT the) (NP (NP (NN _PROT2_) (JJ cyclin-dependent) (NN protein) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN CDK)) (-RRB- -RRB-))) (NN regulator)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Levels)) (PP (IN of) (NP (NN _PROT1_) (NN protein)))) (VP (VBP are) (VP (VBN increased) (PP (IN in) (NP (JJ senescent) (NNS cells)))))) (CC and) (S (NP (NN _PROT2_) (NN overexpression)) (VP (VBZ blocks) (NP (NP (DT the) (NN growth)) (PP (IN of) (NP (NN tumour) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (PP (IN In) (NP (JJ normal) (JJ human) (NNS cells))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ many) (NN tumour) (NNS cells)))) (, ,) (NP (NN _PROT1_)) (VP (VBZ exists) (PP (IN in) (NP (NP (DT a) (JJ quaternary) (NN complex)) (PP (IN with) (NP (NP (DT a) (NN cyclin)) (, ,) (NP (DT a) (NN CDK)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (PP (IN In) (NP (JJ normal) (JJ human) (NNS cells))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ many) (NN tumour) (NNS cells)))) (, ,) (NP (NN _PROT1_)) (VP (VBZ exists) (PP (IN in) (NP (NP (DT a) (JJ quaternary) (NN complex)) (PP (IN with) (NP (NP (DT a) (NN cyclin)) (, ,) (NP (DT a) (NN CDK)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (PP (IN In) (NP (JJ normal) (JJ human) (NNS cells))) (, ,) (CC but) (PP (RB not) (IN in) (NP (JJ many) (NN tumour) (NNS cells)))) (, ,) (NP (NN _PROT_)) (VP (VBZ exists) (PP (IN in) (NP (NP (DT a) (JJ quaternary) (NN complex)) (PP (IN with) (NP (NP (DT a) (NN cyclin)) (, ,) (NP (DT a) (NN CDK)) (, ,) (CC and) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ controls) (NP (NN CDK) (NN activity)) (, ,) (S (ADVP (RB thereby)) (VP (VBG affecting) (NP (JJ cell-cycle) (NN control)))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VBZ functions) (PP (IN in) (NP (CC both) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP use) (NP (NP (JJ simian) (NN virus) (CD 40)) (NN DNA) (NN replication)) (ADVP (FW in) (FW vitro)) (S (VP (TO to) (VP (VB show) (SBAR (IN than) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ inhibits) (NP (JJ _PROT2_) (NN DNA) (NN replication)) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (NN a) (CD cyclin/CDK)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT1_)) (VP (VBZ blocks) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (, ,) (NP (DT the) (JJ principal) (JJ replicative) (NN DNA) (NN polymerase))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT1_)) (VP (VBZ blocks) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT the) (JJ principal) (JJ replicative) (NN DNA) (NN polymerase))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT_)) (VP (VBZ blocks) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT the) (JJ principal) (JJ replicative) (NN DNA) (NN polymerase))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This) (NN regulation)) (VP (VBZ results) (PP (IN from) (NP (NP (DT a) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (NP (JJ _PROT1_) (NN suppression)) (PP (IN of) (NP (NN cell) (NN proliferation))))) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN for) (S (VP (VBG coordinating) (NP (NP (NP (JJ cell-cycle) (NN progression)) (, ,) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))) (PP (IN of) (NP (JJ damaged) (NN DNA))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (NP (JJ _PROT1_) (NN suppression)) (PP (IN of) (NP (NN cell) (NN proliferation))))) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN for) (S (VP (VBG coordinating) (NP (NP (NP (JJ cell-cycle) (NN progression)) (, ,) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))) (PP (IN of) (NP (JJ damaged) (NN DNA))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (PP (IN during) (NP (NP (JJ _PROT_) (NN suppression)) (PP (IN of) (NP (NN cell) (NN proliferation))))) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN for) (S (VP (VBG coordinating) (NP (NP (NP (JJ cell-cycle) (NN progression)) (, ,) (NP (NN DNA) (NN replication)) (CC and) (NP (NN repair))) (PP (IN of) (NP (JJ damaged) (NN DNA))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Nuclear) (NN protein) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN coactivator)) (PP (IN for) (NP (DT the) (NN transcription) (NN factor) (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT_)) (VP (VBZ is) (VP (VBN activated) (PP (IN through) (NP (NN phosphorylation))) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))))) (, ,) (CC but) (S (ADVP (RB precisely)) (SBAR (WHADVP (WRB how)) (S (NP (NN phosphorylation)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN function))))) (VP (VBZ is) (ADJP (JJ unknown))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN of) (NP (NN M) (-LRB- -LRB-) (NN r) (-RRB- -RRB-) (CD 265K)))) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT the) (JJ _PROT2_) (NN form)) (PP (IN of) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN of) (NP (NN M) (-LRB- -LRB-) (NN r) (-RRB- -RRB-) (CD 265K)))) (, ,) (NP (NN _PROT1_)) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT the) (JJ _PROT_) (NN form)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN identified) (NP (NP (NP (NP (DT a) (JJ nuclear) (NN protein)) (PP (IN of) (NP (NN M) (-LRB- -LRB-) (NN r) (-RRB- -RRB-) (CD 265K)))) (, ,) (NP (NN _PROT_)) (, ,)) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT the) (JJ _PROT1_) (NN form)) (PP (IN of) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NN fluorescence) (NN anisotropy) (NNS measurements)) (S (VP (VP (TO to) (VP (VB define) (NP (NP (DT the) (NN equilibrium) (NN binding) (NNS parameters)) (PP (IN of) (NP (DT the) (NN _PROT1_) (: :) (NN _PROT2_) (NN interaction)))))) (CC and) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD can) (VP (VB activate) (NP (NN transcription)) (PP (IN through) (NP (NP (DT a) (NN region)) (PP (IN in) (NP (PRP$ its) (NN carboxy) (NN terminus))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NN fluorescence) (NN anisotropy) (NNS measurements)) (S (VP (VP (TO to) (VP (VB define) (NP (NP (DT the) (NN equilibrium) (NN binding) (NNS parameters)) (PP (IN of) (NP (DT the) (NN _PROT1_) (: :) (NN _PROT_) (NN interaction)))))) (CC and) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD can) (VP (VB activate) (NP (NN transcription)) (PP (IN through) (NP (NP (DT a) (NN region)) (PP (IN in) (NP (PRP$ its) (NN carboxy) (NN terminus))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN used) (NP (NN fluorescence) (NN anisotropy) (NNS measurements)) (S (VP (VP (TO to) (VP (VB define) (NP (NP (DT the) (NN equilibrium) (NN binding) (NNS parameters)) (PP (IN of) (NP (DT the) (NN _PROT_) (: :) (NN _PROT1_) (NN interaction)))))) (CC and) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD can) (VP (VB activate) (NP (NN transcription)) (PP (IN through) (NP (NP (DT a) (NN region)) (PP (IN in) (NP (PRP$ its) (NN carboxy) (NN terminus))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ basal) (NN transcription) (NN factor) (NN _PROT2_))) (PP (IN through) (NP (NP (DT a) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN in) (NP (NP (DT the) (NN yeast) (NN coactivator) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 8)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ basal) (NN transcription) (NN factor) (NN _PROT_))) (PP (IN through) (NP (NP (DT a) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN in) (NP (NP (DT the) (NN yeast) (NN coactivator) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 8)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN activation) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (JJ basal) (NN transcription) (NN factor) (NN _PROT1_))) (PP (IN through) (NP (NP (DT a) (NN domain)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN conserved) (PP (IN in) (NP (NP (DT the) (NN yeast) (NN coactivator) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 8)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (ADJP (JJ Consistent) (PP (IN with) (NP (NP (PRP$ its) (NN role)) (PP (IN as) (NP (DT a) (NN coactivator))))))) (, ,) (NP (NN _PROT1_)) (VP (VBZ augments) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (VBN phosphorylated) (NN _PROT2_)))) (S (VP (TO to) (VP (VB activate) (NP (NP (NN transcription)) (PP (IN of) (NP (JJ cAMP-responsive) (NNS genes))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Cloning)) (PP (IN of) (NP (NP (DT the) (JJ complete) (NN coding) (NN region)) (PP (IN for) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (VP (VBG using) (NP (NP (DT the) (CD two) (NN hybrid) (NN system)) (CC and) (NP (NP (NN expression)) (PP (IN of) (NP (NN _PROT2_) (CD _PROT2_))) (PP (IN in) (NP (FW E.) (FW coli)))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (JJ catalytic) (NN subunit))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ interacts) (PP (IN with) (NP (NP (JJ many) (JJ cellular) (NNS proteins)) (PP (IN in) (NP (NP (NNS complexes)) (ADJP (RB potentially) (JJ important) (PP (IN for) (NP (PRP$ its) (JJ growth-suppressing) (NN function)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD One) (NN clone)) (VP (VBZ encodes) (NP (NP (NP (DT a) (JJ novel) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ catalytic) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ differs) (PP (IN from) (NP (DT the) (ADJP (RB originally) (VBN defined)) (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (DT an) (JJ amino-terminal) (JJ 11-amino-acid) (NN insert))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD One) (NN clone)) (VP (VBZ encodes) (NP (NP (NP (DT a) (JJ novel) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ catalytic) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ differs) (PP (IN from) (NP (DT the) (ADJP (RB originally) (VBN defined)) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (DT an) (JJ amino-terminal) (JJ 11-amino-acid) (NN insert))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD One) (NN clone)) (VP (VBZ encodes) (NP (NP (NP (DT a) (JJ novel) (NN _PROT_) (CD _PROT_) (NN _PROT_) (NN _PROT_) (JJ catalytic) (NN subunit)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ differs) (PP (IN from) (NP (DT the) (ADJP (RB originally) (VBN defined)) (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (DT an) (JJ amino-terminal) (JJ 11-amino-acid) (NN insert))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (JJ vitro-binding) (NNS assays))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_) (NNS isoforms)) (ADVP (RB preferentially)) (VP (VBP bind) (NP (NP (DT the) (VBN hypophosphorylated) (NN form)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (JJ similar) (NN _PROT1_) (NNS sequences)) (VP (VBP are) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (CC and) (NP (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (JJ similar) (NN _PROT1_) (NNS sequences)) (VP (VBP are) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Moreover)) (, ,) (NP (JJ similar) (NN _PROT_) (NNS sequences)) (VP (VBP are) (VP (VBN required) (PP (IN for) (S (VP (VBG binding) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (CC and) (NP (NN _PROT2_) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ novel) (NN fold)) (PP (IN of) (NP (DT the) (NN TNF) (NN receptor) (NN structure)))) (VP (VBZ is) (ADJP (JJ likely) (S (VP (TO to) (VP (VB be) (ADJP (JJ representative) (PP (IN of) (NP (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN /TNF) (NN receptor) (NN family)) (PP (IN as) (NP (DT a) (JJ whole)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NP (NN _PROT1_) (NN binding) (NNS proteins)) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NP (NN _PROT1_) (NN binding) (NNS proteins)) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Characterization)) (PP (IN of) (NP (DT the) (NP (NN _PROT_) (NN binding) (NNS proteins)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN gene) (NN product)) (, ,) (NP (NN _PROT2_)) (, ,)) (VP (VBZ regulates) (NP (NN cell) (NN proliferation)) (PP (IN by) (S (VP (VP (VBG binding) (PP (TO to))) (CC and) (VP (VBG inhibiting) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (JJ key) (NN growth) (VBG promoting) (NNS proteins)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB now)) (VP (VBN isolated) (NP (NP (NN cDNA) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (DT the) (JJ full-length) (NN coding) (NN sequence)) (PP (IN of) (NP (NP (NP (CD two) (JJ other) (NNS proteins)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,)) (VP (VBN cloned) (ADVP (RB originally)) (PP (IN by) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NN _PROT_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB now)) (VP (VBN isolated) (NP (NP (NN cDNA) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (DT the) (JJ full-length) (NN coding) (NN sequence)) (PP (IN of) (NP (NP (NP (CD two) (JJ other) (NNS proteins)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (, ,)) (VP (VBN cloned) (ADVP (RB originally)) (PP (IN by) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB now)) (VP (VBN isolated) (NP (NP (NN cDNA) (NNS clones)) (SBAR (WHNP (WDT that)) (S (VP (VBP contain) (NP (NP (DT the) (JJ full-length) (NN coding) (NN sequence)) (PP (IN of) (NP (NP (NP (CD two) (JJ other) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (, ,)) (VP (VBN cloned) (ADVP (RB originally)) (PP (IN by) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT2_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT2_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS products)) (PP (IN of) (NP (DT the) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NNS genes)))) (VP (VBP are) (NP (NP (ADJP (ADJP (RB ubiquitously) (VBN expressed)) (, ,) (ADJP (ADJP (JJ large)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 200) (NN kDa)) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (NP (CD 195) (NN kDa)) (PP (IN for) (NP (NN _PROT2_))))) (-RRB- -RRB-)))) (JJ nuclear) (NNS phosphoproteins)) (PP (IN with) (NP (NP (JJ structural) (NNS motifs)) (SBAR (WHNP (WDT that)) (S (VP (VBP suggest) (NP (NP (DT a) (NN role)) (PP (IN in) (NP (JJ transcriptional) (NN regulation)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (NP (PRP we)) (VP (VBP have) (VP (VBN been) (ADJP (JJ able) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (ADVP (FW in) (FW vivo)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN dissociated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (VBN purified) (JJ human) (NN papillomavirus) (NN _PROT_) (NN protein))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (NP (PRP we)) (VP (VBP have) (VP (VBN been) (ADJP (JJ able) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (ADVP (FW in) (FW vivo)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN dissociated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (VBN purified) (JJ human) (NN papillomavirus) (NN _PROT2_) (NN protein))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (NP (PRP we)) (VP (VBP have) (VP (VBN been) (ADJP (JJ able) (S (VP (TO to) (VP (VB identify) (NP (NP (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (ADVP (FW in) (FW vivo)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN dissociated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (VBN purified) (JJ human) (NN papillomavirus) (NN _PROT2_) (NN protein))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NP (JJ vascular) (JJ endothelial) (NN growth) (NN factor)) (NNS determinants)) (PP (IN for) (S (VP (VBG binding) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN receptors.) (NN Generation))) (PP (IN of) (NP (JJ receptor-selective) (NN _PROT_) (NNS variants))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NP (JJ vascular) (JJ endothelial) (NN growth) (NN factor)) (NNS determinants)) (PP (IN for) (S (VP (VBG binding) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)) (NP (NN receptors.) (NN Generation))) (PP (IN of) (NP (JJ receptor-selective) (NN _PROT2_) (NNS variants))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Identification)) (PP (IN of) (NP (NP (NP (JJ vascular) (JJ endothelial) (NN growth) (NN factor)) (NNS determinants)) (PP (IN for) (S (VP (VBG binding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)) (NP (NN receptors.) (NN Generation))) (PP (IN of) (NP (JJ receptor-selective) (NN _PROT2_) (NNS variants))) (PP (IN by) (NP (JJ site-directed) (NN mutagenesis))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ _PROT1_) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN expression)) (PP (IN in) (NP (JJ various) (NN cell) (NNS types)))) (VP (VBZ is) (VP (VBN induced) (PP (IN by) (NP (NP (NN hypoxia)) (CC and) (NP (JJ other) (NNS stimuli))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT1_) (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ mediates) (NP (NP (JJ endothelial) (NN cell) (NN proliferation)) (, ,) (NP (NN angiogenesis)) (, ,) (NP (JJ vascular) (NN growth)) (, ,) (CC and) (NP (JJ vascular) (NN permeability))) (PP (IN via) (NP (NP (DT the) (JJ endothelial) (NN cell) (NNS receptors)) (, ,) (NP (NP (ADJP (NN _PROT_) (NN _PROT_) (JJ _PROT_)) (NN _PROT_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-)) (CC and) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Alanine-scanning) (NN mutagenesis)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (DT a) (ADJP (RB positively) (JJ charged)) (NN surface)) (PP (IN in) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ mediates) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Alanine-scanning) (NN mutagenesis)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (DT a) (ADJP (RB positively) (JJ charged)) (NN surface)) (PP (IN in) (NP (NN _PROT1_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ mediates) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Alanine-scanning) (NN mutagenesis)) (VP (VBD was) (VP (VBN used) (S (VP (TO to) (VP (VB identify) (NP (NP (DT a) (ADJP (RB positively) (JJ charged)) (NN surface)) (PP (IN in) (NP (NN _PROT_))) (SBAR (WHNP (WDT that)) (S (VP (VBZ mediates) (NP (NP (NN binding)) (PP (TO to) (NP (NN _PROT1_AND_PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Arg82)) (, ,) (NP (NP (NNP Lys84)) (CC and) (NP (NNP His86))) (, ,) (ADJP (JJ located) (PP (IN in) (NP (DT a) (NN hairpin) (NN loop)))) (, ,)) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT1_AND_PROT2_)))))) (, ,) (SBAR (IN while) (S (NP (NP (ADJP (RB negatively) (JJ charged)) (NNS residues)) (, ,) (NP (NP (NNP Asp63)) (, ,) (NP (NNP Glu64)) (, ,) (CC and) (NP (NNP Glu67))) (, ,)) (VP (VBD were) (VP (VBN associated) (PP (IN with) (NP (NN _PROT_) (NN binding))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Arg82)) (, ,) (NP (NP (NNP Lys84)) (CC and) (NP (NNP His86))) (, ,) (ADJP (JJ located) (PP (IN in) (NP (DT a) (NN hairpin) (NN loop)))) (, ,)) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT1_)))))) (, ,) (SBAR (IN while) (S (NP (NP (ADJP (RB negatively) (JJ charged)) (NNS residues)) (, ,) (NP (NP (NNP Asp63)) (, ,) (NP (NNP Glu64)) (, ,) (CC and) (NP (NNP Glu67))) (, ,)) (VP (VBD were) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_) (NN binding))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Arg82)) (, ,) (NP (NP (NNP Lys84)) (CC and) (NP (NNP His86))) (, ,) (ADJP (JJ located) (PP (IN in) (NP (DT a) (NN hairpin) (NN loop)))) (, ,)) (VP (VBD were) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADJP (JJ critical) (PP (IN for) (S (VP (VBG binding) (NP (NN _PROT1_)))))) (, ,) (SBAR (IN while) (S (NP (NP (ADJP (RB negatively) (JJ charged)) (NNS residues)) (, ,) (NP (NP (NNP Asp63)) (, ,) (NP (NNP Glu64)) (, ,) (CC and) (NP (NNP Glu67))) (, ,)) (VP (VBD were) (VP (VBN associated) (PP (IN with) (NP (NN _PROT2_) (NN binding))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN _PROT1_) (NN model)) (VP (VBN based) (PP (IN on) (NP (NN _PROT2_))))) (VP (VBD indicated) (S (NP (DT these) (ADJP (ADVP (ADVP (RB positively)) (CC and) (ADVP (RB negatively))) (JJ charged)) (NNS regions)) (VP (VP (VBP are) (ADJP (JJ distal) (PP (IN in) (NP (DT the) (NN monomer))))) (CC but) (VP (VBP are) (ADJP (RB spatially) (JJ close) (PP (IN in) (NP (DT the) (NN dimer))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT2_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT2_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT1_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT2_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT1_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT2_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT1_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT2_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NNS Mutations)) (PP (IN within) (NP (DT the) (NN _PROT_) (NN site)))) (VP (VBD had) (NP (JJ minimal) (NN effect)) (PP (IN on) (NP (NN _PROT_) (NN binding))))) (, ,) (CC and) (S (NP (NP (NNS mutants)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT1_) (NN binding))))) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN _PROT2_) (NN binding)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Endothelial) (NN cell) (NN mitogenesis)) (VP (VBD was) (VP (VBN abolished) (PP (IN in) (NP (NP (NNS mutants)) (VP (VBG lacking) (NP (NN _PROT1_) (NN affinity)))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NN _PROT2_) (JJ deficient) (NNS mutants)) (VP (VBD induced) (NP (JJ normal) (NN proliferation)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (DT this) (JJ mutational) (NN analysis)) (VP (VBZ implicates) (NP (NP (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))) (, ,) (PP (IN in) (NP (NP (NN _PROT_) (NN induction)) (PP (IN of) (NP (JJ endothelial) (NN cell) (NN proliferation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (DT this) (JJ mutational) (NN analysis)) (VP (VBZ implicates) (NP (NP (NN _PROT1_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_))) (, ,) (PP (IN in) (NP (NP (NN _PROT2_) (NN induction)) (PP (IN of) (NP (JJ endothelial) (NN cell) (NN proliferation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (DT this) (JJ mutational) (NN analysis)) (VP (VBZ implicates) (NP (NP (NN _PROT_)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_))) (, ,) (PP (IN in) (NP (NP (NN _PROT2_) (NN induction)) (PP (IN of) (NP (JJ endothelial) (NN cell) (NN proliferation))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN splicing) (NN factor) (NN U2AF)) (PRN (-LRB- -LRB-) (NP (NN U2) (NN snRNP) (NN auxiliary) (NN factor)) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (NN heterodimer)) (PP (IN with) (NP (NP (NNS subunits)) (PP (IN of) (NP (NP (NP (CD 65)) (CC and) (NP (CD 35) (NN kD))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB specifically)) (PP (TO to) (NP (CD 3) ('' ') (NN splice) (NNS sites))))) (, ,) (CC but) (S (NP (JJ previous) (NNS studies)) (VP (VBD failed) (S (VP (TO to) (VP (VB demonstrate) (NP (NP (DT a) (NN function)) (PP (IN for) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Nuclear) (NNS extracts)) (ADJP (JJ deficient) (PP (IN in) (NP (NN _PROT1_))))) (VP (VBD were) (ADJP (JJ inactive)))) (: ;) (S (ADVP (RB however)) (, ,) (NP (ADJP (CC both) (ADJP (JJ constitutive)) (CC and) (ADJP (JJ enhancer-dependent))) (NN splicing)) (VP (MD could) (VP (VB be) (VP (VBN restored) (PP (IN by) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (VBN purified) (JJ recombinant) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vitro)) (JJ protein-RNA) (NN interaction) (NNS studies)) (PP (IN with) (NP (NP (NNS pre-mRNAs)) (VP (VBG containing) (NP (CC either) (DT a) (ADJP (ADJP (JJ constitutive)) (CC or) (ADJP (JJ regulated))) (NN splicing) (NN enhancer)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ mediates) (NP (NP (NNS interactions)) (PP (IN between) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NNS proteins))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NNS enhancers)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN bridge)) (PP (IN between) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN enhancer) (NN complex)))))) (S (VP (TO to) (VP (VB recruit) (NP (NN _PROT_)) (PP (TO to) (NP (DT the) (JJ adjacent) (NN intron)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN bridge)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN enhancer) (NN complex)))))) (S (VP (TO to) (VP (VB recruit) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (JJ adjacent) (NN intron)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (VBZ functions) (PP (IN as) (NP (NP (DT a) (NN bridge)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN enhancer) (NN complex)))))) (S (VP (TO to) (VP (VB recruit) (NP (NN _PROT2_)) (PP (TO to) (NP (DT the) (JJ adjacent) (NN intron)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (CD _PROT2_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ growth-promoting) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ neoplastic))) (JJ gastrointestinal) (NNS tissues)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ belongs) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (ADJP (NN G) (JJ protein-coupled)) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ growth-promoting) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ neoplastic))) (JJ gastrointestinal) (NNS tissues)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ belongs) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (ADJP (NN G) (JJ protein-coupled)) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ growth-promoting) (NNS effects)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ neoplastic))) (JJ gastrointestinal) (NNS tissues)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ belongs) (PP (TO to) (NP (NP (DT the) (NN family)) (PP (IN of) (NP (ADJP (NN G) (JJ protein-coupled)) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ stimulates) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT the) (JJ major) (JJ cytoplasmic) (NN substrate)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ _PROT1_) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD was) (ADJP (ADJP (JJ rapid)) (CC and) (ADJP (JJ transient))) (, ,) (S (VP (VP (VBG occurring) (PP (IN within) (NP (NP (CD 30) (NN s)) (PP (IN of) (NP (NN treatment)))))) (CC and) (VP (VBG diminishing) (ADVP (RB thereafter))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT1_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT1_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (VBG Following) (NP (NN _PROT_) (NN stimulation))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN association)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (DT the) (NN _PROT_) (JJ regulatory) (NN subunit)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT2_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT2_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT2_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT1_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT1_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT2_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT1_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT_) (NN _PROT_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT1_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (VP (VBN detected) (PP (IN in) (NP (NP (NN _PROT_) (NNS immunoprecipitates)) (PP (IN from) (NP (JJ _PROT_) (NNS cells))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ leads) (PP (TO to) (NP (NP (DT the) (JJ rapid) (NN recruitment)) (PP (IN of) (NP (NN _PROT_)))))))) (, ,)) (VP (MD might) (VP (VB be) (NP (NP (CD one) (NN mechanism)) (VP (VBN used) (PP (IN by) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB activate) (NP (NN _PROT2_) (NN _PROT2_)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN pathway))) (PP (IN by) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (ADVP (RB previously)) (VP (VBN reported) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT_)))) (CC and) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN complex))))) (VP (MD may) (VP (VB contribute) (PP (TO to) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN pathway))) (PP (IN by) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (JJ tyrosine-phosphorylated) (NN _PROT2_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (JJ tyrosine-phosphorylated) (NN _PROT_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ interacts) (PP (IN with) (NP (JJ tyrosine-phosphorylated) (NN _PROT1_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT2_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT2_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT2_) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (ADJP (NN _PROT2_) (JJ _PROT2_)) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT1_) (ADJP (NN _PROT1_) (JJ _PROT1_)) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB serve) (PP (IN as) (NP (NP (DT a) (JJ converging) (NN target)) (PP (IN in) (NP (NP (DT the) (NN signaling) (NNS pathways)) (VP (VBN stimulated) (PP (IN by) (NP (NP (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP belong) (PP (TO to) (NP (JJ different) (NNS families)))))) (, ,) (PP (JJ such) (IN as) (NP (NP (DT the) (JJ _PROT_) (ADJP (NN _PROT_) (JJ _PROT_)) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Structure)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN oncoprotein)))) (VP (VBD bound) (PP (TO to) (NP (DT the) (NP (NN _PROT2_) (NN tumor) (NN suppressor)) (NN transactivation) (NN domain))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN oncoprotein)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN tumor) (NN suppressor))) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (MD can) (VP (VP (VB bind) (NP (NP (DT the) (NN transactivation) (NN domain)) (PP (IN of) (NP (NN _PROT_))))) (CC and) (VP (VB downregulate) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB activate) (NP (NN transcription)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN oncoprotein)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN tumor) (NN suppressor))) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (MD can) (VP (VP (VB bind) (NP (NP (DT the) (NN transactivation) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (CC and) (VP (VB downregulate) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB activate) (NP (NN transcription)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN oncoprotein)) (VP (VBZ is) (NP (NP (DT a) (JJ cellular) (NN inhibitor)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN tumor) (NN suppressor))) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (MD can) (VP (VP (VB bind) (NP (NP (DT the) (NN transactivation) (NN domain)) (PP (IN of) (NP (NN _PROT2_))))) (CC and) (VP (VB downregulate) (NP (PRP$ its) (NN ability) (S (VP (TO to) (VP (VB activate) (NP (NN transcription)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (JJ certain) (NNS cancers))) (, ,) (NP (NN _PROT1_) (NN amplification)) (VP (VP (VBZ is) (NP (DT a) (JJ common) (NN event))) (CC and) (VP (VBZ contributes) (PP (TO to) (NP (NP (DT the) (NN inactivation)) (PP (IN of) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT2_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT2_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT1_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT1_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT2_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NP (DT the) (JJ 109-residue) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_))) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (JJ 15-residue) (NN transactivation) (NN domain) (NN peptide)) (PP (IN of) (NP (NN _PROT_))))))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NP (DT a) (JJ deep) (JJ hydrophobic) (NN cleft)) (SBAR (WHPP (IN on) (WHNP (WDT which))) (S (NP (DT the) (NN _PROT2_) (NN peptide)) (VP (VBZ binds) (PP (IN as) (NP (DT an) (JJ amphipathic) (NN alpha) (NN helix)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT1_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT1_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT2_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT1_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT2_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT2_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT2_) (NN cleft))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN interface)) (VP (VBZ relies) (PP (PP (IN on) (NP (NP (NP (DT the) (JJ steric) (NN complementarity)) (PP (IN between) (NP (DT the) (NN _PROT_) (NN cleft)))) (CC and) (NP (NP (DT the) (JJ hydrophobic) (NN face)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN alpha) (NN helix)))))) (CC and) (, ,) (PP (IN in) (NP (JJ particular))) (, ,) (PP (IN on) (NP (NP (DT a) (NN triad)) (PP (IN of) (NP (NP (NN _PROT1_) (NN amino) (NN acids-Phe19)) (, ,) (NP (NN Trp23)) (, ,) (CC and) (NP (JJ Leu26-which) (NN insert) (NN deep)))) (PP (IN into) (NP (DT the) (NN _PROT2_) (NN cleft))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (JJ same) (NN _PROT1_) (NNS residues)) (VP (VBP are) (ADVP (RB also)) (VP (VBN involved) (PP (IN in) (NP (NN transactivation))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ inactivates) (NP (NN _PROT_)) (PP (IN by) (NP (NN concealing) (PRP$ its) (NN transactivation) (NN domain)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (JJ same) (NN _PROT1_) (NNS residues)) (VP (VBP are) (ADVP (RB also)) (VP (VBN involved) (PP (IN in) (NP (NN transactivation))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inactivates) (NP (NN _PROT2_)) (PP (IN by) (NP (NN concealing) (PRP$ its) (NN transactivation) (NN domain)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (JJ same) (NN _PROT_) (NNS residues)) (VP (VBP are) (ADVP (RB also)) (VP (VBN involved) (PP (IN in) (NP (NN transactivation))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inactivates) (NP (NN _PROT2_)) (PP (IN by) (NP (NN concealing) (PRP$ its) (NN transactivation) (NN domain)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (VP (VBZ processes) (NP (NP (DT the) (JJ inactive) (NN _PROT2_) (NN precursor)) (PP (TO to) (NP (DT the) (JJ proinflammatory) (NN cytokine)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBD was) (ADVP (RB also)) (VP (VBN shown) (S (VP (TO to) (VP (VB cleave) (NP (NP (DT the) (NN precursor)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN at) (NP (NP (DT the) (JJ authentic) (NN processing) (NN site)) (PP (IN with) (NP (JJ high) (NN efficiency))))) (, ,) (S (ADVP (RB thereby)) (VP (VP (VBG activating) (NP (NN _PROT2_))) (CC and) (VP (VBG facilitating) (NP (PRP$ its) (NN export))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Lipopolysaccharide-activated) (JJ _PROT1_) (-LRB- -LRB-) (JJ ICE-/-) (-RRB- -RRB-) (NN Kupffer) (NNS cells)) (VP (VP (VBD synthesized) (NP (DT the) (NN _PROT2_) (NN precursor))) (CC but) (VP (VBD failed) (S (VP (TO to) (VP (VB process) (NP (PRP it)) (PP (IN into) (NP (DT the) (JJ active) (NN form))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN diminished) (PP (IN in) (NP (NP (DT the) (NN sera)) (PP (IN of) (NP (NP (JJ _PROT_) (NNS mice)) (VP (VBN exposed) (PP (TO to) (NP (NP (NN Propionibacterium) (NNS acnes)) (CC and) (NP (NN lipopolysaccharide)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN diminished) (PP (IN in) (NP (NP (DT the) (NN sera)) (PP (IN of) (NP (NP (JJ _PROT2_) (NNS mice)) (VP (VBN exposed) (PP (TO to) (NP (NP (NN Propionibacterium) (NNS acnes)) (CC and) (NP (NN lipopolysaccharide)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBD were) (VP (VBN diminished) (PP (IN in) (NP (NP (DT the) (NN sera)) (PP (IN of) (NP (NP (JJ _PROT2_) (NNS mice)) (VP (VBN exposed) (PP (TO to) (NP (NP (NN Propionibacterium) (NNS acnes)) (CC and) (NP (NN lipopolysaccharide)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Through) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN ErbB) (NN family)) (PP (IN of) (NP (NP (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-)))))))) (, ,) (NP (NNS neuregulins)) (VP (VB help) (S (VP (TO to) (VP (VB regulate) (NP (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN in) (NP (JJ many) (NNS tissues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Through) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN ErbB) (NN family)) (PP (IN of) (NP (NP (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))) (, ,) (NP (NNS neuregulins)) (VP (VB help) (S (VP (TO to) (VP (VB regulate) (NP (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN in) (NP (JJ many) (NNS tissues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Through) (NP (NP (PRP$ their) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN ErbB) (NN family)) (PP (IN of) (NP (NP (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-)))))))) (, ,) (NP (NNS neuregulins)) (VP (VB help) (S (VP (TO to) (VP (VB regulate) (NP (NP (NP (NN cell) (NN growth)) (CC and) (NP (NN differentiation))) (PP (IN in) (NP (JJ many) (NNS tissues))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN encoded) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene)))) (VP (VBZ has) (NP (NP (DT a) (NN motif) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (PP (IN of) (NP (NNS neuregulins))))))))) (CC and) (S (NP (NP (DT an) (JJ alternative) (NN splicing) (NN site)) (PP (IN in) (NP (DT the) (ADJP (NP (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (JJ -like)) (NN domain)))) (VP (VBZ gives) (NP (NN rise)) (PP (TO to) (NP (NP (CD two) (NNS isoforms)) (PRN (-LRB- -LRB-) (NP (NP (NN alpha)) (CC and) (NP (NN beta))) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN encoded) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene)))) (VP (VBZ has) (NP (NP (DT a) (NN motif) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (PP (IN of) (NP (NNS neuregulins))))))))) (CC and) (S (NP (NP (DT an) (JJ alternative) (NN splicing) (NN site)) (PP (IN in) (NP (DT the) (ADJP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -like)) (NN domain)))) (VP (VBZ gives) (NP (NN rise)) (PP (TO to) (NP (NP (CD two) (NNS isoforms)) (PRN (-LRB- -LRB-) (NP (NP (NN alpha)) (CC and) (NP (NN beta))) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (DT The) (VBN encoded) (NN product)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene)))) (VP (VBZ has) (NP (NP (DT a) (NN motif) (NN structure)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (PP (IN of) (NP (NNS neuregulins))))))))) (CC and) (S (NP (NP (DT an) (JJ alternative) (NN splicing) (NN site)) (PP (IN in) (NP (DT the) (ADJP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (JJ -like)) (NN domain)))) (VP (VBZ gives) (NP (NN rise)) (PP (TO to) (NP (NP (CD two) (NNS isoforms)) (PRN (-LRB- -LRB-) (NP (NP (NN alpha)) (CC and) (NP (NN beta))) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT1_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Recombinant) (NN _PROT_)) (VP (VBZ induces) (NP (NP (DT the) (NN tyrosine-phosphorylation)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (VP (VBG expressing) (NP (NP (DT all)) (PP (IN of) (NP (DT these) (JJ ErbB-family) (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT1_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT2_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and/or) (NP (NN _PROT_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (NN cell) (NNS lines)) (PP (IN with) (NP (NP (VBN defined) (NNS combinations)) (PP (IN of) (NP (NNS ErbBs))))))) (, ,) (NP (NN _PROT_)) (ADVP (RB only)) (VP (VBZ activates) (NP (NP (DT those)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and/or) (NP (NN _PROT_))))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NP (NN signalling)) (PP (IN by) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and/or) (NP (NN _PROT2_)) (NP (NNS receptors)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT2_))) (NN _PROT_) (NN surface) (NN expression)) (VP (VBZ correlates) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT an) (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN peptide))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (JJ _PROT1_)) (CC and) (ADJP (JJ _PROT_))) (NN _PROT2_) (NN surface) (NN expression)) (VP (VBZ correlates) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT an) (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN peptide))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ _PROT1_))) (NN _PROT2_) (NN surface) (NN expression)) (VP (VBZ correlates) (PP (IN with) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (DT an) (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN peptide))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_) (NN surface) (NN expression)) (VP (VBZ is) (VP (VBN correlated) (PP (IN with) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NN MHC) (NN class) (NN I) (NNS molecules)) (SBAR (WHNP (WDT which)) (S (VP (VBP provide) (NP (NP (JJ suitable) (NN leader) (NN sequence) (NNS peptides)) (ADJP (JJ capable) (PP (IN of) (S (VP (VBG binding) (PP (TO to) (NP (NN _PROT2_))))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (VP (VBN _PROT2_) (PP (IN _PROT2_) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (VP (VBN _PROT2_) (PP (IN _PROT2_) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (VP (VBN _PROT1_) (PP (IN _PROT1_) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Further) (NNS studies)) (PP (IN on) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NNS molecules)) (PP (IN in) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))))) (VP (VBD revealed) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ associates) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (VP (VBN _PROT_) (PP (IN _PROT_) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN _PROT1_) (NN expression)) (VP (VBZ is) (ADJP (ADJP (JJ _PROT2_)) (CC and) (ADJP (JJ tapasin-dependent))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN _PROT1_)) (VP (VBZ dissociates) (PP (IN from) (NP (NN _PROT2_))) (PP (IN upon) (NP (NP (NN binding)) (PP (IN of) (NP (NP (NN MHC) (NN class) (CD I)) (NN leader) (NN sequence) (NNS peptides))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN correlation)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN MHC) (NN class) (CD I)) (NN surface) (NN expression))))) (VP (MD might) (VP (VB be) (ADJP (JJ relevant) (PP (TO to) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (, ,) (SBAR (IN although) (S (NP (DT these) (JJ _PROT1_) (NN binding) (NNS peptides)) (VP (VBP are) (VP (VBN derived) (PP (IN from) (NP (NN signal) (NNS sequences))))))) (, ,) (NP (PRP they)) (VP (MD may) (VP (VB be) (VP (VP (VBN released) (ADVP (RB back)) (PP (IN into) (NP (DT the) (NN cytosol)))) (CC and) (VP (ADVP (RB subsequently)) (VBN translocated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN complex)))) (CC and) (VP (VBN loaded) (PP (IN onto) (NP (JJ _PROT_) (NNS molecules))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (, ,) (SBAR (IN although) (S (NP (DT these) (JJ _PROT1_) (NN binding) (NNS peptides)) (VP (VBP are) (VP (VBN derived) (PP (IN from) (NP (NN signal) (NNS sequences))))))) (, ,) (NP (PRP they)) (VP (MD may) (VP (VB be) (VP (VP (VBN released) (ADVP (RB back)) (PP (IN into) (NP (DT the) (NN cytosol)))) (CC and) (VP (ADVP (RB subsequently)) (VBN translocated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN complex)))) (CC and) (VP (VBN loaded) (PP (IN onto) (NP (JJ _PROT2_) (NNS molecules))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (, ,) (SBAR (IN although) (S (NP (DT these) (JJ _PROT_) (NN binding) (NNS peptides)) (VP (VBP are) (VP (VBN derived) (PP (IN from) (NP (NN signal) (NNS sequences))))))) (, ,) (NP (PRP they)) (VP (MD may) (VP (VB be) (VP (VP (VBN released) (ADVP (RB back)) (PP (IN into) (NP (DT the) (NN cytosol)))) (CC and) (VP (ADVP (RB subsequently)) (VBN translocated) (PP (IN by) (NP (DT the) (NN _PROT1_) (NN complex)))) (CC and) (VP (VBN loaded) (PP (IN onto) (NP (JJ _PROT2_) (NNS molecules))))))))))) (. .))) |ET|
