-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NN BACKGROUND)) (: :) (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NP (JJ epidermal) (NN growth) (NN factor)) (NP (NN receptor) (NN family) (NNS members))) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (CC and) (NP (NN tumor) (NN recurrence)))))))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (S (VP (VBG Using) (NP (NN Cox) (NN univariate) (NN analysis)))) (, ,) (NP (PRP we)) (VP (VBD determined) (SBAR (SBAR (IN that) (S (NP (NP (JJ angiolymphatic) (NN tumor) (NNS emboli)) (CC and) (NP (JJ non-well-differentiated) (NN tumor) (NNS cells))) (VP (VBD were) (NP (NP (CD two) (JJ significant) (JJ conventional) (JJ pathologic) (NNS predictors)) (PP (IN of) (NP (NN tumor) (NN recurrence))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB also)) (NP (JJ significant) (NNS predictors)))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ Several) (NNS genes)) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN process)))))) (, ,) (CC and) (S (NP (CD two)) (VP (VBP have) (VP (VBN been) (NP (NP (DT the) (NN focus)) (PP (IN of) (NP (JJ recent) (NN interest)))))))) (: :) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT2_) (-RRB- -RRB-) (NN gene)) (CC and) (NP (NP (DT the) (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ Several) (NNS genes)) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN process)))))) (, ,) (CC and) (S (NP (CD two)) (VP (VBP have) (VP (VBN been) (NP (NP (DT the) (NN focus)) (PP (IN of) (NP (JJ recent) (NN interest)))))))) (: :) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN _PROT_) (-RRB- -RRB-) (NN gene)) (CC and) (NP (NP (DT the) (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (JJ Several) (NNS genes)) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (DT this) (NN process)))))) (, ,) (CC and) (S (NP (CD two)) (VP (VBP have) (VP (VBN been) (NP (NP (DT the) (NN focus)) (PP (IN of) (NP (JJ recent) (NN interest)))))))) (: :) (NP (NP (DT the) (JJ _PROT_) (JJ _PROT_) (NN _PROT_) (-LRB- -LRB-) (NN _PROT1_) (-RRB- -RRB-) (NN gene)) (CC and) (NP (NP (DT the) (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT_) (JJ _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (NN _PROT_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN identified) (NP (NP (NP (DT a) (JJ new) (JJ TNF-related) (NN ligand)) (, ,) (NP (NP (JJ designated) (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (PRP$ its) (JJ human) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (, ,) (NP (NP (DT an) (NN ortholog)) (PP (IN of) (NP (DT the) (ADJP (RB recently) (VBN discovered)) (JJ murine) (JJ _PROT2_) (JJ _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (NN _PROT2_) (CD [4))) (-RRB- -RSB-)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene)) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 1q23))) (, ,) (PP (IN near) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN TNF) (NN homolog) (NN _PROT2_) (NN _PROT_) (NN [5)))))) (-RRB- -RSB-)) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT1_) (NN gene)) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 1q23))) (, ,) (PP (IN near) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN TNF) (NN homolog) (NN _PROT2_) (NN _PROT2_) (NN [5)))))) (-RRB- -RSB-)) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN _PROT_) (NN gene)) (VP (VBD mapped) (PP (TO to) (NP (NN chromosome) (CD 1q23))) (, ,) (PP (IN near) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN TNF) (NN homolog) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN [5)))))) (-RRB- -RSB-)) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VP (VBD found) (NP (NN _PROT1_) (NN mRNA)) (PP (IN in) (NP (JJ several) (JJ peripheral) (NNS tissues)))) (, ,) (CC and) (VP (VBD detected) (NP (NN _PROT2_) (NN protein)) (PP (IN on) (NP (VBN cultured) (JJ vascular) (JJ endothelial) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS levels)) (PP (IN of) (NP (NN _PROT1_) (NN mRNA))) (PP (IN in) (NP (NNS tissues)))) (VP (VBD were) (ADJP (RB generally) (JJ low)))) (: ;) (S (PP (IN in) (NP (JJ peripheral) (NN blood) (NN T) (NNS cells))) (, ,) (ADVP (RB however)) (, ,) (NP (NN antigen-receptor) (NN stimulation)) (VP (VBD led) (PP (TO to) (NP (NP (DT a) (JJ substantial) (NN induction)) (PP (IN of) (NP (NN _PROT2_) (NNS transcripts))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT2_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT2_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT1_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (JJ embryonic) (NN kidney) (CD 293) (NNS cells)))) (VP (VBD activated) (NP (DT the) (JJ anti-apoptotic) (NN transcription) (NN factor) (NN _PROT_)) (, ,) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBD appeared) (S (VP (TO to) (VP (VB involve) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (-RRB- -RRB-) (CD [7)) (-RRB- -RSB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (-RRB- -RRB-) (CD [8)) (-RRB- -RSB-)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Cotransfection)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NN Jurkat) (NN T) (NN leukemia) (NNS cells)))) (VP (VBD inhibited) (NP (JJ antigen-receptor-induced) (NN cell) (NN death)))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB modulate) (NP (NN T) (NN lymphocyte) (NN survival)) (PP (IN in) (NP (JJ peripheral) (NNS tissues)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (ADJP (RB newly) (VBN identified)) (NN member)) (PP (IN of) (NP (NP (NN tumor) (NN necrosis) (NN factor) (NN receptor) (NN superfamily)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBZ suppresses) (NP (JJ _PROT2_) (NN apoptosis)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (-RRB- -RRB-))) (VP (VBZ is) (NP (NP (DT a) (JJ new) (NN member)) (PP (IN of) (NP (DT the) (NN tumor) (NN necrosis) (NN factor) (NN receptor) (-LRB- -LRB-) (NN TNFR) (-RRB- -RRB-) (NN family)))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT2_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT1_AND_PROT2_) (-RRB- _PROT2_) (CD _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT1_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- _PROT1_) (NN _PROT1_) (-RRB- _PROT1_) (CD _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ binds) (NP (NP (CD two) (JJ cellular) (NNS ligands)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (-LRB- _PROT_) (NN _PROT_) (-RRB- _PROT_) (CD _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD inhibited) (NP (NP (JJ _PROT2_) (NN cytotoxicity)) (PP (IN in) (NP (NN HT29) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ triggers) (NP (NP (NN apoptosis)) (PP (IN of) (NP (NP (JJ various) (NN tumor) (NNS cells)) (PP (VBG including) (NP (NP (NN HT29) (NNS cells)) (SBAR (WHNP (WDT that)) (S (VP (VBP express) (NP (CC both) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NN _PROT1_AND_PROT2_) (NNS receptors)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_AND_PROT2_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ inhibits) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG suppressing) (NP (JJ _PROT2_) (JJ mediated) (NN HT29) (NN cell) (NN death))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ _PROT_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (JJ _PROT2_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT_)) (VP (MD may) (VP (VB play) (NP (DT a) (JJ regulatory) (NN role)) (PP (IN for) (S (VP (VBG suppressing) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ _PROT2_) (NN cell) (NN death)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NNS mutations)) (VP (VBP account) (PP (IN for) (NP (NP (DT the) (NN majority)) (PP (IN of) (NP (NP (JJ early-onset) (JJ dominant) (NNS cases)) (PP (IN of) (NP (JJ familial) (NN Alzheimer) (POS 's) (NN disease))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NP (NP (JJ human) (NN _PROT1_)) (CC or) (NP (NN _PROT2_))) (JJ hydrophilic) (NN loop)) (CC and) (NP (NN _PROT_))) (, ,) (NP (NP (DT a) (JJ small) (NN GTPase)) (VP (VBG belonging) (PP (TO to) (NP (DT the) (JJ Ras-related) (NN superfamily)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NP (NP (JJ human) (NN _PROT1_)) (CC or) (NP (NN _PROT_))) (JJ hydrophilic) (NN loop)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (DT a) (JJ small) (NN GTPase)) (VP (VBG belonging) (PP (TO to) (NP (DT the) (JJ Ras-related) (NN superfamily)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP report) (NP (NP (DT an) (NN interaction)) (PP (IN between) (NP (NP (NP (DT the) (NP (NP (JJ human) (NN _PROT_)) (CC or) (NP (NN _PROT1_))) (JJ hydrophilic) (NN loop)) (CC and) (NP (NN _PROT2_))) (, ,) (NP (NP (DT a) (JJ small) (NN GTPase)) (VP (VBG belonging) (PP (TO to) (NP (DT the) (JJ Ras-related) (NN superfamily)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN Interaction) (NNS domains)) (VP (VBD were) (VP (VBN mapped) (PP (PP (TO to) (NP (NP (NNS codons) (CD 374-400)) (PP (IN for) (NP (NN _PROT1_))))) (CC and) (PP (TO to) (NP (NP (NNS codons) (CD 106-179)) (PP (IN for) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (NN region)) (VP (VBG including) (NP (DT the) (JJ fourth) (JJ GTP-binding) (NN domain)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (JJ mutant) (NN form)) (PP (IN of) (NP (NP (JJ human) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ binds) (NP (NP (CD one) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))))) (VP (VBZ has) (VP (VBN been) (VP (VP (VBN designed)) (CC and) (VP (VBN characterized)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (VP (VBD was) (VP (VBN derived) (PP (IN by) (S (VP (VP (VBG linking) (NP (NP (DT the) (CD two) (NN peptide) (NNS chains)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN dimer)))) (PP (IN by) (NP (DT a) (JJ seven-residue) (NN linker)))) (CC and) (VP (VBG changing) (NP (NP (NN His111)) (PP (IN in) (NP (DT the) (JJ first) (NN chain)))) (PP (TO to) (NP (DT an) (JJ aspartic) (NN acid) (NN residue)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT_)) (VP (VBD was) (VP (VBN derived) (PP (IN by) (S (VP (VP (VBG linking) (NP (NP (DT the) (CD two) (NN peptide) (NNS chains)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN dimer)))) (PP (IN by) (NP (DT a) (JJ seven-residue) (NN linker)))) (CC and) (VP (VBG changing) (NP (NP (NN His111)) (PP (IN in) (NP (DT the) (JJ first) (NN chain)))) (PP (TO to) (NP (DT an) (JJ aspartic) (NN acid) (NN residue)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD was) (VP (VBN derived) (PP (IN by) (S (VP (VP (VBG linking) (NP (NP (DT the) (CD two) (NN peptide) (NNS chains)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN dimer)))) (PP (IN by) (NP (DT a) (JJ seven-residue) (NN linker)))) (CC and) (VP (VBG changing) (NP (NP (NN His111)) (PP (IN in) (NP (DT the) (JJ first) (NN chain)))) (PP (TO to) (NP (DT an) (JJ aspartic) (NN acid) (NN residue)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Isothermal) (NN titration) (NN calorimetry)) (VP (VBZ shows) (SBAR (IN that) (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ forms) (NP (NP (DT a) (JJ 1:1) (NN complex)) (PP (IN with) (NP (NP (NP (PRP$ its) (JJ high-affinity) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (QP (QP (CD 27)) (PRN (-LRB- -LRB-) (NP (CC +/-) (CD 9)) (-RRB- -RRB-))) (NN nM))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN crystal) (NN structure)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)))) (VP (VBZ has) (VP (VBN been) (VP (VBN determined) (PP (IN at) (NP (NP (CD 2.9) (DT A) (NN resolution)) (PP (IN from) (NP (NP (NNS crystals)) (VP (VBN grown) (PP (IN in) (NP (ADJP (CD 1.4) (NN M)) (NN citrate) (NNS solutions))) (PP (IN at) (NP (NN pH) (CD 7.6)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Comparison)) (PP (IN of) (NP (NP (DT the) (JJ wild-type) (JJ receptor-binding) (NN domain)) (CC and) (NP (NP (DT the) (JJ Asp111-containing) (NN domain)) (PP (IN of) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))) (VP (VBP show) (SBAR (IN that) (S (NP (PRP they)) (VP (VP (VBP are) (ADJP (RB structurally) (JJ equivalent))) (CC but) (VP (VBP have) (NP (ADJP (RB very) (JJ different)) (JJ electrostatic) (NN surface) (NNS potentials)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT_) (NN _PROT_) (NN complex)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN AB) (NNS loops)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBP adopt) (NP (NP (NNS conformations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT the) (VBN ordered) (NNS loops)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN observed) (PP (IN in) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN complex)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN binding)) (VP (VBZ does) (RB not) (VP (VB result) (PP (IN in) (NP (NP (DT a) (JJ large) (JJ conformational) (NN change)) (PP (IN in) (NP (DT the) (NN AB) (NN loop))))) (SBAR (IN as) (S (ADVP (RB previously)) (VP (VBN suggested))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (ADVP (RB also)) (VP (VBZ reveals) (NP (NP (DT the) (JJ final) (CD six) (JJ C-terminal) (NN amino) (NN acid) (NNS residues)) (PP (IN of) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 253-258))) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN observed) (PP (IN in) (NP (DT any) (JJ other) (VBN reported) (NN _PROT_) (NNS structures))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (ADVP (RB also)) (VP (VBZ reveals) (NP (NP (DT the) (JJ final) (CD six) (JJ C-terminal) (NN amino) (NN acid) (NNS residues)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 253-258))) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN observed) (PP (IN in) (NP (DT any) (JJ other) (VBN reported) (NN _PROT2_) (NNS structures))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NN structure)) (ADVP (RB also)) (VP (VBZ reveals) (NP (NP (DT the) (JJ final) (CD six) (JJ C-terminal) (NN amino) (NN acid) (NNS residues)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 253-258))) (-RRB- -RRB-)))) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (RB not) (VP (VBN been) (VP (VBN observed) (PP (IN in) (NP (DT any) (JJ other) (VBN reported) (NN _PROT2_) (NNS structures))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Despite) (NP (NP (NN binding)) (PP (TO to) (NP (QP (RB only) (CD one)) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_))))) (, ,) (NP (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (ADJP (RB biologically) (JJ active) (PP (IN in) (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NP (NN MHC) (NN class) (CD I)) (NN induction)) (, ,) (CC and) (NP (JJ anti-viral) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN Despite) (NP (NP (NN binding)) (PP (TO to) (NP (QP (RB only) (CD one)) (NN _PROT1_) (NN _PROT_) (NN _PROT_))))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (VP (VBZ is) (ADJP (RB biologically) (JJ active) (PP (IN in) (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NP (NN MHC) (NN class) (CD I)) (NN induction)) (, ,) (CC and) (NP (JJ anti-viral) (NNS assays))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN Despite) (NP (NP (NN binding)) (PP (TO to) (NP (QP (RB only) (CD one)) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (VP (VBZ is) (ADJP (RB biologically) (JJ active) (PP (IN in) (NP (NP (NN cell) (NN proliferation)) (, ,) (NP (NP (NN MHC) (NN class) (CD I)) (NN induction)) (, ,) (CC and) (NP (JJ anti-viral) (NNS assays))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT_) (NN _PROT_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (CD one) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB recruit) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN into) (NP (NP (DT a) (NN complex)) (ADJP (JJ competent) (PP (IN for) (S (VP (VBG eliciting) (NP (JJ biological) (NN activity))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ current) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (S (NP (NP (DT the) (JJ main) (NN role)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN dimer)))) (VP (VBG being) (S (VP (TO to) (VP (VB decrease) (NP (NP (DT the) (NN dissociation) (NN constant)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN for) (NP (PRP$ its) (JJ cellular) (NNS receptors))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Human) (NN _PROT1_) (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ new) (NN cyclin)) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (CD two) (NNS members)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene) (NN family))))))))) (. .)))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD showed) (NP (NP (JJ genetic) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN gene)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD functioned) (PP (IN at) (NP (NN START))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (DT the) (NN _PROT_) (NN protein))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBD showed) (NP (NP (JJ genetic) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT_) (NN gene)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD functioned) (PP (IN at) (NP (NN START))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN protein))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN _PROT_)) (VP (VBD showed) (NP (NP (JJ genetic) (NNS interactions)) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN gene)))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD functioned) (PP (IN at) (NP (NN START))) (PP (IN by) (S (VP (VBG interacting) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN protein))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (CD Two) (JJ human) (NNS genes)) (VP (VBD were) (VP (VBN identified) (SBAR (WHNP (WDT that)) (S (VP (MD could) (VP (VB interact) (PP (IN with) (NP (NN _PROT1_) (NN _PROT1_))) (S (VP (TO to) (VP (VB perform) (NP (NN START)) (PP (IN in) (NP (NP (NN yeast)) (VP (VBG containing) (NP (DT a) (NN _PROT2_) (NN mutation))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN One)) (VP (VBD was) (NP (NN _PROT1_AND_PROT2_)))) (, ,) (CC and) (S (NP (DT the) (JJ second)) (VP (VBD was) (NP (NP (DT the) (JJ human) (NN homolog)) (PP (IN of) (NP (NN Xenopus) (NN _PROT_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN One)) (VP (VBD was) (NP (NN _PROT1_)))) (, ,) (CC and) (S (NP (DT the) (JJ second)) (VP (VBD was) (NP (NP (DT the) (JJ human) (NN homolog)) (PP (IN of) (NP (NN Xenopus) (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NN One)) (VP (VBD was) (NP (NN _PROT1_)))) (, ,) (CC and) (S (NP (DT the) (JJ second)) (VP (VBD was) (NP (NP (DT the) (JJ human) (NN homolog)) (PP (IN of) (NP (NN Xenopus) (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBN produced) (PP (IN in) (NP (FW E.) (FW coli))))) (VP (VP (VBD bound)) (CC and) (VP (VBD activated) (NP (DT the) (NN _PROT2_) (NN protein)) (PP (IN in) (NP (NP (NNS extracts)) (PP (IN from) (NP (JJ human) (NN G1) (NNS cells)))))))) (, ,) (CC and) (S (NP (NP (NNS antibodies)) (PP (IN against) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD immunoprecipitated) (NP (NP (DT a) (NN histone) (NN H1) (NN kinase)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBN produced) (PP (IN in) (NP (FW E.) (FW coli))))) (VP (VP (VBD bound)) (CC and) (VP (VBD activated) (NP (DT the) (NN _PROT_) (NN protein)) (PP (IN in) (NP (NP (NNS extracts)) (PP (IN from) (NP (JJ human) (NN G1) (NNS cells)))))))) (, ,) (CC and) (S (NP (NP (NNS antibodies)) (PP (IN against) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBD immunoprecipitated) (NP (NP (DT a) (NN histone) (NN H1) (NN kinase)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN _PROT_) (NN _PROT_)) (VP (VBN produced) (PP (IN in) (NP (FW E.) (FW coli))))) (VP (VP (VBD bound)) (CC and) (VP (VBD activated) (NP (DT the) (NN _PROT1_) (NN protein)) (PP (IN in) (NP (NP (NNS extracts)) (PP (IN from) (NP (JJ human) (NN G1) (NNS cells)))))))) (, ,) (CC and) (S (NP (NP (NNS antibodies)) (PP (IN against) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBD immunoprecipitated) (NP (NP (DT a) (NN histone) (NN H1) (NN kinase)) (PP (IN from) (NP (NN HeLa) (NNS cells))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_)) (, ,) (CC or) (NP (NN _PROT_)) (, ,))))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN at) (NP (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)) (PP (IN in) (NP (JJ human) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT_)) (, ,) (CC or) (NP (NN _PROT2_)) (, ,))))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN at) (NP (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)) (PP (IN in) (NP (JJ human) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NNS interactions)) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT1_)) (, ,) (CC or) (NP (NN _PROT2_)) (, ,))))) (VP (MD may) (VP (VB be) (ADJP (JJ important) (PP (IN at) (NP (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)) (PP (IN in) (NP (JJ human) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT1_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Evidence)) (PP (IN for) (NP (NP (DT a) (JJ differential) (NN interaction)) (PP (IN of) (NP (NN _PROT_)))))) (CC and) (NP (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (PP (IN with) (NP (NP (NP (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)) (PP (IN in) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system)) (, ,) (NP (NP (DT a) (JJ genetic) (NN assay)) (PP (IN for) (S (VP (VBG studying) (NP (JJ protein-protein) (NNS interactions))))))))) (, ,) (S (NP (PRP we)) (VP (VBP have) (VP (VP (VBN examined)) (CC and) (VP (VBN compared) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (DT the) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))))) (PP (IN with) (NP (PRP$ their) (NP (CD two) (JJ known) (NNS substrates) (NP (NP (NN _PROT_)) (CC and) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD mapped) (NP (NP (DT the) (JJ specific) (NNS domains)) (PP (IN of) (NP (NP (DT the) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBG participating) (PP (IN in) (NP (DT these) (NNS interactions))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT1_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT2_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT2_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT1_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT2_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT1_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_)))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS findings)) (VP (MD can) (VP (VB be) (VP (VBN summarized) (SBAR (IN as) (S (VP (VBZ follows) (S (: :) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN tyrosine) (NN kinase) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT_)))) (VP (VBZ is) (ADJP (JJ essential) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) (, ,) (S (NP (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (CC and) (NP (NN _PROT_))) (VP (VBP bind) (PP (TO to) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (DT the) (NN NPEY-juxtamembrane) (NN motif))))) (, ,) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (JJ contrary) (TO to) (NN _PROT_) (, ,) (S (S (NP (NN _PROT_)) (VP (VBZ binds) (ADVP (RB also)) (PP (TO to) (NP (NP (NP (DT the) (JJ major) (NN autophosphorylation) (NNS sites)) (PRN (-LRB- -LRB-) (QP (CD Tyr-1131) (, ,) (CD -1135) (, ,) (CC and) (CD -1136)) (-RRB- -RRB-))) (PP (IN of) (NP (DT the) (NN _PROT_))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS iv) (-RRB- -RRB-)) (NP (NP (DT the) (JJ amino-terminal) (NN domain)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (PRP$ its) (NN association)) (PP (IN with) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT1_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT2_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (NP (NP (DT the) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT_))) (VP (VBP share) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (NP (NP (DT the) (JJ same) (JJ molecular) (NN mechanism)) (VP (VBG underlying) (NP (NP (PRP$ their) (NN interplay)) (PP (IN with) (NP (NP (PRP$ their) (CD two) (NNS substrates)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))) (, ,) (CC and) (S (NP (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (DT the) (NN _PROT1_))) (PP (IN in) (NP (NP (DT a) (NN fashion)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ different) (PP (IN from) (SBAR (IN that) (S (VP (VBN used) (PP (IN by) (NP (NN _PROT2_))))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Finally)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP highlight) (NP (NP (DT the) (JJ crucial) (NN role)) (PP (IN of) (NP (DT the) (NN juxtamembrane) (NN domain))) (PP (IN in) (NP (NP (NN signaling)) (PP (IN by) (NP (CC both) (NP (DT the) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT the) (NN calibration))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (CD two) (NNS sets)) (PP (IN of) (NP (NP (NNS proteins)) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ helix-loop-helix) (NNS proteins)) (, ,) (CC and) (NP (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ dimerization-defective))) (NNS versions)) (PP (IN of) (NP (DT the) (NN lambda) (NN cI) (NN repressor))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT the) (NN calibration))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (CD two) (NNS sets)) (PP (IN of) (NP (NP (NNS proteins)) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ helix-loop-helix) (NNS proteins)) (, ,) (CC and) (NP (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ dimerization-defective))) (NNS versions)) (PP (IN of) (NP (DT the) (NN lambda) (NN cI) (NN repressor))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT the) (NN calibration))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (CD two) (NNS sets)) (PP (IN of) (NP (NP (NNS proteins)) (, ,) (NP (DT the) (NN _PROT1_AND_PROT2_) (JJ helix-loop-helix) (NNS proteins)) (, ,) (CC and) (NP (NP (ADJP (ADJP (JJ wild-type)) (CC and) (ADJP (JJ dimerization-defective))) (NNS versions)) (PP (IN of) (NP (DT the) (NN lambda) (NN cI) (NN repressor))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN interaction)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (NNS ties) (NP (JJ mitogenic) (NN signal) (NN transduction)) (PP (TO to) (NP (NN cell) (NN cycle) (NN activation))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS proto-oncogenes)) (VP (VBP transduce) (NP (NP (JJ extracellular) (NNS signals)) (SBAR (WHNP (WDT that)) (S (VP (VBP promote) (NP (NN cell) (NN growth)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP show) (ADVP (RB here)) (SBAR (IN that) (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ associates) (PP (IN with) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ somatic) (JJ mammalian) (NNS cells))) (CC and) (PP (IN in) (NP (JJ meiotic) (NN frog) (NNS oocytes))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Furthermore)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (VP (MD can) (VP (VB be) (VP (VBN activated) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (DT a) (JJ _PROT2_) (NN manner))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle))) (PP (IN by) (NP (DT the) (NN _PROT1_AND_PROT2_) (NNS pathways)))) (VP (MD might) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NN _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle))) (PP (IN by) (NP (DT the) (NN _PROT1_) (NNS pathways)))) (VP (MD might) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN cell) (NN cycle))) (PP (IN by) (NP (DT the) (NN _PROT1_) (NNS pathways)))) (VP (MD might) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (JJ direct) (NN interaction)) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN serine/threonine) (NN protein) (NN kinase)) (VP (VBN positioned) (ADVP (RB downstream) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (NP (DT the) (JJ _PROT_) (NN _PROT_) (NN _PROT_) (NN cascade))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN serine/threonine) (NN protein) (NN kinase)) (VP (VBN positioned) (ADVP (RB downstream) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN cascade))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (NN serine/threonine) (NN protein) (NN kinase)) (VP (VBN positioned) (ADVP (RB downstream) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN cascade))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (DT a) (NN yeast) (JJ two-hybrid) (NN strategy)) (S (VP (TO to) (VP (VB identify) (NP (NP (JJ other) (NNS proteins)) (SBAR (WHNP (WDT that)) (S (VP (VP (VBP interact) (PP (IN with))) (CC and) (VP (ADVP (RB potentially)) (VBP regulate) (NP (NN _PROT1_))))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD isolated) (NP (NP (DT a) (NN clone)) (VP (VBG encoding) (NP (NP (DT the) (JJ carboxyl-terminal) (NN half)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_)) (PP (IN of) (NP (JJ heterotrimeric) (NNS G-proteins)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (FW In) (FW vitro)) (, ,) (NP (VBN purified) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN GST) (NN fusion) (NN protein)) (VP (VBG encoding) (NP (NP (NN amino) (NNS acids) (CD 1-330)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (FW In) (FW vitro)) (, ,) (NP (VBN purified) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS subunits)) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN GST) (NN fusion) (NN protein)) (VP (VBG encoding) (NP (NP (NN amino) (NNS acids) (CD 1-330)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (FW In) (FW vitro)) (, ,) (NP (VBN purified) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NNS subunits)) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (DT a) (NN GST) (NN fusion) (NN protein)) (VP (VBG encoding) (NP (NP (NN amino) (NNS acids) (CD 1-330)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Binding) (NNS assays)) (PP (IN with) (NP (NP (NN truncation) (NNS mutants)) (PP (IN of) (NP (NN _PROT1_)))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (NN region)) (ADJP (JJ located) (PP (IN between) (NP (NN amino) (NNS acids) (CD 136) (CC and) (CD 239))))) (VP (VBZ is) (NP (NP (DT a) (JJ primary) (NN determinant)) (PP (IN for) (NP (NP (NN interaction)) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT2_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT2_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN _PROT1_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT2_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT2_) (NNS proteins)) (, ,) (NP (NP (NN _PROT_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT1_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN competition) (NNS experiments))) (, ,) (NP (NP (DT the) (NN carboxyl) (NN terminus)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN _PROT_)) (-RRB- -RRB-))))) (VP (VBD blocked) (NP (NP (DT the) (NN binding)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))) (PP (TO to) (NP (NN _PROT_)))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (JJ _PROT1_) (NNS proteins)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN 14-3-3))) (, ,)) (VP (VBD had) (NP (DT no) (NN effect)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Scatchard) (NN analysis)) (PP (IN of) (NP (NP (ADJP (FW in) (FW vitro)) (NN binding)) (PP (IN between) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))) (VP (VBD revealed) (NP (NP (DT an) (NN affinity)) (PP (IN of) (NP (NP (NN interaction)) (PRN (-LRB- -LRB-) (NP (NP (NN Kd)) (ADJP (JJ =) (NP (QP (CD 163) (CC +/-) (CD 36)) (NN nM)))) (-RRB- -RRB-)))) (, ,) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT that)) (VP (VBN seen) (PP (IN between) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN Kd) (JJ =) (CD 87) (CC +/-) (CD 24) (NN nM)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN formation)) (PP (IN of) (NP (JJ native) (JJ heterotrimeric) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NNS complexes))) (, ,) (SBAR (IN as) (S (VP (VBN measured) (PP (IN by) (NP (NP (NP (NN pertussis) (NN toxin)) (NN ADP-ribosylation)) (PP (IN of) (NP (NN G) (NN alpha)))))))) (, ,)) (VP (MD could) (VP (VB be) (VP (VBN disrupted) (PP (IN by) (NP (NP (VBG increasing) (NNS amounts)) (PP (IN of) (NP (NN _PROT2_))))) (, ,) (PP (IN with) (NP (NP (DT an) (NN EC50)) (PP (IN of) (NP (QP (RB approximately) (CD 200)) (NN nM))))) (, ,) (PP (IN in) (NP (NP (JJ close) (NN agreement)) (PP (IN with) (NP (DT the) (VBN estimated) (NN binding) (NN affinity))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ human) (JJ embryonic) (NN kidney) (JJ 293-T) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ epitope-tagged) (NN _PROT_) (NN _PROT_) (CD _PROT_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ human) (JJ embryonic) (NN kidney) (JJ 293-T) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ epitope-tagged) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS complexes)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (VP (VBD were) (VP (VBN isolated) (PP (IN from) (NP (NP (JJ human) (JJ embryonic) (NN kidney) (JJ 293-T) (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ epitope-tagged) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NP (DT a) (JJ human) (NN G1)) (CC and) (NP (NN S)) (NP (NN phase) (NN protein) (NN phosphatase))) (SBAR (WHNP (WDT that)) (S (VP (VBZ associates) (PP (IN with) (NP (NN _PROT2_))))))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD used) (NP (NP (DT the) (NN interaction) (NN trap)) (, ,) (NP (NP (DT a) (NN yeast) (JJ genetic) (NN selection)) (PP (IN for) (NP (NN interacting) (NNS proteins)))) (, ,)) (S (VP (TO to) (VP (VB isolate) (NP (NP (NP (JJ human) (JJ _PROT1_) (NN _PROT1_)) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN yeast))) (, ,) (NP (NN _PROT_)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NP (JJ cyclin-dependent) (NNS kinases)) (, ,) (PP (VBG including) (NP (NP (JJ human) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT1_)))) (, ,))) (CC but) (PP (RB not) (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN HeLa) (NNS cells))) (, ,) (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN expressed) (PP (IN at) (NP (DT the) (NN G1) (TO to) (NN S) (NN transition)))))) (, ,) (CC and) (S (NP (DT the) (NN protein)) (VP (VBZ forms) (NP (NP (JJ stable) (NNS complexes)) (PP (IN with) (NP (NN _PROT2_))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (JJ wild-type) (NN _PROT1_)))) (VP (VBZ delays) (NP (NN progression)) (PP (IN through) (NP (DT the) (NN cell) (NN cycle))) (PP (IN in) (NP (NP (NN yeast)) (CC and) (NP (NN HeLa) (NNS cells)))))) (: ;) (S (NP (NN delay)) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN on) (NP (NN _PROT2_) (NN phosphatase) (NN activity)))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT the) (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT the) (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN cDNA) (NN cloning)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (DT the) (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)))) (. .)))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (CD _PROT1_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (CD _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP have) (VP (VBN cloned) (NP (NP (NNS cDNAs)) (VP (VBG corresponding) (PP (TO to) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT2_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT1_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT1_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (RB Only) (JJ weak)) (NN _PROT_) (NN binding) (NN activity)) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (VP (VBN transfected) (PP (IN with) (NP (JJ only) (NN _PROT_))))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD resulted) (PP (IN in) (NP (JJ substantial) (NN binding) (NN activity))) (, ,) (PP (IN with) (NP (NP (DT a) (NN Kd)) (PP (IN of) (NP (QP (RB approximately) (CD 400)) (NN pM))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (DT both) (NNS chains)) (VP (VBP are) (NP (NP (JJ essential) (NNS components)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
+1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT1_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT2_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT1_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT1_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (SBAR (IN Whereas) (S (NP (NN _PROT_)) (VP (VBZ serves) (PP (IN as) (NP (NP (DT an) (JJ alternative) (NN accessory) (NN protein)) (PP (TO to) (NP (NP (DT the) (JJ common) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (PP (IN for) (NP (NN _PROT_) (NN signaling)))))))) (, ,) (NP (PRP it)) (VP (MD could) (RB not) (VP (VB replace) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN in) (S (VP (VBG allowing) (NP (VBN enhanced) (NN _PROT2_) (NN binding) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT2_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT2_))) (, ,) (NP (NN _PROT_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (NP (DT the) (JJ overall) (NN size)) (CC and) (NP (NN length))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (VP (VBP are) (ADJP (JJ similar)))) (, ,) (CC and) (S (PP (IN like) (NP (NN _PROT1_))) (, ,) (NP (NN _PROT2_)) (VP (VBZ is) (ADJP (JJ located) (PP (IN on) (NP (NN chromosome) (NN X))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ SREBP) (JJ transcriptional) (NN activity)) (VP (VBZ is) (VP (VBN mediated) (PP (IN through) (NP (NP (DT an) (NN interaction)) (PP (IN with) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (DT an) (JJ unbiased) (NN search)) (PP (IN for) (NP (NP (JJ potential) (NNS coactivators)) (PP (IN of) (NP (NN SREBP))))))) (, ,) (NP (PRP we)) (VP (VBD isolated) (NP (NP (DT a) (NN protein)) (PP (IN of) (NP (CD 265) (NN kD)))) (PP (IN from) (NP (NP (NN HeLa) (NNS cells)) (SBAR (WHNP (WDT that)) (S (ADVP (RB directly)) (VP (VBD bound) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Peptide) (NN sequencing)) (CC and) (NP (NN Western) (NN blot) (NN analysis))) (VP (VBD established) (SBAR (IN that) (S (NP (DT the) (JJ 265-kD) (NN protein)) (VP (VBD was) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (JJ _PROT2_) (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (DT a) (ADJP (RB recently) (VBN identified)) (JJ transcriptional) (NN coactivator)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ putative) (NN activation) (NN domain)) (PP (IN of) (NP (NN SREBP)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (JJ amino-terminal) (NNS domains)) (PP (IN of) (NP (NP (JJ recombinant) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (DT a) (JJ _PROT_) (NN protein)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ putative) (NN activation) (NN domain)) (PP (IN of) (NP (NN SREBP)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (JJ amino-terminal) (NNS domains)) (PP (IN of) (NP (NP (JJ recombinant) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PRN (-LRB- -LRB-) (NP (DT a) (JJ _PROT2_) (NN protein)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ putative) (NN activation) (NN domain)) (PP (IN of) (NP (NN SREBP)))) (VP (VBD was) (VP (VBN shown) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (JJ amino-terminal) (NNS domains)) (PP (IN of) (NP (NP (JJ recombinant) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PRN (-LRB- -LRB-) (NP (DT a) (JJ _PROT2_) (NN protein)) (-RRB- -RRB-)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Associations)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NNS proteins)))) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))) (. .)))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT2_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT1_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT1_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT1_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (VBG Using) (NP (DT the) (JJ human) (NN _PROT_) (NN protein)) (PP (IN as) (NP (NP (DT the) (`` ``) (NN bait) (NN '')) (PP (IN in) (NP (DT a) (NN yeast) (JJ two-hybrid) (NN system))))))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN identified) (NP (NP (DT a) (JJ human) (NN homolog)) (PP (IN of) (NP (NN yeast) (NN _PROT_))) (, ,) (VP (VBN designated) (S (NP (NN _PROT_)))) (, ,) (SBAR (WHNP (WDT that)) (S (VP (VBZ interacts) (PP (IN with) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NP (DT a) (JJ ubiquitin-like) (NN protein)) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS interactions)) (VP (VBP are) (ADJP (JJ _PROT1_)) (, ,) (SBAR (IN since) (S (NP (NP (DT another) (NN DNA) (JJ repair-related) (NN ubiquitin-conjugating) (NN enzyme)) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (DT these) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS interactions)) (VP (VBP are) (ADJP (JJ _PROT1_)) (, ,) (SBAR (IN since) (S (NP (NP (DT another) (NN DNA) (JJ repair-related) (NN ubiquitin-conjugating) (NN enzyme)) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (DT these) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS interactions)) (VP (VBP are) (ADJP (JJ _PROT_)) (, ,) (SBAR (IN since) (S (NP (NP (DT another) (NN DNA) (JJ repair-related) (NN ubiquitin-conjugating) (NN enzyme)) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,)) (VP (VBZ does) (RB not) (VP (VB interact) (PP (IN with) (NP (DT these) (NNS proteins))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT_) (POS 's)) (NN self-association) (NN region)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_) (POS 's)) (NN self-association) (NN region)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN interaction)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (NP (NN _PROT2_) (POS 's)) (NN self-association) (NN region)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NNS processes)) (, ,) (NP (NN cell) (NN cycle) (NN control)) (, ,) (NP (JJ _PROT2_) (NN pathway) (-LRB- -LRB-) (NNS s) (-RRB- -RRB-)) (, ,) (CC and) (NP (NN ubiquitination))) (VP (VBP interact) (PP (IN through) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NNS processes)) (, ,) (NP (NN cell) (NN cycle) (NN control)) (, ,) (NP (JJ _PROT_) (NN pathway) (-LRB- -LRB-) (NNS s) (-RRB- -RRB-)) (, ,) (CC and) (NP (NN ubiquitination))) (VP (VBP interact) (PP (IN through) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT_) (NNS processes)) (, ,) (NP (NN cell) (NN cycle) (NN control)) (, ,) (NP (JJ _PROT1_) (NN pathway) (-LRB- -LRB-) (NNS s) (-RRB- -RRB-)) (, ,) (CC and) (NP (NN ubiquitination))) (VP (VBP interact) (PP (IN through) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (ADVP (RB now)) (VP (VBP find) (SBAR (IN that) (S (NP (NN HIV-1)) (VP (VBZ begins) (NP (JJ reverse) (NN transcription)) (ADVP (RB much) (RBR more) (RB efficiently)) (PP (IN in) (NP (NP (NNS DCs)) (PP (IN than) (NP (NN T) (NNS cells))))) (, ,) (SBAR (RB even) (IN though) (S (NP (NN T) (NNS cells)) (VP (VBP have) (NP (NP (JJR higher) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN binding))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (IN with) (NP (NN _PROT_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (PP (IN with) (NP (NN _PROT2_) (NNS receptors))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT_)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (PP (IN with) (NP (NN _PROT2_) (NNS receptors))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NNS DCs)) (VP (VBP express) (NP (NP (RBR more) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)) (NP (NN mRNA)))) (PP (IN than) (NP (NN T) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ transcriptional) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ communicates) (PP (IN with) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_) (NN _PROT_) (CD _PROT_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ transcriptional) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ communicates) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (NN _PROT_) (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ transcriptional) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ communicates) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (CD _PROT2_)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (VP (VBZ transactivates) (NP (ADJP (ADJP (JJ viral)) (CC and) (ADJP (JJ cellular))) (NNS genes)) (PP (IN through) (NP (NP (DT a) (JJ wide) (NN variety)) (PP (IN of) (NP (NNS cis-elements))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (CD _PROT2_) (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT1_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN _PROT1_) (CD _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (PRP$ Our) (NN finding)) (PP (IN that) (S (NP (NN _PROT_)) (ADVP (RB directly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN _PROT_) (CD _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (JJ common) (NN subunit)) (PP (IN of) (NP (NN RNA) (NNS polymerases)))) (, ,))))))) (VP (VBZ implies) (SBAR (IN that) (S (NP (NN _PROT2_)) (ADVP (RB directly)) (VP (VBZ modulates) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (NN RNA) (NN polymerase)) (PRN (-LRB- -LRB-) (NP (NP (NP (NNP Cheong) (, ,) (NNP J.) (NNP H.)) (, ,) (NP (NNP Yi) (, ,) (NNP M.)) (, ,) (NP (NNP Lin) (, ,) (NNP Y.)) (, ,) (CC and) (NP (NNP Murakami) (, ,) (NNP S)) (. .)) (PRN (-LRB- -LRB-) (NP (CD 1995)) (-RRB- -RRB-)) (NP (NNP EMBO) (NNP J.) (CD 14) (, ,) (CD 142-150))) (-RRB- -RRB-)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (DT this) (NN context))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP interact) (PP (IN with) (NP (JJ other) (JJ general) (NN transcription) (NNS factors))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (ADVP (RB specifically)) (VP (VBD bound) (PP (TO to) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))) (ADVP (FW in) (FW vitro))) (, ,) (SBAR (WHNP (NP (DT both)) (WHPP (IN of) (WHNP (WDT which)))) (S (VP (VBD were) (VP (VBN detected) (PP (IN by) (NP (CC either) (NP (JJ far-Western) (NN blotting)) (CC or) (NP (DT the) (NN glutathione) (NN S-transferase-resin) (JJ pull-down) (NN assay))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Delineation)) (PP (IN of) (NP (NP (DT the) (NN binding) (NNS regions)) (PP (IN of) (NP (DT these) (CD three) (NNS proteins)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (NP (DT each))) (VP (VBZ has) (NP (NP (CD two) (NN binding) (NNS regions)) (PP (IN for) (NP (DT the) (JJ other) (CD two) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Delineation)) (PP (IN of) (NP (NP (DT the) (NN binding) (NNS regions)) (PP (IN of) (NP (DT these) (CD three) (NNS proteins)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (NP (DT each))) (VP (VBZ has) (NP (NP (CD two) (NN binding) (NNS regions)) (PP (IN for) (NP (DT the) (JJ other) (CD two) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Delineation)) (PP (IN of) (NP (NP (DT the) (NN binding) (NNS regions)) (PP (IN of) (NP (DT these) (CD three) (NNS proteins)))))) (VP (VBD revealed) (SBAR (IN that) (S (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (NP (DT each))) (VP (VBZ has) (NP (NP (CD two) (NN binding) (NNS regions)) (PP (IN for) (NP (DT the) (JJ other) (CD two) (NNS proteins))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT2_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT1_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT2_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT1_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT2_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT1_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT1_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT Some) (NN _PROT_) (NN substitution) (NNS mutants)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD had) (ADJP (RB severely) (JJ impaired) (PP (VBG transacting) (NP (NN activity))))))) (, ,)) (VP (VBD exhibited) (NP (VBN reduced) (NN binding) (NN affinity)) (PP (IN with) (NP (CC either) (NP (NN _PROT_)) (CC or) (NP (NN _PROT_)))) (PP (IN in) (NP (DT a) (ADJP (RB mutually) (JJ exclusive)) (NN manner))) (, ,) (S (VP (VBG suggesting) (SBAR (IN that) (S (NP (NN _PROT_) (NN transactivation)) (VP (VBZ requires) (NP (NP (DT the) (NNS interactions)) (PP (IN of) (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT2_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT1_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT1_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBD indicated) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ is) (NP (NP (DT a) (JJ novel) (NN virus) (NN modulator)) (SBAR (WHNP (WDT that)) (S (VP (VBZ facilitates) (NP (JJ transcriptional) (NN initiation)) (PP (IN by) (S (VP (VBG stabilizing) (NP (NP (DT the) (NN association)) (PP (IN between) (NP (NP (NN RNA) (NN polymerase)) (CC and) (NP (NN _PROT_))))) (PP (IN through) (NP (NP (NN communication)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT A) (JJ new) (JJ cytokine-receptor) (NN binding) (NN mode)) (VP (VBN revealed) (PP (IN by) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN of) (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT2_))) (PP (IN with) (NP (DT an) (NN antagonist))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Inflammation)) (, ,) (ADVP (RB regardless) (PP (IN of) (SBAR (IN whether) (S (NP (PRP it)) (VP (VBZ is) (VP (VBD provoked) (PP (PP (IN by) (NP (NN infection))) (CC or) (PP (IN by) (NP (NN tissue) (NN damage)))))))))) (, ,) (VP (VBZ starts) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (NNS macrophages)) (SBAR (WHNP (WDT which)) (S (VP (VBP initiate) (NP (NP (DT a) (NN cascade)) (PP (IN of) (NP (JJ inflammatory) (NNS responses)))) (PP (IN by) (S (VP (VBG producing) (NP (NP (DT the) (NNS cytokines)) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 1)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Inflammation)) (, ,) (ADVP (RB regardless) (PP (IN of) (SBAR (IN whether) (S (NP (PRP it)) (VP (VBZ is) (VP (VBD provoked) (PP (PP (IN by) (NP (NN infection))) (CC or) (PP (IN by) (NP (NN tissue) (NN damage)))))))))) (, ,) (VP (VBZ starts) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (NNS macrophages)) (SBAR (WHNP (WDT which)) (S (VP (VBP initiate) (NP (NP (DT a) (NN cascade)) (PP (IN of) (NP (JJ inflammatory) (NNS responses)))) (PP (IN by) (S (VP (VBG producing) (NP (NP (DT the) (NNS cytokines)) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 1)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN Inflammation)) (, ,) (ADVP (RB regardless) (PP (IN of) (SBAR (IN whether) (S (NP (PRP it)) (VP (VBZ is) (VP (VBD provoked) (PP (PP (IN by) (NP (NN infection))) (CC or) (PP (IN by) (NP (NN tissue) (NN damage)))))))))) (, ,) (VP (VBZ starts) (PP (IN with) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NP (NNS macrophages)) (SBAR (WHNP (WDT which)) (S (VP (VBP initiate) (NP (NP (DT a) (NN cascade)) (PP (IN of) (NP (JJ inflammatory) (NNS responses)))) (PP (IN by) (S (VP (VBG producing) (NP (NP (DT the) (NNS cytokines)) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 1)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT2_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (JJ _PROT_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_AND_PROT2_) (NN _PROT2_)) (NP (NNP _PROT_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_) (NN _PROT_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (CD Three) (ADJP (RB naturally) (VBG occurring)) (NNS ligands)) (PP (IN for) (NP (DT the) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN _PROT_)) (-RRB- -RRB-)))))) (VP (VBP exist) (: :) (NP (DT the) (NNS agonists) (NP (NP (NN _PROT_)) (CC and) (NP (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (JJ _PROT1_) (NN _PROT1_)) (NP (NNP _PROT2_))) (PRN (-LRB- -LRB-) (NP (NN ref.) (CD 2)) (-RRB- -RRB-))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN at) (NP (NP (CD 2.7) (DT A) (NN resolution)) (PP (IN of) (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NN part)) (PP (IN of) (NP (NP (JJ _PROT2_) (NN _PROT1_AND_PROT2_)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN at) (NP (NP (CD 2.7) (DT A) (NN resolution)) (PP (IN of) (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NN part)) (PP (IN of) (NP (NP (JJ _PROT_) (NN _PROT1_)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP describe) (NP (NP (DT the) (NN crystal) (NN structure)) (PP (IN at) (NP (NP (CD 2.7) (DT A) (NN resolution)) (PP (IN of) (NP (NP (DT the) (JJ soluble) (JJ extracellular) (NN part)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT1_)) (VP (VBN complexed) (PP (IN with) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ important) (PP (IN for) (NP (NP (JJ biological) (NN function)) (PP (IN in) (NP (NP (NN _PROT1_)) (, ,) (NP (DT the) (`` ') (NN receptor) (NN trigger) (NN site) ('' '))))))))))) (VP (VBZ is) (RB not) (PP (IN in) (NP (NP (JJ direct) (NN contact)) (PP (IN with) (NP (NP (DT the) (NN receptor)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN complex))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN interaction)) (PP (IN between) (NP (DT the) (NN bHLHZip) (NN _PROT1_) (CC and) (NN bZip) (NN _PROT2_) (NNS proteins)))) (VP (VBZ results) (PP (IN in) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NN _PROT_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN interaction)) (PP (IN between) (NP (DT the) (NN bHLHZip) (NN _PROT1_) (CC and) (NN bZip) (NN _PROT_) (NNS proteins)))) (VP (VBZ results) (PP (IN in) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Cross-family) (NN interaction)) (PP (IN between) (NP (DT the) (NN bHLHZip) (NN _PROT_) (CC and) (NN bZip) (NN _PROT1_) (NNS proteins)))) (VP (VBZ results) (PP (IN in) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NN _PROT2_) (NN activity))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (ADVP (RB further)) (VP (VB examine) (NP (NP (DT the) (NN function)) (PP (IN of) (NP (NP (DT the) (NN bHLHZip) (NN protein)) (, ,) (NP (NN _PROT1_)))))))) (, ,) (NP (PRP we)) (VP (VBD screened) (PP (IN for) (NP (NP (JJ cellular) (NNS proteins)) (SBAR (WHNP (WDT which)) (S (VP (MD could) (ADVP (RB directly)) (VP (VB interact) (PP (IN with) (NP (NP (NN _PROT2_)) (VP (VBG using) (NP (DT the) (NN yeast) (JJ two-hybrid) (NN system))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN bZip) (NN protein)) (, ,) (NP (NN _PROT1_)) (, ,)) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (ADVP (RB efficiently)) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT2_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT1_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_)) (ADVP (RB specifically)) (VP (VBZ interacts) (PP (PP (IN with) (NP (NN _PROT_))) (CC but) (RB not) (PP (IN with) (NP (NP (JJ other) (ADJP (RB closely) (JJ related)) (NN family) (NNS members)) (, ,) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_))) (, ,))) (CC or) (PP (IN with) (NP (NN _PROT2_)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (CC Both) (NP (DT the) (NN bHLHZip)) (CC and) (NP (NP (DT the) (JJ N-terminal) (NNS regions)) (PP (IN of) (NP (NN _PROT1_))))) (VP (VBP are) (VP (VBN required) (PP (IN for) (NP (NP (JJ efficient) (NN interaction)) (PP (IN with) (NP (NN _PROT2_)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (FW In) (FW vivo)) (NN association)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBZ has) (VP (VBN been) (VP (VBN demonstrated) (PP (IN by) (NP (NN co-immunoprecipitation))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Expression)) (PP (IN of) (NP (JJ exogenous) (NN _PROT1_)))) (VP (VBD led) (PP (TO to) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (JJ _PROT2_) (NN transcription)) (PP (IN in) (NP (NN F9) (NNS cells))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (JJ exogenous) (NN _PROT1_)))) (VP (VBD restored) (NP (DT the) (NN _PROT2_) (NN activity)) (PP (IN in) (NP (DT a) (JJ dose-dependent) (NN manner))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS data)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (ADVP (ADVP (RB physically)) (CC and) (ADVP (RB functionally))) (VP (VBP interact) (S (VP (VBG demonstrating) (SBAR (IN that) (S (NP (NN cross-talk)) (VP (VBZ occurs) (PP (IN between) (NP (NP (NNS factors)) (PP (IN of) (NP (ADJP (RB distantly) (JJ related)) (NN transcription) (NNS families))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN between) (NP (NP (NN _PROT1_) (NN protein)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN DNA) (NN damage))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (DT The) (NN gene)) (VP (VBN mutated) (PP (IN in) (NP (NP (DT the) (JJ autosomal) (JJ recessive) (NN disorder)) (NP (NP (NN ataxia) (NN telangiectasia)) (PRN (-LRB- -LRB-) (NP (NN AT)) (-RRB- -RRB-))))))) (, ,) (VP (VBN designated) (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (PP (IN for) (ADJP (`` ') (NN _PROT2_) (JJ _PROT2_) ('' '))) (-RRB- -RRB-))))) (, ,)) (VP (VBZ is) (NP (NP (DT a) (NN member)) (PP (IN of) (NP (NP (DT a) (NN family)) (PP (IN of) (NP (NP (JJ phosphatidylinositol-3-kinase-like) (NNS enzymes)) (SBAR (WHNP (WDT that)) (S (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (NP (JJ cell-cycle) (NN control)) (, ,) (NP (JJ meiotic) (NN recombination)) (, ,) (NP (NN telomere) (NN length) (NN monitoring)) (CC and) (NP (NN DNA-damage) (NN response))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (NNS cells)) (VP (VBG lacking) (NP (DT the) (NP (NN protein) (NN tyrosine) (NN kinase)) (NN _PROT1_)))) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ defective) (PP (IN in) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (MD might) (VP (VB interact) (PP (IN with) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN radiation) (NN damage)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (NNS cells)) (VP (VBG lacking) (NP (DT the) (NP (NN protein) (NN tyrosine) (NN kinase)) (NN _PROT1_)))) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ defective) (PP (IN in) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD might) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN radiation) (NN damage)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (NNS cells)) (VP (VBG lacking) (NP (DT the) (NP (NN protein) (NN tyrosine) (NN kinase)) (NN _PROT_)))) (VP (VBP are) (ADVP (RB also)) (ADJP (JJ defective) (PP (IN in) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))) (, ,) (NP (PRP we)) (VP (VBD investigated) (NP (DT the) (NN possibility) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD might) (VP (VB interact) (PP (IN with) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NN radiation) (NN damage)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (NP (NN _PROT2_)) (ADVP (RB constitutively)) (PP (PP (IN in) (NP (NN control) (NNS cells))) (CC but) (PP (RB not) (IN in) (NP (NN AT) (NNS cells))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (DT the) (NN SH3) (NN domain)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ interacts) (PP (IN with) (NP (NP (NP (DT a) (NN DPAPNPPHFP) (NN motif)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 1,373-1,382))) (-RRB- -RRB-))) (PP (IN of) (NP (NN _PROT2_)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS findings)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NN _PROT1_)) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN by) (NP (NN DNA) (NN damage)))))))) (CC and) (S (NP (DT this) (NN interaction)) (VP (MD may) (PP (IN in) (NP (NN part))) (VP (VB mediate) (NP (JJ radiation-induced) (NN G1) (NN arrest))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_) (NN _PROT2_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT2_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT2_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT A) (NN region)) (PP (IN of) (NP (NP (DT the) (NN beta) (NN subunit)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN _PROT_) (NN _PROT_)) (ADJP (JJ different) (PP (IN from) (NP (NN box) (CD 1))))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT1_)))) (CC and) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT2_) (NN pathway))) (CC and) (VP (VB induce) (NP (DT an) (JJ antiviral) (NN state)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT2_)) (-RRB- _PROT_))) (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_AND_PROT2_) (NN _PROT1_AND_PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- _PROT2_) (NP (NN _PROT1_AND_PROT2_)) (-RRB- _PROT2_))) (NN _PROT2_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT1_)) (-RRB- _PROT_))) (NN _PROT_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Coexpression)) (PP (IN of) (NP (NP (DT the) (NN alpha) (CC and) (NN betaL) (NNS subunits)) (PP (IN of) (NP (DT the) (NP (NP (JJ human) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))))) (VP (VBZ is) (VP (VBN required) (PP (IN for) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (DT an) (JJ antiviral) (NN state))) (PP (IN by) (NP (JJ human) (NN _PROT2_)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS results)) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NP (NP (DT the) (JJ first) (CD 82) (NN amino) (NNS acids)) (PRN (-LRB- -LRB-) (NP (NN AAs)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN AAs) (CD 265-346)) (-RRB- -RRB-))) (PP (IN of) (NP (NP (DT the) (JJ cytoplasmic) (NN domain)) (PP (IN of) (NP (DT the) (JJ betaL) (NN chain)))))) (VP (VBP are) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VP (VB activate) (NP (DT the) (NN _PROT1_) (NN pathway))) (CC and) (VP (VB trigger) (NP (DT an) (JJ antiviral) (NN state)) (PP (IN after) (NP (NP (NN _PROT2_) (NN binding)) (PP (TO to) (NP (DT the) (NN receptor))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT This) (NN region)) (PP (IN of) (NP (DT the) (JJ betaL) (NN chain))) (, ,) (VP (VBN required) (PP (IN for) (NP (NP (NN _PROT1_) (NN binding)) (CC and) (NP (NN activation))))) (, ,)) (VP (VBZ contains) (NP (NP (DT the) (NN Box) (CD 1) (NN motif)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ important) (PP (IN for) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (DT some) (NN cytokine) (NNS receptors))) (PP (IN with) (NP (NN _PROT2_) (NNS kinases)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Interaction)) (PP (IN between) (NP (NP (NN cell) (NN cycle) (NN regulator)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))))) (VP (VBZ mediates) (NP (NP (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN gene) (NN transcription)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_AND_PROT2_) (NN family)) (PP (IN of) (NP (NN transcription) (NNS factors)))) (VP (VBZ is) (NP (NP (CD one)) (PP (IN of) (NP (NP (DT the) (JJ main) (NNS targets)) (PP (IN of) (NP (NP (NNS cytokines)) (CC and) (NP (JJ other) (NNS agents)))))) (SBAR (WHNP (WDT that)) (S (VP (VBP induce) (NP (NN HIV-1) (NN gene) (NN expression)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT Some)) (PP (IN of) (NP (DT these) (JJ extracellular) (NNS stimuli)))) (VP (VP (VB arrest) (NP (NP (NNS cells)) (PP (IN in) (NP (NP (DT the) (NN G1) (NN phase)) (PP (IN of) (NP (DT the) (JJ mitotic) (NN division) (NN cycle))))))) (CC and) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN tumor) (NN suppressor) (NP (NN protein) (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (NN partner)) (NP (NN _PROT2_))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT_) (NN subunit) (, ,) (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN subunit) (, ,) (NN _PROT_))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT_) (NN subunit) (, ,) (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN subunit) (, ,) (NN _PROT_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT1_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT_) (NN subunit) (, ,) (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Here)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (MD may) (VP (VB regulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the) (NN HIV-1) (JJ long) (JJ terminal) (NN repeat)))) (PP (IN through) (NP (PRP$ its) (NN ability) (S (VP (VP (TO to) (VP (VB bind) (NP (NP (NNS sequences)) (PP (IN in) (NP (DT the) (NN _PROT_) (NN enhancer) (NN region)))))) (CC and) (VP (TO to) (VP (VB interact) (PP (IN with) (NP (DT the) (NN _PROT1_) (NN subunit) (, ,) (NN _PROT2_))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Gel) (NN retardation)) (CC and) (NP (NN methylation) (NN interference))) (NNS assays)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADJP (JJ able) (S (VP (TO to) (VP (VB bind) (ADVP (RB specifically)) (PP (TO to) (NP (NP (DT a) (NN site)) (ADJP (JJ embedded) (PP (IN within) (NP (DT the) (CD two) (NN _PROT2_) (NNS elements))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Gel) (NN retardation/immunoblot) (NN analysis)) (VP (VBG using) (NP (VBN purified) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS homodimers)))) (VP (VBZ reveals) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NNS complexes)) (VP (VBG containing) (NP (DT both) (NNS proteins)))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Affinity) (NN chromatography)) (CC and) (NP (NN co-immunoprecipitation) (NNS assays))) (VP (VBP provide) (NP (NP (NN evidence)) (PP (IN for) (NP (NP (JJ direct) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (PRP$ their) (NN DNA) (NN target) (NNS sequences)))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (ADJP (FW In) (FW vitro)) (NN transcription) (NN assay)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ represses) (NP (NN _PROT2_) (JJ mediated) (NN transcription)) (PP (IN in) (NP (DT a) (JJ cell-free) (NN system)))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NNS studies)) (PP (IN in) (NP (NN Jurkat) (NN T) (JJ lymphocytic) (NNS cells)))) (VP (VBP point) (PP (TO to) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (CC both) (DT the) (NN _PROT1_) (CC and) (NN _PROT2_) (NN binding) (NNS sites))) (PP (IN in) (NP (NP (NN _PROT_) (JJ mediated) (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN promoter))))))) (, ,) (ADVP (FW in) (FW vivo)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NNS studies)) (PP (IN in) (NP (NN Jurkat) (NN T) (JJ lymphocytic) (NNS cells)))) (VP (VBP point) (PP (TO to) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (CC both) (DT the) (NN _PROT1_) (CC and) (NN _PROT_) (NN binding) (NNS sites))) (PP (IN in) (NP (NP (NN _PROT2_) (JJ mediated) (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN promoter))))))) (, ,) (ADVP (FW in) (FW vivo)))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Functional) (NNS studies)) (PP (IN in) (NP (NN Jurkat) (NN T) (JJ lymphocytic) (NNS cells)))) (VP (VBP point) (PP (TO to) (NP (NP (DT the) (NN importance)) (PP (IN of) (NP (CC both) (DT the) (NN _PROT_) (CC and) (NN _PROT1_) (NN binding) (NNS sites))) (PP (IN in) (NP (NP (NN _PROT2_) (JJ mediated) (NN repression)) (PP (IN of) (NP (NN HIV-1) (NN promoter))))))) (, ,) (ADVP (FW in) (FW vivo)))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NNS results)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activity)) (VP (MD may) (VP (VB be) (VP (VBN regulated) (PP (IN by) (NP (NP (PRP$ its) (NN interaction)) (PP (IN with) (NP (NP (DT the) (NN cell) (NN cycle) (JJ regulatory) (NN protein)) (, ,) (NP (NN _PROT2_))))))))))))) (. .))) |ET|
