-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT2_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT2_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT2_)) (CC and) (NP (JJ total) (NN _PROT_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN SP) (NNS ewes)) (ADVP (RB also)) (VP (VBD had) (NP (NP (JJR greater) (NN incorporation)) (PP (IN of) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol))) (PP (IN into) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +3449) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.01))) (-RRB- -RRB-))) (CC and) (NP (NP (NP (JJ total) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD +760) (NN %)) (, ,) (NP (NP (NN p)) (QP (JJR less) (IN than) (CD 0.08))) (-RRB- -RRB-)))))) (, ,) (PP (IN in) (NN response) (TO to) (NP (NN _PROT_))) (, ,) (SBAR (IN than) (SINV (VBD did) (NP (NP (NP (NN oCSP) (NNS ewes)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD +553) (CC and) (CD +168)) (NN %)) (PP (IN for) (NP (NP (NN _PROT1_)) (CC and) (NP (JJ total) (NN _PROT2_))))) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-))) (PP (IN in) (NP (NP (NN endometrium)) (VP (VBN collected) (PP (IN at) (NP (NN ovariectomy/hysterectomy))) (PP (IN on) (NP (NN Day) (CD 16)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN oTP-1)) (VP (VP (MD may) (VP (VB prevent) (NP (NN luteolysis)) (PP (IN by) (S (VP (VBG inhibiting) (NP (NP (NN development)) (PP (IN of) (NP (NP (JJ endometrial) (NN responsiveness)) (PP (TO to) (NP (NN _PROT1_))))))))))) (CC and) (, ,) (ADVP (RB therefore)) (, ,) (VP (VB reduce) (NP (NP (JJ _PROT2_) (NN synthesis)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN PGF2) (NN alpha)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN oTP-1)) (VP (VP (MD may) (VP (VB prevent) (NP (NN luteolysis)) (PP (IN by) (S (VP (VBG inhibiting) (NP (NP (NN development)) (PP (IN of) (NP (NP (JJ endometrial) (NN responsiveness)) (PP (TO to) (NP (NN _PROT1_))))))))))) (CC and) (, ,) (ADVP (RB therefore)) (, ,) (VP (VB reduce) (NP (NP (JJ _PROT_) (NN synthesis)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN PGF2) (NN alpha)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN oTP-1)) (VP (VP (MD may) (VP (VB prevent) (NP (NN luteolysis)) (PP (IN by) (S (VP (VBG inhibiting) (NP (NP (NN development)) (PP (IN of) (NP (NP (JJ endometrial) (NN responsiveness)) (PP (TO to) (NP (NN _PROT_))))))))))) (CC and) (, ,) (ADVP (RB therefore)) (, ,) (VP (VB reduce) (NP (NP (JJ _PROT1_) (NN synthesis)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN PGF2) (NN alpha)))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (NP (NP (NN SGR)) (CC and) (NP (NN RGR)))) (ADVP (RB also)) (VP (VBD had) (NP (JJ different) (JJ endocrine) (NNS profiles)) (PP (PP (IN with)) (, ,) (PP (IN for) (NP (NN example)))) (, ,) (ADVP (RB twice)) (PP (IN as) (NP (NP (JJ high) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.01)) (-RRB- -RRB-)))))) (CC and) (S (NP (NP (NP (NN _PROT2_) (NNS levels)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.01)) (-RRB- -RRB-))) (PP (IN in) (NP (NN RGR)))) (VP (VBN compared) (PP (TO to) (NP (DT the) (NN SGR))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT This) (NN action)) (PP (IN of) (NP (NN _PROT1_) (CD 25-35)))) (VP (VBZ is) (RB not) (VP (VBN altered) (PP (IN by) (NP (NP (NN pretreatment)) (PP (PP (IN with) (NP (NP (DT the) (NN calcium) (NN channel) (NNS blockers)) (NP (NP (NN nifedipine)) (CC or) (NP (NN cobalt))))) (, ,) (PP (IN with) (NP (NP (NP (DT the) (NN depleter)) (PP (IN of) (NP (JJ intracellular) (NN calcium) (NNS stores)))) (NP (JJ cyclopiazonic) (NN acid)))) (, ,) (CC or) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN inhibitor) (NN neomycin)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP support) (NP (DT the) (NN concept) (SBAR (IN that) (S (NP (NP (DT the) (JJ mitochondrial) (NN metabolism)) (PP (IN of) (NP (JJ nutrient) (NNS molecules)))) (VP (VBZ is) (NP (NP (DT an) (NN event)) (ADJP (JJ sufficient) (S (VP (VP (TO to) (ADVP (RB acutely)) (VP (VB augment) (NP (NP (NN _PROT1_) (NN release)) (PP (IN from) (NP (DT the) (NN beta) (NN cell)))))) (, ,) (VP (TO to) (VP (VB increase) (NP (NN _PROT2_) (JJ _PROT2_) (NN phosphoinositide) (NN hydrolysis)))) (, ,) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (JJ time-dependent) (NN potentiation)) (PP (IN of) (NP (NN _PROT_) (NN secretion))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP support) (NP (DT the) (NN concept) (SBAR (IN that) (S (NP (NP (DT the) (JJ mitochondrial) (NN metabolism)) (PP (IN of) (NP (JJ nutrient) (NNS molecules)))) (VP (VBZ is) (NP (NP (DT an) (NN event)) (ADJP (JJ sufficient) (S (VP (VP (TO to) (ADVP (RB acutely)) (VP (VB augment) (NP (NP (NN _PROT1_) (NN release)) (PP (IN from) (NP (DT the) (NN beta) (NN cell)))))) (, ,) (VP (TO to) (VP (VB increase) (NP (NN _PROT_) (JJ _PROT_) (NN phosphoinositide) (NN hydrolysis)))) (, ,) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (JJ time-dependent) (NN potentiation)) (PP (IN of) (NP (NN _PROT2_) (NN secretion))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP support) (NP (DT the) (NN concept) (SBAR (IN that) (S (NP (NP (DT the) (JJ mitochondrial) (NN metabolism)) (PP (IN of) (NP (JJ nutrient) (NNS molecules)))) (VP (VBZ is) (NP (NP (DT an) (NN event)) (ADJP (JJ sufficient) (S (VP (VP (TO to) (ADVP (RB acutely)) (VP (VB augment) (NP (NP (NN _PROT_) (NN release)) (PP (IN from) (NP (DT the) (NN beta) (NN cell)))))) (, ,) (VP (TO to) (VP (VB increase) (NP (NN _PROT1_) (JJ _PROT1_) (NN phosphoinositide) (NN hydrolysis)))) (, ,) (CC and) (VP (TO to) (VP (VB induce) (NP (NP (JJ time-dependent) (NN potentiation)) (PP (IN of) (NP (NN _PROT2_) (NN secretion))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Signal) (NN transduction)) (PP (IN in) (NP (JJ pancreatic) (NNS beta-cells)))) (: :) (NP (NP (NN Regulation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))) (PP (IN by) (NP (NP (NN information) (NN flow)) (PP (IN in) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN kinase) (NN C) (NN pathway))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (JJ glucose-induced) (NN _PROT1_) (NN secretion)))) (VP (VBZ is) (ADJP (JJ dependent) (PP (IN upon) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN information) (NN flow))) (PP (IN in) (NP (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NN /protein) (NN kinase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN signal) (NN transduction) (NN system))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NN rat) (NN islet)) (VP (VBP are) (VP (VBN cultured) (PP (IN for) (NP (JJ short) (NNS periods))))))) (, ,) (NP (NP (DT the) (NP (NN content)) (CC and) (NP (NN activation))) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NP (NN response)) (PP (TO to) (NP (NN glucose) (NNS decreases)))) (CC and) (NP (NP (DT this) (JJ biochemical) (NN defect)) (PP (IN in) (NP (NN signal) (NN transduction))))))) (VP (VBZ is) (VP (VBN paralleled) (PP (IN by) (NP (NP (JJ significant) (NNS reductions)) (PP (IN in) (NP (JJ glucose-induced) (NN _PROT2_) (NN secretion))))))))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Biphasic) (NN _PROT1_) (NN secretion)) (VP (MD can) (VP (VB be) (VP (VBN evoked))))) (CC and) (S (NP (JJ time-dependent) (NN potentiation)) (VP (MD can) (VP (VB be) (VP (VBN induced) (PP (IN in) (NP (NN mouse) (NNS islets))) (PP (IN by) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT an) (NN agonist)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (NP (DT an) (NN isozyme)) (PP (IN of) (NP (NN _PROT2_))) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN activated) (PP (IN by) (NP (NN glucose)))))))))))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN taken) (PP (IN in) (NP (PRP$ their) (NN entirety)))))) (, ,) (S (NP (DT the) (JJ experimental) (NN evidence)) (VP (VBZ suggests) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (NP (NP (DT an) (JJ essential) (NN component)) (PP (IN in) (NP (NP (DT the) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (NN _PROT2_) (NN secretion))))))))) (CC and) (SBAR (IN that) (S (NP (NP (VBN disordered) (NN activation)) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ culminates) (PP (IN in) (NP (VBN disordered) (NN _PROT_) (NN release))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN taken) (PP (IN in) (NP (PRP$ their) (NN entirety)))))) (, ,) (S (NP (DT the) (JJ experimental) (NN evidence)) (VP (VBZ suggests) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ is) (NP (NP (DT an) (JJ essential) (NN component)) (PP (IN in) (NP (NP (DT the) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (NN _PROT_) (NN secretion))))))))) (CC and) (SBAR (IN that) (S (NP (NP (VBN disordered) (NN activation)) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ culminates) (PP (IN in) (NP (VBN disordered) (NN _PROT2_) (NN release))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN taken) (PP (IN in) (NP (PRP$ their) (NN entirety)))))) (, ,) (S (NP (DT the) (JJ experimental) (NN evidence)) (VP (VBZ suggests) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBZ is) (NP (NP (DT an) (JJ essential) (NN component)) (PP (IN in) (NP (NP (DT the) (JJ physiologic) (NN regulation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))))))))) (CC and) (SBAR (IN that) (S (NP (NP (VBN disordered) (NN activation)) (PP (IN of) (NP (DT the) (NN enzyme)))) (VP (VBZ culminates) (PP (IN in) (NP (VBN disordered) (NN _PROT2_) (NN release))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Cellular) (NN preincubation)) (PP (IN with) (NP (NP (NP (ADJP (CD 200) (NN microg/ml)) (NNS antibodies)) (PP (IN against) (NP (NP (DT the) (NN inositolphosphoglycan) (-LRB- -LRB-) (NN IPG) (-RRB- -RRB-) (NN moiety)) (PP (IN of) (NP (DT the) (NN GPI-anchor))))) (PRN (-LRB- -LRB-) (NP (NP (NN Ab)) (PRN (-LRB- -LRB-) (NP (NN IPG)) (-RRB- -RRB-))) (-RRB- -RRB-)) (, ,)) (CC or) (NP (NP (NN depletion)) (PP (IN in) (NP (JJ GPI-anchored) (NNS proteins))) (PP (IN by) (NP (NP (JJ cellular) (NN pretreatment)) (PP (IN with) (NP (NP (ADJP (CD 0.5) (NN U/ml)) (NN _PROT1_)) (, ,) (NP (NP (CD 1) (NN mM) (NN _PROT2_)) (CC and) (NP (CD 2) (NN HU/ml) (JJ streptolysin-O))) (, ,) (CC or) (NP (NP (NN depletion)) (PP (IN in) (NP (NN membrane) (NN cholesterol) (NN content))) (PP (IN by) (NP (NP (NP (NN filipin)) (PRN (-LRB- -LRB-) (NP (CD 5) (NN microg/ml)) (-RRB- -RRB-))) (, ,) (NP (NP (NN digitonin)) (PRN (-LRB- -LRB-) (NP (CD 5) (NN microg/ml)) (-RRB- -RRB-))) (CC and) (NP (NP (NN cholesterol) (NN oxidase)) (PRN (-LRB- -LRB-) (NP (CD 0.5) (NN U/ml)) (-RRB- -RRB-)))))))))))))) (VP (VBZ decreases) (NP (DT the) (NN HDL3-signal)) (, ,) (S (VP (VBG suggesting) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (DT a) (JJ lipolytic) (NN cleavage)) (PP (IN of) (NP (JJ GPI-anchored) (NNS proteins))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT1_) (NN beta) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 25-35)) (-RRB- -RRB-))) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (NN LA-N-2) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT This) (NN _PROT1_) (NN _PROT1_) (NN stimulation)) (PP (IN by) (NP (JJ _PROT2_) (NN beta) (NN protein)))) (VP (VBD appeared) (S (VP (TO to) (VP (VB be) (NP (NN pertussis) (NN toxin) (JJ sensitive)))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (ADJP (JJ possible)) (SBAR (IN that) (S (NP (NP (DT this) (NN _PROT1_) (NN _PROT1_) (NN stimulation)) (PP (IN by) (NP (JJ _PROT2_) (NN beta) (NN protein)))) (VP (VBZ is) (NP (DT a) (JJ receptor-mediated) (NN process)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (VBD was) (ADJP (JJ absent) (PP (IN from) (NP (NP (NN LA-N-2) (NNS cells)) (VP (ADVP (RB previously)) (VBN treated) (PP (IN with) (NP (NP (NN norepinephrine)) (, ,) (NP (NP (JJ trans-1-amino-1,3-cyclopentanedicarboxylic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN t-ACPD)) (-RRB- -RRB-))) (, ,) (NP (NN bombesin)) (, ,) (CC or) (NP (NN _PROT_) (NN beta) (NN peptide))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_)))) (VP (VBD was) (ADJP (JJ absent) (PP (IN from) (NP (NP (NN LA-N-2) (NNS cells)) (VP (ADVP (RB previously)) (VBN treated) (PP (IN with) (NP (NP (NN norepinephrine)) (, ,) (NP (NP (JJ trans-1-amino-1,3-cyclopentanedicarboxylic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN t-ACPD)) (-RRB- -RRB-))) (, ,) (NP (NN bombesin)) (, ,) (CC or) (NP (NN _PROT2_) (NN beta) (NN peptide))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (VP (VBD was) (ADJP (JJ absent) (PP (IN from) (NP (NP (NN LA-N-2) (NNS cells)) (VP (ADVP (RB previously)) (VBN treated) (PP (IN with) (NP (NP (NN norepinephrine)) (, ,) (NP (NP (JJ trans-1-amino-1,3-cyclopentanedicarboxylic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN t-ACPD)) (-RRB- -RRB-))) (, ,) (NP (NN bombesin)) (, ,) (CC or) (NP (NN _PROT2_) (NN beta) (NN peptide))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (VP (VBN suggested) (SBAR (IN that) (S (NP (NP (DT this) (VBN observed) (NN _PROT1_) (NN beta) (NN protein) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (MD may) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (JJ elevated) (NN quantity)) (PP (IN of) (NP (NN inositol))) (VP (VBN seen) (PP (IN in) (NP (NP (DT the) (NNS brains)) (PP (IN of) (NP (NP (NN Alzheimer) (POS 's) (NN disease)) (NNS patients))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (DT the) (NN glycosyl) (JJ phosphatidylinositol-anchored) (NN membrane) (NN dipeptidase))) (PP (IN from) (NP (NN 3T3-L1) (NNS adipocytes)))) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ hydrophilic) (NN form)) (PP (IN of) (NP (NP (NN MDP)) (VP (VBN released) (PP (IN from) (NP (NP (DT the) (NNS cells)) (PP (IN on) (NP (NP (NN stimulation)) (PP (IN with) (NP (NN _PROT1_))))))))))) (VP (VBD was) (VP (VBN recognized) (PP (IN by) (NP (NP (NNS antibodies)) (PP (IN against) (NP (NP (DT the) (NN inositol) (JJ 1,2-cyclic) (NN monophosphate)) (VP (VBG cross-reacting) (NP (NN determinant))))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (PRP it)) (VP (VBD had) (VP (VBN been) (VP (VBN generated) (PP (IN by) (NP (NP (NN cleavage)) (PP (IN of) (NP (PRP$ its) (NN GPI) (NN anchor))))) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_)))))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN After) (S (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (NN activity)) (VP (VBD was) (ADVP (RB functionally)) (VP (VBN depleted) (PP (IN by) (S (VP (VBG treating) (NP (NNS cells)) (PP (IN with) (NP (NP (NN phorbol) (NN 12-myristate) (NN 13-acetate)) (PP (IN for) (NP (CD 24) (NNS hours)))))))))))) (, ,) (NP (PRP _PROT2_)) (VP (VBD did) (RB not) (VP (VB augment) (NP (JJ IL-1beta-induced) (NN NO) (NN production)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN effect)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD was) (ADVP (RB also)) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_) (NN inhibitor) (NN calphostin) (NN C))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NNS _PROT1_)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activity)) (PP (IN in) (NP (JJ cardiac) (NNS myocytes)))))) (, ,) (CC and) (S (NP (PRP$ its) (NN effect)) (VP (VBD was) (ADVP (RB significantly)) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN calphostin) (NN C)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (SBAR (IN that) (S (NP (DT the) (NN heart)) (VP (MD may) (VP (VB be) (NP (NP (DT a) (NN target) (NN organ)) (PP (IN for) (NP (NN _PROT1_)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT2_)) (VP (VBZ modulates) (NP (NP (JJ IL-1beta-induced) (NN iNOS) (NN expression)) (PP (IN in) (NP (NNS myocytes)))) (PP (IN through) (NP (NP (DT the) (NN V1a) (NN receptor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN mediated) (ADVP (ADVP (IN at) (JJS least)) (RB partially)) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (SBAR (IN that) (S (NP (DT the) (NN heart)) (VP (MD may) (VP (VB be) (NP (NP (DT a) (NN target) (NN organ)) (PP (IN for) (NP (NN _PROT1_)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ modulates) (NP (NP (JJ IL-1beta-induced) (NN iNOS) (NN expression)) (PP (IN in) (NP (NNS myocytes)))) (PP (IN through) (NP (NP (DT the) (NN V1a) (NN receptor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN mediated) (ADVP (ADVP (IN at) (JJS least)) (RB partially)) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (SBAR (IN that) (S (NP (DT the) (NN heart)) (VP (MD may) (VP (VB be) (NP (NP (DT a) (NN target) (NN organ)) (PP (IN for) (NP (NN _PROT_)))))))) (CC and) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ modulates) (NP (NP (JJ IL-1beta-induced) (NN iNOS) (NN expression)) (PP (IN in) (NP (NNS myocytes)))) (PP (IN through) (NP (NP (DT the) (NN V1a) (NN receptor)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN mediated) (ADVP (ADVP (IN at) (JJS least)) (RB partially)) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (ADVP (RB recently)) (VP (VBN shown) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (-LRB- -LRB-) (NN PKC) (-RRB- -RRB-) (JJ -dependent)) (NN increase)) (PP (IN in) (NP (NP (NN ACTH) (NN release)) (CC and) (NP (NN biosynthesis)))) (PP (IN in) (NP (NP (NN ovine) (JJ anterior) (NN pituitary)) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT these) (NNS cells))) (, ,) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ causes) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN from) (NP (DT the) (NN cytosol))) (PP (TO to) (NP (NP (DT the) (NN cell) (NN membrane)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (CD 5) (NN min)))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (JJ intracellular) (NNS events)) (ADJP (JJ distal) (PP (TO to) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (NN activation)) (SBAR (WHNP (WDT that)) (S (VP (VBP underlie) (NP (NN ACTH) (NN secretion))))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADVP (RB well)) (VP (VBN characterized) (PP (TO to) (NP (NN date)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT these) (NNS cells))) (, ,) (S (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ causes) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT_))) (PP (IN from) (NP (DT the) (NN cytosol))) (PP (TO to) (NP (NP (DT the) (NN cell) (NN membrane)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (CD 5) (NN min)))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (JJ intracellular) (NNS events)) (ADJP (JJ distal) (PP (TO to) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)) (SBAR (WHNP (WDT that)) (S (VP (VBP underlie) (NP (NN ACTH) (NN secretion))))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADVP (RB well)) (VP (VBN characterized) (PP (TO to) (NP (NN date)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT these) (NNS cells))) (, ,) (S (S (NP (NN _PROT_)) (ADVP (RB also)) (VP (VBZ causes) (NP (NP (DT the) (NN translocation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN from) (NP (DT the) (NN cytosol))) (PP (TO to) (NP (NP (DT the) (NN cell) (NN membrane)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (CD 5) (NN min)))))))))))) (, ,) (CC but) (S (NP (NP (DT the) (JJ intracellular) (NNS events)) (ADJP (JJ distal) (PP (TO to) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)) (SBAR (WHNP (WDT that)) (S (VP (VBP underlie) (NP (NN ACTH) (NN secretion))))))))) (VP (VBP have) (RB not) (VP (VBN been) (ADVP (RB well)) (VP (VBN characterized) (PP (TO to) (NP (NN date)))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Since) (S (NP (DT the) (NN MARCKS) (NN protein)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN neurosecretion)))))) (CC and) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NNS synaptosomes)))))))) (, ,) (S (S (NP (NNS studies)) (VP (VBD were) (VP (VBN carried) (PRT (RP out)) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NN _PROT2_)) (VP (MD might) (VP (VB cause) (NP (NN MARCKS) (NN phosphorylation)) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))))))))))) (, ,) (CC and) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (DT this) (NN phenomenon)) (VP (MD might) (VP (VB be) (VP (ADVP (RB temporally)) (VBN correlated) (PP (IN with) (NP (NP (NN _PROT_) (NN translocation)) (CC and) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN ACTH))))))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Since) (S (NP (DT the) (NN MARCKS) (NN protein)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN neurosecretion)))))) (CC and) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT1_))) (PP (IN in) (NP (NNS synaptosomes)))))))) (, ,) (S (S (NP (NNS studies)) (VP (VBD were) (VP (VBN carried) (PRT (RP out)) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (MD might) (VP (VB cause) (NP (NN MARCKS) (NN phosphorylation)) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))))))))))) (, ,) (CC and) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (DT this) (NN phenomenon)) (VP (MD might) (VP (VB be) (VP (ADVP (RB temporally)) (VBN correlated) (PP (IN with) (NP (NP (NN _PROT2_) (NN translocation)) (CC and) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN ACTH))))))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Since) (S (NP (DT the) (NN MARCKS) (NN protein)) (VP (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NN neurosecretion)))))) (CC and) (VP (VBZ is) (VP (VBN phosphorylated) (PP (IN by) (NP (NN _PROT_))) (PP (IN in) (NP (NNS synaptosomes)))))))) (, ,) (S (S (NP (NNS studies)) (VP (VBD were) (VP (VBN carried) (PRT (RP out)) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (MD might) (VP (VB cause) (NP (NN MARCKS) (NN phosphorylation)) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))))))))))) (, ,) (CC and) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (DT this) (NN phenomenon)) (VP (MD might) (VP (VB be) (VP (ADVP (RB temporally)) (VBN correlated) (PP (IN with) (NP (NP (NN _PROT2_) (NN translocation)) (CC and) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN ACTH))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT2_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT1_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT2_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT2_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT2_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (: :) (S (S (NP (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (NN _PROT_)) (VP (VBZ causes) (NP (NP (DT a) (ADJP (ADJP (JJ rapid)) (, ,) (CC and) (ADJP (JJ reversible)) (, ,)) (NN phosphorylation)) (PP (IN of) (NP (DT the) (NN MARCKS) (NN protein)))) (PP (IN in) (NP (DT the) (NN ovine) (JJ anterior) (NN pituitary))))) (: ;) (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (IN since) (S (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN MARCKS) (NN phosphorylation)))) (VP (VBZ occurs) (ADJP (RB much) (JJR earlier) (PP (IN in) (NP (NP (DT these) (NNS cells)) (SBAR (IN than) (S (VP (VBZ does) (ADJP (NN _PROT1_) (JJ trans-location)))))))))))) (, ,) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB provide) (NP (DT a) (ADJP (RBR more) (JJ sensitive)) (NN index)) (PP (IN of) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (NN _PROT2_) (NN activation))) (PP (IN than) (NP (DT the) (NN translocation) (NN assay)))))))))) (: ;) (S (NP (LST (-LRB- -LRB-) (LS 3) (-RRB- -RRB-)) (NP (DT the) (JJ close) (JJ temporal) (NN association)) (PP (IN between) (NP (NP (NN MARCKS) (NN phosphorylation)) (CC and) (NP (NP (DT the) (JJ rapid) (JJ early) (NN release)) (PP (IN of) (NP (NN ACTH))))))) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NN MARCKS) (NN phosphorylation)) (VP (MD may) (VP (VB be) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ initial) (JJ intracellular) (NNS events)) (SBAR (WHNP (WDT that)) (S (VP (VBP underly) (NP (NP (NN exocytosis)) (PP (IN of) (NP (DT the) (NN hormone)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS observations)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN bradykinin)) (, ,) (PP (IN like) (NP (NN _PROT1_))) (, ,) (VP (VBZ activates) (NP (NP (NN phospholipase) (NN C)) (SBAR (WHNP (WDT which)) (S (VP (VBZ generates) (NP (NN _PROT2_)) (PP (IN with) (NP (NP (DT a) (JJ subsequent) (NN release)) (PP (IN of) (NP (NN Ca2+))) (PP (IN from) (NP (NP (JJ intracellular) (NNS stores)) (VP (VBN followed) (PP (IN by) (NP (JJ store-operated) (NN Ca2+) (NN influx)))))))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (VP (VBD reversed) (NP (NN _PROT2_) (NN inhibition)))) (, ,) (IN whereas) (S (NP (NN _PROT_) (NN activator)) (VP (VBD inhibited) (NP (NN nitrite) (NN production)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (VP (VBD reversed) (NP (NN _PROT_) (NN inhibition)))) (, ,) (IN whereas) (S (NP (NN _PROT2_) (NN activator)) (VP (VBD inhibited) (NP (NN nitrite) (NN production)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (VP (VBD reversed) (NP (NN _PROT1_) (NN inhibition)))) (, ,) (IN whereas) (S (NP (NN _PROT2_) (NN activator)) (VP (VBD inhibited) (NP (NN nitrite) (NN production)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ inhibitory) (NN action)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ involves) (NP (CC both) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_)))) (CC and) (NP (NP (DT the) (NN transcription)) (PP (IN of) (NP (NN iNOS) (NN mRNA))))) (PP (IN in) (NP (VBN cultured) (NN rat) (NN GMC)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT An) (NN inhibitor)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NP (NN Ro31-8220)) (PRN (-LRB- -LRB-) (NP (CD 10) (NN microM)) (-RRB- -RRB-))) (, ,)) (VP (VBD abolished) (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (NN PDBu))) (S (VP (TO to) (VP (VB decrease) (NP (NP (NP (NN [Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-) (-RRB- -RSB-))) (PRN (-LRB- -LRB-) (NP (NN i)) (-RRB- -RRB-))))))) (, ,) (PP (IN without) (S (VP (VBG affecting) (NP (NP (DT the) (NN response)) (PP (TO to) (NP (NP (ADJP (ADJP (JJ maximal)) (CC or) (ADJP (JJ submaximal))) (NNS concentrations)) (PP (IN of) (NP (NN _PROT2_)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN etiology)) (PP (IN for) (NP (NP (NN diabetes) (NN mellitus)) (PP (IN in) (NP (NNS PWS)))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (TO to) (NP (NP (DT the) (JJ morbid) (NN obesity)) (CC and) (NP (JJ consequent) (NN _PROT1_) (NN resistance))))) (, ,) (SBAR (IN because) (S (NP (NP (NP (DT a) (NN decrease)) (PP (IN of) (NP (JJ _PROT2_) (NNS neurons)))) (CC and) (NP (NP (NN leptin) (NN resistance)) (PP (IN in) (NP (NNS PWS))))) (VP (MD may) (VP (VB cause) (NP (NN hyperphagia)) (, ,) (S (VP (VBG inducing) (NP (NN obesity)))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD showed) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (VP (VBZ stimulates) (NP (NP (NP (NN heat) (NN shock) (NN protein) (CD 27)) (PRN (-LRB- -LRB-) (NP (NN HSP27)) (-RRB- -RRB-))) (NN induction)) (PP (IN through) (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN activation)) (PP (IN in) (NP (JJ aortic) (JJ smooth) (NN muscle) (NN A10) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Calphostin) (NN C)) (CC and) (NP (NN ET-18-OCH) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-))) (, ,) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)))) (, ,)) (VP (VBD reduced) (NP (NP (DT the) (NN phosphorylation)) (PP (IN of) (NP (NN p38) (NN MAP) (NN kinase))) (PP (IN by) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Ca2+) (NN signalling)) (PP (IN in) (NP (NN rat) (JJ vascular) (NN smooth) (NN muscle) (NNS cells)))) (: :) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_))) (PP (IN at) (NP (NP (JJ physiological) (NN vasoconstrictor) (NNS concentrations)) (PP (IN of) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activator) (NN 4beta-phorbol) (NN 12-myristate) (NN 13-acetate)) (PRN (-LRB- -LRB-) (NP (NP (NN PMA)) (, ,) (NP (CD 100) (NN pM) (TO to) (CD 200) (NN nM))) (-RRB- -RRB-)) (, ,)) (ADVP (RB also)) (VP (VBD stimulated) (NP (NN Ca2+) (NN spiking)))) (CC and) (S (NP (DT this) (NN effect)) (VP (VBD was) (ADJP (JJ additive)) (PP (IN with) (NP (NP (DT a) (JJ submaximal) (NN concentration)) (PP (IN of) (NP (NN _PROT2_))))) (PRN (-LRB- -LRB-) (NP (CD 50) (NN pM)) (-RRB- -RRB-)))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NNS _PROT1_)) (NP (NP (NP (NN Ro-31-8220)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-))) (CC and) (NP (NP (NN calphostin) (NN C)) (PRN (-LRB- -LRB-) (NP (CD 250) (NN nM)) (-RRB- -RRB-))))) (ADVP (RB completely)) (VP (VBD blocked) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN Ca2+) (NN spiking))) (PP (IN by) (NP (CC either) (NP (NN PMA)) (CC or) (NP (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Time-dependent) (NN redistribution)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN -delta)) (CC and) (NP (NN -epsilon))) (NNS isoforms))) (PP (IN between) (NP (NP (DT the) (NP (NN membrane)) (CC and) (NP (JJ cytosolic) (NNS fractions))) (VP (VBD occurred) (PP (IN in) (NN response) (TO to) (NP (ADJP (CD 100) (NN pM)) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN for) (NP (CD 24) (NN h))) (PP (IN with) (NP (ADJP (CD 1) (NN microM)) (NN PMA)))) (VP (VP (VBD downregulated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN -delta))) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)) (, ,))))) (CC and) (VP (VBD prevented) (NP (NP (DT the) (JJ Ca2+-spiking) (NNS responses)) (PP (TO to) (NP (CC either) (NP (ADJP (CD 1) (NN nM)) (NN PMA)) (CC or) (NP (ADJP (CD 100) (NN pM)) (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN for) (NP (CD 24) (NN h))) (PP (IN with) (NP (ADJP (CD 1) (NN microM)) (NN PMA)))) (VP (VP (VBD downregulated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN -delta))) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)) (, ,))))) (CC and) (VP (VBD prevented) (NP (NP (DT the) (JJ Ca2+-spiking) (NNS responses)) (PP (TO to) (NP (CC either) (NP (ADJP (CD 1) (NN nM)) (NN PMA)) (CC or) (NP (ADJP (CD 100) (NN pM)) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN for) (NP (CD 24) (NN h))) (PP (IN with) (NP (ADJP (CD 1) (NN microM)) (NN PMA)))) (VP (VP (VBD downregulated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN -delta))) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)) (, ,))))) (CC and) (VP (VBD prevented) (NP (NP (DT the) (JJ Ca2+-spiking) (NNS responses)) (PP (TO to) (NP (CC either) (NP (ADJP (CD 1) (NN nM)) (NN PMA)) (CC or) (NP (ADJP (CD 100) (NN pM)) (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP conclude) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activation)) (VP (VBZ is) (NP (NP (DT a) (JJ necessary) (NN step)) (PP (IN in) (NP (NP (DT the) (NN signal) (NN transduction) (NN pathway)) (VP (VBG linking) (NP (NP (JJ low) (NNS concentrations)) (PP (IN of) (NP (NN _PROT2_)))) (PP (TO to) (NP (NP (NN Ca2+) (NN spiking)) (PP (IN in) (NP (NN A7r5) (NNS cells))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NP (NP (JJ fatty) (NN acid) (NN translocase/CD36)) (, ,) (NP (NN peroxisome) (JJ proliferator-activated) (NN receptor-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NNS _PROT2_) (NP (CD _PROT2_) (CC and) (CD _PROT_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor-alpha))) (NN gene) (NN expression))) (PP (IN in) (NP (JJ human) (NN subcutaneous) (NN fat))) (PP (IN by) (NP (NN lipid) (NN infusion)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NP (NP (JJ fatty) (NN acid) (NN translocase/CD36)) (, ,) (NP (NN peroxisome) (JJ proliferator-activated) (NN receptor-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NNS _PROT_) (NP (CD _PROT_) (CC and) (CD _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor-alpha))) (NN gene) (NN expression))) (PP (IN in) (NP (JJ human) (NN subcutaneous) (NN fat))) (PP (IN by) (NP (NN lipid) (NN infusion)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Induction)) (PP (IN of) (NP (NP (NP (JJ fatty) (NN acid) (NN translocase/CD36)) (, ,) (NP (NN peroxisome) (JJ proliferator-activated) (NN receptor-gamma2)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NNS _PROT1_) (NP (CD _PROT1_) (CC and) (CD _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor-alpha))) (NN gene) (NN expression))) (PP (IN in) (NP (JJ human) (NN subcutaneous) (NN fat))) (PP (IN by) (NP (NN lipid) (NN infusion)))))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ reverse) (NN transcriptase-polymerase) (NN chain) (NN reaction)) (NN analysis)))) (, ,) (NP (NP (DT the) (NN mRNA) (NN expression)) (PP (IN of) (NP (NP (JJ fatty) (NN acid) (NN translocase) (PRN (-LRB- -LRB-) (NP (NN FAT)) (-RRB- -RRB-)) (CD /CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_) (PRN (-LRB- _PROT2_) (NP (NN _PROT2_)) (-RRB- _PROT2_)) (CD _PROT2_)) (CC and) (NP (NN _PROT_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor) (-LRB- -LRB-) (NN TNF) (-RRB- -RRB-) (NN -alpha))))) (VP (VBD was) (VP (VBN investigated) (PP (IN in) (NP (JJ gluteal) (JJ subcutaneous) (JJ fat) (NNS biopsies))) (PP (IN before) (CC and) (PP (IN after) (NP (NP (CD 5) (NN h) (NNS infusions)) (PP (IN of) (NP (NP (NN saline)) (CC or) (NP (NP (NP (NN Intralipid)) (PRN (-LRB- -LRB-) (NP (NP (NNP Pharmacia)) (CC and) (NP (NNP Upjohn) (, ,) (NNP Milan) (, ,) (NNP Italy))) (-RRB- -RRB-))) (CC plus) (NP (NN heparin))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB modify) (NP (NN insulinemia))))))))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ reverse) (NN transcriptase-polymerase) (NN chain) (NN reaction)) (NN analysis)))) (, ,) (NP (NP (DT the) (NN mRNA) (NN expression)) (PP (IN of) (NP (NP (JJ fatty) (NN acid) (NN translocase) (PRN (-LRB- -LRB-) (NP (NN FAT)) (-RRB- -RRB-)) (CD /CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN _PROT_) (NN _PROT_) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_)) (CD _PROT_)) (CC and) (NP (NN _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor) (-LRB- -LRB-) (NN TNF) (-RRB- -RRB-) (NN -alpha))))) (VP (VBD was) (VP (VBN investigated) (PP (IN in) (NP (JJ gluteal) (JJ subcutaneous) (JJ fat) (NNS biopsies))) (PP (IN before) (CC and) (PP (IN after) (NP (NP (CD 5) (NN h) (NNS infusions)) (PP (IN of) (NP (NP (NN saline)) (CC or) (NP (NP (NP (NN Intralipid)) (PRN (-LRB- -LRB-) (NP (NP (NNP Pharmacia)) (CC and) (NP (NNP Upjohn) (, ,) (NNP Milan) (, ,) (NNP Italy))) (-RRB- -RRB-))) (CC plus) (NP (NN heparin))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB modify) (NP (NN insulinemia))))))))) |ET|
-1 |BT| (S1 (S (S (VP (VBG Using) (NP (NP (JJ reverse) (NN transcriptase-polymerase) (NN chain) (NN reaction)) (NN analysis)))) (, ,) (NP (NP (DT the) (NN mRNA) (NN expression)) (PP (IN of) (NP (NP (JJ fatty) (NN acid) (NN translocase) (PRN (-LRB- -LRB-) (NP (NN FAT)) (-RRB- -RRB-)) (CD /CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NP (NN _PROT1_) (NN _PROT1_) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)) (CD _PROT1_)) (CC and) (NP (NN _PROT2_))) (, ,) (CC and) (NP (NN tumor) (NN necrosis) (NN factor) (-LRB- -LRB-) (NN TNF) (-RRB- -RRB-) (NN -alpha))))) (VP (VBD was) (VP (VBN investigated) (PP (IN in) (NP (JJ gluteal) (JJ subcutaneous) (JJ fat) (NNS biopsies))) (PP (IN before) (CC and) (PP (IN after) (NP (NP (CD 5) (NN h) (NNS infusions)) (PP (IN of) (NP (NP (NN saline)) (CC or) (NP (NP (NP (NN Intralipid)) (PRN (-LRB- -LRB-) (NP (NP (NNP Pharmacia)) (CC and) (NP (NNP Upjohn) (, ,) (NNP Milan) (, ,) (NNP Italy))) (-RRB- -RRB-))) (CC plus) (NP (NN heparin))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB modify) (NP (NN insulinemia))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Marked) (NNS increases)) (PP (IN in) (NP (NP (NP (NN FAT/CD36)) (PRN (-LRB- -LRB-) (NP (CD 724+/-18) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN PPAR-gamma2)) (PRN (-LRB- -LRB-) (NP (CD 200+/-8) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 110+/-13) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 120+/-7) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 80+/-5) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN TNF-alpha) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (CD 130+/-12) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (NN pretreatment) (NNS levels)))))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD was) (NP (DT no) (NN change)) (PP (IN after) (NP (NN saline) (NN infusion))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Marked) (NNS increases)) (PP (IN in) (NP (NP (NP (NN FAT/CD36)) (PRN (-LRB- -LRB-) (NP (CD 724+/-18) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN PPAR-gamma2)) (PRN (-LRB- -LRB-) (NP (CD 200+/-8) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 110+/-13) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 120+/-7) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 80+/-5) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN TNF-alpha) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (CD 130+/-12) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (NN pretreatment) (NNS levels)))))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD was) (NP (DT no) (NN change)) (PP (IN after) (NP (NN saline) (NN infusion))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Marked) (NNS increases)) (PP (IN in) (NP (NP (NP (NN FAT/CD36)) (PRN (-LRB- -LRB-) (NP (CD 724+/-18) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN PPAR-gamma2)) (PRN (-LRB- -LRB-) (NP (CD 200+/-8) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 110+/-13) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 120+/-7) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 80+/-5) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN TNF-alpha) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (CD 130+/-12) (NN %)) (: ;) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (NP (NN comparison)) (PP (IN with) (NP (NN pretreatment) (NNS levels)))))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD was) (NP (DT no) (NN change)) (PP (IN after) (NP (NN saline) (NN infusion))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN gene) (NN expression)) (PP (IN of) (NP (NP (NN FAT/CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN TNF-alpha)))) (PP (IN in) (NP (JJ subcutaneous) (NN adipose) (NN tissue)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (JJ circulating) (NNS lipids)) (ADJP (JJ independent) (PP (IN of) (NP (NN insulin)))))))))) (CC and) (SBAR (IN that) (S (NP (JJ prolonged) (NN hyperlipidemia)) (VP (MD may) (ADVP (RB therefore)) (VP (VB contribute) (PP (TO to) (NP (NP (VBN increased) (JJ fat) (NN metabolism)) (CC and) (NP (NN storage)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (DT the) (VBN increased) (NN expression)) (PP (IN of) (NP (DT these) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN gene) (NN expression)) (PP (IN of) (NP (NP (NN FAT/CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN TNF-alpha)))) (PP (IN in) (NP (JJ subcutaneous) (NN adipose) (NN tissue)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (JJ circulating) (NNS lipids)) (ADJP (JJ independent) (PP (IN of) (NP (NN insulin)))))))))) (CC and) (SBAR (IN that) (S (NP (JJ prolonged) (NN hyperlipidemia)) (VP (MD may) (ADVP (RB therefore)) (VP (VB contribute) (PP (TO to) (NP (NP (VBN increased) (JJ fat) (NN metabolism)) (CC and) (NP (NN storage)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (DT the) (VBN increased) (NN expression)) (PP (IN of) (NP (DT these) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN gene) (NN expression)) (PP (IN of) (NP (NP (NN FAT/CD36)) (, ,) (NP (NN PPAR-gamma2)) (, ,) (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN TNF-alpha)))) (PP (IN in) (NP (JJ subcutaneous) (NN adipose) (NN tissue)))) (VP (VBZ is) (VP (VBN regulated) (PP (IN by) (NP (NP (JJ circulating) (NNS lipids)) (ADJP (JJ independent) (PP (IN of) (NP (NN insulin)))))))))) (CC and) (SBAR (IN that) (S (NP (JJ prolonged) (NN hyperlipidemia)) (VP (MD may) (ADVP (RB therefore)) (VP (VB contribute) (PP (TO to) (NP (NP (VBN increased) (JJ fat) (NN metabolism)) (CC and) (NP (NN storage)))) (PP (IN as) (NP (NP (DT a) (NN result)) (PP (IN of) (NP (NP (DT the) (VBN increased) (NN expression)) (PP (IN of) (NP (DT these) (NNS proteins))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN HEK-293) (NNS cells))) (PP (IN for) (NP (CD 2) (NN min))) (PP (IN with) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT a) (JJ mAChR) (NN agonist)) (, ,) (NP (JJ lysophosphatidic) (NN acid)) (, ,) (CC or) (NP (NN ATP))) (, ,)))) (VP (VBN followed) (PP (IN by) (NP (NN agonist) (NN washout))))) (, ,) (ADVP (RB strongly)) (S (VP (VBN increased) (PRN (-LRB- -LRB-) (PP (IN by) (NP (JJ 2-3-fold))) (-RRB- -RRB-)) (NP (NP (NP (JJ maximal) (NN _PROT1_) (NN stimulation)) (PRN (-LRB- -LRB-) (NP (QP (VBN measured) (CD >/=40)) (NN min) (JJ later)) (-RRB- -RRB-))) (PP (IN by) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (CC and) (NP (JJ platelet-derived) (NN growth) (NN factor)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT2_)))) (, ,) (CC and) (NP (NP (ADJP (RB largely) (VBN enhanced)) (NN _PROT_) (NN sensitivity)) (PP (TO to) (NP (DT these) (NN RTK) (NNS agonists))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN HEK-293) (NNS cells))) (PP (IN for) (NP (CD 2) (NN min))) (PP (IN with) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT a) (JJ mAChR) (NN agonist)) (, ,) (NP (JJ lysophosphatidic) (NN acid)) (, ,) (CC or) (NP (NN ATP))) (, ,)))) (VP (VBN followed) (PP (IN by) (NP (NN agonist) (NN washout))))) (, ,) (ADVP (RB strongly)) (S (VP (VBN increased) (PRN (-LRB- -LRB-) (PP (IN by) (NP (JJ 2-3-fold))) (-RRB- -RRB-)) (NP (NP (NP (JJ maximal) (NN _PROT1_) (NN stimulation)) (PRN (-LRB- -LRB-) (NP (QP (VBN measured) (CD >/=40)) (NN min) (JJ later)) (-RRB- -RRB-))) (PP (IN by) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (CC and) (NP (JJ platelet-derived) (NN growth) (NN factor)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT_)))) (, ,) (CC and) (NP (NP (ADJP (RB largely) (VBN enhanced)) (NN _PROT2_) (NN sensitivity)) (PP (TO to) (NP (DT these) (NN RTK) (NNS agonists))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Pretreatment)) (PP (IN of) (NP (NN HEK-293) (NNS cells))) (PP (IN for) (NP (CD 2) (NN min))) (PP (IN with) (NP (NP (NN carbachol)) (, ,) (NP (NP (DT a) (JJ mAChR) (NN agonist)) (, ,) (NP (JJ lysophosphatidic) (NN acid)) (, ,) (CC or) (NP (NN ATP))) (, ,)))) (VP (VBN followed) (PP (IN by) (NP (NN agonist) (NN washout))))) (, ,) (ADVP (RB strongly)) (S (VP (VBN increased) (PRN (-LRB- -LRB-) (PP (IN by) (NP (JJ 2-3-fold))) (-RRB- -RRB-)) (NP (NP (NP (JJ maximal) (NN _PROT_) (NN stimulation)) (PRN (-LRB- -LRB-) (NP (QP (VBN measured) (CD >/=40)) (NN min) (JJ later)) (-RRB- -RRB-))) (PP (IN by) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (CC and) (NP (JJ platelet-derived) (NN growth) (NN factor)) (, ,) (CONJP (CC but) (RB not)) (NP (NN _PROT1_)))) (, ,) (CC and) (NP (NP (ADJP (RB largely) (VBN enhanced)) (NN _PROT2_) (NN sensitivity)) (PP (TO to) (NP (DT these) (NN RTK) (NNS agonists))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (DT The) (NN body) (NN mass) (NN index)) (PRN (-LRB- -LRB-) (NP (NN BMI)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN plasma) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NN serotonin)) (, ,) (NP (NP (NP (NP (NN thyroxine)) (PRN (-LRB- -LRB-) (NP (NN T4)) (-RRB- -RRB-))) (, ,) (NP (NP (NN triiodothyronine)) (PRN (-LRB- -LRB-) (NP (NN T3)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ reverse) (NN triiodothyronine)) (PRN (-LRB- -LRB-) (NP (NN rT3)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN serum))))) (VP (VBD were) (VP (VBN evaluated) (PP (IN for) (NP (DT each) (NN subject))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT1_)) (, ,) (NP (NNS _PROT2_)) (CC and) (NP (NNS _PROT_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT1_)) (, ,) (NP (NNS _PROT_)) (CC and) (NP (NNS _PROT2_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT1_)) (, ,) (NP (NNS _PROT_)) (CC and) (NP (NNS _PROT_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT_)) (, ,) (NP (NNS _PROT1_)) (CC and) (NP (NNS _PROT2_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT_)) (, ,) (NP (NNS _PROT1_)) (CC and) (NP (NNS _PROT_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Dietary) (NNS intakes)) (PP (IN of) (NP (NP (NNS _PROT_)) (, ,) (NP (NNS _PROT_)) (CC and) (NP (NNS _PROT1_)))) (PP (IN by) (NP (JJ Japanese) (NNS women)))) (CC and) (NP (NP (DT the) (JJ inverse) (NN correlation)) (PP (IN between) (NP (NP (NN quercetin) (NN intake)) (CC and) (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ total) (NN intake)) (PP (IN of) (NP (NNS _PROT1_)))) (VP (VBD was) (VP (ADVP (RB inversely)) (VBN correlated) (PP (IN with) (NP (NP (NP (NP (DT the) (NN plasma) (JJ total) (NN _PROT2_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN TC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.236)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN plasma) (NN LDL) (NN _PROT_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN LDL-C)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.220)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))))) (, ,) (PP (IN after) (NP (NP (DT the) (NN adjustment)) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN body) (NN mass) (NN index)) (CC and) (NP (JJ total) (NN energy) (NN intake)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ total) (NN intake)) (PP (IN of) (NP (NNS _PROT1_)))) (VP (VBD was) (VP (ADVP (RB inversely)) (VBN correlated) (PP (IN with) (NP (NP (NP (NP (DT the) (NN plasma) (JJ total) (NN _PROT_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN TC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.236)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN LDL-C)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.220)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))))) (, ,) (PP (IN after) (NP (NP (DT the) (NN adjustment)) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN body) (NN mass) (NN index)) (CC and) (NP (JJ total) (NN energy) (NN intake)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ total) (NN intake)) (PP (IN of) (NP (NNS _PROT_)))) (VP (VBD was) (VP (ADVP (RB inversely)) (VBN correlated) (PP (IN with) (NP (NP (NP (NP (DT the) (NN plasma) (JJ total) (NN _PROT1_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN TC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.236)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN plasma) (NN LDL) (NN _PROT2_) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN LDL-C)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN r) (JJ =) (CD -0.220)) (, ,) (NP (NN P)) (: :) (NP (NN <) (CD 0.05)) (-RRB- -RRB-))))) (, ,) (PP (IN after) (NP (NP (DT the) (NN adjustment)) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN body) (NN mass) (NN index)) (CC and) (NP (JJ total) (NN energy) (NN intake)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN protein) (NN disruption)) (PP (IN of) (NP (ADJP (ADJP (JJ cholinergic)) (CC and) (NP (NN growth) (NN factor) (NN _PROT2_) (NN _PROT2_))) (NNS signals)))) (VP (MD could) (VP (VB underlie) (NP (NP (ADJP (ADJP (JJ cognitive)) (CC and) (ADJP (JJ neurodegerative))) (NNS aspects)) (PP (IN of) (NP (NN Alzheimer) (POS 's) (NN disease)))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN beta) (NN _PROT1_) (NN protein) (NNS fragments)) (VP (VBD had) (NP (NP (JJ diverse) (NNS effects)) (PP (IN on) (NP (NP (JJ phosphoinositide-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PI-PLC)) (-RRB- -RRB-))))) (SBAR (IN as) (S (VP (VBN assayed) (PP (IN in) (NP (NN rat) (JJ cortical) (NNS membranes))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT2_) (NN _PROT2_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT2_) (NN _PROT2_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT1_) (NN _PROT1_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT2_) (NN _PROT2_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT1_) (NN _PROT1_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT1_) (NN _PROT1_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_) (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT1_) (NN _PROT1_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT_) (NN _PROT_) (NN _PROT2_)))))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN Once) (S (NP (NP (DT the) (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform)) (NN agent)) (VP (VBZ is) (VP (VBN initiated))))) (, ,) (NP (NP (DT any) (NN stress) (NN event)) (VP (VBG ensuing) (PP (IN in) (NP (JJ adult) (NN life))))) (VP (VBZ induces) (NP (NP (DT a) (NN nerve) (NN growth) (JJ factor-mediated) (NN synthesis)) (PP (IN of) (NP (JJ normal) (JJ cellular) (NN _PROT_) (NN _PROT_) (NN isoform))) (SBAR (WHNP (WDT that)) (S (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB abnormally) (VBN phosphorylated)) (JJ abnormal) (NN _PROT_) (NN _PROT_) (NN isoform))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG becoming) (ADJP (`` ') (JJ infected) ('' ') (JJ /transformed)) (PP (IN into) (NP (DT the) (JJ same)))))) (: ;) (S (ADJP (JJ due) (PP (TO to) (NP (NP (DT the) (JJ vicious) (NN circle)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (NN blocking)) (PP (IN of) (NP (DT a) (NN _PROT1_) (NN _PROT1_) (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS responses)) (PP (IN of) (NP (NP (NP (NN serum) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))))) (PP (TO to) (NP (NP (NP (DT the) (JJ serotonergic) (NN HT1A) (NN agonist) (NN buspirone)) (PRN (-LRB- -LRB-) (NP (CD 15) (NN mg) (NN p.o.)) (-RRB- -RRB-))) (CC or) (NP (NP (DT the) (NN HTD1) (NN agonist) (NN sumatriptan)) (PRN (-LRB- -LRB-) (NP (NP (CD 6) (NN mg)) (VP (VBN injected) (ADVP (RB subcutaneously)))) (-RRB- -RRB-)))))) (VP (VBD were) (VP (VBN evaluated) (PP (IN in) (NP (CD 7) (JJ normal) (NNS men))) (PP (CC either) (PP (IN in) (NP (JJ basal) (NNS conditions))) (CC or) (PP (IN during) (NP (NP (DT an) (NN _PROT2_) (PRN (-LRB- -LRB-) (NP (NP (NN 0.15) (NN iu/kg)) (PP (IN as) (NP (DT an) (NN i.v.) (NN bolus)))) (-RRB- -RRB-)) (NN tolerance) (NN test)) (PRN (-LRB- -LRB-) (NP (NN ITT)) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Stimulation)) (PP (IN of) (NP (JJ 5HT-1D) (NNS receptors))) (PP (IN with) (NP (NN sumatriptan)))) (VP (VBD was) (ADJP (JJ unable) (PP (TO to) (NP (NP (NP (NN change)) (CC neither) (NP (NN AVP))) (CC nor) (NP (NP (NN _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Induction)) (PP (IN by) (NP (NP (NN _PROT1_)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))))) (CC and) (NP (NP (NNS enzymes)) (PP (IN of) (NP (JJ fatty) (NN acid) (NN oxidation))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Here)) (NP (PRP we)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ alters) (PP (IN in) (NP (JJ pancreatic) (NNS islets))) (NP (NP (DT the) (NN mRNA)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NNS enzymes)) (PP (IN of) (NP (JJ free) (JJ fatty) (NN acid) (NN metabolism)))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-2)) (-RRB- -RRB-)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN overexpression)) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA)) (PP (IN by) (NP (JJR more) (IN than) (RB 10-fold))) (PP (IN in) (NP (NP (NP (NN epididymal)) (, ,) (NP (NN retroperitoneal)) (, ,) (CC and) (NP (NP (JJ subcutaneous) (JJ fat) (NN tissue)) (PP (IN of) (NP (JJ normal))))) (, ,) (CONJP (CC but) (RB not)) (PP (IN of) (NP (JJ leptin-receptor-defective) (JJ obese) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (PP (IN By) (S (ADVP (RB directly)) (VP (VBG regulating) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NNS enzymes)) (PP (PP (IN of) (NP (JJ free) (JJ fatty) (NN acid) (NN metabolism))) (CC and) (PP (IN of) (NP (NN _PROT1_)))))))))) (, ,) (NP (NN _PROT2_)) (VP (VBZ controls) (NP (NP (JJ intracellular) (NN triglyceride) (NN content)) (PP (IN of) (NP (NP (JJ certain) (NNS nonadipocytes)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NNS adipocytes)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NP (DT the) (NNS MAPKs)) (, ,) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NN PMA)))))))) (VP (VBD was) (VP (VBN inhibited) (PP (PP (IN by) (NP (NP (NN downregulation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-)))))) (, ,) (PP (IN by) (NP (DT the) (NN tyrosine) (NN kinase) (NN inhibitor) (NN genistein))) (CC and) (PP (IN by) (NP (NP (NP (NP (NN MAPK) (NN kinase)) (PRN (-LRB- -LRB-) (NP (NN MEK)) (-RRB- -RRB-))) (NN inhibitor)) (, ,) (NP (NN PD98059))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ activates) (NP (DT the) (JJ 42/44kDa) (NNS MAPKs)) (PP (IN through) (NP (NP (DT a) (NN signal) (NN transduction) (NN pathway)) (SBAR (WHNP (WDT that)) (S (VP (VBZ involves) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN AVP-V1) (NN receptor)) (, ,) (NP (NN tyrosine) (NN kinase)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN MEK)))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Similarly)) (, ,) (NP (NP (NN carbachol)) (, ,) (CONJP (CC but) (RB not)) (NP (NP (NN _PROT1_)) (CC or) (NP (NN DDAVP))) (, ,)) (VP (VBD induced) (NP (NP (DT a) (JJ significant) (NN increase)) (PP (IN in) (NP (NP (NP (JJ membrane-associated) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN enzyme) (NN activity))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (PRP _PROT1_)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN distribution)) (PP (IN of) (NP (DT any) (NN _PROT2_) (NN isoform)))))) (VP (VBD tested)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Treatment)) (PP (IN with) (NP (PRN (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NN -trifluoro-ABA)))) (ADVP (RB strongly)) (VP (VBD inhibited) (NP (NP (DT the) (JJ _PROT1_) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NN I-1)) (VP (VBN encoded) (PP (IN by) (NP (NN RAmy1A)))))) (PP (IN in) (NP (NP (DT the) (JJ aleurone) (NNS layers)) (PP (IN of) (NP (NN embryoless) (NNS half-seeds)))))) (PP (IN at) (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NP (NN transcription)) (, ,) (NP (NN protein) (NN synthesis)) (, ,) (CC and) (NP (NN enzyme) (NN activity))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Chronic) (JJ central) (NN _PROT1_) (NN infusion)) (VP (VP (VBZ enhances) (NP (JJ insulin-stimulated) (NN glucose) (NN metabolism))) (CC and) (VP (VBZ favors) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NNS _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ marked) (NN contrast))) (, ,) (NP (JJ intracerebroventricular) (NN _PROT_) (NN administration)) (VP (VBD was) (VP (VBN accompanied) (PP (IN by) (NP (NP (DT the) (NN maintenance)) (PP (IN of) (NP (NP (JJ high) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_)) (NP (NN expression)))) (PP (IN in) (NP (PDT all) (DT these) (NNS tissues))))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT1_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT1_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT1_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN _PROT_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN While) (S (NP (NN _PROT_)) (VP (VP (VBZ maintains)) (CC or) (VP (VBZ favors) (NP (NP (JJ energy-dissipating) (NNS mechanisms)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))))))) (, ,) (S (NP (DT the) (JJ latter)) (VP (VBP are) (VP (ADVP (RB markedly)) (VBN depressed) (PP (IN in) (NP (JJ pair-fed) (NNS rats)))))))) |ET|
+1 |BT| (S1 (S (NP (NN Melatonin)) (VP (VBZ inhibits) (NP (NP (NN _PROT1_) (NN response)) (PP (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))) (, ,) (CC but) (PP (RB not) (TO to) (NP (NN angiotensin) (CD II)))) (PP (IN in) (NP (JJ normal) (NNS men))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN In) (S (NP (NN order)) (VP (TO to) (VP (VB establish) (SBAR (IN whether) (S (NP (NN melatonin)) (VP (VBZ alters) (NP (ADJP (ADJP (JJ basal)) (CC and/or) (ADJP (JJ stimulated))) (NN _PROT1_) (NN secretion))))))))) (, ,) (S (NP (CD 18) (JJ normal) (NNS men)) (VP (VBD were) (VP (VBN treated) (PRN (-LRB- -LRB-) (NP (NN p.o.)) (-RRB- -RRB-)) (PP (IN with) (NP (NP (NP (NP (NP (NP (ADJP (QP (CD 6) (CC or) (CD 12)) (NN mg)) (NN melatonin)) (CC or) (NP (NN placebo))) (PP (PP (IN in) (NP (NP (JJ basal) (NNS conditions)) (PRN (-LRB- -LRB-) (NP (NN N-6) (NNS subjects)) (-RRB- -RRB-)))) (CC or) (PP (RB concomitantly) (TO to) (NP (NP (DT the) (NN administration)) (PP (IN of) (NP (NN _PROT2_))))))) (-LRB- -LRB-) (NP (CD O.15) (NN IU/kg) (NN body) (NN weight)) (PP (IN in) (NP (DT an) (NN i.v.) (NN bolus))) (-RRB- -RRB-)) (PRN (-LRB- -LRB-) (NP (NN N-6) (NNS subjects)) (-RRB- -RRB-))) (CC or) (NP (NP (NN angiotensin) (CD II)) (PRN (-LRB- -LRB-) (NP (NP (NP (VBG increasing) (NNS doses)) (PP (IN of) (NP (QP (CD 4) (, ,) (CD 8) (CC and) (CD 16)) (NN ng/kg/min)))) (, ,) (PP (IN at) (NP (NP (NNS intervals)) (PP (IN of) (NP (CD 20) (NN min)))))) (-RRB- -RRB-)))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NN _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))) (VP (VBD was) (ADVP (RB significantly)) (VP (VBN reduced) (PP (IN by) (NP (NN melatonin) (NN treatment))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Effect)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion))) (PP (IN on) (NP (NP (DT the) (JJ abnormal) (NN _PROT2_) (NN response)) (PP (TO to) (NP (NN hypoglycaemia))) (PP (IN in) (NP (JJ _PROT_) (NNS diabetics)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Effect)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion))) (PP (IN on) (NP (NP (DT the) (JJ abnormal) (NN _PROT_) (NN response)) (PP (TO to) (NP (NN hypoglycaemia))) (PP (IN in) (NP (JJ _PROT2_) (NNS diabetics)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Effect)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT_) (NN secretion))) (PP (IN on) (NP (NP (DT the) (JJ abnormal) (NN _PROT1_) (NN response)) (PP (TO to) (NP (NN hypoglycaemia))) (PP (IN in) (NP (JJ _PROT2_) (NNS diabetics)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN Since) (S (NP (JJ previous) (NNS studies)) (VP (VBD showed) (SBAR (IN that) (S (NP (NN AVP) (NN secretion)) (VP (VBZ is) (VP (VBN influenced) (PP (IN by) (NP (NP (DT the) (NN persistence)) (PP (IN of) (NP (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD wondered) (SBAR (IN whether) (S (NP (DT this) (NN factor)) (ADVP (RB also)) (VP (VBZ regulates) (NP (NN _PROT2_) (NN secretion))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (NP (JJ Case-control) (NN study)) (: :) (S (NP (NP (DT the) (JJ _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycaemia)))) (VP (VBD was) (VP (VBN measured) (PP (IN in) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ diabetic))) (NNS patients)) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (JJ residual) (JJ endogenous) (NN _PROT_) (NN secretion)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (NP (JJ Case-control) (NN study)) (: :) (S (NP (NP (DT the) (JJ _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT_) (NN hypoglycaemia)))) (VP (VBD was) (VP (VBN measured) (PP (IN in) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ diabetic))) (NNS patients)) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (JJ residual) (JJ endogenous) (NN _PROT2_) (NN secretion)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN DESIGN)) (: :) (NP (JJ Case-control) (NN study)) (: :) (S (NP (NP (DT the) (JJ _PROT_) (NN response)) (PP (TO to) (NP (JJ _PROT1_) (NN hypoglycaemia)))) (VP (VBD was) (VP (VBN measured) (PP (IN in) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (JJ diabetic))) (NNS patients)) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (JJ residual) (JJ endogenous) (NN _PROT2_) (NN secretion)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Blood) (NNS samples)) (PP (IN for) (NP (NN _PROT1_) (NN assay)))) (VP (VBD were) (VP (VBN taken) (PP (ADVP (RB just)) (PP (IN before) (NP (NP (NP (DT the) (JJ rapid) (NN injection)) (PP (IN of) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NN time) (CD 0)) (-RRB- -RRB-)))) (CC and) (PP (IN at) (NP (NN time))) (NP (QP (CD 15) (, ,) (CD 30) (, ,) (CD 45) (CC and) (CD 60)) (NN min))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (DT a) (JJ residual) (JJ endogenous) (NN _PROT1_) (NN secretion)) (VP (VBZ exerts) (NP (NP (DT a) (JJ partial) (JJ protective) (NN action)) (PP (IN against) (NP (NP (DT the) (JJ hypothalamic-pituitary) (NN disorder)) (VP (VBG affecting) (NP (NP (DT the) (JJ _PROT2_) (JJ secretory) (NN system)) (PP (IN in) (NP (NN IDDM)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBD led) (S (NP (PRP us)) (VP (TO to) (VP (VB conclude) (SBAR (IN that) (S (NP (NP (NN inositol) (NN trisphosphate)) (NN [corrected) (-RRB- -RSB-)) (VP (VBZ causes) (NP (NN Ca2+) (NN mobilization)) (PP (IN by) (NP (NP (JJ muscarinic) (NN activation)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (S (VP (VBG leading) (PP (TO to) (NP (NP (JJ intracellular) (NN translocation)) (PP (IN of) (NP (NN _PROT2_) (NNS granules))) (PP (TO to) (NP (NP (DT the) (JJ ready-releasable) (NN pool)) (PP (IN in) (NP (JJ pancreatic) (NNS beta-cells))))))) (PP (IN via) (NP (NP (JJ Ca2+/calmodulin-dependent) (NN phosphorylation)) (PP (IN of) (NP (NN myosin) (NN light) (NNS chains)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN DNase1) (NNS footprints)) (VP (VBP suggest) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (QP (IN at) (JJS least) (CD three)) (NNS types)) (PP (IN of) (NP (NN transcription) (NNS factors))))) (PP (IN in) (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN regulation)) (PP (IN of) (NP (NN _PROT1_) (NNS genes))) (PP (IN by) (NP (NN _PROT2_)))) (ADVP (RB therefore)) (VP (VBZ involves) (NP (NP (DT an) (NN interplay)) (PP (IN of) (NP (NP (QP (IN at) (JJS least) (CD three)) (JJ different) (NNS types)) (PP (IN of) (NP (NN transcription) (NN factor))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Analyses)) (PP (IN of) (NP (NP (NN hormone) (NN regulation)) (PP (IN of) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN mRNA)) (PP (IN for) (NP (DT the) (NN aleurone) (NN RNase)))))))))) (VP (VBD revealed) (SBAR (IN that) (S (, ,) (PP (IN like) (NP (NP (DT the) (NN pattern)) (PP (IN for) (NP (NN _PROT1_))))) (, ,) (S (NP (NN mRNA) (NNS levels)) (VP (VBD increased) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ _PROT2_) (NN _PROT2_))))))) (, ,) (CC and) (S (NP (PRP$ its) (NN antagonist) (JJ abscisic) (NN acid)) (VP (VBD prevented) (NP (DT this) (NN effect))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Quantitative) (NNS studies)) (PP (IN at) (NP (JJ early) (NNS times)))) (VP (VBD demonstrated) (SBAR (IN that) (S (NP (NP (NN cycloheximide) (NN treatment)) (PP (IN of) (NP (NN aleurone) (NNS layers)))) (VP (VBD increased) (NP (NN mRNA) (NNS levels)) (ADVP (RB 4-fold)) (, ,) (SBAR (IN whereas) (S (NP (NP (DT a) (NN combination)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC plus) (NP (NN cycloheximide) (NN treatment))))) (VP (VBD was) (VP (VBN required) (S (VP (TO to) (VP (VB increase) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (PP (TO to) (NP (DT the) (JJ same) (NN extent)))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (PP (IN at) (NP (VBG increasing) (NN _PROT1_) (NNS concentrations))) (, ,) (NP (NP (VBG increasing) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN barley)) (PRN (-LRB- -LRB-) (NP (NN Hordeum) (NN vulgare)) (-RRB- -RRB-))) (NNS cells)))) (VP (VBD showed) (NP (NP (DT the) (VBN enhanced) (NP (NP (NN _PROT2_) (NN secretion)) (CC and) (NP (NN vacuolation))) (NN characteristic)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN response)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (PP (IN at) (NP (VBG increasing) (NN _PROT1_) (NNS concentrations))) (, ,) (NP (NP (VBG increasing) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN barley)) (PRN (-LRB- -LRB-) (NP (NN Hordeum) (NN vulgare)) (-RRB- -RRB-))) (NNS cells)))) (VP (VBD showed) (NP (NP (DT the) (VBN enhanced) (NP (NP (NN _PROT_) (NN secretion)) (CC and) (NP (NN vacuolation))) (NN characteristic)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (NP (PRP we)) (VP (VBD found) (SBAR (IN that) (S (PP (IN at) (NP (VBG increasing) (NN _PROT_) (NNS concentrations))) (, ,) (NP (NP (VBG increasing) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN barley)) (PRN (-LRB- -LRB-) (NP (NN Hordeum) (NN vulgare)) (-RRB- -RRB-))) (NNS cells)))) (VP (VBD showed) (NP (NP (DT the) (VBN enhanced) (NP (NP (NN _PROT1_) (NN secretion)) (CC and) (NP (NN vacuolation))) (NN characteristic)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN satiety) (NN factor)) (SBAR (WHNP (WDT which)) (S (VP (VBZ acts) (PP (IN within) (NP (DT the) (NN hypothalamus))) (S (VP (TO to) (VP (VB decrease) (NP (NP (DT the) (NNS levels)) (PP (IN of) (NP (NP (NP (JJ several) (NNS neuropeptides)) (VP (VBG stimulating) (NP (NN food) (NN intake)))) (PRN (-LRB- -LRB-) (PP (IN among) (NP (PRP them))) (, ,) (NP (NN _PROT2_) (NN _PROT2_) (CD [NPY)) (-RRB- -RSB-) (-RRB- -RRB-)))))))))))) (, ,) (SBAR (IN while) (S (VP (VBG increasing) (NP (NP (DT those)) (SBAR (WHNP (WDT that)) (S (VP (VBP inhibit) (NP (NN food) (NN intake)))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (DT the) (JJ above) (NNS data)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT a) (JJ direct) (NN ability)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB promote) (NP (NN TRH) (NN biosynthesis)) (PP (IN through) (NP (NP (NNS actions)) (PP (IN on) (NP (NN TRH) (NNS neurons)))))))))))))) (, ,) (NP (NP (NN addition)) (PP (IN of) (NP (NN a-MSH)))) (VP (VBD produced) (NP (NP (DT a) (CD 3.5) (NN fold) (NN increase)) (PP (IN in) (NP (NP (NN TRH) (NN biosynthesis)) (CC and) (NP (NN release))))) (, ,) (SBAR (IN whereas) (S (NP (NN _PROT2_) (NN treatment)) (VP (VBD suppressed) (NP (NN ~3) (NN fold) (NN proTRH) (NN biosynthesis)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (VBN increased) (NN _PROT1_) (NN signaling)) (PP (TO to) (NP (NP (DT the) (NP (NN _PROT2_)) (CC and) (NP (JJ POMC) (NNS neurons))) (PP (IN in) (NP (DT the) (NN ARC)))))))) (PP (IN by) (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (VBG circulating) (NN _PROT_))))) (PP (IN during) (NP (JJ normal) (NN feeding)))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (VBN increased) (NN _PROT1_) (NN signaling)) (PP (TO to) (NP (NP (DT the) (NP (NN _PROT_)) (CC and) (NP (JJ POMC) (NNS neurons))) (PP (IN in) (NP (DT the) (NN ARC)))))))) (PP (IN by) (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (VBG circulating) (NN _PROT2_))))) (PP (IN during) (NP (JJ normal) (NN feeding)))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (VBN increased) (NN _PROT_) (NN signaling)) (PP (TO to) (NP (NP (DT the) (NP (NN _PROT1_)) (CC and) (NP (JJ POMC) (NNS neurons))) (PP (IN in) (NP (DT the) (NN ARC)))))))) (PP (IN by) (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (VBG circulating) (NN _PROT2_))))) (PP (IN during) (NP (JJ normal) (NN feeding)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (ADVP (RB Rapidly)) (VP (VP (VBZ Inhibits) (NP (NP (JJ Hypothalamic) (NN _PROT2_) (NN _PROT2_)) (NN Secretion))) (CC and) (VP (VBZ Stimulates) (NP (NP (JJ Corticotropin-Releasing) (NN Hormone) (NN Secretion)) (PP (IN in) (NP (JJ Adrenalectomized) (NNS Mice)))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (MD may) (ADVP (RB rapidly)) (VP (VBP inhibit) (NP (NN food) (NN intake)) (PP (IN by) (S (VP (VBG altering) (NP (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NNS neuropeptides)) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NP (DT a) (NN stimulator)) (PP (IN of) (NP (NN food) (NN intake)))) (, ,) (CC and/or) (NP (NP (JJ corticotropin-releasing) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN CRH)) (-RRB- -RRB-)))))))) (, ,) (NP (NP (DT an) (NN inhibitor)) (PP (IN of) (NP (NN food) (NN intake)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD measured) (NP (NP (NNS concentrations)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN CRH)) (PP (IN in) (NP (JJ specific) (JJ hypothalamic) (NNS regions))))) (NNS [i.e.)) (, ,) (NP (NP (NP (JJ arcuate) (NN nucleus)) (PRN (-LRB- -LRB-) (NP (NN ARC)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ paraventricular) (NN nucleus)) (PRN (-LRB- -LRB-) (NP (NN PVN)) (-RRB- -RRB-))) (, ,) (NP (JJ ventromedial) (NN nucleus)) (CC and) (NP (JJ dorsomedial) (NN nucleus))))) (-RRB- -RSB-) (PP (IN of) (NP (ADJP (CD 7-) (TO to) (JJ 8-wk-old)) (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ ob/ob))) (NNS mice)))) (PP (IN at) (NP (QP (CD 1) (CC or) (CD 3)) (NN h))) (PP (IN after) (NP (JJ intracerebroventricular) (NN _PROT2_) (NN administration)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT No) (JJ rapid-onset) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (JJ hypothalamic) (NN _PROT2_)) (CC or) (NP (NN CRH) (NNS concentrations))))) (VP (VBD were) (VP (VBN observed) (PP (IN in) (NP (JJ intact) (NNS mice))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN addition)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (NP (JJ hypothalamic) (NNS preparations)) (PP (IN from) (NP (JJ intact) (NNS mice)))))) (ADVP (RB also)) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN _PROT2_)) (CC or) (NP (NN CRH) (NN secretion))))))) |ET|
+1 |BT| (S1 (S (PP (IN Within) (NP (NP (CD 20) (NN min)) (PP (IN after) (NP (NP (NN exposure)) (PP (TO to) (NP (NN _PROT1_))))))) (, ,) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (JJ hypothalamic) (NNS preparations)) (VP (VBN obtained) (PP (IN from) (NP (JJ adrenalectomized) (NNS mice))))))) (VP (VBD was) (VP (VBN lowered) (PP (IN by) (NP (NP (CD 27) (NN %)) (CC and) (NP (NN CRH) (NN secretion)))))) (VP (VBD was) (VP (VBN elevated) (PP (IN by) (NP (CD 51) (NN %))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ current) (NN study)) (VP (VBZ demonstrates) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB rapidly)) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NN _PROT2_)) (CC and) (NP (NN CRH)))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT these) (NNS actions)) (PP (IN of) (NP (NN _PROT_))) (PP (IN within) (NP (DT the) (NN hypothalamus)))) (VP (VBP are) (VP (VBN restrained) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN corticosterone))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ current) (NN study)) (VP (VBZ demonstrates) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (ADVP (RB rapidly)) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NN _PROT_)) (CC and) (NP (NN CRH)))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT these) (NNS actions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN within) (NP (DT the) (NN hypothalamus)))) (VP (VBP are) (VP (VBN restrained) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN corticosterone))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ current) (NN study)) (VP (VBZ demonstrates) (SBAR (SBAR (IN that) (S (NP (NN _PROT_)) (ADVP (RB rapidly)) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (JJ hypothalamic) (NN _PROT1_)) (CC and) (NP (NN CRH)))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT these) (NNS actions)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN within) (NP (DT the) (NN hypothalamus)))) (VP (VBP are) (VP (VBN restrained) (PP (IN by) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN corticosterone))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PP (IN as) (NP (NP (DT a) (NN modulator)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (PP (IN On) (DT the) (NN basis) (IN of) (NP (NP (JJ far-Western) (NN blot)) (CC and) (NP (NP (NP (NN plasmon) (NN resonance)) (PRN (-LRB- -LRB-) (NP (NN BIAcore)) (-RRB- -RRB-))) (NNS experiments)))) (, ,) (NP (PRP we)) (VP (VBP show) (ADVP (RB here)) (SBAR (IN that) (S (NP (NP (NP (JJ recombinant) (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN bPrP)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN 25-242)) (-RRB- -RRB-))) (ADVP (RB strongly)) (VP (VBZ interacts) (PP (IN with) (NP (NP (DT the) (JJ catalytic) (JJ alpha/alpha) (`` ') (NNS subunits)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (ADVP (RB also)) (VP (VBN termed) (S (PRN (`` ') (NP (NN casein) (NN kinase) (CD 2)) ('' ')))) (-RRB- -RRB-)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB also)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ counteracts) (NP (NP (DT the) (NN inhibition)) (PP (IN of) (NP (NP (NN calmodulin) (NN phosphorylation)) (VP (VBN promoted) (PP (IN by) (NP (NP (DT the) (JJ regulatory) (NN beta) (NNS subunits)) (PP (IN of) (NP (NN _PROT2_))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (VBN truncated) (NN form)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBG encompassing) (NP (NP (DT the) (JJ C-terminal) (NN domain)) (PRN (-LRB- -LRB-) (NP (NNS residues) (NP (CD 105-242))) (-RRB- -RRB-))))))) (VP (VP (VBZ interacts) (PP (IN with) (NP (NN _PROT2_)))) (CC but) (VP (VBZ does) (RB not) (VP (VB affect) (NP (PRP$ its) (JJ catalytic) (NN activity))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP disclose) (NP (NP (DT the) (NN potential)) (PP (IN of) (NP (DT the) (NN _PROT1_))) (S (VP (TO to) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT a) (JJ pleiotropic) (NN _PROT_) (NN _PROT_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (RB particularly) (JJ abundant) (PP (IN in) (NP (DT the) (NN brain)))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP disclose) (NP (NP (DT the) (NN potential)) (PP (IN of) (NP (DT the) (NN _PROT1_))) (S (VP (TO to) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NP (DT a) (JJ pleiotropic) (NN _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (RB particularly) (JJ abundant) (PP (IN in) (NP (DT the) (NN brain)))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP disclose) (NP (NP (DT the) (NN potential)) (PP (IN of) (NP (DT the) (NN _PROT_))) (S (VP (TO to) (VP (VB modulate) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NP (DT a) (JJ pleiotropic) (NN _PROT2_) (NN _PROT2_)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (RB particularly) (JJ abundant) (PP (IN in) (NP (DT the) (NN brain)))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN _PROT2_) (NN turnover)) (PP (IN in) (NP (NP (NN endometrium)) (PP (IN of) (NP (NNS ewes)))))) (VP (VBZ is) (VP (VBN influenced) (PP (IN by) (NP (NP (NN stage)) (PP (IN of) (NP (NP (NP (DT the) (NN estrous) (NN cycle)) (, ,) (NP (NN pregnancy)) (, ,) (CC and) (NP (JJ intrauterine) (NN infusion))) (PP (IN of) (NP (NN ovine) (NN conceptus) (JJ secretory) (NNS proteins))))))))))) |ET|
+1 |BT| (S1 (S (NP (CD Three) (NNS experiments)) (PRN (-LRB- -LRB-) (NP (NNP Exp)) (-RRB- -RRB-)) (VP (VBD assessed) (NP (NP (DT the) (NN influence)) (PP (IN of) (NP (NP (NN stage)) (PP (IN of) (NP (NP (DT the) (NN estrous) (NN cycle)) (, ,) (NP (NN pregnancy)) (, ,) (CC and) (NP (NP (JJ intrauterine) (NN infusion)) (PP (IN of) (NP (NP (JJ ovine) (NN conceptus) (JJ secretory) (NNS proteins)) (PRN (-LRB- -LRB-) (NP (NN oCSP)) (-RRB- -RRB-))))))))) (PP (IN on) (NP (NP (NN turnover)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (DT the) (JJ putative) (NN second-messenger)) (PP (IN for) (NP (JJ _PROT2_) (NN secretion))) (PP (IN of) (NP (NN prostaglandin) (NN F2) (NN alpha)))) (-RRB- -RRB-))))))) (PP (IN in) (NP (NN ovine) (NN endometrium))) (PP (IN during) (NP (NP (NP (NN luteolysis)) (CC and) (NP (JJ maternal) (NN recognition))) (PP (IN of) (NP (NN pregnancy)))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN For) (NP (DT each) (NN Exp))) (, ,) (NP (ADJP (CD 100) (NN mg)) (NN endometrium)) (VP (VBD was) (VP (VP (VBN incubated) (, ,) (PP (IN in) (NP (NN duplicate))) (, ,) (PP (IN for) (NP (NP (CD 2) (NN h)) (PP (IN with) (NP (CD 10) (NN microCi) (NN [3H) (-RRB- -RSB-) (NN inositol)))))) (CC and) (VP (VBN treated) (PP (IN with) (NP (NP (ADJP (QP (CD 0) (CC or) (CD 100)) (NN nM)) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 20) (NN min)))) (, ,) (ADVP (RB then))))) (S (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol) (NN mono-)) (, ,) (NP (NN bis-)) (, ,) (CC and) (NP (NP (NNS trisphosphates)) (PRN (-LRB- -LRB-) (NP (NP (NN IP1)) (, ,) (NP (NN IP2)) (, ,) (CC and) (NP (NN _PROT2_)) (, ,) (ADVP (RB respectively))) (-RRB- -RRB-)))) (VP (VBD were) (VP (VBN quantified)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS objectives)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD were) (S (VP (VP (TO to) (VP (VP (VB evaluate)) (CC and) (VP (VB compare) (NP (NP (DT the) (NNS actions)) (PP (IN of) (NP (NP (NP (NN endothelin-1)) (PRN (-LRB- -LRB-) (NP (NN ET-1)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))))) (PP (IN on) (NP (NP (NN 45Ca2+) (NN mobilization)) (PP (IN in) (NP (JJ permeabilized) (NN rat) (NN myometrial) (NNS cells))))))))) (CC and) (VP (TO to) (VP (VB examine) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT the) (NN inositol) (NN lipid) (NN cycle))) (PP (IN in) (NP (JJ intact) (NNS myocytes))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT All) (CD four) (NNS agonists)) (VP (VBD caused) (NP (NP (DT a) (JJ biphasic) (NN release)) (PP (IN of) (NP (NN 45Ca2+))) (PP (IN from) (NP (NP (JJ non-mitochondrial) (NN pool)) (PRN (-LRB- -LRB-) (NP (NN s)) (-RRB- -RRB-))))) (, ,) (PP (IN with) (NP (NP (DT the) (NN rank) (NN order)) (PP (IN of) (NP (NN potency))))))) (: :) (NP (NP (NN _PROT1_) (NN >) (NN PGF2) (NN alpha)) (NP (NN >) (NN ET-1) (NN >) (NN _PROT2_))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Endothelin-1)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NN _PROT2_) (NN _PROT2_) (NN accumulation)) (PP (IN at) (NP (NP (NNS concentrations)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (SBAR (WHNP (WDT that)) (S (VP (VBD promoted) (NP (NN 45Ca2+) (NN efflux)))))))))))) (, ,) (IN whereas) (S (NP (NP (ADJP (QP (RB about) (CD 100) (NNS times)) (JJR higher)) (NNS concentrations)) (PP (IN of) (NP (NN PGF2) (NN alpha)))) (VP (VBD were) (VP (VBN needed) (S (VP (TO to) (VP (VB activate) (NP (DT this) (NN signaling) (NN pathway)) (PP (IN in) (NP (JJ intact) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ is) (VP (VBN concluded) (SBAR (IN that) (S (NP (NP (DT the) (JJ primary) (NN action)) (PP (IN of) (NP (NN PGF2) (NN alpha))) (PP (IN in) (NP (JJ myometrial) (NNS cells)))) (VP (VBZ is) (S (VP (TO to) (VP (VB enhance) (NP (NN Ca2+) (NN influx))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN ET-1))) (NNS receptors)) (VP (VBP are) (VP (VBN coupled) (PP (TO to) (NP (NN phospholipase) (NN C))) (, ,) (S (VP (VP (VBG generating) (NP (NN _PROT2_))) (CC and) (VP (VBG raising) (NP (NP (DT the) (JJ intracellular) (NN concentration)) (PP (IN of) (NP (JJ free) (NN Ca2+)))) (PP (IN from) (NP (ADJP (ADJP (JJ intracellular)) (CONJP (RB as) (RB well) (IN as)) (ADJP (JJ extracellular))) (NNS sources))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (DT a) (JJ biphasic) (NN increase)) (PP (IN in) (NP (NP (DT the) (JJ intracellular) (NN Ca2+) (NN concentration)) (PP (IN of) (NP (NN porcine) (NN myometrial) (NNS cells)))))))) (: :) (NP (NP (NP (NN participation)) (PP (IN of) (NP (DT a) (ADJP (NN pertussis) (JJ toxin-insensitive)) (NN G-protein)))) (, ,) (NP (NN _PROT2_) (JJ _PROT2_) (NN Ca2+) (NN pool)) (, ,) (CC and) (NP (NN Ca2+) (NNS channels))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Administration)) (PP (IN of) (NP (NP (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microM)) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 15) (NN sec)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN formation)) (PP (IN by) (NP (CD 61) (NN %)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Pretreatment)) (PP (IN with) (NP (NP (NN pertussis) (NN toxin)) (PRN (-LRB- -LRB-) (NP (NP (NN PTX)) (, ,) (NP (CD 1) (NN microgram/ml))) (-RRB- -RRB-)))) (PP (IN for) (NP (CD 2) (NN hr)))) (VP (VBD failed) (S (VP (TO to) (VP (VB alter) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT2_) (NN formation))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN U-73122)) (PRN (-LRB- -LRB-) (NP (CD 3) (NN microM)) (-RRB- -RRB-))) (ADVP (RB also)) (VP (VBD abolished) (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN formation))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ present) (NN study)))) (VP (VBD was) (S (VP (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (NN _PROT1_)) (VP (VBN given) (ADVP (ADVP (ADVP (RB subcutaneously)) (PRN (-LRB- -LRB-) (NP (NN SC)) (-RRB- -RRB-))) (CC and) (ADVP (ADVP (RB intracerebroventricularly)) (PRN (-LRB- -LRB-) (NP (NN ICV)) (-RRB- -RRB-)))))) (VP (VBZ influences) (NP (NP (DT the) (NN secretion)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN glucagon)) (CC and) (NP (NN glucose)))))))))) (CC and) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (NP (DT these) (NNS variables)) (PP (IN of) (NP (NN suckling))))) (PP (IN in) (NP (JJ lactating) (NNS rats)))) (VP (VBZ is) (VP (VBN mediated) (PP (IN by) (NP (JJ oxytocinergic) (NNS mechanisms)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Subcutaneous) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD increased) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)) (ADVP (RB significantly))))) |ET|
+1 |BT| (S1 (S (NP (NP (CD Two) (NNS nanograms)) (S (NP (NP (NN _PROT1_)) (VP (VBN given) (NP (NN ICV)))) (VP (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)))) (CC but) (VP (VBD caused) (NP (NP (DT a) (JJ significant) (NN rise)) (PP (IN in) (NP (NN _PROT2_) (NNS levels)))) (PP (IN at) (NP (DT this) (NN time) (NN point))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT2_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT2_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT1_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT1_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT2_) (NN _PROT_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT1_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN _PROT_) (NN antagonist) (NN 1-deamino-2-D-Tyr-) (-LRB- -LRB-) (NN OEt) (-RRB- -RRB-) (NN -4-Thr-8-Orn-oxytocin)) (VP (VBN administered))) (ADVP (RB ICV)) (VP (VBD increased) (NP (NN _PROT_) (NNS levels)))) (S (NP (NP (PRP itself)) (CC and) (ADVP (RB therefore)) (NP (NP (DT the) (NN effect)) (PP (IN on) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion))))) (VP (VBD was) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB evaluate))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Intracerebroventricular) (NNS injections)) (PP (IN of) (NP (ADJP (CD 200) (NN ng)) (NN _PROT1_)))) (VP (VBD caused) (NP (NP (DT a) (JJ significant) (NN rise)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN _PROT2_))) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (NP (NN glucagon)) (CC and) (NP (NN glucose))) (NNS levels)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (JJ nanogram) (NNS amounts)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN administered))))) (ADVP (RB ICV)) (VP (VBP cause) (NP (NP (DT a) (NN rise)) (PP (IN of) (NP (NN _PROT2_) (NNS levels))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN 8-OH-DPAT)) (ADVP (RB also)) (VP (VP (VBD increased) (NP (NN _PROT1_))) (CC and) (VP (VBD decreased) (NP (NP (NP (NN CCK)) (CC and) (NP (NN somatostatin))) (NNS levels))))) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT that)) (S (VP (VBD were) (VP (VBN blocked) (PP (IN by) (NP (NP (NN pretreatment)) (PP (IN with) (NP (DT the) (NN _PROT2_) (NN antagonist)))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (DT these) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN 8-OH-DPAT))) (PP (IN on) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN somatostatin)) (CC and) (NP (NN CCK))))))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NN _PROT2_)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ previous) (NNS experiments))) (, ,) (NP (PRP we)) (VP (VBP have) (VP (VBN shown) (SBAR (IN that) (S (PP (VBG following) (NP (NP (NN i.c.v.) (NN application)) (PP (IN of) (NP (NN _PROT1_))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBP are) (VP (VBN increased) (PP (IN through) (NP (DT a) (JJ cholinergic) (NN mechanism))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN influence)) (PP (IN of) (NP (NP (NN myrigalone) (NN B)) (, ,) (NP (NP (DT a) (NN _PROT1_)) (PP (IN from) (NP (NP (DT the) (JJ fruit) (NN exudate)) (PP (IN of) (NP (NNP Myrica) (FW gale) (FW L.)))))))) (PP (IN on) (NP (NP (ADJP (NN Cu) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN oxidation)) (PP (IN of) (NP (NP (JJ low) (NN density) (NN lipoprotein)) (PP (IN from) (NP (NN _PROT2_) (JJ fed) (NNS rabbits)))))))) (VP (VBD was) (VP (VBN investigated))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Immunohistochemical) (NN localization)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (ADJP (ADJP (JJ white)) (CC and) (ADJP (JJ brown))) (NN adipose) (NN tissue)))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB establish) (NP (NP (DT the) (NN cell) (NN type)) (VP (VBG expressing) (NP (NN _PROT1_))))))) (, ,) (NP (PRP we)) (ADVP (RB also)) (VP (VBD assessed) (NP (NP (NP (DT the) (NP (NN size)) (CC and) (NP (NN organization))) (PP (IN of) (NP (NP (NN lipid) (NNS droplets)) (, ,) (NP (NP (DT the) (JJ ultrastructural) (NNS features)) (PP (IN of) (NP (NN mitochondria)))) (, ,)))) (CC and) (NP (NP (DT the) (NP (NN presence)) (CC or) (NP (NN absence))) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (NP (DT a) (JJ brown) (JJ fat-specific) (NN marker))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PP (IN of) (NP (JJ lean) (NNS animals))))) (, ,) (NP (NP (NP (JJ multilocular) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP)) (-RRB- -RRB-))) (JJ -positive) (NN brown) (NNS adipocytes)) (VP (VP (VBD had) (NP (JJ typical) (JJ brown) (NN mitochondria))) (CC and) (VP (VBD were) (ADJP (ADJP (JJ _PROT2_)) (, ,) (CC both) (PP (IN in) (NP (ADJP (ADJP (JJ fed)) (CC and) (ADJP (JJ fasted))) (NNS conditions)))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NP (DT the) (NN periphery)) (PP (IN of) (NP (DT the) (JJ interscapular) (JJ brown) (NN adipose) (NN tissue) (JJ depot))))) (, ,) (S (S (NP (NP (NP (ADJP (ADJP (JJ unilocular)) (, ,) (ADJP (JJ _PROT1_))) (NNS adipocytes)) (PRN (-LRB- -LRB-) (NP (NP (NN mean) (NN diameter)) (: :) (NP (CD 41.55) (NN microns))) (-RRB- -RRB-))) (PP (IN with) (NP (JJ white-type) (NN mitochondria)))) (VP (VBD were) (VP (VBN observed)))) (, ,) (CC and) (S (NP (DT these) (NNS cells)) (VP (VBD were) (NP (JJ _PROT2_))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (ADJP (ADJP (JJ obese)) (PRN (-LRB- -LRB-) (NP (NN db/db)) (-RRB- -RRB-))) (NNS animals))) (, ,) (NP (NN brown) (NN fat)) (VP (VBD was) (VP (VBN composed) (ADVP (RB mainly)) (PP (IN of) (NP (NP (JJ small) (ADJP (ADJP (JJ unilocular)) (, ,) (ADJP (JJ _PROT1_))) (NNS adipocytes)) (PRN (-LRB- -LRB-) (NP (NP (NN mean) (NN diameter)) (: :) (NP (CD 40.08) (NN microns))) (-RRB- -RRB-))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (ADVP (RB also)) (NP (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (JJ classical) (NN brown) (NNS adipocytes)) (VP (VBP differ) (PP (IN from) (NP (JJ white) (NNS adipocytes))) (, ,) (PP (CONJP (RB not) (RB only)) (PP (IN by) (NP (NP (PRP$ their) (NN morphology)) (CC and) (NP (NN _PROT1_) (NN expression)))) (, ,) (CONJP (CC but) (RB also)) (PP (IN by) (NP (NP (PRP$ their) (JJ apparent) (NN lack)) (PP (IN of) (NP (JJ detectable) (NN _PROT2_) (NN expression))))))))) |ET|
-1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (NP (CC or) (NP (NN _PROT2_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT1_)))))) (, ,) (NP (CC or) (NP (NN _PROT_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT2_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (PP (IN During) (NP (NP (NP (NN luteinization)) (PP (IN of) (NP (JJ bovine) (NN granulosa) (NNS cells))) (ADVP (FW in) (FW vitro)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_)))))) (, ,) (NP (CC or) (NP (NN _PROT1_)) (CC plus) (NP (NN forskolin))))) (, ,) (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ massive) (NN upregulation)) (PP (CONJP (RB not) (RB only)) (PP (IN of) (NP (NN progesterone) (NN production))) (, ,) (CONJP (CC but) (RB also)) (PP (IN of) (NP (NP (DT the) (NN gene)) (PP (IN for) (NP (DT the) (NN peptide) (NN hormone) (NN _PROT2_))))) (, ,)) (PP (IN with) (NP (NP (NN secretion)) (PP (IN of) (NP (DT the) (NN peptide))) (PP (IN into) (NP (DT the) (NN medium))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT1_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT1_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT2_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (DT the) (JJ _PROT_) (NN stimulation)) (VP (VBD required) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (NN inhibition)) (VP (VBD was) (ADJP (NN _PROT2_) (JJ independent))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (DT the) (JJ NGF-induced) (NN signaling) (NNS pathways)) (VP (VBG leading) (PP (TO to) (NP (NP (NP (NN inhibition)) (CC and) (NP (NN stimulation))) (PP (IN of) (NP (NN HCO3-) (NN absorption))))))) (VP (VBP are) (NP (JJ distinct)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN HvSPY) (NN coexpression)) (ADVP (RB largely)) (VP (VBD abolished) (NP (NP (JJ _PROT1_) (NN activity)) (PP (IN of) (NP (DT an) (NN _PROT2_) (NN promoter)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Signal) (NN transduction)) (PP (IN of) (NP (NN _PROT1_) (JJ _PROT1_) (JJ arachidonic) (NN acid) (NN release))) (PP (IN in) (NP (NN H9c2) (JJ cardiac) (NNS myoblasts)))) (: :) (NP (NP (NN role)) (PP (IN of) (NP (NN Ca2+)))) (CC and) (NP (NP (DT the) (ADJP (NN _PROT2_) (NN _PROT2_) (JJ _PROT2_)) (NN activation)) (PP (IN of) (NP (NN p42) (JJ mitogen-activated) (NN protein) (NN kinase))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN Ca2+) (NN ionophore)) (, ,) (NP (NP (NN A23187)) (CC or) (NP (NN ionomycin))) (, ,)) (VP (VBD mimicked) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (SBAR (IN whereas) (S (NP (NP (DT the) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activator)) (, ,) (NP (NN TPA)) (, ,)) (ADVP (RB only)) (VP (VBD induced) (NP (NP (DT a) (JJ slight) (NN increase)) (PP (IN in) (NP (NN AA) (NN release)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT1_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT1_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Western) (NNS blots)) (VP (VBD demonstrated) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NN PKCalpha)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (NP (NN delta)) (, ,) (CC and) (NP (NN zeta)))) (PP (IN in) (NP (NN H9c2) (NNS cells)))))) (: ;) (S (NP (NP (NP (NN _PROT_) (NNS inhibitors)) (PRN (-LRB- -LRB-) (NP (NP (NN staurosporine)) (CC or) (NP (NN Ro) (CD 31-8220))) (-RRB- -RRB-))) (CC or) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))) (PP (IN by) (NP (JJ long-term) (PRN (-LRB- -LRB-) (NP (CD 24) (NN h)) (-RRB- -RRB-)) (NN TPA) (NN treatment))))) (VP (VBD caused) (NP (NP (DT a) (JJ partial) (NN blockade)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN response)))) (, ,) (SBAR (IN whereas) (S (NP (DT the) (JJ A23187-induced) (NN AA) (NN release)) (VP (VBD was) (VP (VBN unaffected) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (DT these) (NNS isoforms))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (ADJP (ADJP (JJ _PROT1_)) (CC or) (ADJP (JJ TPA-induced))) (NN activation)) (CC and) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (CD p42) (NN MAPK))))) (VP (VBD were) (VP (ADVP (RB completely)) (VBN blocked) (PP (IN by) (NP (NP (NN down-regulation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta))))))))) (, ,) (CC but) (S (ADVP (RB still)) (VP (VBD occurred) (, ,) (PP (ADVP (RB together)) (IN with) (NP (DT the) (JJ cytosolic) (NN PLA2) (NN mobility) (NN shift))) (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ external) (NN Ca2+))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN AA) (NN release)) (PP (IN in) (NP (NN H9c2) (NNS cells)))) (VP (VBZ is) (ADJP (JJ secondary) (PP (TO to) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN V1) (NN receptor/Gq) (NN protein/PLCP) (NN pathway))))))))) (, ,) (S (VP (VBG leading) (PP (TO to) (NP (NP (NP (DT an) (NN influx)) (PP (IN of) (NP (JJ extracellular) (NN Ca2+)))) (CC and) (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN betaI)) (, ,) (NP (NN epsilon)) (, ,) (CC and) (NP (NN delta)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT1_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT2_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT1_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT2_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN By) (NP (NP (NN comparison)) (PP (IN with) (NP (NP (DT the) (NNS promoters)) (PP (IN of) (NP (NP (NN _PROT_) (NNS genes)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP are) (ADVP (RB also)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT1_))))))))))))) (, ,) (NP (PRP we)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN GARE)) (VP (VBZ is) (VP (VBN coupled) (PP (IN with) (NP (NP (DT the) (JJ upstream) (NN element)) (CC and) (NP (DT the) (NN pyrimidine) (NN box)))) (S (VP (TO to) (VP (VB form) (NP (DT a) (NN _PROT2_) (NN response) (NN complex)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Sympathetic) (NN inhibition)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN subtype) (NN expression)) (PP (IN in) (NP (JJ normal) (JJ fasting) (NNS rats))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB investigate) (NP (NP (JJ neural) (NNS effects)) (PP (IN on) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS UCPs)) (-RRB- -RRB-))))))))) (, ,) (S (NP (PRP we)) (VP (VBD studied) (NP (NP (ADJP (FW in) (FW vivo)) (NNS perturbations)) (VP (VBN intended) (S (VP (TO to) (VP (VB block) (NP (NP (JJ adrenergic) (NN input)) (PP (TO to) (NP (JJ peripheral) (NNS tissues))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT2_)) (, ,) (NP (NN _PROT1_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT_)) (, ,) (NP (NN _PROT1_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT_) (NN mRNA)) (, ,) (CC and) (NP (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN subtype) (NN mRNA))) (PP (IN in) (NP (NP (NNS rats)) (VP (VBN treated) (PP (IN with) (NP (NP (NP (JJ alpha-methyl-p-tyrosine) (NN methyl) (NN ester)) (PRN (-LRB- -LRB-) (NP (NN AMPT-ME)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ inhibits) (NP (NP (NN catecholamine) (NN synthesis)) (CC and) (NP (NP (NN 6-hydroxydopamine)) (PRN (-LRB- -LRB-) (NP (NN 6HDA)) (-RRB- -RRB-)))))))))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (ADJP (JJ toxic) (PP (TO to) (NP (JJ catecholinergic) (NN nerve) (NNS terminals))))) (CC but) (, ,) (PP (IN unlike) (NP (NN AMPT-ME))) (, ,) (VP (VBZ does) (RB not) (VP (VBP enter) (NP (DT the) (JJ central) (JJ nervous) (NN system)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT1_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT2_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT1_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT2_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Intraperitoneal) (NN 6HDA)) (, ,) (NP (CD 100) (NN mg/kg)) (, ,)) (PP (IN as) (NP (NP (DT a) (JJ single) (NN dose)) (PP (IN at) (NP (CD 1800))))) (, ,) (VP (VP (VBD increased) (NP (NP (NN plasma) (NN _PROT_)) (ADJP (RB approximately) (JJ twofold))) (PP (IN after) (NP (CD 18-20) (NN h)))) (, ,) (VP (VBD increased) (NP (NP (NP (NN IBAT)) (-LRB- -LRB-) (CONJP (CC but) (RB not)) (NP (JJ epididymal) (NN fat)) (-RRB- -RRB-)) (NN _PROT1_) (NN mRNA)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold)))) (, ,) (CC and) (VP (VBD decreased) (NP (NN IBAT) (NN _PROT2_) (NN mRNA)) (PP (TO to) (NP (NP (CD 30-40) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NP (DT the) (ADJP (FW in) (FW vivo)) (NN modulation)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VP (VBZ appears) (ADJP (JJ complex))) (CC and) (, ,) (PP (IN beyond) (NP (NP (DT a) (JJ causal) (NN effect)) (PP (IN of) (NP (NN SNA))) (ADVP (FW per) (FW se)))) (, ,) (VP (MD may) (VP (VB depend) (PP (IN on) (NP (NP (JJ concurrent) (NNS changes)) (PP (IN in) (NP (NP (NN plasma) (NN insulin)) (, ,) (NP (NN glucose)) (, ,) (CC and) (NP (JJ circulatory) (NNS hemodynamics))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (SBAR (IN in) (S (NP (NP (NN SN-56/OBR) (NNS cells)) (CC both) (NP (NP (NN CNTF)) (CC and) (NP (NN _PROT1_)))) (VP (VBP produce) (NP (NP (NP (NNS changes)) (PP (IN in) (NP (NN neurotransmitter)))) (CC and) (NP (NP (NN neuropeptide) (NN phenotype) (NN characteristic)) (PP (IN of) (NP (JJ cholinergic) (NNS neurons))))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NN choline) (NN acetyltransferase)) (CC and) (NP (JJ vasoactive) (JJ intestinal) (NN polypeptide))))) (, ,) (CC and) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_) (NN _PROT2_) (NN expression))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (JJ Possible) (NP (NP (JJ central) (JJ nervous) (NN system)) (PRN (-LRB- -LRB-) (NP (NN CNS)) (-RRB- -RRB-))) (NNS mechanisms)) (VP (MD could) (VP (VB mediate) (NP (DT these) (NNS responses)) (PP (IN in) (SBAR (IN that) (S (NP (NN leptin) (NNS receptors)) (VP (VBP are) (ADJP (JJ located) (PP (IN on) (NP (NP (JJ hypothalamic) (NNS neurons)) (SBAR (WHNP (WDT that)) (S (VP (VBP coexpress) (NP (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC or) (NP (NP (NN proopiomelanocortin)) (PRN (-LRB- -LRB-) (NP (JJ POMC)) (-RRB- -RRB-)))) (CC and) (NP (NP (DT both) (NNS peptides)) (SBAR (WHNP (WDT that)) (S (VP (VBP have) (VP (VBN been) (VP (VBN implicated) (PP (IN as) (NP (NP (NNS mediators)) (PP (IN of) (NP (NP (DT the) (NN CNS) (NN action)) (PP (IN of) (NP (NN _PROT2_))))))))))))))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ has) (VP (VBN been) (VP (VBN demonstrated) (S (VP (TO to) (VP (VP (VB decrease)) (CC or) (ADVP (RB down)) (VP (VB regulate) (NP (NN _PROT2_) (NN expression))) (CC and) (VP (VB increase) (NP (JJ POMC) (NN expression))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (CC both) (NP (NN 5-HT)) (CC and) (NP (NN _PROT1_))) (VP (VBP modulate) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NN _PROT2_)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB form) (NP (NP (DT a) (NN part)) (PP (IN of) (NP (NP (DT a) (JJ common) (NN output) (NN pathway)) (PP (IN for) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN appetite))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN studied) (NP (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN neomycin)) (, ,) (NP (NP (DT a) (JJ potent) (NN inhibitor)) (PP (IN of) (NP (NP (JJ inositol) (JJ phospholipid-specific) (NN phospholipase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))) (, ,))) (PP (IN on) (NP (NP (DT the) (NN germination)) (PP (IN of) (NP (NN rice) (NN seed)))))) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN aleurone) (NN layer)) (CC and) (NP (DT the) (JJ scutellar) (NNS tissues)))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBD was) (VP (VBN shown) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (NP (DT the) (NN absence)) (PP (IN of) (NP (JJ exogenous) (NN Ca2+))))) (, ,) (NP (NN neomycin)) (ADVP (RB markedly)) (VP (VP (VBD reduced) (NP (NP (DT the) (NP (NN germination) (NN speed)) (CC and) (NP (JJ seedling) (NN growth))) (PP (IN of) (NP (NN rice) (NNS seeds))))) (CC and) (VP (VBD inhibited) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT both) (JJ secretory) (NNS tissues)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB strongly)) (VP (VBP suggest) (SBAR (IN that) (S (NP (DT the) (NN phosphoinositide-Ca2+) (NN signal) (NN transduction) (NN pathway)) (VP (MD may) (VP (VB play) (NP (DT an) (JJ important) (NN role)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NNS molecules)) (ADJP (RB closely) (JJ related) (PP (TO to) (NP (NP (DT the) (NN germination) (NNS processes)) (PP (IN of) (NP (NN rice) (NN seed))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN C75)) (VP (VP (VBD inhibited) (NP (NP (NN expression)) (PP (IN of) (NP (DT the) (JJ prophagic) (NN signal) (NN _PROT1_) (NN _PROT1_))) (PP (IN in) (NP (DT the) (NN hypothalamus))))) (CC and) (VP (VBD acted) (PP (IN in) (NP (NP (DT a) (JJ _PROT2_) (NN manner)) (SBAR (WHNP (WDT that)) (S (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN by) (NP (NN malonyl-coenzyme) (NN A)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Interactions)) (PP (IN between) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (VP (VBG affecting) (NP (NP (NN lipid) (NN mobilization)) (PP (IN in) (NP (NN adipose) (NN tissue)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT the) (JJ current) (NNS investigations)))) (VP (VBD was) (VP (VBN focused) (PP (IN on) (NP (NP (DT the) (NN study)) (PP (IN of) (NP (NP (DT the) (NN involvement)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NN lipid) (NN mobilization))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ lipolytic) (NN rate)) (VP (VBD was) (VP (VBN assessed) (PP (IN through) (NP (NN glycerol) (NN release))) (PP (IN after) (NP (NP (NN incubation)) (PP (IN with) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN at) (NP (NP (NNS concentrations)) (VP (VBG ranging) (PP (IN from) (NP (NP (NP (NP (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -6)) (-RRB- -RRB-))) (TO to) (NP (CD 10) (PRN (-LRB- -LRB-) (NP (CD -12)) (-RRB- -RRB-)))) (NN M))) (PP (IN in) (NP (NP (VBN isolated) (NNS adipocytes)) (VP (VBN obtained) (PP (IN from) (NP (JJ female) (NNS rats))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NP (JJ equimolar) (NNS concentrations)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (NP (NP (CD 10) (-LRB- -LRB-) (CD -12) (-RRB- -RRB-)) (PP (TO to) (NP (CD 10) (-LRB- -LRB-) (CD -6) (-RRB- -RRB-) (NN M)))) (-RRB- -RRB-)))))) (NP (DT the) (VBN observed) (JJ lipolytic) (NN activity)) (VP (VBZ is) (ADJP (JJ comparable) (PP (TO to) (NP (DT the) (JJ basal) (JJ lipolytic) (NN activity)))) (, ,) (PP (IN except) (PP (IN at) (NP (NP (DT a) (NN concentration)) (PP (IN of) (NP (NP (NP (CD 10)) (PRN (-LRB- -LRB-) (NP (NN -9)) (-RRB- -RRB-))) (NN M)))))) (SBAR (WHADVP (WRB where)) (S (PP (IN upon) (NP (NP (DT a) (JJ significant) (NN increase)) (PP (IN in) (NP (NN lipolysis))))) (VP (VBZ is) (VP (VBN observed)))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBG Summing) (NP (NN up)))) (, ,) (NP (JJ new) (NN evidence)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (MD may) (VP (VB interact) (PP (IN in) (NP (DT a) (JJ homeostatic) (NN loop))) (S (VP (TO to) (VP (VB regulate) (NP (NP (NN body-fat) (NN mass)) (CC and) (NP (NN energy) (NN balance))) (PP (CONJP (RB not) (RB only)) (PP (IN at) (NP (NP (DT the) (JJ central) (JJ nervous) (NN system)) (NN level))) (, ,) (CONJP (CC but) (RB also)) (ADVP (RB directly)) (PP (IN at) (NP (DT the) (JJ adipocyte) (NN level)))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Similarly)) (, ,) (NP (JJ central) (NN _PROT1_) (NN treatment)) (ADVP (RB also)) (VP (VBD had) (NP (DT a) (JJR greater) (NN effect)) (PP (IN in) (S (VP (VBG suppressing) (NP (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NN expression)) (PP (IN in) (NP (ADJP (ADJP (JJ young) (PRN (-LRB- -LRB-) (NP (CD -23+/-4) (NN %)) (-RRB- -RRB-))) (CONJP (IN than) (IN in)) (ADJP (JJ old) (PRN (-LRB- -LRB-) (NP (CD -8+/-4) (NN %)) (-RRB- -RRB-)))) (NNS rats)))))) (PP (VBN compared) (PP (IN with) (NP (PRP$ their) (JJ age-matched) (JJ pair-fed) (JJ treated) (NNS rats))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ relative) (NNS risks)) (PP (IN between) (NP (NP (JJS highest) (CC and) (JJS lowest) (NNS quarters)) (PP (IN of) (NP (NP (NN _PROT1_) (NN intake)) (VP (VBN adjusted) (PP (IN for) (NP (NP (NN age)) (, ,) (NP (NN smoking)) (, ,) (NP (NN serum) (NN _PROT2_) (NN concentration)) (, ,) (NP (NN blood) (NN pressure)) (, ,) (CC and) (NP (NN body) (NN mass) (NN index)))))))))) (VP (VBD were) (NP (NP (NP (CD 0.69)) (PRN (-LRB- -LRB-) (NP (CD 95) (NN %) (NN confidence) (NN interval) (CD 0.53) (TO to) (CD 0.90)) (-RRB- -RRB-))) (CC and) (NP (NP (CD 0.54)) (PRN (-LRB- -LRB-) (NP (CD 0.33) (TO to) (CD 0.87)) (-RRB- -RRB-)))) (PP (IN for) (NP (ADJP (ADJP (JJ total)) (CC and) (ADJP (JJ coronary))) (NN mortality))) (, ,) (ADVP (RB respectively))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Correlation)) (PP (IN between) (NP (NP (DT the) (JJ stimulatory) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (JJ _PROT2_) (NNS _PROT2_)))))))) (CC and) (NP (NP (DT the) (NN oxytocin) (NN receptor) (NN level)) (PP (IN in) (NP (DT the) (JJ pregnant) (NN rabbit) (NN myometrium))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB elucidate) (NP (NP (DT the) (NNS roles)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN oxytocin)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS receptors))) (PP (IN in) (NP (NN rabbit) (NN parturition)))))))) (, ,) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT2_)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN OT) (NN receptor)) (NP (NNS levels)))))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NN rabbit) (NNS myometria))) (PP (PP (IN before)) (CC and) (PP (IN after) (NP (NN parturition)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB elucidate) (NP (NP (DT the) (NNS roles)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN oxytocin)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS receptors))) (PP (IN in) (NP (NN rabbit) (NN parturition)))))))) (, ,) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT_)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN OT) (NN receptor)) (NP (NNS levels)))))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NN rabbit) (NNS myometria))) (PP (PP (IN before)) (CC and) (PP (IN after) (NP (NN parturition)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (SBAR (IN In) (NN order) (S (VP (TO to) (VP (VB elucidate) (NP (NP (DT the) (NNS roles)) (PP (IN of) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN oxytocin)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS receptors))) (PP (IN in) (NP (NN rabbit) (NN parturition)))))))) (, ,) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN _PROT1_)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (DT the) (NN OT) (NN receptor)) (NP (NNS levels)))))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NN rabbit) (NNS myometria))) (PP (PP (IN before)) (CC and) (PP (IN after) (NP (NN parturition)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NP (NN _PROT2_) (NN formation)) (CC and) (NP (NN OT) (NN receptor) (NNS levels))))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NP (DT the) (NNS myometria)) (PP (IN of) (NP (NP (JJ non-pregnant) (NNS rabbits)) (, ,) (NP (NP (NP (NNS Days) (CD 26)) (, ,) (NP (CD 28)) (CC and) (NP (CD 30))) (PP (IN of) (NP (NN pregnancy) (NNS rabbits)))) (, ,) (NP (NP (JJ postpartum) (NNS rabbits)) (PP (IN within) (NP (CD 12) (NNS hours)))) (CC and) (NP (JJ steroid-treated) (JJ ovariectomized) (NNS rabbits)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (S (NP (NN OT) (NNS receptors)) (VP (VBD were) (RB not) (ADJP (JJ detectable) (PP (IN in) (NP (NP (DT the) (NNS myometria)) (PP (IN of) (NP (JJ non-pregnant) (NNS rabbits)))))))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NP (JJ _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IPs)) (-RRB- -RRB-)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN On) (NP (NP (NN Day) (CD 28)) (PP (IN of) (NP (NN pregnancy))))) (, ,) (S (S (NP (NN OT) (NNS receptors)) (VP (VBD became) (ADJP (JJ detectable)))) (, ,) (CC and) (S (ADVP (RB then)) (NP (NN _PROT1_)) (VP (MD could) (VP (VB induce) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NNS _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thereafter)) (, ,) (NP (NP (NP (DT the) (JJ stimulatory) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN _PROT2_) (NN formation)))) (CC and) (NP (DT the) (NN OT) (NN receptor) (NNS levels))) (ADVP (RB dramatically)) (VP (VP (VBD increased) (PP (IN toward) (NP (NP (DT the) (NN end)) (PP (IN of) (NP (NN pregnancy)))))) (CC and) (VP (VBD reduced) (ADVP (RB rapidly)) (PP (IN after) (NP (NN parturition))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT the) (JJ ovariectomized) (JJ pregnant) (NNS rabbits)) (VP (VBD were) (VP (VBN treated) (PP (IN with) (NP (NN estrogen))))))) (, ,) (S (S (NP (NP (NN OT) (NNS receptors)) (PP (IN in) (NP (DT the) (NN myometrium)))) (VP (VBD were) (VP (VBN induced)))) (, ,) (CC and) (S (NP (NN _PROT1_)) (VP (VBD acquired) (NP (DT the) (NN ability) (S (VP (TO to) (VP (VB stimulate) (NP (NN _PROT2_) (NN formation))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (DT an) (JJ OT) (NN receptor) (NN antagonist)) (VP (VBD inhibited) (NP (NP (DT the) (JJ stimulatory) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN _PROT2_) (NN formation))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN by) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (DT the) (NN OT) (NN receptor) (NNS levels)) (PP (IN in) (NP (DT the) (NN myometrium)))) (, ,) (CC and) (NP (NP (DT the) (NN production)) (PP (IN of) (NP (NN PGF2))) (PP (IN in) (NP (DT the) (NN decidua))))))) (VP (MD might) (VP (VB play) (NP (JJ crucial) (NNS roles)) (PP (IN in) (NP (NN parturition)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBZ upregulates) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-2)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (NP (NNS islets)) (PP (IN of) (NP (JJ normal) (NNS rats))))))) (, ,) (CC but) (VP (VBZ has) (NP (DT no) (NN effect)) (PP (IN in) (NP (NP (NNS islets)) (PP (IN of) (NP (JJ obese) (NN Zucker) (JJ Diabetic) (NN Fatty) (-LRB- -LRB-) (NN ZDF) (-RRB- -RRB-) (NNS rats))) (PP (IN with) (NP (VBN mutated) (NN leptin) (NNS receptors))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN 5-HT3) (JJ serotonergic) (NNS receptors))) (PP (IN with) (NP (NP (NN ondansetron)) (PRN (-LRB- -LRB-) (NP (QP (CD 4) (CC or) (CD 8)) (NN mg)) (-RRB- -RRB-))))) (VP (VBD did) (RB not) (VP (VB modify) (NP (NP (NP (DT the) (JJ basal) (NN secretion)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (DT the) (JJ _PROT2_) (NN response)) (PP (TO to) (NP (JJ _PROT_) (NN hypoglycemia))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN 5-HT3) (JJ serotonergic) (NNS receptors))) (PP (IN with) (NP (NP (NN ondansetron)) (PRN (-LRB- -LRB-) (NP (QP (CD 4) (CC or) (CD 8)) (NN mg)) (-RRB- -RRB-))))) (VP (VBD did) (RB not) (VP (VB modify) (NP (NP (NP (DT the) (JJ basal) (NN secretion)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT1_))))) (CC and) (NP (NP (DT the) (JJ _PROT_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN 5-HT3) (JJ serotonergic) (NNS receptors))) (PP (IN with) (NP (NP (NN ondansetron)) (PRN (-LRB- -LRB-) (NP (QP (CD 4) (CC or) (CD 8)) (NN mg)) (-RRB- -RRB-))))) (VP (VBD did) (RB not) (VP (VB modify) (NP (NP (NP (DT the) (JJ basal) (NN secretion)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT_))))) (CC and) (NP (NP (DT the) (JJ _PROT1_) (NN response)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB explore) (NP (NP (DT the) (JJ possible) (NNS roles)) (PP (IN of) (NP (DT the) (JJ hypothalamic) (NN melanocortin) (NN system))) (PP (IN in) (NP (NN _PROT1_) (NN action))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ intracerebroventricular)) (PRN (-LRB- -LRB-) (NP (NN i.c.v.)) (-RRB- -RRB-))) (NN injection)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN with) (CC or) (PP (IN without) (NP (NP (NN SHU9119)) (, ,) (NP (NP (DT a) (JJ potent) (NN antagonist)) (PP (IN of) (NP (JJ alpha-melanocyte) (NN stimulating) (NN hormone)))) (, ,)))))) (PP (IN on) (NP (NP (NP (NN food) (NN intake)) (, ,) (NP (NN body) (NN weight)) (, ,) (CC and) (NP (NP (JJ mitochondrial) (VBG _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-1)) (-RRB- -RRB-))) (NP (NN mRNA) (NN expression))) (PP (IN in) (NP (NP (DT the) (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-)))) (PP (IN in) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB explore) (NP (NP (DT the) (JJ possible) (NNS roles)) (PP (IN of) (NP (DT the) (JJ hypothalamic) (NN melanocortin) (NN system))) (PP (IN in) (NP (NN _PROT1_) (NN action))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ intracerebroventricular)) (PRN (-LRB- -LRB-) (NP (NN i.c.v.)) (-RRB- -RRB-))) (NN injection)) (PP (IN of) (NP (NN _PROT_))) (PP (IN with) (CC or) (PP (IN without) (NP (NP (NN SHU9119)) (, ,) (NP (NP (DT a) (JJ potent) (NN antagonist)) (PP (IN of) (NP (JJ alpha-melanocyte) (NN stimulating) (NN hormone)))) (, ,)))))) (PP (IN on) (NP (NP (NP (NN food) (NN intake)) (, ,) (NP (NN body) (NN weight)) (, ,) (CC and) (NP (NP (JJ mitochondrial) (VBG _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-1)) (-RRB- -RRB-))) (NP (NN mRNA) (NN expression))) (PP (IN in) (NP (NP (DT the) (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-)))) (PP (IN in) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB explore) (NP (NP (DT the) (JJ possible) (NNS roles)) (PP (IN of) (NP (DT the) (JJ hypothalamic) (NN melanocortin) (NN system))) (PP (IN in) (NP (NN _PROT_) (NN action))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ intracerebroventricular)) (PRN (-LRB- -LRB-) (NP (NN i.c.v.)) (-RRB- -RRB-))) (NN injection)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN with) (CC or) (PP (IN without) (NP (NP (NN SHU9119)) (, ,) (NP (NP (DT a) (JJ potent) (NN antagonist)) (PP (IN of) (NP (JJ alpha-melanocyte) (NN stimulating) (NN hormone)))) (, ,)))))) (PP (IN on) (NP (NP (NP (NN food) (NN intake)) (, ,) (NP (NN body) (NN weight)) (, ,) (CC and) (NP (NP (JJ mitochondrial) (VBG _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-1)) (-RRB- -RRB-))) (NP (NN mRNA) (NN expression))) (PP (IN in) (NP (NP (DT the) (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-)))) (PP (IN in) (NP (NNS rats)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ single) (NN i.c.v.) (NN injection)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD decreased) (NP (NP (JJ cumulative) (NN food) (NN intake)) (CC and) (NP (NN body) (NN weight) (NN gain)) (, ,) (CC and) (NP (VBN increased) (NN _PROT2_) (NN mRNA) (NN expression))) (PP (IN during) (NP (CD 3) (NN h))) (PP (IN at) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (DT the) (NN dark) (NN phase)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Co-injection)) (PP (IN of) (NP (NN SHU9119)))) (ADVP (RB also)) (VP (VBD inhibited) (ADVP (RB completely)) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN mRNA) (NN expression))) (PP (IN in) (NP (DT the) (NN BAT))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN established) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN beta) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN AbetaP)) (-RRB- -RRB-))) (VP (VBZ activates) (NP (NP (NP (NN phospholipase) (NN A2)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN phospholipase) (NN D))) (PP (IN of) (NP (NP (NN LA-N-2) (NNS cells)) (CC and) (NP (JJ other) (NN cell) (NNS types))))))))))))) |ET|
+1 |BT| (S1 (S (NP (-LRB- -LRB-) (TO -) (-RRB- -RRB-) (NN Nicotine)) (VP (VBD did) (RB not) (VP (VB blunt) (NP (NP (DT the) (NN _PROT1_) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ specific) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN PKC) (-RRB- -RRB-) (NN inhibitor) (NN chelerythrine)) (PRN (-LRB- -LRB-) (NP (CD 5) (NNS micrometers)) (-RRB- -RRB-))) (VP (VBD inhibited) (NP (NP (NN PTH-)) (, ,) (NP (NN _PROT2_)) (, ,) (NP (NN PGE2-)) (, ,) (CC and) (NP (JJ adenosine-stimulated) (NN Ca2+) (NN reabsorption))) (PP (IN by) (NP (NP (CD 77) (NN %)) (, ,) (NP (CD 67) (NN %)) (, ,) (NP (CD 79) (NN %)) (, ,) (CC and) (NP (CD 100) (NN %)))))) (, ,) (RB respectively))) |ET|
+1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NP (NN PTH)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (NN PGE2)) (, ,) (CC and) (NP (NN adenosine))) (VP (VBP stimulate) (NP (NN Ca2+) (NN reabsorption)) (PP (IN via) (NP (NP (DT a) (NN pathway)) (SBAR (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ independent) (PP (IN of) (NP (NN cAMP))))))) (CC and) (SBAR (WHNP (WDT that)) (S (VP (VBZ involves) (NP (DT a) (ADJP (NN phorbol) (JJ ester-insensitive)) (NN _PROT2_) (NN isotype))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS experiments)) (VP (VBD were) (VP (VBN concluded) (PP (IN by) (S (VP (VBG taking) (NP (NP (NP (NN blood) (NNS samples)) (PP (IN for) (NP (NP (JJ later) (NN analysis)) (PP (IN of) (NP (NN plasma) (NN glucose)))))) (CC and) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (DT the) (JJ following) (NNS hormones)) (: :) (NP (NP (NN _PROT1_)) (, ,) (NP (NN gastrin)) (, ,) (NP (NN CCK)) (, ,) (NP (NN glucagon)) (, ,) (NP (NN somatostatin)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN corticosterone)))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (JJ low-performing) (NN Stock) (NN B) (NNS animals)) (VP (VBD were) (VP (VBN characterized) (PP (IN by) (S (NP (NN [1) (-RRB- -RSB-)) (VP (VBG being) (ADJP (RBR more) (JJ reactive) (PP (TO to) (NP (JJ sensory) (NN stimulation)))))))))) (: :) (NP (NP (JJR higher) (NN startle) (NN amplitude)) (CC and) (NP (JJR shorter) (NN startle) (NN latency))) (: ;) (NP (NP (NP (CD [2) (-RRB- -RSB-)) (VP (VBG having) (NP (NP (NP (JJR higher) (NN plasma) (NN _PROT1_)) (CC and) (NP (NN corticosterone))) (NNS levels)) (, ,) (SBAR (IN whereas) (S (NP (NP (NN plasma) (NN gastrin)) (CC and) (NP (NN _PROT2_))) (VP (VBD were) (ADVP (RB significantly)) (VP (VBN lowered))))))) (CC and) (NP (NP (DT a) (JJ strong) (NN tendency)) (PP (IN for) (NP (NP (DT a) (NN decrease)) (PP (ADVP (RB also)) (IN in) (NP (NN plasma) (NN CCK))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NP (NN G11alpha)) (CC and) (NP (NP (NNS isoforms)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))))) (PP (IN in) (NP (NN islet) (NNS beta-cells)))) (VP (VBZ reveals) (NP (NP (DT a) (NN lack)) (PP (IN of) (NP (NP (NN correlation)) (PP (IN between) (NP (NP (NN inositol) (NN phosphate) (NN accumulation)) (CC and) (NP (NN _PROT2_) (NN secretion))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (PRP It)) (VP (VBZ has) (VP (VBN been) (VP (VBN suggested) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN secretion)) (PP (IN from) (NP (JJ pancreatic) (NNS islets)))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN in) (NP (NN part))) (PP (IN by) (NP (NP (NN activation)) (PP (IN of) (NP (NNS _PROT2_) (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLCs)) (-RRB- -RRB-))) (CC and) (NP (JJ phosphoinositide) (NN hydrolysis)))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN purpose)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB determine) (SBAR (IN whether) (S (NP (NP (DT the) (ADJP (RB relatively) (JJ modest)) (JJ fuel-stimulated) (NN _PROT1_) (NN secretion) (NNS responses)) (PP (IN of) (NP (JJ rodent) (NN beta-cell) (NNS lines)))) (VP (MD might) (VP (VB be) (VP (VBN explained) (PP (IN by) (NP (NP (JJ inadequate) (NP (NN expression)) (CC or) (NP (NN activation))) (PP (IN of) (NP (NN _PROT2_) (NNS isoforms))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Adenovirus-mediated) (NN overexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN -beta1)) (, ,) (CC or) (NP (NN -beta3)))) (PP (IN in) (NP (NN INS-1) (CC or) (NN betaG) (NN 40/110) (NNS cells)))) (VP (VBZ results) (PP (IN in) (NP (NP (ADJP (JJ little))) (CC or) (NP (NP (DT no) (NN enhancement)) (PP (IN in) (NP (NP (JJ inositol) (NN phosphate) (-LRB- -LRB-) (NN IP) (-RRB- -RRB-) (NN accumulation)) (CC and) (NP (NP (DT no) (NN improvement)) (PP (IN in) (NP (NN _PROT2_) (NN secretion))))))))) (SBAR (WHADVP (WRB when)) (S (NP (DT the) (NNS cells)) (VP (VBP are) (VP (VBN stimulated) (PP (IN with) (NP (NP (NN glucose)) (CC or) (NP (NN carbachol)))))))) (, ,) (PP (IN despite) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (VBN overexpressed) (NNS proteins)) (VP (VBP are) (ADJP (RB fully) (JJ active) (PP (IN in) (NP (NN cell) (NNS extracts))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN -beta3)))) (PP (IN in) (NP (JJ normal) (NN rat) (NNS islets)))) (VP (VP (VBZ elicits) (NP (NP (DT a) (JJR larger) (NN increase)) (PP (IN in) (NP (NN IP) (NN accumulation))))) (CC but) (, ,) (ADVP (RB again)) (, ,) (VP (VBZ has) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN _PROT2_) (NN secretion)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (SBAR (IN Because) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN carbachol))) (PP (IN on) (NP (NN _PROT1_) (NN secretion)))) (VP (VBZ is) (VP (VBN thought) (S (VP (TO to) (VP (VB be) (VP (VBN mediated) (PP (IN through) (NP (NP (JJ muscarinic) (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBP link) (PP (TO to) (NP (NP (DT the) (NN Gq/11) (NN class)) (PP (IN of) (NP (JJ heterotrimeric) (NN G) (NNS proteins)))))))))))))))))) (, ,) (NP (PRP we)) (ADVP (RB also)) (VP (VBD overexpressed) (NP (NP (NN G11alpha)) (PP (IN in) (NP (NN INS-1) (NNS cells))) (, ,) (UCP (CC either) (ADVP (RB alone)) (CC or) (PP (IN in) (NP (NP (NN concert)) (PP (IN with) (NP (NP (NN overexpression)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC or) (NP (NN -beta3)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (NP (NP (NN Overexpression)) (PP (IN of) (NP (NN G11alpha)))) (VP (VBZ enhances) (NP (NP (NN IP) (NN accumulation)) (, ,) (NP (NP (DT an) (NN effect)) (VP (ADVP (RB slightly)) (VBN potentiated) (PP (IN by) (NP (NP (NN co-overexpression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC or) (NP (NN -beta3))))))))))) (, ,) (CC but) (S (NP (DT these) (NNS maneuvers)) (VP (VBP do) (RB not) (VP (VB affect) (NP (NP (NN glucose)) (CC or) (NP (JJ carbachol-stimulated) (NN _PROT2_) (NN secretion))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT2_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT2_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT1_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT1_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT1_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT2_) (CC and) (NN _PROT_) (NNS levels))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_))))) (VP (VBD were) (VP (VBN up-regulated) (PP (IN by) (NP (NP (CD 3.2-)) (CC and) (NP (JJ 1.5-fold)))) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN during) (NP (NP (DT the) (JJ late) (NN stage)) (PP (IN of) (NP (NN pregnancy))) (PP (IN with) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (VBD WAT) (NN _PROT_) (NN mRNA) (NN expression)))))))))) (CC and) (S (NP (NP (JJ exogenous) (NN administration)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD resulted) (PP (IN in) (NP (NP (NN induction)) (PP (IN of) (NP (DT the) (NN uterine) (NN _PROT1_) (CC and) (NN _PROT2_) (NNS levels))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT2_)) (CC and) (NP (NN _PROT_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT_) (NNS levels)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT2_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT_) (NNS levels)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT2_) (NNS levels)))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT_) (NNS levels)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT1_)) (CC and) (NP (NN _PROT_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT2_) (NNS levels)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (S (NP (NP (NN _PROT_) (NN gene) (NNS expressions)) (PP (IN during) (NP (NN pregnancy)))) (VP (VBP are) (VP (VBN regulated) (ADVP (RB tissue-dependently))))) (, ,) (CC and) (S (NP (NP (NN up-regulation)) (PP (IN of) (NP (NP (NN uterine) (NN _PROT_)) (CC and) (NP (NN _PROT1_) (NN mRNA))))) (VP (MD may) (VP (VB be) (ADJP (JJ due) (PP (TO to) (NP (VBN increased) (NN _PROT2_) (NNS levels)))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (VBN isolated) (JJ white) (NNS adipocytes))) (, ,) (NP (DT the) (VBN released) (NN adenosine)) (VP (VBZ acts) (PP (IN as) (NP (DT a) (NP (NN helper)) (CC and/or) (NP (NP (DT a) (JJ positive) (NN regulator)) (PP (IN for) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN leptin)))))))) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NP (NN adenosine) (NN A1) (NNS receptors)) (SBAR (WHNP (WDT that)) (S (VP (VBZ involves) (NP (DT the) (JJ _PROT2_) (NN pathway)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ lysophosphatidic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN LPA)) (-RRB- -RRB-)))) (VP (VBP have) (VP (VBN been) (VP (VBN shown) (S (VP (TO to) (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (CC and) (NP (JJ mitogen-activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NNS kinases))) (CC and) (NP (NP (DT the) (NN proliferation)) (PP (IN of) (NP (JJ vascular) (JJ smooth) (NN muscle) (NNS cells))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NP (JJ _PROT1_) (NN activation)) (PP (IN of) (NP (NP (NN RSK2)) (, ,) (NP (NP (DT a) (JJ downstream) (NN substrate)) (PP (IN of) (NP (NP (NN ERK1)) (CC and) (NP (NN ERK2))))) (, ,)))) (VP (VBD was) (UCP (ADJP (JJ _PROT2_)) (CC and) (NP (NN PI) (NN 3-kinase-independent)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD was) (ADJP (JJ necessary)) (PP (PP (IN in) (NP (NN _PROT2_))) (CC but) (PP (RB not) (IN in) (NP (NP (JJ LPA-induced) (NN activation)) (PP (IN of) (NP (NN p70) (NN S6K))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (JJ central) (NNS injections)) (PP (TO to) (NP (JJ intact) (NNS animals)))) (VP (VBD stimulated) (NP (NP (NN _PROT2_) (NN synthesis)) (CC and) (NP (NN secretion))) (PP (IN without) (S (VP (VBG changing) (PP (IN of) (NP (NNS islets) (NN area))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (S (S (NP (NN _PROT1_) (NN administration)) (VP (VBZ stimulates) (NP (NP (NP (NN _PROT2_) (NN synthesis)) (CC and) (NP (NN secretion))) (PP (IN in) (NP (ADJP (ADJP (JJ intact)) (CC and) (ADJP (JJ diabetic))) (NNS animals)))))) (CC and) (S (NP (DT this) (NN effect)) (VP (VBZ is) (ADVP (RBR more)) (VP (VBN expressed) (PP (IN with) (NP (JJ central) (NNS injections))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD reported) (SBAR (SBAR (IN that) (S (NP (NP (NN adiposity)) (CC and) (NP (NN serum) (NN _PROT1_) (NNS levels))) (VP (VBP increase) (PP (IN with) (NP (NN age))) (PP (IN in) (NP (JJ male) (NN F-344xBN) (NNS rats)))))) (CC and) (SBAR (IN that) (S (SBAR (WHADVP (WRB when)) (S (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (NN serum) (NN _PROT2_)))) (VP (VBP are) (VP (VBN manipulated) (PP (IN by) (NP (NN fasting))))))) (, ,) (S (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ corresponding) (JJ reciprocal) (NN change)) (PP (IN in) (NP (NP (NP (JJ hypothalamic) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (JJ young) (NNS rats)))))) (, ,) (CC but) (S (NP (EX there)) (VP (VBP are) (NP (NP (DT no) (NNS changes)) (PP (IN in) (NP (JJR older) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD reported) (SBAR (SBAR (IN that) (S (NP (NP (NN adiposity)) (CC and) (NP (NN serum) (NN _PROT1_) (NNS levels))) (VP (VBP increase) (PP (IN with) (NP (NN age))) (PP (IN in) (NP (JJ male) (NN F-344xBN) (NNS rats)))))) (CC and) (SBAR (IN that) (S (SBAR (WHADVP (WRB when)) (S (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (NN serum) (NN _PROT_)))) (VP (VBP are) (VP (VBN manipulated) (PP (IN by) (NP (NN fasting))))))) (, ,) (S (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ corresponding) (JJ reciprocal) (NN change)) (PP (IN in) (NP (NP (NP (JJ hypothalamic) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (JJ young) (NNS rats)))))) (, ,) (CC but) (S (NP (EX there)) (VP (VBP are) (NP (NP (DT no) (NNS changes)) (PP (IN in) (NP (JJR older) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB previously)) (VP (VBD reported) (SBAR (SBAR (IN that) (S (NP (NP (NN adiposity)) (CC and) (NP (NN serum) (NN _PROT_) (NNS levels))) (VP (VBP increase) (PP (IN with) (NP (NN age))) (PP (IN in) (NP (JJ male) (NN F-344xBN) (NNS rats)))))) (CC and) (SBAR (IN that) (S (SBAR (WHADVP (WRB when)) (S (NP (NP (JJ physiological) (NNS levels)) (PP (IN of) (NP (NN serum) (NN _PROT1_)))) (VP (VBP are) (VP (VBN manipulated) (PP (IN by) (NP (NN fasting))))))) (, ,) (S (S (NP (EX there)) (VP (VBZ is) (NP (NP (DT a) (JJ corresponding) (JJ reciprocal) (NN change)) (PP (IN in) (NP (NP (NP (JJ hypothalamic) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN mRNA))) (PP (IN in) (NP (JJ young) (NNS rats)))))) (, ,) (CC but) (S (NP (EX there)) (VP (VBP are) (NP (NP (DT no) (NNS changes)) (PP (IN in) (NP (JJR older) (NNS rats))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (JJ hypothalamic) (NN _PROT1_) (NN mRNA))) (PP (IN by) (NP (NN _PROT2_)))) (VP (MD may) (VP (VB be) (VP (VBN impaired) (PP (IN with) (NP (NN age))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (NP (NP (NP (JJ daily) (NN food) (NN consumption)) (, ,) (NP (NN body) (NN weight)) (, ,) (NP (NN whole-body) (NN oxygen) (NN consumption)) (, ,) (NP (NN serum) (NN _PROT1_)) (, ,) (CC and) (NP (NN _PROT2_) (NN mRNA))) (PP (IN in) (NP (DT the) (NN hypothalamus))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN infusion)) (VP (VBD diminished) (NP (JJ hypothalamic) (NN _PROT2_) (NNS levels)) (PP (IN by) (NP (QP (RB nearly) (CD 50)) (NN %))) (PP (VBN compared) (PP (IN with) (NP (JJ pair-fed) (JJ young) (NNS rats)))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD were) (NP (DT no) (NNS changes)) (PP (IN in) (NP (NP (DT the) (JJ hypothalamic) (NN _PROT_) (NN mRNA) (NNS levels)) (PP (IN in) (NP (JJ senescent) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT1_) (NN infusion)) (VP (VBD diminished) (NP (JJ hypothalamic) (NN _PROT_) (NNS levels)) (PP (IN by) (NP (QP (RB nearly) (CD 50)) (NN %))) (PP (VBN compared) (PP (IN with) (NP (JJ pair-fed) (JJ young) (NNS rats)))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD were) (NP (DT no) (NNS changes)) (PP (IN in) (NP (NP (DT the) (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NNS levels)) (PP (IN in) (NP (JJ senescent) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN _PROT_) (NN infusion)) (VP (VBD diminished) (NP (JJ hypothalamic) (NN _PROT1_) (NNS levels)) (PP (IN by) (NP (QP (RB nearly) (CD 50)) (NN %))) (PP (VBN compared) (PP (IN with) (NP (JJ pair-fed) (JJ young) (NNS rats)))))) (, ,) (IN whereas) (S (NP (EX there)) (VP (VBD were) (NP (DT no) (NNS changes)) (PP (IN in) (NP (NP (DT the) (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NNS levels)) (PP (IN in) (NP (JJ senescent) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT These) (VBN diminished) (NNS responses)) (PP (TO to) (NP (NN _PROT1_)))) (VP (VP (VBD were) (VP (VBN associated) (PP (IN with)))) (CC and) (VP (MD may) (VP (VB be) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (DT an) (JJ impaired) (NN suppression)) (PP (IN of) (NP (JJ hypothalamic) (NN _PROT2_) (NN mRNA) (NNS levels))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ specific) (NN inhibitor) (CD Go-6983)) (ADVP (RB further)) (VP (VBD enhanced) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (NN VACM-1))) (PP (IN on) (NP (JJ _PROT2_) (NN cAMP) (NN production))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (JJ intracerebroventricular) (NN _PROT1_) (NN infusion))) (PP (IN on) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN expression)) (PP (IN in) (NP (NN rat) (NN muscle)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT1_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT1_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT1_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT2_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN reduction)) (PP (IN of) (NP (NN food) (NN intake))) (VP (VBN imposed) (PP (IN on) (NP (NP (NP (JJ control) (NNS rats)) (PRN (-LRB- -LRB-) (NP (NN pair-feeding)) (-RRB- -RRB-))) (, ,) (VP (VBN aimed) (PP (IN at) (S (VP (VBG mimicking) (NP (JJ _PROT_) (NN hyperphagia)))))) (, ,))))) (VP (VBD produced) (NP (NP (DT a) (JJ marked) (NN decrease)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN muscle) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN UCP-3)) (-RRB- -RRB-))))))) (, ,) (SBAR (IN whereas) (S (NP (NP (NN ICV) (NN infusion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBD prevented) (NP (NP (PDT such) (DT a) (NN decrease)) (PP (IN in) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB substantiate) (NP (NP (DT an) (NN involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN muscle) (NN _PROT2_) (NN expression))))))))) (, ,) (S (NP (JJ hypothyroid) (NNS rats)) (VP (VBD were) (ADVP (RB ICV)) (VP (VBN infused) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (NN vehicle))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB substantiate) (NP (NP (DT an) (NN involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN muscle) (NN _PROT_) (NN expression))))))))) (, ,) (S (NP (JJ hypothyroid) (NNS rats)) (VP (VBD were) (ADVP (RB ICV)) (VP (VBN infused) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (NN vehicle))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB substantiate) (NP (NP (DT an) (NN involvement)) (PP (IN of) (NP (NN thyroid) (NNS hormones))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (NN muscle) (NN _PROT1_) (NN expression))))))))) (, ,) (S (NP (JJ hypothyroid) (NNS rats)) (VP (VBD were) (ADVP (RB ICV)) (VP (VBN infused) (PP (IN with) (NP (NP (NN _PROT2_)) (CC or) (NP (NN vehicle))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP It)) (VP (VBD was) (VP (VBN observed) (SBAR (IN that) (S (PP (IN in) (NP (JJ hypothyroid) (NNS rats))) (, ,) (NP (NN ICV) (NN _PROT1_)) (VP (VBD was) (ADJP (JJ unable) (S (VP (TO to) (VP (VB maintain) (NP (NN muscle) (NN _PROT2_) (NN expression)) (PP (IN at) (NP (NP (NNS values)) (VP (VBN measured) (PP (IN in) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (JJ central) (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN T3) (NN production)) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NN T4))) (PP (TO to) (NP (NN T3) (NN conversion)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (DT this) (NN stimulation)) (VP (MD could) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN on) (NP (NN muscle) (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (JJ central) (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN T3) (NN production)) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NN T4))) (PP (TO to) (NP (NN T3) (NN conversion)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (DT this) (NN stimulation)) (VP (MD could) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT_))) (PP (IN on) (NP (NN muscle) (NN _PROT2_) (NN expression)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (JJ central) (NN _PROT_)) (VP (VBZ stimulates) (NP (NN T3) (NN production)) (PP (IN via) (NP (NP (DT an) (NN activation)) (PP (IN of) (NP (NN T4))) (PP (TO to) (NP (NN T3) (NN conversion)))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (DT this) (NN stimulation)) (VP (MD could) (VP (VB be) (ADJP (JJ responsible) (PP (IN for) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN on) (NP (NN muscle) (NN _PROT2_) (NN expression)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (JJ adult) (NNS rats)))) (VP (VBZ appears) (S (VP (TO to) (VP (VB be) (VP (VBN exerted) (PP (IN at) (NP (JJ hypothalamic) (NN level))) (PP (IN by) (S (VP (VBG regulating) (NP (NP (NP (NP (NN growth) (NN hormone) (VBG releasing) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN GHRH)) (-RRB- -RRB-))) (, ,) (NP (NN somatostatin)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-)))) (VP (VBG -producing) (NP (NNS neurones)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN secretion)) (, ,) (NP (NN inositol) (NN phosphate) (NNS levels)) (, ,) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS isozymes))) (PP (IN in) (NP (JJ rodent) (JJ pancreatic) (NNS islets)))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS findings)) (VP (VBP are) (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (NN concept)) (SBAR (IN that) (S (NP (NP (DT the) (NN underexpression)) (PP (IN of) (NP (DT the) (JJ nutrient-activated) (NN _PROT1_) (NN isozyme)))) (VP (MD may) (VP (VB account) (PP (IN for) (NP (NP (NP (DT the) (JJ minimal) (NN inositol) (NN phosphate)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (CC and) (NP (NN second-phase) (NN _PROT2_) (JJ secretory) (NN response)))) (PP (IN from) (NP (NN mouse) (NNS islets))))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN Gibbestatin) (NN B)) (VP (VBZ inhibits) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NN expression))) (PP (IN in) (NP (JJ cereal) (NN seeds) (NN [In) (NN Process)))))) (S (NP (NNP Citation)) (-RRB- -RSB-)))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (JJ aleurone) (NNS layers)) (PP (IN of) (NP (NN barley)))))) (VP (VBZ is) (VP (VBN known) (S (VP (TO to) (VP (VB be) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_) (CD _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN GA)) (-RRB- -RRB-))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (DT the) (JJ present) (NN study))) (, ,) (NP (NP (NN gibbestatin) (NN B)) (PRN (-LRB- -LRB-) (NP (NN GNB)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN isolated) (PP (IN from) (NP (ADJP (FW Streptomyces) (FW sp.)) (NN C-39))) (PP (IN as) (NP (NP (DT an) (NN inhibitor)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NP (NN barley)) (CC and) (NP (NN rice)))))))))) (, ,) (PP (IN with) (NP (NP (NN IC50) (NNS values)) (PP (IN of) (NP (QP (CD 125) (CC and) (CD 70)) (NN microM))) (, ,) (ADVP (RB respectively))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NN GNB)) (VP (VBD suppressed) (NP (NP (NN accumulation)) (PP (IN of) (NP (NP (NP (JJ _PROT1_) (NN barley) (NN high-pI) (NN type) (NN B)) (CC and) (NP (NN rice) (NN RAmylA) (NN _PROT2_))) (NNS transcripts)))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT These) (NNS analyses)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN GNB)) (VP (VBZ inhibits) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_)))) (PP (PP (IN by) (S (VP (VBG regulating) (NP (NP (CD one)) (PP (IN of) (NP (NP (DT the) (NNS steps)) (VP (VBN involved) (PP (IN in) (NP (NN ABA) (NN signaling)))))))))) (, ,) (CC but) (PP (RB not) (IN by) (S (VP (VBG acting) (PP (IN as) (NP (DT a) (JJ weak) (NN ABA) (NN analog)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NP (NP (JJ _PROT1_) (NN phospholipase) (NN D1)) (CC and) (NP (NN phospholipase) (NN D2))) (NN activity)) (PP (IN in) (NP (JJ human) (JJ embryonic) (NN kidney-293) (NNS cells)))) (VP (VBN mediated) (PP (IN by) (NP (NP (DT the) (NN _PROT2_) (NN _PROT2_)) (CC and) (NP (NN protein) (NN kinase) (NN Calpha) (NN signalling) (NN cascade)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (NN PLD1))) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))) (VP (VBZ has) (NP (DT the) (JJ same) (NN effect)) (, ,) (SBAR (IN while) (S (NP (NP (NN co-expression)) (PP (IN of) (NP (NN PLD2))) (PP (IN with) (NP (NN _PROT2_)))) (VP (VBZ allows) (NP (NN PLD2) (NN activity)) (S (VP (TO to) (VP (VB be) (VP (VBN stimulated) (PP (IN in) (NP (DT an) (JJ _PROT_) (NN manner)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (NN PLD1))) (PP (IN with) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (NN _PROT1_)))) (VP (VBZ has) (NP (DT the) (JJ same) (NN effect)) (, ,) (SBAR (IN while) (S (NP (NP (NN co-expression)) (PP (IN of) (NP (NN PLD2))) (PP (IN with) (NP (NN _PROT_)))) (VP (VBZ allows) (NP (NN PLD2) (NN activity)) (S (VP (TO to) (VP (VB be) (VP (VBN stimulated) (PP (IN in) (NP (DT an) (JJ _PROT2_) (NN manner)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Co-expression)) (PP (IN of) (NP (NN PLD1))) (PP (IN with) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))) (NN _PROT_)))) (VP (VBZ has) (NP (DT the) (JJ same) (NN effect)) (, ,) (SBAR (IN while) (S (NP (NP (NN co-expression)) (PP (IN of) (NP (NN PLD2))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ allows) (NP (NN PLD2) (NN activity)) (S (VP (TO to) (VP (VB be) (VP (VBN stimulated) (PP (IN in) (NP (DT an) (JJ _PROT2_) (NN manner)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ PKC-specific) (NNS inhibitors)) (NP (NP (NN bisindolylmaleimide)) (CC and) (NP (VB Go) (NN 6976)))) (VP (VBP abolish) (NP (JJ _PROT1_) (NN PLD2) (NN activation)) (PP (IN in) (NP (NP (NN HEK-293) (NNS cells)) (VP (VBG co-expressing) (NP (NP (DT the) (NN insulin) (NN receptor)) (, ,) (NP (NP (NN _PROT2_)) (CC and) (NP (NN PLD2))))))) (, ,) (S (VP (VBG confirming) (SBAR (IN that) (S (NP (RB not) (RB only) (NP (NN PLD1)) (, ,) (CC but) (NP (NP (NN PLD2)) (ADVP (RB as) (RB well))) (, ,)) (VP (VBZ is) (VP (VBN regulated) (PP (IN in) (NP (DT a) (JJ PKC-dependent) (NN manner))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NN _PROT1_) (NN treatment)) (VP (VBZ results) (PP (IN in) (NP (NP (NN activation)) (PP (IN of) (NP (CC both) (NP (NN PLD1)) (CC and) (NP (NN PLD2)))) (PP (IN in) (NP (JJ appropriate) (NN cell) (NNS types))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (DT the) (JJ appropriate) (JJ upstream) (NN intermediate) (NN signalling) (NNS components)) (, ,) (PP (FW i.e.) (NP (NP (NN PKCalpha)) (CC and) (NP (NN _PROT2_)))) (, ,)) (VP (VBP are) (VP (VBN expressed) (PP (IN at) (NP (JJ sufficient) (NNS levels))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Hesperidin)) (, ,) (NP (NP (DT the) (ADJP (RBS most) (JJ important)) (NN _PROT1_)) (PP (IN of) (NP (NN Citrus) (CD sp.)))) (, ,)) (ADVP (RB significantly)) (VP (VP (VBZ increases) (NP (NN HDL))) (CC and) (VP (VBZ lowers) (NP (NP (NP (NN _PROT2_)) (, ,) (NP (NN LDL)) (, ,) (NP (JJ total) (NN lipid)) (CC and) (NP (NN triglyceride) (NN plasma) (NNS levels))) (PP (PP (IN in) (NP (JJ normolipidemic) (NNS rats))) (CC and) (PP (IN in) (NP (NP (NNS rats)) (PP (IN with) (NP (ADJP (ADJP (JJ diet-)) (CC and) (ADJP (JJ triton-induced))) (NN hyperlipidemia))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN hCG)) (, ,) (NP (NN hCG)) (CC plus) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN on) (NP (NP (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NNS formations)) (PP (IN in) (NP (NP (NN porcine) (NN myometrial) (NNS cells)) (VP (VBN obtained) (PP (IN from) (NP (ADJP (ADJP (JJ ovariectomized)) (CC and) (ADJP (JJ cyclic))) (NNS gilts))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN hCG)) (, ,) (NP (NN hCG)) (CC plus) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))) (PP (IN on) (NP (NP (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NNS formations)) (PP (IN in) (NP (NP (NN porcine) (NN myometrial) (NNS cells)) (VP (VBN obtained) (PP (IN from) (NP (ADJP (ADJP (JJ ovariectomized)) (CC and) (ADJP (JJ cyclic))) (NNS gilts))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN aim)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD was) (S (VP (TO to) (VP (VB investigate) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN hCG)) (, ,) (NP (NN hCG)) (CC plus) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))) (PP (IN on) (NP (NP (NP (NP (LST (LS [3H) (-RRB- -RSB-)) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NNS formations)) (PP (IN in) (NP (NP (NN porcine) (NN myometrial) (NNS cells)) (VP (VBN obtained) (PP (IN from) (NP (ADJP (ADJP (JJ ovariectomized)) (CC and) (ADJP (JJ cyclic))) (NNS gilts))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJS highest) (NN production)) (PP (IN of) (NP (NP (JJ total) (NN _PROT1_) (NNS _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN d.p.m.)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN found) (PP (IN in) (NP (NP (NNS cells)) (PP (IN from) (NP (NP (JJ ovariectomized) (NNS gilts)) (VP (VP (VBN given) (NP (NP (ADJP (FW in) (FW vivo)) (NN estradiol) (NN benzoate)) (CC and) (NP (NN progesterone))) (PP (IN for) (NP (CD five) (JJ consecutive) (NNS days)))) (CC and) (VP (VBN treated) (PP (IN with) (NP (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC and) (NP (ADJP (CD 100) (NN mU)) (NN hCG))) (CC plus) (NP (NP (ADJP (CD 1) (NN microM)) (NN _PROT2_)) (PRN (-LRB- -LRB-) (QP (QP (CD 984) (CC +/-) (CD 84) (CC and) (CD 1063)) (CC +/-) (QP (QP (CD 131) (CC vs) (CD 314) (CC +/-) (CD 36)) (, ,))) (ADVP (RB respectively)) (-RRB- -RRB-))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
-1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT1_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
-1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (EX There)) (VP (VBD was) (ADVP (RB also)) (NP (NP (DT a) (ADJP (RB very) (JJ significant)) (NN increase)) (PP (IN of) (NP (NN _PROT_)))) (PP (IN after) (NP (NP (DT the) (NN addition)) (PP (IN of) (NP (NP (NP (CD 1000) (NN mU) (NN hCG)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ <) (CD 0.001)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))))))) (SBAR (WHADVP (WRB when)) (S (NP (NP (ADJP (CD 1000) (NN mU)) (NN hCG)) (CC plus) (NP (NN _PROT2_))) (VP (VBD were) (VP (VBN added) (PRN (-LRB- -LRB-) (S (NP (NN p) (NN <) (CD 0.001) (CC and) (NN p)) (VP (JJ <) (NP (CD 0.01)) (, ,) (ADVP (RB respectively)))) (-RRB- -RRB-))))))))) |ET|
+1 |BT| (S1 (S (NP (RB Only) (NN _PROT1_)) (ADVP (RB alone)) (VP (VBD increased) (NP (NP (DT the) (NN formation)) (PP (IN of) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (NNS cells)) (PP (IN from) (NP (NP (JJ ovariectomized) (NNS pigs)) (VP (VBN treated) (PP (IN with) (NP (NN estradiol))) (ADVP (FW in) (FW vivo))))))) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.01)) (-RRB- -RRB-))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT The) (JJS highest) (NN dose)) (PP (IN of) (NP (NN hCG)))) (CC plus) (NP (NP (DT The) (JJS highest) (NN dose)) (PP (IN of) (NP (NP (NN hCG)) (CC plus) (NP (NN _PROT1_)))))) (VP (VBD provoked) (NP (NP (NN accumulation)) (PP (IN of) (NP (NN total) (LST (LS [3H) (-RRB- -RSB-)) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))) (NP (CD 53) (NN %))))) (PP (IN over) (NP (DT the) (JJ basal) (NN level))) (PP (IN on) (NP (NP (NNS days) (NP (CD 21/1))) (PP (IN of) (NP (DT the) (NN estrous) (NN cycle)))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ demonstrates) (SBAR (IN that) (S (NP (NP (NN hCG)) (CC and) (NP (NN _PROT1_))) (VP (MD can) (VP (VB increase) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (JJ _PROT2_) (NNS _PROT2_))) (PP (IN in) (NP (NN porcine) (NN myometrial) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN HVSMC))) (S (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN AVP))) (VP (VBD increased) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN production)) (CC and) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (NN response))))) (, ,) (CC but) (S (NP (NP (DT the) (NN efficacy)) (PP (IN of) (NP (DT the) (NNS responses)))) (VP (VBD was) (ADJP (ADJP (JJR greater)) (PP (IN for) (NP (NN _PROT_))) (PP (IN than) (NP (NN AVP))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN HVSMC))) (S (S (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN AVP))) (VP (VBD increased) (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN production)) (CC and) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (NN response))))) (, ,) (CC but) (S (NP (NP (DT the) (NN efficacy)) (PP (IN of) (NP (DT the) (NNS responses)))) (VP (VBD was) (ADJP (ADJP (JJR greater)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN than) (NP (NN AVP))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN HVSMC))) (S (S (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN AVP))) (VP (VBD increased) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (NN production)) (CC and) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (NN response))))) (, ,) (CC but) (S (NP (NP (DT the) (NN efficacy)) (PP (IN of) (NP (DT the) (NNS responses)))) (VP (VBD was) (ADJP (ADJP (JJR greater)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN than) (NP (NN AVP))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Gamma-aminobutyric) (NN acid) (NN mediation)) (PP (IN of) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (JJ nitric) (NN oxide))) (PP (IN on) (NP (NP (DT the) (NP (NP (NN arginine) (NN vasopressin)) (CC and) (NP (NN _PROT1_))) (NNS responses)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Previous) (NNS studies)) (VP (VBP have) (VP (VBN demonstrated) (SBAR (IN that) (S (NP (DT the) (NP (NP (JJ nitric) (NN oxide)) (PRN (-LRB- -LRB-) (NP (NN NO)) (-RRB- -RRB-))) (NN synthase) (NN inhibitor) (NN L-NAME)) (VP (VBZ exerts) (NP (JJ positive) (NNS effects)) (PP (IN on) (NP (NP (DT the) (NP (NP (NP (NN arginine) (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-)))) (NNS responses)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia))))) (, ,) (S (VP (VBG suggesting) (NP (NP (JJ inhibitory) (NNS actions)) (PP (IN of) (NP (NN NO))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NNP AVP)) (CC and) (NP (NNP _PROT1_))) (JJ secretory) (NNS patterns)) (PP (IN during) (NP (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN 0.15) (NN IU/kg)) (, ,) (NP (NN i.v.))) (-RRB- -RRB-))) (NN -tolerance) (NNS tests)) (PRN (-LRB- -LRB-) (NP (NN ITT)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN examined) (PP (IN in) (NP (NP (CD seven) (JJ normal) (JJ male) (NNS subjects)) (PP (PP (IN with) (S (PRN (-LRB- -LRB-) (NP (JJ experimental) (NNS tests)) (-RRB- -RRB-)))) (CC and) (PP (IN without) (NP (NP (PRN (-LRB- -LRB-) (NP (NN control) (NN test)) (-RRB- -RRB-)) (NP (JJ concomitant) (NN treatment)) (PP (IN with) (NP (NP (NN L-NAME)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 40) (NNS micrograms/kg)) (VP (VBN injected))) (CC plus) (NP (NP (CD 50) (NNS micrograms/kg)) (VP (VBN infused)))) (, ,) (NP (NN i.v.)) (-RRB- -RRB-))))) (, ,) (NP (NP (DT the) (JJ GABAergic) (NN agent) (NN sodium) (NN valproate)) (PRN (-LRB- -LRB-) (NP (NP (NP (CD 600) (NN mg)) (PP (IN in) (NP (CD three) (JJ divided) (NNS doses)))) (ADVP (RB orally))) (-RRB- -RRB-))) (CC or) (NP (NP (DT the) (NN combination)) (PP (IN of) (NP (NP (NN L-NAME)) (CC and) (NP (NN sodium) (NN valproate)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN hypoglycemia)) (VP (VBN increased) (PP (IN by) (NP (NP (ADJP (ADJP (JJ 2-fold)) (PRN (-LRB- -LRB-) (NP (NP (NN peak)) (CC vs.) (NP (NN baseline))) (-RRB- -RRB-))) (NN plasma) (NN AVP)) (CC and) (NP (NN _PROT2_) (NNS levels)))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (NP (NP (NP (DT a) (JJ GABAergic) (NN mediation)) (PP (IN of) (NP (NP (DT the) (JJ inhibitory) (NN modulation)) (PP (IN by) (NP (NN NO))) (PP (IN of) (NP (DT the) (NN AVP)))))) (CC and) (NP (NP (JJ _PROT1_) (NNS responses)) (PP (TO to) (NP (JJ _PROT2_) (NN hypoglycemia)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-)))) (VP (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN glucagon))) (NN release)) (PP (IN from) (NP (DT the) (NN pancreas))))) (, ,) (CC and) (VP (VB evoke) (NP (NP (NN _PROT_) (NN secretion)) (PP (IN from) (NP (NP (DT the) (NN rat) (NN insulinoma) (NN cell) (NN line)) (, ,) (NP (NN RINm5F))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-)))) (VP (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN glucagon))) (NN release)) (PP (IN from) (NP (DT the) (NN pancreas))))) (, ,) (CC and) (VP (VB evoke) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (DT the) (NN rat) (NN insulinoma) (NN cell) (NN line)) (, ,) (NP (NN RINm5F))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (CC and) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-)))) (VP (VP (VB stimulate) (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN glucagon))) (NN release)) (PP (IN from) (NP (DT the) (NN pancreas))))) (, ,) (CC and) (VP (VB evoke) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (DT the) (NN rat) (NN insulinoma) (NN cell) (NN line)) (, ,) (NP (NN RINm5F))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Effects)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN arginine-vasopressin)) (CC and) (NP (NN lysine-vasopressin)))) (PP (IN on) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN glucagon))) (NN secretion)) (PP (IN in) (NP (NN sheep)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NP (DT the) (JJ posterior-pituitary) (NNS peptides)) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (, ,) (NP (NP (NN arginine-vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NP (NN lysine-vasopressin)) (PRN (-LRB- -LRB-) (NP (NN LVP)) (-RRB- -RRB-)))))) (PP (IN on) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN glucagon))) (NN secretion)))) (VP (VBD were) (VP (VBN examined) (PP (IN in) (NP (JJ adult) (NN sheep))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT1_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT1_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT2_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT1_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT2_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT1_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT The) (JJ maximal) (NN _PROT_) (NNS responses)) (VP (VBN induced) (PP (IN by) (NP (NP (NN _PROT_)) (CC and) (NP (NN AVP)))))) (VP (VBD were) (ADJP (RB very) (JJ similar)))) (, ,) (CC but) (S (NP (NP (DT the) (NN threshold)) (CC and) (NP (NP (JJ maximal) (NNS doses)) (PP (IN of) (NP (NN AVP))) (PP (IN for) (S (VP (VBG increasing) (NP (NN plasma) (NN _PROT1_))))))) (VP (VBD were) (ADJP (ADJP (JJR higher)) (PP (IN than) (NP (NP (DT those)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Interleukin-1) (NN beta)) (VP (VBZ inhibits) (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN secretion))) (PP (IN at) (NP (NP (NNS sites)) (PP (ADVP (RB apart)) (IN from) (NP (NN KATP) (NN channel))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Surprisingly)) (, ,) (ADVP (RB however)) (, ,) (SBAR (WHADVP (WRB when)) (S (NP (NNS islets)) (VP (VBD were) (VP (VBN depolarized) (ADVP (RB directly)) (S (VP (VBG using) (NP (NP (DT either)) (PP (IN of) (NP (NP (CD two) (NNS agonists)) (, ,) (NP (NP (NP (NN glyburide)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ does) (RB not) (VP (VB act) (PP (IN via) (NP (NP (NN generation)) (PP (IN of) (NP (NN purine) (NNS nucleotides))))))))) (-RRB- -RRB-)) (CC or) (NP (NP (ADJP (CD 40) (NN mM)) (NN K+)) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (VBZ acts) (ADJP (JJ distal) (PP (TO to) (NP (NN KATP) (NN channel))))))) (-RRB- -RRB-)))))))))))) (, ,) (S (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NN secretion)) (VP (VBD were) (ADVP (RB again)) (VP (VBN obliterated) (PP (IN by) (NP (NN IL-1) (NN beta)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (PRN (-LRB- -LRB-) (ADVP (RB together)) (PP (IN with) (NP (DT the) (NN finding) (SBAR (IN that) (S (NP (NN IL-1) (NN beta)) (VP (VBD inhibited) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN release))))))) (-RRB- -RRB-)) (VP (VBP suggest) (SBAR (IN that) (S (, ,) (PP (IN in) (NP (NP (NN addition)) (PP (TO to) (NP (NP (PRP$ its) (NNS effects)) (PP (PP (IN on) (NP (NN ATP) (NN synthesis))) (CC and) (ADVP (RB thereby)) (PP (IN on) (NP (DT the) (NN KATP) (NN channel)))))))) (, ,) (NP (NN IL-1) (NN beta)) (VP (VBZ has) (NP (QP (IN at) (JJS least) (CD two)) (ADJP (ADJP (JJ undescribed)) (, ,) (ADJP (JJ distal))) (NNS effects)) (PP (TO to) (NP (NP (NN block)) (CC both) (NP (NN _PROT2_)) (CONJP (RB as) (RB well) (IN as)) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN exocytosis)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Association)) (PP (IN of) (NP (DT the) (NN insulin) (NN receptor))) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLCgamma)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ suggests) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (JJ metabolic) (NN signaling)) (PP (IN by) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Association)) (PP (IN of) (NP (DT the) (NN insulin) (NN receptor))) (PP (IN with) (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLCgamma)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ suggests) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT_))) (PP (IN in) (NP (NP (JJ metabolic) (NN signaling)) (PP (IN by) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Association)) (PP (IN of) (NP (DT the) (NN insulin) (NN receptor))) (PP (IN with) (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLCgamma)) (-RRB- -RRB-)))) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ suggests) (NP (NP (DT a) (NN role)) (PP (IN for) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (JJ metabolic) (NN signaling)) (PP (IN by) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT2_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT2_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT2_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT2_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT2_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (JJ functional) (NN significance)) (PP (IN of) (NP (NP (DT the) (NN interaction)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (DT the) (NN IR)))))))))) (, ,) (NP (PRP we)) (VP (VBD used) (NP (NP (NP (NP (DT a) (JJ specific) (NN inhibitor)) (PP (IN of) (NP (NN _PROT_)))) (, ,) (NP (NN U73122)) (, ,)) (CC or) (NP (NP (NN microinjection)) (PP (IN of) (NP (NP (NP (NN SH2) (NN domain) (NN glutathione) (NN S-transferase)) (NN fusion) (NNS proteins)) (VP (VBN derived) (PP (IN from) (NP (NN _PROT1_)))))))) (S (VP (TO to) (VP (VB block) (NP (JJ _PROT2_) (NN GLUT4) (NN translocation)))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (JJ osmotic) (NNS stimuli)) (VP (VBP cause) (NP (NP (NP (DT an) (NN increase)) (PP (IN in) (NP (NP (NP (JJ nitric) (NN oxide) (NN synthase)) (PRN (-LRB- -LRB-) (NP (NN NOS)) (-RRB- -RRB-))) (NN activity)))) (CONJP (RB as) (RB well) (IN as)) (NP (NP (NN synthesis)) (PP (IN of) (NP (NP (NN AVP)) (CC and) (NP (NN _PROT1_)))))) (PP (IN in) (NP (NP (NP (DT the) (NN paraventricular)) (PRN (-LRB- -LRB-) (NP (NN PVN)) (-RRB- -RRB-))) (CC and) (NP (NP (JJ supraoptic) (NNS nuclei)) (PRN (-LRB- -LRB-) (NP (NN SON)) (-RRB- -RRB-)))))))) (, ,) (NP (PRP it)) (VP (VBZ is) (RB not) (VP (VBN known) (SBAR (IN whether) (S (NP (NP (NN NOS) (NN activity)) (PP (IN in) (NP (DT the) (NN hypothalamus)))) (VP (VBZ changes) (PP (IN in) (NP (NP (DT the) (JJ diabetic) (NNS patients)) (SBAR (WHNP (WP who)) (S (VP (VBP have) (NP (NN plasma) (NN hyperosmolality)) (PP (IN with) (NP (NP (NNS hyperglycaemia)) (VP (VBN caused) (PP (IN by) (NP (NN _PROT2_) (NN deficiency)))))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (NP (CD Three) (NNS weeks)) (IN after) (NP (NP (NN administration)) (PP (IN of) (NP (NN STZ))))) (, ,) (NP (DT the) (JJ diabetic) (NNS rats)) (VP (VBD were) (ADVP (RB subcutaneously)) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))) (PP (IN for) (NP (NP (CD 1) (NN week)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD resulted) (PP (IN in) (NP (NP (JJ significant) (NN suppression)) (PP (IN of) (NP (NP (DT the) (NN induction)) (PP (IN of) (NP (NP (NN nNOS)) (, ,) (NP (NN AVP)) (CC and) (NP (NN _PROT2_) (NN gene) (NN expression)))) (PP (IN in) (NP (DT the) (NP (NN PVN)) (CC and) (NP (NN SON))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN mRNA)) (PP (IN in) (NP (NP (NP (JJ white) (NN adipose) (NN tissue)) (CC and) (NP (NP (VBG _PROT2_) (NN _PROT2_) (CD _PROT2_)) (NN mRNA))) (PP (IN in) (NP (JJ skeletal) (NN muscle))))))) (PP (IN during) (NP (NP (DT the) (JJ early) (NNS stages)) (PP (IN of) (NP (NN _PROT_) (NN treatment)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN _PROT1_) (CD _PROT1_) (NN mRNA)) (PP (IN in) (NP (NP (NP (JJ white) (NN adipose) (NN tissue)) (CC and) (NP (NP (VBG _PROT_) (NN _PROT_) (CD _PROT_)) (NN mRNA))) (PP (IN in) (NP (JJ skeletal) (NN muscle))))))) (PP (IN during) (NP (NP (DT the) (JJ early) (NNS stages)) (PP (IN of) (NP (NN _PROT2_) (NN treatment)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Downregulation)) (PP (IN of) (NP (NP (NN _PROT_) (NN _PROT_) (CD _PROT_) (NN mRNA)) (PP (IN in) (NP (NP (NP (JJ white) (NN adipose) (NN tissue)) (CC and) (NP (NP (VBG _PROT1_) (NN _PROT1_) (CD _PROT1_)) (NN mRNA))) (PP (IN in) (NP (JJ skeletal) (NN muscle))))))) (PP (IN during) (NP (NP (DT the) (JJ early) (NNS stages)) (PP (IN of) (NP (NN _PROT2_) (NN treatment)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (PP (IN by) (NP (NP (JJ intravenous) (CC or) (JJ intracerebroventricular) (NN infusion)) (PP (IN for) (NP (CD 5) (NN h)))))) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NP (NP (NN _PROT2_) (NN mRNA)) (PP (IN in) (S (VP (VBD WAT))))) (PRN (-LRB- -LRB-) (NP (CD 47-52) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_) (NN mRNA)) (PP (IN in) (NP (NN SM)))) (PRN (-LRB- -LRB-) (NP (CD 33-37) (NN %)) (-RRB- -RRB-))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_)) (PP (IN by) (NP (NP (JJ intravenous) (CC or) (JJ intracerebroventricular) (NN infusion)) (PP (IN for) (NP (CD 5) (NN h)))))) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NP (NP (NN _PROT_) (NN mRNA)) (PP (IN in) (S (VP (VBD WAT))))) (PRN (-LRB- -LRB-) (NP (CD 47-52) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_) (NN mRNA)) (PP (IN in) (NP (NN SM)))) (PRN (-LRB- -LRB-) (NP (CD 33-37) (NN %)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_)) (PP (IN by) (NP (NP (JJ intravenous) (CC or) (JJ intracerebroventricular) (NN infusion)) (PP (IN for) (NP (CD 5) (NN h)))))) (VP (VBD was) (VP (VBN associated) (PP (IN with) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NP (NP (NN _PROT1_) (NN mRNA)) (PP (IN in) (S (VP (VBD WAT))))) (PRN (-LRB- -LRB-) (NP (CD 47-52) (NN %)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_) (NN mRNA)) (PP (IN in) (NP (NN SM)))) (PRN (-LRB- -LRB-) (NP (CD 33-37) (NN %)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Denervation)) (VP (VP (VBD suppressed) (NP (NP (NN mRNA) (NNS levels)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 49) (NN %)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 36) (NN %)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN COX-IV)) (PRN (-LRB- -LRB-) (NP (CD 59) (NN %)) (-RRB- -RRB-))))))) (CC and) (VP (VBD eliminated) (NP (NP (DT the) (JJ acute) (NN response)) (PP (TO to) (NP (NN _PROT_))) (PP (IN in) (NP (NN SM)))))))) |ET|
-1 |BT| (S1 (S (NP (NN Denervation)) (VP (VP (VBD suppressed) (NP (NP (NN mRNA) (NNS levels)) (PP (IN for) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 49) (NN %)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 36) (NN %)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN COX-IV)) (PRN (-LRB- -LRB-) (NP (CD 59) (NN %)) (-RRB- -RRB-))))))) (CC and) (VP (VBD eliminated) (NP (NP (DT the) (JJ acute) (NN response)) (PP (TO to) (NP (NN _PROT2_))) (PP (IN in) (NP (NN SM)))))))) |ET|
-1 |BT| (S1 (S (NP (NN Denervation)) (VP (VP (VBD suppressed) (NP (NP (NN mRNA) (NNS levels)) (PP (IN for) (NP (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (CD 49) (NN %)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 36) (NN %)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (NN COX-IV)) (PRN (-LRB- -LRB-) (NP (CD 59) (NN %)) (-RRB- -RRB-))))))) (CC and) (VP (VBD eliminated) (NP (NP (DT the) (JJ acute) (NN response)) (PP (TO to) (NP (NN _PROT2_))) (PP (IN in) (NP (NN SM)))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (PRP$ our) (JJ 14C-acetate-labeling) (NNS studies)) (VP (VBD showed) (NP (NP (DT a) (ADJP (CD 50) (NN %)) (NN reduction)) (PP (IN in) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN synthesis)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (DT either) (NN _PROT2_))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD could) (VP (VB account) (PP (IN for) (NP (NP (DT the) (NN reduction)) (PP (IN in) (NP (NP (JJ net) (NN apoB) (NN secretion)) (VP (VBN caused) (PP (IN by) (NP (NP (NN incubation)) (PP (IN with) (NP (DT these) (NNS compounds)))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (DT the) (JJ fluorinated) (NNS analogues)))) (VP (VBD were) (VP (VBN evaluated) (PP (IN on) (NP (NP (NP (NN inhibition)) (PP (IN of) (NP (NN cress) (JJ seed) (NN germination)))) (CC and) (NP (NP (NN inhibition)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN induction)) (PP (IN in) (NP (NN embryoless) (NN barley) (NNS half-seeds)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (-LRB- -LRB-) (NN 2E) (, ,) (NN 4E) (-RRB- -RRB-) (CD -2-Fluoro-5-)) (PRN (-LRB- -LRB-) (NP (NP (NN 1'-hydroxy-2) ('' ')) (, ,) (NP (CD 6) ('' ')) (, ,) (NP (NN 6'-trimethyl-2'-cyclohexen-1'-yl))) (-RRB- -RRB-))) (S (S (NP (NP (JJ -3-methyl-2,4-pentadienoic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN 5b)) (-RRB- -RRB-))) (VP (VBD showed) (NP (JJ potent) (JJ inhibitory) (NN activity)) (PP (IN at) (NP (DT the) (JJ same) (NN level))) (PP (IN as) (NP (NP (NN ABA)) (PP (IN in) (NP (DT the) (NN cress) (JJ seed) (NN germination) (NN test))))))) (, ,) (CC and) (S (NP (NN 5b)) (ADVP (RB also)) (VP (VBD inhibited) (NP (JJ _PROT1_) (NN _PROT2_) (NN induction)) (PP (IN at) (NP (NP (QP (QP (QP (QP (CD 4) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (, ,) (CD 3)) (NNS times)) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN ABA)) (PRN (-LRB- -LRB-) (QP (QP (QP (CD 1) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (-RRB- -RRB-)))) (PP (IN for) (NP (NP (ADJP (CD 50) (NN %)) (NN inhibition)) (PP (IN of) (NP (NN _PROT_) (NN production)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (-LRB- -LRB-) (NN 2E) (, ,) (NN 4E) (-RRB- -RRB-) (CD -2-Fluoro-5-)) (PRN (-LRB- -LRB-) (NP (NP (NN 1'-hydroxy-2) ('' ')) (, ,) (NP (CD 6) ('' ')) (, ,) (NP (NN 6'-trimethyl-2'-cyclohexen-1'-yl))) (-RRB- -RRB-))) (S (S (NP (NP (JJ -3-methyl-2,4-pentadienoic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN 5b)) (-RRB- -RRB-))) (VP (VBD showed) (NP (JJ potent) (JJ inhibitory) (NN activity)) (PP (IN at) (NP (DT the) (JJ same) (NN level))) (PP (IN as) (NP (NP (NN ABA)) (PP (IN in) (NP (DT the) (NN cress) (JJ seed) (NN germination) (NN test))))))) (, ,) (CC and) (S (NP (NN 5b)) (ADVP (RB also)) (VP (VBD inhibited) (NP (JJ _PROT1_) (NN _PROT_) (NN induction)) (PP (IN at) (NP (NP (QP (QP (QP (QP (CD 4) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (, ,) (CD 3)) (NNS times)) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN ABA)) (PRN (-LRB- -LRB-) (QP (QP (QP (CD 1) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (-RRB- -RRB-)))) (PP (IN for) (NP (NP (ADJP (CD 50) (NN %)) (NN inhibition)) (PP (IN of) (NP (NN _PROT2_) (NN production)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (-LRB- -LRB-) (NN 2E) (, ,) (NN 4E) (-RRB- -RRB-) (CD -2-Fluoro-5-)) (PRN (-LRB- -LRB-) (NP (NP (NN 1'-hydroxy-2) ('' ')) (, ,) (NP (CD 6) ('' ')) (, ,) (NP (NN 6'-trimethyl-2'-cyclohexen-1'-yl))) (-RRB- -RRB-))) (S (S (NP (NP (JJ -3-methyl-2,4-pentadienoic) (NN acid)) (PRN (-LRB- -LRB-) (NP (NN 5b)) (-RRB- -RRB-))) (VP (VBD showed) (NP (JJ potent) (JJ inhibitory) (NN activity)) (PP (IN at) (NP (DT the) (JJ same) (NN level))) (PP (IN as) (NP (NP (NN ABA)) (PP (IN in) (NP (DT the) (NN cress) (JJ seed) (NN germination) (NN test))))))) (, ,) (CC and) (S (NP (NN 5b)) (ADVP (RB also)) (VP (VBD inhibited) (NP (JJ _PROT_) (NN _PROT1_) (NN induction)) (PP (IN at) (NP (NP (QP (QP (QP (QP (CD 4) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (, ,) (CD 3)) (NNS times)) (NP (NP (DT the) (NN concentration)) (PP (IN of) (NP (NP (NN ABA)) (PRN (-LRB- -LRB-) (QP (QP (QP (CD 1) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (CC -) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (CD 6)) (-RRB- -RRB-))) (-RRB- -RRB-)))) (PP (IN for) (NP (NP (ADJP (CD 50) (NN %)) (NN inhibition)) (PP (IN of) (NP (NN _PROT2_) (NN production)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN Isolation)) (CC and) (NP (NN characterization))) (PP (IN of) (NP (NP (NN gibbestatin) (NN B)) (, ,) (NP (NP (DT an) (NN inhibitor)) (PP (IN of) (NP (NP (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_)))))) (, ,)))) (CC and) (NP (NP (NN gibbestatin) (NN C)) (PP (IN from) (NP (NNS streptomycetaes))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PRN (-LRB- -LRB-) (QP (CD 1) (CC and) (CD 2)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (VP (VBD were) (VP (VBN determined) (PP (IN by) (NP (NP (NP (JJ reverse) (NN transcription-polymerase) (NN chain) (NN reaction)) (PRN (-LRB- -LRB-) (NP (NN RT-PCR)) (-RRB- -RRB-))) (NN methodology))) (PP (IN in) (NP (NP (JJ adipose) (NN tissue)) (CC and) (NP (JJ gastrocnemius) (NN muscle)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT1_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT1_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT2_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT1_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT2_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT1_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT2_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT1_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT2_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ negative) (NN correlation)) (PP (IN between) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN _PROT_) (NN expression))))))) (VP (VBD was) (VP (VBN found) (PP (PP (IN in) (NP (JJ control) (NNS animals))) (, ,) (CC but) (PP (RB not) (IN in) (NP (DT the) (JJ cafeteria-fed) (NNS groups))))) (, ,) (S (VP (VBG suggesting) (NP (NP (DT a) (JJ differential) (NN response)) (PP (TO to) (NP (NP (DT the) (JJ beta3-adrenergic) (NN compound)) (PP (IN in) (NP (ADJP (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (NNS animals))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VP (VBZ is) (PP (IN in) (NP (NP (NN agreement)) (PP (IN with) (NP (NP (DT the) (VBN reported) (JJ statistical) (NNS interactions)) (PP (IN between) (NP (NP (NP (NN obesity)) (CC and) (NP (NN Trecadrine) (NN administration))) (VP (VBN found) (PP (PP (IN for) (S (VP (VBD WAT) (NP (NP (CD O2) (NN consumption)) (CC and) (NP (NN muscle) (NN _PROT_) (NN expression)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NN plasma) (NN _PROT1_)))))))))))) (CC and) (VP (VBD WAT) (NP (NN _PROT2_) (NN expression)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS aims)) (PP (IN of) (NP (DT this) (NN study)))) (VP (VBD were)) (: :) (LST (-LRB- -LRB-) (LS 1) (-RRB- -RRB-)) (S (S (VP (TO to) (VP (VB assess) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (JJ maternal) (NN undernutrition)) (PP (IN during) (NP (NN pregnancy))))) (PP (IN on) (NP (NP (JJ adult) (NN offspring)) (PP (IN with) (NP (NP (NN regard)) (PP (TO to) (NP (NP (NP (NN growth)) (, ,) (NP (NN body) (NN composition)) (CC and) (NP (NN plasma) (NNS levels))) (PP (IN of) (NP (NP (NN glucose)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN corticosterone)))))))))))))) (, ,) (CC and) (S (LST (-LRB- -LRB-) (LS 2) (-RRB- -RRB-)) (VP (TO to) (VP (VB investigate) (SBAR (IN whether) (S (NP (NP (NN _PROT2_) (NN treatment)) (ADJP (JJ early) (PP (IN in) (NP (NN life))))) (VP (MD could) (VP (VB ameliorate) (NP (NP (DT the) (JJ adverse) (NNS effects)) (PP (IN of) (NP (NN food) (NN restriction)))) (PP (IN in) (NP (NN utero))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NN activity)) (VP (VBD was) (VP (VBN investigated) (PP (IN by) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN membrane) (NNS preparations)) (VP (VBN obtained) (PP (IN from) (NP (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN beta-TC3)) (-RRB- -RRB-)) (: -)) (, ,) (NP (NP (NN somatostatin)) (PRN (-LRB- -LRB-) (NP (NN Rin) (NN 1027-B2)) (-RRB- -RRB-)) (: -)) (, ,) (CC and) (NP (NN glucagon))) (-LRB- -LRB-) (NN INR1-G9) (-RRB- -RRB-) (JJ -producing) (JJ pancreatic) (NN cell) (NNS lines)))))))) (S (VP (VBG using) (NP (NP (NP (DT the) (JJ non-hydrolyzable) (NN GTP) (NN analogue) (NN GTPgammaS)) (ADVP (RB alone))) (, ,) (NP (NP (DT the) (JJ C-terminal) (NN octapeptide) (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK-8)) (-RRB- -RRB-))) (, ,) (CC or) (NP (NN gastrin))))))))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (PRP it)) (VP (VBD was) (VP (VBN examined) (SBAR (IN whether) (S (NP (NP (NN stimulation)) (PP (IN of) (NP (NN Swiss) (NN 3T3) (NNS cells))) (PP (IN with) (NP (NN _PROT1_)))) (VP (VBZ causes) (NP (NP (NNS changes)) (PP (IN in) (NP (NP (NP (DT the) (JJ subcellular) (NN distribution)) (PP (IN of) (NP (NN EGF) (NNS receptors)))) (CC and) (NP (NN _PROT2_) (NN _PROT2_)))) (SBAR (WHNP (WDT that)) (S (VP (MD could) (ADVP (RB potentially)) (VP (VB explain) (NP (DT the) (VBN observed) (NP (NP (NN synergy)) (CC or) (NP (NN costimulation))))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC both) (NP (NN EGF)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADJP (JJ coincident) (PP (IN with) (NP (NP (DT the) (NN EGF) (NN receptor)) (PP (IN in) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (JJ _PROT_) (VBN stimulated) (NNS cells)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC both) (NP (NN EGF)) (CC and) (NP (NN _PROT1_))) (VP (VBD stimulated) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADJP (JJ coincident) (PP (IN with) (NP (NP (DT the) (NN EGF) (NN receptor)) (PP (IN in) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (JJ _PROT2_) (VBN stimulated) (NNS cells)))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC both) (NP (NN EGF)) (CC and) (NP (NN _PROT_))) (VP (VBD stimulated) (NP (NP (DT the) (NN accumulation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADJP (JJ coincident) (PP (IN with) (NP (NP (DT the) (NN EGF) (NN receptor)) (PP (IN in) (NP (NP (DT the) (NN case)) (PP (IN of) (NP (JJ _PROT2_) (VBN stimulated) (NNS cells)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (ADVP (RB Therefore)) (, ,) (NP (PRP it)) (VP (VBZ is) (VP (VBN suggested) (SBAR (IN that) (S (NP (NP (DT the) (JJ _PROT1_) (NN coclustering)) (PP (IN of) (NP (DT the) (NN EGF) (NN receptor))) (PP (IN with) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN at) (NP (DT the) (NN actin) (NN arc)))) (VP (MD may) (VP (VB allow) (PP (IN for) (NP (NP (JJR greater) (NN efficiency)) (PP (IN of) (NP (NN signal) (NN transduction)))))))))) (, ,) (S (VP (VBG resulting) (PP (IN in) (NP (NP (DT the) (NN synergy)) (VP (VBN observed) (PP (IN for) (NP (DT these) (CD two) (NNS hormones))) (PP (IN in) (NP (NP (NN stimulation)) (PP (IN of) (NP (NN DNA) (NN synthesis)))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN For) (NP (NN example))) (, ,) (NP (NN _PROT1_)) (VP (VBZ suppresses) (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN expression)) (PP (IN in) (NP (DT the) (NN arcuate) (NN nucleus))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN Plasma) (NN insulin)) (, ,) (NP (NN cholecystokinin)) (, ,) (NP (NN galanin)) (, ,) (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NNS levels))) (PP (IN in) (NP (JJ obese) (NNS women))) (PP (PP (IN with)) (CC and) (PP (IN without) (NP (NN type) (CD 2) (NN diabetes) (NN mellitus))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Experimental) (NNS studies)) (VP (VBD provided) (NP (NP (NNS evidences)) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NP (NN galanin)) (PRN (-LRB- -LRB-) (NP (NN GAL)) (-RRB- -RRB-))) (, ,) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC and) (NP (NN insulin))) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (JJ feeding) (NN behaviour))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Plasma) (NNS concentrations)) (PP (IN of) (NP (NP (NN FSH)) (, ,) (NP (NP (NN _PROT1_)) (, ,) (NP (NN CCK)) (, ,) (NP (NN GAL)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN insulin)))))) (VP (VBD were) (VP (VBN determined) (S (VP (VBG using) (NP (JJ commercial) (NN RIA) (NNS kits)))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (, ,) (PP (FW ie) (NP (NP (JJR higher) (JJ mean) (NN plasma) (NN _PROT1_) (NNS levels)) (PP (IN in) (NP (NP (JJ postmenopausal) (JJ diabetic) (NNS women)) (CC and) (NP (NP (JJ positive) (NN correlation)) (PP (IN of) (NP (NN CCK))) (PP (IN with) (NP (NP (NN _PROT2_)) (CC and) (NP (NN insulin))))))))) (, ,) (MD may) (VP (VBP suggest) (NP (NP (DT the) (NN role)) (PP (IN of) (NP (DT these) (NNS neuropeptides))) (PP (IN in) (NP (NP (JJ metabolic) (NNS disorders)) (VP (VBG leading) (PP (TO to) (NP (NN type) (CD 2) (NN diabetes) (NN mellitus)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Finally)) (, ,) (NP (JJ recent) (NNS evidences)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NNS melanocortins)) (VP (MD could) (VP (VB be) (VP (VBN involved) (PP (PP (IN in) (S (VP (VBG mediating) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))))))) (, ,) (CC and) (PP (IN in) (S (VP (VBG controlling) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Phosphoinositide) (NN hydrolysis)) (, ,) (VP (VBG resulting) (PP (IN in) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-))) (CC and) (NP (NP (NN diacylglycerol)) (PRN (-LRB- -LRB-) (NP (NN DG)) (-RRB- -RRB-)))) (NN formation)))) (, ,)) (VP (VBZ has) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (JJ _PROT2_) (JJ pulsatile) (NN secretion)) (PP (IN of) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-)))) (PP (IN from) (NP (NP (NN uterine) (NN endometrium)) (PP (IN of) (NP (NP (NN sheep)) (CC and) (NP (JJ other) (NNS mammals))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NP (NN prostaglandin) (NN F2) (NN alpha)) (PRN (-LRB- -LRB-) (NP (NN PGF2) (NN alpha)) (-RRB- -RRB-)))) (PP (IN on) (NP (NP (NP (JJ intracellular) (NN Ca2+) (NN concentration)) (PRN (-LRB- -LRB-) (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN IP)) (-RRB- -RRB-))) (NN generation)) (PP (IN in) (NP (JJ human) (NN myometrial) (NNS cells))))))) (VP (VBD were) (VP (VP (VBN evaluated)) (CC and) (VP (VBN compared) (PP (TO to) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (DT the) (NNS potencies)) (PP (IN of) (NP (NN _PROT1_))) (S (VP (TO to) (VP (VB raise) (NP (NP (NN _PROT2_)) (CC and) (NP (NN [Ca2+) (-RRB- -RSB-) (CD i))))))) (VP (VP (VBD were) (ADJP (ADJP (JJ similar)) (CC and) (ADJP (JJ independent) (PP (IN of) (NP (JJ extracellular) (NN Ca2+)))))) (, ,) (CC and) (VP (MD could) (VP (VB be) (VP (VBN suppressed) (PP (PP (IN by) (NP (NP (NN pertussis) (NN toxin)) (CC and) (NP (NN phorbol) (NN ester)))) (, ,) (CC but) (PP (RB not) (IN by) (NP (NN verapamil)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN action)) (PP (IN of) (NP (NN PGF2) (NN alpha)))) (VP (VBZ depends) (PP (IN on) (NP (JJ extracellular) (NN Ca2+))) (, ,) (SBAR (IN whereas) (S (NP (NN _PROT1_)) (VP (VBZ activates) (NP (NP (DT the) (JJ G-protein-dependent) (NN _PROT2_) (JJ signal-transducing) (NN pathway)) (, ,) (VP (VBN complemented) (PP (IN by) (NP (NP (DT the) (NN influx)) (PP (IN of) (NP (JJ extracellular) (NN Ca2+))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NP (DT the) (NN calcium) (NN response)) (PP (TO to) (NP (NN _PROT1_) (NN application)))) (VP (VBD was) (ADVP (RB principally)) (VP (VBN associated) (PP (IN with) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (NN calcium) (NNS stores)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Homogeneous) (NN liposome) (NN immunoassay)) (PP (IN for) (NP (NN _PROT1_))) (VP (VBG using) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PP (IN from) (NP (NN Clostridium) (NNS perfringens)))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN conjugated) (PP (TO to) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (NP (NP (DT a) (JJ three-step) (NN procedure)) (PP (IN with) (NP (NP (JJ hetero-bifunctional) (NN crosslinking) (NNS reagents)) (, ,) (ADJP (NN succinimidyl) (CD 4-) (-LRB- -LRB-) (NN N-maleimidomethyl) (-RRB- -RRB-) (JJ cyclohexane-1-carboxylate))))) (CC and) (NP (NP (ADJP (CD 3-) (-LRB- -LRB-) (NN 2-pyridyldithio) (-RRB- -RRB-) (JJ propionic)) (NN acid)) (NN N-hydroxysuccinimide) (NN ester)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CC Both) (NP (NN p-nitrophenylphosphatidylcholine) (JJ hydrolytic) (NN activity)) (CC and) (NP (NN liposome) (JJ lytic) (NN activity))) (PP (IN of) (NP (JJ _PROT1_AND_PROT2_) (NN _PROT2_) (NN conjugate)))) (VP (VBD were) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT_) (NN antiserum))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CC Both) (NP (NN p-nitrophenylphosphatidylcholine) (JJ hydrolytic) (NN activity)) (CC and) (NP (NN liposome) (JJ lytic) (NN activity))) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT_) (NN conjugate)))) (VP (VBD were) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_) (NN antiserum))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CC Both) (NP (NN p-nitrophenylphosphatidylcholine) (JJ hydrolytic) (NN activity)) (CC and) (NP (NN liposome) (JJ lytic) (NN activity))) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT1_) (NN conjugate)))) (VP (VBD were) (VP (VBN inhibited) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN _PROT2_) (NN antiserum))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN secretion)) (VP (VBZ is) (VP (VBN regulated) (PP (PP (IN by) (NP (NP (NNS changes)) (PP (IN in) (NP (NN blood) (NN glucose))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NP (NP (NP (NNS peptides)) (PP (IN from) (NP (DT the) (JJ gastrointestinal) (NN tract)))) (CC and) (NP (NNS neurotransmitters))) (SBAR (WHNP (WDT that)) (S (VP (VBP activate) (NP (NP (NP (DT the) (JJ pancreatic) (NN islet) (JJ adenylyl) (NN cyclase)) (PRN (-LRB- -LRB-) (NP (FW e.g.) (, ,) (JJ glucagon-like) (NN peptide-1)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (PP (FW e.g.) (, ,) (NP (NN acetylcholine))) (-RRB- -RRB-))) (NP (NN signaling) (NNS pathways))) (S (VP (TO to) (ADVP (RB further)) (VP (VB potentiate) (NP (JJ glucose-induced) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_) (NN secretion)) (VP (VBZ is) (VP (VBN regulated) (PP (PP (IN by) (NP (NP (NNS changes)) (PP (IN in) (NP (NN blood) (NN glucose))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NP (NP (NP (NNS peptides)) (PP (IN from) (NP (DT the) (JJ gastrointestinal) (NN tract)))) (CC and) (NP (NNS neurotransmitters))) (SBAR (WHNP (WDT that)) (S (VP (VBP activate) (NP (NP (NP (DT the) (JJ pancreatic) (NN islet) (JJ adenylyl) (NN cyclase)) (PRN (-LRB- -LRB-) (NP (FW e.g.) (, ,) (JJ glucagon-like) (NN peptide-1)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (PP (FW e.g.) (, ,) (NP (NN acetylcholine))) (-RRB- -RRB-))) (NP (NN signaling) (NNS pathways))) (S (VP (TO to) (ADVP (RB further)) (VP (VB potentiate) (NP (JJ glucose-induced) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT_) (NN secretion)) (VP (VBZ is) (VP (VBN regulated) (PP (PP (IN by) (NP (NP (NNS changes)) (PP (IN in) (NP (NN blood) (NN glucose))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (NP (NP (NP (NNS peptides)) (PP (IN from) (NP (DT the) (JJ gastrointestinal) (NN tract)))) (CC and) (NP (NNS neurotransmitters))) (SBAR (WHNP (WDT that)) (S (VP (VBP activate) (NP (NP (NP (DT the) (JJ pancreatic) (NN islet) (JJ adenylyl) (NN cyclase)) (PRN (-LRB- -LRB-) (NP (FW e.g.) (, ,) (JJ glucagon-like) (NN peptide-1)) (-RRB- -RRB-))) (CC and) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (PP (FW e.g.) (, ,) (NP (NN acetylcholine))) (-RRB- -RRB-))) (NP (NN signaling) (NNS pathways))) (S (VP (TO to) (ADVP (RB further)) (VP (VB potentiate) (NP (JJ glucose-induced) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (NN leptin)) (VP (VBD did) (VP (VB constrain) (NP (NP (DT the) (VBN enhanced) (JJ _PROT1_) (NN _PROT2_) (NN secretion)) (ADJP (JJ characteristic) (PP (IN of) (NP (NP (NNS islets)) (PP (IN from) (NP (NN ob/ob) (NNS mice))))))) (, ,) (PP (IN without) (S (VP (VBG influencing) (NP (NP (NN release)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (JJ lean) (NNS mice))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ specific) (NN enhancement)) (PP (IN in) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion)))) (VP (VBZ is) (NP (NP (DT the) (JJS earliest) (VBN reported) (JJ developmental) (NN alteration)) (PP (IN in) (NP (NP (NN _PROT_) (NN secretion)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))))))))) (, ,) (CONJP (CC and) (RB thus)) (NP (NP (DT a) (JJ logical) (NN target)) (PP (IN for) (NP (NN leptin) (NN action)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ specific) (NN enhancement)) (PP (IN in) (NP (JJ _PROT1_) (NN _PROT_) (NN secretion)))) (VP (VBZ is) (NP (NP (DT the) (JJS earliest) (VBN reported) (JJ developmental) (NN alteration)) (PP (IN in) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))))))))) (, ,) (CONJP (CC and) (RB thus)) (NP (NP (DT a) (JJ logical) (NN target)) (PP (IN for) (NP (NN leptin) (NN action)))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT A) (JJ specific) (NN enhancement)) (PP (IN in) (NP (JJ _PROT_) (NN _PROT1_) (NN secretion)))) (VP (VBZ is) (NP (NP (DT the) (JJS earliest) (VBN reported) (JJ developmental) (NN alteration)) (PP (IN in) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))))))))) (, ,) (CONJP (CC and) (RB thus)) (NP (NP (DT a) (JJ logical) (NN target)) (PP (IN for) (NP (NN leptin) (NN action)))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (DT This) (NN action)) (PP (IN of) (NP (NN leptin))) (PP (IN on) (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion)))) (VP (VBD was) (ADJP (ADJP (JJ dose-dependent)) (, ,) (ADJP (JJ rapid-onset))) (PRN (-LRB- -LRB-) (PP (FW i.e.)) (, ,) (PP (IN within) (NP (CD 3) (NN min))) (-RRB- -RRB-)))) (, ,) (CC and) (ADVP (JJ reversible)))) |ET|
-1 |BT| (S1 (S (NP (NN Leptin)) (VP (VBD was) (ADJP (RB equally) (JJ effective) (PP (IN in) (S (VP (VBG constraining) (NP (NP (DT the) (VBN enhanced) (NN _PROT1_) (NN release)) (PP (IN from) (NP (NP (NNS islets)) (PP (IN of) (NP (NN ob/ob) (NNS mice))) (VP (VBN caused) (PP (IN by) (NP (NP (NP (NN protein) (NN kinase) (NN C)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NN activation))))))))))) (, ,) (NP (NP (DT a) (JJ downstream) (NN mediator)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN signal) (NN pathway))))))) |ET|
-1 |BT| (S1 (S (NP (NP (CD One) (NN function)) (PP (IN of) (NP (NN leptin))) (PP (IN in) (NP (NP (NN control)) (PP (IN of) (NP (NN body) (NN composition)))))) (VP (VBZ is) (S (ADVP (RB thus)) (VP (TO to) (VP (VB target) (NP (NP (DT a) (JJ PKC-regulated) (NN component)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (NN signaling) (NN system)) (PP (IN within) (NP (NNS islets)))))) (S (VP (TO to) (VP (VB prevent) (NP (NP (NN hypersecretion)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NN brown) (NN fat))) (, ,) (NP (PRP we)) (VP (VBD observed) (NP (NP (DT a) (JJ 2-3-fold) (NN increase)) (PP (IN in) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (JJ dietary) (JJ fat) (NN challenge))))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (TO to) (NP (NP (JJ diet-induced) (NNS elevations)) (PP (IN in) (NP (NN plasma) (NN _PROT2_) (NNS levels)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ evokes) (NP (NP (DT the) (NN release)) (PP (IN of) (NP (NN Ca2+))) (PP (IN from) (NP (JJ _PROT2_) (JJ intracellular) (NNS stores))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (NN barley) (NN gene)) (VP (VBG encoding) (NP (NP (DT a) (JJ novel) (JJ DNA-binding) (NN protein)) (PRN (-LRB- -LRB-) (NP (NN HRT)) (-RRB- -RRB-))))) (VP (VBD was) (VP (VBN identified) (PP (IN by) (NP (NP (NN southwestern) (NN screening)) (PP (IN with) (NP (NP (NNS baits)) (VP (VBG containing) (NP (DT a) (NN _PROT1_) (NN phytohormone) (NN response) (NN element)) (PP (IN from) (NP (DT an) (NN _PROT2_) (NN promoter)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Oxytocin-stimulated) (NN _PROT1_) (NN release)) (PP (IN in) (NP (DT a) (JJ clonal) (NN beta-cell) (NN line) (CD RINm5F)))) (: :) (NP (NP (NN involvement)) (PP (IN of) (NP (ADJP (ADJP (NN _PROT2_) (JJ _PROT2_)) (CC and) (ADJP (JJ -independent))) (NNS pathways)))) (. .)))) |ET|
+1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NN Oxy)) (VP (VBZ increases) (NP (NN _PROT1_) (NN release)) (PP (IN through) (NP (CC both) (NP (NN _PROT2_)) (CC and) (NP (NN non-PLC)) (NP (VBN mediated) (NN signal) (NN transduction) (NNS mechanisms)))))) (. .)))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NN U-73122)) (VP (VBD diminished) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NP (JJ intracellular) (NN concentration)) (PP (IN of) (NP (NN _PROT2_) (CD _PROT2_)))))) (, _PROT2_) (S (NP (NP (CD _PROT2_)) (, _PROT2_) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-)))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT2_))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN insulin) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT_))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN insulin) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN _PROT1_))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN insulin) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN release)) (PP (IN in) (NP (DT a) (JJ clonal) (NN beta-cell) (NN line) (CD RINm5F)))) (: :) (NP (NP (NN involvement)) (PP (IN of) (NP (ADJP (ADJP (NN phospholipase) (JJ C-dependent)) (CC and) (ADJP (JJ -independent))) (NNS pathways))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN AIM)) (: :) (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS mechanisms)) (VP (VBG underlying) (NP (ADJP (NN _PROT1_) (-LRB- -LRB-) (NN Oxy) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN release)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS RESULTS)) (: :) (S (NP (NN _PROT1_)) (VP (VBD increased) (NP (NP (NN _PROT2_) (NN release)) (CC and) (NP (NN [Ca2+) (-RRB- -RSB-) (CD i))) (PP (IN in) (NP (DT a) (JJ concentration-dependent) (NN manner)))))))) |ET|
+1 |BT| (S1 (S (NP (JJ _PROT1_) (NN _PROT2_) (NN release)) (VP (VBD was) (RB not) (VP (VBN altered) (PP (IN by) (NP (NP (NN pretreatment)) (PP (IN with) (NP (NP (NN pertussis) (NN toxin)) (PRN (-LRB- -LRB-) (NP (NN PT)) (-RRB- -RRB-)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN IP3))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT2_) (NN increase)) (PP (IN in) (NP (NN _PROT_) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT1_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN IP3))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN U-73122)) (PP (IN at) (NP (CD 8) (NN mumol.L-1)))) (ADVP (RB totally)) (VP (VBD abolished) (NP (NP (DT the) (JJ _PROT_) (NNS increases)) (PP (IN in) (NP (NP (NN [Ca2+) (-RRB- -RSB-) (CD i)) (CC and) (NP (NN IP3))))))) (: ;) (RB however) (S (NP (PRP it)) (VP (VBD reduced) (NP (NP (DT the) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN _PROT2_) (NN release)))) (PP (ADVP (RB only)) (IN by) (NP (NP (NP (CD 36) (NN %)) (CC and) (NP (CD 63) (NN %))) (PP (IN in) (NP (DT the) (NN monolayer) (CC and) (JJ suspended) (NN cell) (NNS preparations))))) (, ,) (ADVP (RB respectively)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NN _PROT2_) (NN release)) (PP (IN through) (NP (CC both) (NP (NN PLC)) (CC and) (NP (ADJP (NN non-PLC) (JJ mediated)) (NN signal) (NN transduction) (NNS mechanisms))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (VBN isolated) (NNS adipocytes))) (, ,) (NP (NP (DT the) (NN loss)) (PP (IN of) (NP (RB almost) (NN half)))) (S (NP (NP (DT the) (NN 18S) (NN RNA) (NN content)) (PP (IN over) (NP (DT a) (JJ 24-hour) (NN incubation)))) (VP (VBD was) (VP (VBN prevented) (PP (IN in) (DT the) (NN presence) (IN of) (NP (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))) (CC or) (NP (NP (JJ epidermal) (NN growth) (NN factor)) (PRN (-LRB- -LRB-) (NP (NN EGF)) (-RRB- -RRB-)))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Further) (NN investigation)) (VP (VBD suggested) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT2_) (JJ intracellular) (NN signalling) (NN pathway))))))) (, ,)))) (VP (VBZ is) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (DT the) (JJ synergistic) (NN response)))))) (, ,) (SBAR (IN although) (S (NP (PRP it)) (VP (VBZ is) (RB not) (ADJP (JJ obligatory) (PP (IN for) (NP (JJ _PROT_) (NN ACTH) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Further) (NN investigation)) (VP (VBD suggested) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT_) (JJ intracellular) (NN signalling) (NN pathway))))))) (, ,)))) (VP (VBZ is) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (DT the) (JJ synergistic) (NN response)))))) (, ,) (SBAR (IN although) (S (NP (PRP it)) (VP (VBZ is) (RB not) (ADJP (JJ obligatory) (PP (IN for) (NP (JJ _PROT2_) (NN ACTH) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Further) (NN investigation)) (VP (VBD suggested) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (JJ intracellular) (NN signalling) (NN pathway))))))) (, ,)))) (VP (VBZ is) (ADJP (ADJP (JJ necessary)) (CC and) (ADJP (JJ sufficient)) (PP (IN for) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (DT the) (JJ synergistic) (NN response)))))) (, ,) (SBAR (IN although) (S (NP (PRP it)) (VP (VBZ is) (RB not) (ADJP (JJ obligatory) (PP (IN for) (NP (JJ _PROT2_) (NN ACTH) (NN release))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ bovine) (JJ ovarian) (NN granulosa) (NN cell) (NN model)) (VP (VBZ is) (NP (NP (DT a) (JJ primary) (NN culture) (NN system)) (SBAR (WHADVP (WRB where)) (S (PP (IN under) (NP (NP (NN stimulation)) (PP (IN by) (NP (NP (NN _PROT1_)) (CC or) (NP (NP (NN IGF-I)) (CC and) (NP (NN LH))))))) (NP (DT the) (JJ endogenous) (NN _PROT2_) (NN gene)) (VP (VBZ is) (ADVP (RB massively)) (VP (VBN upregulated))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (ADJP (JJ abscisic) (JJ acid-mediated)) (NN inhibition)) (PP (IN of) (NP (JJ _PROT1_) (NNS responses)))) (VP (VBZ seems) (S (VP (TO to) (VP (VB depend) (PP (IN on) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (DT a) (NN phospholipase) (NN D))) (PP (PP (IN during) (NP (NP (NN induction)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NN barley) (NN aleurone) (NNS cells))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN on) (NP (NP (DT a) (JJ putative) (NN acetyltransferase)) (VP (VBN involved) (PP (IN in) (NP (NN elongation) (NN growth))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (NNS Effects)) (PP (IN of) (NP (ADJP (RB intravenously) (VBN infused)) (NN _PROT1_))) (PP (PP (IN on) (NP (NN insulin) (NN sensitivity))) (CC and) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NNS _PROT2_))) (PP (IN in) (NP (JJ brown) (NN adipose) (NN tissue))))))))) |ET|
+1 |BT| (S1 (S (NP (ADJP (RB Centrally) (VBN administered)) (NN _PROT1_)) (VP (VBZ has) (VP (VBN been) (VP (VBN shown) (S (VP (VP (TO to) (VP (VB increase) (NP (JJ insulin-stimulated) (NN glucose) (NN utilization)))) (CC and) (VP (TO to) (VP (VB favor) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NNS UCPs)) (-RRB- -RRB-)))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB study) (SBAR (IN if) (S (NP (NN _PROT1_)) (ADVP (RB also)) (VP (VBZ has) (NP (JJ direct) (ADJP (RB peripherally) (VBN mediated)) (NNS effects)) (PP (IN on) (NP (DT these) (NNS processes))))))))) (, ,) (S (NP (NP (NP (DT this) (NN hormone)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN mg/day)) (-RRB- -RRB-))) (CC or) (NP (PRP$ its) (NN vehicle))) (VP (VBD was) (VP (VBN infused) (PRT (RP i.v.)) (PP (IN for) (NP (NP (CD 4) (NNS days)) (PP (TO to) (NP (JJ lean) (NNS rats)))))))) (CC and) (S (NP (NP (NP (JJ insulin-stimulated) (NN glucose) (NN utilization)) (PP (IN in) (NP (NP (JJ skeletal) (NN muscle)) (CC and) (NP (JJ adipose) (NN tissue))))) (CONJP (RB as) (RB well) (IN as)) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT2_) (NN messenger) (NNS RNAs)) (PRN (-LRB- -LRB-) (NP (NNS mRNAs)) (-RRB- -RRB-)))) (PP (IN in) (NP (JJ brown) (NN adipose) (NN tissue))))) (VP (VBD were) (VP (VBN measured)))))) |ET|
+1 |BT| (S1 (S (S (NP (NN I.v.) (NN _PROT1_) (NN infusion)) (ADVP (RB also)) (VP (VBN favored) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NNS _PROT2_))) (PP (PP (IN in) (NP (JJ brown) (NN adipose) (NN tissue))) (, ,) (CC either) (PP (IN by) (S (VP (VP (VBG increasing) (NP (PRP$ their) (NN expression))) (CC or) (VP (VBG preventing) (S (NP (DT the)) (VP (VBP fall) (VP (VBG occurring) (PP (IN during) (NP (DT the) (JJ pair-feeding) (NN regimen)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT2_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT1_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT2_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT1_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT2_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT1_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
-1 |BT| (S1 (S (S (NP (JJ Relative) (NN _PROT_) (NN expression) (NNS levels)) (VP (VBD were) (NP (NP (QP (CD 100) (, ,) (CD 104) (, ,) (CC and) (CD 33)) (PP (IN for) (NP (NN _PROT_)))) (, ,) (NP (QP (CD 100) (, ,) (CD 191) (, ,) (CC and) (CD 125)) (PP (IN for) (NP (NN _PROT_)))) (CC and) (NP (QP (CD 100) (, ,) (CD 107) (, ,) (CC and) (CD 29)) (PP (IN for) (NP (NN _PROT1_))))) (PP (IN in) (NP (NN ad) (NN libitum) (JJ fed) (NN control) (NNS rats))) (, ,) (PP (PP (IN in) (NP (JJ _PROT2_) (NNS rats))) (CC and) (PP (IN in) (NP (JJ pair-fed) (NN control) (NNS rats)))))) (, ,) (RB respectively))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (DT the) (JJ overall) (NN effect)) (PP (IN of) (NP (NN _PROT1_))) (PP (PP (IN on) (NP (NN glucose) (NN utilization))) (CC and) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NNS _PROT2_))))))) (VP (MD may) (VP (VB be) (VP (VBN mediated) (PP (IN through) (NP (JJ central) (NN mechanism))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN activity)) (PP (IN of) (NP (NN catalase)))) (VP (VBD was) (VP (VBN found) (S (VP (TO to) (VP (VB be) (ADVP (RB significantly)) (VP (VBN enhanced) (PP (IN in) (NP (NP (DT the) (NNS tissues)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ normal)) (CC and) (ADJP (NN _PROT1_) (JJ fed))) (NNS rats)) (VP (VBN administered) (NP (NP (ADJP (CD 1) (NN mg)) (NN _PROT2_)) (PP (IN from) (NP (NN brinjal/100) (NN g) (NN BW/day))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS METHODS)) (: :) (S (NP (PRP We)) (VP (VBP have) (ADVP (RB therefore)) (VP (VBN studied) (NP (NP (NP (NP (JJ possible) (NNS associations)) (PP (IN of) (NP (DT the) (NN Gln27Glu)))) (CC and) (NP (NP (DT the) (NN Gly16Arg) (NNS polymorphisms)) (PP (IN in) (NP (NP (DT the) (NN beta2AR)) (PP (IN with) (NP (NN BMI))))))) (, ,) (NP (NP (NN plasma) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN mRNA) (NN expression)))) (PP (IN in) (NP (NP (DT the) (JJ intraperitoneal) (NN adipose) (NN tissue)) (PP (IN in) (NP (NP (DT a) (NN population)) (PP (IN of) (NP (NN Caucasian) (NNS women))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (DT no) (NN association)) (VP (VBD was) (VP (VBN found) (PP (IN between) (NP (NP (DT the) (NP (NP (NN Gln27Glu)) (CC or) (NP (DT the) (NN Gly16Arg))) (NNS polymorphisms)) (CC and) (NP (NP (NN plasma) (NN _PROT1_)) (CC or) (NP (NN adipose) (NN tissue)) (NP (NN _PROT2_) (NN gene) (NN expression))))) (PP (IN in) (NP (DT either) (NN group))))))) |ET|
-1 |BT| (S1 (S (NP (NP (ADJP (FW In) (FW vivo)) (NNS effects)) (PP (IN of) (NP (NN CGP-12177))) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_) (NNS genes)))) (PP (IN in) (NP (NN mouse) (ADJP (ADJP (JJ brown)) (CC and) (ADJP (JJ white))) (NN adipose) (NNS tissues)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (NN effect)) (PP (PP (IN of) (NP (NP (JJ chronic) (NN treatment)) (PP (IN with) (NP (NP (CD CGP-12177)) (NP (DT a) (JJ beta3-adrenergic) (NN receptor) (-LRB- -LRB-) (NN AR) (-RRB- -RRB-) (NN agonist)))) (PP (IN with) (NP (JJ beta2/beta1-AR) (NN antagonist) (NN action))))) (, ,) (PP (IN on) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene))))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (VP (VBG coding) (PP (IN for) (NP (NP (NN _PROT2_) (NNS _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (NN ucp1)) (, ,) (NP (NN ucp2)) (CC and) (NP (NN ucp3))) (-RRB- -RRB-)))))))) (PP (IN in) (NP (ADJP (ADJP (JJ brown)) (CC and) (ADJP (JJ white))) (NN adipose) (NNS tissues)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT1_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT2_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT1_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT1_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT1_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT2_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT1_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN CONCLUSION)) (: :) (S (NP (DT The) (NNS results)) (VP (VP (VBP reveal) (SBAR (IN that) (S (NP (NP (JJ simultaneous) (NN stimulation)) (PP (IN of) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (JJ certain) (NN _PROT_) (NNS genes)) (CC and) (NP (DT the) (NN _PROT_) (NN gene))))))) (VP (MD can) (VP (VB be) (VP (VBN achieved))))))) (, ,) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ adrenergic) (NN regulation)) (PP (PP (IN of) (NP (DT the) (NN _PROT1_) (NN gene))) (CC and) (PP (IN of) (NP (NP (NNS genes)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN family)) (PP (IN in) (NP (JJ adipose) (NNS tissues))))))))) (VP (VBZ is) (NP (NP (DT the) (NN result)) (PP (IN of) (NP (NP (JJ complex) (NNS interactions)) (PP (IN between) (NP (DT the) (JJ different) (JJ beta-AR) (NNS pathways))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (NP (CC neither) (NP (NN progesterone)) (CC nor) (NP (NN _PROT1_))) (VP (VBD increased) (NP (NP (NN phosphotyrosine)) (PP (IN on) (NP (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT1_AND_PROT2_)) (: :) (NP (NP (JJ opposing) (NNS effects)) (PP (IN on) (NP (NP (ADJP (ADJP (JJ appetitive)) (CC and) (ADJP (JJ consummatory))) (NN ingestive) (NN behavior)) (CC and) (NP (JJ sexual) (NN behavior)))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Many) (NNS studies)) (VP (VBP have) (VP (VBN indicated) (SBAR (IN that) (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (VP (VBZ stimulates))) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ inhibits) (NP (NN food) (NN intake)))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NP (NN line)) (PP (IN with) (NP (DT this))))) (, ,) (NP (NP (JJ intracerebroventricular) (NN injection)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (CD 10) (NN microg)) (-RRB- -RRB-))))) (VP (VBD stimulated))) (S (CC and) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 10) (NN microg)) (-RRB- -RRB-))) (VP (VBD inhibited) (NP (NP (NN intake)) (PP (IN of) (NP (DT a) (NN sucrose) (NN solution)))) (SBAR (WHADVP (WRB when)) (S (NP (JJ female) (NNS rats)) (VP (VBD were) (VP (VBN required) (S (VP (TO to) (VP (VB obtain) (NP (DT the) (NN solution)) (PP (IN from) (NP (DT a) (JJ bottle)))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB However)) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBD inhibited))) (CC and) (S (NP (NN _PROT2_)) (VP (VBD stimulated) (NP (NN intake)) (SBAR (IN if) (S (NP (DT the) (NN solution)) (VP (VBD was) (VP (VBN infused) (ADVP (RB intraorally))))))))))) |ET|
-1 |BT| (S1 (S (S (ADVP (RB Thus)) (NP (NN _PROT1_)) (VP (VP (VBZ stimulates) (NP (NP (DT the) (NNS responses)) (VP (VBN used) (S (VP (TO to) (VP (VB obtain) (NP (NN food)))))))) (CC but) (VP (VBZ inhibits) (NP (NP (DT those)) (VP (VBN used) (S (VP (TO to) (VP (VB consume) (NP (NN food)))))))))) (, ,) (CC and) (S (NP (NN _PROT2_)) (VP (VBZ has) (NP (DT the) (JJ opposite) (NNS effects)))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (ADVP (RB also)) (VP (VBD determined) (SBAR (IN whether) (S (NP (NP (ADJP (RB well) (JJ known)) (JJ hypothalamic) (NN neuropeptide) (NNS targets)) (, ,) (PP (FW e.g.) (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NP (NN proopiomelanocortin)) (PRN (-LRB- -LRB-) (NP (JJ POMC)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ agouti-related) (NN peptide)) (PRN (-LRB- -LRB-) (NP (NN AGRP)) (-RRB- -RRB-))) (CC and) (NP (NP (NN cocaine)) (CC and) (NP (NP (JJ amphetamine-regulated) (NN transcript)) (PRN (-LRB- -LRB-) (NP (NN CART)) (-RRB- -RRB-))))))) (VP (VBD were) (VP (VBN regulated) (PP (IN in) (NP (NP (DT a) (NN pattern)) (ADJP (JJ consistent) (PP (IN with) (NP (PRP$ their) (JJ presumed) (NNS roles)))))) (PP (IN as) (NP (NP (NNS mediators)) (PP (IN of) (NP (NN _PROT2_) (NN action)))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBD decreased) (NP (NP (NN body) (NN weight)) (CC and) (NP (NN adiposity)))) (, ,) (VP (VBD increased) (NP (NN CART))) (CC and) (VP (VBD suppressed) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN AGRP))) (NN mRNA) (NN expression)) (PP (IN in) (NP (JJ adult) (NNS mice)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (JJ _PROT1_) (NN beta) (NN protein)) (PRN (-LRB- -LRB-) (NP (CD 25-35)) (-RRB- -RRB-))) (NN stimulation)) (PP (IN of) (NP (NP (NP (NP (NN _PROT2_) (NN A)) (, ,) (NP (NN C)) (CC and) (NP (NN D))) (NNS activities)) (PP (IN of) (NP (NN LA-N-2) (NNS cells)))))))) |ET|
-1 |BT| (S1 (S (LST (LS [3H) (-RRB- -RSB-)) (S (S (NP (NN Inositol) (JJ prelabeled) (NN LA-N-2) (NNS cells)) (VP (VBD were) (VP (VBN exposed) (PP (TO to) (NP (NP (JJ varying) (NNS concentrations)) (PP (IN of) (NP (DT _PROT1_) (NN _PROT1_) (NN _PROT1_))))) (, ,) (PP (IN from) (NP (QP (CD 20) (TO to) (CD 125)) (NNS micrograms/ml)))))) (, ,) (CC and) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activation)) (VP (VBD was) (VP (VBN measured))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (JJ adrenergic) (, ,) (NP (NP (JJ metabotropic) (NN amino) (NN acid)) (CC and) (NP (NN bombesin))) (NNS antagonists))) (PP (IN on) (NP (NP (DT the) (ADJP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (JJ mediated)) (NN stimulation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN activity)))))) (VP (VBD was) (VP (VBN investigated))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Propranolol)) (, ,) (NP (NP (DT a) (NN beta) (JJ adrenergic) (NN antagonist)) (, ,) (NP (JJ 7-chloro-kynurenic) (NN acid))) (, ,) (NP (DT a) (JJ metabotropic) (NN amino) (NN acid) (NN antagonist)) (, ,) (CC and) (NP (NN [Tyr4-D-Phe12)) (-RRB- -RSB-) (NP (NN bombesin)) (, ,) (NP (DT a) (NN bombesin) (NN antagonist)) (, ,)) (VP (VBD blunted) (NP (NP (DT the) (NN _PROT1_) (NN _PROT1_) (NN _PROT1_) (NN stimulation)) (PP (IN of) (NP (NP (NN _PROT2_) (NN _PROT2_)) (NN activity))) (PP (IN in) (NP (LST (LS [3H) (-RRB- -RSB-)) (NN inositol)))))) (NP (JJ prelabeled) (NN LA-N-2) (NNS cells)))) |ET|
+1 |BT| (S1 (S (NP (DT This)) (VP (VBZ suggests) (SBAR (IN that) (S (NP (NP (JJ _PROT1_) (NN beta) (NN protein) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_)))) (VP (MD may) (VP (VB be) (NP (NP (NN receptor)) (VP (VBN mediated)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN inhibitor)) (NP (NN U) (NN 71322))) (VP (VBD prevented) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN by) (NP (DT _PROT_) (NN _PROT_) (NN _PROT_))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NN _PROT1_) (NN inhibitor)) (NP (NN U) (NN 71322))) (VP (VBD prevented) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_))) (PP (IN by) (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT_) (NN _PROT_) (NN inhibitor)) (NP (NN U) (NN 71322))) (VP (VBD prevented) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (PP (IN by) (NP (DT _PROT2_) (NN _PROT2_) (NN _PROT2_))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN secretion)) (CC and) (NP (NP (DT _PROT2_) (NN _PROT2_) (NN production)) (PP (IN in) (NP (NN NT2N) (NNS neurons))))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (DT the) (NN _PROT_) (NN _PROT_) (NN signal) (NN transduction) (NN pathway)))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT1_) (NN secretion)) (CC and) (NP (NP (DT _PROT_) (NN _PROT_) (NN production)) (PP (IN in) (NP (NN NT2N) (NNS neurons))))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN signal) (NN transduction) (NN pathway)))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (NN _PROT_) (NN secretion)) (CC and) (NP (NP (DT _PROT1_) (NN _PROT1_) (NN production)) (PP (IN in) (NP (NN NT2N) (NNS neurons))))) (VP (VBP are) (VP (VBN regulated) (PP (IN by) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN signal) (NN transduction) (NN pathway)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Current) (NN interest)) (PP (IN in) (NP (NN reducing) (NN heart) (NN disease) (NNS risks))) (PP (IN by) (NP (NN diet)))) (VP (VBZ involves) (NP (NP (NN attention)) (PP (TO to) (NP (JJ total) (NN fat)))))) (: ;) (S (NP (NP (ADJP (ADJP (JJ saturated)) (, ,) (ADJP (JJ monounsaturated)) (, ,) (ADJP (JJ polyunsaturated)) (CC and) (ADJP (JJ trans))) (JJ fatty) (NNS acids)) (, ,) (CONJP (RB as) (RB well) (IN as)) (NP (NP (JJ dietary) (NN _PROT1_)) (, ,) (NP (JJ soluble) (NN fiber)) (, ,) (NP (NN salt)) (, ,) (NP (NN alcohol))) (, ,) (NP (NNS antioxidants)) (, ,) (NP (JJ dietary) (NNS alterations))) (VP (VBG causing) (NP (NP (NP (NN homocysteinemia)) (CC and) (NP (JJ other) (JJ dietary) (NNS constituents))) (, ,) (NP (ADJP (JJ such) (PP (IN as) (NP (NP (NN _PROT2_) (NNS compounds)) (PP (IN in) (NP (DT some) (NN soy)))))) (NNS products))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ cAMP-dependent) (NN phosphorylation)) (PP (IN at) (NP (NP (DT a) (NN step)) (VP (VBG involving) (NP (JJ GTP-binding) (NN protein/PLC) (NN coupling)))))) (VP (MD can) (VP (VP (VB exert) (NP (DT a) (JJ negative) (NN effect)) (PP (IN on) (NP (NP (DT the) (NN stimulation)) (PP (IN of) (NP (NN _PROT1_) (NN formation))) (PP (IN by) (NP (NN _PROT2_)))))) (CC and) (RB thereby) (VP (VB affect) (NP (NP (NN contraction/relaxation)) (PP (IN in) (NP (DT the) (NN myometrium)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Roles)) (PP (IN of) (NP (NP (NN GTP)) (CC and) (NP (NN _PROT1_) (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))) (PP (IN by) (NP (NN glucose))) (PP (IN in) (NP (NN rat) (JJ pancreatic) (NNS islets)))))))) |ET|
-1 |BT| (S1 (S (S (NP (EX There)) (VP (VBD was) (NP (NP (DT a) (ADJP (NP (CD 98) (NN %)) (JJR greater)) (NN augmentation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))) (PP (IN by) (NP (ADJP (CD 16.7) (NN mM)) (NN glucose)))) (-LRB- -LRB-) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NP (NN diazoxide)) (CC and) (NP (ADJP (CD 40) (NN mM)) (NN K+)))))) (-RRB- -RRB-) (PP (IN in) (NP (JJ primed) (NNS islets))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (DT the) (NN ability)) (PP (IN of) (NP (JJ high) (NN glucose))) (S (VP (TO to) (VP (VB augment) (NP (NN _PROT2_) (NN activity)))))) (VP (VBD bore) (NP (DT no) (NN relationship)) (PP (TO to) (NP (DT the) (JJ secretory) (NN response))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN MPA)) (ADVP (RB markedly)) (VP (VBD inhibited) (NP (NN _PROT1_)) (PP (IN in) (NP (DT both) (NNS conditions))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (NN _PROT2_) (NN secretion)) (VP (VBD was) (ADVP (RB only)) (VP (VBN inhibited) (PRN (-LRB- -LRB-) (PP (IN by) (NP (CD 46) (NN %))) (-RRB- -RRB-)) (PP (IN in) (NP (JJ primed) (NNS islets)))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT2_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT2_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT1_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT2_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT1_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VBP indicate) (SBAR (SBAR (IN that) (S (NP (NP (DT an) (JJ adequate) (NN level)) (PP (IN of) (NP (NN GTP)))) (VP (VBZ is) (ADJP (JJ critical) (PP (IN for) (NP (NP (NN glucose) (POS 's) (NN potentiation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT_) (NN secretion))) (PP (IN in) (NP (JJ primed) (NNS islets))))))))) (CC but) (SBAR (IN that) (S (NP (NN _PROT_) (NN activation)) (VP (VP (MD can) (ADVP (RB clearly)) (VP (VB be) (VP (VBN dissociated) (PP (IN from) (NP (NN _PROT1_) (NN secretion)))))) (CC and) (ADVP (RB therefore)) (VP (MD cannot) (VP (VB be) (NP (NP (DT the) (JJ major) (NN cause)) (PP (IN of) (NP (NP (NN glucose) (POS 's) (NN augmentation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -induced)) (NN _PROT2_) (NN secretion))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Regulation)) (PP (IN of) (NP (NN _PROT1_) (NN secretion))) (PP (IN via) (NP (NP (JJ ATP-sensitive) (NN K+) (NN channel)) (JJ independent) (NNS mechanisms)))) (: :) (NP (NP (NN role)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ further) (NN addition)) (PP (IN of) (NP (NP (NP (NN carbachol)) (, ,) (NP (NP (DT an) (NN agonist)) (SBAR (WHNP (WDT that)) (S (VP (VBZ activates) (NP (NP (DT an) (NN isozyme)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_))) (ADJP (JJ distinct) (PP (IN from) (NP (NP (DT that)) (VP (VBN activated) (PP (IN by) (NP (NN glucose)))))))) (, ,) (PP (ADVP (RB together)) (IN with) (NP (NN K+)))))))) (, ,) (NP (ADJP (CD 20) (NN mM)) (NN glucose)) (, ,) (CC plus) (NP (NN diazoxide))))) (VP (VBD resulted) (PP (IN in) (NP (NP (DT a) (JJ sustained) (NN amplification)) (PP (IN of) (NP (NP (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NP (NP (NN mouse)) (CONJP (CC but) (RB not)) (NP (NN rat))) (NNS islets)))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NN inability) (S (VP (TO to) (VP (VB activate) (NP (NP (DT a) (ADJP (ADJP (JJ nutrient-)) (CC and) (ADJP (JJ calcium-regulated))) (NN _PROT1_) (NN _PROT1_) (NN isozyme)) (PP (IN in) (NP (NN mouse) (NNS islets))) (PP (TO to) (NP (NP (DT the) (JJ same) (NN extent)) (PP (IN as) (PP (IN in) (NP (NN rat) (NNS islets))))))))))) (VP (VBZ appears) (S (VP (TO to) (VP (VB account) (, ,) (PP (ADVP (IN at) (JJS least)) (IN in) (NP (NN part))) (, ,) (PP (IN for) (NP (DT these) (JJ different) (NN _PROT2_) (JJ secretory) (NNS responses))) (PP (IN under) (NP (DT these) (JJ unique) (NNS conditions))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Further)) (, ,) (NP (NP (DT the) (JJ _PROT1_) (NN activation)) (PP (IN of) (NP (NP (NN IK)) (PRN (-LRB- -LRB-) (NP (NN sl)) (-RRB- -RRB-))))) (VP (VBD was) (ADVP (RB effectively)) (VP (VBN antagonized) (PP (PP (IN by) (NP (NP (QP (QP (CD 5) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -8)) (-RRB- -RRB-))) (NN mol/l) (NN U-73122)) (CC or) (NP (NP (QP (QP (CD 5) (CC x) (CD 10)) (PRN (-LRB- -LRB-) (NP (CD -6)) (-RRB- -RRB-))) (NN mol/l) (NN 2-nitro-4-carboxyphenyl) (NN N)) (, ,) (NP (NP (NN N-diphenylcarbamate)) (PRN (-LRB- -LRB-) (NP (NP (NNS inhibitors)) (PP (IN of) (NP (DT the) (NN cell) (NN membrane) (NN phospholipase) (NN C)))) (-RRB- -RRB-)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN by) (NP (ADJP (RB intracellularly) (VBN applied)) (NN heparin)))))) (PRN (-LRB- -LRB-) (NP (NP (JJ selective) (NN inhibitor)) (PP (IN of) (NP (ADJP (NN _PROT2_) (-LRB- -LRB-) (NN IP3) (-RRB- -RRB-) (JJ -induced)) (NN Ca2+) (NN release) (NNS channels)))) (-RRB- -RRB-)))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS data)) (VP (VBN obtained))) (VP (VBP suggest) (S (LST (-LRB- -LRB-) (LS i) (-RRB- -RRB-)) (PP (IN that) (S (NP (JJ selective) (NN _PROT1_) (NNS receptors)) (VP (VBP are) (ADJP (JJ present) (PP (IN on) (NP (NP (DT the) (NNS membranes)) (PP (IN of) (NP (JJ guinea-pig) (JJ antral) (NN smooth) (NN muscle) (NNS cells))))))))) (, ,) (LST (-LRB- -LRB-) (LS ii) (-RRB- -RRB-)) (PP (IN that) (S (S (NP (DT the) (JJ oxytocin-related) (NN relaxation)) (VP (MD may) (VP (VB result) (PP (IN from) (NP (NP (DT the) (NN activation)) (PP (IN of) (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -sensitive)) (NN K+) (NN conductivity))))) (PP (IN via) (NP (NP (NN activation)) (PP (IN of) (NP (NP (JJ _PROT2_) (NN release)) (PP (IN of) (NP (NN Ca2+))) (PP (IN from) (NP (NP (DT the) (JJ submembrane) (JJ located) (NNS cisternae)) (PP (IN of) (NP (NP (DT the) (JJ sarcoplasmic) (NN reticulum)) (NN Ca2+) (NNS stores)))))))))))) (CC and) (S (LST (-LRB- -LRB-) (LS iii) (-RRB- -RRB-)) (PP (IN in) (NP (NN turn))) (, ,) (NP (DT this)) (VP (VBZ evokes) (NP (NP (DT a) (JJ non-inactivating) (NN component)) (PP (IN of) (NP (NN IK)))) (, ,) (S (VP (VBG hyperpolarizing) (NP (DT the) (NN cell) (NN membrane)))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ potent) (NNS antioxidants)) (, ,) (PP (JJ such) (IN as) (NP (NNS _PROT1_))) (, ,)) (VP (VP (VB protect) (NP (NP (NN MM-LDL)) (PP (IN from) (NP (NN lipoperoxidation))))) (CC and) (VP (VB preserve) (NP (PRP$ their) (NN ability) (S (VP (TO to) (ADVP (RB efficiently)) (VP (VB deliver) (NP (NN _PROT2_)) (PP (TO to) (NP (NNS cells)))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT2_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT2_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT1_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT1_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB elucidate) (NP (NP (DT the) (JJ pathophysiologic) (NN significance)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_)))) (PP (IN in) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NNS TZDs))) (PP (IN on) (NP (NP (NN glucose) (NN metabolism)) (CC and) (NP (NN energy) (NN expenditure)))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (PRP$ their) (JJ basal) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (DT the) (ADJP (ADJP (VBD WAT)) (, ,) (ADJP (JJ brown))) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (, ,) (CC and) (NP (NP (JJ skeletal) (NN muscle)) (PP (IN from) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT a) (NN rat) (NN model)) (PP (IN of) (NP (NP (NN NIDDM)) (CC and) (NP (NN obesity)))) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect)))) (, ,) (CC and) (NP (NP (VBN investigated) (NN expression)) (PP (IN of) (NP (NP (DT the) (NNS genes)) (VP (VBG encoding) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (JJ Wistar) (JJ fatty) (NNS rats))) (CC and) (PP (IN in) (NP (JJ Wistar) (JJ lean) (NNS rats)))) (PP (IN with) (NP (NP (JJ 2-week) (JJ oral) (NN administration)) (PP (IN of) (NP (NP (NP (CD 3) (NN mg) (NN x) (CD kg) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-) (NN x) (NN day) (-LRB- -LRB-) (CD -1) (-RRB- -RRB-)) (NN pioglitazone)) (, ,) (NP (DT a) (JJ TZD) (NN derivative)))))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NNS TZDs))) (PP (IN in) (NP (DT the) (VBD WAT) (NP (CC and) (NP (NN BAT)) (PP (IN in) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT an) (JJ obese) (NN model)) (PP (IN with) (NP (NN _PROT2_) (NN receptor) (NN defect))))))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN adipose) (NN _PROT_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN increased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NNS TZDs))))) (ADVP (FW in) (FW vitro)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NNS TZDs))) (PP (IN in) (NP (DT the) (VBD WAT) (NP (CC and) (NP (NN BAT)) (PP (IN in) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT an) (JJ obese) (NN model)) (PP (IN with) (NP (NN _PROT_) (NN receptor) (NN defect))))))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN adipose) (NN _PROT2_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN increased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NNS TZDs))))) (ADVP (FW in) (FW vitro)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (ADVP (RB clearly)) (VP (VBP demonstrate) (SBAR (SBAR (IN that) (S (NP (NN _PROT_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NNS TZDs))) (PP (IN in) (NP (DT the) (VBD WAT) (NP (CC and) (NP (NN BAT)) (PP (IN in) (NP (NP (JJ Wistar) (JJ fatty) (NNS rats)) (, ,) (NP (NP (DT an) (JJ obese) (NN model)) (PP (IN with) (NP (NN _PROT1_) (NN receptor) (NN defect))))))))))))) (, ,) (CC and) (SBAR (IN that) (S (NP (NN adipose) (NN _PROT2_) (NN gene) (NN expression)) (VP (VBZ is) (VP (VBN increased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (NNS TZDs))))) (ADVP (FW in) (FW vitro)))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (VBN Enhanced) (JJ phosphoinositide) (NN hydrolysis)) (PP (IN via) (NP (NP (NN overexpression)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (NN beta1) (NN or) (NN delta1)))))) (VP (VBZ inhibits) (NP (NP (JJ stimulus-induced) (NN _PROT2_) (NN release)) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (VBN enhanced) (JJ phosphoinositide) (NN hydrolysis))) (PP (IN on) (NP (NN _PROT1_) (NN secretion))))))) (, ,) (NP (NP (NP (JJ phosphoinositide-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLCbeta1)) (-RRB- -RRB-))) (CC or) (NP (NN _PROT_))) (VP (VBD was) (VP (VBN overexpressed) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells))) (PP (IN via) (NP (JJ adenoviral) (NNS vectors)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (VBN enhanced) (JJ phosphoinositide) (NN hydrolysis))) (PP (IN on) (NP (NN _PROT1_) (NN secretion))))))) (, ,) (NP (NP (NP (JJ phosphoinositide-specific) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLCbeta1)) (-RRB- -RRB-))) (CC or) (NP (NN _PROT2_))) (VP (VBD was) (VP (VBN overexpressed) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells))) (PP (IN via) (NP (JJ adenoviral) (NNS vectors)))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (VP (TO To) (VP (VB study) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (VBN enhanced) (JJ phosphoinositide) (NN hydrolysis))) (PP (IN on) (NP (NN _PROT_) (NN secretion))))))) (, ,) (NP (NP (NP (JJ phosphoinositide-specific) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLCbeta1)) (-RRB- -RRB-))) (CC or) (NP (NN _PROT2_))) (VP (VBD was) (VP (VBN overexpressed) (PP (IN in) (NP (NN insulinoma) (NN MIN6) (NNS cells))) (PP (IN via) (NP (JJ adenoviral) (NNS vectors)))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Constitutive) (NN expression)) (PP (IN of) (NP (NN PKABA1)))) (ADVP (RB drastically)) (VP (VBD suppressed) (NP (NP (NN expression)) (PP (IN of) (NP (NP (ADJP (ADJP (JJ low-)) (CC and) (ADJP (JJ high-pI))) (NP (NP (NN _PROT1_)) (CC and) (NP (NN protease))) (NNS genes)) (VP (VBN induced) (PP (IN by) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Long-term) (NNS changes)) (PP (IN in) (NP (NP (NN gastrin)) (, ,) (NP (NN cholecystokinin)) (CC and) (NP (NN _PROT1_)))) (PP (IN in) (NN response) (TO to) (NP (NN _PROT2_) (NN treatment)))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBD was) (VP (VBN designed) (S (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (JJ repeated) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBP influence) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (ADJP (RB vagally) (VBN controlled)) (NNS hormones)) (PP (JJ such) (IN as) (NP (NP (NN gastrin)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN somatostatin)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN of) (NP (NP (JJ endogenous) (NN _PROT_)) (CC and) (NP (NN glucose))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBD was) (VP (VBN designed) (S (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (JJ repeated) (NNS injections)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBP influence) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (ADJP (RB vagally) (VBN controlled)) (NNS hormones)) (PP (JJ such) (IN as) (NP (NP (NN gastrin)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN somatostatin)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN of) (NP (NP (JJ endogenous) (NN _PROT2_)) (CC and) (NP (NN glucose))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBD was) (VP (VBN designed) (S (VP (TO to) (VP (VB investigate) (SBAR (WHADVP (WRB how)) (S (NP (NP (JJ repeated) (NNS injections)) (PP (IN of) (NP (NN _PROT_)))) (VP (VBP influence) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (ADJP (RB vagally) (VBN controlled)) (NNS hormones)) (PP (JJ such) (IN as) (NP (NP (NN gastrin)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-))) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN somatostatin)))))) (, ,) (CONJP (RB as) (RB well) (IN as)) (PP (IN of) (NP (NP (JJ endogenous) (NN _PROT2_)) (CC and) (NP (NN glucose))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN CCK))) (NNS levels)) (VP (VBD were) (VP (VBN decreased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN treatment))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN measured) (PP (NP (QP (CD 3) (CC and) (CD 10)) (NNS days)) (IN after) (NP (NP (DT the) (JJ last) (NN injection)) (PRN (-LRB- -LRB-) (NP (NN ANOVA)) (: ;) (NP (NN _PROT_) (NN p) (NN <) (CD 0.01)) (, ,) (NP (NN CCK) (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (CC both) (NP (NN _PROT1_)) (CC and) (NP (NN CCK))) (NNS levels)) (VP (VBD were) (VP (VBN decreased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (DT the) (NN _PROT_) (NN treatment))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN measured) (PP (NP (QP (CD 3) (CC and) (CD 10)) (NNS days)) (IN after) (NP (NP (DT the) (JJ last) (NN injection)) (PRN (-LRB- -LRB-) (NP (NN ANOVA)) (: ;) (NP (NN _PROT2_) (NN p) (NN <) (CD 0.01)) (, ,) (NP (NN CCK) (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (CC both) (NP (NN _PROT_)) (CC and) (NP (NN CCK))) (NNS levels)) (VP (VBD were) (VP (VBN decreased) (PP (IN in) (NP (NP (NN response)) (PP (TO to) (NP (DT the) (NN _PROT1_) (NN treatment))))) (SBAR (WHADVP (WRB when)) (S (VP (VBN measured) (PP (NP (QP (CD 3) (CC and) (CD 10)) (NNS days)) (IN after) (NP (NP (DT the) (JJ last) (NN injection)) (PRN (-LRB- -LRB-) (NP (NN ANOVA)) (: ;) (NP (NN _PROT2_) (NN p) (NN <) (CD 0.01)) (, ,) (NP (NN CCK) (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NP (DT the) (JJ alpha2-adrenoreceptor) (NN agonist) (NN clonidine)) (PRN (-LRB- -LRB-) (NP (CD 2.5) (NN microgram/kg) (NN intracerebroventricularly)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN administered) (PP (NP (CD 3) (NNS days)) (IN after) (NP (DT the) (JJ 5-day) (NN treatment) (NN period))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (NN saline)))))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN CCK))))) (VP (VBD increased) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN in) (NP (DT the) (JJ _PROT_) (NNS rats)))) (, ,) (SBAR (WHADVP (WRB when)) (S (VP (VBN compared) (PP (TO to) (NP (NP (JJ saline-treated) (NNS controls)) (VP (VBG receiving) (NP (NP (NN clonidine)) (ADVP (RB only))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NP (DT the) (JJ alpha2-adrenoreceptor) (NN agonist) (NN clonidine)) (PRN (-LRB- -LRB-) (NP (CD 2.5) (NN microgram/kg) (NN intracerebroventricularly)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN administered) (PP (NP (CD 3) (NNS days)) (IN after) (NP (DT the) (JJ 5-day) (NN treatment) (NN period))) (PP (IN with) (NP (NP (NN _PROT1_)) (CC or) (NP (NN saline)))))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN CCK))))) (VP (VBD increased) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NNS rats)))) (, ,) (SBAR (WHADVP (WRB when)) (S (VP (VBN compared) (PP (TO to) (NP (NP (JJ saline-treated) (NNS controls)) (VP (VBG receiving) (NP (NP (NN clonidine)) (ADVP (RB only))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (NP (DT the) (JJ alpha2-adrenoreceptor) (NN agonist) (NN clonidine)) (PRN (-LRB- -LRB-) (NP (CD 2.5) (NN microgram/kg) (NN intracerebroventricularly)) (-RRB- -RRB-))) (VP (VBD was) (VP (VBN administered) (PP (NP (CD 3) (NNS days)) (IN after) (NP (DT the) (JJ 5-day) (NN treatment) (NN period))) (PP (IN with) (NP (NP (NN _PROT_)) (CC or) (NP (NN saline)))))))) (, ,) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN CCK))))) (VP (VBD increased) (ADVP (RB significantly)) (PRN (-LRB- -LRB-) (NP (NN p) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN in) (NP (DT the) (JJ _PROT2_) (NNS rats)))) (, ,) (SBAR (WHADVP (WRB when)) (S (VP (VBN compared) (PP (TO to) (NP (NP (JJ saline-treated) (NNS controls)) (VP (VBG receiving) (NP (NP (NN clonidine)) (ADVP (RB only))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN conclusion))) (, ,) (NP (DT these) (NNS results)) (VP (VBP show) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (NP (JJ long-lasting) (NNS changes)) (PP (IN in) (NP (NP (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN gastrin)) (, ,) (NP (NN CCK)) (CC and) (NP (NN _PROT2_))))))) (, ,) (PP (IN without) (S (VP (VBG affecting) (NP (NP (NP (NN somatostatin)) (CC or) (NP (NN glucose))) (NNS levels))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Plasma) (NN _PROT1_)) (, ,) (CC and) (NP (NP (DT some) (ADJP (RB functionally) (JJ related)) (NNS peptides)) (PRN (-LRB- -LRB-) (NP (NP (NN CCK)) (, ,) (NP (NN gastrin)) (, ,) (NP (NN somatostatin)) (CC and) (NP (NN _PROT2_))) (-RRB- -RRB-))) (, ,)) (VP (VBD were) (VP (VBN measured) (PP (IN by) (NP (JJ standard) (NN radioimmunoassay) (NNS techniques))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ _PROT1_) (NNS elements)) (VP (VBN conserved) (PP (IN in) (NP (JJ cereal) (NN _PROT2_) (NNS genes))))) (VP (VBP are) (RB not) (VP (VBN included) (PP (IN in) (NP (NP (DT the) (JJ 5'-upstream) (NN region)) (PP (IN of) (NP (NP (NN Rep1)) (CC or) (NP (NN RepA)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (, ,) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN mitogen) (JJ activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NN kinase)) (ADVP (RB alone))))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB promote) (NP (NN _PROT1_) (NN secretion))))))))))) (, ,) (IN whereas) (S (NP (NP (NN inhibition)) (PP (IN of) (NP (NN MAP) (NN kinase)))) (VP (MD will) (VP (VB reduce) (NP (NN _PROT2_) (NN secretion)) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (NP (NN _PROT_) (NN _PROT_)) (CC or) (NP (NN phosphatidylinositol) (NN 3-kinase))) (VP (VBP are) (ADVP (RB additionally)) (VP (VBN inhibited)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (, ,) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN mitogen) (JJ activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NN kinase)) (ADVP (RB alone))))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB promote) (NP (NN _PROT1_) (NN secretion))))))))))) (, ,) (IN whereas) (S (NP (NP (NN inhibition)) (PP (IN of) (NP (NN MAP) (NN kinase)))) (VP (MD will) (VP (VB reduce) (NP (NN _PROT_) (NN secretion)) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN phosphatidylinositol) (NN 3-kinase))) (VP (VBP are) (ADVP (RB additionally)) (VP (VBN inhibited)))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP$ Our) (NNS data)) (VP (VBP demonstrate) (, ,) (SBAR (IN that) (S (NP (NP (NN activation)) (PP (IN of) (NP (NP (NN mitogen) (JJ activated) (NN protein) (-LRB- -LRB-) (NN MAP) (-RRB- -RRB-) (NN kinase)) (ADVP (RB alone))))) (VP (VBZ is) (ADJP (JJ sufficient) (S (VP (TO to) (VP (VB promote) (NP (NN _PROT_) (NN secretion))))))))))) (, ,) (IN whereas) (S (NP (NP (NN inhibition)) (PP (IN of) (NP (NN MAP) (NN kinase)))) (VP (MD will) (VP (VB reduce) (NP (NN _PROT1_) (NN secretion)) (SBAR (WHADVP (RB only) (WRB when)) (S (NP (NP (NN _PROT2_) (NN _PROT2_)) (CC or) (NP (NN phosphatidylinositol) (NN 3-kinase))) (VP (VBP are) (ADVP (RB additionally)) (VP (VBN inhibited)))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Tolbutamide)) (CC and) (NP (NN diazoxide))) (VP (VBP modulate) (NP (NP (NP (NP (NP (NN _PROT1_) (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NN signaling)) (CC and) (NP (NN _PROT2_) (NN secretion))) (PP (IN in) (NP (NNS beta-cells))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (SBAR (IN whether) (S (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide)) (, ,) (SBAR (WHNP (WDT which)) (S (ADJP (ADJP (JJ close)) (CC or) (ADJP (JJ open)) (NP (NP (NP (NP (JJ ATP-sensitive) (NN K)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS channels)) (PRN (-LRB- -LRB-) (NP (NN K) (-LRB- -LRB-) (NN ATP) (-RRB- -RRB-) (NNS channels)) (-RRB- -RRB-))) (, ,) (ADVP (RB respectively))))) (, ,)) (VP (VBP interact) (PP (PP (IN with) (NP (NP (NP (NP (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NNS signals)) (PP (IN in) (NP (NN HIT-T15) (CC and) (NN mouse) (NNS beta-cells))))) (CC and) (PP (IN with) (NP (NP (JJ _PROT2_) (NN _PROT_) (NN secretion)) (PP (IN from) (NP (NN HIT-T15) (NNS cells)))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (SBAR (IN whether) (S (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide)) (, ,) (SBAR (WHNP (WDT which)) (S (ADJP (ADJP (JJ close)) (CC or) (ADJP (JJ open)) (NP (NP (NP (NP (JJ ATP-sensitive) (NN K)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS channels)) (PRN (-LRB- -LRB-) (NP (NN K) (-LRB- -LRB-) (NN ATP) (-RRB- -RRB-) (NNS channels)) (-RRB- -RRB-))) (, ,) (ADVP (RB respectively))))) (, ,)) (VP (VBP interact) (PP (PP (IN with) (NP (NP (NP (NP (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NNS signals)) (PP (IN in) (NP (NN HIT-T15) (CC and) (NN mouse) (NNS beta-cells))))) (CC and) (PP (IN with) (NP (NP (JJ _PROT_) (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NN HIT-T15) (NNS cells)))))))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (SBAR (IN whether) (S (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide)) (, ,) (SBAR (WHNP (WDT which)) (S (ADJP (ADJP (JJ close)) (CC or) (ADJP (JJ open)) (NP (NP (NP (NP (JJ ATP-sensitive) (NN K)) (-LRB- -LRB-) (CC +) (-RRB- -RRB-)) (NNS channels)) (PRN (-LRB- -LRB-) (NP (NN K) (-LRB- -LRB-) (NN ATP) (-RRB- -RRB-) (NNS channels)) (-RRB- -RRB-))) (, ,) (ADVP (RB respectively))))) (, ,)) (VP (VBP interact) (PP (PP (IN with) (NP (NP (NP (NP (JJ _PROT_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NNS signals)) (PP (IN in) (NP (NN HIT-T15) (CC and) (NN mouse) (NNS beta-cells))))) (CC and) (PP (IN with) (NP (NP (JJ _PROT1_) (NN _PROT2_) (NN secretion)) (PP (IN from) (NP (NN HIT-T15) (NNS cells)))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (NP (NP (NN tolbutamide)) (CC and) (NP (NN diazoxide))) (VP (VBP regulate) (NP (NP (CC both) (NP (NP (NP (JJ _PROT1_) (NN Ca)) (PRN (-LRB- -LRB-) (NP (NN 2+)) (-RRB- -RRB-))) (NN signaling)) (CC and) (NP (NN _PROT2_) (NN secretion))) (PP (IN from) (NP (JJ pancreatic) (NNS beta-cells)))) (PP (IN by) (S (VP (VBG modulating) (NP (NP (NP (NN K)) (PRN (-LRB- -LRB-) (NP (NN ATP)) (-RRB- -RRB-))) (NNS channels))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG determining) (NP (JJ voltage-sensitive) (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (NN influx))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBD examined) (PP (IN for) (NP (DT the) (JJ first) (NN time))) (PP (IN in) (NP (NP (NP (JJ young) (NNS men) (NNS effects)) (PP (IN of) (NP (NP (JJ intravenous) (NNS injections)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (NP (QP (CD 4x50) (CC or) (CD 100)) (NN microg)) (, ,) (S (NP (NN n)) (VP (JJ =) (NP (CD 9) (CC and) (CD 11)) (, ,) (ADVP (RB respectively)) (, ,) (PP (IN at) (NP (NP (CD 22.00)) (, ,) (NP (CD 23.00)) (, ,) (NP (CD 24.00)) (CC and) (NP (CD 01.00))))))) (VP (VBN compared) (PP (TO to) (NP (NN saline))))) (-RRB- -RRB-)))))) (PP (IN on) (NP (NP (DT the) (JJ sleep) (NN electroencephalogram)) (PRN (-LRB- -LRB-) (NP (NN EEG)) (: ;) (S (VP (VBN recorded) (PP (IN from) (NP (CD 23.00) (TO to) (CD 07.00))))) (-RRB- -RRB-))))) (CC and) (NP (NP (JJ nocturnal) (NN secretion)) (PP (IN of) (NP (NP (NP (JJ adrenocorticotrophic) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN ACTH)) (-RRB- -RRB-))) (, ,) (NP (NN cortisol)) (, ,) (NP (NP (NN growth) (NN hormone)) (PRN (-LRB- -LRB-) (NP (NN GH)) (-RRB- -RRB-))) (, ,) (NP (NN prolactin)) (CC and) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN T3)) (VP (MD may) (VP (VB increase) (NP (NP (NN _PROT1_) (NN family) (NN expression)) (ADJP (JJ independent) (PP (IN of) (NP (NN _PROT2_) (NN action)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NNS effects)) (PP (IN on) (NP (NP (JJ pulsatile) (NN gonadotropin) (VBG releasing) (NN hormone) (NN secretion)) (PP (IN from) (NP (DT the) (JJ adult) (NN rat) (NN hypothalamus)))))) (CC and) (NP (NP (NN interaction)) (PP (IN with) (NP (NP (NP (NN cocaine)) (CC and) (NP (NN amphetamine))) (NP (NP (VBN regulated) (NN transcript) (NN peptide)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))) (VP (VBP [In) (NP (NN Process) (NP (NNP Citation)))) (-RRB- -RSB-))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (MD may) (VP (VB act) (PP (IN as) (NP (NP (DT a) (JJ negative) (NN feedback) (NN signal)) (PP (TO to) (NP (NP (DT the) (JJ hypothalamic) (NN control)) (PP (IN of) (NP (NN appetite))))))) (PP (IN through) (NP (NP (NP (NN suppression)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (NN secretion)))) (CC and) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN cocaine)) (CC and) (NP (NP (NN amphetamine) (JJ regulated) (NN transcript)) (PRN (-LRB- -LRB-) (NP (NN CART)) (-RRB- -RRB-))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD aimed) (PP (IN at) (S (VP (VBG studying) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN CART)) (CC and) (NP (NN _PROT2_)))) (PP (IN on) (NP (NP (DT the) (JJ hypothalamic) (NN control)) (PP (IN of) (NP (DT the) (JJ pituitary-gonadal) (NN system))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (DT The) (NN increase)) (PP (IN in) (NP (NN GnRH) (NN pulse) (NN amplitude))) (VP (VBN caused) (PP (IN by) (NP (NN _PROT1_))))) (VP (VBD was) (ADVP (RB totally)) (VP (VBN prevented) (PP (IN by) (NP (NP (NN coincubation)) (PP (IN with) (NP (NP (DT an) (JJ anti-CART) (NN antiserum)) (SBAR (IN whereas) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN affected) (PP (IN by) (NP (NP (NN coincubation)) (PP (IN with) (NP (NP (DT the) (NN _PROT2_) (JJ Y5-receptor) (NN antagonist)) (PRN (-LRB- -LRB-) (NP (CD 10) (-LRB- -LRB-) (CD -7) (-RRB- -RRB-) (NN M)) (-RRB- -RRB-))))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (VP (VBP show) (NP (NP (JJ separate) (JJ permissive) (NNS effects)) (PP (IN on) (NP (NP (NN GnRH) (NN secretion)) (PP (IN in) (NP (DT the) (JJ adult) (NN rat) (NN hypothalamus)))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN induction)) (PP (IN of) (NP (NN _PROT1_))) (VP (VBN triggered) (PP (IN by) (NP (JJ _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (JJ barley) (NNS embryos))))) (VP (VBZ is) (VP (VBN repressed) (PP (IN by) (NP (NNS sugars))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN glucose)) (VP (VBZ represses) (NP (NN _PROT1_) (NN signalling)) (ADVP (RB late)) (PP (IN along) (NP (DT this) (NN hormone) (NN transduction) (NN pathway))) (, ,) (ADVP (RB downstream) (PP (IN of) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (DT the) (JJ _PROT2_) (JJ transcriptional) (NN activator)) (PRN (-LRB- -LRB-) (NP (NN GAMYB)) (-RRB- -RRB-))))))) (VP (VBN needed) (PP (IN for) (NP (NN _PROT_) (NN induction)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN glucose)) (VP (VBZ represses) (NP (NN _PROT1_) (NN signalling)) (ADVP (RB late)) (PP (IN along) (NP (DT this) (NN hormone) (NN transduction) (NN pathway))) (, ,) (ADVP (RB downstream) (PP (IN of) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (DT the) (JJ _PROT_) (JJ transcriptional) (NN activator)) (PRN (-LRB- -LRB-) (NP (NN GAMYB)) (-RRB- -RRB-))))))) (VP (VBN needed) (PP (IN for) (NP (NN _PROT2_) (NN induction)))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP$ Our) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN glucose)) (VP (VBZ represses) (NP (NN _PROT_) (NN signalling)) (ADVP (RB late)) (PP (IN along) (NP (DT this) (NN hormone) (NN transduction) (NN pathway))) (, ,) (ADVP (RB downstream) (PP (IN of) (NP (NP (NN transcription)) (PP (IN of) (NP (NP (DT the) (JJ _PROT1_) (JJ transcriptional) (NN activator)) (PRN (-LRB- -LRB-) (NP (NN GAMYB)) (-RRB- -RRB-))))))) (VP (VBN needed) (PP (IN for) (NP (NN _PROT2_) (NN induction)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN _PROT2_) (NN production)) (PP (IN in) (NP (JJ dose-dependent) (NN fashion))) (PP (IN as) (NP (NN well)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN binding))) (PP (IN in) (NP (JJ human) (NN myometrium)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Carbachol)) (CC and) (NP (NN _PROT1_))) (VP (VBP stimulate) (NP (NP (DT the) (NN generation)) (PP (IN of) (NP (JJ _PROT2_) (NNS _PROT2_))) (PP (IN in) (NP (NP (DT the) (NN guinea) (NN pig)) (NN myometrium))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (DT the) (NP (NN guinea) (NN pig)) (NN myometrium)) (VP (VBN prelabelled) (PP (IN with) (NP (ADJP (NN myo-[2-3H) (-RRB- -RSB-) (JJ inositol))))))) (, ,) (NP (NP (NN carbachol)) (CC and) (NP (NN _PROT1_))) (VP (VBD enhanced) (NP (NP (DT a) (ADJP (ADJP (JJ concentration-dependent)) (CC and) (ADJP (JJ rapid))) (NN release)) (PP (IN of) (NP (NN _PROT2_))) (SBAR (WHNP (WDT which)) (S (VP (VBD preceded) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN IP2)) (CC and) (NP (NN IP1)))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP They)) (VP (VBP are) (VP (VBN needed) (PP (IN for) (NP (NP (DT the) (NN catabolism)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN bile) (NNS acids)) (, ,) (CC and) (NP (NN steroid) (NNS hormones))))))))) (: ;) (S (NP (PRP they)) (VP (VB hydrolyze) (NP (NP (DT a) (NN number)) (PP (IN of) (NP (NN _PROT2_) (NNS glycosides))) (PP (TO to) (NP (NNS anticarcinogens)))))) (: ;) (CC and) (S (NP (PRP they)) (VP (VB detoxify) (NP (JJ certain) (NNS carcinogens)))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (NP (NN treatment)) (PP (IN of) (NP (NP (VBN isolated) (NN rat) (NNS diaphragms)) (CC and) (NP (NNS adipocytes)))) (PP (IN with) (NP (NN PIG-P))) (PP (CONJP (RB as) (RB well) (IN as)) (PP (IN with) (NP (NP (JJ other) (NNS agents)) (VP (VBG exerting) (NP (ADJP (RB partially) (JJ _PROT1_)) (NN activity))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (JJ PI-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NN sulfonylurea) (NN glimepiride)))))) (, ,))) (VP (VBD triggered) (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (DT the) (JJ caveolar) (NN marker) (NN protein) (NN caveolin))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD was) (ADVP (RB apparently)) (VP (VBN correlated) (PP (IN with) (NP (NP (NN stimulation)) (PP (IN of) (NP (NN lipogenesis))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Strikingly)) (, ,) (PP (IN in) (NP (NP (NNS adipocytes)) (VP (VBN subjected) (PP (TO to) (NP (NP (JJ combined) (NN trypsin/salt) (NN treatment)) (, ,) (NP (NN PIG-P)) (, ,) (NP (JJ PI-specific) (NN _PROT1_)) (, ,) (CC and) (NP (NN glimepiride))))))) (VP (VBD failed) (S (ADVP (RB completely)) (VP (TO to) (VP (VB provoke) (NP (JJ _PROT2_) (NNS effects)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Neural) (NN site)) (PP (IN of) (NP (NN _PROT1_) (NN influence))) (PP (IN on) (NP (NP (NP (NN neuropeptide) (NN Y)) (NN signaling) (NNS pathways)) (VP (VBG altering) (NP (NP (NN feeding)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN NPY)) (PP (IN in) (NP (DT the) (NNS PVN)))) (VP (VP (VBZ increases) (NP (NN feeding))) (CC and) (VP (VBZ decreases) (NP (NP (NP (NN _PROT1_) (NN _PROT1_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-)) (NN activity)) (PP (IN in) (NP (NN brown) (NN fat))))))) (, ,) (IN whereas) (S (NP (NN _PROT2_)) (VP (VBZ decreases) (NP (NP (NN NPY) (NN biosynthesis)) (PP (IN in) (NP (DT the) (NN Arc))) (, ,) (SBAR (WHNP (WDT which)) (S (ADVP (RB presumably)) (VP (VBZ decreases) (NP (NN PVN) (NN NPY)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Next)) (, ,) (NP (PRP we)) (VP (VBD determined) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VP (VBZ decreases) (NP (NN NPY))) (CC and) (VP (VBZ increases) (NP (NN _PROT2_) (NN gene) (NN expression))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (JJ immunocytochemical) (NNS studies)) (VP (VBD showed) (NP (NP (DT the) (NN _PROT1_) (JJ _PROT1_) (JJ neuronal) (NN MAC) (NN expression)) (PP (IN on) (NP (DT the) (NN SH-SY5Y) (NNS cells)))) (SBAR (IN after) (S (NP (NN CD59)) (VP (VBD was) (VP (VP (VBN removed) (PP (IN by) (NP (NN _PROT2_)))) (CC or) (VP (VBN blocked) (PP (IN by) (NP (CD anti-CD59) (NN antibody))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT_)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT_)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT_)))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (CC and) (NP (NN _PROT_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN _PROT1_))) (NN gene) (NN expression)) (: :) (NP (NP (NP (NN modulation)) (PP (IN by) (NP (NN food) (NN restriction)))) (CC and) (NP (NN _PROT2_)))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN food) (NN restriction)) (CC and) (NP (NN _PROT1_) (NN administration))) (PP (IN on) (NP (NP (JJ several) (NNS transcripts)) (VP (VBN involved) (PP (IN in) (NP (NN energy) (NN homeostasis)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (NP (NP (NP (NN _PROT2_)) (, ,) (NP (VBG _PROT_) (NNS _PROT_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-) (CD 1) (, ,) (CD 2) (CC and) (CD 3)) (, ,) (NP (NP (NN lipoprotein) (NN lipase)) (PRN (-LRB- -LRB-) (NP (NN LPL)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ beta3-adrenergic) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN beta3AR)) (-RRB- -RRB-))) (CC and) (NP (JJ hormone-sensitive) (NN lipase))) (PRN (-LRB- -LRB-) (NP (NN HSL)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ epididymal) (-LRB- -LRB-) (NN EWAT) (-RRB- -RRB-) (CC and) (JJ perirenal) (-LRB- -LRB-) (NN PWAT) (-RRB- -RRB-) (JJ white) (NN adipose) (NN tissue)))) (PP (IN in) (NP (NP (CD three) (NNS groups)) (PP (IN of) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN food) (NN restriction)) (CC and) (NP (NN _PROT1_) (NN administration))) (PP (IN on) (NP (NP (JJ several) (NNS transcripts)) (VP (VBN involved) (PP (IN in) (NP (NN energy) (NN homeostasis)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (NP (NP (NP (NN _PROT_)) (, ,) (NP (VBG _PROT2_) (NNS _PROT2_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-) (CD 1) (, ,) (CD 2) (CC and) (CD 3)) (, ,) (NP (NP (NN lipoprotein) (NN lipase)) (PRN (-LRB- -LRB-) (NP (NN LPL)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ beta3-adrenergic) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN beta3AR)) (-RRB- -RRB-))) (CC and) (NP (JJ hormone-sensitive) (NN lipase))) (PRN (-LRB- -LRB-) (NP (NN HSL)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ epididymal) (-LRB- -LRB-) (NN EWAT) (-RRB- -RRB-) (CC and) (JJ perirenal) (-LRB- -LRB-) (NN PWAT) (-RRB- -RRB-) (JJ white) (NN adipose) (NN tissue)))) (PP (IN in) (NP (NP (CD three) (NNS groups)) (PP (IN of) (NP (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB determine) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN food) (NN restriction)) (CC and) (NP (NN _PROT_) (NN administration))) (PP (IN on) (NP (NP (JJ several) (NNS transcripts)) (VP (VBN involved) (PP (IN in) (NP (NN energy) (NN homeostasis)))))))))))) (, ,) (S (NP (PRP we)) (VP (VBD examined) (NP (NP (NP (NP (NP (NN _PROT1_)) (, ,) (NP (VBG _PROT2_) (NNS _PROT2_) (-LRB- -LRB-) (NN UCP) (-RRB- -RRB-) (CD 1) (, ,) (CD 2) (CC and) (CD 3)) (, ,) (NP (NP (NN lipoprotein) (NN lipase)) (PRN (-LRB- -LRB-) (NP (NN LPL)) (-RRB- -RRB-))) (, ,) (NP (NP (JJ beta3-adrenergic) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN beta3AR)) (-RRB- -RRB-))) (CC and) (NP (JJ hormone-sensitive) (NN lipase))) (PRN (-LRB- -LRB-) (NP (NN HSL)) (-RRB- -RRB-))) (NN mRNA) (NNS levels)) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ epididymal) (-LRB- -LRB-) (NN EWAT) (-RRB- -RRB-) (CC and) (JJ perirenal) (-LRB- -LRB-) (NN PWAT) (-RRB- -RRB-) (JJ white) (NN adipose) (NN tissue)))) (PP (IN in) (NP (NP (CD three) (NNS groups)) (PP (IN of) (NP (NNS rats)))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT2_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT2_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT1_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT2_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT1_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (VP (VP (VBD increased) (NP (NP (NP (NN LPL) (NN mRNA)) (PP (IN by) (NP (CD 80) (NN %)))) (, ,) (NP (NN _PROT_) (NN mRNA) (JJ twofold)) (, ,) (CC and) (NP (NN _PROT1_) (NN mRNA) (NNS levels))) (PP (IN by) (NP (NP (CD 62) (NN %)) (PP (IN in) (NP (NN BAT)))))) (, ,) (CC and) (VP (VBD increased) (NP (NN _PROT2_) (NN mRNA) (NNS levels)) (ADVP (RB twofold)) (PP (IN in) (NP (NN EWAT))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NN study)) (VP (VBZ indicates) (SBAR (IN that) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NP (NP (DT the) (NN gene) (NN expression)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN EWAT)))) (CC and) (NP (NP (DT that)) (PP (IN of) (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (CC and) (NP (NN LPL)))) (PP (IN in) (NP (NN BAT))))) (, ,) (SBAR (IN whereas) (S (NP (NP (VBN reduced) (NN food) (NN consumption)) (CONJP (CC but) (RB not)) (NP (NN leptin)) (, ,)) (VP (VBZ decreases) (NP (NN LPL) (NN expression)) (PP (IN in) (S (VP (VBD WAT))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN OT)) (-RRB- -RRB-))) (VP (VBZ is) (ADVP (RBR more)) (VP (VBN expressed) (PP (IN in) (DT the) (NN TEC/TNC) (IN than) (NP (NP (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN VP)) (-RRB- -RRB-))))))) (: ;) (S (NP (NP (NP (JJ insulin-like) (NN growth) (NN factor) (CD 2)) (PRN (-LRB- -LRB-) (NP (NN IGF-2)) (-RRB- -RRB-))) (JJ thymic) (NN expression)) (VP (VP (VBZ predominates) (PP (IN over) (NP (NN IGF-1)))) (, ,) (CC and) (VP (ADJP (RB much) (JJR more)) (PP (IN over) (NP (LST (-LRB- _PROT2_) (LS _PROT2_) (-RRB- _PROT2_)) (NN _PROT2_)))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (S (S (NP (NN _PROT1_)) (VP (VBD was) (VP (VBN proposed) (S (VP (TO to) (VP (VB be) (NP (NP (DT the) (NN self) (NN antigen)) (PP (IN of) (NP (DT the) (JJ neurohypophysial) (NN family)))))))))) (, ,) (CC and) (S (NP (NN IGF-2)) (NP (NP (DT the) (NN self) (NN antigen) (NN precursor)) (PP (IN of) (NP (DT the) (NN _PROT2_) (NN family)))))))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBD observed) (SBAR (IN that) (S (NP (NP (JJ primary) (JJ microglial) (NNS cultures)) (CC and) (NP (DT the) (NN THP-1) (JJ monocytic) (NN cell) (NN line))) (VP (VBP are) (VP (VBN stimulated) (PP (IN by) (NP (JJ fibrillar) (NN beta-amyloid) (CC and) (NN _PROT1_) (NNS peptides))) (S (VP (TO to) (VP (VB activate) (NP (JJ identical) (NN _PROT2_) (JJ _PROT2_) (JJ inflammatory) (NN signal) (NN transduction) (NNS cascades)))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (JJ Molecular) (NN characterization)) (PP (IN of) (NP (NP (NN catalytic-subunit) (NN cDNA) (NNS sequences)) (VP (VBG encoding) (NP (NN protein) (NNS phosphatases) (NP (NP (CD 1)) (CC and) (NP (NN 2A)))))))) (CC and) (NP (NP (NN study)) (PP (IN of) (NP (NP (PRP$ their) (NNS roles)) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN _PROT2_) (NN expression)) (PP (IN in) (NP (NN rice))))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (VP (VB understand) (NP (NP (DT the) (JJ molecular) (NN mechanism)) (PP (IN of) (NP (JJ _PROT1_) (NN gene) (NN regulation))))))) (, ,) (S (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (CD three) (NN phosphatase) (NNS inhibitors))) (PP (IN on) (NP (NP (NP (DT the) (NN germination)) (PP (IN of) (NP (NN rice) (NNS seeds)))) (CC and) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NP (DT a) (NN target) (NN gene)) (, ,) (NP (DT the) (NN _PROT2_) (NN gene)) (, ,) (NP (NN Osamy-c)) (, ,))))))) (VP (VBD were) (VP (VBN measured)))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (ADVP (RB further)) (VP (VB understand) (NP (NP (DT the) (JJ possible) (NN role)) (PP (IN of) (NP (NN protein) (NNS phosphatases) (NP (NP (CD 1)) (CC and) (NP (NN 2A))))) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))) (, ,) (S (NP (PRP we)) (VP (VBD isolated) (NP (NP (NN cDNA) (NNS clones)) (VP (VBG encoding) (NP (NP (NN protein) (NN phosphatase) (CD 1)) (CC and) (NP (NN protein) (NN phosphatase) (NN 2A))))) (PP (IN from) (NP (DT a) (NN rice) (NN aleurone) (NN cDNA) (NN library))))))) |ET|
+1 |BT| (S1 (S (S (VP (VBN Taken) (ADVP (RB together)))) (, ,) (S (NP (PRP$ our) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN protein) (NNS phosphatases) (NP (NP (NN PP1)) (CC or) (NP (NN PP2A)))) (VP (VBP are) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (JJ _PROT1_) (NN expression)) (PP (IN of) (NP (DT the) (NN rice) (NN _PROT2_) (NN gene)))))) (, ,) (SBAR (IN though) (S (NP (NP (DT the) (NN PP1) (JJ or/and) (NN PP2A) (JJ enzymatic) (NNS activities)) (CONJP (RB as) (RB well) (IN as)) (NP (NN mRNA) (NNS levels))) (VP (VBP do) (RB not) (VP (VB increase) (PP (IN upon) (NP (NN GA3) (NN treatment)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (JJ fetal) (NN guinea) (NN pig) (NN brain) (NNS cultures)))) (ADVP (RB substantially)) (VP (VP (VBD reduced) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))) (PP (IN in) (NP (DT the) (NN medium)))) (CC but) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN sAPPalpha))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (JJ fetal) (NN guinea) (NN pig) (NN brain) (NNS cultures)))) (ADVP (RB substantially)) (VP (VP (VBD reduced) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))) (PP (IN in) (NP (DT the) (NN medium)))) (CC but) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN sAPPalpha))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN _PROT_) (NN treatment)) (PP (IN of) (NP (JJ fetal) (NN guinea) (NN pig) (NN brain) (NNS cultures)))) (ADVP (RB substantially)) (VP (VP (VBD reduced) (NP (NP (DT the) (NN amount)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))) (PP (IN in) (NP (DT the) (NN medium)))) (CC but) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NN sAPPalpha))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))))))) (, ,) (S (S (NP (NP (NN _PROT2_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT_))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))))))) (, ,) (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT1_))))))) (, ,) (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT_))))))) (, ,) (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT_))))))) (, ,) (S (S (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (NP (DT this) (JJ parental) (NN line)) (VP (VBD was) (VP (VBN treated) (PP (IN with) (NP (NN _PROT_))))))) (, ,) (S (S (NP (NP (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN sAPPbeta))) (VP (VBD decreased) (PP (TO to) (NP (NP (NNS levels)) (ADJP (JJ similar) (PP (TO to) (NP (NP (DT those)) (VP (VBN observed) (PP (IN in) (NP (DT the) (JJ mutant) (NN line))))))))))) (, ,) (CC and) (S (NP (DT the) (JJ mutant) (NN line)) (VP (VBD was) (ADJP (JJ resistant) (PP (TO to) (NP (NP (DT these) (NNS effects)) (PP (IN of) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN tyrosine) (NN phosphorylation)) (PP (IN by) (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN rat) (JJ smooth) (NN muscle) (NN cell) (NN line))))))) (, ,) (NP (NN A-10)))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PKC)) (-RRB- -RRB-))) (NNS inhibitors)) (: :) (NP (NP (NN staurosporine)) (, ,) (NP (NN H7)) (CC and) (NP (NN GF109203X)))) (VP (VBP are) (ADJP (JJ able) (S (VP (TO to) (VP (VB block) (NP (DT the) (JJ _PROT2_) (NN phosphorylation))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ is) (ADVP (RB upstream) (PP (IN of) (NP (DT the) (NN phosphorylation)))) (, ,) (NP (NP (DT a) (NN motion)) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN supported) (PP (IN by) (NP (DT the) (NN fact) (SBAR (IN that) (S (NP (DT the) (JJ _PROT2_) (NN phosphorylation)) (VP (VBD was) (VP (VBN downregulated) (PP (IN by) (NP (NN phorbol) (NNS esters)))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Aggregated) (NN beta) (NN _PROT1_) (NN peptide) (NN 1-40)) (VP (VBZ decreases) (NP (NP (NN Ca2+-)) (CC and) (NP (JJ cholinergic) (JJ receptor-mediated) (NN phosphoinositide) (NN degradation))) (PP (IN by) (NP (NP (NN alteration)) (PP (IN of) (NP (NP (NN membrane)) (CC and) (NP (JJ cytosolic) (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NN brain) (NN cortex)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NNS effects)) (PP (IN of) (NP (NP (JJ full-length) (NN _PROT1_) (NN beta) (NN protein)) (, ,) (NP (NP (NP (NN A)) (PRN (-LRB- -LRB-) (NP (NN beta)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN 1-40)) (-RRB- -RRB-))) (, ,))) (PP (IN on) (NP (NP (JJ phosphoinositide-specific) (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))) (VP (VBD were) (VP (VBN investigated) (PP (IN in) (NP (NP (NP (JJ synaptic) (NN plasma) (NNS membranes)) (PRN (-LRB- -LRB-) (NP (NN SPM)) (-RRB- -RRB-))) (CC and) (NP (NP (NN cytosol)) (VP (VBN prepared) (PP (IN from) (NP (NP (DT the) (JJ cerebral) (NN cortex)) (PP (IN of) (NP (JJ adult) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (JJ Aggregated) (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (ADVP (RB also)) (VP (VBD decreased) (ADVP (RB significantly)) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN diacylglycerol)))))) (, ,) (NP (NP (DT the) (NN product)) (PP (IN of) (NP (NN _PROT2_)))))) |ET|
+1 |BT| (S1 (S (NP (DT This)) (ADVP (RB additionally)) (VP (VBZ supports) (NP (NP (DT the) (JJ inhibitory) (NN effect)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_)))) (PP (IN on) (NP (ADJP (ADJP (JJ membrane-bound)) (CC and) (ADJP (JJ cytosolic))) (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NP (NP (DT the) (JJ basal) (NN activity)) (PP (IN of) (NP (DT the) (NN _PROT2_))) (PP (IN in) (NP (NN SPM)))) (CC and) (NP (NP (DT the) (NN enzyme) (NN activity)) (VP (VBN regulated) (PP (IN through) (NP (JJ cholinergic) (NNS receptors))))))))) |ET|
-1 |BT| (S1 (S (NP (CD Ten) (NN _PROT1_) (NNS _PROT1_)) (VP (VBP have) (VP (VBN been) (VP (VBN assayed) (PP (IN for) (NP (PRP$ their) (NN ability) (S (VP (TO to) (VP (VB phosphorylate) (ADVP (FW in) (FW vitro)) (NP (NP (NP (DT the) (JJ _PROT2_) (JJ _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN 25-242)) (-RRB- -RRB-))) (PRN (-LRB- -LRB-) (NP (NN rbPrP)) (-RRB- -RRB-))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN With) (NN regard) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NN phosphorylation)) (VP (VBZ occurs) (PP (IN at) (NP (NN Ser) (CD 154))) (PP (IN with) (NP (NP (DT a) (NN stoichiometry)) (PP (IN of) (NP (QP (RB about) (CD 0.1)) (NN mol) (NN phosphate/mol) (NN _PROT2_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN doubled) (PP (IN by) (NP (NP (JJ mild) (NN heat) (NN treatment)) (PP (IN of) (NP (NN _PROT_)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN With) (NN regard) (TO to) (NP (NN _PROT1_))) (, ,) (NP (NN phosphorylation)) (VP (VBZ occurs) (PP (IN at) (NP (NN Ser) (CD 154))) (PP (IN with) (NP (NP (DT a) (NN stoichiometry)) (PP (IN of) (NP (QP (RB about) (CD 0.1)) (NN mol) (NN phosphate/mol) (NN _PROT_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN doubled) (PP (IN by) (NP (NP (JJ mild) (NN heat) (NN treatment)) (PP (IN of) (NP (NN _PROT2_)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN With) (NN regard) (TO to) (NP (NN _PROT_))) (, ,) (NP (NN phosphorylation)) (VP (VBZ occurs) (PP (IN at) (NP (NN Ser) (CD 154))) (PP (IN with) (NP (NP (DT a) (NN stoichiometry)) (PP (IN of) (NP (QP (RB about) (CD 0.1)) (NN mol) (NN phosphate/mol) (NN _PROT1_))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (VP (VBN doubled) (PP (IN by) (NP (NP (JJ mild) (NN heat) (NN treatment)) (PP (IN of) (NP (NN _PROT2_)))))))))))))) |ET|
+1 |BT| (S1 (S (IN In) (S (NP (NP (DT the) (JJ fasting) (NN state)) (NN _PROT1_) (NN expression)) (VP (VBD correlated) (ADVP (RB inversely)) (PP (IN with) (NP (NP (NP (NN body) (NN mass) (NN index)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.45)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.026)))) (-RRB- -RRB-))) (, ,) (NP (NP (JJ percent) (NN body) (NN fat)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.41)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.05)))) (-RRB- -RRB-))) (, ,) (NP (NP (NN plasma) (NN insulin)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.47)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.02)))) (-RRB- -RRB-))) (, ,) (NP (NP (JJ epigastric) (JJ venous) (JJ fatty) (NNS acids)) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.45)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.04)))) (-RRB- -RRB-))) (, ,) (CC and) (NP (NN _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (VP (VBG =) (NP (CD -0.50)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.018)))) (-RRB- -RRB-)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN expression)) (VP (VBD remained) (ADJP (RB inversely) (JJ related) (PP (IN with) (NP (NN plasma) (NN _PROT2_)))) (PP (IN after) (S (VP (VBG controlling) (PP (IN for) (NP (JJ percent) (NN body)))))) (PRN (-LRB- -LRB-) (NP (NP (NN r)) (ADJP (JJ =) (NP (CD -0.45)))) (: ;) (S (NP (NN P)) (VP (JJ =) (NP (CD 0.038)))) (-RRB- -RRB-))))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (LST (LS 1) (-RRB- -RRB-)) (NP (NP (NN _PROT1_) (NN messenger) (NN ribonucleic) (NN acid) (NN expression)) (PP (IN in) (NP (JJ sc) (NN adipose) (NN tissue)))) (VP (VP (VBZ is) (ADJP (RB inversely) (JJ related) (PP (TO to) (NP (NN adiposity))))) (CC and) (VP (ADVP (RB independently)) (VBN linked) (PP (TO to) (NP (JJ local) (NN plasma) (NN _PROT2_) (NNS levels)))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN _PROT_) (NN expression)) (VP (VBZ is) (RB not) (ADVP (RB acutely)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN food) (NN intake)) (, ,) (NP (NN insulin)) (, ,) (CC or) (NP (JJ fatty) (NNS acids))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (LST (LS 1) (-RRB- -RRB-)) (NP (NP (NN _PROT1_) (NN messenger) (NN ribonucleic) (NN acid) (NN expression)) (PP (IN in) (NP (JJ sc) (NN adipose) (NN tissue)))) (VP (VP (VBZ is) (ADJP (RB inversely) (JJ related) (PP (TO to) (NP (NN adiposity))))) (CC and) (VP (ADVP (RB independently)) (VBN linked) (PP (TO to) (NP (JJ local) (NN plasma) (NN _PROT_) (NNS levels)))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (RB not) (ADVP (RB acutely)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN food) (NN intake)) (, ,) (NP (NN insulin)) (, ,) (CC or) (NP (JJ fatty) (NNS acids))))))))) |ET|
-1 |BT| (S1 (S (S (PP (IN In) (NP (NN conclusion))) (, ,) (LST (LS 1) (-RRB- -RRB-)) (NP (NP (NN _PROT_) (NN messenger) (NN ribonucleic) (NN acid) (NN expression)) (PP (IN in) (NP (JJ sc) (NN adipose) (NN tissue)))) (VP (VP (VBZ is) (ADJP (RB inversely) (JJ related) (PP (TO to) (NP (NN adiposity))))) (CC and) (VP (ADVP (RB independently)) (VBN linked) (PP (TO to) (NP (JJ local) (NN plasma) (NN _PROT1_) (NNS levels)))))) (: ;) (CC and) (LST (LS 2) (-RRB- -RRB-)) (S (NP (NN _PROT2_) (NN expression)) (VP (VBZ is) (RB not) (ADVP (RB acutely)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN food) (NN intake)) (, ,) (NP (NN insulin)) (, ,) (CC or) (NP (JJ fatty) (NNS acids))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN Influence)) (PP (IN of) (NP (NP (NN obesity)) (CC and) (NP (JJ menopausal) (NN status)))) (PP (IN on) (NP (NP (NP (NN serum) (NN _PROT1_)) (, ,) (NP (NN cholecystokinin)) (, ,) (NP (NN galanin)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (NNS levels)))))) |ET|
-1 |BT| (S1 (S (NP (NN Obesity)) (VP (VP (VBZ occurs) (PP (IN in) (NP (NP (CD 60) (NN %)) (PP (IN of) (NP (NP (NNS women)) (PP (IN after) (NP (NN menopause)))))))) (CC and) (VP (VBZ is) (VP (VBN characterized) (PP (IN by) (NP (NP (DT an) (NN excess)) (PP (IN of) (NP (NN adipose) (NN tissue)))))))) (SBAR (WHNP (WDT that)) (S (VP (VBZ depends) (PP (IN on) (NP (JJ several) (ADJP (ADJP (ADJP (JJ orexigenic)) (PRN (-LRB- -LRB-) (S (S (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (VP (VBZ stimulates) (NP (NN carbohydrate) (NN ingestion)))) (, ,) (S (NP (NN galanin)) (VP (VBZ stimulates) (NP (JJ fat) (NN intake))))) (-RRB- -RRB-))) (CC and) (ADJP (ADJP (JJ anorectic)) (PRN (-LRB- -LRB-) (NP (NP (NN _PROT2_)) (, ,) (NP (NP (NN cholecystokinin)) (PRN (-LRB- -LRB-) (NP (NN CCK)) (-RRB- -RRB-)))) (-RRB- -RRB-)))) (NNS factors)))))))) |ET|
+1 |BT| (S1 (S (NP (CC Both) (NP (NN _PROT1_)) (CC and) (NP (NN insulin))) (VP (MD can) (VP (VB reduce) (NP (NP (JJ hypothalamic) (NN _PROT2_) (NN production)) (CC and) (NP (NN secretion))))))) |ET|
-1 |BT| (S1 (S (S (NP (PRP We)) (VP (VBD investigated) (NP (NP (JJ basal) (NNS levels)) (PP (IN of) (NP (NP (NP (NN serum) (NN _PROT1_)) (, ,) (NP (NN CCK)) (, ,) (NP (NN galanin)) (CC and) (NP (NN _PROT2_))) (PP (PP (IN in) (NP (CD 16) (JJ non-obese) (JJ premenopausal) (NNS women))) (, ,) (PP (IN in) (NP (NP (CD 15) (JJ obese) (JJ premenopausal) (NNS women)) (PRN (-LRB- -LRB-) (NP (NN body) (NN mass) (NN index) (-LRB- -LRB-) (NN BMI) (-RRB- -RRB-) (QP (CD 34.6) (CC +/-) (CD 1.3)) (NN SD)) (-RRB- -RRB-)))) (CC and) (PP (IN in) (NP (NP (CD ten) (JJ obese) (JJ postmenopausal) (NNS women)) (PRN (-LRB- -LRB-) (NP (NN BMI) (CD 34.7) (CC +/-) (CD 1.5) (NN SD)) (-RRB- -RRB-)))))))))) (S (VP (TO to) (VP (VB determine) (NP (DT the) (NN relationship)) (PP (IN between) (NP (NP (NN obesity)) (, ,) (NP (NN menopause)) (CC and) (NP (DT these) (NNS neuropeptides))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (ADJP (RB Significantly) (VBN increased)) (NP (NP (NN _PROT1_)) (CC and) (NP (NN galanin))) (NNS levels)) (PP (IN in) (NP (NP (JJ postmenopausal) (JJ obese) (NNS women)) (VP (VBN coupled) (PP (IN with) (NP (VBN decreased) (NN _PROT2_) (NNS levels))))))) (VP (VBD revealed) (NP (NP (DT some) (NNS changes)) (PP (IN in) (NP (NP (DT the) (NNS neuropeptides)) (VP (VBG regulating) (NP (JJ eating) (NN behavior))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (MD may) (VP (VB be) (NP (NP (DT the) (NN reason)) (PP (IN for) (NP (NP (DT the) (NN onset)) (PP (IN of) (NP (JJ postmenopausal) (NN obesity)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT A) (NN loop) (NN system)) (VP (VBZ exists) (PP (IN between) (NP (NP (NP (JJ hypothalamic) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC and) (NP (JJ peripheral) (NN adipose) (NN tissue) (NN _PROT2_)))) (S (VP (TO to) (VP (VB maintain) (NP (JJ normal) (NN body) (NN homeostasis)))))))) |ET|
+1 |BT| (S1 (S (SBAR (WHADVP (WRB When)) (S (VP (VBN infused) (NP (NN i.c.v.)) (PP (TO to) (NP (JJ normal) (NNS rats))) (S (VP (TO to) (VP (VB mimic) (NP (PRP$ its) (JJ central) (NNS effects)))))))) (, ,) (S (NP (NN _PROT1_)) (VP (VBZ decreases) (NP (NP (NN _PROT2_) (NNS levels)) (, ,) (ADVP (RB thus)) (NP (NP (NN food) (NN intake)) (CC and) (NP (NN body) (NN weight)))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Circadian) (NNS fluctuations)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))) (NNS levels)))) (VP (VBP maintain) (NP (JJ normal) (NN body) (NN homeostasis))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VP (VBZ increases) (NP (NP (DT the) (NN expression)) (PP (IN of) (NP (NN _PROT2_) (NNS _PROT2_)))) (PRN (-LRB- -LRB-) (NP (NP (NN UCP-1)) (, ,) (NP (CD -2)) (, ,) (NP (CD -3))) (-RRB- -RRB-))) (CC and) (VP (ADVP (RB thus)) (NP (NN energy) (NN dissipation)))))) |ET|
+1 |BT| (S1 (S (PP (VBN Compared) (PP (IN with) (NP (DT the) (JJ wild) (NN type)))) (, ,) (NP (NP (NN _PROT1_) (NN induction)) (PP (IN of) (NP (JJ _PROT2_) (NN activity))) (PP (IN in) (NP (NP (NN aleurone) (NNS cells)) (PP (IN of) (NP (NN d1)))))) (VP (VBD was) (ADVP (RB greatly)) (VP (VBN reduced))))) |ET|
+1 |BT| (S1 (S (PP (JJ Relative) (TO to) (NP (DT the) (JJ wild) (NN type))) (, ,) (NP (NP (DT the) (NN _PROT1_) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-) (JJ -treated) (NN aleurone) (NN layer)) (PP (IN of) (NP (NN d1)))) (VP (VBD had) (NP (NP (JJR lower) (NN expression)) (PP (IN of) (NP (NN Ramy1A))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (NP (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN OsGAMYB))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (DT a) (JJ _PROT_) (JJ transcriptional) (NN factor))))) (, ,)) (CC and) (NP (NP (DT no) (NN increase)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN Ca)) (PRN (-LRB- -LRB-) (NP (CD 2)) (CC +) (-RRB- -RRB-))) (NN -ATPase)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (JJ Relative) (TO to) (NP (DT the) (JJ wild) (NN type))) (, ,) (NP (NP (DT the) (NN _PROT1_) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-) (JJ -treated) (NN aleurone) (NN layer)) (PP (IN of) (NP (NN d1)))) (VP (VBD had) (NP (NP (JJR lower) (NN expression)) (PP (IN of) (NP (NN Ramy1A))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (NP (NP (NN _PROT_)) (, ,) (CC and) (NP (NN OsGAMYB))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (DT a) (JJ _PROT2_) (JJ transcriptional) (NN factor))))) (, ,)) (CC and) (NP (NP (DT no) (NN increase)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN Ca)) (PRN (-LRB- -LRB-) (NP (CD 2)) (CC +) (-RRB- -RRB-))) (NN -ATPase)))))))))))))) |ET|
-1 |BT| (S1 (S (PP (JJ Relative) (TO to) (NP (DT the) (JJ wild) (NN type))) (, ,) (NP (NP (DT the) (NN _PROT_) (-LRB- -LRB-) (CD 3) (-RRB- -RRB-) (JJ -treated) (NN aleurone) (NN layer)) (PP (IN of) (NP (NN d1)))) (VP (VBD had) (NP (NP (JJR lower) (NN expression)) (PP (IN of) (NP (NN Ramy1A))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (NP (NP (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN OsGAMYB))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ encodes) (NP (DT a) (JJ _PROT2_) (JJ transcriptional) (NN factor))))) (, ,)) (CC and) (NP (NP (DT no) (NN increase)) (PP (IN in) (NP (NP (NN expression)) (PP (IN of) (NP (NP (NP (NN Ca)) (PRN (-LRB- -LRB-) (NP (CD 2)) (CC +) (-RRB- -RRB-))) (NN -ATPase)))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB However)) (, ,) (PP (IN in) (DT the) (NN presence) (IN of) (NP (JJ high) (NN _PROT1_) (NNS concentrations))) (, ,) (NP (NN _PROT2_) (NN induction)) (VP (VBD occurred) (ADVP (RB even)) (PP (IN in) (NP (NN d1)))))) |ET|
+1 |BT| (S1 (S (NP (PDT All) (DT these) (NNS results)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NN d1)) (VP (VBZ affects) (NP (NP (NP (DT a) (NN part)) (PP (IN of) (NP (DT the) (JJ _PROT1_) (NN pathway)))) (, ,) (NP (NP (RB namely) (DT the) (NN induction)) (PP (IN of) (NP (NN _PROT2_))) (PP (IN in) (NP (DT the) (NN aleurone) (NN layer)))) (CC and) (NP (NN internode) (NN elongation))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Arcuate) (NN nucleus) (NN _PROT1_) (NN mRNA)) (VP (VBD increased) (PP (IN in) (NP (NP (NNS rats)) (PP (IN given) (NP (JJ protein-free) (NN diet))))) (, ,) (S (VP (VBG correlating) (PP (IN with) (NP (NP (NN _PROT2_)) (CONJP (RB rather) (IN than)) (NP (VBN decreased) (NN feeding))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Granulosa) (NNS cells)) (VP (VBD were) (VP (VP (VBN isolated) (PP (IN from) (NP (JJ bovine) (JJ preovulatory) (NNS follicles)))) (CC and) (VP (VBN cultured) (PP (IN for) (NP (NP (CD 3) (NNS days)) (PP (IN with) (CC or) (PP (IN without) (NP (NN _PROT1_)))))) (PP (IN in) (NP (NP (NP (NP (NN medium)) (VP (VBN supplemented) (PP (IN with) (NP (CC either) (NP (NP (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (CD 1) (NN microgram/ml)) (-RRB- -RRB-))) (CC +) (NP (ADJP (CD 1) (NN %)) (NP (NP (JJ fetal) (NN calf) (NN serum)) (PRN (-LRB- -LRB-) (NP (NN FCS)) (-RRB- -RRB-))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ maintains) (NP (JJ basal) (NN estradiol) (NN secretion))))) (, ,)) (CC or) (NP (NP (JJ low) (NNS doses)) (PP (IN of) (NP (NP (NN FSH)) (PRN (-LRB- -LRB-) (NP (QP (CD 1) (CC and) (CD 2)) (NN ng/ml)) (-RRB- -RRB-))))))))) (CC +) (NP (ADJP (CD 1) (NN %)) (NN FCS))) (, ,) (NP (NP (DT a) (NN culture) (NN condition)) (SBAR (WHNP (WDT that)) (S (VP (VBZ maximizes) (NP (NP (NNS effects)) (PP (IN of) (NP (NN FSH))) (PP (IN on) (NP (NN estradiol) (NN secretion))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Wortmannin)) (VP (VBZ converts) (NP (NP (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_))) (PP (IN from) (NP (DT an) (JJ antilipolytic))) (PP (TO to) (NP (NP (DT a) (JJ lipolytic) (NN agent)) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (NN forskolin)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NNS studies)) (VP (VBD compared) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN rat) (NNS adipocytes)))) (PP (IN with) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT2_)) (CC and) (NP (NN peroxovanadate)))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP mimic) (NP (NP (DT some) (NNS effects)) (PP (IN of) (NP (NN _PROT_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NNS studies)) (VP (VBD compared) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NN rat) (NNS adipocytes)))) (PP (IN with) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT_)) (CC and) (NP (NN peroxovanadate)))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP mimic) (NP (NP (DT some) (NNS effects)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (JJ present) (NNS studies)) (VP (VBD compared) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NN rat) (NNS adipocytes)))) (PP (IN with) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NN peroxovanadate)))))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP mimic) (NP (NP (DT some) (NNS effects)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ antilipolytic) (NNS effects)) (PP (IN of) (NP (NP (NN peroxovanadate)) (CC and) (NP (NN _PROT1_))))) (VP (VBD were) (VP (VBN unaffected) (PP (IN by) (NP (ADJP (CD 500) (NN nmol/L)) (NN wortmannin)))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBD blocked) (NP (NP (DT the) (JJ antilipolytic) (NN action)) (PP (IN of) (NP (NN _PROT2_)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP provide) (NP (NP (JJ additional) (NN support)) (PP (IN for) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN peroxovanadate))) (VP (VBP affect) (NP (NN adipose) (NN tissue) (NN metabolism)) (PP (IN by) (NP (NP (NNS mechanisms)) (ADJP (RB distinctly) (JJ different) (PP (IN from) (NP (NP (DT those)) (VP (VBN involved) (PP (IN in) (NP (NN _PROT2_) (NN action)))))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN effect)) (VP (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (NP (CD 10) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN M)) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN concentration)) (PP (ADVP (RB clearly)) (IN above) (NP (NP (DT the) (JJ normal) (JJ physiological) (NN range)) (PP (IN of) (NP (NN _PROT1_) (NNS concentrations)))))) (-RRB- -RRB-))))))) (CC and) (VP (VBZ involves) (NP (DT the) (NN V2) (NN receptor) (NN pathway)) (, ,) (SBAR (IN while) (S (NP (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (CC or) (NP (NP (NNS changes)) (PP (IN in) (NP (JJ intracellular) (NN calcium))))) (VP (VBP are) (NP (JJ ineffective))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN effect)) (VP (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (NP (CD 10) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN M)) (NP (NP (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN concentration)) (PP (ADVP (RB clearly)) (IN above) (NP (NP (DT the) (JJ normal) (JJ physiological) (NN range)) (PP (IN of) (NP (NN _PROT1_) (NNS concentrations)))))) (-RRB- -RRB-))))))) (CC and) (VP (VBZ involves) (NP (DT the) (NN V2) (NN receptor) (NN pathway)) (, ,) (SBAR (IN while) (S (NP (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (CC or) (NP (NP (NNS changes)) (PP (IN in) (NP (JJ intracellular) (NN calcium))))) (VP (VBP are) (NP (JJ ineffective))))))))) |ET|
-1 |BT| (S1 (S (NP (DT This) (NN effect)) (VP (VP (VBZ is) (ADJP (JJ maximal) (PP (IN at) (NP (NP (CD 10) (-LRB- -LRB-) (CD -8) (-RRB- -RRB-) (NN M)) (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN concentration)) (PP (ADVP (RB clearly)) (IN above) (NP (NP (DT the) (JJ normal) (JJ physiological) (NN range)) (PP (IN of) (NP (NN _PROT_) (NNS concentrations)))))) (-RRB- -RRB-))))))) (CC and) (VP (VBZ involves) (NP (DT the) (NN V2) (NN receptor) (NN pathway)) (, ,) (SBAR (IN while) (S (NP (NP (NP (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (CC or) (NP (NP (NNS changes)) (PP (IN in) (NP (JJ intracellular) (NN calcium))))) (VP (VBP are) (NP (JJ ineffective))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Activation)) (PP (IN of) (NP (NN EGFR) (VBG overexpressing) (NN 3T3-L1) (NNS adipocytes)))) (VP (VBZ leads) (PP (TO to) (NP (NP (NP (DT a) (ADJP (ADJP (CD 3.4)) (CC +/-) (ADJP (JJ 1.2-fold))) (NN stimulation)) (PP (IN of) (NP (NP (NN _PROT1_) (NN activity)) (PP (IN over) (NP (JJ basal) (NNS levels)))))) (CC vs.) (NP (NP (QP (RB only) (CD 1.06) (CC +/-) (CD 0.01-fold)) (NN stimulation)) (PP (IN by) (NP (NN _PROT2_))))))) (. .))) |ET|
+1 |BT| (S1 (S (PP (IN Despite) (NP (NP (DT the) (JJ low) (NNS levels)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT2_) (NN activity))))) (, ,) (NP (JJ _PROT_) (NN glucose) (NN transport) (NN activity)) (VP (VBD was) (ADVP (RB similarly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN U73122)) (PRN (-LRB- -LRB-) (NP (QP (CD 55.9) (CC +/-) (CD 13.1)) (NN %) (NN inhibition)) (-RRB- -RRB-)))))))) |ET|
-1 |BT| (S1 (S (PP (IN Despite) (NP (NP (DT the) (JJ low) (NNS levels)) (PP (IN of) (NP (JJ _PROT1_) (NN _PROT_) (NN activity))))) (, ,) (NP (JJ _PROT2_) (NN glucose) (NN transport) (NN activity)) (VP (VBD was) (ADVP (RB similarly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN U73122)) (PRN (-LRB- -LRB-) (NP (QP (CD 55.9) (CC +/-) (CD 13.1)) (NN %) (NN inhibition)) (-RRB- -RRB-)))))))) |ET|
-1 |BT| (S1 (S (PP (IN Despite) (NP (NP (DT the) (JJ low) (NNS levels)) (PP (IN of) (NP (JJ _PROT_) (NN _PROT1_) (NN activity))))) (, ,) (NP (JJ _PROT2_) (NN glucose) (NN transport) (NN activity)) (VP (VBD was) (ADVP (RB similarly)) (VP (VBN inhibited) (PP (IN by) (NP (NP (NN U73122)) (PRN (-LRB- -LRB-) (NP (QP (CD 55.9) (CC +/-) (CD 13.1)) (NN %) (NN inhibition)) (-RRB- -RRB-)))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN activation)))) (VP (VBD did) (RB not) (VP (VB impair) (NP (CC either) (NP (NP (NP (NN EGF-)) (CC or) (NP (JJ _PROT2_) (NN activation))) (PP (IN of) (NP (NN glycogen) (NN synthase)))) (CC or) (NP (NP (NN incorporation)) (PP (IN of) (NP (NN glucose))) (PP (IN into) (NP (NN lipid))))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (CC both) (NP (NN EGF-)) (CC and) (NP (JJ _PROT_) (NN glucose) (NN disposal))) (VP (MD can) (VP (VB be) (ADJP (JJ independent) (PP (IN of) (NP (JJ GLUT4-mediated) (NN glucose) (NN transport)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN activation)))) (VP (VBD did) (RB not) (VP (VB impair) (NP (CC either) (NP (NP (NP (NN EGF-)) (CC or) (NP (JJ _PROT_) (NN activation))) (PP (IN of) (NP (NN glycogen) (NN synthase)))) (CC or) (NP (NP (NN incorporation)) (PP (IN of) (NP (NN glucose))) (PP (IN into) (NP (NN lipid))))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (CC both) (NP (NN EGF-)) (CC and) (NP (JJ _PROT2_) (NN glucose) (NN disposal))) (VP (MD can) (VP (VB be) (ADJP (JJ independent) (PP (IN of) (NP (JJ GLUT4-mediated) (NN glucose) (NN transport)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Inhibition)) (PP (IN of) (NP (NN _PROT_) (NN activation)))) (VP (VBD did) (RB not) (VP (VB impair) (NP (CC either) (NP (NP (NP (NN EGF-)) (CC or) (NP (JJ _PROT1_) (NN activation))) (PP (IN of) (NP (NN glycogen) (NN synthase)))) (CC or) (NP (NP (NN incorporation)) (PP (IN of) (NP (NN glucose))) (PP (IN into) (NP (NN lipid))))) (, ,) (S (VP (VBG supporting) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (CC both) (NP (NN EGF-)) (CC and) (NP (JJ _PROT2_) (NN glucose) (NN disposal))) (VP (MD can) (VP (VB be) (ADJP (JJ independent) (PP (IN of) (NP (JJ GLUT4-mediated) (NN glucose) (NN transport)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (NN diminution)) (PP (IN of) (NP (NP (NN glucose) (NN transport)) (ADJP (JJ secondary) (PP (TO to) (NP (NP (NN inhibition)) (PP (IN of) (NP (NN _PROT1_) (NN activity))))))))) (VP (VBD was) (VP (VBN reflected) (PP (IN by) (NP (NP (DT a) (NN decrease)) (PP (IN in) (NP (NP (NN GLUT4) (NN translocation)) (PP (TO to) (NP (DT the) (NN plasma) (NN membrane))))))) (PP (IN upon) (NP (CC either) (NP (NN EGF)) (CC or) (NP (NN _PROT2_) (NN stimulation)))))))) |ET|
+1 |BT| (S1 (S (NP (JJ _PROT1_) (JJ male) (NNS rats)) (VP (VBD had) (NP (NP (NP (VBN increased) (VBG circulating) (NNS levels)) (PP (IN of) (NP (NN cholecystokinin)))) (, ,) (NP (NP (DT a) (NN tendency)) (PP (TO to) (NP (NP (VBN increased) (NN plasma) (NNS levels)) (PP (IN of) (NP (NP (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN p) (JJ =) (CD 0.066)) (-RRB- -RRB-))))))) (, ,) (CC and) (NP (NP (ADJP (RB relatively) (JJR more)) (NN adipose) (NN tissue)) (PP (IN in) (NP (DT the) (NP (NN thigh)) (CC and) (NP (JJ interscapular) (NN region)))))) (, ,) (PP (VBN compared) (PP (IN with) (NP (NNS controls))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ _PROT1_) (NN activation)) (PP (IN of) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (JJ renal) (JJ epithelial) (NNS cells)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD induced) (NP (NP (DT a) (JJ biphasic) (NN increase)) (PP (IN in) (NP (NN diacylglycerol) (NN generation))) (, ,) (VP (VBN characterized) (PP (IN by) (NP (NP (DT an) (JJ initial) (JJ rapid) (NN rise)) (CC and) (RB then) (NP (DT a) (JJ sustained) (NN elevation)) (, ,) (CC and) (NP (NN _PROT2_) (NN activation))))) (, ,) (VP (VBN reflected) (PP (IN by) (NP (NP (NN phosphorylation)) (PP (IN of) (NP (NP (DT a) (JJ specific) (ADJP (NP (CD 80) (NN kDa)) (VBN myristoylated)) (JJ alanine-rich) (NN PKC) (NN substrate)) (PRN (-LRB- -LRB-) (NP (NN MARCKS)) (-RRB- -RRB-))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP argue) (SBAR (SBAR (IN that) (S (NP (ADJP (NN Ca) (-LRB- -LRB-) (NN 2+) (-RRB- -RRB-) (JJ -dependent)) (NN _PROT1_)) (VP (VBZ is) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (NN _PROT2_))))))))) (, ,) (CC and) (SBAR (IN that) (S (PP (IN of) (NP (JJ other) (NNS agonists))) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBP stimulate) (NP (NN sodium) (NN transport))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN During) (NP (NN wk) (CD 6))) (, ,) (S (S (NP (NP (NN milk) (NN yield)) (CC and) (NP (NP (JJ dry) (NN matter) (NN intake)) (PRN (-LRB- -LRB-) (NP (NN DMI)) (-RRB- -RRB-)))) (VP (VBD were) (VP (VBN recorded) (ADVP (RB daily))))) (, ,) (CC and) (S (NP (NP (NN plasma) (NNS concentrations)) (PP (IN of) (NP (NP (NN glucose)) (, ,) (NP (JJ nonesterified) (JJ fatty) (NNS acids)) (, ,) (NP (NN urea)) (, ,) (NP (NN protein)) (, ,) (NP (NN growth) (NN hormone)) (, ,) (NP (NN _PROT1_)) (, ,) (NP (JJ insulin-like) (NN growth) (NN factor) (CD I)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN prolactin))))) (VP (VBD were) (VP (VBN determined))))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Concurrent) (NN decrease)) (PP (IN of) (NP (NP (NN _PROT1_)) (CC and) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NN immunoreactivity)))) (PP (IN during) (NP (DT the) (JJ light) (NN phase))) (PP (IN in) (NP (DT the) (JJ vole) (JJ suprachiasmatic) (NN nucleus)))))) |ET|
-1 |BT| (S1 (S (NP (NP (JJ Mean) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (JJ _PROT2_) (NNS neurons)))) (VP (VBD were) (VP (VBN determined) (PP (IN in) (NP (NP (DT the) (JJ suprachiasmatic) (NN nucleus)) (PP (IN of) (NP (NP (JJ common) (NNS voles)) (, ,) (VP (VBN entrained) (PP (TO to) (NP (DT a) (ADJP (CD 12:12) (NN h)) (NN light-dark) (-LRB- -LRB-) (NN LD) (-RRB- -RRB-) (NN cycle)))))))) (, ,) (PP (IN at) (NP (NP (DT the) (NN beginning)) (PP (IN of) (NP (NP (NP (NP (DT the) (JJ light) (NN period)) (PRN (-LRB- -LRB-) (NP (NN zeitgeber) (NN time) (CD zero)) (-RRB- -RRB-))) (CC and) (NP (NP (CD 6) (NN h)) (ADVP (RB later)))) (PRN (-LRB- -LRB-) (NP (NN zeitgeber) (NN time) (CD six)) (-RRB- -RRB-)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN At) (NP (NN zeitgeber) (NN time) (CD zero))) (, ,) (NP (NP (JJ mean) (NNS numbers)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (JJ _PROT2_) (JJ immunoreactive) (NNS neurons)))) (VP (VBD were) (NP (NP (CD 2194)) (CC and) (NP (CD 9897))) (, ,) (ADVP (RB respectively))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN distribution)) (PP (IN of) (NP (NP (NP (NP (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (NNS cells)) (PP (IN in) (NP (DT the) (NNS SCN)))))) (VP (VBD overlapped) (PP (IN with) (NP (NP (DT that)) (PP (IN of) (NP (NN _PROT2_))))) (PP (IN in) (NP (DT both) (NNS species)))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS Species) (NNS differences)) (PP (IN in) (NP (NP (DT the) (NN location)) (PP (IN of) (NP (DT the) (JJ Ca2+-dependent) (NN _PROT1_) (NNS isoforms)))))) (VP (VBP suggest) (NP (NP (NP (NNS differences)) (PP (IN in) (NP (NP (NN function)) (PP (JJ such) (IN as) (NP (NP (DT the) (VBG relaying)) (PP (IN of) (NP (ADJP (ADJP (JJ photic)) (CC or) (ADJP (JJ non-photic))) (NN information))) (PP (TO to) (NP (DT the) (JJ clock) (NN mechanism)))))))) (, ,) (CC or) (NP (NP (DT the) (NN synchronization)) (PP (IN of) (NP (NN _PROT2_) (NNS neurons)))) (CC and) (NP (PRP$ their) (JJ subsequent) (NN output) (NNS signals)))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (CD two) (NNS groups)) (VP (VBD were) (ADJP (JJ similar)) (PP (IN in) (NP (NP (PRP$ their) (NN morning) (NN thyroxin)) (, ,) (NP (NN triiodothyronine)) (, ,) (NP (NN TSH)) (, ,) (NP (NN estradiol) (, ,) (NN cortisol) (, ,) (NN gastrin) (, ,) (NN cholecystokinin) (, ,) (NN somatostatin) (, ,) (NN _PROT1_) (, ,) (NN _PROT2_) (CC and) (NN IGF-1) (NNS levels))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (VBN deduced) (NN consensus)) (ADVP (RB closely)) (VP (VBD resembled) (NP (NP (NN _PROT1_) (NN response) (NNS elements)) (PP (IN in) (NP (NN _PROT2_) (NNS promoters))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NP (NN Phorbol) (NN myristate) (NN acetate)) (PRN (-LRB- -LRB-) (NP (NN TPA)) (-RRB- -RRB-))) (, ,) (NP (NP (DT an) (NN activator)) (PP (IN of) (NP (NN _PROT1_)))) (, ,)) (VP (VP (VBD elicited) (NP (NP (DT an) (NN increase)) (PP (IN of) (NP (NN MAPK) (NN activity))))) (, ,) (CC but) (VP (VBD did) (RB not) (ADVP (RB further)) (VP (VB influence) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (JJ _PROT2_) (NN MAPK) (NN activity)))))))) (: ;) (S (ADVP (RB Nevertheless)) (, ,) (NP (NP (DT the) (NN extent)) (PP (IN of) (NP (NN CaMKII) (NN activation)))) (VP (VBD was) (VP (VBN attenuated) (PP (IN by) (NP (NN TPA)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (DT A) (JJ neurotoxic) (NN fragment)) (PP (IN of) (NP (NN _PROT1_)))) (, ,) (NP (NP (NNP Abeta) (CD 25-35)) (, ,) (VP (VBN incubated) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (JJ endogenous) (NN Ca2+))))))) (, ,)) (VP (VBD increased) (ADVP (RB significantly)) (NP (NP (DT the) (NN _PROT2_) (NN activity)) (PP (IN of) (NP (JJ normoxic) (NN brain))))))) |ET|
+1 |BT| (S1 (S (S (PP (IN In) (NP (PRP$ its) (JJ non-aggregated) (NN form))) (, ,) (NP (NNP _PROT1_) (CD _PROT1_)) (VP (VBZ activates) (NP (NN _PROT2_)) (PP (CC but) (IN in) (NP (DT the) (VBN aggregated) (NN form))))) (S (NP (DT the) (JJ enzymatic) (NN activity)) (VP (VBD decreased))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (NP (NN _PROT1_) (CD _PROT1_)) (VP (VP (VBZ exerts) (NP (DT a) (JJ similar) (NN effect)) (PP (IN on) (NP (NP (DT the) (JJ membrane-bound) (NN _PROT2_)) (PP (IN from) (NP (JJ normoxic) (NN brain)))))) (CC or) (VP (VBN subjected) (PP (TO to) (NP (NN ischemia) (NN reperfusion) (NN injury))))))) |ET|
+1 |BT| (S1 (S (NP (NN Ischemia-reperfusion) (NN injury)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ _PROT1_) (NNS alterations)) (PP (IN of) (NP (JJ synaptic) (NN plasma) (JJ membrane-bound) (NN _PROT2_)))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN _PROT1_) (NN beta) (NN peptide) (CD 25-35)) (VP (VBZ modulates) (NP (NP (NN hydrolysis)) (PP (IN of) (NP (NNS phosphoinositides)))) (PP (IN by) (NP (NP (NN membrane) (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (NN _PROT2_)) (PP (IN of) (NP (JJ adult) (NN brain) (NN cortex))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NN Fresh-water-soluble) (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD activated) (NP (NP (NN _PROT2_)) (PP (IN in) (NP (NN SPM)))) (ADVP (RB markedly)) (PP (IN by) (NP (CD two-) (TO to) (JJ threefold))))) (, ,) (CC but) (S (NP (DT this) (NN effect)) (VP (VBD was) (ADJP (JJ absent) (PP (IN in) (NP (NP (DT the) (NN presence)) (PP (IN of) (NP (ADJP (CD 2) (NN mM)) (NN CaCl2)))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT2_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT1_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT2_)) (CC and) (NP (NN _PROT_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT1_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Moreover)) (, ,) (NP (NN _PROT_) (NN _PROT_) (CD 25-35)) (VP (VBD had) (NP (DT no) (NN effect)) (PP (IN on) (NP (NP (JJ basal) (NN _PROT_) (NN activity)) (CC and) (NP (JJ cytosolic) (NP (NP (NN _PROT1_)) (CC and) (NP (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ aggregated) (NN form)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_) (CD 25-35)))) (ADVP (RB significantly)) (VP (VBD inhibited) (NP (NN _PROT2_)) (PP (ADVP (RB only)) (IN in) (DT the) (NN presence) (IN of) (NP (JJ endogenous) (NN CaCl2)))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Hypothalamic) (NN _PROT1_) (NN _PROT1_)) (CC and) (NP (NP (PRP$ its) (JJ neuroendocrine) (NN regulation)) (PP (IN by) (NP (NN _PROT2_))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NN Relationship)) (PP (IN among) (NP (NP (NP (NN _PROT1_)) (, ,) (NP (NN _PROT2_) (NN _PROT2_)) (, ,) (CC and) (NP (NN galanin))) (PP (PP (IN in) (NP (JJ young) (NNS women))) (CC and) (PP (IN in) (NP (JJ postmenopausal) (NNS women))))))) (VP (VBD [see) (NP (NNS comments))) (-RRB- -RSB-))) |ET|
-1 |BT| (S1 (S (NP (NP (NN OBJECTIVE)) (: :) (S (VP (TO To) (VP (VB determine) (SBAR (IN whether) (S (NP (JJ hormonal) (NN status)) (VP (MD may) (VP (VB affect) (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (, ,) (NP (NN galanin)) (, ,) (CC and) (NP (NN _PROT2_) (NN release))) (PP (PP (IN in) (NP (JJ postmenopausal) (NNS women))) (CC and) (PP (IN in) (NP (JJ young) (NNS women))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (PRP$ Our) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NNS differences)) (VP (VBZ is) (NP (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN galanin))) (PP (IN between) (NP (NP (JJ postmenopausal) (NNS women)) (CC and) (NP (JJ young) (NNS women))))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (PP (TO to) (NP (NN body) (NN mass) (NN index))) (CONJP (RB rather) (IN than)) (PP (TO to) (NP (NP (NNS differences)) (PP (IN in) (NP (JJ hormonal) (NN status))))))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (JJR higher) (NN _PROT_) (NNS levels)) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (JJ postmenopausal) (NNS women))) (PP (IN than) (PP (IN in) (NP (JJ young) (NNS women))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS factors)) (CONJP (JJ other) (IN than)) (NP (NN body) (NN mass) (NN index))) (VP (MD may) (VP (VB be) (VP (VBN involved))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (PRP$ Our) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NNS differences)) (VP (VBZ is) (NP (NP (NP (NN plasma) (NN _PROT1_)) (, ,) (NP (NN _PROT_)) (, ,) (CC and) (NP (NN galanin))) (PP (IN between) (NP (NP (JJ postmenopausal) (NNS women)) (CC and) (NP (JJ young) (NNS women))))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (PP (TO to) (NP (NN body) (NN mass) (NN index))) (CONJP (RB rather) (IN than)) (PP (TO to) (NP (NP (NNS differences)) (PP (IN in) (NP (JJ hormonal) (NN status))))))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (JJR higher) (NN _PROT2_) (NNS levels)) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (JJ postmenopausal) (NNS women))) (PP (IN than) (PP (IN in) (NP (JJ young) (NNS women))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS factors)) (CONJP (JJ other) (IN than)) (NP (NN body) (NN mass) (NN index))) (VP (MD may) (VP (VB be) (VP (VBN involved))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NNS CONCLUSIONS)) (: :) (S (NP (PRP$ Our) (NNS results)) (VP (VBP suggest) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (NNS differences)) (VP (VBZ is) (NP (NP (NP (NN plasma) (NN _PROT_)) (, ,) (NP (NN _PROT1_)) (, ,) (CC and) (NP (NN galanin))) (PP (IN between) (NP (NP (JJ postmenopausal) (NNS women)) (CC and) (NP (JJ young) (NNS women))))))) (VP (MD may) (VP (VB be) (ADJP (JJ related) (PP (PP (TO to) (NP (NN body) (NN mass) (NN index))) (CONJP (RB rather) (IN than)) (PP (TO to) (NP (NP (NNS differences)) (PP (IN in) (NP (JJ hormonal) (NN status))))))))))) (CC and) (SBAR (IN that) (S (NP (NP (DT the) (JJR higher) (NN _PROT2_) (NNS levels)) (PP (IN in) (NP (ADJP (CC both) (ADJP (JJ lean)) (CC and) (ADJP (JJ obese))) (JJ postmenopausal) (NNS women))) (PP (IN than) (PP (IN in) (NP (JJ young) (NNS women))))) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (NNS factors)) (CONJP (JJ other) (IN than)) (NP (NN body) (NN mass) (NN index))) (VP (MD may) (VP (VB be) (VP (VBN involved))))))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Thus)) (, ,) (S (ADVP (RB highly)) (VP (VBN expressed) (PP (IN in) (NP (JJ human) (NNS adipocytes))))) (, ,) (NP (DT the) (NN Y) (-LRB- -LRB-) (CD 1) (-RRB- -RRB-) (NN receptor)) (VP (VP (VBZ sustains) (NP (NP (DT the) (JJ strong) (JJ antilipolytic) (NN effect)) (PP (IN of) (NP (NN _PROT1_))))) (CC and) (VP (VBZ exerts) (NP (NP (DT a) (JJ positive) (NN action)) (PP (IN on) (NP (NN _PROT2_) (NN secretion)))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN As) (S (VP (VBN expected) (, ,) (PP (IN in) (NP (NP (NN fusion)) (PP (IN of) (NP (NP (NP (NN _PROT1_)) (ADVP (RB alone))) (PRN (-LRB- -LRB-) (NP (CD 18) (NN microg/day)) (-RRB- -RRB-))))))))) (VP (VP (VBD augmented) (NP (NN food) (NN intake)) (PRN (-LRB- -LRB-) (NP (NP (CD 191.6) (NN %)) (PP (IN over) (NP (DT the) (JJ initial) (NN control)))) (, ,) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-))) (CC and) (VP (VBD produced) (NP (DT a) (ADJP (CD 25.1) (NN %)) (NN weight) (NN gain)) (PP (IN in) (NP (NP (NN conjunction)) (PP (IN with) (NP (NP (DT a) (JJ 10-fold) (NN increase)) (PP (IN in) (NP (NP (NN serum) (NN _PROT2_) (NNS concentrations)) (PP (IN at) (NP (NP (DT the) (NN end)) (PP (IN of) (NP (DT the) (JJ 7-day) (NN period))))))))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (NP (NN coinfusion)) (PP (IN of) (NP (NP (DT this) (NN regimen)) (PP (IN of) (NP (NN _PROT1_))))) (PP (IN with) (NP (NP (DT the) (ADJP (RB highly) (JJ effective)) (ADJP (ADJP (JJ anorectic)) (CC and) (ADJP (NN body) (VBG reducing))) (NNS effects)) (PP (IN of) (NP (NN CNTF)))))) (PRN (-LRB- -LRB-) (NP (CD 5.0) (NN microg/day)) (-RRB- -RRB-)) (VP (CONJP (RB not) (RB only)) (VP (VBD prevented) (NP (NP (DT the) (JJ CNTF-induced) (NN anorexia)) (CC and) (NP (NN weight) (NN loss)))) (, ,) (CONJP (CC but) (RB also)) (VP (VBN normalized) (NP (NP (NN serum) (NN _PROT2_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT_) (NN gene) (NN expression))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (NP (NN coinfusion)) (PP (IN of) (NP (NP (DT this) (NN regimen)) (PP (IN of) (NP (NN _PROT1_))))) (PP (IN with) (NP (NP (DT the) (ADJP (RB highly) (JJ effective)) (ADJP (ADJP (JJ anorectic)) (CC and) (ADJP (NN body) (VBG reducing))) (NNS effects)) (PP (IN of) (NP (NN CNTF)))))) (PRN (-LRB- -LRB-) (NP (CD 5.0) (NN microg/day)) (-RRB- -RRB-)) (VP (CONJP (RB not) (RB only)) (VP (VBD prevented) (NP (NP (DT the) (JJ CNTF-induced) (NN anorexia)) (CC and) (NP (NN weight) (NN loss)))) (, ,) (CONJP (CC but) (RB also)) (VP (VBN normalized) (NP (NP (NN serum) (NN _PROT_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT2_) (NN gene) (NN expression))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Interestingly)) (, ,) (NP (NP (NN coinfusion)) (PP (IN of) (NP (NP (DT this) (NN regimen)) (PP (IN of) (NP (NN _PROT_))))) (PP (IN with) (NP (NP (DT the) (ADJP (RB highly) (JJ effective)) (ADJP (ADJP (JJ anorectic)) (CC and) (ADJP (NN body) (VBG reducing))) (NNS effects)) (PP (IN of) (NP (NN CNTF)))))) (PRN (-LRB- -LRB-) (NP (CD 5.0) (NN microg/day)) (-RRB- -RRB-)) (VP (CONJP (RB not) (RB only)) (VP (VBD prevented) (NP (NP (DT the) (JJ CNTF-induced) (NN anorexia)) (CC and) (NP (NN weight) (NN loss)))) (, ,) (CONJP (CC but) (RB also)) (VP (VBN normalized) (NP (NP (NN serum) (NN _PROT1_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT2_) (NN gene) (NN expression))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (JJ chronic) (JJ central) (NN infusion)) (VP (TO to) (VP (VB produce) (NP (NP (DT a) (JJ persistent) (NN elevation)) (PP (IN of) (NP (DT the) (NN cytokine)))) (PP (IN at) (NP (NP (JJ pathophysiological) (NNS levels)) (PRN (-LRB- -LRB-) (NP (NP (DT a) (NN situation)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (ADVP (RB normally)) (VP (VBP manifest) (PP (IN during) (NP (NP (NN infection)) (, ,) (NP (NN injury)) (CC and) (NP (NN inflammation))))))))) (-RRB- -RRB-))))))) (VP (VBD produced) (NP (NP (NP (JJ severe) (NN anorexia)) (CC and) (NP (NN weight) (NN loss))) (PP (IN in) (NP (NP (NN conjunction)) (PP (IN with) (NP (NN reduction)))))) (PP (IN in) (NP (CC both) (NP (NN serum) (NN _PROT1_) (NNS concentrations)) (CC and) (NP (JJ hypothalamic) (NN _PROT2_) (NN gene) (NN expression)))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NN ARC) (NN _PROT1_) (NNS neurones)) (VP (VP (VBP are) (VP (VBN stimulated) (PP (IN by) (NP (NP (NN starvation)) (, ,) (ADVP (RB probably)) (VP (VBN mediated) (PP (IN by) (NP (NP (NNS falls)) (PP (IN in) (S (VP (VBG circulating) (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN insulin))) (-LRB- -LRB-) (SBAR (WHNP (WDT which)) (S (VP (DT both) (VP (VBP inhibit) (NP (DT these) (NNS neurones)))))) (-RRB- -RRB-)))))))))))) (, ,) (CC and) (VP (VBP contribute) (PP (TO to) (NP (NP (DT the) (VBN increased) (NN hunger)) (PP (IN in) (NP (NP (DT this)) (CC and) (NP (JJ other) (NNS conditions)))) (PP (IN of) (NP (NN energy) (NN deficit))))))))) |ET|
-1 |BT| (S1 (S (NP (NN ARC) (NN _PROT1_) (NNS neurones)) (ADVP (RB also)) (VP (VBP mediate) (NP (NP (NP (NN hyperphagia)) (CC and) (NP (NN obesity))) (PP (IN in) (NP (NP (DT the) (NP (NP (NN ob/ob)) (CC and) (NP (NN db/db))) (NNS mice)) (CC and) (NP (NN fa/fa) (NN rat)))) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT2_) (NN inhibition)) (VP (VBZ is) (VP (VBN lost) (PP (IN through) (NP (NP (NNS mutations)) (VP (VBG affecting) (NP (NP (NN _PROT_)) (CC or) (NP (PRP$ its) (NN receptor)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN ARC) (NN _PROT1_) (NNS neurones)) (ADVP (RB also)) (VP (VBP mediate) (NP (NP (NP (NN hyperphagia)) (CC and) (NP (NN obesity))) (PP (IN in) (NP (NP (DT the) (NP (NP (NN ob/ob)) (CC and) (NP (NN db/db))) (NNS mice)) (CC and) (NP (NN fa/fa) (NN rat)))) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT_) (NN inhibition)) (VP (VBZ is) (VP (VBN lost) (PP (IN through) (NP (NP (NNS mutations)) (VP (VBG affecting) (NP (NP (NN _PROT2_)) (CC or) (NP (PRP$ its) (NN receptor)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NN ARC) (NN _PROT_) (NNS neurones)) (ADVP (RB also)) (VP (VBP mediate) (NP (NP (NP (NN hyperphagia)) (CC and) (NP (NN obesity))) (PP (IN in) (NP (NP (DT the) (NP (NP (NN ob/ob)) (CC and) (NP (NN db/db))) (NNS mice)) (CC and) (NP (NN fa/fa) (NN rat)))) (, ,) (SBAR (WHPP (IN in) (WHNP (WDT which))) (S (NP (NN _PROT1_) (NN inhibition)) (VP (VBZ is) (VP (VBN lost) (PP (IN through) (NP (NP (NNS mutations)) (VP (VBG affecting) (NP (NP (NN _PROT2_)) (CC or) (NP (PRP$ its) (NN receptor)))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT Both)) (VP (VBP receive) (NP (NP (NN information)) (PP (IN about) (NP (NP (DT the) (JJ nutritional) (NN status)) (CC and) (NP (NP (DT the) (NN level)) (PP (IN of) (NP (NN energy) (NN storage))))))) (PP (IN through) (NP (NP (NP (NP (NN insulin)) (CC and) (NP (NN _PROT1_))) (NN signaling)) (VP (VBN mediated) (PP (IN by) (NP (NP (JJ specific) (NNS receptors)) (ADJP (JJ located) (PP (IN on) (NP (NP (ADJP (ADJP (JJ POMC)) (CC and) (ADJP (JJ _PROT2_))) (NNS neurons)) (ADJP (JJ present) (PP (ADVP (RB predominantly)) (IN in) (NP (NP (DT the) (JJ arcuate) (NN nucleus)) (PRN (-LRB- -LRB-) (NP (NN ARC)) (-RRB- -RRB-))))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (S (SBAR (WHADVP (WRB When)) (S (NP (NN _PROT1_) (NN signaling)) (VP (VBZ is) (ADJP (JJ defective)) (, ,) (PP (IN through) (NP (NP (DT a) (NN defect)) (PP (PP (IN in) (NP (DT either) (NP (NP (DT the) (NN receptor)) (PRN (-LRB- -LRB-) (NP (NP (NN Zucker) (NN fa/fa) (NN rat)) (, ,) (NP (NN cp/cp) (NN rat)) (, ,) (CC and) (NP (NN db/db) (NN mouse))) (-RRB- -RRB-))))) (CC or) (PP (IN in) (NP (DT the) (NN peptide) (PRP itself))) (PRN (-LRB- -LRB-) (NP (NN ob/ob) (NN mouse)) (-RRB- -RRB-)))))))) (, ,) (NP (DT the) (NN _PROT2_) (NN system)) (VP (VBZ is) (VP (VBN upregulated) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN mRNA) (NN overexpression)) (CC and) (NP (VBN increased) (NN peptide) (NN release)))))))))) (, ,) (IN whereas) (S (NP (NP (DT the) (NN content)) (CC and/or) (NP (NP (NN release)) (PP (IN of) (NP (NP (DT some) (JJ inhibitory) (NNS peptides)) (PRN (-LRB- -LRB-) (NP (NN neurotensin)) (, ,) (NP (NN cholecystokinin)) (-RRB- -RRB-)))))) (VP (VBP are) (VP (VBN diminished))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (PRP We)) (VP (VBP propose) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ binds) (PP (TO to) (NP (NP (NP (JJ specific) (NN OT) (NNS receptors)) (PRN (-LRB- -LRB-) (NP (NN OTR)) (-RRB- -RRB-))) (PP (IN on) (NP (DT the) (NN endometrium) (S (VP (TO to) (VP (VB stimulate) (NP (JJ phosphoinositide) (-LRB- -LRB-) (NN PI) (-RRB- -RRB-) (NN hydrolysis))))))))) (, ,) (S (ADVP (RB thereby)) (VP (VBG activating) (NP (NP (NP (NP (DT the) (NN inositol) (NN trisphosphate)) (PRN (-LRB- -LRB-) (NP (NN _PROT2_)) (-RRB- -RRB-))) (NN -diacylglycerol) (-LRB- -LRB-) (NN DAG) (-RRB- -RRB-) (NN second-messenger) (NN system)) (S (VP (TO to) (VP (VB promote) (NP (NN pulsatile) (NN PGF2) (NN alpha) (NN secretion)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (JJ Endometrial) (NN _PROT1_)) (VP (VP (VBD was) (VP (VBN increased) (PP (IN within) (NP (CD 30) (NNS seconds))) (PP (IN after) (NP (NN _PROT2_) (NN treatment))))) (CC and) (VP (VBD preceded) (NP (NP (DT the) (NN increase)) (PP (IN in) (NP (NP (NN PGF2) (NN alpha) (NN release)) (VP (VBN stimulated) (PP (IN by) (NP (NN _PROT_))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Endometrial) (NN _PROT1_)) (VP (VP (VBD was) (VP (VBN increased) (PP (IN within) (NP (CD 30) (NNS seconds))) (PP (IN after) (NP (NN _PROT_) (NN treatment))))) (CC and) (VP (VBD preceded) (NP (NP (DT the) (NN increase)) (PP (IN in) (NP (NP (NN PGF2) (NN alpha) (NN release)) (VP (VBN stimulated) (PP (IN by) (NP (NN _PROT2_))))))))))) |ET|
-1 |BT| (S1 (S (NP (JJ Endometrial) (NN _PROT_)) (VP (VP (VBD was) (VP (VBN increased) (PP (IN within) (NP (CD 30) (NNS seconds))) (PP (IN after) (NP (NN _PROT1_) (NN treatment))))) (CC and) (VP (VBD preceded) (NP (NP (DT the) (NN increase)) (PP (IN in) (NP (NP (NN PGF2) (NN alpha) (NN release)) (VP (VBN stimulated) (PP (IN by) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP support) (NP (DT the) (NN hypothesis) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ stimulates) (NP (NN phospholipase) (NN C)) (S (VP (TO to) (VP (VB hydrolyze) (NP (NN PI))))))))) (, ,) (S (VP (VBG yielding) (NP (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN DAG))) (NNS second-messengers)) (SBAR (WHNP (WDT which)) (S (VP (VBP promote) (NP (NP (JJ endometrial) (NN PGF2) (NN alpha)) (NN release)) (PP (IN during) (NP (NP (NN CL) (NN regression)) (PP (IN in) (NP (NNS pigs)))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT1_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT2_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT_) (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT1_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT_) (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT1_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT2_) (NN _PROT2_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT1_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT2_) (JJ _PROT2_) (NN _PROT_) (NN _PROT_)))))))))))))) (. .))) |ET|
-1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT1_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT_) (JJ _PROT_) (NN _PROT2_) (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (S (NP (DT The) (VBG resulting) (ADJP (RB abnormally) (VBN phosphorylated)) (NN _PROT_)) (VP (VBZ aggregates) (PP (TO to) (NP (ADJP (RB freshly) (VBN synthesized)) (NN _PROT_))) (, ,) (S (VP (VBG transforming) (NP (PRP it)) (PP (IN into) (NP (JJ same))) (: ;) (PP (IN due) (TO to) (NP (NP (DT a) (NN system)) (PP (IN of) (NP (NP (JJ positive) (NN feedback)) (VP (VBN invoked) (PP (IN by) (NP (NP (DT the) (JJ organophosphate-induced) (NN blockage)) (PP (IN of) (NP (DT a) (NN _PROT1_) (JJ _PROT1_) (NN _PROT2_) (NN _PROT2_)))))))))))))) (. .))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (MD may) (ADVP (RB rapidly)) (VP (VB stimulate) (NP (NP (ADJP (NN _PROT2_) (-LRB- _PROT2_) (NN _PROT2_) (-RRB- _PROT2_) (JJ _PROT2_) (PRN (-LRB- -LRB-) (NP (NN IP3)) (-RRB- -RRB-)))) (CC and) (NP (NP (NN diacylglycerol)) (PRN (-LRB- -LRB-) (NP (NN DAG)) (-RRB- -RRB-))) (NP (NN formation))) (, ,) (S (ADJP (JJ consistent) (PP (IN with) (NP (NP (DT the) (NN concept)) (PP (IN of) (NP (NP (JJ rapid) (NN activation)) (PP (IN of) (NP (DT a) (NN second-messenger) (NN system))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NP (NN support)) (PP (IN of) (NP (DT this) (NN hypothesis))))) (, ,) (NP (JJ endometrial) (NN _PROT1_) (NNS levels)) (VP (VBD were) (VP (VBN increased) (PRN (-LRB- -LRB-) (NP (NN P) (NN <) (CD 0.05)) (-RRB- -RRB-)) (PP (IN within) (NP (CD 0.5) (NN min))) (PP (IN after) (NP (NP (NN treatment)) (PP (IN with) (NP (ADJP (CD 0.1) (NN microM)) (NN _PROT2_))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ induces) (NP (JJ endometrial) (NN _PROT2_) (NN production)) (PP (IN in) (NP (NP (DT a) (JJ rapid) (NN manner)) (ADJP (JJ indicative) (PP (IN of) (NP (DT a) (NN second-messenger) (NN system)))))))))))) |ET|
-1 |BT| (S1 (S (S (LST (LS 2) (-RRB- -RRB-)) (NP (NP (NN IGF-1)) (, ,) (NP (NN IGF-2)) (, ,) (CC and) (NP (NN _PROT1_))) (ADVP (RB also)) (VP (VBD induced) (NP (NP (DT a) (NN Ca2+) (NN mobilization)) (PP (IN from) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))) (: :) (S (NP (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NNS inhibitors)) (, ,) (NP (NN neomycin)) (, ,) (CC or) (NP (NN U-73122))) (VP (VP (ADVP (RB partially)) (VBD blocked) (NP (NP (DT the) (JJ intracellular) (NN [Ca2+) (-RRB- -RSB-) (NN i) (NN increase)) (VP (VBN induced) (PP (IN by) (NP (NP (NN IGF-1)) (CC and) (NP (NN _PROT_))))))) (CC and) (VP (ADVP (RB totally)) (VBD inhibited) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN IGF-2))))))))) |ET|
-1 |BT| (S1 (S (S (LST (LS 2) (-RRB- -RRB-)) (NP (NP (NN IGF-1)) (, ,) (NP (NN IGF-2)) (, ,) (CC and) (NP (NN _PROT1_))) (ADVP (RB also)) (VP (VBD induced) (NP (NP (DT a) (NN Ca2+) (NN mobilization)) (PP (IN from) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))) (: :) (S (NP (NP (NP (NP (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NNS inhibitors)) (, ,) (NP (NN neomycin)) (, ,) (CC or) (NP (NN U-73122))) (VP (VP (ADVP (RB partially)) (VBD blocked) (NP (NP (DT the) (JJ intracellular) (NN [Ca2+) (-RRB- -RSB-) (NN i) (NN increase)) (VP (VBN induced) (PP (IN by) (NP (NP (NN IGF-1)) (CC and) (NP (NN _PROT2_))))))) (CC and) (VP (ADVP (RB totally)) (VBD inhibited) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN IGF-2))))))))) |ET|
+1 |BT| (S1 (S (S (LST (LS 2) (-RRB- -RRB-)) (NP (NP (NN IGF-1)) (, ,) (NP (NN IGF-2)) (, ,) (CC and) (NP (NN _PROT_))) (ADVP (RB also)) (VP (VBD induced) (NP (NP (DT a) (NN Ca2+) (NN mobilization)) (PP (IN from) (NP (DT the) (JJ endoplasmic) (NN reticulum)))))) (: :) (S (NP (NP (NP (NP (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))) (NNS inhibitors)) (, ,) (NP (NN neomycin)) (, ,) (CC or) (NP (NN U-73122))) (VP (VP (ADVP (RB partially)) (VBD blocked) (NP (NP (DT the) (JJ intracellular) (NN [Ca2+) (-RRB- -RSB-) (NN i) (NN increase)) (VP (VBN induced) (PP (IN by) (NP (NP (NN IGF-1)) (CC and) (NP (NN _PROT2_))))))) (CC and) (VP (ADVP (RB totally)) (VBD inhibited) (NP (NP (DT the) (NN effect)) (PP (IN of) (NP (NN IGF-2))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN expression)) (CC and) (NP (NN energy) (NN expenditure)))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA) (NNS levels)) (NP (JJR greater) (IN than) (RB twofold)) (PP (IN in) (NP (DT both) (NN ad) (JJ libitum-fed) (CC and) (JJ food-restricted) (NNS rats)))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (NP (NP (DT a) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN energy) (NN expenditure))) (PP (IN in) (NP (JJ nonmutant) (NNS rodents))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT2_)) (VP (VBZ increases) (NP (NN energy) (NN expenditure)))))) (VP (VBZ is) (PP (IN through) (NP (NP (VBN increased) (NN thermogenesis)) (PP (IN in) (NP (NN BAT))))) (, ,) (S (VP (VBG including) (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (NN _PROT_))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (NP (NP (DT a) (JJ _PROT1_) (NN increase)) (PP (IN in) (NP (NN energy) (NN expenditure))) (PP (IN in) (NP (JJ nonmutant) (NNS rodents))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT_)) (VP (VBZ increases) (NP (NN energy) (NN expenditure)))))) (VP (VBZ is) (PP (IN through) (NP (NP (VBN increased) (NN thermogenesis)) (PP (IN in) (NP (NN BAT))))) (, ,) (S (VP (VBG including) (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS data)) (VP (VP (VBP demonstrate) (NP (NP (DT a) (JJ _PROT_) (NN increase)) (PP (IN in) (NP (NN energy) (NN expenditure))) (PP (IN in) (NP (JJ nonmutant) (NNS rodents))))) (CC and) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (CD one) (NN mechanism)) (SBAR (WHPP (IN by) (WHNP (WDT which))) (S (NP (NN _PROT1_)) (VP (VBZ increases) (NP (NN energy) (NN expenditure)))))) (VP (VBZ is) (PP (IN through) (NP (NP (VBN increased) (NN thermogenesis)) (PP (IN in) (NP (NN BAT))))) (, ,) (S (VP (VBG including) (NP (NP (VBN increased) (NN expression)) (PP (IN of) (NP (NN _PROT2_))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN _PROT1_)) (VP (VBZ is) (NP (NP (DT a) (NN mediator)) (PP (IN of) (NP (NP (NNS thermogenesis)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN thyroid) (NN hormone)) (, ,) (NP (JJ beta3-adrenergic) (NNS agonists)) (, ,) (CC and) (NP (NN _PROT2_))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_) (NN mRNA) (NNS levels)) (VP (VBD were) (ADVP (RB also)) (VP (VBN regulated) (PP (IN by) (NP (NP (NN dexamethasone)) (, ,) (NP (NN _PROT2_)) (, ,) (CC and) (NP (NN starvation))))) (, ,) (SBAR (IN albeit) (FRAG (RB differently) (PP (IN in) (NP (NP (NN muscle)) (CC and) (NP (JJ brown) (NN adipose) (NN tissue))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NN PKB)) (, ,) (SBAR (WHNP (WDT which)) (S (VP (VBZ is) (NP (NP (DT an) (JJ important) (JJ early) (NN PI) (NN 3-kinase-dependent) (NN component)) (PP (IN of) (NP (NN _PROT1_) (NN signalling) (NNS pathways))))))) (, ,)) (VP (VBZ is) (ADVP (RB also)) (VP (VBN down-regulated) (PP (IN by) (NP (JJ _PROT2_) (NNS agonists))))))) |ET|
+1 |BT| (S1 (S (NP (NP (JJ Secreted) (NN form)) (PP (IN of) (NP (NN _PROT1_) (NN precursor) (NN protein)))) (VP (VBZ activates) (NP (NP (NP (NN protein) (NN kinase) (NN C)) (CC and) (NP (NN _PROT2_) (NN _PROT2_))) (PP (IN in) (NP (VBN cultured) (JJ embryonic) (NN rat) (JJ neocortical) (NNS cells))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Furthermore)) (, ,) (NP (PRP we)) (VP (VBP demonstrate) (SBAR (IN that) (S (NP (NP (NP (NN tyrosine) (NN phosphorylation)) (PP (IN of) (NP (NN _PROT1_) (NN _PROT1_)))) (CC and) (NP (NP (NN formation)) (PP (IN of) (NP (NN inositol) (NN 1,4,5-trisphosphate))))) (VP (VBD were) (VP (VBN increased) (PP (IN by) (NP (NN _PROT2_)))))))))) |ET|
+1 |BT| (S1 (S (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (JJ possible) (NN involvement)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN _PROT2_)) (CC and) (NP (NN IL-1) (NN action)))) (PP (IN in) (NP (NN Leydig) (NNS cells))))))) (, ,) (NP (DT the) (NN _PROT_) (NN inhibitor) (NN Calphostin) (NN C)) (VP (VBD was) (VP (VBN tested))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (JJ possible) (NN involvement)) (PP (IN of) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (NN _PROT_)) (CC and) (NP (NN IL-1) (NN action)))) (PP (IN in) (NP (NN Leydig) (NNS cells))))))) (, ,) (NP (DT the) (NN _PROT2_) (NN inhibitor) (NN Calphostin) (NN C)) (VP (VBD was) (VP (VBN tested))))) |ET|
-1 |BT| (S1 (S (S (VP (TO To) (VP (VB assess) (NP (NP (DT the) (JJ possible) (NN involvement)) (PP (IN of) (NP (NN _PROT_))) (PP (IN in) (NP (NP (NN _PROT1_)) (CC and) (NP (NN IL-1) (NN action)))) (PP (IN in) (NP (NN Leydig) (NNS cells))))))) (, ,) (NP (DT the) (NN _PROT2_) (NN inhibitor) (NN Calphostin) (NN C)) (VP (VBD was) (VP (VBN tested))))) |ET|
+1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN PMA))) (VP (VBP activate) (NP (NN _PROT2_)))))) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN IL-1)) (ADVP (RB likely)) (VP (VBZ does) (RB not) (VP (VB activate) (NP (NN _PROT_)) (PP (IN in) (NP (NN Leydig) (NNS cells))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (NN _PROT1_)) (CC and) (NP (NN PMA))) (VP (VBP activate) (NP (NN _PROT_)))))) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN IL-1)) (ADVP (RB likely)) (VP (VBZ does) (RB not) (VP (VB activate) (NP (NN _PROT2_)) (PP (IN in) (NP (NN Leydig) (NNS cells))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT These) (NNS results)) (VP (VP (VBP confirm) (SBAR (IN that) (S (NP (NP (NN _PROT_)) (CC and) (NP (NN PMA))) (VP (VBP activate) (NP (NN _PROT1_)))))) (CC and) (VP (VBP indicate) (SBAR (IN that) (S (NP (NN IL-1)) (ADVP (RB likely)) (VP (VBZ does) (RB not) (VP (VB activate) (NP (NN _PROT2_)) (PP (IN in) (NP (NN Leydig) (NNS cells))))))))))) |ET|
+1 |BT| (S1 (S (SBAR (IN If) (S (NP (JJ daily) (NN _PROT1_) (NNS injections)) (VP (VBP are) (VP (VBN repeated) (PP (IN over) (NP (DT a) (JJ 5-day) (NN period))))))) (, ,) (S (S (NP (NN blood) (NN pressure)) (VP (VBZ is) (VP (VBN decreased) (PP (IN by) (NP (CD 10-20) (NN mmHg)))))) (, ,) (S (NP (NP (DT the) (NN withdrawal) (NN latency)) (PP (TO to) (NP (NN heat) (NNS stimuli)))) (VP (VBZ is) (ADJP (JJ prolonged)))) (, ,) (S (NP (NN cortisol) (NNS levels)) (VP (VBP are) (VP (VBN decreased)))) (CC and) (S (NP (NP (NP (NN _PROT2_)) (CC and) (NP (NN cholecystokinin))) (NNS levels)) (VP (VBP are) (VP (VBN increased))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (CC and) (NP (NN _PROT1_))) (VP (VBP modulate) (NP (NP (NN adipose)) (CC and) (NP (NN muscle) (NN _PROT2_) (NN _PROT2_))))) (: :) (NP (NP (JJ divergent) (NNS effects)) (PP (IN between) (NP (NP (NN messenger) (JJ ribonucleic) (NN acid)) (CC and) (NP (NN protein) (NN expression))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (DT this) (NN study))) (, ,) (NP (PRP we)) (VP (VBD examined) (NP (NP (DT the) (NNS effects)) (PP (IN of) (NP (NP (NP (NN fasting)) (PP (IN for) (NP (CD 2) (NNS days)))) (CC and) (NP (NP (JJ exogenous) (NN s.c.) (NN _PROT1_)) (, ,) (NP (NP (ADJP (CD 200) (NN microg)) (DT every) (CD 8) (NN h)) (PP (IN for) (NP (CD 2) (NNS days)))) (, ,)))) (PP (IN on) (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN UCP)) (-RRB- -RRB-))) (NNS subtypes)))))) (PP (IN in) (NP (NP (NP (JJ brown) (NN adipose) (NN tissue)) (PRN (-LRB- -LRB-) (NP (NN BAT)) (-RRB- -RRB-))) (CC and) (NP (JJ gastrocnemius) (NN muscle))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (, ,) (PP (VBN compared) (PP (IN with) (NP (NN vehicle)))) (, ,) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN BAT) (NN _PROT2_)) (CC or) (NP (NN _PROT_) (NN mRNA)) (CC or) (NP (NN protein) (NN expression)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN administered) (PP (TO to) (NP (JJ normal) (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT1_)) (, ,) (PP (VBN compared) (PP (IN with) (NP (NN vehicle)))) (, ,) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN BAT) (NN _PROT_)) (CC or) (NP (NN _PROT2_) (NN mRNA)) (CC or) (NP (NN protein) (NN expression)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN administered) (PP (TO to) (NP (JJ normal) (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NN _PROT_)) (, ,) (PP (VBN compared) (PP (IN with) (NP (NN vehicle)))) (, ,) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (NN BAT) (NN _PROT1_)) (CC or) (NP (NN _PROT2_) (NN mRNA)) (CC or) (NP (NN protein) (NN expression)))) (SBAR (WHADVP (WRB when)) (S (VP (VBN administered) (PP (TO to) (NP (JJ normal) (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NN BAT) (NN _PROT1_) (CC and) (NN _PROT2_) (NN mRNA) (NN expression)) (, ,) (PP (TO to) (NP (NP (NP (CD 31) (NN %)) (CC and) (NP (CD 30) (NN %))) (PP (IN of) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))) (, ,) (ADVP (RB respectively)) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (VP (VBN prevented) (PP (IN by) (NP (NP (NN administration)) (PP (IN of) (NP (NN _PROT_))) (PP (TO to) (NP (JJ fasted) (NNS rats))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NN BAT) (NN _PROT1_) (CC and) (NN _PROT_) (NN mRNA) (NN expression)) (, ,) (PP (TO to) (NP (NP (NP (CD 31) (NN %)) (CC and) (NP (CD 30) (NN %))) (PP (IN of) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))) (, ,) (ADVP (RB respectively)) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (VP (VBN prevented) (PP (IN by) (NP (NP (NN administration)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (JJ fasted) (NNS rats))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD decreased) (NP (NN BAT) (NN _PROT_) (CC and) (NN _PROT1_) (NN mRNA) (NN expression)) (, ,) (PP (TO to) (NP (NP (NP (CD 31) (NN %)) (CC and) (NP (CD 30) (NN %))) (PP (IN of) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS controls))))) (, ,) (ADVP (RB respectively)) (, ,) (NP (NP (NNS effects)) (SBAR (WHNP (WDT which)) (S (VP (VBD were) (VP (VBN prevented) (PP (IN by) (NP (NP (NN administration)) (PP (IN of) (NP (NN _PROT2_))) (PP (TO to) (NP (JJ fasted) (NNS rats))))))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NN Fasting)) (ADVP (RB also)) (VP (ADVP (RB significantly)) (VBD decreased) (NP (NN BAT) (NN _PROT1_) (NN protein) (NN expression)) (, ,) (PP (TO to) (NP (NP (CD 67) (NN %)) (PP (IN of) (NP (NN control))))))) (: ;) (S (ADVP (RB however)) (, ,) (NP (DT that) (NN effect)) (VP (VBD was) (RB not) (VP (VBN prevented) (PP (IN by) (NP (NN _PROT2_) (NN treatment)))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT1_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT2_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT1_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT2_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT1_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT1_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT2_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT1_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
+1 |BT| (S1 (S (S (NP (NP (NN Fasting)) (, ,) (PP (PP (IN with)) (CC or) (PP (IN without) (NP (NN _PROT_) (NN administration)))) (, ,)) (VP (VBD did) (RB not) (VP (VB affect) (NP (NN BAT) (NN _PROT_) (NN mRNA))))) (: ;) (ADVP (RB however)) (, ,) (S (NP (NP (JJ _PROT1_) (NN administration)) (PP (TO to) (NP (ADJP (NN ad) (NN libitum) (JJ fed)) (NNS rats)))) (ADVP (RB significantly)) (VP (VBD increased) (NP (NN BAT) (NN _PROT2_) (NN mRNA)) (, ,) (PP (TO to) (NP (NP (CD 138) (NN %)) (PP (IN of) (NP (NN control))))))))) |ET|
-1 |BT| (S1 (S (NP (NN Fasting)) (ADVP (RB significantly)) (VP (VBD enhanced) (NP (NP (NP (JJ gastrocnemius) (NN muscle) (NN _PROT1_) (NN mRNA)) (PRN (-LRB- -LRB-) (NP (NP (CD 411) (NN %)) (PP (IN of) (NP (NN control)))) (-RRB- -RRB-))) (CC and) (NP (NP (NN protein) (NN expression)) (PRN (-LRB- -LRB-) (NP (NP (CD 168) (NN %)) (PP (IN of) (NP (NN control)))) (-RRB- -RRB-)))) (, ,) (SBAR (IN whereas) (S (NP (NP (JJ _PROT2_) (NN administration)) (PP (TO to) (NP (JJ fasted) (NNS rats)))) (VP (VBD did) (RB not) (VP (VB alter) (NP (NP (DT either)) (PP (IN of) (NP (DT these) (NNS effects))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN summary))) (, ,) (NP (NP (NN _PROT1_) (NN subtype) (NN mRNA)) (CC and) (NP (NN protein))) (VP (VBP are) (VP (VBN regulated) (PP (IN in) (NP (NP (NN tissue-)) (CC and) (NP (NN subtype-specific)) (NP (NN fashion)))) (PP (IN by) (NP (NP (NN _PROT2_)) (CC and) (NP (NN food) (NN restriction)))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (JJ normal) (JJ pancreatic) (NNS islets))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT2_))))) (CC and) (VP (VBZ is) (ADJP (JJ low) (PP (IN in) (NP (NP (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (NN ZDF) (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ normal) (JJ pancreatic) (NNS islets))) (, ,) (NP (NN _PROT1_)) (VP (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT_))))) (CC and) (VP (VBZ is) (ADJP (JJ low) (PP (IN in) (NP (NP (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (NN ZDF) (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (JJ normal) (JJ pancreatic) (NNS islets))) (, ,) (NP (NN _PROT_)) (VP (VP (VBZ is) (VP (VBN upregulated) (PP (IN by) (NP (NN _PROT1_))))) (CC and) (VP (VBZ is) (ADJP (JJ low) (PP (IN in) (NP (NP (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (NN ZDF) (NNS rats)))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT2_) (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT_) (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT1_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT_) (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT2_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT1_) (JJ _PROT2_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT1_) (JJ _PROT_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT2_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (VP (TO To) (VP (VB determine) (SBAR (SBAR (IN whether) (S (NP (NN _PROT_)) (VP (VBZ does) (, ,) (PP (IN in) (NP (NN fact))) (, ,) (VP (VB have) (NP (NN uncoupling) (NN activity)))))) (CC and) (, ,) (SBAR (IN if) (S (ADVP (RB so)) (, ,) (SBAR (IN whether) (S (NP (JJ such) (NN activity)) (VP (MD would) (ADVP (RB favorably)) (VP (VB influence) (NP (NP (DT the) (NNS abnormalities)) (PP (IN in) (NP (NP (JJ _PROT_) (JJ _PROT1_) (NNS islets)) (PP (IN of) (NP (JJ diabetic) (NN ZDF) (NNS rats)))))))))) (, ,) (NP (PRP we)) (VP (VBN transferred) (NP (DT the) (NN _PROT2_) (NN gene)) (PP (TO to) (NP (NP (DT the) (NNS islets)) (PP (IN of) (NP (NP (JJ diabetic) (NN ZDF) (NNS rats)) (CC and) (NP (ADJP (ADJP (JJ lean)) (PRN (-LRB- -LRB-) (NP (NN +/+)) (-RRB- -RRB-))) (NN ZDF) (NN control) (NNS rats)))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP conclude) (SBAR (SBAR (IN that) (S (NP (NN _PROT1_)) (VP (VBZ has) (NP (NN uncoupling) (NN function)) (SBAR (WHADVP (WRB when)) (S (VP (VBN overexpressed) (PP (IN in) (NP (JJ _PROT2_) (NNS islets))))))))) (CC and) (SBAR (IN that) (S (NP (PRP$ its) (NN overexpression)) (VP (VP (VBZ corrects) (NP (NP (DT the) (NN underexpression)) (PP (IN of) (NP (DT the) (NN insulin) (NN gene))))) (CC and) (VP (VBZ ameliorates) (NP (JJ glucose-stimulated) (NN insulin) (NN secretion))) (, ,) (PP (ADVP (RB possibly)) (IN by) (S (VP (VBG increasing) (NP (DT the) (NN ATP) (: :) (NN ADP) (NN ratio)))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT2_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT2_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT1_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT2_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT1_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT2_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT1_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT2_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (JJ second) (NN class)) (PP (IN of) (NP (NP (NN mutant)) (, ,) (NP (NP (NN gse)) (PRN (-LRB- -LRB-) (NP (NN _PROT_) (NN sensitivity)) (-RRB- -RRB-))) (, ,)))) (VP (VBD differed) (ADVP (RB principally)) (PP (IN in) (NP (NN _PROT_) (NN sensitivity))) (, ,) (S (VP (VBG requiring) (NP (NP (ADJP (RB approximately) (RB 100-fold) (JJR higher)) (NN _PROT1_) (-RRB- -RSB-)) (PP (IN for) (NP (CC both) (NP (NN leaf) (NN elongation)) (CC and) (NP (NN _PROT2_) (NN production)))) (PP (IN by) (NP (NN aleurone))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (NNS Neurotransmitters)) (CC and) (NP (NNS hormones))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (NN arginine) (NN vasopressin)) (PRN (-LRB- -LRB-) (NP (NN AVP)) (-RRB- -RRB-))) (CC and) (NP (NN bombesin)))) (, ,)) (VP (VB evoke) (NP (NP (JJ frequency-modulated) (JJ repetitive) (NN Ca2+) (NNS transients)) (PP (IN in) (NP (JJ _PROT1_) (NN HIT-T15) (NNS cells)))) (PP (IN by) (S (VP (VBG binding) (PP (TO to) (NP (NP (NNS receptors)) (VP (VBN linked) (PP (TO to) (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN PLC)) (-RRB- -RRB-))))))))))))) |ET|
-1 |BT| (S1 (S (NP (NP (NP (JJ _PROT1_) (NN signaling)) (PP (IN in) (NP (NN yeast)))) (: :) (NP (NP (NN modulation)) (PP (IN of) (NP (NP (NP (NN protein) (NN phosphatase) (NN 2A)) (, ,) (NP (NN protein) (NN kinase) (NN A)) (, ,) (NP (JJ cAMP-specific) (NN phosphodiesterase)) (, ,) (CC and) (NP (JJ glycosyl-phosphatidylinositol-specific) (NN _PROT2_) (NN _PROT2_))) (NNS activities))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT2_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT1_) (NN _PROT1_) (NN _PROT1_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT1_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT2_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT1_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN addition))) (, ,) (NP (NP (NP (JJ _PROT_) (NN _PROT_) (NN _PROT_)) (PRN (-LRB- -LRB-) (NP (NN GPI-PLC)) (-RRB- -RRB-))) (, ,) (SBAR (WHNP (WDT which)) (S (PP (IN in) (NP (VBN isolated) (NN rat) (NNS adipocytes))) (VP (VBZ is) (VP (VBN activated) (PP (IN by) (NP (NN _PROT_))))))) (, ,)) (VP (VBD was) (VP (VBN stimulated) (PP (TO to) (NP (RB up) (TO to) (RB 5-fold))) (PP (PP (IN by) (NP (NN glucose))) (CC and) (ADVP (RB 10-fold)) (PP (IN by) (NP (NP (NP (NN glucose)) (CC plus) (NP (NN _PROT1_))) (PP (IN in) (NP (NP (CC both) (NP (NN yeast) (NNS spheroplasts)) (CC and) (NP (JJ intact) (NNS cells))) (VP (VBG leading) (PP (TO to) (NP (NP (DT a) (JJ concentration-dependent) (NN leftward) (NN shift)) (PP (IN of) (NP (NP (DT the) (JJ glucose-response) (NN curve)) (PP (IN for) (NP (NP (NN activation)) (PP (IN of) (NP (DT the) (NN _PROT2_))))))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NN _PROT1_)) (VP (VBD was) (ADVP (RBS most) (RB pronouncedly)) (VP (VBN stimulated) (PP (IN by) (NP (JJ authentic) (JJ human) (NN _PROT2_))) (PP (VBN compared) (PP (TO to) (NP (NP (JJ various) (NN insulin) (NNS analogues)) (CC and) (NP (JJ insulin-like) (NN growth) (NN factor) (CD I))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN As) (S (NP (DT the) (NN _PROT1_) (NN reaction)) (VP (VBZ is) (ADJP (NN rate) (VBG limiting))))) (, ,) (NP (NP (DT the) (NN efficiency)) (PP (IN of) (NP (DT the) (JJ two-step) (NN anchor) (NN cleavage)))) (VP (VBD was) (ADVP (RB significantly)) (VP (VBN increased)) (SBAR (WHADVP (WRB when)) (S (NP (NN _PROT2_)) (VP (VBD was) (ADJP (JJ present)) (PP (ADVP (RB together)) (IN with) (NP (NN glucose))) (SBAR (IN as) (S (VP (VBN compared) (PP (TO to) (NP (NN glucose))) (ADVP (RB alone))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (NN _PROT1_) (NNS concentrations)) (ADJP (JJ effective) (PP (IN in) (S (VP (VBG modulating) (NP (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT2_))) (NNS activities))))))) (VP (VBP correlate) (ADVP (RB well)) (PP (IN with) (NP (NP (DT those)) (VP (VBN required) (PP (PP (IN for) (NP (NP (NN half-saturation)) (PP (IN of) (NP (DT the) (JJ specific) (NN binding) (NNS sites))))) (CONJP (RB as) (RB well) (IN as)) (PP (IN for) (NP (NP (NN stimulation)) (PP (IN of) (NP (NP (NN protein) (NN phosphorylation)) (CC and) (NP (NN glycogen) (NN accumulation))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ mammalian) (JJ _PROT1_) (NNS cells)) (CC and) (NP (NN yeast))) (VP (VBP share) (PRN (-LRB- -LRB-) (NP (NP (NN part)) (PP (IN of))) (-RRB- -RRB-)) (NP (NP (DT the) (JJ key) (JJ regulatory) (NN mechanism)) (-LRB- -LRB-) (VP (VBG consisting) (PP (IN of) (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT2_))))) (-RRB- -RRB-) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN transduction)) (PP (IN of) (NP (NP (DT the) (NN _PROT_) (NN signal)) (PP (IN from) (NP (DT the) (JJ respective) (NN receptor) (NNS systems))) (PP (TO to) (NP (NP (NN glycogen) (NN synthase)) (CC and) (NP (NN phosphorylase)))))))))))))))) |ET|
-1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ mammalian) (JJ _PROT1_) (NNS cells)) (CC and) (NP (NN yeast))) (VP (VBP share) (PRN (-LRB- -LRB-) (NP (NP (NN part)) (PP (IN of))) (-RRB- -RRB-)) (NP (NP (DT the) (JJ key) (JJ regulatory) (NN mechanism)) (-LRB- -LRB-) (VP (VBG consisting) (PP (IN of) (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT_))))) (-RRB- -RRB-) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN transduction)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN signal)) (PP (IN from) (NP (DT the) (JJ respective) (NN receptor) (NNS systems))) (PP (TO to) (NP (NP (NN glycogen) (NN synthase)) (CC and) (NP (NN phosphorylase)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (DT The) (NNS data)) (VP (VBP suggest) (SBAR (IN that) (S (NP (NP (JJ mammalian) (JJ _PROT_) (NNS cells)) (CC and) (NP (NN yeast))) (VP (VBP share) (PRN (-LRB- -LRB-) (NP (NP (NN part)) (PP (IN of))) (-RRB- -RRB-)) (NP (NP (DT the) (JJ key) (JJ regulatory) (NN mechanism)) (-LRB- -LRB-) (VP (VBG consisting) (PP (IN of) (NP (NP (NN PP2A)) (, ,) (NP (NN PKA)) (, ,) (NP (NN cAMP-PDE)) (, ,) (CC and) (NP (NN _PROT1_))))) (-RRB- -RRB-) (VP (VBN involved) (PP (IN in) (NP (NP (DT the) (NN transduction)) (PP (IN of) (NP (NP (DT the) (NN _PROT2_) (NN signal)) (PP (IN from) (NP (DT the) (JJ respective) (NN receptor) (NNS systems))) (PP (TO to) (NP (NP (NN glycogen) (NN synthase)) (CC and) (NP (NN phosphorylase)))))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT The) (ADJP (NN glycosyl-phosphatidylinositol) (VBN anchored)) (NN protein)) (, ,) (NP (NP (NN membrane) (NN dipeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.13.19)) (-RRB- -RRB-)))) (VP (VBZ is) (VP (VBN released) (PP (IN from) (NP (NP (DT the) (NN surface)) (PP (IN of) (NP (NN 3T3-L1) (NNS adipocytes))))) (PP (IN in) (NN response) (TO to) (NP (NN _PROT1_) (NN treatment))) (PP (IN through) (NP (NP (DT the) (NN action)) (PP (IN of) (NP (DT a) (NN _PROT2_) (NN _PROT2_))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN X-Pro) (NN aminopeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.11.9)) (-RRB- -RRB-))) (VP (VBZ is) (ADJP (JJ GPI-anchored)) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes))) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN digestion)) (PP (IN with) (NP (JJ bacterial) (JJ phosphatidylinositol-specific) (NN _PROT1_) (NN _PROT1_))))))))))) (, ,) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN released) (PP (IN upon) (NP (NP (NN _PROT2_) (NN treatment)) (PP (IN of) (NP (DT the) (NNS cells)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (RB only) (DT a) (NN subset)) (PP (IN of) (NP (DT the) (JJ GPI-anchored) (NNS proteins)))) (VP (VBP are) (ADJP (JJ susceptible) (PP (TO to) (NP (JJ _PROT_) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN X-Pro) (NN aminopeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.11.9)) (-RRB- -RRB-))) (VP (VBZ is) (ADJP (JJ GPI-anchored)) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes))) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN digestion)) (PP (IN with) (NP (JJ bacterial) (JJ phosphatidylinositol-specific) (NN _PROT1_) (NN _PROT1_))))))))))) (, ,) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN released) (PP (IN upon) (NP (NP (NN _PROT_) (NN treatment)) (PP (IN of) (NP (DT the) (NNS cells)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (RB only) (DT a) (NN subset)) (PP (IN of) (NP (DT the) (JJ GPI-anchored) (NNS proteins)))) (VP (VBP are) (ADJP (JJ susceptible) (PP (TO to) (NP (JJ _PROT2_) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (SBAR (IN Although) (S (NP (NP (NN X-Pro) (NN aminopeptidase)) (PRN (-LRB- -LRB-) (NP (NN EC) (CD 3.4.11.9)) (-RRB- -RRB-))) (VP (VBZ is) (ADJP (JJ GPI-anchored)) (PP (IN in) (NP (NN 3T3-L1) (NNS adipocytes))) (SBAR (IN as) (S (VP (VBN shown) (PP (IN by) (NP (NP (NN digestion)) (PP (IN with) (NP (JJ bacterial) (JJ phosphatidylinositol-specific) (NN _PROT_) (NN _PROT_))))))))))) (, ,) (S (NP (PRP it)) (VP (VBD was) (RB not) (VP (VBN released) (PP (IN upon) (NP (NP (NN _PROT1_) (NN treatment)) (PP (IN of) (NP (DT the) (NNS cells)))))) (, ,) (S (VP (VBG indicating) (SBAR (IN that) (S (NP (NP (RB only) (DT a) (NN subset)) (PP (IN of) (NP (DT the) (JJ GPI-anchored) (NNS proteins)))) (VP (VBP are) (ADJP (JJ susceptible) (PP (TO to) (NP (JJ _PROT2_) (NN release))))))))))))) |ET|
-1 |BT| (S1 (S (NP (PRP We)) (VP (VBP have) (VP (VBN established) (SBAR (IN that) (S (NP (NP (DT the) (NN recovery)) (PP (IN of) (NP (VBN secreted) (NN _PROT1_)))) (VP (VBZ is) (VP (VBN increased) (PP (IN by) (NP (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NNS agonists)) (NP (NP (NN PDBu)) (CC and) (NP (NN PMA))))) (PP (IN in) (NP (DT a) (ADJP (ADJP (NN time-)) (CC and) (ADJP (JJ dose-dependent))) (NN manner))) (PP (IN in) (NP (DT both) (NN cell) (NNS lines))))))))))) |ET|
-1 |BT| (S1 (S (PP (IN In) (NP (NN contrast))) (, ,) (NP (NP (NN secretion)) (PP (IN of) (NP (NN _PROT1_)))) (VP (VBZ remains) (VP (VBN unaffected) (PP (PP (IN by) (NP (DT the) (JJ inactive) (NN PDBu) (NN analog) (NN alphaPDD))) (CC and) (PP (IN by) (NP (NP (DT the) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (NNS effectors)) (NP (NP (NN dibutyryl) (NN cAMP)) (CC and) (NP (NN forskolin)))))))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ normal) (NN processing)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))) (VP (VBZ is) (VP (VBN up-regulated) (PP (IN by) (NP (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)) (CONJP (CC but) (RB not)) (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)))) (PP (IN in) (NP (NP (JJ human) (NNS cells)) (CC and) (NP (JJ murine) (NNS neurons))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ normal) (NN processing)) (PP (IN of) (NP (NP (NN _PROT1_)) (PRN (-LRB- _PROT1_) (NP (NN _PROT1_)) (-RRB- _PROT1_))))) (VP (VBZ is) (VP (VBN up-regulated) (PP (IN by) (NP (NP (NN _PROT_) (NN _PROT_) (NN _PROT_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NP (JJ human) (NNS cells)) (CC and) (NP (JJ murine) (NNS neurons))))))))))) |ET|
-1 |BT| (S1 (S (ADVP (RB Overall)) (, ,) (NP (PRP$ our) (NNS data)) (VP (VBP indicate) (SBAR (IN that) (S (NP (NP (DT the) (JJ normal) (NN processing)) (PP (IN of) (NP (NP (NN _PROT_)) (PRN (-LRB- _PROT_) (NP (NN _PROT_)) (-RRB- _PROT_))))) (VP (VBZ is) (VP (VBN up-regulated) (PP (IN by) (NP (NP (NN _PROT1_) (NN _PROT1_) (NN _PROT1_)) (CONJP (CC but) (RB not)) (NP (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (PP (IN in) (NP (NP (JJ human) (NNS cells)) (CC and) (NP (JJ murine) (NNS neurons))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (DT A) (JJ caveolin-1-dependent) (NN coupling)) (PP (IN of) (NP (NN _PROT1_))) (PP (TO to) (NP (DT the) (NN _PROT2_) (NN _PROT2_) (NN _PROT2_)))) (VP (VBD was) (VP (VBN observed))))) |ET|
+1 |BT| (S1 (S (ADVP (RB Recently)) (NP (JJ several) (JJ significant) (NNS advances)) (VP (VBP have) (VP (VBN been) (VP (VBN made) (PP (IN in) (NP (DT this) (NN area))) (, ,) (PP (VBG including) (NP (NP (NP (DT the) (NN identification)) (PP (IN of) (NP (NP (DT the) (JJ appetite) (NN regulating) (NN hormone)) (, ,) (NP (NN _PROT1_)) (, ,)))) (CC and) (NP (NP (DT a) (JJ detailed) (NN understanding)) (PP (IN of) (NP (NP (PRP$ its) (NNS targets)) (PP (IN in) (NP (NP (DT the) (JJ central) (JJ nervous) (NN system)) (PRN (-LRB- -LRB-) (NP (NN CNS)) (-RRB- -RRB-)))) (, ,) (PP (JJ such) (IN as) (NP (NP (NP (NN _PROT2_) (NN _PROT2_)) (PRN (-LRB- -LRB-) (NP (NN NPY)) (-RRB- -RRB-))) (CC and) (NP (DT the) (NN melanocortin-4) (NN receptor)))))))))))))) |ET|
+1 |BT| (S1 (S (NP (NP (NP (NN Activity)) (CC and) (NP (NN expression))) (PP (IN of) (NP (DT the) (CD three) (NN _PROT1_) (NNS 's)))) (VP (VBP are) (VP (VBN stimulated) (PP (IN by) (NP (NP (NP (JJ several) (NNS neuromediators)) (CC and) (NP (NNS hormones))) (PP (JJ such) (IN as) (NP (NP (NN noradrenaline)) (, ,) (NP (NN tri-iodothyronine)) (CC and) (NP (NN _PROT2_)))))))))) |ET|
