Dozent: Stefan Hougardy
Termine
Beginn der Vorlesung: 22.10.2003| VL | Mittwoch | 09:00 - 11:00 | (RUD 26, 1.303) |
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| Freitag | 11:00 - 13:00 | (RUD 26, 1.303) |
Zuordnung
- Hauptstudium, Halbkurs
- Theoretische Informatik
Voraussetzungen
- Grundstudium
Inhalte und Lernziele
Die Vorlesung beschäftigt sich mit algorithmischen Fragestellungen in der Bioinformatik, insbesondere solchen, die für das Drug-Design von Relevanz sind. Behandelte Themen werden u.a. sein: Clusteralgorithmen, Erzeugung zufälliger DNA, 3D-Struktur von Molekülen, Zufallsmodelle für biologische Netzwerke.
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| atomare Ansicht eines Proteins | strukturelle Ansicht eines Proteins | 3D-Struktur von Aspirin |
Empfohlene Literatur
- , Bioinformatics -- From Genomes to Drugs, Volume 1: Basic Technologies, Wiley-VCH 2002.
- , Bioinformatics -- From Genomes to Drugs, Volume 2: Applications, Wiley-VCH 2002.
- MolecularModelling, Vortrag von Florian Kamm.
Links
ATC-Codes
3D-Strukturen
RNA Sekundärstruktur
- Vienna RNA Secondary Structure Prediction
- Beispiele
- beliebig:AUGCUGAUCGAUAUAGCUAGAUCGUAGAUCGAUAGCUAGCUAGAUGACUGAGCUAGCUAGAUCGAUAUAUAGCUAGCUCGCUAGCUAGCUAGCUAGCUAGCUAGCUAGCUAGCUACGACUGACUACGAUCGACUACGACUAGCAUCAGCAUCGACUACGACUACGAUCAGCAUCGACUACGACUACGAUCGACU
- random:AACAUGUAUUAUACAUCUCUGCGUAUUACUUACUCCUCCAAAGAGACGCGGAGGCGCAGUACUCGGCGUAGCCGAACCGCGUAGUCAUGCAAUAGUUAGGGAAAACCUGUGUUCCAAAAAGAGUUCUUGGCUUUCGGGUGGCGAUUAAGGACCGCUGGUGAACUACUAACGGAGAUCGUUCUUUACCACUACUACGAGCGUUAAGCGGGAGAACGUCAAAAUUUAUGUGCGUUGCGUGGCUUGCUAGCCCACUUGUCAAACUCCCUUCAAAGUAAGUUGUAUAGUCGGCAUCGAAAUUAA
- randomlang:UUUGCGCAAUCACCCGGGUUAAUGUAAGUGCCGCCCAUAACAACCCAAGCCGACGUAGUAUGCGUUCGCUUUAAAGUGUAAAGCGAUCUGCAGCUCUGUAUGCAACGGCCACAGGGACAGACGAUACCCUCAUGAUCUUGAAAAUCAAGCAAAAAGGGGUUCUUCGUGCCUUUUUUGCCGUUGAAAUGAUCCAUCACUGAUAAGCUACUCUUGAGUACAAUAUAGUCGGCCACCGUGGGUACACUGCCAUGUAGCUGGUUGCCACACGCUGCUUUCGAAUCACAUGAAGAGUUAAUCAACCCACGGGUAAUCCCUUGAUAACUCGACAGGUUUCGCACUUUUGCCAUAGGCGAGUACUCAAGGGGACUUCGACCGGCUGAAGUCGGCAAGGAGCCUAAGGUCCGGAUCGUUUGGGUUUGAGUGAGAGCGUUUGUCUCGCUGAAGGAUCUAGAUAUAGGUACGAGCUUCUGGUCUAGGGAGCCGAGACCCAUUCUGGUACGCAAGUGUAGUAUACCAAAGCGGGGACUAGGCACACAAGGGUACAACGCGUUAACGCUCUUAGUACCCCAUGUCAUAUCAAUUCGUGUCGCCAGACUCUUCGGCUUUAGUUUCAUCGACACUCUCGUCUCGGACAAGGGCAUAGUAGGGUUCAGCCUUUCUCUAUCUGGGUGCAGAACGUAAAGGCCUCCAGCUAGAGAUUGAUUAUGAGCUCGCUAGAAAAGAAAUAUAAAGUCUGUAUGCAGUCCCCUUCCUAAUCUGCAGCGGGAUGCUGCAUCUCAGCGACCGAAGCUGAGGGCAGCUCAAGCCGAAAGGCGACGCCGUUUUACUGAAGAGCCGACGCGUUCCCUCAGCUUAGGUGUCCGCGGUACCAGCCCAGCGUGAUUCUUCCGUGACGUCGUCGCCGCGCUAGGUUCGACAUAGAAGGUAAUUUUUGUCUCGGCUCGGUUCUUCUUAUAUAGAAGAUAUCAUUAGGGAUGCUUACCAAGUACAUGGAUAGUAAUCUAGACCCUGUUUUUGAAUGUCAGCCACCAGUGGAUAUGACCGGGUAGCCAUUAACGGACCCUUCGUGGGUCCAGGUAAGACGGCAUGUGAUUGCGAACCGAAUGGGGCGUACGUCAAAUUCGCACUCAUUAUUGAAGUUAAACAGACAGUGUACCGCCGCCGGGUUCCAAUUGUGUAACUAAGAUCUAUCCUGAAUCGACAACUGCCCUUCAGUCAUGCGCGUUAUGGAAUGCGUGAGACUGAUACGACGAUGGAUACUAGCGUACCCGAGAUAUAGCGUUACCUCCAUUACCUGCCGUAGUAGGUCCCAUUCGGCGGACAGGGCAUCCAUACUUACAGUGGCCCCGUUCGGUUAUAUGCUCGUGCGUUAGCUGGUCUUACUAUACGCGGCCGCUCCUAAAAGUUAGCACCUACUGACGCAUCCGAAACGUUCUGGAGGAGUAUGUUUCGCAUAAUUCUAUGGCUUUAGCACAGUGUCACUGUAGUCUCUGAUCCGCGCUCCGUCGGUAAGGACGCUGUUAAAUGAACCGUGGACAUAACCUAAUAGAAAUCGUGGUGUUAAGGAGGGGCCUUUUUAGCAACAAACUAUGAGACAUUCGGCAAUGAUUCUGGUAGUUAGACCGCCGAUAACAUGGGGGAGUAGGAUAAGCUACAGAGUUCCGUGGAAGACAUCUCAAUCAGAGGAUCGUGAGGGAGAGCGGAGAGUAACCUUCCGGAGGACCCCGCGGAGGUCACCACGCGAGGCCUGUCAAUCUACAGGGGACAACUGGCGUCCCUGGCUUUGGCCCCUGCCUGAUACUCUGUAACUAUAUAAACUACGGGCGUUCCAAUCGUUUACACGAGGUAAGCUCACGAGUGGAUGGACUGCUUGGGGGGGCAUUGAAGUCCCAAGUAUUAAAUGCCCGUUUACCUCCUCUCGCCUGAGUAGUGCUUUUACCGUCCGGGCAGGCCGCAGGAA
- pattern:UGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCAUGCA
- monoton:AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
- unbalanciert:AAGGGUUCCGCGUCCUUUUCGCGGCCGCUCCUCCUGGCUAACCCGAAAGCGCGCCCCUGCCCCUGCUUCCCAGGGGCGCCAUCGAUCACCCGCCGCUGCUGCCAUGGGGCCACAUGACGUGCAUAACCGCCCCAGCUCCCCGCCCGCACGCUCACCUGACUGGCGAGGCCGGCCCCCCGUCCGGCUUCUGGGUCCCUCGUCCCACGCUCCCCUCGUCCCCAUUACCGCCGCCCCCACCGGGUCCCCGCCCGCCCCAUGCAAGCGACCUGUGGAGGGGCUACCGCCACACCUCCCCUUUUC
- unbalanziertePaare:AGCGGAUAGGCGGGGGGCCGGGGCCGCCGGUCCCGCCGCCGUCGCGGGGCGACGGGCGAAGGCGCGGCCCCGGGCUCGCCGGCGCCCACGGGUGGCGCCCGGCCGGCGGAAGAGCGCCCCGCGCCCGGGAGCGCAUGCGGGUCCGCGGGGCGGGCCGUGACGCGCCCCCCAGGCUGGCGCGGGCCGCGCGCGGCGACACCGCGUGGCUGGCGUGGUGGCGGACGGGCGCGCGGCCCCCGCGGGCGCGGCUUCCCCGCCGGGCCCGGGGCGGCGCCCGUCCAUCCCCGGGGUCCGGGGCCC
- H.sapiens_L1h_gene_for_ribosomal_protein:gtatcctttgtttcactacctaagactggtcatctctgatggaatttagcggcctgggtc61tggtttattgatgataatacggtgtaaaaatattacttttttttgtcttgaagagaaggg121gcttcatttatatggggttattttgcttgcaatgatgtcgtaatttgcgtcttactctgt181tctcagcgacagttgcctgctgtcagtaagctggtacagaaggttgacgaaaattcttac241tgagcaagaaataaccttgttgtaattactaaaatttgagaaatgtgattcttgactgga301aaaatag
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